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Youssfi, Younès. "Exploring Risk Factors and Prediction Models for Sudden Cardiac Death with Machine Learning". Electronic Thesis or Diss., Institut polytechnique de Paris, 2023. http://www.theses.fr/2023IPPAG006.
Pełny tekst źródłaSudden cardiac death (SCD) is defined as a sudden natural death presumed to be of cardiac cause, heralded by abrupt loss of consciousness in the presence of witness, or in the absence of witness occurring within an hour after the onset of symptoms. Despite progress in clinical profiling and interventions, it remains a major public health problem, accounting for 10 to 20% of deaths in industrialised countries, with survival after SCD below 10%. The annual incidence is estimated 350,000 in Europe, and 300,000 in the United States. Efficient treatments for SCD management are available. One of the most effective options is the use of implantable cardioverter defibrillators (ICD). However, identifying the best candidates for ICD implantation remains a difficult challenge, with disappointing results so far. This thesis aims to address this problem, and to provide a better understanding of SCD in the general population, using statistical modeling. We analyze data from the Paris Sudden Death Expertise Center and the French National Healthcare System Database to develop three main works:- The first part of the thesis aims to identify new subgroups of SCD to improve current stratification guidelines, which are mainly based on cardiovascular variables. To this end, we use natural language processing methods and clustering analysis to build a meaningful representation of medical history of patients.- The second part aims to build a prediction model of SCD in order to propose a personalized and explainable risk score for each patient, and accurately identify very-high risk subjects in the general population. To this end, we train a supervised classification algorithm, combined with the SHapley Additive exPlanation method, to analyze all medical events that occurred up to 5 years prior to the event.- The last part of the thesis aims to identify the most relevant information to select in large medical history of patients. We propose a bi-level variable selection algorithm for generalized linear models, in order to identify both individual and group effects from predictors. Our algorithm is based on a Bayesian approach and uses a Sequential Monte Carlo method to estimate the posterior distribution of variables inclusion
Clough, Matthew. "Defect screening of pipelines using circumferential guided waves". Thesis, University of Warwick, 2016. http://wrap.warwick.ac.uk/92360/.
Pełny tekst źródłaMontanari, Silvia. "Sinergia di processi chimico-fisici per la riqualificazione di acque contaminate da composti organici". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9260/.
Pełny tekst źródłaEspona, Fiedler Margarita. "Estudio de los mecanismos moleculares involucrados en las propiedades anticancerosas y antimetastásicas de las prodigininas. Identificación de mTOR como diana molecular en células de melanoma". Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/92560.
Pełny tekst źródłaMECHANISMS OF ACTION INVOLVED IN THE ANTICANCER AND ANTIMETASTATIC PROPERTIES OF PRODIGININES. Identification of mTOR as a molecular target in melanoma cells. Because of high chemotherapeutic resistance of metastatic melanoma are necessary new strategies with improved drugs, more effectives with lower toxicity. Anticancer activity of prodiginines has been described in vitro and in vivo in different cancer cell models, including melanoma. Prodiginines are tripyrrolic molecules from bacterial metabolism under pre-clinical and clinical evaluation. In this study we have focused our efforts on identified the molecular mechanisms of prodiginines involved in their cytotoxic effects. In melanoma cells, we have observed the activation of both cell death mechanisms: apoptosis and autophagy after prodigiosin treatment. Our results demonstrate that prodigiosin is a BH3-mimetic drug, as it was previously described for obatoclax (GX15-070). Obatoclax is a synthetic prodiginine derivative actually in clinical trials in phase III. Moreover, we have identified mTOR as a new molecular target of prodigiosin and obatoclax. PI3K/AKT/mTOR pathway is involved in cell survival, proliferation and migration. Different cross-talks and feedback loops regulate this pathway and, also, are involved in different compensatory mechanisms that confer chemoresistance to melanoma cells. Dual inhibition of mTORC1 and mTORC2 mediated by both prodiginines disrupted the negative feedback loop S6K/IRS-1. The interaction of both prodiginines in the active site of mTOR was monitorized by Surface Plasmon Resonance (SPR) assays. Nanomolar kinetic and affinity parameters indicated high affinity, stability and specificity of these interactions. Nevertheless, results showed that both prodiginines are not ATP-mimetic drugs. In silico models showed the detailed atomic view of the complexes indicating the critical residues involved in these interactions. Moreover, structure-activity relationship (SAR) studies corroborated the importance of pyrrole amino groups in the cytotoxic prodiginines activity mediated by mTOR inhibition. Finally, we observed that mTOR inhibition by prodiginines promotes actin filaments desorganization, decrease of focal adhesions and inhibition of cell migration. Our results suggest that prodiginines might inhibit integrin signalling through ILK/rictor complex. Alltogether, these results contribute to further understanding the molecular mechanisms of prodiginines and, also, their chemotherapeutical potential. Moreover, we provide new data about their structural properties that will allow the development of more-effective anticancer molecules.
Farhat, Ian Anderson Guimarães Konopczyk Maluf [UNESP]. "Modificação de superfícies de zircônia empregada a restaurações sem metais". Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/92060.
Pełny tekst źródłaA Odontologia ainda não apresenta recomendação específica quanto ao tratamento adequado da superfície de cerâmicas a base de zircônia, a fim de melhorar sua adesão à dentina. Esta pesquisa estudou as propriedades Físico- Químicas dos diferentes tratamentos de superfície aplicados a corpos de prova confeccionados em zircônia estabilizados por ítria (Lava Frame Y-TZP, 3M ESPE), utilizados em restaurações sem metais. Foram aplicados diferentes condicionamentos ácidos (Ácido Fluorídrico entre outros ácidos) em sua superfície e o efeito da irradiação por feixe de laser Yb:YAG. Para a avaliação da união cerâmica/dentina foram realizados ensaios mecânicos de cisalhamento por extrusão, empregando-se corpos de prova cimentados com cimento resinoso (Panavia F, Kuraray Medical Inc., Okayama, Japan), em discos de dentina bovina. Os corpos de prova foram selecionados aleatoriamente para análise de superfície empregando-se microscopia eletrônica de varredura (MEV) antes de qualquer modificação superficial, após as modificações de superfície e após os ensaios mecânicos, e Difração de raios X, a fim de se observar a fase da zircônia existente em cada amostra
Dentistry does not present specific recommendation regarding the appropriate treatment of surface of the zirconia based ceramics in order to improve their adhesion to dentin. This research studied the Physical-Chemical properties of various surface treatments applied to specimens made of yttria-stabilized zirconia (Lava Frame Y-TZP, 3M ESPE), used in metal-free restorations. Will apply different conditioning acids (Hydrofluoric Acid and other acids) on the surface and the effect of irradiation by the laser Yb:YAG beam. To evaluate the ceramic / dentin union were performed mechanical tests shear extrusion, using specimens cemented with resin cement (Panavia F, Kuraray Medical Inc., Okayama, Japan) in bovine dentin discs. Specimens are randomly selected for surface analysis employing electron microscopy (SEM) before any surface modification, after the surface modifications and after the mechanical tests, and X-ray diffraction, to identify the phase of zirconia in each sample
Damatto, Ricardo Luiz [UNESP]. "Caracterização morfológica, bioquímica e molecular do músculo esquelético sóleo de ratos espontaneamente hipertensos com insuficiência cardíaca". Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/92160.
Pełny tekst źródłaCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
A insuficiência cardíaca (IC) caracteriza-se por redução da tolerância aos exercícios com a ocorrência precoce de fadiga e dispnéia. Além de disfunção cardíaca e pulmonar, anormalidades intrínsicas da musculatura esquelética têm sido responsabilizadas pela intolerância aos esforços físicos. Em músculos periféricos e respiratórios, frequentemente são observadas atrofia e modificação nas isoformas das cadeias pesadas de miosina (MyHC) na IC. Os mecanismos e vias intracelulares de sinalização responsáveis por essas alterações ainda não estão completamente definidos. Em modelos experimentais de IC induzida por estenose aórtica ou infarto do miocárdio, verificamos que alterações na expressão dos fatores de regulação miogênica e da via miostatina/folistatina podem modular o trofismo muscular e a composição das MyHCs. Um dos modelos experimentais muito utilizados para o estudo da IC é o rato espontaneamente hipertenso (SHR). Estes animais apresentam, precocemente, hipertensão arterial e hipertrofia ventricular esquerda e, em idade avançada, desenvolvem IC. Não identificamos estudos que avaliaram o comprometimento da musculatura esquelética de SHR com IC. O objetivo deste estudo foi caracterizar as alterações da musculatura esquelética de SHR com IC por meio de avaliação da morfologia, das isoformas das cadeias pesadas de miosina e da expressão gênica e protéica dos fatores de regulação miogênica e da via miostatina/folistatina. A partir de 18 meses de idade, ratos espontaneamente hipertensos foram avaliados duas vezes por semana à procura de evidências clínicas de IC como taquipnéia, perda de peso e apatia. Após a detecção de IC, os animais foram submetidos a ecocardiograma transtorácico para a confirmação de disfunção ventricular e eutanasiados. No momento da eutanásia, foram...
Heart failure (HF) is characterized by limited exercise tolerance due to increased muscle fatigue and impaired endurance. Besides cardiac and pulmonary dysfunction, intrinsic skeletal muscle abnormalities have been shown to be involved on reduced exercise tolerance. muscle mass loss and a shift in myosin heavy chain (MyHC) isoforms have been frequently observed in peripheral and respiratory skeletal muscles during HF. The pathophysiological mechanisms and intracellular pathways responsible for muscle changes are not completely defined. We observed that myogenic regulatory factors expression and myostation/follistatin pathway modulate muscle trophism and MyHC isoforms in experimental aortic stenosis- and myocardial infarction-induced HF. The spontaneously hypertensive rat (SHR) is often used in HF studies. These rats develop systemic arterial hypertension and left ventricular hypertrophy early and HF at 18-22 month-age approximately. To the best of our knowledgement, there is not study on skeletal muscle evaluation in SHR with HF. The aim of this study was to characterize skeletal myopathy of SHR with HF by evaluating soleus muscle morphology, MyHC isoforms, and gene and protein expression of myogenic regulatory factors, myostatin, and follistatin. Eighteen month-old spontaneously hypertensive rats were evaluated twice a week to identify HF clinical features such as taquipnea, weight loss, and apathy. After detecting HF, rats were subjected to transthoracic echocardiogram. During euthanasia, we evaluated pathological evidences of HF such as pleuropericardial effusion, ascites, left atrial thrombi, right ventricular hypertrophy, and lung congestion. Agematched Wistar-Kyoto rats used as controls. Soleus morphology was analyzed in haematoxyin and eosin and picro-sirius red stained sections, and MyHC isoforms were evaluated by protein... (Complete abstract click electronic access below)
Ikefuti, Michelle Venâncio [UNESP]. "Concepções de licenciandos sobre violência sexual e políticas educacionais". Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/92260.
Pełny tekst źródłaCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
O presente trabalho vinculado à Linha de Pesquisa Processos Formativos, Diferença e Valores, no Programa de Pós-Graduação em Educação da Universidade Estadual Paulista, campus de Presidente Prudente-SP, teve como objetivos identificar o nível de conhecimento que os futuros professores dos cursos de licenciaturas de três campus da Unesp têm acerca da violência sexual e temas afins, bem como elucidar se esta temática é trabalhada dentro dessas faculdades. Dentre as violências domésticas que podem ser cometidas contra crianças e adolescentes, a violência sexual é uma das modalidades mais difíceis de serem detectadas, sendo que a maioria das situações ocorre dentro da casa da vítima, e é cometida muitas vezes por alguém que ela conhece e confia. Diante disso, e sabendo que a escola ocupa um tempo importante na vida das crianças e adolescentes, destacamos que o professor tem um papel fundamental na prevenção, revelação e intervenção de casos de abuso e exploração sexual. A pesquisa foi desenvolvida nos campus da UNESP (Araraquara, Presidente Prudente e São José do Rio Preto), sendo que aplicamos um questionário que contou com a participação dos alunos dos últimos anos de oito cursos de licenciatura (Biologia, Educação Física, Física, Geografia, Letras, Matemática, Pedagogia e Química) totalizando 441 participantes. Foram utilizados os softwares SPSS, versão 12.0 e o EVOC (Ensemble de Programmes Permettant I’ Analyse dês Évocations), versão 2000, para tabular as questões fechadas e as evocações de palavras respectivamente. As análises dos resultados foram feitas utilizando os documentos governamentais que regem a área de Educação no país, além dos Planos Estadual e Nacional de enfrentamento à violência sexual. Como resultados, percebemos que nas três unidades os alunos não se sentem preparados para lidar com casos de violência sexual...
This study is connected with the research line “Formative processes, differences and values” at the Graduate Studies in Education at UNESP, Campus of Presidente Prudente. The research aimed to identify the level of knowledge that future teachers of undergraduate courses of three Campus at Unesp have about the sexual violence and related issues, and to clarify whether this theme was discussed during their course in these Universities. Amongst the domestic violence that can be committed against children, sexual violence is one of the methods more difficult to detect, and most situations occurs inside the victim's home, and it is often committed by someone he knows and trusts. Given this, and knowing that the school occupies an important moment in the lives of children and adolescents, we emphasize that the teacher has a key role in prevention, intervention and revelation of abuse and sexual exploitation. It was developed at the Campus of Araraquara, Presidente Prudente and São José do Rio Preto, and it was applied a questionnaire with students attending the last year of 8 undergraduate courses (Biology, Physical Education, Physics, Geography, Literature, Mathematics, Chemistry and Pedagogy) involving 441 participants. We used SPSS software, version 12.0 and EVOC (Ensemble of Programmes Permettant I 'Analyse des evocations), version 2000, to tabulate the closed questions and word evocations respectively. The analyzes of the results were made using governmental documents that grounded public policies in the field of Education in the country, in addition to the State and National Plans to combat sexual violence. As a result, we realized that in the three Campus students do not feel prepared to handle with cases of sexual violence and most of them never had the issue addressed in any discipline in the process of training... (Complete abstract click electronic access below)
Santos, Héllen Thaís dos [UNESP]. "A constituição da profissionalização docente em creche: narrativas autobiográficas". Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/92360.
Pełny tekst źródłaApresentam-se, nesta dissertação, os resultados de pesquisa vinculada à linha Infância e Educação do Programa de Pós-graduação em Educação da Faculdade de Ciências e Tecnologia, da Universidade Estadual Paulista “Júlio Mesquita Filho”, câmpus de Presidente Prudente-SP. Com o objetivo de analisar como se constitui a profissionalização do professor de creche foi realizado um trabalho empírico com as professoras titulares de certificação pelo menos em nível médio, que atuam na modalidade de creche, na rede municipal de Presidente Prudente-SP. Para tanto, o conceito de profissionalização docente é tratado como o processo pelo qual os professores são capazes de adquirir saberes necessários para constituir uma profissão, sendo a formação inicial o marco regulatório deste processo. A formação do professor da educação infantil é, também, discutida a fim de compreender o educar e cuidar como papel do professor de creche. As narrativas autobiográficas são evidenciadas como instrumento de pesquisa e formação de professores, elas estão baseadas no método (auto) biográfico, cujos procedimentos metodológicos permitiram coletar e analisar trajetórias de vida pessoais/profissionais para compreender como se constituiu a profissionalização do professor na creche. Como resultados são evidenciadas as práticas docentes baseadas em saberes advindos da experiência e a necessidade de associação teórico-prática na formação do professor de creche. Além disso, a pesquisa evidencia que a docência em creche está em construção e se configura como uma nova faceta da profissão docente na sociedade moderna, que ainda precisa ser “aceita” pelo professor
In this dissertation are presented the results of a research linked to the Childhood and Education line of the Education Graduate Program in Faculty of Sciences and Technology, São Paulo State University Júlio Mesquita Filho, Presidente Prudente-SP campus. Aiming to analyze the constitution of professionalization of daycare teachers, empirical work was performed with teachers, with at least mid-level certification, who act in daycare centers, in Presidente Prudente - SP. Thus, the concept of teacher professionalization is treated as the process by which teachers are able to acquire knowledge necessary to constitute a profession, considering the initial formation as the regulatory framework of this process. The formation of childhood teachers is also discussed in order to understand the educating and caring teacher's role as day care teachers. Autobiographical narratives are evidenced as a tool for research and teacher formation, that are based on the method (auto) biographical, whose methodological procedures , allowed collect and analyze trajectories of personal/professional life to understand how was the constitution of teacher professionalization in daycare centers. The results evidenced teaching practices based in knowledge experiences , and need of association of theory and practice in formation of daycare center teachers . Moreover , this research shows that teaching in daycare is under construction and is configured as a new facet of the teaching profession in modern society , which still needs to be accepted by the teacher
Porto, Marília de Paula [UNESP]. "Ação moduladora do citral e eugenol em eventos genéticos em magrófagos murinos in vitro". Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/92460.
Pełny tekst źródłaConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Devido a propriedades terapêuticas, várias plantas e seus constituintes químicos vêm sendo muitas vezes utilizados como o primeiro recurso para o tratamento de diversas doenças. Nesse contexto, compostos isolados de plantas têm sido alvos de inúmeros estudos que avaliam, além da atividade, seus possíveis mecanismos de ação. Dentre os compostos com potencial quimioprotetor, o citral e o eugenol merecem atenção devido suas estruturas químicas de monoterpeno e de composto fenólico, respectivamente, e por seus potenciais anti-inflamatório, antiparasitário e antioxidante. Considerando que mutação no DNA pode ser a primeira etapa de várias doenças, e que lesões induzidas nessa molécula podem ser prevenidas ou moduladas por compostos naturais, este estudo objetivou avaliar, pelo teste do cometa, o potencial genotóxico do citral (25, 50 e 100 Tg/mL) e do eugenol (0,31, 0,62, 1,24 e 2,48 Tg/mL), após diferentes tempos de tratamento (6, 10, 24 e 30 h) e, também, seus possíveis efeitos moduladores sobre danos induzidos no DNA pela doxorrubicina (DOX), em diferentes protocolos de tratamento (pré, pós e simultaneamente à DOX) e momentos de análise (12, 24 e 36 h), em macrófagos peritoneais de camundongos. Além disso, foi avaliado o potencial toxicogenômico do citral e do eugenol por meio da modulação da expressão dos genes NF-kB1, COX-2 e TNF-α (relacionados a processos inflamatórios) em macrófagos ativados ou não por lipopolissacarideo de bactéria (LPS). Os resultados mostraram que ambos os compostos apresentaram potencial genotóxico. No caso do citral, a genotoxicidade foi observada para as duas maiores concentrações, mas apenas no tempo de 6h; para o eugenol, o aumento de danos no DNA foi detectado para todas as concentrações, em pelo menos um momento de análise. Com relação ao potencial...
Because of the therapeutic properties, several plants and their chemical constituents have been used for treatment of various diseases. Therefore, isolated compounds from plants have been targets of numerous studies that evaluate their activity and mechanisms of action. Among compounds with chemopreventive potential, citral and eugenol have gain attention because of their chemical structures, monoterpene and phenol,respectively, and for their anti-inflammatory, antioxidant and antiparasitic potentials. Since DNA mutation is the first step for some diseases, and since the lesions induced in this molecule can be prevented or modulated by natural compounds, aim of the present study was first to evaluate the genotoxic potential of citral (25, 50 and 100 Tg/mL) and eugenol (0.31, 0.62, 1.24 and 2.48 Tg/mL) at different times after exposure (6, 10, 24 and 30 h), and then, their ability to modulate DNA damage induced by doxorubicin (DOX) at different treatment protocols (pre, post and simultaneous with DOX) and times (12, 24 and 36 h) in mice peritoneal macrophages. In addition, the toxicogenomic potential of citral and eugenol by modulating the expression of NF-KB1, COX-2 and TNF-α (related to inflammatory processes) genes in macrophages activated or not by bacterial lipopolysaccharide (LPS) was also investigated. The results showed that both compounds have genotoxic potential. In the case of citral, genotoxicity was observed for the two major concentrations, but only 6h after the exposure. For eugenol, increased DNA damage was detected for all concentrations, in at least one moment of analysis. Related to the antigenotoxicity, both citral and eugenol presented protective effects at different concentrations and treatment protocols, and the more effective activities were detected at simultaneous and pre-treatment... (Complete abstract click electronic access below)
Lemos, Marcos Vinícius Antunes de [UNESP]. "Interação genótipo ambiente para perímetro escrotal em bovinos da raça Nelore utilizando normas de reação". Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/92560.
Pełny tekst źródłaO crescente mercado de carne bovina brasileiro tem sinalizado a busca de rebanhos mais produtivos e com maiores proporções de animais precoces ao abate, de grande importância a seleção para precocidade sexual. Existem evidências que o perímetro escrotal está correlacionado, negativa e favoravelmente, com a idade ao primeiro parto de fêmeas. Portanto, a seleção para aumentar o perímetro escrotal, em longo prazo, deve levar a um aumento na precocidade sexual das fêmeas. No Brasil a pressuposição comumente assumida é a ausência de interação genótipo-ambiente (IGA) nas características de interesse econômico para a raça Nelore. Ainda são escassos os estudos de IGA para características de precocidade sexual, como o perímetro escrotal. O objetivo do presente trabalho foi quantificar a magnitude da IGA sobre o perímetro escrotal ao sobreano em machos da raça Nelore utilizando normas de reação. Foram utilizadas 31.370 medidas de machos da raça Nelore de propriedades localizadas no Sul, Centro-Oeste e Sudeste do Brasil. Os diferentes grupos ou descritores ambientais foram definidos conforme a informação de ano e estação de nascimento, fazenda de origem dos dados e grupo de manejo alimentar (nascimento, desmama e sobreano). Para a estimação dos parâmetros genéticos foi aplicado um modelo animal utilizando análises de regressão aleatória, em análises uni-característica, utilizando polinômios de Legendre como funções base. Para perímetro escrotal foram considerados a idade do animal no momento da avaliação como consequência aleatória foi considerado o efeito genético aditivo do animal. Polinômios de Legendre (de primeiro grau) regredidos sobre os grupos ambientais foram utilizados para modelar o efeito genético aditivo do animal e as (co)variâncias entre a característica estudada nos diferentes ambientes. Foram consideradas classes heterogêneas e homogêneas...
The increasing search on growing market for Brazilian Beef are related to herds more productive and availability of animals for slaughter, as consequence more significant importance for sexual precocity selection. The use of indicator's characteristics to sexual precocity in indirect selection can result in improving of reproductive efficiency of females. There is significant evidence that scrotal circumference is correlated, negatively and positively, with age at first calving females. Therefore, the selection for increasing scrotal circumference in long-term should lead to an increase of sexual precocity in females. Nowadays, several Brazilian summaries for Nellore bulls are published with amount of characteristics with focus in economically important traits, including all large data sets of animals distributed in some regions of the country. These genetics evaluations have the assumption, commonly assumed, of absence the genotype-environment interaction (GxE). Although there are few studies of GxE related to indicator's characteristics to sexual precocity, such as scrotal circumference.The objectives of this study was to verify the occurrence of genotype-environment interaction on the scrotal circumference, as well as studying genetic association between this trait in different environments, in animals of Nellore breed using the approach of reaction norms. We used information from 31,370 male Nellore property located in the south-central and southeastern Brazil. The different groups or environmental descriptors were defined according to information year and season of birth, home farm and data feed management group (birth weaning and yearling). For the estimation of genetic parameters was applied an animal model using random regression analyzes in single-trait analyzes, using Legendre polynomials as basis functions. For scrotal circumference were considered the age of the animal at the ...
Demore, Paula dos Santos [UNESP]. "Seleção assistida por marcadores moleculares microssatélites para resistência ao oídio em soja". Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/92660.
Pełny tekst źródłaConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
O oídio em soja, trata-se de uma doença praticamente presente em todos os paises produtores. Os marcadores moleculares microssatélites ou SSR (Simple Sequence Repeat) têm sido amplamente utilizados no processo de seleção assistida de genótipos de soja. Assim, o objetivo deste estudo foi obter marcadores microssatélites próximos ao gene de resistência ao oídio em soja. O estudo foi realizado em duas populações F2, oriundas de cruzamentos entre parentais contrastantes quanto à resistência ao oídio. Para o estudo, foram selecionados marcadores microssatélites a uma distância de até 42 cM ao redor do gene Rmd (resistência ao oídio). Utilizou-se o método de BSA (Bulked Segregant Analysis) na avaliação dos marcadores, para a comparação com a análise fenotípica das populações. Na análise foram utilizados dez iniciadores SSRs para as duas populações, sendo identificados quatro marcadores polimórficos para o cruzamento 1 (MGBR95-20937 x IAC-Foscarin 31) e três para o cruzamento 2 (MGBR 46/Conquista x EMBRAPA 48). Pela análise de Qui-quadrado da avaliação fenotípica, confirmou-se à segregação esperada (3:1) de um gene dominante condicionando a resistência. Os marcadores polimórficos também segregaram conforme o esperado (1:2:1) já que possuem natureza codominante. Para as populações 1 e 2, os melhores resultados foram obtidos com os marcadores Sat_366 e Sat_393, respectivamente, localizando-se a 9,41 e 12,45 cM de distância do gene, sendo considerados promissores na seleção assistida para resistência ao oidio em soja.
Powdery mildew in soybeans, it is a disease present in virtually all producing countries. The molecular markers microsatellites or SSR (Simple Sequence Repeat) have been widely used in the assisted selection of soybean genotypes. The objective of this study was to obtain microsatellites markers near the gene for resistance to powdery mildew in soybeans. The study was conducted in two populations F2, from crosses between contrasting parents about the resistance to powdery mildew. For the study, were selected microsatellites markers at a distance of 42 cM around the gene Rmd (resistance to powdery mildew). It was used the method of BSA (Bulked Segregant Analysis) in the evaluation of markers, for comparison with the phenotypic analysis of populations. In the analysis were used in ten initiators SSRs for the two populations, and identified four polymorphic markers for the crossing 1 (MGBR95-20937 x-IAC Foscarin 31) and three for the crossing 2 (EMBRAPA MGBR 46/Conquista x 48). For the analysis of chi-square of the phenotypic evaluation, it is confirmed the segregation expected (3:1) of a dominant gene conditioning the resistance. The polymorphic markers also segregation as expected (1:2:1) that have already codominante nature. For the populations 1 and 2, the best results were obtained with the markers Sat_366 and Sat_393, respectively, finding itself to 9.41 and 12.45 cM distance of the gene and are considered promising in assisted selection for resistance to soybean in powdery mildew.
Silveira, Denise Antunes da [UNESP]. "Um modelo de gestão para resíduos industriais pós-consumo". Universidade Estadual Paulista (UNESP), 2004. http://hdl.handle.net/11449/92760.
Pełny tekst źródłaCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Alguns resíduos sólidos domiciliares podem conter substâncias químicas com características tóxicas, como os metais pesados presentes em diversos materiais provenientes de resíduos industriais pós-consumo. Como exemplo, pode-se citar as lâmpadas fluorescentes, as pilhas e as baterias, que, por possuírem metais pesados em suas composições geram um alto grau de toxicidade, bioacumulação e persistência no meio ambiente, causando preocupações ambientais e prejuízos para a saúde humana. Outro resíduo industrial pós-consumo que atualmente causa enorme prejuízo ambiental, se disposto inadequadamente, são os pneus inservíveis: ainda hoje muitas carcaças de pneus inservíveis são depositadas em cursos d'água, voçorocas ou nos terrenos baldios das cidades, fator que gera, além de outros problemas, a proliferação de larvas e mosquitos. Esta pesquisa se propôs a esclarecer qual o destino final fornecido à estes resíduos industriais pós-consumo (pilhas, baterias, lâmpadas fluorescentes e pneus inservíveis) na cidade de Rio Claro/SP. Foi adotada a metodologia de aplicação de questionários em residências previamente selecionadas e em estabelecimentos que comercializam os produtos citados e, de posse dos resultados finais, elaborou-se um modelo de gestão para a correta destinação dos produtos enfocados.
Some solid domestic wastes may contain toxic chemicals, as the heavy metals present in several materials deriving from post-consumption industrial wastes. For instance, it can be mentioned the domestic batteries, the fluorescent lamps, which, because of the heavy metals in their composition, produce a high level of toxicity, bio-accumulation and persistence in the environment, causing prejudicial effects to the human health and the environemnt. Another post-consumption industrial waste that currently cause an enormous environmental damage, if disposed inadequately, are the worn out tires: currently, several frame-works of worm out tires are deposited in streams and rivers and erosion sites, that cause, amoung other problems, the proliferation of larvae and mosquitoes. This research purposed to clear what the final destination of the mentioned post-consumption industrial wastes (batteries, fluoescent lamps, worm out tires) in Rio Claro city, São Paulo State, Brazil. The application of questionnaires methodology in previously selected residences and stores which sell the above mentioned products was adopted and, considering the final results, a pattern of management for the correct destination of the reported products was archieved.
Lavorante, Luca Pallozzi [UNESP]. "Técnicas de modelagem 3D aplicadas a dados paleobatimétricos das bacias de Santos e Campos e à simulação deformacional de objetos geológicos". Universidade Estadual Paulista (UNESP), 2005. http://hdl.handle.net/11449/92860.
Pełny tekst źródłaAgência Nacional do Petróleo, Gás Natural e Biocombustíveis (ANP)
As pesquisas em geociências tendem cada vez mais a utilizar grande volume de dados heterogêneos, cuja interpretação integrada é complexa devido ao envolvimento de diferentes parâmetros, bem como de relações temporais e espaciais. As técnicas de computação gráfica e visualização científica assumem importância crescente por permitirem representar e manipular dados geológicos tal como são e estão no espaço, isto é, em 3D. Esta dissertação teve por objetivo utilizar ferramentas computacionais para modelar geometricamente e visualizar dados geológicos. Utilizando o programa GOCAD foram construídas superfícies paleobatimétricas das bacias de Santos e Campos para o meso- Neocretáceo a partir dos dados disponíveis na literatura. Sua integração com dados litológicos e estruturais em um único ambiente de visualização 3D permitiu aumentar o potencial de interpretação dos dados originalmente representados em mapas bidimensionais. Para melhor contextualizar a evolução paleogeográfica destas bacias durante a abertura do Atlântico Sul e representar analogias com ambientes de deposição atuais foram construídas superfícies batimétricas do Atlântico Sul do mesocretáceo ao recente e do Mar Vermelho. A partir da utilização de ferramentas de modelagem e visualização 3D de domínio público (VTK) foi desenvolvido um programa computacional (Tensor3D) para a simulação da deformação de objetos geológicos, desde rochas, estruturas tectônicas, domos de sal até bacias, a partir da modificação dos componentes de cisalhamento simples e puro contidos em tensores de deformação...
Research in Geosciences is currently using extensive volumes of heterogeneous data, whose integrated interpretation is complex due to the involvement of different parameters, as well as time and spatial relationships. Computer graphics and scientific visualization techniques are assuming increasing importance as they allow the representation and manipulation of geologic data exactly as they appear in 3D space. The purpose of this work is using computational tools in order to geometrically model and visualize geologic data. Using the GOCAD program, mid-Early Cretaceus paleobathymetric surfaces have been constructed for the Santos and Campos basins, based on published data. Their additional integration with lithologic and structural data in a unified 3D visualization environment, allowed an increase in the interpretative potential of data originally represented using 2D maps. In order to provide a more general context for the paleogeographic evolution of these basins during the opening of the South Atlantic Ocean, and to represent analogies with current depositional environments, paleobathymetric surfaces have been modelled for the South Atlantic Ocean, from mid- Early Cretaceous to present time, and for the present Red Sea. By using 3D open-source modelling and visualization tools (VTK), a computational program (Tensor3D) has been devoloped to simulate deformation of geologic objects, from rocks, tectonic structures, salt domes to basins. This process is controlled by modifyng simple and pure shear components contained in strain tensors... (Complete abstract, click electronic access below)
Camarinha, Pedro Ivo Mioni [UNESP]. "Mapeamento do potencial de infiltração como subsídio ao planejamento de microbacias de cabeceira: uma proposta metodológica utilizando geotecnologias". Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/92960.
Pełny tekst źródłaCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Esta pesquisa teve como objetivo principal elaborar uma proposta metodológica para gerar mapas de potencial de infiltração de caráter semi-qualitativo, em uma área de plantio de eucalipto, a Fazenda Santa Edwiges, Lorena (SP), localizada nas cabeceiras de drenagem da sub-bacia do Ribeirão Taboão. Os procedimentos baseiam-se na integração de informações cartográficas referentes à geologia, geomorfologia, geotecnia e cobertura vegetal, implementadas em ambiente SIG. O software ArcGIS® foi utilizado para análises espaciais avançadas, incluindo geoestatística, para a espacialização da porosidade total e textura do solo, e álgebra de mapas, para obter o produto final desejado. O intuito da utilização de tal metodologia foi o de relacionar os principais fatores que interferem no processo de infiltração avaliando suas peculiaridades, de modo que ao fim do trabalho pudesse ficar claro como cada elemento age dentro do geoecossistema em questão. Como a cobertura vegetal nessa área é alterada com os ciclos de plantio de eucalipto, dois cenários diferentes foram utilizados: logo após o plantio e com o eucalipto adulto. Os mapas de potencial de infiltração indicaram que as composições formadas na porção Sudeste da fazenda, combinando a geologia dos Granitóides, com solos predominantemente arenosos, com boa drenagem interna (alta porosidade) corresponderam às áreas que mais favorecem o processo de infiltração. Por outro lado, a combinação de declividades acentuadas, solos predominantemente argilosos em locais com alta densidade de linhas de escoamento e também de drenagem, caracterizara como as mais tendenciosas ao escoamento superficial. Os resultados finais puderam ser validados através de ensaios de condutividade hidráulica saturada obtidos em campo, caracterizando a viabilidade e aplicabilidade da metodologia proposta, que pode ser considerada não só uma...
This research had as main goal to create a methodology to generate semi-qualitative maps of the potential for water infiltration, in an area of eucalyptus plantations, the Farm St. Edwiges, Lorena (SP). The area is located in the headwaters zone of the Ribeirão Taboão watershed, Paraíba do Sul basin, Southeast Brazil. The procedures are based on the integration of cartographic information concerning the geology, geomorphology, geotechnical and vegetation cover, implementation in a GIS. The software ArcGIS® was used for advanced spatial analysis, including the analysis, including the geostatistics for spatialization of porosity and soil texture, and map algebra to obtain the desired final product. The purpose of this study was to correlate the main factors involved in the water infiltration evaluationg its peculiarities. As the vegetation in this area changes with the cycles of eucalyptus, two different scenarios were simulated: immediately after planting and adult eucalyptus. The maps of potential of water infiltration indicated that the southeast region of the study area, with geology composed of granitoids, sandy soils with high porosity corresponds to the areas with high infiltration potential. On the other hand, the combination of steep slopes with clay soils located in areas with high density of flow and drainage lines characterize the most popitious areas to runoff. The results can be validated through tests of hydraulic condutivity obtained in the field, characterizing the feasibility and applicability of the methodology, which can be considered not only a tool for the management of natural resources but also as an essential tools for decision making regarding the land use and occupation
Goncalves, Alexandre A. "Conflicting Frames : the dispute over the meaning of rolezinhos in Brazilian media". Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/92660.
Pełny tekst źródłaCataloged from PDF version of thesis.
Includes bibliographical references (pages 83-104).
This research analyzes the battle of frames in the controversy surrounding rolezinhos- flashmobs organized by low-income youth in Brazilian shopping malls. To analyze the framing of these events, a corpus of 4,523 online articles was compiled. These articles, published between December 7th, 2013, and February 23 rd, 2014, were investigated using Media Cloud-the system for large scale content analysis developed by the Berkman Center at Harvard and the MIT Center for Civic Media. Data from Facebook indicated which articles received more attention on the social network. A framing analysis was performed to describe the conflicting frames in the debate. The 60 most popular texts--those that attracted 55% of the social media attention in the corpus-were content analyzed. They served as an input for a hierarchical cluster analysis algorithm that grouped articles with similar frame elements. The result of the cluster analysis led to the identification of three frames: one that criminalized rolezinhos or at least tried to discourage them (arrastdo frame), another that acquitted the youth and blamed police, government, State, or society for discriminating poor citizens (apartheid frame), and a third frame that criticized both conservatives and progressives for using the controversy to push their particular agendas (middle ground frame). After finding the keywords that singled out each frame, natural language processing methods helped to describe the genesis and evolution of those frames in the overall corpus as well as the framing strategies of the main actors.
by Alexandre A. Goncalves.
S.M. in Comparative Media Studies
Phillips, Bren Andrew. "Experimental investigation of subcooled flow boiling using synchronized high speed video, infrared thermography, and particle image velocimetry". Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/92060.
Pełny tekst źródłaThis electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages [133]-138).
Subcooled flow boiling of water was experimentally investigated using high-speed video (HSV), infrared (IR) thermography, and particle image velocimetry (PIV) to generate a unique database of synchronized data. HSV allowed measurement of the bubble departure diameter. IR thermography allowed measurement of wall superheat (local distribution and surface-averaged values), heat transfer coefficient, nucleation site density, and bubble frequency. Particle image velocimetry allowed for the measurement of velocity profiles in the liquid phase for single bubble nucleation events. The tests were performed at pressures of 1.05, 1.5, and 2.0 bar and at subcoolings of 5, 10, and 15 °C. The mass flux values explored were 150-1250 kg/m2/s. The heat flux values explored were 100-1600 kW/m2. As expected, the heat transfer coefficients increased with increasing mass flux in the single-phase convection and partial boiling regions, and converged to a fully-developed boiling curve for high heat fluxes. The bubble departure diameter decreased with increasing mass flux and decreasing heat flux; in accordance with Sugrue's model. The nucleation site density increased with increasing superheat and decreasing mass flux, as predicted by Kocamustafaogullari and Ishii's model. The nucleation site density models under-predicted the nucleation site density for a given wall superheat. Wait time and frequency models did not reproduce the data accurately, and underestimated wait time by an order of magnitude. A new mechanistic model for calculating the wait time was developed that split the wall heat flux into the component that is transferred to the fluid, and the component that is transferred as sensible heat into the heater wall. Significant localized cooling was observed underneath bubbles sliding along the wall after departure from a nucleation site, an effect which should be considered in advanced models of subcooled flow boiling. The sliding bubble thermal effects were found to be insensitive to system conditions and were limited by the thermal conduction within the substrate. Bubble growth front velocities, and regions of flow influence of departing bubbles were measured with PIV. The database generated in this project can be used to inspire or validate mechanistic models and/or CFD simulations of subcooled flow boiling heat transfer.
by Bren Andrew Phillips.
Ph. D.
Joung, Young Soo. "Electric field based fabrication methods for multi-scale structured surfaces". Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/92160.
Pełny tekst źródłaCataloged from PDF version of thesis.
Includes bibliographical references (pages 217-227).
Control of micro/nano scale surface structures and properties is crucial to developing novel functional materials. From an engineering point of view, the development of scalable and economical micro/nano-fabrication methods has been in high demand. In this dissertation, electrophoretic deposition (EPD) and breakdown anodization (BDA) are examined for their potential to produce multi-scale structured surfaces. EPD uses electrophoresis to deposit thin films of nanoparticles, dispersed in suspension, onto charged or porous substrates. Depending upon the dispersion stability, the surface roughness can be modulated in order to affect the resulting wettability. BDA can be utilized to alter surface features by employing instabilities during high voltage anodization, which lead to micro scale topography. Different microporous structures are generated depending on electric potential and electrolyte temperature during BDA. A hybrid method employing EPD and BDA results in hierarchical surface structures with both nano/micro scale features. In this work EPD and BDA are utilized for the development of superhydrophobic and superhydrophilic surfaces; sample applications include anti-wetting fabric, capillarity driven flow design, and critical heat flux enhancement. In many applications it is critical to understand how moving liquid water droplets will behave when they encounter these modified surfaces. We investigate drop impingement on porous thin films produced by BDA and EPD in order to understand the effects of surface structure and chemical properties on droplet dynamics. Using dimensional analysis we've discovered a novel dimensionless parameter, named the Washburn- Reynolds number, which can predict the droplet impingement modes. Intriguingly we've also discovered that under certain conditions drop impingement results in gas trapped in the spreading droplet, leading to the generation of aerosol above the droplet when the gas bubbles burst. The Washburn-Reynolds number also largely dictates the aerosol generation process. Our results inform the understanding of dynamic interactions between porous surfaces and liquid drops for applications ranging from droplet microfluidics to aerosol generators. In summary, EPD and BDA provide promising micro and nano-scale fabrication technologies with reasonable control of surface morphology and properties in a cost-effective and time-effective and scalable.
by Young Soo Joung.
Ph. D.
Peykov, Daniel. "The effects of capillarity on photonic crystal selective emitters". Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/92960.
Pełny tekst źródłaThis electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 60-64).
Photonic crystals offer an unparalleled control over optical properties and are ideal candidates as high efficiency selective emitters. They are, however, known to degrade at elevated temperatures through a number of processes, with one of the most notable being surface evolution by capillary forces. By comprehensively simulating the morphological and optical effects of this phenomenon, in the form of surface diffusion, vapor transport, and grain boundary grooving, this thesis seeks to understand its consequences and attempts to pinpoint methodologies that may prevent it. It was shown that while grain boundary grooves have a negligible effect on photonic crystal structures, vapor transport and surface diffusion may be significant. Indeed, vapor transport was found to progressively reduce the dimensions of photonic crystal cavities, and thus slightly alter their optical properties. Conversely, surface diffusion gradually closed o these cavities, thereby eliminating coupling into their resonant modes, and eradicating their selective emission capabilities. Changes to the shape of these photonic crystal structures that decreased their curvature and removed discontinuities were found to be beneficial in inhibiting degradation by capillarity, and an optimized structure that displays both higher efficiency and greater stability over time was ultimately theorized.
by Daniel Peykov.
S.M.
Ikefuti, Michelle Venâncio. "Concepções de licenciandos sobre violência sexual e políticas educacionais /". Presidente Prudente : [s.n.], 2012. http://hdl.handle.net/11449/92260.
Pełny tekst źródłaBanca: Maria Angela Mattar Yunes
Banca: Maria de Fátima Salum Moreira
Resumo: O presente trabalho vinculado à Linha de Pesquisa Processos Formativos, Diferença e Valores, no Programa de Pós-Graduação em Educação da Universidade Estadual Paulista, campus de Presidente Prudente-SP, teve como objetivos identificar o nível de conhecimento que os futuros professores dos cursos de licenciaturas de três campus da Unesp têm acerca da violência sexual e temas afins, bem como elucidar se esta temática é trabalhada dentro dessas faculdades. Dentre as violências domésticas que podem ser cometidas contra crianças e adolescentes, a violência sexual é uma das modalidades mais difíceis de serem detectadas, sendo que a maioria das situações ocorre dentro da casa da vítima, e é cometida muitas vezes por alguém que ela conhece e confia. Diante disso, e sabendo que a escola ocupa um tempo importante na vida das crianças e adolescentes, destacamos que o professor tem um papel fundamental na prevenção, revelação e intervenção de casos de abuso e exploração sexual. A pesquisa foi desenvolvida nos campus da UNESP (Araraquara, Presidente Prudente e São José do Rio Preto), sendo que aplicamos um questionário que contou com a participação dos alunos dos últimos anos de oito cursos de licenciatura (Biologia, Educação Física, Física, Geografia, Letras, Matemática, Pedagogia e Química) totalizando 441 participantes. Foram utilizados os softwares SPSS, versão 12.0 e o EVOC (Ensemble de Programmes Permettant I' Analyse dês Évocations), versão 2000, para tabular as questões fechadas e as evocações de palavras respectivamente. As análises dos resultados foram feitas utilizando os documentos governamentais que regem a área de Educação no país, além dos Planos Estadual e Nacional de enfrentamento à violência sexual. Como resultados, percebemos que nas três unidades os alunos não se sentem preparados para lidar com casos de violência sexual... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: This study is connected with the research line "Formative processes, differences and values" at the Graduate Studies in Education at UNESP, Campus of Presidente Prudente. The research aimed to identify the level of knowledge that future teachers of undergraduate courses of three Campus at Unesp have about the sexual violence and related issues, and to clarify whether this theme was discussed during their course in these Universities. Amongst the domestic violence that can be committed against children, sexual violence is one of the methods more difficult to detect, and most situations occurs inside the victim's home, and it is often committed by someone he knows and trusts. Given this, and knowing that the school occupies an important moment in the lives of children and adolescents, we emphasize that the teacher has a key role in prevention, intervention and revelation of abuse and sexual exploitation. It was developed at the Campus of Araraquara, Presidente Prudente and São José do Rio Preto, and it was applied a questionnaire with students attending the last year of 8 undergraduate courses (Biology, Physical Education, Physics, Geography, Literature, Mathematics, Chemistry and Pedagogy) involving 441 participants. We used SPSS software, version 12.0 and EVOC (Ensemble of Programmes Permettant I 'Analyse des evocations), version 2000, to tabulate the closed questions and word evocations respectively. The analyzes of the results were made using governmental documents that grounded public policies in the field of Education in the country, in addition to the State and National Plans to combat sexual violence. As a result, we realized that in the three Campus students do not feel prepared to handle with cases of sexual violence and most of them never had the issue addressed in any discipline in the process of training... (Complete abstract click electronic access below)
Mestre
Porto, Marília de Paula. "Ação moduladora do citral e eugenol em eventos genéticos em magrófagos murinos in vitro /". Botucatu : [s.n.], 2012. http://hdl.handle.net/11449/92460.
Pełny tekst źródłaCoorientador: Glenda Nicioli da Silva
Banca: Luís Fernando Barbisan
Banca: Denise Crispim Tavares
Resumo: Devido a propriedades terapêuticas, várias plantas e seus constituintes químicos vêm sendo muitas vezes utilizados como o primeiro recurso para o tratamento de diversas doenças. Nesse contexto, compostos isolados de plantas têm sido alvos de inúmeros estudos que avaliam, além da atividade, seus possíveis mecanismos de ação. Dentre os compostos com potencial quimioprotetor, o citral e o eugenol merecem atenção devido suas estruturas químicas de monoterpeno e de composto fenólico, respectivamente, e por seus potenciais anti-inflamatório, antiparasitário e antioxidante. Considerando que mutação no DNA pode ser a primeira etapa de várias doenças, e que lesões induzidas nessa molécula podem ser prevenidas ou moduladas por compostos naturais, este estudo objetivou avaliar, pelo teste do cometa, o potencial genotóxico do citral (25, 50 e 100 Tg/mL) e do eugenol (0,31, 0,62, 1,24 e 2,48 Tg/mL), após diferentes tempos de tratamento (6, 10, 24 e 30 h) e, também, seus possíveis efeitos moduladores sobre danos induzidos no DNA pela doxorrubicina (DOX), em diferentes protocolos de tratamento (pré, pós e simultaneamente à DOX) e momentos de análise (12, 24 e 36 h), em macrófagos peritoneais de camundongos. Além disso, foi avaliado o potencial toxicogenômico do citral e do eugenol por meio da modulação da expressão dos genes NF-kB1, COX-2 e TNF-α (relacionados a processos inflamatórios) em macrófagos ativados ou não por lipopolissacarideo de bactéria (LPS). Os resultados mostraram que ambos os compostos apresentaram potencial genotóxico. No caso do citral, a genotoxicidade foi observada para as duas maiores concentrações, mas apenas no tempo de 6h; para o eugenol, o aumento de danos no DNA foi detectado para todas as concentrações, em pelo menos um momento de análise. Com relação ao potencial... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Because of the therapeutic properties, several plants and their chemical constituents have been used for treatment of various diseases. Therefore, isolated compounds from plants have been targets of numerous studies that evaluate their activity and mechanisms of action. Among compounds with chemopreventive potential, citral and eugenol have gain attention because of their chemical structures, monoterpene and phenol,respectively, and for their anti-inflammatory, antioxidant and antiparasitic potentials. Since DNA mutation is the first step for some diseases, and since the lesions induced in this molecule can be prevented or modulated by natural compounds, aim of the present study was first to evaluate the genotoxic potential of citral (25, 50 and 100 Tg/mL) and eugenol (0.31, 0.62, 1.24 and 2.48 Tg/mL) at different times after exposure (6, 10, 24 and 30 h), and then, their ability to modulate DNA damage induced by doxorubicin (DOX) at different treatment protocols (pre, post and simultaneous with DOX) and times (12, 24 and 36 h) in mice peritoneal macrophages. In addition, the toxicogenomic potential of citral and eugenol by modulating the expression of NF-KB1, COX-2 and TNF-α (related to inflammatory processes) genes in macrophages activated or not by bacterial lipopolysaccharide (LPS) was also investigated. The results showed that both compounds have genotoxic potential. In the case of citral, genotoxicity was observed for the two major concentrations, but only 6h after the exposure. For eugenol, increased DNA damage was detected for all concentrations, in at least one moment of analysis. Related to the antigenotoxicity, both citral and eugenol presented protective effects at different concentrations and treatment protocols, and the more effective activities were detected at simultaneous and pre-treatment... (Complete abstract click electronic access below)
Mestre
Damatto, Ricardo Luiz. "Caracterização morfológica, bioquímica e molecular do músculo esquelético sóleo de ratos espontaneamente hipertensos com insuficiência cardíaca /". Botucatu : [s.n.], 2010. http://hdl.handle.net/11449/92160.
Pełny tekst źródłaAbstract: Heart failure (HF) is characterized by limited exercise tolerance due to increased muscle fatigue and impaired endurance. Besides cardiac and pulmonary dysfunction, intrinsic skeletal muscle abnormalities have been shown to be involved on reduced exercise tolerance. muscle mass loss and a shift in myosin heavy chain (MyHC) isoforms have been frequently observed in peripheral and respiratory skeletal muscles during HF. The pathophysiological mechanisms and intracellular pathways responsible for muscle changes are not completely defined. We observed that myogenic regulatory factors expression and myostation/follistatin pathway modulate muscle trophism and MyHC isoforms in experimental aortic stenosis- and myocardial infarction-induced HF. The spontaneously hypertensive rat (SHR) is often used in HF studies. These rats develop systemic arterial hypertension and left ventricular hypertrophy early and HF at 18-22 month-age approximately. To the best of our knowledgement, there is not study on skeletal muscle evaluation in SHR with HF. The aim of this study was to characterize skeletal myopathy of SHR with HF by evaluating soleus muscle morphology, MyHC isoforms, and gene and protein expression of myogenic regulatory factors, myostatin, and follistatin. Eighteen month-old spontaneously hypertensive rats were evaluated twice a week to identify HF clinical features such as taquipnea, weight loss, and apathy. After detecting HF, rats were subjected to transthoracic echocardiogram. During euthanasia, we evaluated pathological evidences of HF such as pleuropericardial effusion, ascites, left atrial thrombi, right ventricular hypertrophy, and lung congestion. Agematched Wistar-Kyoto rats used as controls. Soleus morphology was analyzed in haematoxyin and eosin and picro-sirius red stained sections, and MyHC isoforms were evaluated by protein... (Complete abstract click electronic access below)
Orientador: Marina Politi Okoshi
Coorientador: Maeli Dal Pai Silva
Banca: Luiz Shiguero Matsubara
Banca: José Francisco Saraiva
Mestre
Lavorante, Luca Pallozzi. "Técnicas de modelagem 3D aplicadas a dados paleobatimétricos das bacias de Santos e Campos e à simulação deformacional de objetos geológicos /". Rio Claro : [s.n.], 2005. http://hdl.handle.net/11449/92860.
Pełny tekst źródłaBanca: Ricardo Latgé Milward de Azevedo
Banca: Cláudio Coelho de Lima
Resumo: As pesquisas em geociências tendem cada vez mais a utilizar grande volume de dados heterogêneos, cuja interpretação integrada é complexa devido ao envolvimento de diferentes parâmetros, bem como de relações temporais e espaciais. As técnicas de computação gráfica e visualização científica assumem importância crescente por permitirem representar e manipular dados geológicos tal como são e estão no espaço, isto é, em 3D. Esta dissertação teve por objetivo utilizar ferramentas computacionais para modelar geometricamente e visualizar dados geológicos. Utilizando o programa GOCAD foram construídas superfícies paleobatimétricas das bacias de Santos e Campos para o meso- Neocretáceo a partir dos dados disponíveis na literatura. Sua integração com dados litológicos e estruturais em um único ambiente de visualização 3D permitiu aumentar o potencial de interpretação dos dados originalmente representados em mapas bidimensionais. Para melhor contextualizar a evolução paleogeográfica destas bacias durante a abertura do Atlântico Sul e representar analogias com ambientes de deposição atuais foram construídas superfícies batimétricas do Atlântico Sul do mesocretáceo ao recente e do Mar Vermelho. A partir da utilização de ferramentas de modelagem e visualização 3D de domínio público (VTK) foi desenvolvido um programa computacional (Tensor3D) para a simulação da deformação de objetos geológicos, desde rochas, estruturas tectônicas, domos de sal até bacias, a partir da modificação dos componentes de cisalhamento simples e puro contidos em tensores de deformação... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Research in Geosciences is currently using extensive volumes of heterogeneous data, whose integrated interpretation is complex due to the involvement of different parameters, as well as time and spatial relationships. Computer graphics and scientific visualization techniques are assuming increasing importance as they allow the representation and manipulation of geologic data exactly as they appear in 3D space. The purpose of this work is using computational tools in order to geometrically model and visualize geologic data. Using the GOCAD program, mid-Early Cretaceus paleobathymetric surfaces have been constructed for the Santos and Campos basins, based on published data. Their additional integration with lithologic and structural data in a unified 3D visualization environment, allowed an increase in the interpretative potential of data originally represented using 2D maps. In order to provide a more general context for the paleogeographic evolution of these basins during the opening of the South Atlantic Ocean, and to represent analogies with current depositional environments, paleobathymetric surfaces have been modelled for the South Atlantic Ocean, from mid- Early Cretaceous to present time, and for the present Red Sea. By using 3D open-source modelling and visualization tools (VTK), a computational program (Tensor3D) has been devoloped to simulate deformation of geologic objects, from rocks, tectonic structures, salt domes to basins. This process is controlled by modifyng simple and pure shear components contained in strain tensors... (Complete abstract, click electronic access below)
Mestre
Farhat, Ian Anderson Guimarães Konopczyk Maluf. "Modificação de superfícies de zircônia empregada a restaurações sem metais /". Araraquara, 2013. http://hdl.handle.net/11449/92060.
Pełny tekst źródłaBanca: Marco Antonio Bottino
Banca: Luís Augusto Sousa Marques da Rocha
Resumo: A Odontologia ainda não apresenta recomendação específica quanto ao tratamento adequado da superfície de cerâmicas a base de zircônia, a fim de melhorar sua adesão à dentina. Esta pesquisa estudou as propriedades Físico- Químicas dos diferentes tratamentos de superfície aplicados a corpos de prova confeccionados em zircônia estabilizados por ítria (Lava Frame Y-TZP, 3M ESPE), utilizados em restaurações sem metais. Foram aplicados diferentes condicionamentos ácidos (Ácido Fluorídrico entre outros ácidos) em sua superfície e o efeito da irradiação por feixe de laser Yb:YAG. Para a avaliação da união cerâmica/dentina foram realizados ensaios mecânicos de cisalhamento por extrusão, empregando-se corpos de prova cimentados com cimento resinoso (Panavia F, Kuraray Medical Inc., Okayama, Japan), em discos de dentina bovina. Os corpos de prova foram selecionados aleatoriamente para análise de superfície empregando-se microscopia eletrônica de varredura (MEV) antes de qualquer modificação superficial, após as modificações de superfície e após os ensaios mecânicos, e Difração de raios X, a fim de se observar a fase da zircônia existente em cada amostra
Abstract: Dentistry does not present specific recommendation regarding the appropriate treatment of surface of the zirconia based ceramics in order to improve their adhesion to dentin. This research studied the Physical-Chemical properties of various surface treatments applied to specimens made of yttria-stabilized zirconia (Lava Frame Y-TZP, 3M ESPE), used in metal-free restorations. Will apply different conditioning acids (Hydrofluoric Acid and other acids) on the surface and the effect of irradiation by the laser Yb:YAG beam. To evaluate the ceramic / dentin union were performed mechanical tests shear extrusion, using specimens cemented with resin cement (Panavia F, Kuraray Medical Inc., Okayama, Japan) in bovine dentin discs. Specimens are randomly selected for surface analysis employing electron microscopy (SEM) before any surface modification, after the surface modifications and after the mechanical tests, and X-ray diffraction, to identify the phase of zirconia in each sample
Mestre
Demore, Paula dos Santos. "Seleção assistida por marcadores moleculares microssatélites para resistência ao oídio em soja /". Jaboticabal : [s.n.], 2008. http://hdl.handle.net/11449/92660.
Pełny tekst źródłaAbstract: Powdery mildew in soybeans, it is a disease present in virtually all producing countries. The molecular markers microsatellites or SSR (Simple Sequence Repeat) have been widely used in the assisted selection of soybean genotypes. The objective of this study was to obtain microsatellites markers near the gene for resistance to powdery mildew in soybeans. The study was conducted in two populations F2, from crosses between contrasting parents about the resistance to powdery mildew. For the study, were selected microsatellites markers at a distance of 42 cM around the gene Rmd (resistance to powdery mildew). It was used the method of BSA (Bulked Segregant Analysis) in the evaluation of markers, for comparison with the phenotypic analysis of populations. In the analysis were used in ten initiators SSRs for the two populations, and identified four polymorphic markers for the crossing 1 (MGBR95-20937 x-IAC Foscarin 31) and three for the crossing 2 (EMBRAPA MGBR 46/Conquista x 48). For the analysis of chi-square of the phenotypic evaluation, it is confirmed the segregation expected (3:1) of a dominant gene conditioning the resistance. The polymorphic markers also segregation as expected (1:2:1) that have already codominante nature. For the populations 1 and 2, the best results were obtained with the markers Sat_366 and Sat_393, respectively, finding itself to 9.41 and 12.45 cM distance of the gene and are considered promising in assisted selection for resistance to soybean in powdery mildew.
Orientador: Antonio Orlando Di Mauro
Coorientadora: Sandra Helena Unêda Trevisoli
Banca: Eduardo Antonio Gavioli
Banca: João Carlos de Oliveira
Mestre
Silveira, Denise Antunes da. "Um modelo de gestão para resíduos industriais pós-consumo /". Rio Claro : [s.n.], 2004. http://hdl.handle.net/11449/92760.
Pełny tekst źródłaBanca: Eugênio Foresti
Paulo Milton Barbosa Landim
Título do folheto: O pneu chorão / Sandra Aymone 24 p.
Resumo: Alguns resíduos sólidos domiciliares podem conter substâncias químicas com características tóxicas, como os metais pesados presentes em diversos materiais provenientes de resíduos industriais pós-consumo. Como exemplo, pode-se citar as lâmpadas fluorescentes, as pilhas e as baterias, que, por possuírem metais pesados em suas composições geram um alto grau de toxicidade, bioacumulação e persistência no meio ambiente, causando preocupações ambientais e prejuízos para a saúde humana. Outro resíduo industrial pós-consumo que atualmente causa enorme prejuízo ambiental, se disposto inadequadamente, são os pneus inservíveis: ainda hoje muitas carcaças de pneus inservíveis são depositadas em cursos d'água, voçorocas ou nos terrenos baldios das cidades, fator que gera, além de outros problemas, a proliferação de larvas e mosquitos. Esta pesquisa se propôs a esclarecer qual o destino final fornecido à estes resíduos industriais pós-consumo (pilhas, baterias, lâmpadas fluorescentes e pneus inservíveis) na cidade de Rio Claro/SP. Foi adotada a metodologia de aplicação de questionários em residências previamente selecionadas e em estabelecimentos que comercializam os produtos citados e, de posse dos resultados finais, elaborou-se um modelo de gestão para a correta destinação dos produtos enfocados.
Abstract: Some solid domestic wastes may contain toxic chemicals, as the heavy metals present in several materials deriving from post-consumption industrial wastes. For instance, it can be mentioned the domestic batteries, the fluorescent lamps, which, because of the heavy metals in their composition, produce a high level of toxicity, bio-accumulation and persistence in the environment, causing prejudicial effects to the human health and the environemnt. Another post-consumption industrial waste that currently cause an enormous environmental damage, if disposed inadequately, are the worn out tires: currently, several frame-works of worm out tires are deposited in streams and rivers and erosion sites, that cause, amoung other problems, the proliferation of larvae and mosquitoes. This research purposed to clear what the final destination of the mentioned post-consumption industrial wastes (batteries, fluoescent lamps, worm out tires) in Rio Claro city, São Paulo State, Brazil. The application of questionnaires methodology in previously selected residences and stores which sell the above mentioned products was adopted and, considering the final results, a pattern of management for the correct destination of the reported products was archieved.
Mestre
Santos, Héllen Thaís dos. "A constituição da profissionalização docente em creche : narrativas autobiográficas /". Presidente Prudente, 2013. http://hdl.handle.net/11449/92360.
Pełny tekst źródłaBanca: Pedro Guilherme Rocha dos Reis
Banca: Fátima Aparecida Dias Gomes Marin
Resumo: Apresentam-se, nesta dissertação, os resultados de pesquisa vinculada à linha "Infância e Educação" do Programa de Pós-graduação em Educação da Faculdade de Ciências e Tecnologia, da Universidade Estadual Paulista "Júlio Mesquita Filho", câmpus de Presidente Prudente-SP. Com o objetivo de analisar como se constitui a profissionalização do professor de creche foi realizado um trabalho empírico com as professoras titulares de certificação pelo menos em nível médio, que atuam na modalidade de creche, na rede municipal de Presidente Prudente-SP. Para tanto, o conceito de profissionalização docente é tratado como o processo pelo qual os professores são capazes de adquirir saberes necessários para constituir uma profissão, sendo a formação inicial o marco regulatório deste processo. A formação do professor da educação infantil é, também, discutida a fim de compreender o educar e cuidar como papel do professor de creche. As narrativas autobiográficas são evidenciadas como instrumento de pesquisa e formação de professores, elas estão baseadas no método (auto) biográfico, cujos procedimentos metodológicos permitiram coletar e analisar trajetórias de vida pessoais/profissionais para compreender como se constituiu a profissionalização do professor na creche. Como resultados são evidenciadas as práticas docentes baseadas em saberes advindos da experiência e a necessidade de associação teórico-prática na formação do professor de creche. Além disso, a pesquisa evidencia que a docência em creche está em construção e se configura como uma nova faceta da profissão docente na sociedade moderna, que ainda precisa ser "aceita" pelo professor
Abstract: In this dissertation are presented the results of a research linked to the "Childhood and Education" line of the Education Graduate Program in Faculty of Sciences and Technology, São Paulo State University "Júlio Mesquita Filho", Presidente Prudente-SP campus. Aiming to analyze the constitution of professionalization of daycare teachers, empirical work was performed with teachers, with at least mid-level certification, who act in daycare centers, in Presidente Prudente - SP. Thus, the concept of teacher professionalization is treated as the process by which teachers are able to acquire knowledge necessary to constitute a profession, considering the initial formation as the regulatory framework of this process. The formation of childhood teachers is also discussed in order to understand the educating and caring teacher's role as day care teachers. Autobiographical narratives are evidenced as a tool for research and teacher formation, that are based on the method (auto) biographical, whose methodological procedures , allowed collect and analyze trajectories of personal/professional life to understand how was the constitution of teacher professionalization in daycare centers. The results evidenced teaching practices based in knowledge experiences , and need of association of theory and practice in formation of daycare center teachers . Moreover , this research shows that teaching in daycare is under construction and is configured as a new facet of the teaching profession in modern society , which still needs to be "accepted" by the teacher
Mestre
Camarinha, Pedro Ivo Mioni. "Mapeamento do potencial de infiltração como subsídio ao planejamento de microbacias de cabeceira : uma proposta metodológica utilizando geotecnologias /". Bauru : [s.n.], 2011. http://hdl.handle.net/11449/92960.
Pełny tekst źródłaBanca: Paulo Valladares Soares
Banca: George de Paula Bernardes
Resumo: Esta pesquisa teve como objetivo principal elaborar uma proposta metodológica para gerar mapas de potencial de infiltração de caráter semi-qualitativo, em uma área de plantio de eucalipto, a Fazenda Santa Edwiges, Lorena (SP), localizada nas cabeceiras de drenagem da sub-bacia do Ribeirão Taboão. Os procedimentos baseiam-se na integração de informações cartográficas referentes à geologia, geomorfologia, geotecnia e cobertura vegetal, implementadas em ambiente SIG. O software ArcGIS® foi utilizado para análises espaciais avançadas, incluindo geoestatística, para a espacialização da porosidade total e textura do solo, e álgebra de mapas, para obter o produto final desejado. O intuito da utilização de tal metodologia foi o de relacionar os principais fatores que interferem no processo de infiltração avaliando suas peculiaridades, de modo que ao fim do trabalho pudesse ficar claro como cada elemento age dentro do geoecossistema em questão. Como a cobertura vegetal nessa área é alterada com os ciclos de plantio de eucalipto, dois cenários diferentes foram utilizados: logo após o plantio e com o eucalipto adulto. Os mapas de potencial de infiltração indicaram que as composições formadas na porção Sudeste da fazenda, combinando a geologia dos Granitóides, com solos predominantemente arenosos, com boa drenagem interna (alta porosidade) corresponderam às áreas que mais favorecem o processo de infiltração. Por outro lado, a combinação de declividades acentuadas, solos predominantemente argilosos em locais com alta densidade de linhas de escoamento e também de drenagem, caracterizara como as mais tendenciosas ao escoamento superficial. Os resultados finais puderam ser validados através de ensaios de condutividade hidráulica saturada obtidos em campo, caracterizando a viabilidade e aplicabilidade da metodologia proposta, que pode ser considerada não só uma... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: This research had as main goal to create a methodology to generate semi-qualitative maps of the potential for water infiltration, in an area of eucalyptus plantations, the Farm St. Edwiges, Lorena (SP). The area is located in the headwaters zone of the Ribeirão Taboão watershed, Paraíba do Sul basin, Southeast Brazil. The procedures are based on the integration of cartographic information concerning the geology, geomorphology, geotechnical and vegetation cover, implementation in a GIS. The software ArcGIS® was used for advanced spatial analysis, including the analysis, including the geostatistics for spatialization of porosity and soil texture, and map algebra to obtain the desired final product. The purpose of this study was to correlate the main factors involved in the water infiltration evaluationg its peculiarities. As the vegetation in this area changes with the cycles of eucalyptus, two different scenarios were simulated: immediately after planting and adult eucalyptus. The maps of potential of water infiltration indicated that the southeast region of the study area, with geology composed of granitoids, sandy soils with high porosity corresponds to the areas with high infiltration potential. On the other hand, the combination of steep slopes with clay soils located in areas with high density of flow and drainage lines characterize the most popitious areas to runoff. The results can be validated through tests of hydraulic condutivity obtained in the field, characterizing the feasibility and applicability of the methodology, which can be considered not only a tool for the management of natural resources but also as an essential tools for decision making regarding the land use and occupation
Mestre
Lemos, Marcos Vinícius Antunes de. "Interação genótipo ambiente para perímetro escrotal em bovinos da raça Nelore utilizando normas de reação /". Jaboticabal, 2013. http://hdl.handle.net/11449/92560.
Pełny tekst źródłaBanca: Henrique Nunes Oliveira
Banca: Arthur dos Santos Mascioli
Resumo: O crescente mercado de carne bovina brasileiro tem sinalizado a busca de rebanhos mais produtivos e com maiores proporções de animais precoces ao abate, de grande importância a seleção para precocidade sexual. Existem evidências que o perímetro escrotal está correlacionado, negativa e favoravelmente, com a idade ao primeiro parto de fêmeas. Portanto, a seleção para aumentar o perímetro escrotal, em longo prazo, deve levar a um aumento na precocidade sexual das fêmeas. No Brasil a pressuposição comumente assumida é a ausência de interação genótipo-ambiente (IGA) nas características de interesse econômico para a raça Nelore. Ainda são escassos os estudos de IGA para características de precocidade sexual, como o perímetro escrotal. O objetivo do presente trabalho foi quantificar a magnitude da IGA sobre o perímetro escrotal ao sobreano em machos da raça Nelore utilizando normas de reação. Foram utilizadas 31.370 medidas de machos da raça Nelore de propriedades localizadas no Sul, Centro-Oeste e Sudeste do Brasil. Os diferentes grupos ou descritores ambientais foram definidos conforme a informação de ano e estação de nascimento, fazenda de origem dos dados e grupo de manejo alimentar (nascimento, desmama e sobreano). Para a estimação dos parâmetros genéticos foi aplicado um modelo animal utilizando análises de regressão aleatória, em análises uni-característica, utilizando polinômios de Legendre como funções base. Para perímetro escrotal foram considerados a idade do animal no momento da avaliação como consequência aleatória foi considerado o efeito genético aditivo do animal. Polinômios de Legendre (de primeiro grau) regredidos sobre os grupos ambientais foram utilizados para modelar o efeito genético aditivo do animal e as (co)variâncias entre a característica estudada nos diferentes ambientes. Foram consideradas classes heterogêneas e homogêneas ...
Abstract: The increasing search on growing market for Brazilian Beef are related to herds more productive and availability of animals for slaughter, as consequence more significant importance for sexual precocity selection. The use of indicator's characteristics to sexual precocity in indirect selection can result in improving of reproductive efficiency of females. There is significant evidence that scrotal circumference is correlated, negatively and positively, with age at first calving females. Therefore, the selection for increasing scrotal circumference in long-term should lead to an increase of sexual precocity in females. Nowadays, several Brazilian summaries for Nellore bulls are published with amount of characteristics with focus in economically important traits, including all large data sets of animals distributed in some regions of the country. These genetics evaluations have the assumption, commonly assumed, of absence the genotype-environment interaction (GxE). Although there are few studies of GxE related to indicator's characteristics to sexual precocity, such as scrotal circumference.The objectives of this study was to verify the occurrence of genotype-environment interaction on the scrotal circumference, as well as studying genetic association between this trait in different environments, in animals of Nellore breed using the approach of reaction norms. We used information from 31,370 male Nellore property located in the south-central and southeastern Brazil. The different groups or environmental descriptors were defined according to information year and season of birth, home farm and data feed management group (birth weaning and yearling). For the estimation of genetic parameters was applied an animal model using random regression analyzes in single-trait analyzes, using Legendre polynomials as basis functions. For scrotal circumference were considered the age of the animal at the ...
Mestre
MARCHESI, MARTINA ELENA. "Lo sfruttamento delle vulnerabilità sistemiche da parte delle reti della tratta lavorativa in Europa: il caso del settore agricolo italiano". Doctoral thesis, Università Cattolica del Sacro Cuore, 2021. http://hdl.handle.net/10280/92060.
Pełny tekst źródłaLabour trafficking in Europe is a serious crime against persons, violating their fundamental human rights. Existing research primarily focuses on the victims, while data on offenders and the manner in which they exploit vulnerabilities is less developed. Recent trends in criminological literature are highlighting how the past lack of research is related to the lack of robust data, but also to traditional rigid approaches with exception to few extreme cases. On the contrary, they call for more flexible concepts recognising that labour trafficking is not only the product of offenders’ will, but has deep roots embedded in the socioeconomic system. Elaborating on these indications, this research focuses on the Italian agriculture sector, which has not yet been examined in literature from a criminological perspective, with the aim to understand the mechanisms through which labour trafficking originates and develops. This choice has been made because the characteristics particular to Italy make labour trafficking in agriculture central to the debate within the country; and because Italy shares some characteristics with other European countries, so some lessons learnt from this case can be discussed in light of the international debate on labour trafficking. First, a macro-analysis examines how the structural factors associated in the international literature with labour trafficking take shape in the Italian context. The results show that the system itself seems to create a fertile ground for labour trafficking to develop and maintain: migrant workers’ vulnerability is inherent in the current migration regulatory framework; the agrifood supply chain makes it necessary for producers to lower the cost of workforce; and the current legal system based on the repression of abusive conducts seen as exceptional events proves ineffective. Second, a meso-analysis at organisation/network level describes the general characteristics of labour trafficking networks in Italy, and then zooms in four case studies selected through a rational systematic method to identify the main features, modalities, and relational organisation of the crime commission, and how the exploitative condition of the victims is developed and maintained. The results show that in the four case studies the trafficking networks develop and adapt to the opportunities offered by the legal system. The results are finally discussed in light of the international debate on labour trafficking, and the lessons learned from the case of Italy.
MARCHESI, MARTINA ELENA. "Lo sfruttamento delle vulnerabilità sistemiche da parte delle reti della tratta lavorativa in Europa: il caso del settore agricolo italiano". Doctoral thesis, Università Cattolica del Sacro Cuore, 2021. http://hdl.handle.net/10280/92060.
Pełny tekst źródłaLabour trafficking in Europe is a serious crime against persons, violating their fundamental human rights. Existing research primarily focuses on the victims, while data on offenders and the manner in which they exploit vulnerabilities is less developed. Recent trends in criminological literature are highlighting how the past lack of research is related to the lack of robust data, but also to traditional rigid approaches with exception to few extreme cases. On the contrary, they call for more flexible concepts recognising that labour trafficking is not only the product of offenders’ will, but has deep roots embedded in the socioeconomic system. Elaborating on these indications, this research focuses on the Italian agriculture sector, which has not yet been examined in literature from a criminological perspective, with the aim to understand the mechanisms through which labour trafficking originates and develops. This choice has been made because the characteristics particular to Italy make labour trafficking in agriculture central to the debate within the country; and because Italy shares some characteristics with other European countries, so some lessons learnt from this case can be discussed in light of the international debate on labour trafficking. First, a macro-analysis examines how the structural factors associated in the international literature with labour trafficking take shape in the Italian context. The results show that the system itself seems to create a fertile ground for labour trafficking to develop and maintain: migrant workers’ vulnerability is inherent in the current migration regulatory framework; the agrifood supply chain makes it necessary for producers to lower the cost of workforce; and the current legal system based on the repression of abusive conducts seen as exceptional events proves ineffective. Second, a meso-analysis at organisation/network level describes the general characteristics of labour trafficking networks in Italy, and then zooms in four case studies selected through a rational systematic method to identify the main features, modalities, and relational organisation of the crime commission, and how the exploitative condition of the victims is developed and maintained. The results show that in the four case studies the trafficking networks develop and adapt to the opportunities offered by the legal system. The results are finally discussed in light of the international debate on labour trafficking, and the lessons learned from the case of Italy.
Leiva, Cabanillas Jorge. "Fundamentación y diseño de un modelo de intervención socioeducativa desde una perspectiva constructivista, para su aplicación en organizaciones productivas o de servicios. Estudio de su aplicación e impacto en una empresa". Doctoral thesis, Universitat Ramon Llull, 2008. http://hdl.handle.net/10803/9260.
Pełny tekst źródłaEl disseny del model assumeix aquestes distincions i estableix un creuament amb els desenvolupaments post-analítics del gir lingüístic en la comprensió performativa del llenguatge, per a la concepció de l'organització com una xarxa de converses. Assumeix el caràcter emergent de la conducta lingüística en l'acoblament amb el medi. aquest acoblament estructural s'entén enactivament mitjançant l'ús recursiu del llenguatge, per a generar compromisos vers un aprenentatge que integri les persones al sistema.
El disseny reencuadra la investigació-acció utilitzant eines de cibernètica de primer ordre en una cibernètica de segon ordre, mitjançant converses recurrents per articular les metes de l'organització amb l'espai relacional. Incorpora metodologies de primera persona performatives i comunicacionals com eines per integrar la dimensió dels valors d'un mateix amb les metes de l'organització amb l'objectiu de reproduir-la mitjançant la integració social. Opera mitjançant el treball en grup per tal que les converses es situïn en la segona persona, (jo-altres), per tal de possibilitar l'emergència de la primera persona.
Assumeix la distinció de les dues dimensiones del ésser cognitiu (Varela 2000): una d'enllaç mitjançant el llenguatge per la coderiva del sistema amb el medi, i una dimensió d'excedent de significació, és a dir, d'interpretació per a la reformulació de la experiència en el llenguatge (narrativa), que conservi aquest acoblament amb el medi.
Per tal de reduir les pertorbacions que provoca el trencament de l'acoblament emergeix la interpretació com l'alternativa per a generar possibilitats d'acció; passar d'un estat present amb trencaments per fer emergir un estat desitjat com a futur viable. En aquesta escletxa que s'obre en l'espai relacional entre l'estat present i l'estat desitjat pren sentit l'ús d'aquestes eines de conversa per a accedir a un rerefons amb mirada compartida. L'estat desitjat acoblat al llenguatge opera com un feed-forward positiu per a la construcció de sentit. S'ajuda a més d'una visió binocular del canvi, analitzant dos series categorials de pensament en la modernitat.
Finalment es descriu l'aplicació i els resultats del Model en una organització de serveis de salut.
Se plantea la fundamentación de un modelo integrado de formación humana, capacitación e intervención organizacional en un contexto pedagógico socio educativo. Explicita un núcleo de inteligibilidad epistemológico, (Gergen, 1996) desarrollando sus contenidos metateoricos, teóricos y metodológico Para situar el modelo en una perspectiva metateórico constructivista y construccionista social, se examinan dos cambios considerados relevantes en las explicaciones epistemológicas de la ciencia que dan sustento a esta perspectiva: el giro lingüístico y el llamado por los biólogos biocibernéticos giro ontológico de la modernidad. Estos fundamentos científicos del constructivismo contenidos en este último, se recogen en el diseño del modelo, que se hace cargo de tres explicaciones que dejan planteadas este giro y de las consecuencias que de ellas surgen para su formalización.-
El diseño del modelo asume estas distinciones y realiza un cruce con los desarrollos post analíticos del giro lingüístico en la comprensión performativa del lenguaje, para la concepción de la organización como una red de conversaciones. Asume el carácter emergente de la conducta lingüística en el acoplamiento con el medio. Este acoplamiento estructural se entiende enactivamente mediante el uso recursivo del lenguaje, para generar compromisos para un aprendizaje que integre las personas al sistema.
El diseño es un Modelo autopoiético que metodológicamente reencuadra la investigación-acción usando herramientas de cibernética de primer orden en una cibernética de segundo orden, mediante conversaciones recurrentes para articular las metas de la organización con el espacio relacional. Incorpora metodologías de primera persona performativas comunicacionales como herramientas para integrar la dimensión valórica del si mismo con las metas de la organización, para reproducirla mediante integración social. Opera mediante trabajo grupal para que las conversaciones se sitúen en la segunda persona, (yo-otros), para posibilitar la emergencia de la primera persona.
Asume la distinción de las dos dimensiones del ser cognitivo (Varela 2000), una de enlace mediante el lenguaje para la coderiva del sistema con el medio, y una dimensión de excedente de significación, esto es, de interpretación para la reformulación de la experiencia en el lenguaje (narrativa), que conserve ese acoplamiento con el medio.
Para reducir las perturbaciones que provocan el quiebre del acoplamiento emerge la interpretación como la alternativa para generar posibilidades de acción, pasar de un estado presente con quiebres para hacer emerger un estado deseado como futuro viable. En esa brecha que se abre en el espacio relacional entre el estado presente y el estado deseado hace sentido el uso de estas herramientas conversacionales para acceder a un trasfondo con mirada compartida. El estado deseado acoplado al lenguaje opera como un feed forward positivo para la construcción de sentido. Se apoya para ello, además, en una visión binocular del cambio, analizando dos series categoriales de pensamiento en la modernidad.
Finalmente se describe la aplicación y resultados del Modelo en una organización de servicios de salud.
The foundation for an integrated model of human formation, training and organizational intervention within a socio-educational pedagogic context is presented here. It explicits an epistemological intelligibility core (Gergen, 1996) developing its theoretical, metatheoretical and methodological contents. To place the model into a metatheoretical social constructivism and social constructionist perspective, two relevant considered shifts in epistemological explanations of science that supports this perspective are reviewed: the linguistic turn and the so called by biocybernetical biologists ontological turn of modernity. These scientific foundations of constructivism contained in this turn, are brought into the model design that takes charge of three explanations put forward by the turn and the consequences arising from them for its formalization.
The design of the model assumes these distinctions and performs a crossing with the post analytical developments of the linguistic turn in the performative comprehension of language, for conceiving the organization as a network of conversations. It assumes the emerging character of linguistic behavior in coupling to the environment. This structural coupling is enactively understood through the recursive use of language, to generate commitments for a learning that integrates persons to the system.
The design is an autopoietical model that methodologically reframes research-action using tools of first order cybernetics within a second order cybernetics, through recurrent conversations to articulate organization's goals with the relational space. It incorporates communicational first person performative methodologies as tools to integrate the valoric dimension of the self with the organization's goals, to reproduce it through social integration. It operates through group work placing conversations in second person (I - others), for making the emergence of the first person possible.
It assumes the distinction of the two dimensions of the cognitive being (Varela, 2000), one as a link of language for the co-derive of the system with the environment and one as signification surplus, that is, of interpretation for the reformulation of the experience in language (narrative), that keep that coupling with the environment.
Interpretation emerges as the alternative for generating action possibilities to reduce perturbations that provoke the breaking of coupling, to go through a present state with breakings to an emergent wished state as a viable future. In this breach opened in the relational space between the present state and the wished state the use of these conversational tools makes sense to access a background with shared vision. The wished state coupled to language operates as a positive feed forward for constructing meaning. It also supports itself on a binocular vision of change, analyzing two categorical series of thought in modernity.
Finally, the application and results of the model are described within a health services organization.
植田, 裕志, i Hiroshi UEDA. "「アーサー王と聖杯 - 二つの散文聖杯物語から - 」". 名古屋大学文学部, 1989. http://hdl.handle.net/2237/9260.
Pełny tekst źródłaOuahid, Hicham. "Data extraction from the Web using XML". Thesis, University of Ottawa (Canada), 2001. http://hdl.handle.net/10393/9260.
Pełny tekst źródłaCulpepper, Martin L. (Martin Luther). "Design and application of compliant quasi-kinematic couplings". Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/9260.
Pełny tekst źródłaIncludes bibliographical references (p. 113-116).
Better precision at lower costs is a major force in design and manufacturing. However, this is becoming increasingly difficult to achieve as the demands of many location applications are surpassing the practical performance limit (~ five microns) of low-cost couplings. The absence of a means to meet these requirement has motivated the development of the Quasi-Kinematic Coupling (QKC). This thesis covers the theoretical and practical considerations needed to model and design QKCs. In a QKC, one component is equipped with three spherical protrusions while the other contains three corresponding conical grooves. Whereas Kinematic Couplings rely on six points of contact, the six arcs of contact between the mated protrusions and grooves of QKCs result in a weakly over-constrained coupling, thus the name Quasi-Kinematic. QKCs are capable of sub-micron repeatability, permit sealing contact as needed in casting, and can be economically mass produced. The design and application of a QKC is demonstrated via a case study on the location of two engine components. Integration of the QKC has improved coupling precision from 5 to 0.7 microns. In addition, this QKC uses 60% fewer precision features, 60% fewer pieces, costs 40% less per engine, and allows feature placement tolerances which are twice as wide as those of the previous dowel-pin-type coupling.
by Martin L. Culpepper.
S.M.
McCants, Michael. "Efficacy of robust regression applied to fractional factorial treatment structures". Thesis, Kansas State University, 2011. http://hdl.handle.net/2097/9260.
Pełny tekst źródłaDepartment of Statistics
James J. Higgins
Completely random and randomized block designs involving n factors at each of two levels are used to screen for the effects of a large number of factors. With such designs it may not be possible either because of costs or because of time to run each treatment combination more than once. In some cases, only a fraction of all the treatments may be run. With a large number of factors and limited observations, even one outlier can adversely affect the results. Robust regression methods are designed to down-weight the adverse affects of outliers. However, to our knowledge practitioners do not routinely apply robust regression methods in the context of fractional replication of 2^n factorial treatment structures. The purpose of this report is examine how robust regression methods perform in this context.
Brisson, Angèle. "Apprentissage de la discrimination visuelle chez les déficients mentaux au moyen d'exercices de stimulation appropriés". Mémoire, Université de Sherbrooke, 1985. http://hdl.handle.net/11143/9260.
Pełny tekst źródłaFelício, Dora de Jesus Murilhas. "Produção Textual: Percursos de Aprendizagem no 1º Ciclo". Master's thesis, Faculdade de Ciências Sociais e Humanas, Universidade Nova de Lisboa ; Escola Superior de Saúde, Instituto Politécnico de Setúbal, 2011. http://hdl.handle.net/10362/9260.
Pełny tekst źródłaA linguagem escrita possui uma dimensão social que a escola, como formadora de futuros cidadãos, não pode ignorar. Mais do que um meio de comunicação, a escrita constitui uma forma de participação social e de criação estética. Face a este contexto, surge a necessidade de implementar nas escolas a cultura de uma pedagogia de escrita, associada a situações de prazer e de reforço da autoconfiança, que passe por um plano de intervenção específico e um treino intencional, sistemático, progressivo e faseado. Para aprender a escrever é preciso escrever e refletir sobre a escrita e as suas finalidades. É preciso entender a escrita como um processo que implica reflexão e conhecimento sobre as suas componentes: planificação, textualização e revisão. Este trabalho teve como objetivo investigar em que medida o ensino da escrita contribui para o desenvolvimento e aperfeiçoamento da produção textual dos alunos e centra-se na discussão de como as práticas em sala de aula e a atitude do professor de língua portuguesa são basilares neste processo.
Nuñgulu, Agostinho Tchivange Nandjunge. "Monitorização das espécies de brocas do milho em Angola. Gestão das suas populações com recurso a plantas-isco e plantas repelentes". Doctoral thesis, ISA/UL, 2014. http://hdl.handle.net/10400.5/9260.
Pełny tekst źródłaStem borers (Insecta: Lepidoptera) in Africa emerge as a major biotic constraints to cereal production. The distribution of species depends on the region and the losses tend to be higher in altitude. For the monitoring of species of stem borers in Angola were used sex pheromone traps for Busseola fusca, Chilo partellus and Sesamia calamistis that were installed in Cavaco, Alto Kapaka, Cela, Chianga and Humpata. To study the management of populations of stem borers using the push-pull system were held in Huambo tests, using as attractive plant Pennisetum purpureum and as repellent plant Desmodium uncinatum. It was found that the three species monitored were present at all sites sampled B. fusca was the dominant species in Chianga, Cela and Alto Kapaka and S. calamistis in Cela and Cavaco. In capturing the pheromone B. fusca ‘Pherobank’ was significantly more effective than pheromone ‘Insect Science’. The incidence of attacks of borers in maize ranged between 86.2% in the control and 14.4% in the treatment maize x P. purpureum x D. uncinatum. For the four years of trials the average production increase in treatment that used attractive and repulsive plants was 340.6%, compared to maize alone
Jones, Cameron Bennion. "Development and Validation of a Vibration-Based Sound Power Measurement Method". BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/9260.
Pełny tekst źródłaSantamaría, Jotty Luz Emilia. "Influencias del uso de las tecnologías de la información y la comunicación en el aprendizaje de los estudiantes de Historia y Geografía de la Universidad Nacional Mayor de San Marcos". Master's thesis, Universidad Nacional Mayor de San Marcos, 2015. https://hdl.handle.net/20.500.12672/9260.
Pełny tekst źródłaAborda la influencia del uso de las tecnologías de la información y la comunicación (TIC) en el aprendizaje universitario de los estudiantes de las escuelas de Historia y Geografía de la Facultad de Ciencias Sociales de la Universidad Nacional Mayor de San Marcos. El desarrollo de la investigación se llevó a cabo en el segundo semestre académico del 2012 y en donde se aplicó un muestreo mixto que consistió en encuestas (cuantitativo) y en entrevistas estructuradas (cualitativa). Según algunos resultados obtenidos, la mayoría de los alumnos son del sexo masculino y se encuentran entre las edades de 20 a 22 años, todos ellos emplean las TIC en sus vidas diarias, al igual que en el desarrollo de sus actividades académicas, por lo tanto, es una herramienta de uso en el aprendizaje.
Tesis
Raubenheimer, Jacobus Hendrik. "Geographic information system as a map and survey database for a selected area". Master's thesis, University of Cape Town, 1996. http://hdl.handle.net/11427/9260.
Pełny tekst źródłaThe purpose of this research was to identify how the distribution and availability of spatial data could be improved. This should then minimize the duplication of data and ensure a better utilization of available data sources. All decisions that are made should be based on information, and especially decisions about our natural resources should be based on geographical information - this is spatial information of our environment. Many users, however, are not aware of the spatial data available or where to find it. In Chapter 2 the literature review reports on the spatial data sources in other countries, and different methods that are used to make this data available to the users. Most of the research was done on the distribution of digital data, and not much on traditional non-digital material. The establishment of national land information systems and data sharing via the networking of databases is receiving wide attention. An investigation was done to establish the spatial data suppliers and the data users, the types of data supplied, and the requirements. Three possible methods were investigated to improve the distribution of spatial data and•to reduce the duplication of data: a comprehensive GIS with a full database; a national spatial data infrastructure (NSDI); a metadata base.
Fox, Brian Andrew. "Structural studies of factor XIII /". Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/9260.
Pełny tekst źródłaDolor, Marvourneen Kimranee. "Investigation of Rhenium's biogeochemistry". College Park, Md. : University of Maryland, 2009. http://hdl.handle.net/1903/9260.
Pełny tekst źródłaThesis research directed by: Chemistry. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
Gribble, Samuel James. "'Harry the Ninth (The Uncrowned King of Scotland) Henry Dundas and the Politics of Self-Interest, 1790-1802". Thesis, Department of History, 2012. http://hdl.handle.net/2123/9260.
Pełny tekst źródłaKostyrko, Diana J. "Journal of an homme d'affaires, Rene Gimpel 1918-1939: anatomy of cultural perception". Phd thesis, Canberra, ACT : The Australian National University, 2006. http://hdl.handle.net/1885/9260.
Pełny tekst źródłaTrevisan, Mauro <1989>. "Preparazione e reattività di "half-sandwich" carbeni complessi stabilizzati da leganti bipiridilici". Master's Degree Thesis, Università Ca' Foscari Venezia, 2016. http://hdl.handle.net/10579/9260.
Pełny tekst źródłaMartins, Cintya de Azambuja. "Comparação dos fluxos turbulentos em diferentes condições de estabilidade e topografia". Universidade Federal de Santa Maria, 2004. http://repositorio.ufsm.br/handle/1/9260.
Pełny tekst źródłaIn this study sensible and latent heat fluxes as well as momentum flux were analysed in terms of similarity parameters. The intensity of the turbulence and the correlation functions are also studied. The data used in this work were collected in three differents sites and in differents seasons of the year. The topography of the sites are representatives of heterogeneous and non- heterogeneous conditions. In all sites micrometeorological towers instrumented with fast response sensors colleted data with a rate of 10 Hz. In order to analysis of the data a computacional program for the S-Plus software was developed. Results indicates that for very complex topography only the non- dimensinal standard deviation of humidity at stable conditions follow the Monin- Obukhov Similarity Theory. Under near homogeneous conditions all parameters presented in this study have a acceptable description in terms of similarity theory, except the correlation coeficient for the momentum flux.
Neste estudo os fluxos turbulentos de calor sensível, calor latente e momentum, parâmetros de intensidade da turbulência, são investigados em diferentes condições de estabilidade e topografia com o objetivo de verificar a validade da Teoria de Similaridade de Monin- Obukhov (TSMO). Os dados aqui analisados foram obtidos em experimentos micrometeorológicos nos sítios de Paraíso do Sul e Santarém, que caracterizam topografias quase homogêneas, e no sítio de Nova Roma do Sul que caracteriza terreno complexo. Os sítios de Nova Roma do Sul e Paraíso do Sul, localizam-se no estado do Rio Grande do Sul e o sítio de Santarém, no estado do Pará. Nestes três sítios torres micrometeorológicas equipadas com sensores de resposta rápida fornecem dados de velocidade do vento, temperatura e umidade do ar a uma freqüência de 10 Hz. Os resultados indicaram que em Nova Roma do Sul os parâmetros de intensidade da turbulência mecânica e térmica não seguem a TSMO, enquanto que apenas o desvio padrão de umidade, normalizado pela escala de umidade da camada superficial, somente em regime estável é parametrizado segundo a TSMO. Nos demais sítios estas funções adimensionais são adequadamente descritas em termos do parâmetro de estabilidade de Monin- Obukhov ( z L). Em Nova Roma do Sul, cuja superfície é heterogênea, os fluxos de calor sensível e latente, normalizados pelos desvios padrões das respectivas grandezas, não seguem a TSMO e somente o fluxo de momentum, normalizado pelos desvios padrões das velocidades horizontal e vertical, a TSMO é válida nos três regimes de estabilidade. Nos sítios com superfícies homogêneas os coeficientes de correlação dos fluxos turbulentos de calor sensível, latente e momentum são parametrizadas de acordo com a TSMO, enquanto que em Santarém, somente para o coeficiente de correlação do fluxo de momentum, o comportamento não pôde ser estimado com z L , ao contrário dos coeficientes de correlação do fluxo de calor latente e sensível.
Ransom, Miriam Anna 1972. "Representing sexualised otherness : Asian woman as sign in the discourse of the Australian press". Monash University, School of Literary, Visual and Performance Studies, 2001. http://arrow.monash.edu.au/hdl/1959.1/9260.
Pełny tekst źródłaNkoi, Barinyima. "Techno-economic studies of environmentally friendly Brayton cycles in the petrochemical industry". Thesis, Cranfield University, 2014. http://dspace.lib.cranfield.ac.uk/handle/1826/9260.
Pełny tekst źródłaSilva, Abraão Balbino e. "Remuneração das Redes de Telefonia Móvel no Brasil". reponame:Repositório Institucional da UnB, 2011. http://repositorio.unb.br/handle/10482/9260.
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O propósito da presente dissertação é fazer uma análise da questão da interconexão de redes detelefonia móvel no Brasil, levando em consideração os aspectos regulatórios existentes, previsõesregulamentares da Agência Nacional de Telecomunicações – Anatel e os aspectos econômicosenvolvidos. Como referência teórica são utilizados os modelos propostos por Armstrong & Wright(2008), a partir dos quais são desenvolvidos modelos para o caso brasileiro. Após o desenvolvimentodos modelos, utiliza-se o modelo com probabilidade de expansão do mercado para a realização desimulações com vistas à avaliação de impactos de medidas regulatórias em relação a alterações noValor de Uso de Rede Móvel – VUM. _______________________________________________________________________________ ABSTRACT
The purpose of this dissertation is to analyze the issue of interconnection of mobile networks in Brazil,taking into account the existing regulatory issues, forecasts regulations of the NationalTelecommunications Agency - Anatel and the economics involved. We use as theoretical referencethe models proposed by Armstrong & Wright (2008), from which models are developed for theBrazilian case. After developing the models, we use the model with probability of market expansion forthe simulations regarding the impacts of regulatory measures in relation to changes in the value ofMobile Termination Rates - MTR.