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Janati, Hicham. "Advances in Optimal transport and applications to neuroscience". Electronic Thesis or Diss., Institut polytechnique de Paris, 2021. http://www.theses.fr/2021IPPAG001.
Pełny tekst źródłaBrain imaging devices can provide a glimpse at neural activity in multiple spatial locations and time points. Moreover, neuroimaging studies are usually conducted for multiple individuals undergoing the same experimental protocol. Inferring the underlying sources is a challenging inverse problem that can only be tackled by biasing the solutions with prior domain knowledge. Several prior hypotheses have been pursued in the literature such as promoting sparse over dense solutions or solving the problem for multiple subjects at once. However, none take advantage of the particular spatial geometry of the problem. The purpose of this thesis is to exploit the multi-subject, spatial and temporal aspects of magneto-encephalography data as much as possible to improve the conditioning of the inverse problem. To that end, our contributions revolve around three axes: optimal transport (OT), sparse multi-task regression and time series. Indeed, the ability of OT to capture spatial disparities between measures makes it very well suited to compare and average neural activation patterns based on their shape and location over the cortical surface of the brain. For the sake of scalability, we take advantage of the entropic formulation of optimal transport, which we argue has two important missing pieces. From a theoretical perspective, it has no closed form analytical expressions, and from a practical perspective, entropy leads to a significant increase in variance known as "entropic bias". We complete this puzzle by studying multivariate Gaussians for which we uncover an entropic OT closed form and propose "debiased" algorithms to compute fast and accurate optimal transport barycenters. Second, we define a multi-task prior based on OT and sparse penalties to jointly solve the inverse problem for multiple subjects to promote spatially coherent solutions. Our real data experiments highlight the benefits of using OT as a prior over classical multi-task regression penalties. Finally, we propose a loss function to compare and average spatio-temporal data that computes temporal alignments across spatially similar observations of the data via a fast GPU friendly algorithm
Dumenil, Sylvie. "Influence de concentrations subinhibitrices d'amikacine sur l'activité élastolytique de"Pseudomonas aeruginosa" IFO 3455". Paris 5, 1991. http://www.theses.fr/1991PA05P101.
Pełny tekst źródłaFarghal, Aser Soliman Ahmed. "Physiological MR imaging of small bowel : implementation, validation and interpretation". Thesis, University of East Anglia, 2011. https://ueaeprints.uea.ac.uk/34255/.
Pełny tekst źródłaHolmes, Christopher. "Economistic fallacies in contemporary capitalism : a Polanyian analysis of regimes of marketised social protection". Thesis, University of Warwick, 2010. http://wrap.warwick.ac.uk/34555/.
Pełny tekst źródłaEaton, Natasha Jane. "Imaging Empire : the trafficking of art and aesthetics in British India c.1772 to c.1795". Thesis, University of Warwick, 2000. http://wrap.warwick.ac.uk/34755/.
Pełny tekst źródłaChryssochoidis, George. "Rolling out new products across international markets : causes of delays". Thesis, University of Warwick, 1997. http://wrap.warwick.ac.uk/34655/.
Pełny tekst źródłaGoff, M. "A critical investigation of electronic patient records in the NHS in England : tracing an elusive object through its actor-network". Thesis, University of Salford, 2014. http://usir.salford.ac.uk/34355/.
Pełny tekst źródłaKaewkangsadan, Viriya. "Evaluation of immune cell infiltrates and expression of cytokines/biological molecules in the microenvironment of tumours and tumour-draining axillary lymph nodes in patients with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy : crucial contribution to immune-mediated tumour cell death". Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/34155/.
Pełny tekst źródłaMewar, Devesh. "Studies on autoantigens in rheumatoid arthritis". Thesis, University of Sheffield, 2003. http://etheses.whiterose.ac.uk/3455/.
Pełny tekst źródłaFreier, De Ferrari Luisa Feline. "A reverse migration paradox? : policy liberalisation and new south-south migration to Latin America". Thesis, London School of Economics and Political Science (University of London), 2016. http://etheses.lse.ac.uk/3455/.
Pełny tekst źródłaBarile, Giacomo. "Simulazione dello scenario di missione del volo inaugurale del lanciatore VEGA". Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amslaurea.unibo.it/3455/.
Pełny tekst źródłaWinter, Satine Hyacinth. "Navigating the battleground: autism policy and human rights for children with autism spectrum disorders in Australia". Thesis, Griffith University, 2017. https://doi.org/10.25904/1912/3455.
Pełny tekst źródłaPerella, Fiona M. "Exploring the experiences of fathers of children with a visible facial difference". Thesis, University of East London, 2013. http://roar.uel.ac.uk/3455/.
Pełny tekst źródłaSapienza, Maria Rosaria <1979>. "SNPs array karyotyping reveals recurrent lesions in primary myelofibrosis". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3455/.
Pełny tekst źródłaJain, Nibha. "Exploring interactive tangrams for teaching basic school physics". Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34755.
Pełny tekst źródłaSong, Jin E. "Hierarchical multiscale modeling of Ni-base superalloys". Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34855.
Pełny tekst źródłaAlsenani, Qusai. "The Role of hhbp in Heme Uptake in Haemophilus ducreyi". Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/34155.
Pełny tekst źródłaJin, Yongji. "Interactive Medical Record Visualization based on Symptom Location in a 2D Human Body". Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34255.
Pełny tekst źródłaBlais, Mario. "Conscience de soi et langage interne". Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34555.
Pełny tekst źródłaAl-Sadoon, Zaid. "Seismic Retrofitting of Conventional Reinforced Concrete Moment-Resisting Frames Using Buckling Restrained Braces". Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34755.
Pełny tekst źródłaKutcher, Stephen Alexander. "Investigating the Influence of NEDD4L in the Development of Salt Sensitive Hypertension with Age". Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34955.
Pełny tekst źródłaTravers, James Peregrine. "Studies relating to diabetic pregnancy : effect of hyperglycaemia upon carbohydrate metabolism and insulin on growth in the rat embryo". Thesis, University of Leicester, 1989. http://hdl.handle.net/2381/34255.
Pełny tekst źródłaDevorak, Nicholas A. "Organizational analysis of energy manpower requirements in the United States navy". Monterey, California: Naval Postgraduate School, 2013. http://hdl.handle.net/10945/34655.
Pełny tekst źródłaThe Secretary of the Navy (SECNAV) directed NPS to establish energy-focused subspecialty codes (SSC) that will prepare officers to manage all aspects of energy. In response to this SECNAV directive NPS has developed four energy-focused degree plans in the areas of Operations Analysis, Financial Management, Mechanical and Electrical Engineering. An analysis of the current force structure requirements was necessary to assess and implement a new direction. At the present time, the Navy utilizes petroleum management officers as energy managers. Unfortunately, the Navy Officer Billet Classification (NOBC) Codes assigned to these officers do not translate into the identification of the billets being identified with the energy SSCs. Analysis shows a possible solution to this issue is to establish afloat and ashore general Energy NOBCs that could be assigned as either a primary or secondary NOBC Energy billets. Specifically, analysis shows the majority of NOBCs assigned to energy billets are from the Naval Operations (90009999) Field. Therefore, this research recommends the establishment of two Energy NOBCs to support future Fleet Energy Management Challenges.
Umar, Aminu Mohammed. "Nigeria and the Boko Haram sect: adopting a better strategy for resolving the crisis". Monterey, California: Naval Postgraduate School, 2013. http://hdl.handle.net/10945/34755.
Pełny tekst źródłaThe purpose of this thesis is to examine the growth and activities of the Boko Haram sect in Nigeria with the aim of suggesting a strategy for resolving the crisis. The thesis will focus on the evolution of the sect and the enabling environment that served to support its growth especially in the North East region of Borno, Yobe, and Adamawa States of Nigeria. This thesis will demonstrate that the present response of the government which is more focused on addressing the symptoms of terrorism, remains inadequate, and requires a strategy that addresses the root cause and symptoms of terrorism to resolve the crisis. Such a strategy involves a government-wide approach whereby the military expands its operations to limit the operating space for the sect, and the government simultaneously addresses the root causes of the crisis as well as the conditions that facilitated the growth of Boko Haram in North-Eastern Nigeria.
McMillan, Brian L. "A proposed guide for improving the organization and conduct of Procurement Management Review within the Marine Corps Field Contracting System". Thesis, Monterey, California: Naval Postgraduate School, 1990. http://hdl.handle.net/10945/34855.
Pełny tekst źródłaThis thesis analyzes the organization and conduct of the Procurement Management Review (PMR) program within the Marine Corps Field Contracting System. An attempt is made to identify, to the maximum extent possible, the goals, management philosophy, organization, and methods considered to be ideal for PMR by three sources: literature, previous studies, and contracting professionals. An analysis and comparison between this consensus and HQMC's current PMR policies and procedures, as well as field contracting personnel's perceptions of these policies and procedures is conducted to highlight similarities and differences, and to provide acquisition managers at HQMC with alternatives for improving current practices to optimize the effectiveness of the PMR program, given the Marine Corps Field Contracting System's peculiar acquisition needs and structure.
Neil, David Langley. "Allelic variation and mutation at human hypervariable minisatellite loci". Thesis, University of Leicester, 1994. http://hdl.handle.net/2381/34455.
Pełny tekst źródłaYarlett, Robert Thomas. "Quantifying the role of parrotfish in the production and cycling of carbonate in coral reef ecosystems". Thesis, University of Exeter, 2018. http://hdl.handle.net/10871/34655.
Pełny tekst źródłaAlkhalifa, Saad Fadhil Ramadhan. "2D materials for magnetic and optoelectronic sensing applications". Thesis, University of Exeter, 2018. http://hdl.handle.net/10871/34955.
Pełny tekst źródłaRobbins, Jennifer L. "The role of mismatch repair in mediating cellular sensitivity to cisplatin : the Escherichia coli methyl-directed repair paradigm". Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/34155.
Pełny tekst źródłaIncludes bibliographical references (v. 2, leaves 195-258).
The anticancer drug cisplatin is in widespread use but its mechanism of action is only poorly understood. Moreover, human cancers acquire resistance to the drug, which limits its clinical utility. A paradox in the field is how loss of mismatch DNA repair leads to clinical resistance to this widely used drug. The phenomenon of cisplatin tolerance in mismatch repair deficient cells was initially discovered in E. coli, where methylation deficient dam mutants show high sensitivity to cisplatin and dam mutants with an additional mutation in either of the mismatch repair genes mutS or mutL show near wildtype levels of resistance. A prevalent explanation for this observation is the abortive repair model, which proposes that in dam mutants, where the strand discrimination signal is lost, mismatch repair attempts futile cycles of repair opposite cisplatin-DNA adducts. Previous findings have supported this model to the extent that MutS, the E. coli mismatch recognition protein, specifically recognizes DNA modified with cisplatin. However it has recently been shown that MutS binding to cisplatin adducts may contribute to toxicity by instead preventing the recombinational repair of a cisplatin-modified substrate, and we have previously shown that recombination is an essential mechanism for tolerating cisplatin damage.
(cont.) In the present study, we examined the global transcriptional responses of wildtype, dam, dam mutS, and mutS mutant E. coli after treatment with a toxic dose of cisplatin. We also determined any dose-response at the transcriptional level of several SOS response genes and other genes involved in DNA repair by real time RT-PCR. Furthermore, we performed single-cell electrophoresis in order to determine the effect of mismatch repair on the level of double-strand break formation in cisplatin-treated cells. Our results show that Dam-deficient strains exhibit unique gene regulation that may be due to mismatch-repair induced DNA damage in the absence of adenine methylation. In addition, cisplatin treatment induces double-strand break formation and the SOS response in a dose-dependent manner, and both break formation and the SOS response are greatest in the hypersensitive dam mutant strain. The higher level of cisplatin-induced double-strand breaks in the dam mutant may be dependent on functional mismatch repair.
by Jennifer L. Robbins.
Ph.D.
Soontrapa, Chaiyod. "Design optimization and analysis of coated particle fuel using advanced fuel performance modeling techniques". Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/34455.
Pełny tekst źródłaIncludes bibliographical references (p. 154).
Modifying material properties provides another approach to optimize coated particle fuel used in pebble bed reactors. In this study, the MIT fuel performance model (TIMCOAT) was applied after benchmarking against the experiment results. The optimization study focuses on the fracture toughness of silicon carbide and Bacon anisotropy factor (BAF) of pyrocarbon. The variations on the silicon carbide toughness show that higher fracture toughness leads to a lower fuel failure probability, as expected. However, the results from the BAF variations reveal that a higher BAF lowers a fuel failure probability. This quite contradicts the generally believed notion that a higher BAF would increase fuel failures. In addition to the fuel design optimization, the failure characteristics of coated particle fuel are explained and the key factors influencing such characteristics are identified.
by Chaiyod Soontrapa.
S.M.
Chan, Kai Pak. "Stochasticity induced by electrostatic waves in magnetized plasma". Thesis, Massachusetts Institute of Technology, 1994. http://hdl.handle.net/1721.1/34055.
Pełny tekst źródłaIncludes bibliographical references (leaves 105-106).
by Kai Pak Chan.
B.S.
M.Eng.
Hall, Ralph P. 1975. "Understanding and applying the concept of sustainable development to transportation planning and decision-making in the U.S". Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/34555.
Pełny tekst źródłaIncludes bibliographical references.
This research demonstrates that sustainable development is a multidimensional concept that should be approached in a transdisciplinary manner. Its objective has been to synthesize and integrate disparate and currently unconnected lines of thought that have not yet been applied in a systematic way to promote sustainable development and sustainable transportation. The primary contribution of this research is the theoretical development of a decision-support framework that identifies the tools and approaches that decision-makers could/should use to create policies and programs that transition society towards sustainability. These tools and approaches are either articulated or developed by the author throughout the dissertation. Specific ideas explored include a Rawlsian/utilitarian decision-making philosophy; a hybrid trade-off/positional analysis framework that is presented as an alternative to benefit-cost analysis; ecological vs. environmental economics; participatory backcasting; and ways to stimulate disrupting and/or radical technological innovation. To identify gaps that exist between theory and practice, the approach embodied in the proposed sustainable transportation decision-support framework is compared with current metropolitan transportation planning and decision-making processes in the U.S. The framework is then used to consider how the U.S. federal government might move the nation's transportation system towards sustainability.
by Ralph P. Hall.
Ph.D.
Afergan, Michael Moïse. "Applying the repeated game framework to multiparty networked applications". Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/34655.
Pełny tekst źródłaIncludes bibliographical references (p. 145-154).
This thesis presents repeated game analysis as an important and practical tool for networked application and protocol designers. Incentives are a potential concern for a large number of networked applications. Well-studied examples include routing and peer-to-peer networks. To the extent that incentives significantly impact the outcome of a system, system designers require tools and frameworks to better understand how their design decisions impact these incentive concerns. Repetition is a prevalent and critical aspect of many networking applications and protocols. Most networked protocols and architectures seek to optimize performance over a longer timescale and many have explicit support for repetition. Similarly, most players in networked applications are interested in longer horizons, whether they be firms building a business or typical individuals trying to use a system. Fortunately, the study of repeated interaction between multiple self-interested parties, repeated games, is a well-understood and developed area of economic and game theoretic research. A key conclusion from that literature is that the outcome of the repeated game can differ qualitatively from that of the one-shot game. Nonetheless, the tools of repeated games have rarely if ever been brought to bear on networking problems. Our work presents the descriptive and prescriptive power of repeated game analysis by making specific contributions to several relevant networking problems.
(cont.) The applications considered are inherently repeated in practice, yet our research is the first to consider the repeated model for each particular problem. In the case of interdomain routing, we first show that user-directed routing (e.g., overlays) transforms routing into a meaningfully repeated game. This motivates us to consider protocols that integrate incentives into routing systems. In designing such a routing protocol, we again use repeated games to identify important properties including the protocol period and the format of certain protocol fields. Leveraging this insight, we show how it is possible to address the problem of the repeated dynamic and arrive at a more desirable outcome. In the case of multicast overlay networks, we show how repeated games can be used to explain the paradox of cooperative user behavior. In contrast to prior models, our repeated model explains the scaling properties of these networks in an endogenous fashion. This enables meaningful examination of the impact architecture and protocol design decisions have on the system outcome. We therefore use this model, with simulation, to descry system parameters and properties important in building robust networks. These examples demonstrate the important and practical insights that repeated game analysis can yield. Further, we argue that the results obtained in the particular problems stem from properties fundamental to networked applications - and their natural relationship with properties of repeated games.
(cont.) This strongly suggests that the tools and techniques of this research can be applied more generally. Indeed, we hope that these results represent the beginning of an increased use of repeated games for the study and design of networked applications.
by Michael Moïse Afergan.
Ph.D.
Yang, Joel K. (Joel Kwang wei). "Fabrication of superconducting nanowire single proton detectors". Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/34355.
Pełny tekst źródłaIncludes bibliographical references (p. 81-85).
The future NASA Mars project will need an ultra-fast, highly sensitive photodetector to increase the bandwidth of free-space long-range communication, which is now done primarily using RF signals. Our original motivation in fabricating superconducting nanowire single-photon detectors (SN-SPD) is to fulfill this need. The SN-SPD's reported GHz counting rates [1] make it very attractive for this application. A new fabrication process for making SN-SPDs using hydrogen-silsesqioxane (HSQ), a high-resolution electron-beam lithography resist will be presented. An electron-beam proximity-effect correction program was developed to achieve nanowires with uniform linewidths, which is important for device performance. Finally, we present initial test results that show device functionality and performance. Our best device has a detection efficiency of [approx.] 10 % at 1064 nm photon wavelength at 2.1 K and a photon-induced voltage-pulse duration of [approx.] 3 ns.
by Joel K. Yang.
S.M.
Murdoch, Kimberly R. "Development of a robust work transfer iomplementation process". Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/34755.
Pełny tekst źródłaIncludes bibliographical references (p. 121-122).
The industry-wide need for a robust method of transferring the manufacturing of a component from one location to another is addressed in this thesis. Work transfer activities can be initiated due to a number of business reasons. These reasons include: reducing general operating costs, increasing asset utilization, and reducing overhead costs by leveraging manufacturing synergies. However, in order to fully realize the benefits of a work transfer activity, a robust work transfer process is needed to mitigate the risks associated with work transfer activities. In this thesis, the work transfer process is studied with specific concentration on the implementation phase of the work transfer. The overall objective is to propose and document a robust work transfer implementation process that improves the reliability with which work transfers are executed. The current work transfer process at The Boeing Company, in addition to the strategic and business decisions that initiate work transfers and the selection of manufacturing processes and technologies, serve as the starting point of the work and associated considerations. In developing this recommended work transfer process, robustness was addressed as the risks associated with the implementation of work transfer activities and subsequent risk mitigation activities were identified, in cooperation with key stakeholders, via a failure modes and effects analysis (FMEA). These risk mitigation activities were then integrated into the current work transfer process, and the resulting overall process was documented. This recommended process was then assessed by comparing it with the current work transfer process on the basis of time and cost. The results of this assessment
indicate that the recommended work transfer is an improvement over the current work transfer process. The recommended process is presented generically, and as such is flexible due to its adaptability to individual situations. When implementing the recommended work transfer process, it is suggested that the responsibility for and authority of the work transfer process be assigned to an individual to ensure adherence to and adoption of the process. System-level interactions of factors within a manufacturing system are also investigated and presented in this thesis. The results of this investigation illustrate the need to consider the potential long-term system-level results when making business decisions. Finally, the issue of manufacturing flexibility is discussed, and the consideration of manufacturing mobility during the design of manufacturing processes is suggested.
y Kimberly Robyn Murdoch.
S.M.
M.B.A.
Kaya, Ömür Sedat. "Evaluation and improvement of proactive customer notification in e-commerce environment". Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/34855.
Pełny tekst źródłaIncludes bibliographical references (p. 53).
The Internet, and thus e-commerce, both Business to Consumer (B2C) and Business to Business (B2B), has changed the way companies do business with each other and communicate with their customers. Because of the speed of the Internet, information transfer both among companies and between a company and its customers has become faster, albeit technologically more complex, in the e-commerce era. It has been a challenge for e-companies to develop creative, satisfying ways of communicating with their customers. After all, the Internet is approximately a decade old, and there has not been enough accumulation of knowledge about customer behavior. Unlike in conventional shopping where the customer takes the product with him/her or makes specific delivery arrangements in a specific geographical zone, in e-commerce the customer picks a specific delivery method from literally anywhere in the world at any time. This, of course, brings many logistical challenges for a successful delivery. Dell Computer Corporation, famous for its build-to-order and direct model, is one of the biggest e-commerce companies in the world and, thus, faces the challenges that any e- commerce company must confront, such as communicating with customers efficiently in a timely manner. Therefore, such logistical challenges that the e-commerce era has brought are not unique to Dell. One such challenge is effective communication with the customer after a shipment is just processed. This thesis focuses on finding best-of-breed technologies and applications in the proactive customer notification field through benchmarking.
(cont.) This thesis also offers a tool to evaluate various technology providers and to make decisions based on the analysis.
by Ömür Sedat Kaya.
S.M.
M.B.A.
Fraser, Sydney Gordon. "Cognitive and behavioural strategies in the management of suicidal behaviour". Thesis, University of Leicester, 1987. http://hdl.handle.net/2381/34655.
Pełny tekst źródłaClarke, Michael P. "Silylenes as intermediates in the 'direct synthesis'". Thesis, University of Leicester, 1989. http://hdl.handle.net/2381/34055.
Pełny tekst źródłaArrieta-Martinez, Melania. "Biochemical and rheological properties of waxy wheat flour dough". Thesis, Kansas State University, 2016. http://hdl.handle.net/2097/34455.
Pełny tekst źródłaDepartment of Grain Science and Industry
Yong-Cheng Shi
Jon Faubion
The rheological properties of two waxy and two normal wheat flours were investigated and the observed differences between them were explained by biochemical analysis. Protein analysis showed that waxy flour had lower polymeric to monomeric ratio (0.70 and 0.58 for waxy flour compared to 0.75 and 0.76 for normal flour) and higher gliadin content in waxy wheat dough (43.9 and 47.3 for waxy wheat dough compared to 41.0 and 41.7 for normal wheat dough). Waxy flour had high amounts of insoluble (IPP) and unextractable (UPP) polymeric protein despite the poor dough forming properties of the waxy flours, contrary to previous correlations made between IPP, UPP and dough strength. Gluten index determination showed a clear difference between waxy and normal flour; there was no gluten aggregation when the waxy samples were tested. The determination of gluten index done on a variety of water washed flour samples indicated that the water-extractable fraction may contain compounds that affect gluten aggregation. HPLC analysis coupled with arabinose/xylose ratio and viscosity determination of the water extractable portion of the flour indicated that water extractable arabinoxylans (WEAX) in waxy wheat flour were different in composition and conformation. Further research is needed to determine if they could be responsible for the lack of gluten aggregation in waxy flour.
Abdelkarim, Nazar B. H. "Numerical modelling of direct-injection gasoline fuel sprays". Thesis, Loughborough University, 2005. https://dspace.lboro.ac.uk/2134/34055.
Pełny tekst źródłaMüller, Alexandre Pastoris. "Sistema insulina/fator de crescimento semelhante à insulina 1 (insulina/IGF-1) em hipocampo de roedores : efeitos da interação com exercício físico, dieta hiperpalatável e envelhecimento". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/34655.
Pełny tekst źródłaInsulin and insulin like growth factor-1 (IGF-1) affect the brain function. Physical exercise is proposed as a neurotrophic factor, while aging is considered a key factor to neurodisease. In our work we analyze the effect of physical exercise, high palatable diet and aging in insulin/IGF-1 system in hippocampus of the mice. High palatable diet decreased the transport of IGF-1 in blood brain barrier (BBB) by increased in the serum levels of triglycerides. Aged mice/rats had decrease in insulin/IGF-1 system in brain. Aged mice try to compensate this impair in IGF-1 signaling by increase the transport of hIGF-1 in BBB and increased the levels of IGF-1 receptor in hippocampus, however the intracellular signaling were decreased in aged mice. Aged rats showed resistance to benefits effect of insulin in cognition. Physical exercise increases the insulin sensitivity in hippocampus by increase the translocation and activation of intracellular proteins. Moreover insulin showed an antioxidant effect in synaptossome of the rats. Our results pointing to environmental factors modulated the insulin/IGF-1 system and affect the brain function.
Joseph, Eloi. "L'appréhension du territoire penal par le Canada et la France". Master's thesis, Université Laval, 2018. http://hdl.handle.net/20.500.11794/34655.
Pełny tekst źródłaPlamondon, Mathieu. "La perception du rythme chez les personnes bègues". Master's thesis, Université Laval, 2019. http://hdl.handle.net/20.500.11794/34055.
Pełny tekst źródłaThis study assesses the effect of a speech disorder, namely stuttering, on the ability to maintain a steady rhythm. The performance of a group of adult stutterers (n = 21) is compared to that of a group of adult non-stutterers (n = 24) during explicit counting activities. There are three counting paces (every 800 ms, 1200 ms or 1600 ms) and three experimental conditions (count silently, count orally and count orally in the presence of an assistant). The results for temporal variability show lower performance (higher Weber ratio) when participants count silently and when they have to deal with very long intervals (1600 ms). There is no main effect of group, but the interaction between the experimental condition, the counting pace and the group is significant. Adult non-stutterers are better than adult stutterers in the silent and long time-interval condition (1600 ms). This finding could be interpreted as an indication of a greater limitation in memory for temporal information in people who stutter. Finally, the experiment shows that adult stutterers have a significantly higher situational anxiety score than adult non-stutterers. This result is consistent with the scientific literature indicating the high level of anxiety experienced by people who stutter.
Sirpatil, Brijesh. "Software Synthesis of SystemC Models". Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/34255.
Pełny tekst źródłaMaster of Science
Mishra, Sanjiv. "An Ex-Ante Economic Impact Assessment of Bt Eggplant in Bangladesh, the Philippines and India". Thesis, Virginia Tech, 2003. http://hdl.handle.net/10919/34955.
Pełny tekst źródłaMaster of Science
Tedesco, Patricia. "Interplay: Studies in Rowhouse Design". Thesis, Virginia Tech, 2001. http://hdl.handle.net/10919/34355.
Pełny tekst źródłaMaster of Architecture
Tinsley, Carl Terrie III. "Modeling of Multi-Pulse Transformer/Rectifier Units in Power Distribution Systems". Thesis, Virginia Tech, 2003. http://hdl.handle.net/10919/34655.
Pełny tekst źródłaMaster of Science
Stewart, Nathan Todd. "Treatment of Rainbow Trout (Oncorhynchus mykiss) Raceway Effluent Using Baffled Sedimentation and Artificial Substrates and Characterization of Nutrient Leaching Rates from Settled Rainbow Trout (Oncorhynchus mykiss) Sludge". Thesis, Virginia Tech, 2005. http://hdl.handle.net/10919/34555.
Pełny tekst źródłaTreatment of Rainbow Trout (Oncorhynchus mykiss) Raceway Effluent Using Baffled Sedimentation and Artificial Substrates
The treatment performance of a 6 m wide by 67 m long by 0.8 m deep, baffled sedimentation basin receiving rainbow trout (Oncorhynchus mykiss) raceway effluent was evaluated with and without the installation of artificial substrates (Aquamats®). Treatment efficiency was also determined using normal rearing condition effluent loading versus cleaning and harvesting events. Total suspended solids (TSS) removal for the total basin averaged 79% and 71% during normal rearing conditions, as compared to 92% and 79% during cleaning and harvesting operations, when the Aquamats® were installed versus removed, respectively. Total phosphorus (TP) removal by the total basin, with and without Aquamats®, was 20% and 23% during normal rearing conditions as compared to 55% and 65% under cleaning and harvesting conditions, respectively. Higher TP removal during cleaning operations was attributed to sedimentation of particulate fractions. Dissolved nutrient removal (ortho-phosphate (OP), total ammonia nitrogen (TAN), nitrate, nitrite, and total organic carbon (TOC)) was not consistent throughout the basin and did not improve when the Aquamats® were installed. A short contact time and periphyton grazing by isopods may have limited the capacity of the Aquamats®.
Calculated retention times with and without Aquamats® for the first half and total basin were 37% and 32% and 27% and 17% less than theoretical values, respectively based on a rhodamine WT dye study. Average surface overflow rates were adjusted accordingly and measured 19.1 m3/m2-day when the Aquamats® were installed, versus 14.8 m3/m2-day when the Aquamats® were removed for the overall basin. These rates are lower than previous recommendations for treating aquaculture effluents, but resulted in with high solids removal and consistently low TSS effluent (average < 2 mg/L) which may be necessary for strict discharge permits. Use of the overall basin minimized the occurrence of TSS measurements > 2 mg/L by 50%. For the first half of the sedimentation basin, the overflow rate averaged 44.1 m3/m2-day with Aquamats® versus 35.8 m3/m2-day without Aquamats®. The majority of effluent treatment occurred within the first half of the basin, which was responsible for 84% and 94% of total TSS removal, 42% and 100% and 61% and 80% of total TP removal during normal and cleaning/harvesting conditions, respectively.
Characterization of Nutrient Leaching Rates from Settled Rainbow Trout (Oncorhynchus mykiss) Sledge
The leaching of nutrients from settled rainbow trout (Oncorhynchus mykiss) sludge into overlying water was evaluated over a 7 day period. Nutrient leaching was assessed in a stagnant reaction tank and one agitated by aeration to simulate turbulent conditions in stocked production raceways. Leaching of total phosphorus (TP), ortho-phosphate (OP), total Kjeldahl nitrogen (TKN), total ammonia nitrogen (TAN), and total organic carbon (TOC) occurred rapidly during the first 24 h in both stagnant and agitated conditions. The highest 24 h leaching occurred in the agitated tank, and power regression equations accurately described the varying rates of increasing TP, OP, TAN and TKN. In the stagnant tank, linear increases of TP, OP, TKN and TAN concentrations occurred during the first 24 h. These linear increases continued from day 2-7, but at slower rates than occurred during the first 24 h. Average nutrient leaching rates (mg leached/g sludge-h);(dry weight basis) were calculated based on linear concentration increases. In the agitated tank, nutrient concentrations decreased after 60 h, as aerobic bacterial uptake and/or chemical precipitation was suspected. Therefore, average leaching rates could not be determined.
These findings reveal that daily cleanout of settling areas could eliminate the release of TP, OP, TAN, TKN, and TOC from settled solids by 66%, 65%, 39%, 76% and 51%, respectively, as compared to weekly cleanout schedules. Sustained leaching rates indicate nutrient release will likely continue beyond 7 days. This information suggests aggressive and continuous sludge management is most beneficial for maintaining high water quality and regulatory discharge compliance in fish production.
Master of Science
Williams, Ryan Williams. "Application of Spatial Analysis in the Incidence of the Gall Midge in Jamaican Hot Pepper Production". Thesis, Virginia Tech, 2001. http://hdl.handle.net/10919/34155.
Pełny tekst źródłaMaster of Science
Sherlock, Jay T. "Synthesis". Thesis, Virginia Tech, 2000. http://hdl.handle.net/10919/34055.
Pełny tekst źródłaMaster of Architecture