Gotowa bibliografia na temat „541.3/7”

Background. Enteroatmospheric fistulas (EAF) that occur during the use of the “open abdomen” surgical tactics are a complex surgical pathology with a high mortality rate.The aim. To assess the effectiveness of treatment of various forms of enteroatmospheric fistulas in patients with postoperative peritonitis using vacuum aspiration technology.Methods. We assessed the results of the surgical treatment of 46 patients with EAF in the late course of postoperative peritonitis (PP). Three clinical and morphological groups were distinguished: group 1 (n = 24) – EAF in small wounds of the anterior abdominal wall; group 2 (n = 15) – EAF opening into limited cavities; group 3 (n = 7) – EAF opening into laparostoma wounds. In group 1, a fistula was formed using continuous aspiration devices or VAC systems. In group 2, we used continuous aspiration of intestinal contents from the cavity. In group 3, laparostoma was treated using vacuum devices with isolation of the intestinal fistula and simulation of a floating enterostoma.Results. Group 3 of patients with EAF was characterized by a high flow rate (1224.2 ± 210.3 ml), duration of treatment (87.3 ± 12.5 day), extensive laparostoma (335.4 ± 14.3 сm2), high mortality rate (57.1 %). The best results of treatment were obtained in groups 1 and 2. The flow rate was 675.8 ± 154.3 and 541.3 ± 114.1 ml, the duration of treatment was 2 or 3 times less (37.7 ± 6.1 and 26.4 ± 5.2 days), the mortality rate was 8.3 % and 6.7 % respectively.Conclusion. EAF that occur when using the “open abdomen” surgical tactics due to the impossibility of their isolation in extensive wounds of the anterior abdominal wall are complicated clinical and morphological forms. For their treatment, it is advisable to use VAC systems, aimed at the treatment of both the anterior abdominal wall wound itself and the intestinal fistula opening into it for its gradual extraterritorialization by modeling a floating enterostoma in a vacuum device.

The purpose of this research was to examine the reliability and validity of Bull’s Mental Skills Questionnaire (BMSQ), measuring seven psychological skills resulting in a total scale score, within Turkey. The sample consisting of 163 males and 131 females, totaling 294 athletes, completed the 28 item BMSQ. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were undertaken. EFA results yielded a satisfactory seven-factor solution, the same as the English version. Cronbach alpha (α) reliability indices were as follows: concentration ability (0.71), anxiety and worry management (0.63), relaxation ability (0.69), imagery ability (0.73), self-confidence (0.72), motivation (0.64) and mental preparation (0.52). The BMSQ explained 62% of the total variance. Moreover, model fit indices calculated during CFA for the 28 item and 7 sub-dimensions model of BMSQ indicated an acceptable fit [Chi-Square (ꭓ²)=541.2, df=328, ꭓ²/df=1.65, Root Mean Square Error Approximation (RMSEA)=0.05, Comparative Fit Index (CFI)=0.95, Goodness of Fit Index (GFI)=0.90, Normed Fit Index (NFI)=0.89, and Non Normed Fit Index (NNFI)=0.90]. Thus, the original 7-factor solution was supported with the data collected from Turkish participants. Results demonstrated that the BMSQ is a valid and reliable instrument for the Turkish population.

Engineered nanoparticles that have distinctive targeted characteristics with high potency are modernistic technological innovations. In the modern era of research, nanotechnology has assumed critical importance due to its vast applications in all fields of science. Biologically synthesized nanoparticles using plants are an alternative to conventional methods. In the present study, Citrullus colocynthis (bitter apple) was used for the synthesis of gold nanoparticles (AuNPs). UV-Vis’s spectroscopy, XRD, SEM and FTIR were performed to confirm the formation of AuNPs. UV-Vis’s spectra showed a characteristic peak at the range of 531.5–541.5 nm. XRD peaks at 2 θ = 38°, 44°, 64° and 77°, corresponding to 111, 200, 220 and 311 planes, confirmed the crystalline nature of AuNPs. Spherical AuNPs ranged mostly between 7 and 33 nm, and were measured using SEM. The FTIR analysis confirmed the presence of phytochemicals on the surface of AuNPs. Successful synthesis of AuNPs by seed extract of Citrullus colocynthis (bitter apple) as a capping and reducing agent represents the novelty of the present study.

ABSTRACT Ertapenem (INVANZ) is a new once-a-day parental β-lactam antimicrobial agent that has been shown to be highly effective as a single agent for treatment of various community-acquired and mixed infections. The plasma pharmacokinetics of a 1-g intramuscular (i.m.) dose was compared with those of a 1-g intravenous (i.v.) dose infused over 30 min, the recommended rate of i.v. infusion for comparison, and over 120 min, which more closely mimicked the time course for absorption of the i.m. form. In a three-period crossover study (Part A), 26 healthy subjects received single doses of ertapenem administered i.m., i.v. infused over 30 min, and i.v. infused over 120 min. Blood for ertapenem analysis was collected over 24 h postdose for each treatment. In Part B, these fasted subjects received a 1-g i.m. dose of ertapenem once daily for 7 days. Following a 1-g i.m. dose and a 1-g i.v. dose infused over 120 min, the geometric mean area under the concentration curve from hour 0 to infinity (AUC0-∞) was 541.8 μg · hr/ml following i.m. administration and 591.4 μg · hr/ml following a 120-min infusion; the geometric mean ratio was 0.92 with a 90% confidence interval of 0.88 to 0.95. The geometric mean AUC0-∞ was nearly identical when 1-g doses were infused over 30 or 120 min. Although the maximum concentration of drug in serum was somewhat lower following i.m. administration than following i.v. administration, the shape of the plasma concentration profiles was roughly comparable at later time points. Ertapenem did not accumulate after multiple 1-g i.m. daily doses over 7 days. The geometric mean ratio for AUC0-24 (day 7/day 1) was 0.98 with a 90% confidence interval of 0.94 to 1.02. Thus, the relative bioavailability of the 1-g i.m. dose was 92%. Ertapenem does not accumulate following multiple daily 1-g i.m. doses over 7 days.

Glyphosate (GLY), the active substance in non-selective herbicides, is often found in ruminant feed. The present feeding study aimed to investigate the effects of GLY-contaminated rations and different concentrate feed proportions (CFP) on the health of fattening German Holstein bulls. Bulls were grouped by low (LC) or high (HC) CFP with (GLYLC, GLYHC) or without GLY-contaminations (CONLC, CONHC) in their rations. Intakes (dry matter, water) and body weight were documented continuously lasting over an average range from 392.2 ± 60.4 kg to 541.2 ± 67.4 kg (mean ± SD). Blood samples collected at the trial’s beginning, and after 7 and 15 weeks, were analyzed for hematological and clinical-chemical traits, functional properties of leukocytes, redox parameters and DNA damage. The average GLY exposures of 128.6 (GLYHC), 213.7 (GLYLC), 1.3 (CONHC) and 2.0 µg/kg body weight/d (CONLC) did not lead to GLY effects for most of the assessed parameters relating to animal health and performance. CFP and time displayed marked influences on most of the experimental parameters such as higher dry matter intake and average daily gain in HC compared with the LC groups. GLY effects were rather weak. However, the observed interactive effects between GLY and CFP and/or time occurring in an inconsistent manner are likely not reproducible. Finally, all animals remained clinically inconspicuous, which brings into question the physiological relevance of putative GLY effects.

El estudio de las características involucradas en el crecimiento y los efectos ambientales que son responsables de su variación en ganado Blanco Orejinegro (BON) son de gran importancia para estimular la cría y evitar su extinción. Los objetivos de este trabajo fueron describir las características de crecimiento en ganado BON y determinar la influencia de algunos factores ambientales sobre estas variables. Se comprobó información de 3218, 2264, 496, 2287, 325 y 408 registros para peso al nacimiento (PN); peso al destete (PD); peso al año (PA); ganancia diaria de peso al destete (GDP); tiempo para alcanzar 120 kg (T120); y tiempo para alcanzar 60 % de peso adulto (T60 %), respectivamente. Se realizaron ANAVAs para determinar la influencia de los factores número de parto (NP), sexo, época, edad al pesaje y grupo contemporáneo (GC). Las medias fueron 31.8 kg, 201.9 kg, 230.5 kg, 0.645 kg/día y 136.4 y 541.1 días, para PN, PD, PA, GDP, T120 y T60 %, respectivamente. Los efectos de NP (excepto para T60 %), GC, sexo y edad al pesaje fueron significativos, pero no la época del año en que se hizo el pesaje. En media, se encontró que animales hijos de vacas con NP 1 o 7 fueron significativamente más livianos; el GC mostró ser una fuente de variación importante debido a la interacción entre sexo-año-hato o hato-año. Estos resultados muestran que algunos factores ambientales afectan el crecimiento en la población BON y que esta es una raza con buen potencial productivo.

Objectives: Reye’s syndrome is a rare and potentially fatal illness that is defined as encephalopathy accompanied by liver failure. The aim of this study was to assess Reye’s syndrome profiles by analyzing data from the spontaneous reporting system database. Methods: We analyzed reports of Reye’s syndrome using the US Food and Drug Administration Adverse Event Reporting System and the Japanese Adverse Drug Event Report databases. The reporting odds ratio and proportional reporting rate were used to detect the pharmacovigilance signal. Results: The US Food and Drug Administration Adverse Event Reporting System contains 12,201,620 reports from January 2004 to June 2020, of which 186 are on Reye’s syndrome. The Japanese Adverse Drug Event Report contains 646,779 reports from April 2004 to September 2020, of which 30 are on Reye’s syndrome. In the US Food and Drug Administration Adverse Event Reporting System database, the reporting odds ratios (95% confidence interval, number of cases) of aspirin, diclofenac, ibuprofen, acetaminophen, and valproate sodium were 404.6 (302.6–541.0, n = 80), 15.1 (6.7–34.1, n = 6), 26.2 (16.1–42.6, n = 18), 10.7 (5.5–20.9, n = 9), and 47.1 (26.2–84.6, n = 12), respectively. In the Japanese Adverse Drug Event Report database, the reporting odds ratios (95% confidence interval, number of cases) of aspirin, diclofenac, ibuprofen, loxoprofen, acetaminophen, and valproate sodium were 14.1 (5.4–36.8, n = 5), 51.7 (22.2–120.5, n = 7), 135.0 (40.8–446.2, n = 3), 17.6 (6.7–46.0, n = 5), 24.0 (9.2–62.6, n = 5), and 13.8 (3.3–57.9, n = 2), respectively. The reported number of female patients aged 30–39 years was the highest in the Japanese Adverse Drug Event Report. Conclusion: Although the frequency of the occurrence of Reye’s syndrome is low, the possible risk of the disease occurring in adult females should be considered.

Abstract Introduction Chronic myeloid leukemia is a myeloproliferative neoplasm (MPN) that is characterized by the uncontrolled production of mature and maturing granulocytes, mainly neutrophils. The molecular defect in CML is related to the reciprocal translocation between chromosomes 9 and 22, resulting in the BCR-ABL1 fusion gene. Typically, CML is BCR-ABL1 positive. Mutation like JAK2, which is seen in BCR-ABL1 negative MPN is usually absent in CML. However, there is an uncommon entity of CML which has been reported to have both BCR-ABL1 positive and JAK2 mutation concomitantly. Little is known about the characteristics of the best treatment modalities and the outcome of CML with double-positive ( JAK2 and BCR-ABL1). Methods We searched the English literature (Google Scholar, PubMed, and SCOPUS) for studies, reviews, case series, and case reports of patients with chronic myeloid leukemia who had JAK2 mutation. Inclusion criteria: were the presence of JAK2 mutation in CML patients with BCR-ABL1 rearrangement and, secondly, age ≥18yrs. The search included all articles published up to 20th April 2021. Results and Discussion A total of 25 patients met our criteria of search. Twenty-two patients were diagnosed in the chronic phase, 2 patients in the accelerated phase, and one patient transformed to the blast phase. More females n=16 and 10 males. The mean age at the time of diagnosis was 61.3 years. 9 patients had to be switch to a second-line therapy. 7 patients were treated with imatinib; only 1 patient has loss of JAK2 mutation with imatinib (1 out of 7). While 3 patients treated with dasatinib 2 responded, and one 1 had persistent JAK2 mutation. The reason for detecting the JAK2 mutation was persistent thrombocytosis or erythrocytosis, failure to respond to treatment, or suspected other MPN. Hematological parameters appear close to other CML; patients with mean WBC 56.8 x10^3/uL, mean PLT of 541.9 x10^3/uL, and mean Hb of 12.4 g/dl. The characteristics of age and gender for this category of patients with CML are not significantly different from other CML patients. Age and gender distribution and the presence of splenomegaly or organomegaly are almost the same. Males were slightly more than females as CML has a slight male predominance. The mean age was 58 years, which is close to the mean age of CML patients. From the data available, most patients treated with dasatinib had the JAK2 mutation undetectable on follow-up, while patients on imatinib JAK2 mutation persisted despite that some had CML in remission. This might means that the driving mutation is probably BCR-ABL. Regarding the response to the TKI 3 patients who had dasatinib 2 had a loss of JAK2 and one JAK2 persisted. Only one patient on imatinib had a loss of JAK2 out of 7. The reason behind the high success rate of achieving remission with medication like dasatinib could be explained by the drug's dual tyrosine kinase inhibitors activity. Imatinib acts by inhibiting the BCR-ABL1 pathway, inhibiting the tyrosine kinase by competitive inhibition, blocking the ATP binding site, and thereby preventing the conformational switch to the active form [0]. In comparison, a broad-spectrum kinase inhibitors (less selective) like dasatinib is (a second-generation tyrosine kinase inhibitor) inhibiting the BCR-ABL1 like imatinib, and additionally, they inhibit other signaling pathways like SRC kinases. This may allow multikinase inhibitors to have additional therapeutic effects that can include the JAK2 mutation. Patients with BCR-ABL-JAK2 Positive Chronic Myeloid Leukemiahave the same characteristics of BCR-ABL CML, and also they share some features like persistence of thrombocytosis. Conclusion It is difficult to conclude that multi-kinase inhibitors are superior to imatinib in treating CML with concomitant JAK2 mutation. But the result of the reported cases showed that multi-kinase inhibitors are more likely to be successful in achieving remission and loss of JAK2 mutation. However, it is difficult to generalize the result without further studies due to the few numbers of patients and the unusual association. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

Abstract In this paper, we use random forest feature extraction to classify and rank the importance of the behavioral features in the student behavior dataset and obtain the behavioral features with top importance. In the knowledge tracking model, the multidimensional feature strategy is integrated, and the attention weight is introduced in the prediction stage, respectively, so as to predict the results of students’ spatiotemporal behavioral prediction behavioral prediction. The results show that the dormitory area activity has the highest percentage of 30.27%, followed by the teaching area and dining hall area activities. Rest > Study > Eat reflects the regularity of students’ behavior. Behaviors vary at different times of the day. From 0:00 to 7:00, most behaviors are related to rest, while from 8:00 to 11:00, behaviors related to class and eating are predominant. Attending classes abnormally only happened in the second week (3%) and the third week (5%). In the prediction of consumption behavior, the sixth type of students, the average monthly consumption is shallow (541.34) and less frequent (249), and teachers should pay more attention to the life of these students and intervene in the education of mental and physical health.

Abstract This study’s purpose is to assess the stress distribution in the peri-implant bone, implants, and prosthetic framework using two different posterior implant angles. All-on-four maxillary prostheses fabricated from feldspathic-ceramic-veneered zirconia-reinforced lithium silicate (ZLS) and feldspathic-ceramic-veneered cobalt-chromium (CoCr) were designed with 17 or 30-degree-angled posterior implants. Posterior cantilever and frontal vertical loads were applied to all models. The distribution of maximum and minimum principal stresses (σmax and σmin) and von Mises stress (σVM) was evaluated. Under posterior cantilever load, with an increase in posterior implant angle, σmax decreased by 4 and 7 MPa in the cortical bone when ZLS and CoCr were used as a prosthetic framework, respectively. Regardless of the framework material, 17-degree-angled posterior implants showed the highest σVM (541.36 MPa under posterior cantilever load; 110.79 MPa under frontal vertical load) values. Regardless of the posterior implant angle, ZLS framework showed the highest σVM (91.59 MPa under posterior cantilever load; 218.99 MPa under frontal vertical load) values. Increasing implant angle from 17 to 30° caused a decrease in σmax values in the cortical bone. Designs with 30-degree posterior implant angles and ZLS framework material may be preferred in All-on-four implant-supported fixed complete dentures.