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Charles-Edwards, Thomas. "A dictionary of Irish saints. By Pádraig Ó Riain. Pp 660. Dublin: Four Courts Press. 2011. €65." Irish Historical Studies 38, nr 150 (listopad 2012): 337–38. http://dx.doi.org/10.1017/s0021121400001188.
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Kruglova, Larisa S., Sergey I. Surkichin, Natalya V. Griazeva, Lyudmila Sergeevna Kholupova i Roman Yuryevich Mayorov. "Evaluation of the effectiveness and safety of photodynamic skin therapy". Russian Journal of Skin and Venereal Diseases 24, nr 2 (3.09.2021): 187–96. http://dx.doi.org/10.17816/dv62719.
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BACKGROUND: Photodynamic therapy is an innovative technique for non-invasive skin rejuvenation by stimulating neocollagenogenesis.
AIMS: The aim of our study was to assess the safety and efficacy of photodynamic therapy on the skin using a wavelength of 660 nm, as a photosensitizer (PS) Spherometallochlorin.
MATERIALS AND METHODS: The study was divided into 2 stages. The first stage of the study involved 5 female laboratory rats. The first stage was divided into 2 substages: 1A the oral mucosa of 5 rats were irradiated for 30 minutes with 5 wavelengths of 660 nm (energy 100 J/cm2, power 100 mW/cm2). 1B FS Spherometallochlorin was applied to the skin of the back of rats after preliminary shaving in the form of 0.4% gel. Before applying the topical agent, after 15 minutes of exposure, after 30 minutes of exposure, after 45 minutes of exposure, in order to assess the penetration of the PS, a punch biopsy was taken in the area of application of the gel. The second stage of the study involved 15 female volunteers aged 21 to 65 years. At stage 2A, the skin behind the ear of 5 women was irradiated for 30 minutes at a wavelength of 660 nm (energy 100 J/cm2, power 100 mW/cm2) using a PS 0.4% gel containing Spherometallochlorin. Stage 2B evaluated the effectiveness of the effect of PDT procedures on the skin of 15 women. Skin condition was assessed using cutometry, corneometry, measurement of transepidermal water loss, and punch biopsy samples of the parotid skin (before and after the course of procedures), photographing and assessment of unwanted effects were also carried out.
RESULTS: The histological picture before and after the study was similar. The preparation usually contained small fragments of the oral mucosa. The superficial squamous non-keratinizing epithelium was of normal morphology. On the surface of some fragments, hemorrhages (artifact of material sampling) were present. No inflammation, edema or hyperemia was observed in the underlying mucosa. Thus, no signs of inflammation or burns were found.
CONCLUSION: The used radiation with a wavelength of 660 nm is completely safe, does not cause pathological changes in the skin. The course of PDT procedures is a safe, effective method causing remodeling of the dermis. PDT using 660 nm radiation and Spherometallochlorin as a PS can be recommended for use in practical health care.
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Imran Firman i Sartika. "Studi Tingkat Penggunaan Antibiotik Untuk Pasien ISPA Di Instalasi Rawat Jalan BBKPM Makassar Periode Oktober – Desember 2017". INHEALTH : INDONESIAN HEALTH JOURNAL 1, nr 1 (7.02.2022): 1–10. http://dx.doi.org/10.56314/inhealth.v1i1.17.
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Telah dilakukan penelitian tentang studi tingkat penggunaan antibiotik untuk pasien ISPA di instalasi rawat jalan BBKPM makassar. Tujuan penelitian ini adalah untuk mengetahui tingkat penggunaan antibiotik pada pasien ISPA di BBKPM makassar, berdasarkan jumlah kasus ISPA, jumlah pasien ISPA yang menggunakan antibiotik berdasarkan jenis kelamin, jumlah pasien ISPA yang menggunakan antibiotik berdasarkan usia, tingkat ketepatan penggunaan obat, tingkat penggunaan antibiotik dengan usia dari 16-71 tahun. Penelitian ini dilakukan dengan metode deskriptif dengan menggunakan data sekunder. Data sekunder yang dimaksud disini adalah semua data rekam medik dan resep pasien ISPA di instalasi rawat jalan pada bulan oktober-desember 2017. Hasil penelitian ini jumlah kasus ISPA di BBKPM makassar bulan oktober-desember 2017 adalah sebanyak 64 pasien, berdasrkan jenis kelamin yaitu laki-laki dengan jumlah 34 (53.125%) perempuan dengan jumlah 30 pasien (46.875%). Penggunaan antibiotik ISPA berdasarkan usia yaitu usia 12-16 tahun sebanyak 1 pasien (1.56%), 17-25 tahun sebanyak 13 pasien (20.31%), 26-35 tahun 10 pasien (15.63%), 36-45 tahun 14 pasien (21.88%), 46-55 tahun 12 pasien (18.75%), 56-65 tahun 9 pasien (14.06%), 65 tahun - sampai ke atas 5 pasien (7.81%). Tingkat penggunaan antibiotik yang banyak digunakan adalah Cefixime 660 (91.03%) kapsul, Eritromisin 65 (8.96%) tablet.
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Rivera Medrano, José Luis. "Influencia del Programa Pensión 65 en el bienestar de los usuarios en la Provincia de Chupaca 2020 – 2021". Socialium 7, nr 1 (5.01.2023): 56–69. http://dx.doi.org/10.26490/uncp.sl.2023.7.1.1724.
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El Objetivo de la investigación fue determinar de qué manera influye el Programa Pensión 65 en la calidad de vida de los usuarios de la provincia de Chupaca 2020 – 2021. El diseño de la investigación fue no experimental porque no se manipulará variables. Siendo un estudio descriptivo, con corte transversal se realizó en un tiempo determinado (2020-2021). La población que estudiamos estuvo compuesta por 1638 usuarios y una muestra de 287 usuarios por criterio de exclusión e inclusión. Utilizamos la encuesta como técnica luego dos instrumentos, dos cuestionarios: primero con contestación dicotómica para Programa P65, segundo cuestionario con escala de varias contestaciones politómica para calidad de vida. Validamos nuestro instrumento por juicio de Expertos, para analizar nuestra relación de variables aplicamos el coeficiente de Rho de Spearman = .050. En nuestros resultados llegamos a la conclusión, que la variable Pensión 65 influye en el bienestar de vida a través de la seguridad económica en los usuarios pertenecientes a la provincia de Chupaca – Junín 2020 - 2021 se presenta que el grado de significatividad, p <0.05 y coeficiente Rho de Spearman = .660 con una varianza del Programa P65 y bienestar de vida con una influencia en 0,01 %.
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Yu, Hui, Kee Sam Shin, Ji Ling Dong, Dae Hwang Yoo, Woong Lee, Hee Dae Im, Woong Kil i Won Jung Jung. "Microstructural Evolution and Resulting Mechanical Properties of Weld Joints upon Flux Cored Arc Welding and Post-Weld Heat Treatment". Defect and Diffusion Forum 283-286 (marzec 2009): 439–46. http://dx.doi.org/10.4028/www.scientific.net/ddf.283-286.439.
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The objective of this study is to determine the mechanism of the dramatic increase of impact toughness at low temperatures after post-weld heat treatment on weld joints. In this study, weld joints using two semi-automatic welding consumables were fabricated by flux cored arc welding with subsequent PWHT at 660°C for 65 min and 195 min, respectively. Tests of the tensile and yield strength, microhardness and impact toughness, were carried out. The microstructure was inspected by optical, scanning electron, and transmission electron microscopy in addition to compositional analysis using energy dispersive spectrometry. PWHT was observed to result in grain coarsening, sub-grain structure formation and decrease of the dislocation density. The increase of impact toughness is attributed to the relieved thermal stress, the inclusions and precipitations, softening of the structure, dislocation recovery and sub-grain structure.
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Zhang, Y., i Z. N. Zhang. "Two new species of the genus Elzalia (Nematoda: Monhysterida: Xyalidae) from the Yellow Sea, China". Journal of the Marine Biological Association of the United Kingdom 86, nr 5 (25.08.2006): 1047–56. http://dx.doi.org/10.1017/s0025315406014020.
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Two new species of free-living marine nematodes of the genus Elzalia, Elzalia gerlachi sp. nov. and Elzalia striatitenuis sp. nov. from the Yellow Sea, China, are described and illustrated. Elzalia gerlachi sp. nov. is characterized by relatively large body length (1540–1740 μm in males; 1510–1780 μm in females), spicules 135–160 μm (3.33–3.90 anal body diameter) and complex gubernaculum. Elzalia striatitenuis sp. nov. is characterized by rather small body size (560–660 μm in males; 570–630 μm in females), short cephalic setae 2.5 μm long (21.4–31.3% of head diameter), spicules 65–85 μm (4.06–4.67 anal body diameter) and relatively simple gubernaculum. The two new species can be distinguished from other species of the genus by length and structure of spicules and gubernaculum. Pictorial and tabular keys to the genus are given.
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Sitanggang, Ruly. "ANALISA UKURAN DAN LAJU ALIR BATUBARA PADA BOILER PULVERIZER PLTU 660 MW". Jurnal Technopreneur (JTech) 9, nr 2 (26.11.2021): 90–97. http://dx.doi.org/10.30869/jtech.v9i2.769.
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Pulverizer adalah salah satu peralatan penting di pembangkit listrik tenaga uap. Partikel batubara yang masih terbakar di area backpass boiler akan mengakibatkan penurunan efisiensi sehingga laju aliran campuran udara dan batubara di saluran pipa bahan bakar perlu diseimbangkan. Penelitian ini dilakukan pada PLTU Batubara tipe pulverized coal dengan kapasitas 660 Mega Watt yang menggunakan enam pulverizer. Aliran keseimbangan bahan bakar diperiksa menggunakan uji dirty air dan pengambilan sampel ukuran batubara dilakukan dengan metode isokinetik. Dalam pengujian dirty air tiga pulverizer masih mengalami turbulensi, menyebabkan pengukuran kecepatan udara menjadi kurang akurat dan hasil pengujian dirty air pada tiga pulverizer lainnya menunjukkan hasil baik dengan kecepatan antar pipa batubara seragam. Lokasi tap test pada pulverizer D, C, dan A disarankan dipindahkan ke jarak sekitar lima kali diameter pipa dari hambatan. Temperatur keluaran seluruh pulverizer pada masih lebih rendah dari nilai standard. Karena tidak ada orifice di dalam pipa batubara, menaikkan suhu keluaran pulverizer ke 65 oC dapat dilakukan untuk meningkatkan keseimbangan kecepatan batubara. Secara keseluruhan, pengujian kehalusan sampel batubara menunjukkan hasil sesuai rekomendasi, dengan nilai kehalusan rata-rata lolos saringan 200 mesh pulverizer A, B, C, D, E, dan F masing-masing adalah 82,12, 83,24, 73,96, 79,13, 68,14, dan 78,43% berat.
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Manes, Gianpiero, Paolo Andreozzi, Barbara Omazzi, Cristina Bezzio, Davide Redaelli, Massimo Devani, Daniela Morganti i in. "Efficacy of withdrawal time monitoring in adenoma detection with or without the aid of a full-spectrum scope". Endoscopy International Open 07, nr 09 (29.08.2019): E1135—E1142. http://dx.doi.org/10.1055/a-0854-3946.
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Abstract Background and study aims Withdrawal time (WT) monitoring and full-spectrum endoscopy (FUSE) have been suggested to increase adenoma detection rate (ADR) due to more accurate evaluation of the hidden areas of the colon. We aimed to evaluate the efficacy of WT monitoring and FUSE on ADR. Patients and methods This was a prospective observational study involving consecutive outpatients, aged 18 to 85 years, undergoing colonoscopy with unselected indications. In phase 1, endoscopists performed 660 colonoscopies either with standard forward-viewing endoscope (SFVE) (n = 330) or with FUSE (n = 330). In this phase, WTs were measured without endoscopist awareness of being monitored. In phase 2, endoscopists were informed of being monitored and performed additional 660 colonoscopies either with SFVE (n = 330) or with FUSE (n = 330). Results WT was lower in phase 1 compared to phase 2 (SFVE: 269 ± 83 vs. 386 ± 60 sec, P < 0.001; FUSE: 289 ± 97 vs. 403 ± 65 sec, P < 0.001). Use of FUSE increased ADR both in phase 1 (33.0 % vs. 27.3 %, P = 0.127) and in phase 2 (41.8 % vs. 33.6 %, P = 0.037). When endoscopists were aware of being monitored, ADR was higher in SFVE (33.6 % vs. 27.3 %; P = 0.090) and FUSE arms (41.8 % vs. 33.0 %; P = 0.024). Improvement in detection of proximal adenomas was associated with WT monitoring [OR 1.577 (95 % C. I. 1.158 – 2.148); P = 0.004], whereas detection of distal adenomas was associated with use of FUSE [OR 1.320 (95 % C. I. 1.022 – 1.705); P = 0.037]. Conclusions Unmonitored endoscopists have suboptimal WT, which increases when they are monitored. WT monitoring and use of FUSE are two reliable and alternative strategies to increase ADR.
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Ruhama, Ridha Siti, Febrina Mahmudah i Yurika Sastyarina. "Karakteristik Pasien Terkonfirmasi Coronavirus disease (COVID-19) di RS X Samarinda Periode Maret-Desember 2020". Proceeding of Mulawarman Pharmaceuticals Conferences 14 (31.12.2021): 262–66. http://dx.doi.org/10.25026/mpc.v14i1.582.
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Coronavirus disease (COVID-19) is a virus that has become a world pandemic including Indonesia. East Kalimantan is a province with a total of 71,092 confirmed cases of covid-19 as of March 28, 2020. The RS X Samarinda has 660 confirmed cases covid-19 during march - December period in 2020. This research aims to identify characteristics of patients covid-19 at RS X Samarinda in March - December 2020. This research is descriptive by retrospective methods. Data collection is conducted quantitatively with a sampling technique. Research instruments are 100 data inclusions of patient medical records. The results of this research show that the dominant 51% are male and 49% are female. The most age groups 34% in the early aged (46-55 years old), with further treatments >7 days as much as 65%. Patients who have 31% komorbides and without comorbidity as much as 69% in the category 87.09% diabetes mellitus. Patients data of 58,82% experienced one of the clinical symptoms of coughing/sniffles/throat pain.
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Tkach, Erin, Ammie White, Kevin Dysart, Brenda Waber, Ursula Nawab, Huayan Zhang i Erik Jensen. "Comparison of Intact Parathyroid Hormone, Alkaline Phosphatase, Phosphate Levels for Diagnosing Severe Metabolic Bone Disease in Infants with Severe Bronchopulmonary Dysplasia". American Journal of Perinatology 34, nr 12 (21.04.2017): 1199–204. http://dx.doi.org/10.1055/s-0037-1602419.
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Objective We compared the accuracy of serum intact parathyroid hormone (iPTH), alkaline phosphatase (ALP), and phosphate (phos) levels for diagnosing severe metabolic bone disease (MBD) in very low-birth-weight (VLBW) infants with severe bronchopulmonary dysplasia (BPD). Study Design Retrospective analysis of VLBW infants with severe BPD admitted between 2010 and 2012 and with ≥ 1 iPTH, ALP, and phos level collected within a similar 72-hour period. MBD severity was classified by serial radiography. Results Laboratory values were available for 65 infants, of whom 24 (36.9%) developed severe MBD. A maximum ALP > 660 IU/L was the most accurate for diagnosing severe MBD (area under the curve: 88.4%; 95% confidence interval [CI]: 77.2–94.5%). Maximum iPTH was the least accurate (optimal cut point > 130 pg/mL; area under the curve: 70.5%; 95% CI: 58.2–81.4). Conclusion Maximum ALP was more accurate than iPTH or phos for diagnosing severe MBD among preterm infants with severe BPD.
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Noh, Chang-Kyun, Hyun-Yeop Lee, Ho-Jin Kang, Seong-Tae Kim, Ho-Seon Park i Young-Jin Kim. "CMOS Wideband Low-Pass Filter Using Complementary Structured OPAMP for Wideband System Applications". Journal of Electromagnetic Engineering and Science 23, nr 1 (31.01.2023): 27–37. http://dx.doi.org/10.26866/jees.2023.1.r.141.
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In this paper, a CMOS wideband low-pass filter is proposed. In the wide band active filter design, the unit gain frequency (GBW) of OPAMP should be larger than GHz. The GBW of the proposed OPAMP is around 2.3 GHz. Additionally, the OPAMP with a complementary structure in signal and common mode feedback is proposed and has a wide operating voltage range at the input and output. The 1-dB gain compression point (P1dB) at the output is 4.9 dBm. A source follower is employed for driving 50 Ω output impedance without degrading the bandwidth and linearity of the filter. The power consumption is 27 mW from a 1-V supply voltage. The 3 dB bandwidth of the filter ranges from 330 MHz to 660 MHz with 3-bit cap tuning. This work is implemented in a 65-nm CMOS process, with a chip area of 0.18 mm<sup>2</sup>.
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Braihi, A. J., A. J. Jawad, A. A. H. Kadhum, H. S. S. Aljibori i A. A. Al-Amiery. "Chemical resistance of NR/SBR rubber blends for surfaces corrosion protection of metallic tanks in petrochemical industries". Koroze a ochrana materialu 64, nr 2 (1.06.2020): 65–71. http://dx.doi.org/10.2478/kom-2020-0010.
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AbstractIn this work, a series of Natural Rubber (NR)/Styrene Butadiene Rubber (SBR) blends were formulated to protect metallic petrochemical storage tanks from corrosive media. Therefore, these blends tested against a 10% HCl solution for 72 hr at room temperature. Blends series were prepared with different ratios of NR/SBR; 25/75, 30/70, 35/65, 40/60, 45/55, 50/50, and 55/45. Three types of carbon black (N-330, N-660, and N-762) were added individually to the 45/55 blend. Hardness, tensile strength, modulus, and elongation properties were tested before and after immersion in the 10% HCl attack media. All these mechanical properties decreased after immersion action accept hardness property. Up to 45 phr NR content, the hardness increased linearly independent on immersion action, but HCl immersion gives higher hardness values. Tensile strength increased up to 40 phr NR content with and without immersion and the immersion action decreased tensile values. The highest elongation value obtained with 35/65 blend with and without immersion. The 45 phr NR content gives the higher modulus, while the lowest value obtained with the 30 phhr content. For 45/55 blend, the hardness increased as the carbon black particle size decreased and immersion action gives higher hardness values. The tensile strength decreased linearly with the carbon black surface area, while with the medium surface area, the highest modulus and lowest elongation obtained.
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Rastogi, Radhika, Abhishek Deshpande, Phuc Le, Pei-Chun Yu, Peter Imrey, Ardeshir Hashmi i Michael Rothberg. "2206. Patterns of Care and Outcomes in Elderly Patients Hospitalized with Community-acquired Pneumonia in the United States". Open Forum Infectious Diseases 6, Supplement_2 (październik 2019): S752. http://dx.doi.org/10.1093/ofid/ofz360.2513.
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Abstract Background Community-acquired pneumonia (CAP) is a common cause of morbidity and mortality in the elderly. Few studies compare the elderly (>65) and very elderly (≥85 years). We aimed to describe characteristics and patterns of care for very elderly patients hospitalized with CAP. Methods We conducted a retrospective cohort study using administrative data from 2010 to 2015 of about 660 US hospitals in the Premier database. Adults aged ≥65 years hospitalized with CAP, identified by either a principal ICD-9 code of pneumonia or a principal diagnosis of sepsis or respiratory failure coupled with a secondary code for pneumonia, were included. We compared demographics, insurance status, comorbidities, presentation characteristics and treatments among three age groups: 65–74, 75–84, and ≥ 85 years. Results The final sample included 488,382 patients aged ≥65 years, a third of whom were ≥85 years. Geriatricians cared for <1% of patients during hospitalization, regardless of patient age. Compared with those aged 65–74 years, the patients ≥85 were more likely to be female, of white race, have Medicare insurance, and a principal diagnosis of aspiration pneumonia (17.1% vs. 7%) (Table 1). The oldest group had higher rates of cardiac comorbidities, chronic kidney disease and dementia, but lower rates of diabetes, obesity, pulmonary disease, and smoking. On presentation, more of the very elderly had concomitant urinary tract infections. They were less likely to receive opiates and benzodiazepines, but more likely to receive foley catheters and antipsychotic medications. Antibiotics given in the first 2 days were similar across the groups. Fewer very elderly patients were admitted to the ICU or got ventilation compared with younger groups. More of the very elderly were discharged to hospice and fewer were discharged home. Compared with younger ages, the very elderly had similar lengths of stay but lower costs, and higher in-hospital mortality and 30-day readmission. Conclusion The very elderly represent a unique population with distinct clinical characteristics and outcomes from younger elderly patients. They have different co-morbidities and appear to receive less aggressive treatment with lower costs and higher mortality despite similar lengths of stay. Disclosures All authors: No reported disclosures.
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Chou, Chia-Pei, Chun-Yu Chen, Kun-Siang Huang, Shih-Chun Lin, Chih-Fang Huang i Malcolm Koo. "Factors associated with nonadherence to antihypertensive medication among middle-aged adults with hypertension: findings from the Taiwan National Health Interview Survey". Journal of International Medical Research 48, nr 8 (sierpień 2020): ??? http://dx.doi.org/10.1177/0300060520936176.
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Objective We aimed to investigate factors associated with nonadherence to antihypertensive medication among middle-aged Taiwanese adults with hypertension. Methods We used data from the 2009 Taiwan National Health Interview Survey (NHIS) to identify adults age 40 to 65 years with hypertension. We used logistic regression analyses to investigate factors associated with nonadherence to antihypertensive medication. Results A total 1,256 respondents with hypertension taking antihypertensive medication were included in this study. Multiple logistic regression analyses revealed that six factors were significantly and independently associated with nonadherence to medication: younger age (odds ratio, [OR] = 1.85), mean monthly personal income < TWD 20,000 (USD 660) (OR = 1.87), outpatient medical services use in the past month (OR = 0.57), hospitalization in the past year (OR = 1.70), diabetes or dyslipidemia (OR = 0.63), and alcohol use in the past month (OR = 2.38). Conclusions This secondary data analysis of the population-based NHIS identified six factors associated with nonadherence to antihypertensive medication. These factors should be considered when planning and implementing blood pressure control interventions among middle-aged adults with hypertension.
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Delachapelle, S., M. Renaud i P. M. Vignais. "Etude de la production d'hydrogène en bioréacteur par une bactérie photosynthétique Rhodobacter capsulatus 1. Photobioréacteur et conditions optimales de production d'hydrogène". Revue des sciences de l'eau 4, nr 1 (12.04.2005): 83–99. http://dx.doi.org/10.7202/705091ar.
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Un réacteur de 10 litres, automatisé pour la culture continue en anaérobiose de bactéries photosynthétiques, a été réalisé et mis au point. Ce réacteur parfaitement agité a été utilisé dans différentes conditions de fonctionnement en système fermé (batch), en système semi-ouvert (atouts de substrats concentrés en discontinu), en système ouvert (chémostat) avec et sans recyclage de la biomasse, afin d'étudier la consommation, par les bactéries, d'un substrat carboné, le lactate. La production d'hydrogène par la bactérie photosynthétique Rhodobacter capsulatus, souche B10, résultant de la dégradation du lactate, est optimale pour des cultures en continu diluées, limitées en source azotée. Ainsi, à un taux de dilution de 0,04 h-1, avec 5 mM glutamate dans le milieu nutritif, la densité bactérienne étant de 2,1 è 660 nm, on a observé une production continue moyenne de 65 ml • h-1• l-1 pendant une période de 200 heures. Pour des concentrations bactériennes élevées, la limitation d'énergie lumineuse entrain une perte d'activité nitrogénase et, de ce fait, une chute de la production d'hydrogène.
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Thean, Li Jun, Adam Jenney, Daniel Engelman, Lucia Romani, Handan Wand, Jyotishna Mudaliar, Jessica Paka i in. "Hospital admissions for skin and soft tissue infections in a population with endemic scabies: A prospective study in Fiji, 2018–2019". PLOS Neglected Tropical Diseases 14, nr 12 (9.12.2020): e0008887. http://dx.doi.org/10.1371/journal.pntd.0008887.
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Scabies is an important predisposing factor for impetigo but its role in more serious skin and soft tissue infections (SSTIs) is not well understood. Information is limited on incidence of SSTIs in the presence of endemic scabies. We conducted a prospective study of hospital admissions for SSTIs in the Northern Division of Fiji (population: 131,914). Prospective surveillance for admissions with impetigo, abscess, cellulitis, wound infection, pyomyositis, necrotizing fasciitis, infected scabies, and crusted scabies was conducted at the Division’s referral hospital between 2018 to 2019. Information was collected on demographic characteristics, clinical features, microbiology, treatment and outcomes. Over the study period, 788 SSTI admissions were recorded corresponding to a population incidence 647 per 100,000 person-years (95%CI 571–660). Incidence was highest at the extremes of age with peak incidence in children aged <5 years (908 per 100,000) and those aged ≥65 years (1127 per 100,000). Incidence was 1.7 times higher among the Indigenous Fijian population (753 per 100,000) compared to other ethnicities (442 per 100,000). Overall case fatality rate was 3.3%, and 10.8% for those aged ≥65 years. Scabies was diagnosed concurrently in 7.6% of all patients and in 24.6% of admitted children <5 years. There is a very high burden of hospital admissions for SSTIs in Fiji compared to high-income settings especially among the youngest, oldest and indigenous population which is concordant with scabies and impetigo distribution in this population. Our findings highlight the need for strategies to reduce the burden of SSTIs in Fiji and similar settings.
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Ismaili, Mimoza. "Association between Central Corneal Thickness and Axial Length in Patients with Refractive Anomalies and Emmetropes". International Journal of Biomedicine 13, nr 3 (5.09.2023): 96–100. http://dx.doi.org/10.21103/article13(3)_oa7.
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Background: This study aimed to determine the correlation between central corneal thickness (CCT) and axial length (AL) in patients with refractive anomalies and emmetropes. Methods and Results: The study included 330 respondents, with a total of 660 eyes, divided into two groups. The test group (TG) included 180 respondents with refractive anomalies (65 respondents with hypertropia, 65 with myopia, and 50 with astigmatism); the control group (CG) included 150 respondents with uncorrected visual acuity – 6/6 in both eyes. The CCT values were higher in the hypermetropic group compared to the myopic group (561.5±25.3 vs. 517.9±37.3 mm, P<0.001), astigmatism group (561.5±25.3 vs. 528.3±35.3 mm, P<0.001) and the CG (561.5±25.3 vs. 553.3±18.5 mm, P<0.001). From 360 eyes in the TG with refractive anomalies, the lowest AL values were found in the hypermetropic group (21.7±1.0 mm) compared to the myopic group (P<0.001), the astigmatism group (P<0.001), and the CG (P<0.001). Similar differences were also found for the right eyes (OD): hypermetrops tend to have shorter AL than the astigmatic group (P<0.001), myopic group (P<0.001), and the CG (emmetrope) (P<0.001). Conclusion: The mean CCT value in the hyperopic group was higher than in the emmetropic group, while the CCT value of the myopic and astigmatic group was lower than that of the emmetropic group. AL values were the lowest in the hypermetropic group than in the myopic, astigmatic, and control groups.
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Punta, Gabriel. "MOVIMIENTOS POSTREPRODUCTIVOS DE CORMORANES IMPERIALES (PHALACROCRAX ATRICEPS) ANILLADOS EN LA PATAGONIA ARGENTINA". Ornitología Neotropical 26, nr 2 (6.02.2016): 143–55. http://dx.doi.org/10.58843/ornneo.v26i2.22.
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Postbreeding movements of ringed Imperial Cormorants (Phalacrocorax atriceps) in Patagonia, Argentina. – Very little is known about the movements of Imperial Cormorants (Phalacrocorax atriceps) during the postbreeding season in Patagonia. Here I use ringing to study the movements of Imperial Cormorants breeding on islands in the north of San Jorge Gulf, Chubut, Argentina. Between 1989 and 1993, 1706 Imperial Cormorants were ringed on Isabel, Galiano and Puente Islands. A total of 34 rings were recovered from dead cormorants while 4 ringed individuals were resighted. Recovery rates did not differ significantly between adults (2.2%) and juveniles (1.9%). Most (65%) recoveries and resightings were made north of the ringing sites near Península Valdés. On average cormorants were recovered or resighted 304 km away from the ringing site, with a maximum distance of 660 km. An individual ringed as an adult (> 2 years old) in the year 1990 was recovered dead at the end of the year 1999 indicating that it lived at least 12 years. Monthly recovery/resighting distances followed a bimodal distribution. This observation agrees with a pattern of northward movements after breeding (late summer) and southwards at the end of winter.
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Janssen, Ellen M., Craig E. Pollack, Cynthia Boyd, John F. P. Bridges, Qian-Li Xue, Antonio C. Wolff i Nancy L. Schoenborn. "How Do Older Adults Consider Age, Life Expectancy, Quality of Life, and Physician Recommendations When Making Cancer Screening Decisions? Results from a National Survey Using a Discrete Choice Experiment". Medical Decision Making 39, nr 6 (21.06.2019): 621–31. http://dx.doi.org/10.1177/0272989x19853516.
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Background. Older adults with limited life expectancy frequently receive cancer screening, although on average, harms outweigh benefits. We examined the influence of life expectancy on older adults’ cancer screening decisions relative to three other factors. Methods. Adults aged 65+ years ( N = 1272) were recruited from a national online survey panel. Using a discrete choice experiment, we systematically varied a hypothetical patient’s life expectancy, age, quality of life, and physician’s recommendation and asked whether the participant would choose screening. Participants were randomized to questions about colonoscopy or prostate-specific antigen/mammography screenings. Logistic regression produced preference weights that quantified the relative influence of the 4 factors on screening decisions. Results. 879 older adults completed the survey, 660 of whom varied their screening choices in response to the 4 factors we tested. The age of the hypothetical patient had the largest influence on choosing screening: the effect of age being 65 versus 85 years had a preference weight of 2.44 (95% confidence interval [CI]: 2.22, 2.65). Life expectancy (10 versus 1 year) had the second largest influence (preference weight: 1.64, CI: 1.41, 1.87). Physician recommendation (screen versus do not screen) and quality of life (good versus poor) were less influential, with preference weights of 0.90 (CI: 0.72, 1.08) and 0.68 (CI: 0.52, 0.83), respectively. Conclusions. While clinical practice guidelines increasingly use life expectancy in addition to age to guide screening decisions, we find that age is the most influential factor, independent of life expectancy, quality of life, and physician recommendation, in older adults’ cancer screening choices. Strategies to reduce overscreening should consider the importance patients give to continuing screening at younger ages, even when life expectancy is limited.
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Taherzadeh-Sani, Mohammad, i Anas Hamoui. "Correction to “A 1-V Process-Insensitive Current-Scalable Two-Stage Opamp With Enhanced DC Gain and Settling Behavior in 65-nm Digital CMOS” [Mar 11 660-668]". IEEE Journal of Solid-State Circuits 47, nr 6 (czerwiec 2012): 1497. http://dx.doi.org/10.1109/jssc.2012.2193516.
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DuMontier, Clark, Kerri Clough-Gorr, Rebecca A. Silliman, Andreas Stuck i André Moser. "Using health-related quality of life and treatment measures to predict 10-year mortality in older survivors of early stage breast cancer." Journal of Clinical Oncology 35, nr 15_suppl (20.05.2017): e21548-e21548. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e21548.
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e21548 Background: Older women make up the growing majority of breast cancer (BC) survivors. Guideline BC treatments are known contributors to long-term survival, and health-related quality of life (HRQOL) is emerging as not only an important outcome in survivorship care but also as a factor thought to influence mortality. However, prognostic models that include HRQOL alongside BC treatment measures are lacking. We aimed to develop a 10-year mortality risk score based on a priori chosen treatment and HRQOL variables. Methods: We studied 660 women ≥65-years old diagnosed with stage I-IIIA primary breast cancer in years 1997-1999. Data from medical and psychosocial domains were collected over 10 years from interviews, medical records, and death indexes. BC treatment variables included receipt of definitive locoregional surgery +/- radiation, chemotherapy, and tamoxifen. HRQOL variables included physical function [10-item Physical Function Index (PFI-10) from the Medical Outcomes Study Short Form-36 (MOS SF-36)]; mental health [5-item Mental Health Index (MHI-5) from the MOS SF-36]; and social support [8-item modified MOS Social Support Scale (mMOS-SSS)]. We used penalized logistic regression models to develop a 10-year mortality risk score, and investigated its discrimination (c-statistic) and calibration (observed versus predicted mortality using the Hosmer-Lemeshow (HL) test). Results: Mortality though 10-years of follow-up was 34.8% (230 of 660 women). The c-statistic of a risk score using only age, number of comorbidities, stage of BC, and BC treatment was 0.71. The c-statistic increased to 0.74 with the addition of HRQOL measures and showed good calibration (p = 0.72 from HL test). Physical function and mental health had strong independent associations with mortality (women with high PFI-10: OR 0.63, 95% CI 0.43, 0.92; women with high MHI-5: OR 0.57, 95% CI 0.39, 0.85). Conclusions: In older early stage breast cancer survivors, our risk score combining HRQOL with treatment measures showed good discrimination and calibration. HRQOL is independently associated with 10-year mortality and adds predictive ability to age, comorbidity, stage of BC, and BC treatment.
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Dalhatu, A. S., R. Hussin, B. Ibrahim, Y. A. Yamusa i A. Baballe. "LUMINESCENCE BEHAVIOUR OF DY3+ ION DOPED MAGNESIUM SULFOBORATE PHOSPHOR FOR WHITE LIGHT EMITTING DIODES". Open Journal of Physical Science (ISSN: 2734-2123) 1, nr 1 (10.03.2020): 11–15. http://dx.doi.org/10.52417/ojps.v1i1.85.
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Several studies showed the interesting properties of trivalent lanthanide ions when doped in various types of phosphor. Magnesium sulfoborate phosphor doped with different concentrations of Dy3+ were synthesized using solid-state reaction method at 850 °C for 4 hours. The samples were characterized by X-ray Diffraction (XRD). The excitation and luminescence properties of MgO-SO4-B2O3:Dy3+ were determined. The emission spectrum of Dy3+ ion doped MgO-SO4-B2O3 phosphor exhibit three bands at 480 nm, 573 nm and 660 nm with excitation of 386 nm due to 4F9/2 →6H15/2, 6H13/2 and 6H11/2 of Dy3+ transitions, respectively. The excitation spectrum of Dy3+ ion doped MgO-SO4-B2O3 phosphor display several bands at 347 nm, 362 nm, 386 nm, 426 nm, 449 nm and 469 nm with emission of 573 nm, which is in agreement with the ultraviolet LED (349.9–410 nm) and blue LED (450–470 nm). An intense in the emission peak at 573 nm in the yellow region was observed with the 0.5 Dy2O3. The luminescence properties of phosphor show that MgO-SO4-B2O3:Dy3+ phosphor could be potentially used as white LEDs.
Dalhatu, A. S. | Department of Physics, Bauchi State University Nigeria, 65 Gadau, Bauchi, Nigeria
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Hamid, Mohd Azhar Abd, Hamidi Abdul Aziz, Mohd Suffian Yusoff i Sheikh Abdul Rezan. "Optimization and Analysis of Zeolite Augmented Electrocoagulation Process in the Reduction of High-Strength Ammonia in Saline Landfill Leachate". Water 12, nr 1 (16.01.2020): 247. http://dx.doi.org/10.3390/w12010247.
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This work examined the behavior of a novel zeolite augmented on the electrocoagulation process (ZAEP) using an aluminum electrode in the removal of high-strength concentration ammonia (3471 mg/L) from landfill leachate which was saline (15.36 ppt) in nature. For this, a response surfaces methodology (RSM) through central composite designs (CCD) was used to optimize the capability of the treatment process. Design-Expert software (version 11.0.3) was used to evaluate the influences of significant variables such as zeolite dosage (100–120 g), current density (540–660 A/m2), electrolysis duration (55–65 min), and initial pH (8–10) as well as the percentage removal of ammonia. It is noted that the maximum reduction of ammonia was up to 71%, which estimated the optimum working conditions for the treatment process as follows: zeolite dosage of 105 g/L, the current density of 600 A/m2, electrolysis duration of 60 min, and pH 8.20. Furthermore, the regression model indicated a strong relationship between the predicted values and the actual experimental results with a high R2 of 0.9871. These results provide evidence of the ability of the ZAEP treatment as a viable alternative in removing high-strength landfill leachate of adequate salinity without the use of any supporting electrolyte.
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Iyer, Vivek N., Waleed Brinjikji, Dinesh Apala, Bibek S. Pannu, Aditya Kotecha, Michael D. Leise, Patrick S. Kamath i in. "Impact of Age on Outcomes in Hospitalized Patients with Hereditary Hemorrhagic Telangiectasia". Advances in Hematology 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/4798425.
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Background. There is little published literature regarding the impact of age on outcomes amongst hospitalized HHT (hereditary hemorrhagic telangiectasia) patients. Methods. The Nationwide Inpatient Sample (NIS) was used to obtain data on all hospital discharges occurring in HHT patients from 2000 to 2012. The association between admission age and HHT-related complications and outcomes were studied. Results. 10293 hospitalizations in HHT patients from 2000 to 2012 were included. Patients > 50 accounted for 77% of all admissions with 30% of admissions occurring in the 51–65 age group. Bleeding related complications were the most frequent (62.7%, n=6455 hospitalizations), followed by cardiovascular (41%, n=4216), neurological (12.4%, n=1276), and hepatobiliary (6.4%, n=660) complications. Patients older than 50 accounted for 83% of bleeding events, 90% of cardiovascular events, 58% of neurologic events, and 81% of hepatobiliary events. The vast majority (83%) of medical and surgical procedures were performed in those older than 50 years of age. Older patients also experienced higher rates of death. Conclusion. Aging has significant adverse impacts on rates of hospitalization, complications, and outcomes amongst HHT patients in the United States. Except for neurologic complications, the vast majority of this disease burden is borne by patients older than 50 years.
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Küçükcankurtaran, Sevtap, i Yahya Özdoğan. "Attitudes and behavior of adults about food safety during the COVID-19 pandemic". Demiroglu Science University Florence Nightingale Journal of Medicine 7, nr 2 (1.08.2021): 126–32. http://dx.doi.org/10.5606/fng.btd.2021.25059.
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Objectives: Ensuring food security is of global importance to prevent human exposure during the coronavirus disease (COVID-19) pandemic. This study aimed to evaluate the adult attitudes and behaviors regarding food safety during the period of the COVID-19 pandemic. Materials and methods: The sample of the study consisted of 660 individuals (131 males, 529 females; median age: 25 [IQR 13.0]; range, 20 to 65 years) living in Turkey. The disinfection procedures that individuals apply to raw vegetables and fruits, their behavior during shopping, and their access to information regarding food safety during the COVID-19 pandemic were questioned. The data were analyzed using the Mann-Whitney U test and the chi-square test. Results: In the disinfection of foods, adults preferred vinegar (95.6%) the most. The relationship between sex and disinfection of raw vegetables and fruits was found to be statistically significant (p<0.05). It was determined that 98.8% of the participants paid attention to social distancing during shopping, 99.2% wore masks, and information regarding food safety was accessed more via social media (57.3%). Conclusion: It was determined that changes occurred in individuals' attitudes and behaviors regarding food safety during the pandemic. Further studies are needed to determine the impact of changes in COVID-19 and food safety on humans.
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Kharin, Yu S. "Neural network-based models of binomial time series in data analysis problems". Doklady of the National Academy of Sciences of Belarus 65, nr 6 (26.12.2021): 654–60. http://dx.doi.org/10.29235/1561-8323-2021-65-6-654-660.
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This article is devoted to constructing neural network-based models for discrete-valued time series and their use in computer data analysis. A new family of binomial time series based on neural networks is presented, which makes it possible to approximate the arbitrary-type stochastic dependence in time series. Ergodicity conditions and an equivalence relation for these models are determined. Consistent statistical estimators for model parameters and algorithms for computer data analysis (including forecasting and pattern recognition) are developed.
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Morozov, Boris N. "Alexander the Great, King of Macedonia, and Prince Mikhail Skopin-Shuisky. Two Manuscripts of “Alexandria” with Continuation in the Time of Troubles". Bibliotekovedenie [Library and Information Science] 65, nr 6 (1.01.2016): 649–60. http://dx.doi.org/10.25281/0869-608x-2016-65-6-649-660.
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Ismaili, Mimoza. "Association Between Central Corneal Thickness and Intraocular Pressure in Patients with Refractive Anomalies and Emmetropes". International Journal of Biomedicine 13, nr 3 (5.09.2023): 91–95. http://dx.doi.org/10.21103/article13(3)_oa6.
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Background: The aim of this study was to determine the relationship between central corneal thickness (CCT) and intraocular pressure (IOP) in patients with refractive anomalies and emmetropes. Methods and Results: This retrospective study was conducted in the Department of Ophthalmology at the University Clinical Center. The study included 330 respondents, with a total of 660 eyes, divided into two groups. The test group (TG) included 180 respondents with refractive anomalies (65 respondents with hypertropia, 65 with myopia, and 50 with astigmatism); the control group (CG) included 150 respondents with uncorrected visual acuity – 6/6 in both eyes. All respondents included in the research were aged 18–40, with an average age of 22.9 years. The values of CCT in TG was around 499.3–577.1 μm. From 360 eyes in the TG with refractive anomalies, the highest IOP values were found in the astigmatic group (20.6 mmHg) and the lowest values in the myopic group (15.3 mmHg) (P<0.001) and were statistically higher compared to the CG (P<0.001 in both cases). We found a statistically significant, moderate positive correlation between the values of CCT and IOP in the hypermetropic group (rs=0.655, 95% CI: 0.540 to 0.745, P<0.0001) and a statistically significant low negative correlation (rs=-0.209, 95% CI: -0.373 to -0.033, P=0.0165) between the values of CCT and IOP in the myopic group. Also, a statistically significant low negative correlation (rs=-0.304, 95% CI: -0.510 to -0.152, P=0.0005) was found between the values of CCT and IOP in the astigmatism group. Conclusion: The results of our study show that increasing the CCT values in the hypermetropic group leads to an increase in the IOP values. Therefore, these findings can be used as a reference for our population, which would assist in the early diagnosis of ocular hypertension.
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Karlssonl, Meriam, i Jarle Nilsen. "Light Quality Initiating or Ending the Day Affects Internode Length in Petunia". HortScience 30, nr 4 (lipiec 1995): 861C—861. http://dx.doi.org/10.21273/hortsci.30.4.861c.
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`Ultra Rose Star' petunia plants were germinated and grown at 21C. The study was initiated 26 days after seeding and the photoperiod was 15 h of light and 9 h of darkness. During the initial or ending 90 min of the light period, the plants were exposed to a light quality of a higher (≈2.0) or lower (≈0.8) red (R, 660 nm) to far red (FR, 730 nm) ratio than daylight (R: FR, ≈1.1). Flowering occurred within 65 days from seeding for plants in all treatments. Plants receiving a low R: FR during the initial 90 min of the day had similar internode lengths as those plants receiving a high R: FR at the end of the day. The average internode length of the main stem at flowering was 0.6 ± 0.08 cm for plants receiving a low R: FR in the morning or a high R: FR at the end of the day. In addition, the internodes of those plants exposed to a low R: FR in the morning were longer than on plants receiving a low R: FR at night or a high R: FR in the morning. The average internode length at flowering was 0.4 ± 0.08 cm for plants with an ending low R: FR or a beginning high R: FR light quality of the day.
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Santos, Leslie Dos, Devon Powers, Ryszard Wycisk i Peter N. Pintauro. "Electrospun Hybrid Perfluorosulfonic Acid/Sulfonated Silica Composite Membranes". Membranes 10, nr 10 (23.09.2020): 250. http://dx.doi.org/10.3390/membranes10100250.
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Electrospinning was employed to fabricate composite membranes containing perfluorosulfonic acid (PFSA) ionomer, poly(vinylidene fluoride) (PVDF) reinforcement and a sulfonated silica network, where the latter was incorporated either in the PFSA matrix or in the PVDF fibers. The best membrane, in terms of proton conductivity, was made by incorporating the sulfonated silica network in PFSA fibers (Type-A) while the lowest conductivity membrane was obtained when sulfonated silica was incorporated into the reinforcing PVDF fibers (Type-B). A Type-A membrane containing 65 wt.% PFSA with an embedded sulfonated silica network (at 15 wt.%) and with 20 wt.% PVDF reinforcing fibers proved superior to the pristine PFSA membrane in terms of both the proton conductivity in the 30–90% RH at 80 °C (a 25–35% increase) and lateral swelling (a 68% reduction). In addition, it was demonstrated that a Type-A membrane was superior to that of a neat 660 EW perfluoroimide acid (PFIA, from 3M Co.) films with respect to swelling and mechanical strength, while having a similar proton conductivity vs. relative humidity profile. This study demonstrates that an electrospun nanofiber composite membrane with a sulfonated silica network added to moderately low EW PFSA fibers is a viable alternative to an ultra-low EW fluorinated ionomer PEM, in terms of properties relevant to fuel cell applications.
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Casey, R. G., P. K. Hegarty, R. Conroy, D. Rea, M. R. Butler, R. Grainger, Ted McDermott i J. A. Thornhill. "The Distribution of PSA Age-Specific Profiles in Healthy Irish Men between 20 and 70". ISRN Oncology 2012 (26.07.2012): 1–4. http://dx.doi.org/10.5402/2012/832109.
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Background. Ireland is estimated to have the highest European incidence rate of prostate cancer (Pca) in 2006 which will increase by 275% by 2025. This study aimed to determine PSA cutoff values in different age groups of healthy male patients without Pca. Methods. 660 men in a pilot men’s health programme, aged 18–67, had PSA assayed. Men were grouped into 8 age groups at 5-year intervals: 30–34, 35–39, 40–44, 45–49, 50–54, 55–59, 60–64, and 64–70. Results. Linear regression demonstrates a PSA velocity of 0.024 ng/ml/year. The 95% confidence interval demonstrates a near flat line of PSA values from age 20 to 50 and rises after. When transformed logarithmically, PSA correlates highly with expected values from the normal distribution (0.98). A fractional polynomial quantile regression model was used to predict median and 95th percentile for PSA as follows: 30–34 (0.73, 1.57), 35–39 (0.71, 1.65), 40–44 (0.73, 1.85), 45–49 (0.78, 2.17), 50–54 (0.88, 2.63), 55–59 (1.01, 3.25), 60–64 (1.20, 4.02), and 64–70 (1.43, 4.96). Conclusions. PSA levels are similar to other racial groups but not as high as US Caucasians until 65 years. These data define the predicted PSA for the Irish population and provide a reference for future screening programmes.
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Restle, João, Luís Fernando Glasenapp de Menezes, Miguelangelo Ziegler Arboitte, Leonir Luiz Pascoal, Paulo Santana Pacheco i João Teodoro Pádua. "Características das partes não-integrantes da carcaça de novilhos 5/8Nelore 3/8Charolês abatidos em três estádios de desenvolvimento". Revista Brasileira de Zootecnia 34, nr 4 (sierpień 2005): 1339–48. http://dx.doi.org/10.1590/s1516-35982005000400031.
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Foram avaliadas as características das partes não-integrantes da carcaça de novilhos 5/8 Nelore 3/8 Charolês terminados em confinamento e abatidos com 425, 467 e 510 kg. Os períodos de alimentação foram 30, 65 e 94 dias, respectivamente. A idade e peso médio iniciais foram de 660 dias e 361 kg, respectivamente. A dieta alimentar, com relação volumoso:concentrado de 60:40 com base na matéria seca (MS), continha 10,25% de proteína bruta e 3,18 Mcal de energia digestível/kg MS. De acordo com estimativa da equação de regressão, os rendimentos de carcaças quente e fria elevaram com o aumento no peso de abate (P). No entanto, quando expressos por peso de corpo vazio (PCV), houve similaridade entre os diferentes tratamentos. Quando os componentes foram expressos em valores absolutos, couro, total de componentes externos (TCE), fígado, total de órgãos vitais (TOV), total de gorduras internas (TGORD) e total de trato gastrintestinal vazio (TGVZ) apresentaram incremento com o aumento no P. Quando expressos por 100 kg de P e PCV, os componentes couro, TCE, fígado e TGVZ apresentaram similaridade; coração e TOV, decréscimo; e TGORD, acréscimo, com o aumento no P. Houve correlação positiva entre peso de fígado com consumo de matéria seca (r = 0,91) e com energia líquida de mantença (ELm) (r = 0,91) e entre TGORD com ELm (r = 0,78).
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Özdoğan, Yahya, i Rahime Evra Karakaya. "Çevrim İçi Yemek Siparişlerine Yönelik Beslenme Alışkanlıklarının ve Satın Alma Niyetlerinin Değerlendirilmesi". İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi, nr 22 (30.04.2024): 238–52. http://dx.doi.org/10.38079/igusabder.1221811.
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Amaç: Bu araştırmanın amacı, tüketicilerin çevrim içi yemek siparişlerine yönelik satın alma niyetleri ile beslenme alışkanlıkları arasındaki ilişkinin değerlendirilmesidir. Yöntem: Çalışma, 18-65 yaş aralığındaki 660 birey ile yürütülmüştür. Çevrim içi yemek siparişlerine yönelik beslenme alışkanlıklarına yönelik sorular daha önce yapılan çalışmalardan yararlanılarak hazırlanmıştır. Tüketicilerin çevrim içi yemek siparişlerini etkileyen faktörleri değerlendirmek amacıyla daha önce yapılan anketlerin soruları uyarlanmıştır. İstatistiksel analizler SPSS 22.0 paket programı ile yapılmıştır. Bulgular: Katılımcıların yarıdan fazlasının (%61,6) akşam çevrim içi yemek siparişi verdiği ve yüksek oranda karbonhidrat ağırlıklı (%84,5) yemekleri tercih ettikleri saptanmıştır. Çevrim içi yemek siparişlerine yönelik satın alma niyeti incelendiğinde; anketin tüm alt boyut puanlarının kadınlarda erkeklerden istatistiksel olarak daha yüksek olduğu tespit edilmiştir (p<0.05). Kadınlarda ve tüm katılımcılarda, haftada 1-2 kez çevrim içi yemek siparişi veren bireylerin çevrim içi yemek siparişinin algılanan rahatlığı puanı, ayda 1-2 kez sipariş veren bireylerin puanından anlamlı olarak yüksektir (p<0,05). Kadınlarda ve tüm katılımcılarda yeme arzusu alt boyutu ile beden kütle indeksi arasında çok zayıf derecede negatif ilişki saptanmıştır (sırasıyla, r=-0,090, p=0,046; r=-0,116; p=0,003). Sonuç: Çevrim içi yemek siparişi verme sıklığının algılanan rahatlık boyutu ile daha fazla olduğu için sipariş verme sıklığının arttığı düşünülmektedir. Bireylerin sipariş vermelerinde bir etken olan yemek arzularının, beden kütle indeksleri ile ilişkilendirildiği daha fazla çalışmaya ihtiyaç vardır.
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Lau, Chin Shern, May Lin Helen Oh, Soon Kieng Phua, Ya-Li Liang i Tar Choon Aw. "210-Day Kinetics of Total, IgG, and Neutralizing Spike Antibodies across a Course of 3 Doses of BNT162b2 mRNA Vaccine". Vaccines 10, nr 10 (12.10.2022): 1703. http://dx.doi.org/10.3390/vaccines10101703.
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Introduction: We tested the total spike antibody (S-Ab), IgG/IgM S-Ab, and neutralizing antibody (N-Ab) responses of COVID-19-naïve subjects from before their first BNT162b2 vaccination up to 210 days after boosting. Methods: We studied 136 COVID-19-naïve subjects who received three doses of the Pfizer mRNA vaccine (39 males, 97 females, mean age 43.8 ± 13.5 years) from January 2021 to May 2022. Serum was assessed for total S-Ab (Roche), IgG/M (Abbott), and N-Ab (Snibe). Results: Peak antibody levels were measured 20-30 days after each dose, with booster dosing eliciting significantly higher peak antibodies than the second dose: total S-Ab 2219 vs. 19,551 BAU/mL (difference 16,667 BAU/mL, p < 0.0001); IgG 2270 vs. 2932 BAU/mL (difference 660 BAU/mL, p = 0.04); and N-Ab 3.52 vs. 26.4 µg/mL (difference 21.4 µg/mL, p < 0.0001). Only IgM showed a lower peak post-booster antibody titer (COI 2.11 vs. 0.23, difference 1.63, 95% CI 1.05 to 2.38, p < 0.0001). By 180–210 days after the second or third vaccination, total S-Ab/IgG/N-Ab had decreased by 68.7/93.8/73.6% vs. 82.8/86.3/79.5%. The half-lives of IgG and N-Ab antibodies were longer after the third vaccination (IgG: 65 vs. 34 days, N-Ab: 99 vs. 78 days). Conclusion: Total S-Ab/IgG/N-Ab showed a greater increase post-booster, with IgG/N-Ab having a longer half-life.
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Dionne, Jean-Claude, i Stephen Poitras. "Observations géomorphologiques sur la batture à méga-blocs, à Petite-Rivière, Charlevoix, Québec". Géographie physique et Quaternaire 50, nr 2 (30.11.2007): 221–32. http://dx.doi.org/10.7202/033090ar.
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RÉSUMÉ À Petite-Rivière (Charlevoix), Ie rivage se caractérise par une batture atteignant 1100 m de largeur sur plus de 15 km de longueur. Cette vaste surface plane à pente faible (0,45 %) a été taillée dans divers dépôts quaternaires anciens dont des rythmites limono-argileuses datées à circa 65 ka. Elle est couverte de minces placages de vase, sable, gravier et petits cailloux et de gros blocs dont un grand nombre de taille démesurée. Des 533 blocs mesurés, 48,4 % ont un grand axe (axe a) compris entre 3 et 4 m, 22,5 % de 4 à 5 m et 8,4 % de plus de 5 m. Le plus gros bloc (840 x 660 x 450 cm) pèse environ 467 tonnes métriques. Tous les blocs proviennent du Bouclier précambrien à proximité. À l'exception des plus gros, plusieurs méga-blocs ont subi récemment des déplacements généralement inférieurs à 5 m. La taille d'un grand nombre de blocs excède la compétence habituelle des glaces dans un milieu macro-tidal avec une amplitude des marées de vive eau d'environ 6 m. Bien que des apports anciens par les icebergs soient envisageables, la plupart des méga-blocs semblent provenir de l'érosion de dépôts glaciaires en bordure ou sur le rivage actuel. La majorité des méga-blocs n'auraient donc pas été mis en place directement par les glaces flottantes. La grande batture de Petite-Rivière est une plate-forme d'érosion avec des débris grossiers résiduels.
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Lecerf, F., B. L. Nguyen i J. R. Pasqualini. "Biological effects and ultrastructural alterations of cis-tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen in the uterus and vagina of newborn guinea pigs". Acta Endocrinologica 119, nr 1 (wrzesień 1988): 85–90. http://dx.doi.org/10.1530/acta.0.1190085.
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Abstract. The biological and morphological effects of cis-tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen, administered sc alone (100 μg/animal) or combined with estradiol (20 μg/animal) were studied in the uterus and vagina of the guinea pig. After 2 days treatment the values of the uterine wet weights (mg ± sd of 6–10 animals in each study) were as follows: non-treated animals (control): 142 ± 15; animals treated with cis-tamoxifen: 119 ± 4; N-desmethyltamoxifen: 280 ± 20; 4-hydroxytamoxifen: 268 ± 25. The values after long treatment were: 177 ± 30; 490 ± 65; 394 ± 36 and 581 ± 60, respectively. After short treatment the weights of the vaginas were: control: 99 ± 20; cis-Tamoxifen: 67 ± 2; N-desmethyltamoxifen: 153 ± 25; 4-hydroxytamoxifen: 166 ± 7; and after the long treatment: 155 ± 40; 660 ± 41; 467 ± 38 and 502 ±61, respectively. N-desmethyltamoxifen and 4-hydroxytamoxifen increased the progesterone receptors in the uterus after short treatment (P < 0.01) but not after 12 days treatment. On the other hand, there was no effect on progesterone receptor in the vagina after the short treatment but a very stimulatory effect after the long treatment. The morphological alterations after 12-days treatment indicate that the three tamoxifen derivatives in the two tissues studied provoke intense alterations in different organelles. In conclusion, it is suggested that the tamoxifen derivatives can act as real agonists in the uterus and vagina of the newborn guinea pig, and they do not block the effect provoked by estradiol.
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Sebeay, Tamer Ali, i Azzam Ahmed. "Numerical Investigation into GFRP Composite Pipes under Hydrostatic Internal Pressure". Polymers 15, nr 5 (23.02.2023): 1110. http://dx.doi.org/10.3390/polym15051110.
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Glass-fiber-reinforced plastic (GFRP) composite pipes are used extensively in high-performance applications, due to their high stiffness and strength, corrosion resistance, and thermal and chemical stability. In piping, composites showed high performance due to their long service life. In this study, glass-fiber-reinforced plastic composite pipes with [±40]3, [±45]3, [±50]3, [±55]3, [±60]3, [±65]3, and [±70]3 fiber angles and varied pipe wall thicknesses (3.78–5.1 mm) and lengths (110–660 mm) were subjected to constant hydrostatic internal pressure to obtain the pressure resistance capacity of the glass-fiber-reinforced plastic composite pipe, hoop and axial stress, longitudinal and transverse stress, total deformation, and failure modes. For model validation, the simulation of internal pressure on a composite pipe installed on the seabed was investigated and compared with previously published data. Damage analysis based on progressive damage in the finite element model was built based on Hashin damage for the composite. Shell elements were used for internal hydrostatic pressure, due to their convenience for pressure type and property predictions. The finite element results observed that the winding angles from [±40]3 to [±55]3 and pipe thickness play a vital role in improving the pressure capacity of the composite pipe. The average total deformation of all designed composite pipes was 0.37 mm. The highest pressure capacity was observed at [±55°]3 due to the diameter-to-thickness ratio effect.
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Bergerot, Cristiane Decat, Jasnoor Malhotra, Paulo Gustavo Bergerot, Errol James Philip, Daniela V. Castro, Ameish Govindarajan, Lorena Nascimento Manrique Molina i in. "Improved health-related quality of life (HR-QOL) with use of an online mindfulness tool in patients with metastatic renal cell carcinoma (mRCC) receiving immunotherapy (IO)." Journal of Clinical Oncology 41, nr 6_suppl (20.02.2023): 660. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.660.
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660 Background: Previous randomized studies have shown the benefit of interventions to increase mindfulness in multiple cancer types, including prostate cancer (Chambers et al JCO 2017), but limited data exists in mRCC. We sought to determine the effect of an app-based mindfulness intervention on anxiety, fear of cancer progression (FCR), fatigue and HR-QOL in this population. Methods: Eligible patients had mRCC, were receiving IO, had measurable symptoms of anxiety or FCR, had a smartphone with internet access and had not participated in a mindfulness program in the past 5 years. Patients were recruited in Brazil across 7 private centers and one academic center in the US. We evaluated the Mindfulness-Based Cancer Survivorship Journey, a program within the Am Mindfulness smartphone app (AmDTx). Patients used AmDTx for 20-30 minutes each day for a minimum of 4 days per week over a period of 4 weeks. Patients were assessed at baseline (T1) and at weeks 2 (T2), 4 (T3) and 12 (T4) using the PROMIS-Anxiety, FCR-7, Brief Fatigue Inventory (BFI), and Functional Assessment of Chronic Illness Therapy-General (FACT-G). RM-ANOVA was used to test the effect of time on symptoms and on HR-QOL. Results: A total of 41 patients were recruited; median age was 59 (range, 36-79) and patients were predominantly male (70%), white (61%), married (75%) and well educated (65% had at least a college degree). Most patients were receiving nivolumab/ipilimumab (44%), nivolumab (22%) or axitinib/pembrolizumab (9%). Symptoms of anxiety significantly decreased from 21.6 + 4.8 to 12.5 + 5.1 (P=0.001). Similar findings were found for FCR (MT1=21.4 to MT4=13.5, P=0.001) and fatigue (MT1=32.0 to MT4=19.4, P=0.001). Notably, HR-QOL increased from 81.1 + 13.4 to 92.7 + 14.9 (P=0.001). No significant differences were identified based on disease characteristics or type of therapy. Conclusions: The current study suggests that smartphone-based mindfulness intervention could improve HR-QOL and decreased FCR, anxiety and fatigue. This low-cost, easily accessible intervention may provide an important alternative to in-person psychosocial support for patients with mRCC and should be assessed in randomized trials in this disease. Funding: Kure It Cancer Research: 2020 Barry Hoeven Memorial Kidney Cancer Research Grant (PI: C D Bergerot).
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Sullivan, Amy P., Rudra P. Pokhrel, Yingjie Shen, Shane M. Murphy, Darin W. Toohey, Teresa Campos, Jakob Lindaas, Emily V. Fischer i Jeffrey L. Collett Jr. "Examination of brown carbon absorption from wildfires in the western US during the WE-CAN study". Atmospheric Chemistry and Physics 22, nr 20 (18.10.2022): 13389–406. http://dx.doi.org/10.5194/acp-22-13389-2022.
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Abstract. Light absorbing organic carbon, or brown carbon (BrC), can be a significant contributor to the visible light absorption budget. However, the sources of BrC and the contributions of BrC to light absorption are not well understood. Biomass burning is thought to be a major source of BrC. Therefore, as part of the WE-CAN (Western Wildfire Experiment for Cloud Chemistry, Aerosol Absorption and Nitrogen) study, BrC absorption data were collected on board the National Science Foundation/National Center for Atmospheric Research (NSF/NCAR) C-130 aircraft as it intercepted smoke from wildfires in the western US in July–August 2018. BrC absorption measurements were obtained in near real-time using two techniques. The first coupled a particle-into-liquid sampler (PILS) with a liquid waveguide capillary cell and a total organic carbon analyzer for measurements of water-soluble BrC absorption and WSOC (water-soluble organic carbon). The second employed a custom-built photoacoustic aerosol absorption spectrometer (PAS) to measure total absorption at 405 and 660 nm. The PAS BrC absorption at 405 nm (PAS total Abs 405 BrC) was calculated by assuming the absorption determined by the PAS at 660 nm was equivalent to the black carbon (BC) absorption and the BC aerosol absorption Ångström exponent was 1. Data from the PILS and PAS were combined to investigate the water-soluble vs. total BrC absorption at 405 nm in the various wildfire plumes sampled during WE-CAN. WSOC, PILS water-soluble Abs 405, and PAS total Abs 405 tracked each other in and out of the smoke plumes. BrC absorption was correlated with WSOC (R2 value for PAS =0.42 and PILS =0.60) and CO (carbon monoxide) (R2 value for PAS =0.76 and PILS =0.55) for all wildfires sampled. The PILS water-soluble Abs 405 was corrected for the non-water-soluble fraction of the aerosol using the calculated UHSAS (ultra-high-sensitivity aerosol spectrometer) aerosol mass. The corrected PILS water-soluble Abs 405 showed good closure with the PAS total Abs 405 BrC with a factor of ∼1.5 to 2 difference. This difference was explained by particle vs. bulk solution absorption measured by the PAS vs. PILS, respectively, and confirmed by Mie theory calculations. During WE-CAN, ∼ 45 % (ranging from 31 % to 65 %) of the BrC absorption was observed to be due to water-soluble species. The ratio of BrC absorption to WSOC or ΔCO showed no clear dependence on fire dynamics or the time since emission over 9 h.
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Palmer, Michael H., i Alistair D. Nelson. "Corrigendum to “The structures of the azido-, isocyanato- and isothiocyanato-derivatives of methane and silane and their derivatives. A comparison of ab initio with experimental results” [J. Molstruc. 660 (2003) 49–65]". Journal of Molecular Structure 689, nr 1-2 (luty 2004): 159. http://dx.doi.org/10.1016/j.molstruc.2003.12.016.
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Shrikhande, Shailesh V., Bhawna Sirohi, Alok Gupta, Vipul Sheth, Mukta Ramadvar, Mahesh Goel i Ashwin Desouza. "Is greater downstaging achieved if surgery is delayed beyond 8 weeks in patients with locally advanced (LA) rectal cancer?" Journal of Clinical Oncology 32, nr 3_suppl (20.01.2014): 660. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.660.
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660 Background: Neoadjuvant Chemoradiotherapy (NACTRT) improves local recurrence rate in LA rectal cancer with no survival benefit. Pathological complete response (pCR) and better tumour regression grade (TRG) is associated with improved outcome. Debate is ongoing as to what is the best time to operate—if greater downstaging can be achieved by a longer interval to surgery and have an impact on sphincter saving surgery rates. In this study, we have correlated the pCR rate and TRG post completion of NACTRT with timing of surgery (TD). Methods: This is a retrospective study of prospective database of patients with LA adenocarcinoma of rectum treated from Jan 2012 to May 2013. 89 pts who completed NACTRT (50Gy/25 fractions with capecitabine 825 mg/m2BD) followed by surgical resection were included. For response evaluation patients were divided into two groups, group 1 (TD < 60 days, n=34) and 2 (TD > 60 days, n=55). Results: Of 89 pts (median age 48 y (22-76), 64 M/25F; 16/89 (18%) had signet ring histology) 93% pts underwent R0 resection; 7% R1 resection. Response to NACTRT was CR in 8 pts, PR in 65 (73%) pts and 15 SD, 1 not assessed. Median time from completion of NACTRT to surgery was 64 d (32-141). Median number LN resected were 11 (1-50). Overall, 25 (28%) pts achieved pCR; 6/89 (7%) pts had positive circumferential resection margin. 25 (74%) patients in group 1 compared to 28 (51%) pts in group 2 underwent sphincter preserving surgery (P=0.045). Eight (24%) pts in group 1 and 17 (31%) in group 2 achieved pCR (P=0.479). The median TRG in group 1 was 2.5 and in group 2 was 2 (P=NS). In pts who achieved pCR, median TD was 67 d compared to 63 d in pts who did not achieve pCR. Of the 16 pts with signet histology 4(25%) had pCR compared to 21(29%) in those with non-signet histology (P=NS). Conclusions: We conclude that the timing of surgery is not an important variable post completion of NACTRT and our data suggests that it's possible that earlier surgery may be better for organ conservation. There is no incremental benefit of delaying the surgery though this needs to be confirmed in a prospective randomised trial.
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Ahmed, S., MA Rahim, M. Moniruzzaman, MA Khatun, FN Jahan i R. Akter. "Effect of Bulb Sizes on the Seed Yield of Two Onion (Allium Cepa L.) Varieties". SAARC Journal of Agriculture 18, nr 2 (4.01.2021): 51–65. http://dx.doi.org/10.3329/sja.v18i2.51108.
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An experiment was carried out at Horticulture Farm of Bangladesh Agricultural University, Mymensingh during the period from October 2018 to March 2019 to examine the effects of different bulb size viz., large size bulb (15±1 g), medium size bulb (10±1 g), small size bulb (7±1 g) on seed production of two onion varieties (Taherpuri and Kalash Nagari). Significant variation observed in both varieties for most of the parameters based on onion bulb size. The variety Kalash Nagari showed better performances compared to variety Taherpuri. After 60 days of planting, Kalash Nagari variety gave the highest plant height (55.07 cm), number of leaves (20.62), stalk length (100.78 cm), and total seed yield (630 kg ha-1), while in Taherpuri plant height, leaf number, stalk length and total seed weight were 32.21 cm, 6.93, 61.47 cm and 270 kg ha-1, respectively. Large sized bulb gave better performance compared to small sized bulb. The large sized bulb gave highest plant height (49.83 cm) and highest total seed yield (490 kg ha-1). Medium size bulb gave the seed yield (460 kg ha-1) and lowest in small size bulb (390 kg ha-1). Seed yield was significantly affected by the combined effects of variety and bulb size. Kalash Nagari onion with large sized bulb gave the highest seed yield (660 kg ha-1) and Taherpuri variety with small sized bulb gave the lowest seed yield (180 kg ha-1).
SAARC J. Agri., 18(2): 51-65 (2020)
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Gorban, V. V., V. S. Menshikh i E. V. Gorban. "Gender and age-specific eating behaviour in urban populations at risk of chronic noncommunicable diseases: an observational cohort study". Kuban Scientific Medical Bulletin 29, nr 1 (25.01.2022): 32–47. http://dx.doi.org/10.25207/1608-6228-2022-29-1-32-47.
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Background. Nonrational nutrition is among main risk factors of chronic noncommunicable diseases (CNCDs) that can be contained via adopting and motivating population to a healthy diet by clarifying territorial, gender and age-specific eating behaviours.Objectives. A study of urban gender and age-specific eating behaviours associated with universal and metabolic CNCD risk factors.Methods. An observational cohort study has been conducted with 1,317 urban residents (657 men and 660 women) aged 18–74 years at Kuban State Medical University, Ministry of Health of the Russian Federation, using anonymous surveys on food preferences, tobacco and alcohol consumption, physical activity (PA), as well as physical examination, anthropometry, electrocardiography (ECG) and biochemical blood tests.Results. Urban residents revealed low-physical activity (PA) (88%), overweight and obesity (33%), high tobacco (65%) and alcohol use (39%) in men, high metabolic risk by waist/hip circumference (33.7%) and significant polymorbidity in hypertension (3 to 8 diseases per person). The urban dietary pattern can be described “intermediate” by the co-presence of rational and nonrational ingredients in diet. Rational ingredients prevailed in women and elderly people. Elevated total cholesterol, low-density lipoproteins, triglycerides, gamma-glutamyl transpeptidase, alanine aminotransferase, aspartate aminotransferase, bilirubin, uric acid, urea, creatinine and ultra-sensitive C-reactive protein in blood were associated with foods intake like chips and breadsticks, potatoes, sweet drinks, confectionery and borscht.Conclusion. Adopting measures to rational nutrition in population may comprise a clear declaration of dysmetabolic nature of specific foods, eating behaviour monitoring and motivated self-control of body mass index and waist girth beyond medical check-ups.
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Mead, Nicola, Robert Varnam, Anne Rogers i Martin Roland. "What Predicts Patients' Interest in the Internet as a Health Resource in Primary Care in England?" Journal of Health Services Research & Policy 8, nr 1 (styczeń 2003): 33–39. http://dx.doi.org/10.1177/135581960300800108.
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Objectives: To identify what factors predict patients' interest in using Internet health information in the light of poor uptake of a free, guided Internet service in one inner-city general practice. Methods: Questionnaires were administered over a five-day period to consecutive adult patients attending two Manchester general practices: An inner-city practice serving a relatively deprived patient population where the free Internet service had previously been available, and a suburban practice serving a relatively affluent population. Data were analysed using multiple regression to identify predictors of self-reported interest in using the Internet for health information. Results: A total of 753 (74%) patients completed the questionnaire although analyses were restricted to 660 (65%) cases. Independent predictors of patient-reported interest in getting health information from the Internet were (in order of relative ‘importance’): Positive outcome expectancy (i.e. the patient's strength of belief that it would enable them to deal better with their health); previous use of health websites; positive ‘self-efficacy’ (i.e. patients' confidence in their ability to use the technology); higher education; a positive attitude to getting health information from alternative sources; social deprivation; and having school-age children living at home. Level of Internet access was an important determinant of self-efficacy, but home access was the key predictor of outcome expectancy and past use of ‘e-health’. Conclusions: Access, demographics and, particularly, motivational factors all influence patients' interest in the Internet as a health resource. Proposals to encourage more widespread use of digital health information need to take account of this complexity and not deal with access issues alone.
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McIsaac, Warren J., Tony Mazzulli, Joanne Permaul, Rahim Moineddin i Donald E. Low. "Community-Acquired Antibiotic Resistance in Urinary Isolates from Adult Women in Canada". Canadian Journal of Infectious Diseases and Medical Microbiology 17, nr 6 (2006): 337–40. http://dx.doi.org/10.1155/2006/791313.
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BACKGROUND:There are currently limited data regarding the prevalence of antimicrobial-resistant organisms causing community-acquired urinary tract infections among adult women in Canada. Trimethoprim-sulfamethoxazole (TMP-SMX) is the recommended first-line empirical antibiotic treatment, unless resistance ofEscherichia colito TMP-SMX exceeds 20%.OBJECTIVE:To assess current levels of TMP-SMX-resistantE coliin community-acquired cases of urinary tract infection in adult women.METHOD:Assessment of urine culture reports obtained from 21 laboratories across Canada, submitted by family physicians for women aged 16 years and older.RESULTS:In 2199 adult women with a positive urine culture, 1079 (49.1%) of pathogens isolated were resistant to at least one antibiotic and 660 (30.0%) were multidrug-resistant (resistant to two or more antibiotics). TMP-SMX resistance was seen in 245 of 1613 (15.2%)E coliisolates (95% CI 13.5 to 17.0). This proportion was higher in women 50 years of age and older (155 of 863 isolates [18.0%]; P=0.001), in British Columbia (70 of 342 isolates [20.5%]) and in Ontario (62 of 370 isolates [16.8%]) when compared with eastern provinces (65 of 572 isolates [11.4%]; P=0.001). Fluoroquinolone-resistantE colioccurred in 107 of 1557 (6.9%) isolates (95% CI 5.7 to 8.2), with the highest level found in British Columbia (54 of 341 isolates [15.8%]; P=0.001).CONCLUSION:TMP-SMX continues to be appropriate as first-line empirical treatment of acute cystitis in adult women in Canada, as resistance remains below 20%. However, TMP-SMX resistance is higher in older women and in some provinces. The level of fluoroquinolone-resistantE coliis highest in British Columbia.
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Hisatome, Ichiro, Takayuki Morisaki, Hiroshi Kamma, Takako Sugama, Hiroko Morisaki, Akira Ohtahara i Edward W. Holmes. "Control of AMP deaminase 1 binding to myosin heavy chain". American Journal of Physiology-Cell Physiology 275, nr 3 (1.09.1998): C870—C881. http://dx.doi.org/10.1152/ajpcell.1998.275.3.c870.
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AMP deaminase (AMPD) plays a central role in preserving the adenylate energy charge in myocytes following exercise and in producing intermediates for the citric acid cycle in muscle. Prior studies have demonstrated that AMPD1 binds to myosin heavy chain (MHC) in vitro; binding to the myofibril varies with the state of muscle contraction in vivo, and binding of AMPD1 to MHC is required for activation of this enzyme in myocytes. The present study has identified three domains in AMPD1 that influence binding of this enzyme to MHC using a cotransfection model that permits assessment of mutations introduced into the AMPD1 peptide. One domain that encompasses residues 178–333 of this 727-amino acid peptide is essential for binding of AMPD1 to MHC. This region of AMPD1 shares sequence similarity with several regions of titin, another MHC binding protein. Two additional domains regulate binding of this peptide to MHC in response to intracellular and extracellular signals. A nucleotide binding site, which is located at residues 660–674, controls binding of AMPD1 to MHC in response to changes in intracellular ATP concentration. Deletion analyses demonstrate that the amino-terminal 65 residues of AMPD1 play a critical role in modulating the sensitivity to ATP-induced inhibition of MHC binding. Alternative splicing of the AMPD1 gene product, which alters the sequence of residues 8–12, produces two AMPD1 isoforms that exhibit different MHC binding properties in the presence of ATP. These findings are discussed in the context of the various roles proposed for AMPD in energy production in the myocyte.
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Asgher, Muhammad, i Hafiz Muhammad Nasir Iqbal. "Characterization of a novel manganese peroxidase purified from solid state culture of Trametes versicolor IBL-04". BioResources 6, nr 4 (8.09.2011): 4317–30. http://dx.doi.org/10.15376/biores.6.4.4317-4330.
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A novel manganese peroxidase (MnP) produced by an indigenous white rot fungal strain Trametes versicolor IBL-04 in solid state medium of corncobs was purified and characterized. The fungus produced 964U/mL MnP in the presence of additional carbon (glucose) and nitrogen (yeast extract) supplements added at a C:N ratio of 25:1, 1mM Tween-80 (1mL), 1mM MnSO4 (1mL), and 1mM CuSO4 (1mL). The MnP was purified by ammonium sulfate fractionation (65% saturation) and dialysis, followed by Sephadex G-100 gel filtration chromatography. Purification procedures resulted in 2.4-fold purification with an overall yield and specific activity of 3.4% and 660 U/mg, respectively. The purified MnP was monomeric of molecular weight of 43 kDa, showing a single band on sodium dodecyl sulfate poly acrylamide gel electrophoresis (SDS-PAGE). The enzyme was optimally active at pH 5 and 50oC and was stable for 1 h over a broad range of pH (4-7) and temperature (40-65oC). Kinetic constants KM and Vmax of purified MnP were 70 µM and 540 U/mL for MnSO4 substrate. The effect of possible activators and inhibitors of enzyme were also investigated, and it was observed that EDTA, Cystein, and Ag+ caused MnP inhibition and inactivation to different extents, whereas MnP was activated by 4 and 3 mM of Cu2+ and Fe2+, respectively. High thermo-stability, low KM and high Vmax features of this novel MnP isolated from culture filtrate of T. versicolor IBL-04 suggests its suitability for various industrial and biotechnological applications.
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Manjari, Lydia S. Jasmine Beryl, Atreyee Sinha, Ashutosh Tripathi i Karuna D. Sagil. "Impact of Strategic Adaptations Due to COVID-19 Pandemic on a Capacity Building Program: Insights From a DRTB Program Under NTEP in India". SAARC Journal of Tuberculosis, Lung Diseases and HIV/AIDS 20, nr 1 (31.12.2022): 8–16. http://dx.doi.org/10.3126/saarctb.v20i1.52661.
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Introduction: India has experienced high burden of drug resistant tuberculosis, under par treatment success rate and very high loss to follow-up despite continuous efforts to develop evidence-based policy to treat DRTB patients. However, it is challenging to translate policies into practice. The goal of this program was to build capacity of the program staff for effective management of DRTB in public sector through workshops, capacity building exercises, creation and dissemination of information, education and communication materials. Methodology: The program was implemented in seven states; 11 state-level kick-off trainings were planned to reach 660 National TB Elimination Program staffs. Due to COVID-19 pandemic, on-field activities were replaced with virtual trainings with a set of 4-5 webinars per state. Pre and post training assessments were done to evaluate uptake of knowledge. Number of trainings conducted, staff trained and knowledge improvement were the indicators used to assess the outcome. Results: A total of 34 webinars were conducted on revised Programmatic Management of Drug- Resistant Tuberculosis guidelines and 3000 staff was trained. The program organized three times more training and five times more staff were trained. Although retention of participants and their attention was challenging, transition to virtual platform provided increased coverage and targeted outputs. Proportion of participants answering correctly in pre/post-training assessments, increased from 47% to 65%. Conclusion: Use of virtual trainings is an efficient high yielding method to build capacity of NTEP staff. Lessons learnt can help improve such interventions, benefit health programs and the end beneficiaries - the patients.
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Brodovskaya, Ekaterina P., Larisa А. Tararina, Mikhail N. Zharkov, Irina A. Khutorskaya, Denis E. Yakobson, Amina Al-khadj Aioub, Igor V. Maev i in. "Polyelectrolyte Microcapsules as a Tool to Enhance Photosensitizing Effect of Chlorin E6". Research Results in Pharmacology 9, nr 4 (15.11.2023): 43–51. http://dx.doi.org/10.18413/rrpharmacology.9.10055.
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Introduction: Photodynamic therapy is a promising method of tumors treatment using photosensitizers and light of a certain wavelength. PS modification improves and enhances the phototoxic effect with decreased dark cytotoxicity. Materials and Methods: We compared the photosensitizing effect of polyelectrolyte microcapsules with chlorin E6 (ClE6) and free ClE6 at equivalent concentrations on murine fibroblast culture L929 using in vitro tests. Microcapsules were prepared layer by layer, sequentially depositing oppositely charged polyelectrolytes onto spherical CaCO3 particles. Cellular uptake of capsules was assessed using confocal microscopy. MTT test was used for a study of cell viability, and the relative amount of ROS was determined by the fluorescent method. Results: Microcapsules with ClE6 (in all tested concentrations) after exposure to red light (660 nm) reduced cell viability from 20% to 5%, while these capsules did not have dark cytotoxicity. Free ClE6 at the same concentrations as in the capsules after irradiation reduced viability from 65% to 35%. The level of ROS in the group of cells with capsules was 2 times higher compared to the group with CLE6. Discussion: The most probable mechanism of toxicity increase is creation of a higher ROS concentration and effect localization in the area of microcapsule interaction with the cell membrane. ROS production activation may stem from capsules providing a higher local PS concentration in the cell or nearby than the drug’s free form. Conclusion: The inclusion of chlorin E6 in polymer capsules reduced dark toxicity and increased the photosensitizing effect compared to the free form of ClE6.
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Zhuang, B. L., T. J. Wang, J. Liu, Y. Ma, C. Q. Yin, S. Li, M. Xie i in. "Absorption coefficient of urban aerosol in Nanjing, west Yangtze River Delta of China". Atmospheric Chemistry and Physics Discussions 15, nr 12 (16.06.2015): 16175–213. http://dx.doi.org/10.5194/acpd-15-16175-2015.
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Abstract. Absorbing aerosols can significantly modulate shortwave solar radiation in the atmosphere, affecting regional and global climate. Aerosol absorption coefficient (AAC) is an indicator to assess the impact of absorbing aerosols on radiative forcing. In this study, the near-surface AAC and absorption angstrom exponent (AAE) in urban Nanjing, China, are characterized on the basis of measurements in 2012 and 2013 using the 7-channel Aethalometer (model AE-31, Magee Scientific, USA). The AAC is estimated with direct and indirect corrections, which show consistent temporal variations and magnitudes of AAC at 532 nm. The mean AAC at 532 nm is about 43.23 ± 28.13 M m−1 in urban Nanjing, which is much lower than that in Pearl River Delta and as the same as that in rural areas (Lin'an) in Yangtze River Delta. The AAC in urban Nanjing shows strong seasonality (diurnal variations), high in cold seasons (at rush hours) and low in summer (in afternoon). It also show synoptic and quasi-two-week cycles in response to weather systems. Its frequency distribution follows a typical lognormal pattern. The 532 nm-AAC ranging from 15 to 65 M m−1 dominates, accounting for more than 72% of the total data samples in the entire study period. Frequent high pollution episodes, such as those observed in June 2012 and in winter 2013, greatly enhanced AAC and altered its temporal variations and frequency distributions. These episodes are mostly due to local emissions and regional pollutions. Air masses from northern China to Nanjing can sometimes be highly polluted and lead to high AAC at the site. AAE at 660/470 nm from the Schmid correction (Schmid et al., 2006) is about 1.56, which might be more reasonable compared to that from the Weingartner correction (Weingartner et al., 2003). Low AAEs mainly appear in summer in response to the relative humidity (RH). AAC increases with increasing AAE at a fixed aerosol loading. The RH-AAC relationship is more complex. Overall, AAC peaks around RH values of 40% (1.3 < AAE < 1.6), 65% (AAE < 1.3 and AAE > 1.6), and 80% (1.3 < AAE < 1.6).