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1

Bhogal, Talvinder, Ethan Sokol, Shakti Ramkissoon, Athina Giannoudis, Kimberly McGregor, Allison Clark, Evangelia Razis, Rupert Bartsch, Richard Huang i Carlo Palmieri. "Abstract P5-07-04: Comprehensive analysis of the gene rearrangements within 822 breast cancer brain metastases reveals an enrichment of cyclin dependent kinase 12 rearrangements in HER2-positive brain metastases". Cancer Research 82, nr 4_Supplement (15.02.2022): P5–07–04—P5–07–04. http://dx.doi.org/10.1158/1538-7445.sabcs21-p5-07-04.

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Abstract Introduction:. Breast cancer (BC) brain metastases (BM) are a growing clinical problem as survival for metastatic BC improves. Genomic analyses of BM are key to developing more targeted therapeutic interventions. In this study we explored the gene rearrangements of BM and compared these to a cohort of non-paired local breast cancers (BCs) and non-CNS metastasis (N-CNS). Methods:. We analyzed 822 BMs and compared them to 11,988 local, breast-biopsied BCs and 15,516 N-CNS (samples unpaired) profiled with comprehensive genomic profiling (CGP) (Foundation Medicine, Cambridge, MA, USA) examining all classes of alterations in at least 324 genes. The prevalence of individual gene rearrangements within the BM was compared to those within BC and N-CNS cases. Further analysis was undertaken by classifying BM, BC and N-CNS specimens with respect to their oestrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) status, available for a subset of samples. Results:. CGP identified 307 rearrangement events in BMs impacting 169 genes. Twenty genes exhibited recurrent rearrangement events with a prevalence greater than 0.5% in either the BM, BC or N-CNS. 10 of these 20 genes were significantly more prevalent within the BM specimens vs. BC and N-CNS (p<0.05). The 10 significant genes and their prevalence in BM were as follows: CDK12 (3.53%, 29/822), RB1 (1.95%, 16/822), ETV6 (1.70%, 14/822), FANCA (0.73%, 6/822), PALB2 (0.73%, 6/822), ATR (0.61%, 5/822), CTNNA1 (0.61%, 5/822), FBXW7 (0.61%, 5/822), KDM5C (0.61%, 5/822) and MSH6 (0.61%, 5/822). BMs were enriched with CDK12 rearrangements (3.53%, 29/822) as compared to the BC (0.86%, 103/11,988; p=4x10-9) and N-CNS specimens (0.68%, 105/15,516; p=2x10-11). CDK12 rearrangements had a significantly higher propensity within HER2+ BM (14.59%, 27/185) as compared to the HER2+ BC (7.80%, 86/1,102; p=0.0046) and HER2+ N-CNS (7.87%, 94/1,194; p=0.0048). Further analysis by receptor status is outlined in Table 1. Conclusion:. These data demonstrate that overall rearrangements are uncommon in BMs. However, we identified that the most common rearrangement involves CDK12 which has a relatively high prevalence in HER2+ BMs compared to HER2+ primary BCs and N-CNS. These data support more detailed investigation of the role and importance of CDK12 rearrangements in BM secondary to breast cancer. The prevalence of CDK12 rearrangements within BM, BCs, and other N-CNS in different sub-types of BC.SubtypePrevalenceP-valueBM BCN-CNSBM vs. BCBM vs. . N-CNSAll3.53%. (29/822)0.86%. (103/11,988)0.68%. (105/15,516)3.55x10-91.85x10-11HER2+(irrespective of ER status)14.59%. (27/185)7.80%. (86/1,102)7.87%. (94/1,194)0.00460.0048HER2+, ER-15.29%. (13/85)10.53%. (6/57)1.96%. (1/51)0.460.02HER2+, ER+13.64%. (9/66)7.14%. (6/84)10.20%. (5/49)0.270.77HER2-, ER-0.67%. (2/298)0.17%. (1/585)0.69%. (2/291)0.261.00HER2-, ER+0.00%. (0/212)0.16%. (1/641)0.00%. (0/634)1.001.00 Citation Format: Talvinder Bhogal, Ethan Sokol, Shakti Ramkissoon, Athina Giannoudis, Kimberly McGregor, Allison Clark, Evangelia Razis, Rupert Bartsch, Richard Huang, Carlo Palmieri. Comprehensive analysis of the gene rearrangements within 822 breast cancer brain metastases reveals an enrichment of cyclin dependent kinase 12 rearrangements in HER2-positive brain metastases [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P5-07-04.
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Litwin, Tomasz, Jan Bembenek, Agnieszka Antos, Iwona Kurkowska-Jastrzębska, Adam Przybyłkowski, Marta Skowrońska, Łukasz Smoliński i Anna Członkowska. "The Maternal and Fetal Outcomes of Pregnancy in Wilson’s Disease: A Systematic Literature Review and Meta-Analysis". Biomedicines 10, nr 9 (24.08.2022): 2072. http://dx.doi.org/10.3390/biomedicines10092072.

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Wilson’s disease (WD) is a rare, treatable genetic disorder with multi-organ symptoms related mainly to copper accumulation. Most patients become aware of the disease as young adults, thus knowledge on fertility, pregnancy course and outcome is very important both for patients and physicians. The aim of this study was to perform a systematic review and meta-analysis of pregnancy outcomes in women with WD. This systematic literature review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies were identified by searching the PubMed database (up to 12 January 2022) and by screening reference lists. We found 49 publications, including 13 retrospective studies and 36 series and case reports on pregnancy outcomes in WD patients. In total, descriptions of 449 pregnant women with 822 pregnancies were retrieved. Successful deliveries were achieved in 78.3% (644/822) of all pregnancies. Spontaneous abortions were observed in 21.7% (178/822) of pregnancies, more frequently in patients who were untreated 68.6% (96/140). Analyzing maternal outcome, 2.2% (18/822) of pregnancies were associated with the aggravation of neurological symptoms. Symptoms of hepatic deterioration were observed in 4.6% (38/822) of cases. These were usually transient and recovered after pregnancy; however, death due to liver failure was observed in 0.2% (2/822) of cases. Birth defects occurred in 4.7% (39/822) of pregnancies. The available meta-analysis showed statistically significant positive associations between anti-copper treatment and pregnancy outcome. Our results document the significance of anti-copper treatment as the main factor leading to successful pregnancy, as well as positive outcomes for women with WD.
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B. GANGAIAH. "Response of oat (Avena sativa) varieties to irrigation schedules". Indian Journal of Agronomy 50, nr 2 (10.10.2001): 165–66. http://dx.doi.org/10.59797/ija.v50i2.5094.

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A field experiment was conducted during winter season (1 998-99 and 1999-2000) to assess the effect of 4 ir- rigation schedules based on irrigation water : cumulative pan evaporation (IW : CPE) ratios on performance 2 oat varieties ('JHO 822' and 'JHO 851') revealed that the varieties did not differ for fodder yield and N concentration. However, based on crude protein yield (qlha) 'JHO 851' (6.08) was found significantly superior to 'JHO 822' (5.29), whereas in respect of water-use efficiency (kg dmlha-mm) 'JHO 822' (28.6) was superior to 'JHO 851' (20.3). Among the 4 irrigation schedules, fodder yield and water-use efficiency increased significantly with increasing IW: CPE ratio from 0.0 to 0.9 ratio.
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Balasubramaniam, Madhura. "Book review: Farhana Ibrahim and Tanuja Kothiyal (eds.), South Asian Borderlands: Mobility, History, Affect". India Quarterly: A Journal of International Affairs 79, nr 1 (marzec 2023): 128–31. http://dx.doi.org/10.1177/09749284221146525.

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Müller, Carl-Jochen, i Jürgen Klöckler. "Rezension von: Klöckler, Jürgen, Selbstbehauptung durch Selbstgleichschaltung". Zeitschrift für Württembergische Landesgeschichte 72 (8.04.2022): 652–53. http://dx.doi.org/10.53458/zwlg.v72i.2473.

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Jürgen Klöckler: Selbstbehauptung durch Selbstgleichschaltung. Die Konstanzer Stadtverwaltung im Nationalsozialismus (Konstanzer Geschichts- und Rechtsquellen XLIII). Ostfildern: Thorbecke 2012. XLIX und 822 S. ISBN 978-3-7995-6843-2. € 39,–
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Narangari, Parvathala Reddy, Siva Krishna Karuturi, Yiliang Wu, Jennifer Wong-Leung, Kaushal Vora, Mykhaylo Lysevych, Yimao Wan, Hark Hoe Tan, Chennupati Jagadish i Sudha Mokkapati. "Ultrathin Ta2O5 electron-selective contacts for high efficiency InP solar cells". Nanoscale 11, nr 15 (2019): 7497–505. http://dx.doi.org/10.1039/c8nr09932d.

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This work demonstrates stoichiometric Ta2O5 ultrathin layer as a novel and efficient electron-selective contact for planar InP heterojunction solar cells achieving an efficiency of 19.1% and a highest ever reported open circuit voltage of 822 mV.
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Buriev, Khasan, i Kurbonalijon Zokirov. "Seasonal and daily blooming rhythm of cucumber (Cucumis sativus) belonging to Cucurbitaceae family". E3S Web of Conferences 452 (2023): 01015. http://dx.doi.org/10.1051/e3sconf/202345201015.

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The blooming period of the cucumber plant depended on the characteristics of the varieties, meteorological conditions, the time of planting, and the order of harvesting the fruits. Generative organs appeared in the leaf axils on the 15th-18th day after germination in the “Uzbeksky 740” variety, and on the 18th-22nd day in the “Margelansky 822” variety. After some time, it was possible to determine the gender of the flower. Male flowers bloomed first: 35-40 days after germination in “Uzbeksky 740” variety, 50-55 days in “Margelansky 822” variety. Blooming of female flowers is observed after 42-47 days after germination in “Uzbeksky 740” variety and after 57-62 days in “Margelansky 822” variety. In the Tashkent region, the blooming of female flowers in the “Uzbeksky 740” variety coincided with the 40th day from the day of emergence of sprouts at the optimal density between plants. This was 45% of the period from germination to fruit ripening. When the plant thickened to 142,800/ha, the blooming of female flowers was delayed by 2 days, fruit formation by 8 days, and fruit ripening by 22 days. This was found that the period of branching - blooming occupied 38% of the period of branching - fruit ripening.
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Żukowski, Antoni. "Pojęcie niebudzącego wątpliwości dowodu na piśmie – uwagi na gruncie art. 822 k.p.c. oraz art. 845 § 2(2) k.p.c." Przegląd Prawa Egzekucyjnego 2023, nr 2 (24.02.2023): 50–74. http://dx.doi.org/10.62627/ppe.2023.007.

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This article discusses a term that appears in the Civil Procedure Code solely in the part concerning enforcement proceedings. The legislator only uses the term specified in the title above in two articles: Art. 822 of the Civil Procedure Code and Art. 845 § 2(2) of the Civil Procedure Code. The term “unambiguous written proof” has not been subject to the doctrine or the judicature’s statement, yet. While, the fact that enforcement authorities identify, in specific actual circumstances, “an unambiguous written proof” is essential for the parties of the proceedings and that is why this issue has been analysed in detail in this paper.
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OHTA, Makoto, i Daniel A. RUFENACHT. "822 Three Dimensional Geometry Measurements of Cerebral Aneurysms and Vessel Sizes for Analytical Geometry(2)". Proceedings of the Fluids engineering conference 2006 (2006): _822–1_—_822–4_. http://dx.doi.org/10.1299/jsmefed.2006._822-1_.

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Litwinow, Jerzy. "Polskie i portugalskie regulacje dotyczące obowiązkowego raportowania krajowych schematów podatkowych (MDR) – analiza porównawcza wybranych zagadnień". Doradztwo Podatkowe - Biuletyn Instytutu Studiów Podatkowych 1, nr 317 (31.01.2023): 14–26. http://dx.doi.org/10.5604/01.3001.0016.2311.

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Celem niniejszego artykułu jest dokonanie syntetycznej analizy prawnoporównawczej wybranych aspektów obowiązkowegoraportowania krajowych schematów podatkowych w Polsce i Portugalii w związku z implementacją dyrektywyRady (UE) 2018/822 z dnia 25 maja 2018 r. zmieniającej dyrektywę 2011/16/UE w zakresie obowiązkowej automatycznejwymiany informacji w dziedzinie opodatkowania w odniesieniu do podlegających zgłoszeniu uzgodnień transgranicznych1(tzw. dyrektywy DAC-6). Uzasadnieniem takiego porównania jest objęciem obowiązkiem raportowania – pozaschematami transgranicznymi – również schematów krajowych, co nie występuje w pozostałych krajach Unii Europejskiej(UE)2. Regulacje polskie – mimo wprowadzenia kryterium kwalifikowanego korzystającego – powodują w praktycekonieczność o wiele częstszego raportowania niż regulacje portugalskie, które nie mają takiego ograniczenia.Zwrócono szczególną uwagę na problem zawężenia zakresu tajemnicy zawodowej adwokatów, które w przypadkuPortugalii jest o wiele bardziej ingerujące w ten zawód zaufania publicznego. W tym opracowaniu zastosowano metodęformalno-dogmatyczną i prawno-porównawczą do analizy przepisów dyrektywy, ustaw oraz pozostałych aktówprawnych. Zweryfikowano, które przepisy są efektywniejsze pod kątem celów wyznaczonych w dyrektywie 2018/822oraz które wprowadzają mniejsze ograniczenia tajemnicy zawodowej. Uwzględniono również cele polskiego ustawodawcywprowadzającego obowiązki w zakresie MDR3, w tym jego uzasadnienie konieczności istnienia takich obowiązków,nawet gdyby nie było dyrektywy 2018/822. Należy rozważyć de lege ferenda podwyższenie kary dla osób, którekierują dużymi podmiotami w Portugalii (np. będącymi częścią międzynarodowych spółek kapitałowych), a które nieraportują schematów podatkowych, oraz obniżenie kar dla pozostałych podmiotów w Polsce.
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Yagan, J., T. Mahmoud, O. Geith, N. El Serwey, M. Mustafa, S. Reda, P. Nair i T. AlOtaibi. "POS-822 SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITORS (SGLT2i); SHORT-TERM OUTCOME IN DIABETIC KIDNEY TRANSPLANT RECIPIENTS". Kidney International Reports 7, nr 2 (luty 2022): S354. http://dx.doi.org/10.1016/j.ekir.2022.01.858.

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Zhang, Shuo, Eiji Sakuradani, Kuni Ito i Sakayu Shimizu. "Identification of a novel bifunctional Δ12/Δ15 fatty acid desaturase from a basidiomycete,Coprinus cinereusTD#822-2". FEBS Letters 581, nr 2 (2.01.2007): 315–19. http://dx.doi.org/10.1016/j.febslet.2006.12.031.

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Koga, Toshikatsu, Hidenori Aoki i Ajit J. Thakkar. "Kinetic energy analysis of atomic multiplets. II. smdn configurations". Canadian Journal of Chemistry 74, nr 6 (1.06.1996): 775–80. http://dx.doi.org/10.1139/v96-085.

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A kinetic energy analysis of total energy differences in 822 atomic multiplets arising from smdn (m = 0,1,2; n = 2–8) electronic configurations is performed within the nonrelativistic, restricted Hartree–Fock framework. For the 444 multiplets arising from the dn and s2dn configurations of 27 atoms in groups 2–10, a very good linear correlation between the total energy difference and the kinetic energy difference of the outermost d-electrons is demonstrated. For the 378 multiplets arising from the sdn configuration, on the other hand, a good linear correlation is obtained provided that the multiplets are classified into groups based on spin multiplicity. Key words: kinetic energy, atomic multiplets, smdn configurations, Hartree–Fock approximation.
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Pastwa, Andrzej. "The Digital Environment as a Space of the Evangelization Activity: New Dimension of the Obligations Arising from the Prescripts of can. 822 CIC". Philosophy and Canon Law 9, nr 2 (29.12.2023): 1–25. http://dx.doi.org/10.31261/pacl.2023.09.2.02.

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Contemporary papal enunciations are characterized by the assertive―active and optimistic, yet risk-conscious and non-critical―ecclesial approach to the opportunities/challenges of the “digital age.” If we follow these indications, imbued with the concern for the effectiveness of the evangelizing mission in the new socio-(technological-)cultural realities/contexts, and at the same time bear in mind the rule that the Church’s legal practice must take into account the current conditions of human existence—it becomes clear that this authoritatively outlined horizon of the “signs of the times” poses a challenge to theological sciences, including the canonical doctrine. As far as the latter is concerned, leaving aside the often urgent need for legislative changes/adjustments (given the peculiarities of the various regions of the world—above all at the level of particular law), the role of experts in presenting a renewed, adequate hic et nunc interpretation of certain nodal canons of the Code of Canon Law remains invaluable. We may argue that such include the prescripts of can. 822. Hence, this article attempts a two-stage delimitation of the problem meritum—according to the research steps announced in the title: (1) The digital environment as an indispensable space of the evangelization activity; (2) The new dimension of the obligations of the Church’s Pastors imposed by the prescripts of can. 822 §§ 1–3.
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ELLIOTT, CLARE. "Jay Grossman, Reconstituting the American Renaissance: Emerson, Whitman, and the Politics of Representation (Durham: Duke University Press, 2003, £50 cloth, £15.95 paper). Pp. 280. ISBN 0 822 33129 2, 0 822 33116 0." Journal of American Studies 38, nr 3 (grudzień 2004): 509–10. http://dx.doi.org/10.1017/s0021875804318773.

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Goodman, Jim. "Nucleon". JOURNAL OF ADVANCES IN PHYSICS 13, nr 3 (29.03.2017): 4726–30. http://dx.doi.org/10.24297/jap.v13i3.5937.

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The force here is the nuclear force binding the nuclei together. A magnetic dipole has the energy given by -13.6*2*n^2[3]. A particle with n=822 is a magnetic dipole with magnetic quantum number m=1,2,3,… so that -18.3786Mev*m is an energy/mass which we may associate with the nucleus. The relativistic correction 2[4] is required showing that the dipole velocity is near c. The nuclei are bound with particles of mass 18Mev consisting of 6 magnetic dipoles each. The binding energy tracks very well with Z-1 particles where Z is the atomic number of the element. The particle is named a Nucleon after the manner of graviton and should not be confused with the common name for a nuclear particle (proton or neutron).
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Balaubaeva, B., i A. Karimsakov. "Some issues of Chinese migration in Southeast Asia". KazNU BULLETIN. International relations and international law series Vol 78, nr 2 (2017): 35–42. http://dx.doi.org/10.26577/irily-2017-2-822.

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Sutuyeva, L. R., T. M. Shalakhmetova, V. L. Trudeau, S. Zh Kolumbayeva i A. V. Lovinskaya. "Growth and development of the green toad (Bufo viridis) from the water bodies of the oil producing regions of Kazakhstan". Eurasian Journal of Ecology 2, nr 55 (2018): 111–20. http://dx.doi.org/10.26577/eje-2018-2-822.

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Buriev, Khasan. "Growth dynamics of the fruit of members of the Cucurbitaceae family". E3S Web of Conferences 452 (2023): 01020. http://dx.doi.org/10.1051/e3sconf/202345201020.

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In this article, the results of the research conducted to study the growth dynamics of the fruits of plants belonging to the Cucurbitaceae family, the fruit growth took place along a simple sigmoid curve: at first, the size and weight of the fruit increased exponentially, then this process slowed down, and it was given with an in-depth scientific analysis. It was noted that the ratio of fruit formation and ripening periods was 1:2 in "Uzbeksky 740" and "Margelansky 822" varieties of cucumber, and that the period of fruit formation in "Uzbeksky 452" and "Kuzybay 30" watermelon varieties was slightly longer than its ripening period.
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Seong, J. "The outcome of definitive or salvage radiotherapy for locally advanced hepatocellular carcinoma: A retrospective cohort study of 822 patients from a single institution." Journal of Clinical Oncology 29, nr 4_suppl (1.02.2011): 248. http://dx.doi.org/10.1200/jco.2011.29.4_suppl.248.

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248 Background: With technological development and awareness of efficacy, radiotherapy (RT) is more frequently adopted in management of hepatocellular carcinoma (HCC). To assess the efficacy of RT, we conducted this retrospective cohort study from a single institute. Methods: The analysis involved 822 patients who underwent definitive or salvage RT for locally advanced HCC from January 1997 to August 2009. Two-dimensional RT, 3-dimensional conformal RT (3D-CRT), and intensity-modulated RT including tomotherapy (IMRT) were carried out for 186 (22.6%), 579 (70.4%), and 57 (6.9%) patients, respectively. In a majority of patients, RT was done either concurrently with intra-arterial 5-FU (500 mg/m2) chemotherapy (CCRT group; 326 patients, 39.7%), or following transarterial chemoembolization (TACE+RT group; 244 patients, 29.7%). Total radiation dose was 30 to 64.8 Gy (median dose 45 Gy) in 1.8-2 Gy fraction. Results: The median age of total 822 patients was 55 and 84.3% was male. The 2, 3, and 4-year overall survival rates of total patients were 21.2, 13.1, and 10.1%, respectively. In 2-year survival, the patients with Child-Pugh class A did better than B or C (23% vs 10.9%, p<0.001), without portal vein thrombosis (PVT) did better than with PVT (26.8% vs 14.3%, p<0.001), and without lymph node metastasis (LNM) did better than with LNM (22.9% vs 11.7%, p<0.001). Patients with total dose higher than 45 Gy did better than those with less than 45 Gy (30.1% vs. 15.6%, p<0.001). The best outcome was shown in patients received higher than 45 Gy using 3D-CRT or IMRT, with 2-year overall survival rates of 25.9% (CCRT) and 41.3% (TACE+RT). Conclusions: This study showed a substantial effect of RT in locally advanced HCC. Further analysis will be continued to provide the best option of radiotherapy for locally advanced HCC. No significant financial relationships to disclose.
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O'Hara, Matthew D. "Sergio Serulnikov, Subverting Colonial Authority: Challenges to Spanish Rule in the Eighteenth-Century Southern Andes. Durham, NC: Duke University Press, 2003. viii + 287 pp. ISBN: 0-822-33110-1 (hbk.); 0-822-33146-2 (pbk.)." Itinerario 29, nr 2 (lipiec 2005): 145–47. http://dx.doi.org/10.1017/s0165115300023901.

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Johnson, K. L. "On the pressure projection in elastohydrodynamic lubrication problems, Parts 1 and 2. Takoao Sawada, IJMS 2005; 47: 822–48". International Journal of Mechanical Sciences 49, nr 6 (czerwiec 2007): 790. http://dx.doi.org/10.1016/j.ijmecsci.2006.11.014.

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Nugraha, Jasin Arrasyid, Karyono, Oman Abdurahman, Adang Saputra, Lano Adhitya, Mochamad Nur Hadi i Wanda Adinugraha. "KARAKTERISTIK ALTERASI BAWAH PERMUKAAN PADA SUMUR CKK-1A KEDALAMAN 250-822 METER WILAYAH KERJA PANAS BUMI DAERAH X, KABUPATEN SUKABUMI, JAWA BARAT". JURNAL GEOMINERBA (JURNAL GEOLOGI, MINERAL DAN BATUBARA) 7, nr 2 (30.12.2022): 188–200. http://dx.doi.org/10.58522/ppsdm22.v7i2.112.

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Penelitian ini dilakukan pada sumur eksplorasi panas bumi CKK-1A dari kedalaman 250 – 822 meter yang terletak di wilayah kerja panas bumi daerah X, Kabupaten Sukabumi, Jawa Barat. Penelitian ini bertujuan untuk mengetahui jenis litologi, jenis mineral alterasi, zona mineral alterasi, tipe alterasi, temperatur, jenis fluida, dan mengkorelasikan antara temperatur terukur (logging temperatur dan drilling mud temperatur) dengan temperatur mineral alterasi (geotermometer). Pengamatan secara megaskopis dilakukan menggunakan bantuan loupe dengan perbesaran 20x dan analisis mikroskopis dan analisis XRD (X-Ray diffraction) di laboratorium PSDMBP. Terdapat 5 jenis variasi litologi pada sumur penelitian yaitu, breksi tuf terubah, breksi andesit terubah, andsit terubah, tuf terubah, dan breksi vulkanik terubah. Dari hasil analisis mikroskopis dan analisis XRD, terdapat beberapa jenis mineral alterasi berupa klorit, zeolit, karbonat, kuarsa sekunder, tridimit, albit, clay, oxide, dan pirit. Berdasarkan kumpulan mineral alterasi yang hadir, terdapat 2 zona mineral alterasi yaitu: 1) Zona Klorit – Zeolit dari kedalaman 250 – 732,40 meter, 742,25 – 803,60, dan 805,25 – 822 meter; dan 2) Zona Mineral Lempung dari kedalaman 732,40 – 742,25 meter dan 803,60 – 805,25 meter. Zona Klorit – Zeolit diinterpretasikan sebagai Tipe Alterasi Sub Propilitik dengan kisaran temperatur >200°C dan terbentuk pada fluida netral, kemudian Zona Mineral Lempung diinterpretasikan sebagai Tipe Alterasi Argilik dengan kisaran temperatur <180°C dan terbentuk pada Fluida asam mendekati netral. Adapun korelasi antara temperatur terukur (logging temperatur dan drilling mud temperatur) dengan temperatur mineral alterasi hidrotermal (geotermometer mineral) menunjukan adanya ketidakselarasan antara kehadiran mineral temperatur tinggi >200°C, dengan nilai temperatur terukur yang hanya berkisaran 10°C – 58°C. Serta tidak adanya peningkatan panas yang hadir pada Mud Temperatur Out. Diinterpretasikan bahwa mineral penciri temperatur tinggi tersebut telah mendingin dan menjadi fosil. Hal tersebut juga terlihat dari hadirnya mineral lempung temperatur rendah (monmorilonit) di dalam zona klorit - zeolit yang bertemperatur tinggi.
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24

Liu, Ning, Sandan Wang, Jinpeng Yuan, Lirong Wang, Liantuan Xiao i Suotang Jia. "Investigation of 6S 1/2–8S 1/2 two-photon transition of cesium atoms by a single 822 nm laser". Laser Physics Letters 19, nr 2 (16.12.2021): 025201. http://dx.doi.org/10.1088/1612-202x/ac3b43.

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Abstract We experimentally investigate the 6S 1/2–8S 1/2 two-photon transition in cesium vapor by a single laser. A blue (455.5 and 459.3 nm) fluorescence signal is observed as a result of 822.5 nm laser beams illuminating the Cs vapor with a counter-propagating configuration. The dependences of the fluorescence intensity on the polarization combinations of the laser beams, laser power and vapor temperature are studied to obtain optimal experimental parameters. The frequency difference between the two hyperfine components of 4158 (7) MHz is measured with a Fabry–Perot interferometer as a frequency reference. Such a large spectral isolation and the insensitivity to the Earth’s magnetic field enable the 6S 1/2–8S 1/2 transition to be a stable frequency standard candidate for a frequency-doubled 1644 nm laser in the U-band window for quantum telecommunication.
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25

Guilherme, João Paulo L. F., Ekaterina A. Semenova, Oleg V. Borisov, Andrey K. Larin, Ethan Moreland, Edward V. Generozov i Ildus I. Ahmetov. "Genomic predictors of testosterone levels are associated with muscle fiber size and strength". European Journal of Applied Physiology 122, nr 2 (18.11.2021): 415–23. http://dx.doi.org/10.1007/s00421-021-04851-w.

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Abstract Purpose Circulating testosterone levels are a heritable trait with anabolic properties in various tissues, including skeletal muscle. So far, hundreds of single nucleotide polymorphisms (SNPs) associated with testosterone levels have been identified in nonathletic populations. The aim of the present study was to test the association of 822 testosterone-increasing SNPs with muscle-related traits (muscle fiber size, fat-free mass and handgrip strength) and to validate the identified SNPs in independent cohorts of strength and power athletes. Methods One hundred and forty-eight physically active individuals (47 females, 101 males) were assessed for cross-sectional area (CSA) of fast-twitch muscle fibers. Significant SNPs were further assessed for fat-free mass and handgrip strength in > 354,000 participants from the UK Biobank cohort. The validation cohorts included Russian elite athletes. Results From an initial panel of 822 SNPs, we identified five testosterone-increasing alleles (DOCK3 rs77031559 G, ESR1 rs190930099 G, GLIS3 rs34706136 TG, GRAMD1B rs850294 T, TRAIP rs62260729 C) nominally associated (P < 0.05) with CSA of fast-twitch muscle fibers, fat-free mass and handgrip strength. Based on these five SNPs, the number of testosterone-increasing alleles was positively associated with testosterone levels in male athletes (P = 0.048) and greater strength performance in weightlifters (P = 0.017). Moreover, the proportion of participants with ≥ 2 testosterone-increasing alleles was higher in power athletes compared to controls (68.9 vs. 55.6%; P = 0.012). Conclusion Testosterone-related SNPs are associated with muscle fiber size, fat-free mass and strength, which combined can partially contribute to a greater predisposition to strength/power sports.
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Russo, A., M. Autelitano, A. Bellini i L. Bisanti. "Estimate of population coverage with the prostate specific antigen (PSA) test to screen for prostate cancer in a metropolitan area of northern Italy". Journal of Medical Screening 9, nr 4 (1.12.2002): 179–80. http://dx.doi.org/10.1136/jms.9.4.179.

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The use of the prostate specific antigen (PSA) test in the period 1999–2000 in a population of 311 822 men, aged 40 years or more, resident in Milan, Italy, was examined. Data were drawn from the outpatient database of the local health information system. A total of 139 350 PSA tests were used in 83 943 subjects. Overall, 26.9% of the male population aged 40 or older, with no history of prostate cancer, received a PSA test in the 2 year study period. For subjects older than 50 the rate rose to 34%. Results show a high coverage of the male population in northern Italy with screening using the PSA test for prostate cancer.
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Bharat, A., K. Narayanan, N. Benshoff, J. Dietz, W. Gillanders, T. Fleming i T. Mohanakumar. "Inducing mammaglobin-A (mamA) specific HLA class I tetramer positive CD8+cytotoxic T-lymphocytes (CTL) against breast cancer by DNA vaccination". Journal of Clinical Oncology 24, nr 18_suppl (20.06.2006): 2522. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.2522.

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2522 Background: We recently reported that DNA vaccination using MamA, a highly expressed human (hu) breast cancer specific protein, leads to immunity against breast cancer. Here we demonstrate that the induction of breast cancer immunity following MamA DNA vaccination occurs through the expansion of CD8+ CTL by using HLA class I MamA peptide tetramers. Methods: HLA-A2+huCD8+ double transgenic mice received four (100μg) two-weekly IM injections of PCI-neo vector cloned with hu MamA gene. HLA-A2 tetramers (tet) carrying an immunodominant Mam2.1 peptide (LIYDSSLCDL) were used to monitor development of mam-A specific CD8+ T cells. Specificity of tetramers was tested against CD8+ CTL lines developed in vitro by stimulation of normal hu HLA-A2+ peripheral blood lymphocytes with TAP-2 deficient T2 cells pulsed with pooled MamA HLA-A2 binding peptides. Results: There was a sequential expansion of Mam2.1 tet+CD8+ T cells during stimulation of hu PBLs with MamA peptides in vitro (<1% pre-stimulation to >15% after six stimulations). These Mam2.1 tet+CD8+ T cells were HLA-A2 restricted and MamA specific since they revealed cytotoxicity only towards UACC-822 (HLA-A2+MamA+, 75% lysis) but not MCF-7 (A2+MamA−) or DU-4475 (A2−MamA+) breast cancer cell lines. In contrast, there was no binding of MamA peptide tetramers to control Flu-specific CD8+ CTL lines (<1%). MamA DNA vaccination, but not PCI-neo vector alone, of HLA-A2+huCD8+ mice lead to the expansion of Mam2.1 tet+CD8+ T cells (<0.7% pre-vaccination to >2.5% post-vaccination) in the peripheral blood that revealed in vitro cytotoxicity against UACC-822 (70% lysis) but not against DU-4475 or MCF-7 breast cancer cell lines. Adoptive transfer of both whole splenocytes or fractionated CD8+ T cells from vaccinated mice into immunodeficient SCID-beige mice with previously established subcutaneous hu breast cancer colonies lead to tumor infiltration of tet+CD8+ CTLs and, at 4-weeks, at least 80% tumor regression of UACC-822 but not DU4475 or MCF-7 colonies. Conclusions: MamA DNA vaccination resulted in the expansion of CD8+ CTL. The CD8+ CTL were HLA class I MamA peptide tetramer positive, HLA class I restricted and specifically lysed mamA+ human breast cancer cells both in vitro and in vivo. No significant financial relationships to disclose.
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Summers, Carol. "Barbara Harlow and Mia Carter, eds. Archives of Empire. Vol. 2: The Scramble for Africa. Durham, NC, and London: Duke University Press, 2003. 821 pp. ISBN: 0-822-33152-7 (hbk.); 0-822-33189-6 (pbk)." Itinerario 29, nr 2 (lipiec 2005): 108–10. http://dx.doi.org/10.1017/s0165115300023718.

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Gonzalez, Jeffrey S., Erica Shreck, Christina Psaros i Steven Safren. "23. Distress and Diabetes Treatment Adherence: A Mediating Role for Perceived Control in Adults with Type 2 Diabetes (822-P)". Nederlands Tijdschrift voor Diabetologie 12, nr 4 (październik 2014): 26–27. http://dx.doi.org/10.1007/s12467-014-0048-8.

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Bleiker, Eveline M. A., Henk M. Van der Ploeg, Herman J. Adèr, Willem A. J. van Daal i Jan H. C. L. Hendriks. "Personality Traits of Women with Breast Cancer: Before and after Diagnosis". Psychological Reports 76, nr 3_suppl (czerwiec 1995): 1139–46. http://dx.doi.org/10.2466/pr0.1995.76.3c.1139.

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The aim of this study was to investigate the extent to which the diagnosis of breast cancer influences the self-assessment of personality traits by patients. In 1989 and 1990, all female inhabitants of Nijmegen aged 43 years and over were invited to participate in a population screening for breast cancer and were asked to complete a personality questionnaire. During 1989–1992, 25 women who were diagnosed as having breast cancer were psychologically assessed for a second time 1 1/2 years after diagnosis. A control group of 822 healthy women also completed the questionnaire twice. A statistically significant decrease in scores on three scales (Rationality, Emotional Expression-out, and Emotional-Control) was reported by the patient group compared to the control group.
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31

Mulkey, Daniel K., Richard A. Henderson, James E. Olson, Robert W. Putnam i Jay B. Dean. "Oxygen measurements in brain stem slices exposed to normobaric hyperoxia and hyperbaric oxygen". Journal of Applied Physiology 90, nr 5 (1.05.2001): 1887–99. http://dx.doi.org/10.1152/jappl.2001.90.5.1887.

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We previously reported ( J Appl Physiol 89: 807–822, 2000) that ≤10 min of hyperbaric oxygen (HBO2; ≤2,468 Torr) stimulates solitary complex neurons. To better define the hyperoxic stimulus, we measured Po 2 in the solitary complex of 300-μm-thick rat medullary slices, using polarographic carbon fiber microelectrodes, during perfusion with media having Po 2 values ranging from 156 to 2,468 Torr. Under control conditions, slices equilibrated with 95% O2at barometric pressure of 1 atmospheres absolute had minimum Po 2 values at their centers (291 ± 20 Torr) that were ∼10-fold greater than Po 2values measured in the intact central nervous system (10–34 Torr). During HBO2, Po 2 increased at the center of the slice from 616 ± 16 to 1,517 ± 15 Torr. Tissue oxygen consumption tended to decrease at medium Po 2 ≥ 1,675 Torr to levels not different from values measured at Po 2 found in all media in metabolically poisoned slices (2-deoxy-d-glucose and antimycin A). We conclude that control medium used in most brain slice studies is hyperoxic at normobaric pressure. During HBO2, slice Po 2 increases to levels that appear to reduce metabolism.
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32

Henderson, Benjamin, i Kenji Bekki. "SIGNIFICANT ENHANCEMENT OF H 2 FORMATION IN DISK GALAXIES UNDER STRONG RAM PRESSURE". Astrophysical Journal 822, nr 2 (6.05.2016): L33. http://dx.doi.org/10.3847/2041-8205/822/2/l33.

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33

Aggarwal, Poornima, David K. Taylor, Charles W. Smith, Colin J. Joyce, Meghan K. Fisher, Philip A. Isenberg, Bernard J. Vasquez, Nathan A. Schwadron, Bradford E. Cannon i John D. Richardson. "VOYAGEROBSERVATIONS OF MAGNETIC WAVES DUE TO NEWBORN INTERSTELLAR PICKUP IONS: 2–6 au". Astrophysical Journal 822, nr 2 (11.05.2016): 94. http://dx.doi.org/10.3847/0004-637x/822/2/94.

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Suemitsu, Ryuichi, Taro Sakoguchi, Keiko Morikawa, Masafumi Yamaguchi, Hiroyuki Tanaka i Sadanori Takeo. "Effect of Body Mass Index on Perioperative Complications in Thoracic Surgery". Asian Cardiovascular and Thoracic Annals 16, nr 6 (grudzień 2008): 463–67. http://dx.doi.org/10.1177/021849230801600607.

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Obesity is perceived as a risk factor in general thoracic surgery. We conducted a single-center retrospective evaluation of perioperative complications in 822 patients who underwent thoracic surgery between 2000 and 2005. According to body mass index, 82 were underweight (< 18.5 kg·m−2), 568 were normal (18.5–24.9 kg·m−2), 155 were overweight (25.0–29.9 kg·m−2), and 17 were obese (≥30 kg·m−2). A significant increase in preoperative comorbidity (hypertension and ischemic heart disease) was observed with increasing body mass index. There was no significant difference in operation time or length of stay in the operating room, but extubation time was significantly different among the 4 groups. Of the intraoperative complications, alveolar-arterial oxygen difference increased significantly with increasing obesity, and hypoxia was least common in the normal group. Postoperatively, there was more pulmonary leakage in the underweight group and less pneumonia in the normal group. Both the underweight and the obese are at increased risk of perioperative complications and need to be carefully observed and managed intraoperatively and postoperatively.
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35

Kimbel, William H., i Yoel Rak. "The cranial base of Australopithecus afarensis : new insights from the female skull". Philosophical Transactions of the Royal Society B: Biological Sciences 365, nr 1556 (27.10.2010): 3365–76. http://dx.doi.org/10.1098/rstb.2010.0070.

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Cranial base morphology differs among hominoids in ways that are usually attributed to some combination of an enlarged brain, retracted face and upright locomotion in humans. The human foramen magnum is anteriorly inclined and, with the occipital condyles, is forwardly located on a broad, short and flexed basicranium; the petrous elements are coronally rotated; the glenoid region is topographically complex; the nuchal lines are low; and the nuchal plane is horizontal. Australopithecus afarensis (3.7–3.0 Ma) is the earliest known species of the australopith grade in which the adult cranial base can be assessed comprehensively. This region of the adult skull was known from fragments in the 1970s, but renewed fieldwork beginning in the 1990s at the Hadar site, Ethiopia (3.4–3.0 Ma), recovered two nearly complete crania and major portions of a third, each associated with a mandible. These new specimens confirm that in small-brained, bipedal Australopithecus the foramen magnum and occipital condyles were anteriorly sited, as in humans, but without the foramen's forward inclination. In the large male A.L. 444-2 this is associated with a short basal axis, a bilateral expansion of the base, and an inferiorly rotated, flexed occipital squama—all derived characters shared by later australopiths and humans. However, in A.L. 822-1 (a female) a more primitive morphology is present: although the foramen and condyles reside anteriorly on a short base, the nuchal lines are very high, the nuchal plane is very steep, and the base is as relatively narrow centrally. A.L. 822-1 illuminates fragmentary specimens in the 1970s Hadar collection that hint at aspects of this primitive suite, suggesting that it is a common pattern in the A. afarensis hypodigm. We explore the implications of these specimens for sexual dimorphism and evolutionary scenarios of functional integration in the hominin cranial base.
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Febriana, A., S. Sutopo i E. Kurnianto. "Identification of BMP15 Exon 2 for fecundity traits by PCR-RFLP and nucleotide sequencies in Kejobong goat". Journal of the Indonesian Tropical Animal Agriculture 42, nr 4 (19.12.2017): 220. http://dx.doi.org/10.14710/jitaa.42.4.220-226.

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Kejobong goat is known as prolific and high productivity goat breed in Indonesia. PCR-RFLP and sequencing technique was established in the present study to accomplish the polymorphisms of Bone Morphogenetic Protein 15 (BMP15) gene exon 2 on Kejobong goat does. The blood samples was collected from 48 Kejobong does which were selected based on their litter size. The size of PCR amplification of BMP15 gene exon 2 was 837 bp. The product of PCR-RFLP technique digested by HinfI enzyme showed that the samples were monomorphic. Authentication result using nucleotide sequencing found 4 substitution (A391G, C464G, T828C and C830G), 1 alignment gap (site 817) and 1 insertion nucleotide (site 822). This mutations caused 6 haplotypes formatted. The mutants of BMP15 exon 2 on Kejobong goats indicated that this breed had their own mutation controling the prolific trait. The phylogenetic tree build on the sequences of BMP15 gene exon 2 of Kejobong goats was grouped into 3 clusters. The alignment gap indicated to be the specific marker for the prolific trait (duplet) in Kejobong goat. The particular insertion site could be the recognition site of Kejobong goat based on BMP15 exon 2.
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37

Becker, Márcia R., Sergio A. Arguello i Janine C. Padilha. "Hydrogen production by water electrolysis using TEA.PS-BF4 ionic liquid and alternative electrocatalysts". International Journal of Advanced Engineering Research and Science 9, nr 9 (2022): 191–96. http://dx.doi.org/10.22161/ijaers.99.17.

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Studies on water electrolysis are in permanent development to improve its processes with electrodes and electrolytes that offer lower overpotential values. This work uses an ionic liquid (IL) – tetrafluoroborate of 3-triethylammonium-propane sulfonic acid (TEA-PS.BF4) – as electrolyte and studies the effect of different electroactive cathode materials on hydrogen production, such as platinum (Pt), nickel (Ni), palladium (Pd), gold (Au) or silver (Ag). Water electrolysis was performed in a Hoffman Cell and analysed by chronoamperometry (CA) and linear sweep voltammetry (LSV) techniques. For the electrodes studied here, in a 0.1 M TEA-PS.BF4 solution, current density (j) values were 252-404 mA cm-2; for 0.3 M TEA-PS.BF4, values were 406-728 mA cm-2; and for 0.7 M, values were 822-1055 mA cm-2. Low activation energy (Ea) of 5 kJ mol-1 was found for the Au cathode, 9 kJ mol-1 for Pt and Ag, and 24 kJ mol-1 for Ni and Pd. Results show that the Ni electrode is an attractive alternative for hydrogen production by water electrolysis and using IL as electrolyte.
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38

Francis, Adam A., Bhupesh Mehta i David Zenisek. "Development of new peptide-based tools for studying synaptic ribbon function". Journal of Neurophysiology 106, nr 2 (sierpień 2011): 1028–37. http://dx.doi.org/10.1152/jn.00255.2011.

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Synaptic ribbons are proteinaceous specialized electron-dense presynaptic structures found in nonspiking sensory cells of the vertebrate nervous system. Understanding the function of these structures is an active area of research (reviewed in Matthews G, Fuchs P. Nat Rev Neurosci 11: 812–822, 2010). Previous work had shown that ribbons could be effectively labeled and visualized using peptides that bind to the synaptic ribbon protein RIBEYE via a PXDLS motif (Zenisek D, Horst NK, Merrifield C, Sterling P, Matthews G. J Neurosci 24: 9752–9759, 2004). Here, we expand on the previous work to develop new tools and strategies for 1) better visualizing synaptic ribbons, and 2) monitoring and manipulating calcium on the synaptic ribbon. Specifically, we developed a new higher-affinity peptide-based label for visualizing ribbons in live cells and two strategies for localizing calcium indicators to the synaptic ribbon.
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39

Samal, S., S. Sahoo i C. S. K. Mishra. "Evaluating the effect of monocrotophos and glyphosate on microbial population and certain important exoenzyme activities in soil". Journal of Environmental Biology 40, nr 2 (1.03.2019): 226–34. http://dx.doi.org/10.22438/jeb/40/2/mrn-822.

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40

Lehtinen, K., U. Bach, K. Muinonen, M. Poutanen i L. Petrov. "ASTEROID SIZING BY RADIOGALAXY OCCULTATION AT 5 GHZ". Astrophysical Journal 822, nr 2 (2.05.2016): L21. http://dx.doi.org/10.3847/2041-8205/822/2/l21.

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41

Masada, Youhei, i Takayoshi Sano. "SPONTANEOUS FORMATION OF SURFACE MAGNETIC STRUCTURE FROM LARGE-SCALE DYNAMO IN STRONGLY STRATIFIED CONVECTION". Astrophysical Journal 822, nr 2 (2.05.2016): L22. http://dx.doi.org/10.3847/2041-8205/822/2/l22.

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42

Panesar, Navdeep K., Alphonse C. Sterling i Ronald L. Moore. "HOMOLOGOUS JET-DRIVEN CORONAL MASS EJECTIONS FROM SOLAR ACTIVE REGION 12192". Astrophysical Journal 822, nr 2 (2.05.2016): L23. http://dx.doi.org/10.3847/2041-8205/822/2/l23.

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43

Naoz, Smadar, Tassos Fragos, Aaron Geller, Alexander P. Stephan i Frederic A. Rasio. "FORMATION OF BLACK HOLE LOW-MASS X-RAY BINARIES IN HIERARCHICAL TRIPLE SYSTEMS". Astrophysical Journal 822, nr 2 (5.05.2016): L24. http://dx.doi.org/10.3847/2041-8205/822/2/l24.

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44

Liu, F. S., Dongfei Jiang, Yicheng Guo, David C. Koo, S. M. Faber, Xianzhong Zheng, Hassen M. Yesuf i in. "THE UV–OPTICAL COLOR GRADIENTS IN STAR-FORMING GALAXIES AT 0.5 < z < 1.5: ORIGINS AND LINK TO GALAXY ASSEMBLY". Astrophysical Journal 822, nr 2 (5.05.2016): L25. http://dx.doi.org/10.3847/2041-8205/822/2/l25.

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45

Bigiel, Frank, Adam K. Leroy, Maria J. Jiménez-Donaire, Jérôme Pety, Antonio Usero, Diane Cormier, Alberto Bolatto i in. "THE EMPIRE SURVEY: SYSTEMATIC VARIATIONS IN THE DENSE GAS FRACTION AND STAR FORMATION EFFICIENCY FROM FULL-DISK MAPPING OF M51". Astrophysical Journal 822, nr 2 (5.05.2016): L26. http://dx.doi.org/10.3847/2041-8205/822/2/l26.

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46

Gianninas, A., Brandon Curd, G. Fontaine, Warren R. Brown i Mukremin Kilic. "DISCOVERY OF THREE PULSATING, MIXED-ATMOSPHERE, EXTREMELY LOW-MASS WHITE DWARF PRECURSORS". Astrophysical Journal 822, nr 2 (5.05.2016): L27. http://dx.doi.org/10.3847/2041-8205/822/2/l27.

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Barth, Aaron J., Benjamin D. Boizelle, Jeremy Darling, Andrew J. Baker, David A. Buote, Luis C. Ho i Jonelle L. Walsh. "MEASUREMENT OF THE BLACK HOLE MASS IN NGC 1332 FROM ALMA OBSERVATIONS AT 0.044 ARCSECOND RESOLUTION". Astrophysical Journal 822, nr 2 (5.05.2016): L28. http://dx.doi.org/10.3847/2041-8205/822/2/l28.

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48

Rameau, Julien, Eric L. Nielsen, Robert J. De Rosa, Sarah C. Blunt, Jenny Patience, René Doyon, James R. Graham i in. "CONSTRAINTS ON THE ARCHITECTURE OF THE HD 95086 PLANETARY SYSTEM WITH THE GEMINI PLANET IMAGER". Astrophysical Journal 822, nr 2 (6.05.2016): L29. http://dx.doi.org/10.3847/2041-8205/822/2/l29.

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49

Fontani, F., V. M. Rivilla, P. Caselli, A. Vasyunin i A. Palau. "PHOSPHORUS-BEARING MOLECULES IN MASSIVE DENSE CORES". Astrophysical Journal 822, nr 2 (6.05.2016): L30. http://dx.doi.org/10.3847/2041-8205/822/2/l30.

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Peng, Eric W., i Sungsoon Lim. "A RICH GLOBULAR CLUSTER SYSTEM IN DRAGONFLY 17: ARE ULTRA-DIFFUSE GALAXIES PURE STELLAR HALOS?" Astrophysical Journal 822, nr 2 (6.05.2016): L31. http://dx.doi.org/10.3847/2041-8205/822/2/l31.

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