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1
Cromaz, Mario. "High-spin states in ¹§6§7Hf and ¹§7³§,¹§7§4W". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ27900.pdf.
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David, Karine. "Mise au point analytique de la mesure du rapport zr/hf dans les roches terrestres et extraterrestres par dilution isotopique en spectrometrie de masse a thermo-ionisation et a source plasma en multicollection. Utilisation des traceurs chimique zr/hf et isotopique #1#7#6hf/#1#7#7hf". Paris 7, 1997. http://www.theses.fr/1997PA077026.
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Apres avoir develloppe un protocole de purification du zirconium et de l'hafnium par chromatographie d'echange d'ions permettant de mesurer le rapport zr/hf par dilution isotopique (traceur double zirconium-hafnium) en spectrometrie de masse a thermoionisation (vg 354) et a source plasma avec un analyseur a double focalisation et une detection en multicollection (plasma 54), avec une precision a 2,5&, nous avons mesure les rapports chimique zr/hf et isotopique #1#7#6hf/#1#7#7hf dans des roches terrestres (basaltes oceaniques, roches et sediments continentaux) et extraterrestres (chondrites carbonees orgueil, allende et murchison). Les rapports zr/hf des roches terrestres sont significativement differents de la valeur chondritique. La gamme de variations des rapports zr/hf des basaltes de rides medio-oceaniques (morb) qui est similaire a celle du materiel continental montre que le rapport zr/hf a peu fractionne lors de l'extraction de la croute continentale. Afin d'identifier les differents processus (differenciation magmatique, fusion partielle et heterogeneites de sources) qui seraient succeptibles de fractionner le rapport zr/hf et d'expliquer les rapports plus eleves qui sont mesures dans les basaltes d'iles oceaniques, nous avons couple le rapport zr/hf avec differents traceurs geochimiques. L'etude effectuee sur les basaltes d'iles oceaniques differencies montre que le rapport zr/hf augmente condiserablement lors de la cristallisation de clinopyroxene. D'autre part, les rapports zr/hf plus eleves dans les oib que dans les morb suggerent egalement un fractionnement du rapport zr/hf lors de la fusion partielle, avec un coefficient de partage global solide/liquide du zirconium inferieur a celui de l'hafnium. A partir de l'etude couplee entre les rapports zr/hf et #1#7#6hf/#1#7#7hf effectuee sur l'ensemble des roches, nous suggerons que la presence de liquides carbonatitiques dans la source des oib produit un fractionnement important du rapport zr/hf lors de leur genese.
3
Ambrosio, Simone Rodrigues. "Métodos bacteriológicos aplicados à tuberculose bovina: comparação de três métodos de descontaminação e de três protocolos para criopreservação de isolados". Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-31102006-162337/.
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Dada a importância do Programa Nacional de Controle e Erradicação da Brucelose e Tuberculose (PNCEBT), a necessidade de uma eficiente caracterização bacteriológica dos focos como ponto fundamental do sistema de vigilância e as dificuldades encontradas pelos laboratórios quanto aos métodos de isolamento de Mycobacterium bovis fizeram crescer o interesse do meio científico por estudos, sobretudo moleculares, de isolados M. bovis. Para a realização dessas técnicas moleculares, é necessária abundância de massa bacilar, obtida através da manutenção dos isolados em laboratório e repiques em meios de cultura. Entretanto o crescimento fastidioso do M. bovis em meios de cultura traz grandes dificuldades para essas operações. Assim sendo, o presente estudo teve por objetivos: 1º) Comparar três métodos de descontaminação para homogeneizados de órgãos, etapa que precede a semeadura em meios de cultura, onde 60 amostras de tecidos com lesões granulomatosas, provenientes de abatedouros bovinos do Estado de São Paulo, foram colhidas e imersas em solução saturada de Borato de Sódio e transportadas para o Laboratório de Zoonoses Bacterianas do VPS-FMVZ-USP, onde foram processadas até 60 dias após a colheita. Essas amostras foram submetidas a três métodos de descontaminação: Básico (NaOH 4%), Ácido (H2SO4 12%) e 1- Hexadecylpyridinium chloride a 1,5% (HPC) e o quarto método foi representado pela simples diluição com solução salina (controle). Os resultados foram submetidos à comparação de proporções, pelo teste de χ², na qual verificou-se que o método HPC foi o que apresentou menor proporção de contaminação (3%) e maior proporção de sucesso para isolamento de BAAR (40%). 2º) Comparar três diferentes meios criopreservates para M. bovis, foram utilizados 16 isolados identificados pela técnica de spoligotyping. Cada um desses isolados foi solubilizado em três meios (solução salina, 7H9 original e 7H9 modificado), e armazenado em três diferentes temperaturas (-20ºC, -80ºC e -196ºC), sendo descongelado em três diferentes tempos (45, 90 e 120 dias de congelamento). Antes do congelamento e após o descongelamento foram feitos cultivos quantitativos em meios de Stonebrink Leslie. Os porcentuais de redução de Unidades Formadoras de Colônias (UFC) nas diferentes condições foram calculados e comparados entre si através de métodos paramétricos e não-paramétricos. Os resultados obtidos foram: na análise da variável tempo, em 90 dias de congelamento foi observada uma maior proporção de perda de M. bovis, quando comparado ao tempo 120 dias (p=0,0002); na análise da variável temperatura, foi observada uma diferença estatística significativa entre as proporções de perda média nas temperaturas de -20ºC e -80ºC (p<0,05); na análise da variável meio, foi observada uma diferença significativa (p=0,044) entre os meios A e C, para 45 dias de congelamento e -20ºC de temperatura de criopreservação. Embora as medianas dos porcentuais de perdas de UFC terem sido sempre inferiores a 4,2%, permitiram sugerir que o melhor protocolo de criopreservação de isolados de M. bovis é solubilizá-los em 7H9 modificado e mantê-los à temperatura de -20ºCIn the context of the National Program of Control and Eradication of Brucellosis and Tuberculosis (PNCEBT), the necessity of an efficient bacteriologic characterization of the infected herds as a cornerstone of the monitoring system and the difficulties faced by the laboratories regarding the methods for Mycobacterium bovis isolation led to a growing interest for scientific studies, especially molecular, of M. bovis isolates. To use these molecular techniques it is necessary to have an abundant bacillary mass, obtained through the maintenance of isolates in laboratory and replication in culture media. However the fastidious growth of M. bovis in culture media brings out great difficulties for these activities. Thus, the present study has the following objectives: First, to compare three decontamination methods for organ homogenates, phase that precedes the sowing in culture media, 60 samples of tissues with granulomatosis injuries, proceeding from bovine slaughterhouses in the State of São Paulo, were obtained, immersed in sodium borato saturated solution and transported to the Laboratório de Zoonoses Bacterianas of the VPS-FMVZ-USP, where they were processed up to 60 days after the sampling. These samples were submitted to three methods of decontamination: Basic NaOH 4%, Acid (H2SO4 12%) and 1- Hexadecylpyridinium chloride (HPC) 1.5% and a simple dilution with saline solution (control method). The results were analysed by means of the &chi test to compare proportions, and it was verified that HPC method presented the smallest proportion of contamination (3%) and the greatest proportion of success for M. bovis isolation (40%). Second, to compare three different cryopreservation media for M. bovis, 16 isolates identified by the technique of spoligotyping were used. Each one of these isolates was solubilized in three media (original saline solution, 7H9 and 7H9 modified), and stored in three different temperatures (-20ºC, -80ºC and -196ordm;C), and defrosted in three different time periods (45, 90 and 120 days of freezing). Before the freezing and after the unfreezing, quantitative cultivations in Stonebrink Leslie media were carried out. The proportions of Colony-Forming Units (CFU) loss in the different conditions were calculated and compared with one another through parametric and non-parametric methods. The results obtained were: in the analysis of the variable time, at 90 days of freezing a bigger proportion of CFU loss was observed when compared to 120 days (p=0,0002); in the analysis of the variable temperature, a statistically significant difference was observed between the average proportions of CFU loss for the temperatures of -20ºC and -80ºC (p<0,05); in the analysis of the variable media, a significant difference was observed (p=0,044) between the media A and C, for 45 days of freezing and -20ºC of cryopreservation temperature. Althougth the medium ones of the proportion of losses of CFU to always have been inferior 4,2%, had allowed to suggest that the best protocol for cryopreservation of M. bovis isolates is to solubilize them in 7H9 modified medium and to keep them at a temperature of -20ºC
4
Low, David Wayne. "Application of transyt-7F on a downtown bus loop". Thesis, Georgia Institute of Technology, 1985. http://hdl.handle.net/1853/22343.
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Moreira, Catarina Alfaya. "DESENVOLVIMENTO DE PROTEÍNA SINTÉTICA QUIMÉRICA BASEADA EM TALE (TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR) PARA APLICAÇÃO EM SISTEMA BIOSSENSOR DE DNA. 72f 2017". Instituto de Ciências da Saúde, 2017. http://repositorio.ufba.br/ri/handle/ri/25293.
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As abordagens de Biologia Sintética possuem potencial de aumentar a produção de ferramentas diagnósticas adequadas para utilização na prática, como os biossensores de DNA. O controle dos sistemas biológicos permite o aprimoramento de tecnologias em uso e surgimento de novas tecnologias, como o diagnóstico molecular através da identificação de sequências específicas de DNA. A maioria dos métodos moleculares de diagnóstico de DNA se baseiam em hibridização. Contudo, atualmente, as proteínas ligadoras de DNA tem tido destaque, devido às suas numerosas vantagens. As principais vantagens são a identificação de sequências em DNA dupla-fita, eliminando o passo de desnaturação, e a alta especificidade pelo alvo. Neste contexto, o objetivo deste trabalho foi desenvolver uma proteína sintética quimérica para aplicação em sistema biossensor de DNA que permitirá rápida identificação de uma sequência específica de DNA de Corynebacterium striatum, um importante patógeno emergente. Foi construída, neste estudo, uma proteína quimérica biossensora composta por: (I) um domínio de ligação ao DNA derivado de proteínas TALEs (proteínas efetoras do tipo ativadores transcricionais) o qual reconhece especificamente uma sequência de 18 pb de um gene único de C.striatum codificador de uma permease para transporte de ferro; combinado a (II) uma cromoproteína tsPurple (Tinsel Purple) para permitir detecção visual da sequência alvo. Para construção do gene codificador da proteína TALE específica, o gene específico de C. striatum foi analisado com a ferramenta Tal Effector Nucleotide Targeter (Cornell University) e uma sequência-alvo de 18pb foi definida. A construção de domínios TAL foi realizada utilizando a ferramenta GeneArtTM Perfect Match TAL (Thermo Scientific); o gene sintético encontra-se clonado no plasmídeo pTALE. Para construir as sequências gênicas quiméricas, foram desenhados primers de PCR para isolamento da sequência da tsPurple com a adição de sítios artificiais de restrição para EcoRI e BamHI; os produtos de PCR digeridos foram clonados no plasmídeo pTALE, downstream à sequência da TALE específica. Essas sequências fusionadas foram então sub-clonadas em um vetor de expressão pDESTTM17, através de recombinação utilizando tecnologia Gateway para expressão das proteínas quiméricas. A expressão da proteína quimérica foi induzida pela adição de 1mM de IPTG. A expressão da proteína quimérica foi confirmada através de análises de SDS PAGE 10% , que demonstraram a superexpressão da proteína esperada de 151kDa; além disso, foi observada a forte coloração roxa no precipitado bacteriano, em razão da funcionalidade da cromoproteína TsPurple.
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Moskaluk, John. "Arterial priority option for the TRANSYT-7F traffic-signal-timing program". Diss., Georgia Institute of Technology, 1987. http://hdl.handle.net/1853/19428.
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Touati, Fayçal. "Intégration d'antennes sur silicium en technologie BiCMOS pour des objets communicants de faible puissance au delà de 10 GHz". Grenoble INPG, 2006. http://www.theses.fr/2006INPG0032.
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Les Objets Communicants sont des dispositifs dotés de capacités de communication et de traitement de l'information. La transmission RF des données se fait souvent dans des milieux confinés (propagation indoor) et dans des bandes de fréquences au-delà des standards de la téléphonie mobile. De nos jours, les puces à front-end radio assurant la communication comprennent des éléments passifs tels que les inductances et les condensateurs, l'idée d'intégrer (intégration au sens microélectronique) la partie antenne et sa logique de commutation semble être une piste intéressante pour des applications à des fréquences élevées, dans le but de proposer des dispositifs RF destinés aux Objets Communicants. Aussi, cette intégration permettrait de disposer d'un seul processus de fabrication, limitant de ce fait l'adjonction d'éléments externes réduisant d'autant les coûts de fabrication du fait que la partie radio serait réalisée d'un seul bloc. Le but de la thèse est de simuler, concevoir, et caractériser expérimentalement des antennes dipôles intégrées et couplées à des VCO sur des puces en silicium en utilisant des technologies « standards» du type BiCMOS. La gamme de fréquences envisagées va de 10 GHz à 20 GHz. Il s'agit au terme de cette étude, d'être en mesure de déterminer les effets des paramètres technologiques du substrat silicium sur les performances de rayonnement de l'antenne intégrée, et de proposer des solutions d'intégration qui optimisent les performances de cet élémentThe RF transmission of the data are subject to indoor propagation at high frequency bands, beyond mobile telephony spectrum standards. Nowaday, the onchip radio front-end contains passive components such like, spiral inductors and capacitors. Thinking about integrating (in terms of microelectronic integration) the antenna including its switching capabilities, seems to be interesting in the field of Smart Deviees operating at high frequency ranges. The aim of this study, is to simulate, design and measure dipole antennas directly coupled to VCO's, using standard (industrial type) silicon BiCMOS technology. The considered operating frequencies are in the range of 10 to 20 GHz. By achieving this study, the technological issues for antenna integration will be highlighted and the capabilities of the considered standard BiCMOS microelectronic technologies will be investigated to allow on-chip antenna implementation with acceptable performances
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Skaza, Fore. "Structure du noyau exotique 8HE par les réactions directes 8HE(P,P')8HE, 8HE(P,D)7HE et 8HE(P,T)6HE". Paris 11, 2004. http://www.theses.fr/2004PA112173.
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Les réactions directes de diffusions élastique et inélastique d'un faisceau d'8He sur une cible de protons ont été mesurées au GANIL. Le faisceau d'8He produit par le dispositif SPIRAL à une énergie de 15. 6 A. MeV était envoyé sur une cible de protons. Le dispositif expérimental était composé de l'ensemble des huit télescopes MUST pour la détection des particules légères de recul, d'un ensemble de six lattes de scintillateurs plastiques pour la détection des éjectiles lourds et de deux détecteurs de faisceaux CATS pour la reconstruction événement par événement de la position et de l'angle d'incidence du faisceau sur la cible. Ce dispositif a aussi permis de mesurer les réactions de transfert d'un neutron vers l'7He et de deux neutrons vers l'6He. Les spectres en énergie d'excitation des 6,7,8He ont été mesurés ainsi que les distributions angulaires associées à chaque voie de réaction. Les états observés pour les trois noyaux sont en accord avec les données de la littérature. Nous indiquons la présence d'un premier état excité dans l'7He à 0. 9 MeV et nous donnons aussi pour la première fois la position d'un second état excité de l'8He à 5. 4 MeV, état dont la présence était seulement suggérée par une expérience précédente. Des calculs CCBA ont permis d'extraire un facteur spectroscopique de 4. 4±1. 3 pour le transfert d'un neutron de l'8He vers l'7He, valeur en accord avec une sous-couche p3/2 fermée pour l'8He. Pour l'analyse des distributions angulaires de diffusion élastique et inélastique, il s'est avéré nécessaire de prendre en compte explicitement dans le formalisme, via des calculs en voies couplées, les couplages à la réaction de transfert d'un neutronThe elastic and inelastic scattering reactions of an 8He beam on a proton target were measured at GANIL. The 8He beam produced by the SPIRAL facility at an energy of 15. 6 A. MeV impinged on a proton target and the recoil proton was detected in an array of eight telescopes, the wall of strip-detectors, MUST, devoted to the detection of light charged. The experimental setup was also by a plastic scintillator wall for the detection of heavy projectile, and by two beam tracking detectors CATS for the measure event by event of the incident position and angle of the beam on the target. This setup allowed also to measure the one and two neutron transfer reactions 8He(p,d)7He and 8He(p,t)6He. The excitation energy spectrum for 6,7,8He and the angular distributions associated to each reaction were measured. The observed excited states are in agreement with the data of the literature. We indicate the presence of a first excited state for 7He at 0. 9 MeV and we give for the first time the position of a second excited state in 8He; the presence of such state was just suggested in a previous experiment. From CCBA calculations a spectroscopic factor of 4. 4±1. 4 for the pick-up of one neutron from 8He to 7He was extracted from the data. This value is in agreement with a closed p3/2 sub-shell for 8He. To analyse successfully the angular distributions for elastic and inelastic scattering, it was necessary to take into account in the formalism, used to describe the reactions, the couplings to the one neutron transfer reaction. This was done via coupled channels reactions calculations
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Poblete, González Cristián Ignacio. "Estudio de las especies transientes generadas durante la fotorreducción por aminas de oxoisoaporfinas : 5-metoxi-7H-dibenzo[de,h]quinolin-7-ona y 7H-dibenzo[de,h]quinolin-7-ona". Tesis, Universidad de Chile, 2007. http://repositorio.uchile.cl/handle/2250/105633.
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Memoria para optar al título de Químico FarmacéuticoLos sistemas fotosintéticos naturales y artificiales en los cuales la energía de la luz es colectada y almacenada como energía química, es un proceso de conversión que es iniciado con la transferencia fotoinducida de un electrón, que es seguida por otras etapas químicas que permiten la separación y estabilización cinética de los llamados “sistemas de carga separada”. Este es el caso de las 7H-dibenzo[de,h]quinolin-7-onas, conocidas como oxoisoaporfinas, que al ser fotorreducidas en presencia de aminas generan fotoproductos iónicos metaestables, capaces de almacenar una fracción apreciable de la energía de fotoexcitación. Los fotoproductos que se forman vía una transferencia secuencial de electrón-protón-electrón, revierten térmicamente a las oxoisoaporfinas originales, generando productos de oxidación de la amina. La reconversión del fotoproducto metaestable permite la reutilización del sistema en tanto exista amina remanente que reaccione con la oxoisoaporfina regenerada. Se estudiaron los transientes de la fotorreducción por aminas de la oxoisoaporfina y 5-metoxi-oxoisoaporfina, el triplete excitado, el anión radical y el radical neutro. Los intermediarios transientes fueron generados por láser flash-fotólisis, en presencia y ausencia de aminas terciarias, con y sin hidrógenos alfa. Si la amina no es capaz de donar protones, la reacción procederá sólo hasta la formación de A-·. Se identificaron y se caracterizaron los tripletes y radicales de las dos oxoisoaporfinas en estudio y se determinaron los parámetros cinéticos
Natural and artificial photosynthetic systems in which the energy of the light is collected and stored as chemical energy, is a process beggining with a photoinduced single electron transfer, PET, followed by other stages wich allow the separation and kinetic stabilization of “separate-charge systems”. This is the case of 7H-dibenzo[de,h]quinolin-7-onas, well-known as oxoisoaporphines, wich are photoreduced by amines, generating ionic metastable photoproducts capable to store an appreciable fraction of the photoexcitation energy. The photoproducts, formed via a sequential transfer of electron-proton-electron, revert thermally to the original oxoisoaporphines generating amine photooxidation products. The back reaction of the metastable photoproducts allows the reuse of the system as long as amine remains in the system, to react with the regenerated oxoisoaporphine. In this work we studied the transient species involved in the photoreduction by amines of oxoisoaporphine and 5-methoxy-oxoisoaporphine; the excited triplet state of oxoisoaporphines, the radical anion formed after electron transfer and the neutral hydrogen radical, generated by proton transfer. Photoreduction intermediary transients were generated by laser flash-photolysis, in the presence and absence of tertiary amines, with and without transferable α- hydrogen. If the amine is not able to donate protons, the reaction will only proceed until the formation of A-·, allowing its characterization. With amines capables to donate an α- H, photoreduction continues to the formation of neutral hydrogen radical AH·, and eventually to metastable photoproducts. In this work triplet excited states were characterized, radical anions and neutral hydrogen radicals for both oxoisoaporphines and the kinetic parameters through evolve were also determined
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SINER, ANGELA. "In vivo metabolism of 7H-dibenzo[c.g.] carbazole (DBC) and benzo[a]pyrene (BaP)". University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1014752553.
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Ryezayeva, Natalya. "Search for the p1/2- Resonance in 7He with the 7Li(d,2He) Reaction and Measurement of the Deuteron Electrodisintegration under 180-deg at the S-DALINAC". Phd thesis, [S.l.] : [s.n.], 2006. http://elib.tu-darmstadt.de/diss/000762.
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Hatton, Christopher C. "GIS-T7F: a geographic information system-data input module for the traffic signal simulation model transyt-7F". Thesis, Georgia Institute of Technology, 1991. http://hdl.handle.net/1853/20943.
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Léon, Pascale. "Etudes de relations structure-activite dans la serie des dimeres de 7h-pyridocarbazole, agents antitumoraux bis-intercalants de l'adn". Paris 6, 1987. http://www.theses.fr/1987PA066487.
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Léon, Pascale. "Etudes de relations structure-activité dans la série des dimères de 7H-pyridocarbazole, agents antitumoraux bis-intercalants de l'ADN". Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37607324w.
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Güllük, Eduard. "Synthese von Cyclopenta[c]pyran-3(5H)-on und Cyclopenta[c]pyran-3(7H)-on als Vorstufen von Cyclopenta[c]pyranen". [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969694067.
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Booyse, Mariska. "The utilisation of assessed losses by mining companies : critical analysis of the armgold/harmony freegold judgment". Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/41253.
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The method of taking into account assessed losses in calculating the taxable income of
mining companies is of significant importance following the Armgold/Harmony Freegold
case. In this case, the court had to determine the method of calculating a mining
company’s taxable income where at least one of its mines incurred a loss and where nonmining
income was also derived. What constitutes an assessed loss, and the order in
which it should be applied in calculating a mining company’s taxable income, was central
to this case. In this study, the different approaches adopted by the parties to the case in
order to determine whether there is an assessed loss, and the order in which it should be
utilised in calculating taxable income, was analysed and compared to an analysis of the
provisions of the Income Tax Act. In terms of this comparison, the judgment was found to
be in accordance with the current legislation in the Income Tax Act. There is, however, a
lack of updated guidance on matters relating to mining tax as is evident from the different
interpretations of the provisions of the Income Tax Act by the parties to the case. Further
research is therefore recommended in order to provide updated guidance to mining
companies.Dissertation (MCom)--University of Pretoria, 2013.
am2014
Taxation
unrestricted
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Eikenbusch, Annika [Verfasser], Ute [Akademischer Betreuer] Felbor, Ute [Gutachter] Felbor i Eva [Gutachter] Klopocki. "Wirkung der mikroRNAs miR-30a-5p und let-7f-2-3p auf die Angiogenese in vitro durch Regulation von CCM3 / Annika Eikenbusch ; Gutachter: Ute Felbor, Eva Klopocki ; Betreuer: Ute Felbor". Greifswald : Universität Greifswald, 2021. http://d-nb.info/1233428365/34.
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Kim, Dong Yoon. "Nikάw as an over-arching motif in Revelation". Thesis, University of St Andrews, 2009. http://hdl.handle.net/10023/1969.
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This study has attempted to show the overarching significance of the conquering motif in relation to discourse dynamics of the entire book of Revelation and the significance of salvific history for its syntagmatic understanding. Based on language-in-use as a whole between the model author and the model audience, syntagmatic analysis (i.e., SVU analysis) and associative analysis (i.e., sign-intertextual reading) are eclectically and concertedly utilized by means of sampling analysis. Utilizing this integrative method, the findings are as follows: (1) the interwoven network of the prologue (Rev 1:1-8) programmatically provides the paradigmatic reading strategy for understanding the key paraenetic motif in the rest of the book against the background of salvific history; (2) by summarizing the churches’ earthly prophetic roles – withdrawal and witness through martyrdom – in terms of conquering, the model author alerts his audience to the military significance of their daily actions or choices in their ordinary earthly lives through visionary communication; (3) just as the prologue preliminarily guides, the ever-forward-moving historical framework serves as an incentive device for the paraenetic-imperative in Rev 2-3 and 4-22.
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DEMONCHY, Charles-Edouard. "étude de réactions et d'états isobariques analogues dans le système 8He+p, à basse énergie, à l'aide de la cible active MAYA". Phd thesis, Université de Caen, 2003. http://tel.archives-ouvertes.fr/tel-00004117.
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Les dévellopements récents des faisceaux exotiques, et en particulier avec le dispositif SPIRAL du GANIL, nous ont permis d'initier l'étude, dans l'9He, de l'inversion de couches déjà observée dans les isotone N=7, pour le 11Be et le 10Li. Une partie du travail est consacré à l'étude et au développement d'un détecteur servant aussi de cible (cible active) appelé MAYA, ainsi qu'au développement des outils informatiques nécessaires à son exploitation. l'9He a été étudier par la détermination des propriétés de ses états isobariques analogues (IAS) dans le 9Li. Les caractéristiques de ces états IAS sont obtenues par l'analyse des résonances dans les sections efficaces de diffusion élastique, du système 8He+p entre 2 et 3.9 MeV/n. Une étude rapide des réaction (p,d) et (p,t) est aussi présenté. Cette étude a permis, par la comparaison des résultats expérimentaux et des calculs de diffusion potentielle avec résonances, une assignation de spin et parité pour deux états de l'9He.
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Pathak, Sanmoy. "Immunomodulatory effects of 7-hydroxy frullanolide, a plant-based sesquiterpene lactone, in inhibiting immune cell responses and roles of disease and vaccination outcomes on Covid-19 mortality". Thesis, 2020. https://etd.iisc.ac.in/handle/2005/4873.
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Immunomodulation is a process by which the immune response of the host is either enhanced or
suppressed due to various factors which either protects or makes the host more susceptible to
particular diseases. Immunomodulators are a broad class of drugs that are used either to suppress
(immunosuppressants) or enhance (immunostimulants) immune responses. These have been used
to combat against the dysregulated immune system, observed during tissue/organ transplantation
and disorders such as rheumatoid arthritis, ulcerative colitis and cancer.
Plant-based immunomodulators such as capsaicin, curcumin and resveratrol are extensively used
as immunomodulators and anti-inflammatory drugs. Sesquiterpene lactones are a major class of
plant-based immunomodulators that are derivatives of sesquiterpenoids and are obtained from
Asteraceae. These molecules are known for its anti-inflammatory and anti-tumor effects. The
objective of my first study was to understand the roles of 7-hydroxy frullanolide (7HF) on different
immune cells and to decipher the underlying mechanisms of action. Primary CD4+ T cells were
isolated from lymph nodes of C57BL/6 mice, followed by treatment with different doses of 7HF
and in-vitro activation with plate bound (pb) αCD3 and soluble αCD28. 7HF in a dose dependent
manner caused a reduction in IL2 production and inhibition of upregulation of CD69, an early
activation marker in CD4+ T cells. Subsequently, it was also observed that 7HF abrogated the
increase in cell size and cellular proliferation with T cell activation. Ca2+
-dependent signaling pathways are an indispensable part of CD4+ T cell activation and overall T cell responses; hence it
was important to understand whether 7HF had any effects on Ca2+ levels. Surprisingly, 7HF
increased intracellular Ca2+ levels, more than optimal levels, during CD4+ T cell activation at early
timepoints. We functionally confirmed this observation using a specific intracellular Ca2+ chelator,
BAPTA-AM which rescued cellular proliferation with 7HF treatment during CD4+ T cell
activation. To understand how 7HF caused a significant increase in intracelullar Ca2+ amounts, we
performed Ca2+ channel inhibitor studies to understand whether 7HF behaved as a Ca2+ channel
agonist in CD4+ T cells. Additionally, 7HF also caused a significant increase in extracellular lactate
amounts which was functionally confirmed using 2-Deoxy D-glucose (2DG) experiments
suggesting that 7HF was working on multiple fronts to hinder T cell responses. Subsequently, we
tried to understand whether there was a link between increased Ca2+ levels and lactate levels during
CD4+ T cell activation. Finally, to understand whether there is a link between Ca2+ and lactate,
experiments were done using BAPTA-AM that confirmed Ca2+ levels did regulate lactate levels
during CD4+ T cell activation. Next, we tried to understand the effect 7HF had on other immune cells. Although 7HF had no
effect on lipopolysaccharide (LPS) stimulated splenocytes which primarily activates B cells, 7HF
did inhibit activation of LPS treated adherent peritoneal macrophages with respect to nitrite and
IL6 amounts in a dose dependent manner. Furthermore, 7HF inhibited peritoneal macrophage
activation via a Ca2+ dependent mechanism. Ca2+ channel inhibitor studies also suggested that 7HF
was behaving as a Ca2+ channel agonist in peritoneal macrophages, similar to CD4+ T cells.
However, 7HF had no effect on lactate levels in peritoneal macrophages as compared to CD4+ T
cells. Lastly, we wanted to identify the molecular mechanisms by which 7HF was acting as a Ca2+
agonist. Thus, we performed autodocking experiments using the autodock modelling simulation
software and standardized the binding of 7HF to Ca2+ channels. We initially obtained the crystal
structure of the Ca2+ channel proteins, IP3R and TRPV1 and tried to dock the 3D structure of the
ligands into the respective pockets of the protein molecules. We observed that 7HF was binding
to both TRPV1 and IP3R Ca2+ channels with a significant binding energy when compared to the
positive controls. Hence it is likely that 7HF behaved as a Ca2+ channel agonist to greatly increase
Ca2+ amounts that inhibited both T cell and macrophage responses.
To understand the physiological relevance of 7HF, we performed in-vivo experiments with 7HF
using the Dextran sulfate sodium (DSS) induced colitis model of mice which is an animal model
of autoimmune Inflammatory Bowel Disease. We used the golden standard of estimating the
severity of colitis by measuring the colon length. DSS, as reported, caused a severe shortening of
colon length which was rescued by 7HF in a dose dependent manner. The extent of colon damage
as observed due to severe damage in the crypts and extensive immune cell infiltration by DSS was
significantly reduced by 7HF. Also, 7HF rescued the loss in thymocyte and mesenteric lymph node
(MLN) cell numbers due to DSS treatment. Finally, 7HF significantly reduced the amounts of
proinflammatory cytokines, IFNγ and IL6 in the sera. Overall, this study clearly demonstrates the
in-vivo effects of 7HF as an anti-inflammatory molecule. Both in-vitro and in-vivo studies together
strengthen the observation that 7HF may have potential therapeutic applications to treat different
autoimmune disorders.
My next study was performed during the Covid-19 pandemic. An epidemiological study was
performed during the months of April-June 2020 to understand the effects of pathogen exposure
and vaccination coverage on Covid-19-induced mortality. Covid-19 deaths display a high
heterogeneity across different countries and the extent of infection in a particular population might
be dependent on multiple factors such as age, sex, temperature, humidity etc. This led us to perform
correlation studies with 36 (out of 215) countries having more than 1000 Covid-19 deaths as of
24th June 2020. The major observations of this study are: measles, HBV and polio vaccination
coverage had no correlation with Covid-19 incidences and deaths. Subsequently, flu incidences
had no correlation with respect to Covid-19 incidences and deaths. However, flu deaths showed a
significant negative correlation with Covid-19 mortality rate and Covid-19 deaths/million.
Additionally, flu vaccination had a significant positive correlation with Covid-19 incidences,
Covid-19 deaths, mortality rate and Covid-19 deaths/million. Next, Tuberculosis (TB) only
negatively correlated with Covid-19 mortality rate and Covid-19 deaths/million. This trend was
also holding for TB deaths. Similarly, Bacillus Calmette Guerin (BCG) coverage had a significant
negative correlation with Covid-19 deaths, mortality rate and Covid-19 deaths/million suggesting
its protective role. Interestingly, countries which have flu, but no BCG, vaccination show highest
number of Covid-19 deaths. Countries that have high flu and BCG vaccinations demonstrate more
immunomodulatory effects in determining the fate of a particular disease and its effects on the
host.
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Tang, Kai-Ping, i 唐開平. "The Spectroscopic Studies of the Proton-Electron Coupled Reaction of the excited 7-Hydroxyquinoline(7HQ)". Thesis, 1996. http://ndltd.ncl.edu.tw/handle/88378261339189256236.
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碩士輔仁大學
化學系
84
The fluorescence molecule 7-hydroxyquinoline(7HQ) can conform the H-bondingcomplexes with the acetic acid and lactam molecules in the high temperature(48degree of Celsius temperature) cyclohexane solution1.We'll compare the differenceof their absorption and emission spectra. In the high temperature environment,7HQ will conform 1:1 stabilized cyclic complexes with acetic acid molecules.After excited,the cyclic 1:1 7HQ-acetatecomplexes will emmit the light which has the max. intensity at 530nm wavelength. In the same conditions, the lactam molecules won't conform a cyclic complexes withthe 7HQ from UV absorption obtained.Thus,we can't observe the tutomer band at520~540 nm wavelength. In order to check this result,we add individually NH(Et)2,cyclohexanone,EA to the 7HQ/ cyclohexane solution.We found only the solution added NH(Et)2 has the same change with added lactam(I) on the observed absorption spectra.Therefore,we concluded that 7HQ conform a silgle-side H-bonding with the lactam(I) molecule,due to the functional group ≧N has more stronger bacisity than the acidity of -OH group on 7HQ to form a 1:1 nom-cyclic H-bonding complexes.
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Huang, Yu-Chun, i 黃煜珺. "Investigation of the inhibitory action mechanisms of 7HQ and several synthetic chemical compounds on nitric oxide production in murine macrophage RAW 264.7 cells". Thesis, 1999. http://ndltd.ncl.edu.tw/handle/70723819600655819873.
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碩士國立臺灣大學
藥理學研究所
87
Nitric oxide (NO) is an important biological mediator associated with multiple pathophysiological phenomena, such as platelet aggregation, vasodilatation, septic shock, and autoimmune diseases. In addition, NO is also of great benefit in homeostasis. However, excessive production of NO may cause detrimental effects. The active component of endotoxin, lipopolysaccharide (LPS), promotes NO production in inflammatory states. In this study, we demonstrated the effects of several synthetic chemical compounds, such as 7HQ derivatives, DCDC and DHNC on LPS-induced NO formation in murine RAW 264.7 cells, a macrophage-like cell line. LPS significantly induced iNOS expression and nitrite production in RAW 264.7 cells. Pre-incubated with the above compounds, the iNOS expression and nitrite accumulation by LPS were inhibited in a dose-dependent manner. However, the direct iNOS activity was only slightly affected by these compounds. Thus, the relationship between iNOS activity and NO formation was not very relevant. NF-kB, a transcription factor, served as a key point in the modulation of iNOS gene expression. In unstimulated cells, it located in the cytoplasma and associated with an inhibitory protein, IkB. After activation, NF-kB translocated into the nucleus and initiated the gene transcription. According to our electrophoretic mobility shift assay (EMSA) results, we have demonstrated that these synthetic chemical compounds could efficiently inhibit the activation of NF-kB by preventing its translocation. Furthermore, reactive oxygen species may involve in the activation of NF-kB. Analysis by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) scavenging test, we found that DCDC and DHNC were powerful as free radical scavengers. We have also determined the effects of these compounds on COX-2 activity and found that DCDC exerted a profoundly inhibitory effect on this enzyme activity. These results suggest that these synthetic chemical compounds exhibit inhibitory effects on LPS-induced NO production by decreasing iNOS expression through inhibition of IkB-a degradation and NF-kB activation.
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Monteiro, Maria Alexandre de Sá. "Relatório de Estágio Pedagógico desenvolvido na Escola Básica Integrada c/ JI Prof. Dr. Ferrer Correia, junto da turma 7ºF no ano letivo 2016/2017". Master's thesis, 2017. http://hdl.handle.net/10316/84025.
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Relatório de Estágio do Mestrado em Ensino de Educação Física nos Ensinos Básico e Secundário apresentado à Faculdade de Ciências do Desporto e Educação FísicaO Estágio Pedagógico é, sem dúvida, um ponto fulcral na formação de um professor de Educação Física, pela sua aplicação prática de conhecimentos e pela apropriação ou desenvolvimento de competências pedagógicas de intervenção e gestão. Trata-se de um período de formação, onde são desenvolvidas competências no âmbito da ética profissional, simultaneamente com a possibilidade de exercer as funções de docente. O Relatório Final de Estágio insere-se no plano curricular do 2º ano do Mestrado em Ensino de Educação Física nos Ensinos Básico e Secundário, da Faculdade de Ciências do Desporto e Educação Física da Universidade de Coimbra. O presente relatório está dividido em três grandes capítulos que englobam toda a prática realizada este ano. O primeiro, trata uma contextualização da prática desenvolvida, onde são também descritas as expectativas iniciais e as dificuldades ultrapassadas. O segundo capítulo, consiste numa análise reflexiva sobre a prática pedagógica, que aborda as Atividades de Ensino-Aprendizagem, as Atividades de Organização e Gestão Escolar, as Atividades de Projeto e Parcerias Educativas e a Atitude Ético-profissional. Por fim, o terceiro capítulo é o aprofundamento de um tema-problema, um estudo comparativo sobre: “A perceção sobre a disciplina e a indisciplina nos alunos institucionalizados e não institucionalizados: conceito e fatores”. Este estudo revelou que não existem grandes diferenças na perceção entre alunos institucionalizados e não institucionalizados, no que diz respeito à conceção de disciplina e aos fatores de indisciplina.
The Teacher Training is undoubtedly a focal point in the formation of a Physical Education teacher, for his practical application of knowledge and for the appropriation or development of pedagogical skills of intervention and management. It is a period of training, where skills are developed in the scope of professional ethics, simultaneously with the possibility of exercising the functions of teacher. The Final Report of Teacher Training is included in the curricular plan of the 2nd year of the Master's Degree in Physical Education Teaching in Basic and Secondary Education, Faculty of Sports Sciences and Physical Education, University of Coimbra. This report is divided into three main chapters that cover the entire practice held this year. The first one deals with a contextualization of the developed practice, where the initial expectations and the overcome difficulties are also described. The second chapter consists of a reflexive analysis of pedagogical practice, which addresses Teaching-Learning Activities, School Organization and Management Activities, Project Activities and Educational Partnerships, and Ethical-Professional Attitude. Finally, the third chapter is the deepening of a theme-problem, a comparative study on: "Discipline and Indiscipline - Students' Perception of Conception and Factors". This study revealed that there are no big differences in the perception between institutionalized and non-institutionalized students, regarding the conception and the factors of discipline and indiscipline.
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Ferreira, Gonçalo André de Matos. "Relatório de Estágio Pedagógico Desenvolvido no Agrupamento de Escolas Martim de Freitas (EB 2,3 Ciclo de Martim de Freitas), junto da turma do 7ºF, no ano letivo 2019/2020". Master's thesis, 2020. http://hdl.handle.net/10316/96628.
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Relatório de Estágio do Mestrado em Ensino de Educação Física nos Ensinos Básico e Secundário apresentado à Faculdade de Ciências do Desporto e Educação FísicaNo âmbito do segundo ano do Mestrado em Educação Física nos Ensinos Básico e Secundário da Faculdade de Ciências do Desporto e Educação Física da Universidade de Coimbra, é esperada a realização de um Estágio Pedagógico, durante um ano letivo. Este é caraterizado pela aplicação dos conhecimentos adquiridos relativos à intervenção pedagógica, ao longo dos quatro anos de formação académica, através duma prática docente em contexto real. Assim, e de modo a relatar e a refletir sobre toda a experiência e aprendizagem vivenciada ao longo de todo o Estágio Pedagógico, desenvolvido na Escola Básica 2, 3 Martim de Freitas, no ano letivo de 2019/2020 junto da turma do 7ºF, na disciplina de Educação Física, surge o presente relatório, pertencente à Unidade Curricular de Relatório de Estágio. O supracitado documento foi dividido em três capítulos, sendo que no Capítulo I teremos a Contextualização da Prática, onde constarão as expetativas iniciais, e uma breve caraterização da escola, do grupo disciplinar, do núcleo e da turma, respetivamente. Já o Capítulo II, que estará subdividido em três áreas, será reservado à Análise Reflexiva da Prática Pedagógica, ou seja, todo o trabalho elaborado, durante o Estágio Pedagógico. Na área 1 teremos o processo de planeamento, de realização e de avaliação, não deslembrando a atitude ética-profissional, a justificação das opções tomadas e ainda as questões dilemáticas. Na área 2 apresentaremos as atividades de organização e gestão escolar e na área 3 poderemos encontrar os projetos e parcerias educativas. Por fim o último capítulo, Capítulo III, será dedicado ao aprofundamento do tema problema, intitulado de “Perceções sobre a intervenção pedagógica de diferentes atores no mesmo contexto de ensino-aprendizagem”, onde constará toda a revisão sistemática de literatura.
In the second year of the Master’s degree in Teaching of Physical Education in Basic and Secondary School in the Faculty of Sports Sciences and Physical Education of the University of Coimbra, it is required a teacher training during the academic year. This Teacher Training is characterised by the practice of the acquired knowledge about the pedagogic intervention, from four years of academic degree, in a real context. In order to describe and reflect about whole experience and learning during the Teacher Training, developed in Escola Básica 2, 3 Martim de Freitas, in the academic year of 2019/2020 with the class of 7ºF, arise the present report, as the graduation requirements of the master course.The report à priori mentioned is structured in three parts. In the “Capítulo 1”, the first chapter, where are expose the practice contextualization, will be described the initial expectations and a brief explanation about the school characterization, the group of work, the internship unit and the class. In the second chapter, that is structured in three main areas, will be explain the internship itself. In the first area, “Area 1”, will have the process of the accomplishment and evaluation planning, not forgetting the ethic-professional behaviour, the reason of some decisions and some dilemmas. In “Area 2” will be expose the organization and scholar management activities. In “Area 3” will be described some educational projects and partnership. In the last chapter, “Chapter 3”, is dedicated for the problematic theme, “Perceptions about the pedagogic intervention of the different actors in the same context of teaching-learning: a comparative study between three curricular subjects of one class of 10th year”, where will be explained the whole literature revision.
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Lin, Leu-Shiang, i 林呂相. "An Application Study of the Genetic Algorithm on a Popular Network Signal Timing Design Model─TRANSYT-7F". Thesis, 1993. http://ndltd.ncl.edu.tw/handle/54672234815503061303.
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碩士國立成功大學
交通管理(科學)學系
81
Generally speaking,the TRANSYT model is one of the most important and popular network signal timing design models in the world. It comprises a traffic flow simulation model and another signal timing optimization model.The former one is to macroscopically simulate the plotoon progression behavior in the road segment. The latter one,then,is used to find the optimal signal timing pattern. Since 1967,the traffic flow simulation model has been revised several times so that it can sa- tisfactorily interprete the real-world flow phenomena. But a so called "Hill-Climbing Method" has been employed in its timing optimization model for 25 years and can only obtain a local optimum timing solution. The Genetic Algorithm is currently developing to act as a new optimization method that can find the global optimum timing solution.Based on this understanding,a new network timing design model,i.e. TRANSYT- GA, is proposed to improve the performance of TRANSYT-7F Model which is a widely used version in the TRANSYT models family, All the important features which are derived from the Genetic Algorithm,i.e.Crossover Method、Rate of Match、 Preventing Incest、Probability of Mutation.Fitness and K value of the performance index,are carefully defined in this thesis study. For the simulation results with no-limited computation time cases,the performance improvements of TRANSYT-GA than TRANSYT-7 F are between 0.62% and 17.6% on the artificial networks. And for the actual network cases,it is betwween 3.29% and 15.61%. In the other studies of fixed-time simulation,evidances show that TRANSYT-GA is better than TRANSYT-7F around -7.25% to 16.46% in pseudo network cases and -5.87% to 9.34% in the actual network cases.
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Ryezayeva, Natalya [Verfasser]. "Search for the p1/2_1th- resonance in 7He with the 7Li(d,2He) reaction and measurement of the deuteron electrodisintegration under 180° at the S-DALINAC / angefertigt von Natalya Ryezayeva". 2006. http://d-nb.info/982490291/34.
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ZHONG, HUI-YU, i 鐘慧諭. "交通維持計畫之研究--以NINUTP與TRANSYT-7F評估工具". Thesis, 1991. http://ndltd.ncl.edu.tw/handle/78029662937827448595.
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Güllük, Eduard. "Synthese von Cyclopenta[c]pyran-3(5H)-on und Cyclopenta[c]pyran-3(7H)-on als Vorstufen von Cyclopenta[c]pyranen". Doctoral thesis, 2003. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-6759.
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Die bisher unbekannten a-Pyrone Cyclopenta[c]pyran-3(5H)-on und Cyclopenta[c]pyran-3(7H)-on wurden auf zwei unabhängigen Synthesewegen hergestellt. Die Reaktivität der neuen a-Pyrone wurde untersucht. Das Hauptaugenmerk lag dabei auf der Synthese von Cyclopenta[c]pyranenThe hitherto unkwown a-pyrones cyclopenta[c]pyran-3(5H)-one and cyclopenta[c]pyran-3(7H)-one were prepared via two independent synthetic pathways. The reactivity of the new a-pyrones was investigated. The main objective was the synthesis of cyclopenta[c]pyrans
29
Güllük, Eduard [Verfasser]. "Synthese von Cyclopenta[c]pyran-3(5H)-on und Cyclopenta[c]pyran-3(7H)-on als Vorstufen von Cyclopenta[c]pyranen / vorgelegt von Eduard Güllük". 2003. http://d-nb.info/969694067/34.
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WANG, XIAO-RU, i 王筱如. "PASSER- Ⅱ模式理論及其與MAXBAND.TRANSYT-7F 應用於幹道號誌時制設計之比較研究". Thesis, 1986. http://ndltd.ncl.edu.tw/handle/80278575619296253885.
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WANG, GUO-CAI, i 王國材. "發展新TRANSYT-7F模式以應用於國內動態電腦號誌系統時制設計之研究". Thesis, 1988. http://ndltd.ncl.edu.tw/handle/66940818664358019306.
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Mendes, Nuno Serra e. Moura Pacheco. "Relatório de estágio pedagógico desenvolvido na Escola Básica Drª Mª Alice Gouveia, junto da turma do 7ºF no ano letivo de 2016-2017 : perceções e reações dos professores a comportamentos de indisciplina de maior gravidade na Escola Básica 2-3 Drª Maria Alice Gouveia". Master's thesis, 2017. http://hdl.handle.net/10316/47676.
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Relatório de estágio do mestrado em Ensino de Educação Física nos Ensinos Básico e Secundário, apresentada à Faculdade de Ciências do Desporto e Educação Física da Universidade de Coimbra.O Relatório de Estágio é marcado pelo término de mais uma etapa académica. O presente documento é alusivo ao estágio desenvolvido na Escola Básica 2.3 Dr.ª Maria Alice Gouveia do agrupamento de escolas Coimbra Sul, junto da turma F, do 7º ano. O relatório final de estágio é pautado por uma reflexão geral e crítica do processo pedagógico desenvolvido durante o presente ano letivo (2016/2017). Este encontra-se estruturado em duas partes centrais: a primeira refere-se à contextualização da prática, à análise reflexiva sobre a prática pedagógica, à análise reflexiva das áreas curriculares integrantes do Estágio Pedagógico, e a análise reflexiva das áreas curriculares integrantes do estágio pedagógico. Já a segunda parte central do relatório, apresenta o estudo caso desenvolvido ao longo do ano letivo denominado de “Perceções e Reações dos professores a comportamentos de indisciplina de maior gravidade, na escola Básica 2/3 Dr.ª Maria Alice Gouveia”. Ao nível dos resultados do estudo de caso verificou-se que na sua maioria os professores percecionam os comportamentos de indisciplina de 3º nível como “muitos graves” e que por norma ao reagirem a estes “nunca – às vezes” o ignoram. The Teacher Training Report is marked by the end of another academic stage. This document is alluding to the Teacher Training stage carried out in the Basic School 2.3 Dr. Maria Alice Gouveia, wich is part of Coimbra Sul's School group, next to the class F of the 7th grade. The final Teacher Training Report is based on a general and critical reflection of the pedagogical process developed during the current school year (2016/2017). This document is structured in two main parts: the first refers to the contextualization of practice, reflexive analysis on pedagogical practice, reflexive analysis of the curricular areas that are part of the Teacher Training stage, and the reflexive analysis of the curricular areas that are also part of the Teacher Training stage. The second part of the report presents the case study developed during the school year called the “Perceptions and Reactions of teachers in relation to behaviors of indiscipline of greater severity, in Basic School 2/3 Drª. Maria Alice Gouveia”. Refering to the results of the case study it was verified that most teachers perceive the 3rd level behaviors of indiscipline as "very serious" and that as standard when reacting to these they "never - sometimes" ignore it.
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Shani, Saeideh. "The implication of cell-derived microvesicles in retinal pigment epithelium degeneration". Thèse, 2018. http://hdl.handle.net/1866/22150.
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34
CHEN, ZHAO-HONG, i 陳昭宏. "發展新TRANSYT-7F模式以加速程式運算之研究－配合國內動態電腦號誌之使用". Thesis, 1987. http://ndltd.ncl.edu.tw/handle/06672933085026286176.
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碩士國立成功大學
交通管理(科學)研究所
75
TRANSYT-７F 是目前被應用最廣泛的號制設計套裝程式，此程式在國內測試尚能處理 國內的交通狀況，意謂具有相當程度的適用性。但由於此程式之執行時間頗為冗長， 使用個人電腦不方便，所以本論文的目的在於改良TRANSYT-７F 模式求取最佳時制的 過程，以期降低TRANSYT-７F 設計最佳號誌時制的電腦執行時間，使其在未來可用於 離線分析或即將設立的動態電腦號誌系統。 本研究主要重點在於以收斂較快速的Fibonacci 尋優法，取代原TRANSYT-７F 於週期 最佳化過程中，所採用的爬山尋優法，根據實例驗證，證明效果良好，大約可減少３ ０％的個人電腦執行時間。 此外，由於國內大都市（如台北市）人口擁擠及一些舊市區（如台南市），街廓的距 離很短，在交通量遞增的今日，很容易造成路口溢流（Spillover ）的現象。而TRA- NSYT-７F模式並未對此方面加以探討。因此本論文也將溢然現象加入TRANSYT-７F 模 式的績效指標（Pertormance Index，PI ）中，做為目標函數的一部份，籍著負效用 影響以期避免或降低路口溢流現象的產生，使該程式能更適用於國內使用。 ＃１０１１５２２Ｐ ＃１０１１５２２Ｐ
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Wu, Rang-rong, i 吳瑞蓉. "Synthesis Study and Bioactivity Evaluation of 6-Amino-3-substituted-1,2,4-triazolo[3,4-f][1,2,4] triazin-8(7H)-ones and 5-Amino-3-aryl-1,2,4- triazolo[4,3-d][1,2,4]triazines". Thesis, 2002. http://ndltd.ncl.edu.tw/handle/52010180459295410947.
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碩士高雄醫學大學
藥學研究所
90
英 文 摘 要 This study has synthesized two series of bicycloheterocyclic derivatives, 3-substituted-6-amino-1,2,4-triazolo[3,4-f][1,2,4]triazin-8(7H)- ones and 5-amino-3-aryl-1,2,4-triazolo[4,3-d][1,2,4]triazines. The former includes 3-alkyl-, 3-aryl-, 3-alkylamino-, 3-arylamino- and 3-alkylsulfanyl-6-amino-1,2,4-trizolo[3,4-f][1,2,4]triazin-8(7H)-ones. The later is 3-alkyl-5-amino- and 5-amino-3-aryl-1,2,4-triazolo[4,3-d][1,2,4] triazines. We have obtained nineteen bicycloheterocyclic compounds in five types from both series. The monocycloheterocyclic 3-amino-6-hydrazino-1,2,4-triazin-5(2H)- one(4) reacted with acyl chlorides via nucleophilic substitution would afford 6-acylhydrazino (6-NHNHCOR) substituted compounds. Compound 4 condensed with aldehydes would gain 6-methylidenehydrazino (6-NHN=CHR) substituted compounds. Compound 4 underwent nucleophilic addition reaction with isothiocynates could give 6-(4-N-substitutedthiosemicarbazido) (6-NHNHCSNHR) substituted derivatives. We explored new processes to gain bicycloheterocyclic derivatives through different reaction modes of cyclization of above monocycloheterocyclic substituted compounds. The new processes to synthesize 3-alkyl-6-amino- and 6-amino-3-aryl-1,2,4-triazolo[3,4-f][1,2,4]triazin-8(7H)-ones included (1) the sililated cyclization of 6-acylhydrazino substituted compounds, a rather convenient way to acquire high yield rate as well as purity of the products, (2) the nucleophilic substitution and then cyclization of 3-amino-6-bromo-1,2,4-triazin-5(2H)-one with acylhydrazines refluxed under DMSO solvent, which was an one-step reaction, (3) the cyclization of 6-methylenehydrazino substituted compounds catalyzed by Pb(OAc)4 or Br2/FeCl3, with products via Pb(OAc)4 being easier to purify and higher yield. The mechanisms of above reactions will also be proposed. 3-Alkylamino-6-amino- and 6-amino-3-arylamino-1,2,4-triazolo- [3,4-f][1,2,4]triazin-8(7H)-ones could not be gained by cyclization of 6-(4-N-substitutedthiosemicarbazido) substituted derivatives; howerer, they could be obtained by nucleophilic aromatic substitution of sililated intermediate of 6-amino-3-thio(2H)-1,2,4-trizolo[3,4-f][1,2,4]triazin- 8(7H)-one reacted with alkylamine or arylamine. 6-Amino-3-alkylsulfanyl-1,2,4-triazolo[3,4-f][1,2,4]triazin-8(7H)-ones was obtained through nucleophilic substitution of 6-amino-3-thio(2H)-1,2,4-triazolo[3,4-f][1,2,4]triazin-8(7H)-one reacted with alkylbromide under methanoic ammonium. On the other hand, 5-amino-3-aryl-1,2,4-triazolo[4,3-d][1,2,4]triazines was successfully gained by sililated cyclization of 3-amino-5-acylhydrazino-1,2,4-triazines. The synthesized products of monocycles and bicycloheterocycles in this study were tested on the bioactivity of anti-cancer properties against colon cancer SW480、COLO205 and human lung cancer cells H520. Compound 31 showed potent cytotoxicity(39%) against H520. Compounds 25, 38, 39, 49, 50 and 52 were evaluated on the inhibition of purine nucleoside phosphorylase (PNP), with 39, 49 and 52 owing the better inhibitory effects.
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簡心怡. "3-取代基-1H-[1,2,4]三[5,6-e][1,2,4]—二6(5H)-酮及3-取代基-1,2,4-三唑[3,4-f][1,2,4]三氮肼-6(5H),8(7H)-二酮衍生化合物之合成研究及生物活性測試". Thesis, 2003. http://ndltd.ncl.edu.tw/handle/79268962064013210403.
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