Gotowa bibliografia na temat „248/.2/092 b”
Utwórz poprawne odniesienie w stylach APA, MLA, Chicago, Harvard i wielu innych
Zobacz listy aktualnych artykułów, książek, rozpraw, streszczeń i innych źródeł naukowych na temat „248/.2/092 b”.
Przycisk „Dodaj do bibliografii” jest dostępny obok każdej pracy w bibliografii. Użyj go – a my automatycznie utworzymy odniesienie bibliograficzne do wybranej pracy w stylu cytowania, którego potrzebujesz: APA, MLA, Harvard, Chicago, Vancouver itp.
Możesz również pobrać pełny tekst publikacji naukowej w formacie „.pdf” i przeczytać adnotację do pracy online, jeśli odpowiednie parametry są dostępne w metadanych.
Artykuły w czasopismach na temat "248/.2/092 b"
1
Vallejo, Roger L., i Jane E. Polston. "248 COMPARISON OF MEDIUM, TISSUE TYPE AND GENOTYPE ON IN VITRO PLANT REGENERATION OF TOMATO". HortScience 29, nr 5 (maj 1994): 465b—465. http://dx.doi.org/10.21273/hortsci.29.5.465b.
Pełny tekst źródłaStreszczenie:
Cultured cotyledon and leaf pieces of five cultivars of Lycopersicon esculentum Mill. were tested in six culture media for their ability to produce shoots for transformation studies. The no. of tissue pieces with callus/total tissue pieces, quality of callus (size and vigor), no. of tissue pieces with shoots/total tissue pieces, and shoot quality (size and vigor) were measured. Cultivars tested were `Campbell 28', `Flora-Dade', `UC82b', and two breeding lines, Fla.7171 and Fla.7324. The six media used were Murashige and Skoog medium supplemented with six combinations of indole acetic acid (IAA) and cytokinins: A) 1 mg/l IAA + 1 mg/l kinetin, B) 0.5 mg/l IAA + 2 mg/l kinetin, C) 0.02 mg/l IAA + 1 mg/l zeatin, D) 0.2 mg/l IAA + 2 mg/l zestin, E) 1 mg/l IAA + 2.5 mg/l BAP (6-benzyl amino purine), and F) 0.2 mg/l IAA + 1 mg/l BAP. Standard procedures were followed for culturing 4 - 5 mm pieces of cotyledon and leaves. Callus and shoot regeneration were greater, less variable and faster, in cotyledon than in leaf pieces. Media C and F gave the highest rates of callus and shoot production, respectively, in cotyledon tissue. Medium E gave the highest rate for both callus and shoot production in leaf discs. The best rates of shoot production were achieved with cotyledon tissue from cultivar UC82b cultured on media C (85.3%) and F (77.2%).
2
Vargas, Carlos E., Thomas Daniels, Michael A. Golafshar, Sameer R. Keole, William Wong, Jean Claude Rwigema, Brian Davis i in. "A phase II trial of hypofractionated radiation therapy over five treatments for prostate cancer with high-risk features after radical prostatectomy: MC1754." Journal of Clinical Oncology 40, nr 6_suppl (20.02.2022): 248. http://dx.doi.org/10.1200/jco.2022.40.6_suppl.248.
Pełny tekst źródłaStreszczenie:
248 Background: Hypofractionated prostate cancer radiation has showed similar results in several prior phase III studies (PCG GU 003, PACE-B, and Hypo PC RT). However, prospective phase II-III clinical trial data testing 5 tx after prostatectomy is scarce. Methods: Between 2018 and 2019, 41 patients were treated after postprostatectomy for high risk features. 5 patients were treated adjuvantly, 36 for salvage including 8 with oligometastatic disease. Indications for adjuvant RT included a PSA < 0.2 and +margins, SVI, or EPE. Salvage RT was offered for PSA ≥0.2. Oligometastatic RT for patients with ≤5 RT targets. Staging included C11 PET for all cases. Total dose to the prostate bed was 30-32 Gy in 5tx QOD with IMRT, conebeam IGRT, and MRI registration. All salvage patients received ADT for 6 months and oligometastatic patients for 18 months. Dose to the metastatic sites was 30 in 5tx QOD. Of the 41 patients 8 also received SBRT to the sites of oligometastatic disease. We looked at clinical outcomes defining biochemical failure as a PSA > 0.2 after treatment, baseline adjusted CTC AE V5.0, baseline adjusted patient reported toxicities (PRO CTC AE), QOL (EPIC, PROMIS), and AUA was used for all cases. Results: Median follow up was 23 months (range 10-37). Pre-RT T stage was T2-T3b, with 47% being T3a-b; Pre RT Median PSA of 0.4 (range < 0.1-1.9); Median GS 8 (6-9); and (+) margins in 48.8%. Sites of oligometastatic disease radiated included the LN and bone. Treatment related AE were grade 0-1 in all cases, except for one patient with G2 GU incontinence. Overall QOL remained high during follow including Promis 10 overall, mental, and physical scores; urinary bother, irritative/obstructive, and AUA scores; bowel overall, bowel bother, and bowel function scores; and overall sexual, sexual function, and sexual bother scores remained at baseline levels during follow up. Only hormonal overall, hormonal function, and hormonal bother had lower scores at 3 months that recovered by 12 months in patients treated with ADT for 6 months and by 24 months in patients treated with ADT for 18 months. A total of 3 clinical failure have been seen; 2 patients with regional failures alone; and one with axial skeleton bony failures for 93% clinical control at median follow up of 23 months. All 3 patients with clinical failure were salvaged successfully with SBRT and all patients remain disease free at last follow up. A total 5 patients with raising PSAs alone have been seen. All patients have been re-staged with C11 PET. No failures in the prostate bed or previously radiated sites have been seen. Conclusions: Toxicity for RT over 5tx is lower than expected with only one case of grade 2 urinary incontinence. QOL scores remained high during follow up, minor changes in hormonal scores were seen during ADT, but recovered after. 30-32 Gy over 5 tx provided 100% control in radiated targets and metastatic sites. Clinical trial information: NCT03570827.
3
Zhila, Natalia O., Kristina Yu Sapozhnikova, Evgeniy G. Kiselev, Ivan V. Nemtsev, Anna V. Lukyanenko, Ekaterina I. Shishatskaya i Tatiana G. Volova. "Biosynthesis and Properties of a P(3HB-co-3HV-co-4HV) Produced by Cupriavidus necator B-10646". Polymers 14, nr 19 (9.10.2022): 4226. http://dx.doi.org/10.3390/polym14194226.
Pełny tekst źródłaStreszczenie:
Synthesis of P(3HB-co-3HV-co-4HV) copolymers by the wild-type strain Cupriavidus necator B-10646 on fructose or sodium butyrate as the main C-substrate with the addition of γ-valerolactone as a precursor of 3HV and 4HV monomers was studied. Bacterial cells were cultivated in the modes that enabled production of a series of copolymers with molar fractions of 3HV (from 7.3 to 23.4 mol.%) and 4HV (from 1.9 to 4.7 mol.%) with bacterial biomass concentration (8.2 ± 0.2 g/L) and PHA content (80 ± 2%). Using HPLC, DTA, DSC, X-Ray, SEM, and AFM, the physicochemical properties of copolymers and films prepared from them have been investigated as dependent on proportions of monomers. Copolymers are characterized by a reduced degree of crystallinity (Cx 38–49%) molecular weight characteristics Mn (45–87 kDa), and Mw (201–248 kDa) compared with P(3HB). The properties of the films surface of various composition including the porosity and surface roughness were studied. Most of the samples showed a decrease in the average pore area and an increase in their number with a total increase in 3HV and 4HV monomers. The results allow scaling up the productive synthesis of P(3HB-co-3HV-co-4HV) copolymers using Cupriavidus necator B-10646.
4
Punt, C. J., M. Koopman, J. Douma, J. Wals, A. H. Honkoop, F. L. Erdkamp, R. S. de Jong, C. J. Rodenburg, L. Mol i N. F. Antonini. "Sequential compared to combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (ACC): A Dutch Colorectal Cancer Group (DCCG) phase III study". Journal of Clinical Oncology 25, nr 18_suppl (20.06.2007): 4012. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.4012.
Pełny tekst źródłaStreszczenie:
4012 Background: Overall survival (OS) in phase III studies with 1st line combination therapy in ACC may be influenced by imbalances in salvage treatments. This is the first study that prospectively investigates the sequential vs the combined use of all available effective cytotoxic drugs. Methods: Previously untreated patients (pts), WHO PS 0–2 were randomized between 1st line capecitabine (Cap), 2nd line irinotecan (Iri), and 3rd line Cap + oxaliplatin (CapOx) (Arm A, sequential) vs 1st line CapIri and 2nd line CapOx (Arm B, combination). The dose of Cap was 1250 mg/m2 (mono) or 1,000 mg/m2 (combination) b.i.d. day 1–14, Iri 350 mg/m2 (mono) or 250 mg/m2 (combination), and Ox 130 mg/m2. All cycles were q 3 weeks with Iri/Ox given i.v. on day 1. Response was assessed q 3 cycles. Primary endpoint was OS. The study was designed to detect a 20% reduction in the hazard of death (HR=0.80) for an increase in median OS from 14 to 17.5 months (a=0.05, 2-tailed test). Results: 820 pts were randomized between Jan ‘03 and Dec ‘04 in 74 Dutch hospitals. Of 804 eligible pts, 796 received = 1 cycle. Median age was 63 (27–84) yrs, median WHO PS 0 (0–2), median follow-up 32 months. Pts (n) in arm A: 398 (1st line), 248 (2nd line), 141 (3rd line); arm B: 398 (1st line), 210 (2nd line). Median OS in arm A was 16.3 months (95%CI 14.3–18.2) and in arm B 17.7 months (95%CI 15.2–19.4), logrank p=0.2. Overall gr 3–4 toxicity over all lines did not differ significantly except for gr 3 hand-foot syndrome (HFS) (13% in A and 6% in B, p=0.0009). Death was probably related to treatment in 11 pts (neutropenic sepsis and/or diarrhea, 8 arm A, 3 arm B) and involved protocol violations in some. In 1st line significant differences in gr 3–4 toxicity in arm A vs arm B were diarrhea (10% vs 25%, p<0.0001), febrile neutropenia (1% vs 6%, p=0.0001) and HFS (12% vs 5%, p=0.0004). All-cause 60-day mortality was 3.0% (n=12) in arm A and 4.5% (n=18) in arm B. Updated results will be presented at the meeting, including data on QoL (EORTC QLQ C30). Conclusions: Combination therapy does not significantly improve OS compared with sequential therapy. Both treatment strategies are valid options for pts with ACC. No significant financial relationships to disclose.
5
Daussy-Turpain, Stéphanie. "Kristiane Lemé-Hébuterne , Les stalles de la cathédrale Notre-Dame d’Amiens , Paris, Picard, 2007, 28 cm, 248 p., 213 fig. en n. et b. et en coul., carte, plans, dessin. – ISBN : 978-2-7084-0792-3". Revue du Nord 379, nr 1 (1.01.2009): V. http://dx.doi.org/10.3917/rdn.379.0177e.
Pełny tekst źródła
6
Gudzenko, O. V., L. D. Varbanets, V. O. Ivanytsia i M. D. Shtenikov. "Representatives of Bacillus from Deep-Water Bottom Sediments of the Black Sea – Producers of Elastases, Fibrin(ogen)ases, and Collagenases". Mikrobiolohichnyi Zhurnal 86, nr 3 (22.06.2024): 51–57. http://dx.doi.org/10.15407/microbiolj86.03.051.
Pełny tekst źródłaStreszczenie:
Among microorganisms, bacteria and fungi are reported to be good sources of different types of enzymes, in particular proteases, which have a broad range of applications in industrial processes and products and are representative of most worldwide enzyme sales. The genus Bacillus is probably the most important bacterial source of proteases and is capable of producing high yields of neutral and alkaline proteolytic enzymes with remarkable properties, such as high stability toward extreme temperatures, pH, organic solvents, detergents, and oxidizing compounds. Earlier we have shown the ability of a number of strains of Bacillus sp. isolated from the bottom sediments of the Black Sea: 051, 054, 052 (depth 2080 m), and 247 (depth 1888 m) to display elastase activity (20.83 U/mL, 19.96 U/mL, 15.62 U/mL and 12.15 U/mL, respectively). Since the bacterial population of the deep-sea bottom sediments of the Black Sea has been little studied, the purpose of this work was to search for effective protease producers among the microbiota of the Black Sea water and sediments obtained from its various depths. Methods. The objects of the study were 20 cultures isolated from bottom sediments from 4 points at depths of 888–2080 m in the Black Sea. The cultures were grown under conditions of deep cultivation at 28 °С, with a mixing speed of the nutrient medium of 230 rpm for 2 days. Methods for determining proteolytic (elastolytic, fibrinolytic, fibrinogenolytic, and collagenase) activity in the culture liquid supernatant were used. Results. The research on the ability of the supernatants of the studied cultures to hydrolyze various proteolytic substrates has shown that promising for further investigations can be cultures 248 and 249, isolated under the same conditions (1499 m, 15–20 cm), but being representatives of different species, namely Bacillus subtilis and B. licheniformis, respectively. Supernatants of their culture liquids showed the greatest activity toward fibrin (20.5 U/mL and 19.0 U/mL) and fibrinogen (21.66 U/mL and 20 U/mL, respectively), while cultures of B. licheniformis 249 (1499 m, 15–20 cm), Priestia megaterium 55 (1537 m, 0–5 cm), and B. subtilis 1 (1499 m, 5–10 cm), which were isolated under different conditions, showed high activity toward elastin (33.3 U/mL, 31.2 U/mL and 29 U/mL, respectively). B. subtilis 1 is able to hydrolyze all investigated proteolytic substrates: elastin, fibrin, fibrinogen, and collagen, but the level of these activities was lower than in the above-mentioned strains. Conclusions. According to their catalytic properties, a number of representatives of bacteria Bacillus licheniformis 249, Priestia megaterium 55, and Bacillus subtilis 1 isolated from the deep-water bottom sediments of the Black sea may be promising for further research as producers of enzymes with elastolytic, fibrinolytic, and fibrinogenolytic activity.
7
Scott, Andrew C. "R. M. Davidson, L. L. Sloss & L. B. Clarke 1995. Coalbed Methane Extraction. IEACR/76. 67 pp. London: IEA Coal Research. Price £300 (paperback); substantial discounts to member countries and educational establishments. ISBN 92 0929 248 2." Geological Magazine 133, nr 06 (listopad 1996): 776. http://dx.doi.org/10.1017/s0016756800024687.
Pełny tekst źródła
8
Burford, Neil, Charles L. B. Macdonald, Trenton M. Parks, Gang Wu, Borzena Borecka, Witold Kwiatkowski i T. Stanley Cameron. "Preparation and structure of 2-chloro-1,3-dimethyldiaza-2-arsenane, 1,3-dimethyldiaza-2-arsenanium tetrachlorogallate, and butadiene cycloadducts of diazarsenium cations". Canadian Journal of Chemistry 74, nr 11 (1.11.1996): 2209–16. http://dx.doi.org/10.1139/v96-248.
Pełny tekst źródłaStreszczenie:
1,3-Dimethyldiaza-2-arsenanium tetrachlorogallate (crystal data: C5H12AsCl4GaN2, M = 386.61, orthorhombic, space group Pca21, a = 14.432(3) Å, b = 6.7580(14) Å, c = 13.905(3) Å, V = 1356.2(5) Å3) is synthesized by the routine chloride ion abstraction procedure from 2-chloro-1,3-dimethyldiaza-2-arsenane (crystal data: C5H12AsClN2, M = 210.54, monoclinic, space group P21/n, a = 7.206(1) Å, b = 9.650(1) Å, c = 13.021(2) Å, β = 99.61(2)°, V = 892.8(2) Å3). X-ray crystallographic studies of both compounds are described together with that for 2-chloro-1,3-dimethyldiaza-2-arsolidine (crystal data: C4H10AsClN2, M = 196.51, monoclinic, space group P21/n, a = 6.959(7) Å, b = 9.23(2) Å, c = 12.14(2) Å, β = 95.4(1)°, V = 777(4) Å3) providing useful structural comparisons. In contrast to the closely related arsolidinium salts, the diazarsenanium gallate exhibits a monomeric solid state structure. Rapid and quantitative cycloaddition reactions of the diazarsolidinium and diazarsenanium cations with 2,4-dimethylbutadiene give similar cycloadducts. The Diels–Alder type arsolidinium adduct is structurally characterized (crystal data: C10H20AsCl4GaN2, M = 454.73, orthorhombic, space group Pca21, a = 18.471(2) Å, b = 7.000(2) Å, c = 13.738(1) Å, V = 1776.2(8) Å3), and the related structure of the arsenanium cycloadduct is confirmed by 2D NMR. Key words: arsenium, cycloadditions, arsenanium, Diels–Alder, cyclochloroarsines.
9
Šindelář, Karel, Jiřina Metyšová i Miroslav Protiva. "Potential antidepressants: 2-(6,11-Dihydrodibenzo[b,e]thiepin-11-yl)-4,5-dihydroimidazoles". Collection of Czechoslovak Chemical Communications 54, nr 1 (1989): 229–34. http://dx.doi.org/10.1135/cccc19890229.
Pełny tekst źródłaStreszczenie:
Reactions of 2-substituted 11-chloro-6,11-dihydrodibenzo[b,e]thiepins with trimethylsilyl cyanide in dichloromethane in the presence of stannic chloride afforded nitriles IIb-IId in high yields. Heating of IIa-IId with 2-aminoethylammonium toluene-4-sulfonate to 200 °C gave the title compounds Ia-Id which were transformed to hydrogen maleates. Compound Ic (hydrogen maleate VÚFB-17 092) showed in several tests a clear thymoleptic (potential antidepressant) character.
10
Sasaki, Koji, Nina Shah, Qaiser Bashir, Chitra M. Hosing, Uday R. Popat, Yago Nieto, Simrit Parmar i in. "Outcome of Patients with Light Chain Multiple Myeloma Compared to IgG/IgA Myeloma after Autologous Stem Cell Transplant". Blood 126, nr 23 (3.12.2015): 3194. http://dx.doi.org/10.1182/blood.v126.23.3194.3194.
Pełny tekst źródłaStreszczenie:
Abstract Introduction: High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (auto-HCT) is the standard of care for younger patients with newly diagnosed multiple myeloma (MM). In approximately 15% of MM patients the monoclonal (M) spike consists of k or l light chains only as opposed to heavy + light chains. It remains unclear whether light chain (LC) MM has a different prognosis compared to other monoclonal protein subtypes after an auto-HCT. Methods: We retrospectively analyzed 1067 patients with MM who underwent auto-HCT between January 1, 2004 and January 1, 2011 at our institution. We evaluated the outcome of newly diagnosed patients with LCMM and compared it to patients with IgG or IgA MM, who underwent an auto-HCT after induction therapy. Primary endpoints were complete remission (CR), progression-free survival (PFS) and overall survival (OS) from the date of auto-HCT. Kaplan-Meier analysis with the log-rank test was performed for univariate comparison of survival. Cox proportional hazards regression method was used for univariate and multivariate analyses. Results: Of 1067 patients who underwent auto-SCT during the period, 223 underwent auto-SCT after relapse, and were excluded. From the remaining 844 who underwent auto-SCT in first remission, we excluded 102 patients (AL amyloidosis 60, POEMS and other plasma cell disorders 10, non-secretory MM 15, IgD 10, IgM 6 and IgE 1) from the analysis. The remaining 742 patients were divided as follows: IgA, 162 patients (22%); IgG, 444 (60%) and LC, 136 (18%). Baseline patient characteristics are described in Table 1. Patients with LCMM were younger and had a higher CR rate to induction. Median follow-up for the entire cohort after auto-HCT was 38 months (range, 0.2-87.0). Post auto-HCT, 28% with IgG/IgA MM and 38% with LCMM achieved a CR (p=0.015). Median PFS was 26.0 months and 27.7 months in IgG/IgA MM and LCMM groups, respectively (p= 0.742). Median OS was not reached and 71.1 months in IgG/IgA MM and LCMM groups, respectively (p= 0.18, Figure 1). Multivariate Cox regression analysis for PFS identified <PR after auto-SCT, non-diploid karyotype, and induction chemotherapy without thalidomide or bortezomib as adverse prognostic factors. Multivariate Cox regression analysis for OS identified presence of hypodiploidy or monosomy 13/del13, higher lactate dehydrogenase pre-transplant, lower hemoglobin pre-transplant, and <PR after auto-HCT as adverse prognostic factors. M protein subtype did not affect PFS (hazard ratio [HR], 1.040; 95% confidence interval [CI], 0.825-1.311; p=0.742) or OS (HR, 1.313; 95% CI, 0.874-1.971; p=0.190). Conclusions: Patients with LCMM have a higher CR rate after auto-HCT, but their PFS and OS were similar to patients with IgG/IgA MM. Table 1. Patient Characteristics Variables, No. (%)/median (range) IgG/IgA myelomaN= 606 Light chain myelomaN= 136 P Median age at transplant, (y) 59 (31-80) 56 (32-78) .004 Age >65 years 138 (23) 23 (17) .134 Male 357 (59) 74 (54) .337 Ethnicity .731 Caucasian 399 (66) 94 (69) African American 99 (16) 22 (16) Mixed 87 (14) 18 (13) Asian 16 (3) 2 (2) Cytogenetic abnormalities at diagnosis by conventional cytogenetics Diploid 180 (30) 36 (27) .159 Hyperdiploid 93 (15) 9 (7) .008 Hypodiploid 27 (5) 11 (8) .082 t(11;14) 4 (1) 3 (2) .092 Monosomy 13 / del 13 44 (7) 9 (7) .789 Other high-risk abnormalities 2 (0) 1 (1) .456 Induction chemotherapy Bortezomib or IMiD-based 507 (84) 123 (90) .046 Pre-transplant evaluation Bone marrow plasma cell, (%) 2 (0-71) 2 (0-50) .136 Bone marrow plasma cell >10% 90 (15) 18 (13) .735 Hemoglobin, (g/dL) 11.3 (4.4-16.0) 10.8 (6.8-15.3) .025 Lactate dehydrogenase, (IL/L) 526 (221-5062) 526 (239-2748) .522 Calcium, (mg/dL) 9.0 (7.6-10.4) 9.0 (7.5-11.0) .055 Creatinine, (mg/dL) 0.9 (0.4-12.5) 0.9 (0.5-9.8) .017 Beta-2 microglobulin (mg/dL) 2.4 (1.1-40.0) 2.8 (1.2-33.8) .001 Time from diagnosis to auto-HCT (month) 8.0 (1.9-174.4) 6.8 (2.4-44.6) .001 Pre-transplant disease status .004 ≥ CR 24 (4) 15 (11) VGPR/PR 545 (90) 109 (80) SD/PD 37 (6) 12 (9) Conditioning regimen .008 Melphalan alone 508 (84) 126 (93) Melphalan-based regimen 98 (16) 10 (7) Final response after transplant .080 ≥ CR 168 (28) 52 (38) VGPR/PR 353 (58) 70 (52) SD/PD 81 (13) 14 (10) Figure 1. a) Progression-free survival, b) Overall survival in patients with light chain myeloma compared to those with IgG/IgA myeloma Figure 1. a) Progression-free survival, b) Overall survival in patients with light chain myeloma compared to those with IgG/IgA myeloma Disclosures Shah: Celgene: Consultancy, Research Funding. Thomas:Novartis, Celgene, Acerta Pharmaceuticals, Idera Pharmaceuticals: Research Funding.
Rozprawy doktorskie na temat "248/.2/092 b"
1
Chen, Si-Ying, i 陳思穎. "A. Photodissociation of 2-bromopropionyl chloride at 248 nm B. The reaction of boron monoxide with acetylene". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/99658825169811404735.
Pełny tekst źródłaCzęści książek na temat "248/.2/092 b"
1
"91. Verbundenheit einer Religionsgemeinschaft i.S. von § 2 b DDR-PartG. OVG Berlin, Urteil vom 22.11.1996 (3 B 8/94)". W 1.1.–31.12.1996, 439–53. De Gruyter, 2000. http://dx.doi.org/10.1515/9783110893526-092.
Pełny tekst źródła
2
Saibene, Maria Grazia. "Miti e metamorfosi". W Tradurre: un viaggio nel tempo. Venice: Edizioni Ca' Foscari, 2018. http://dx.doi.org/10.30687/978-88-6969-248-2/010.
Pełny tekst źródłaStreszczenie:
The reworking of Ovid’sMetamorphosesby Albrecht von Halberstadt, dating back to the end of the twelfth century, survives only in few Fragments. In this essay, I will analyse Fragment B, which contains tales from Book XI of theMetamorphoses, in order to assess Albrecht’s rewriting techniques, and his simplification of both matter and style. Indeed, Albrecht employs the middle style, while his Latin source was written in a rhetorical and elevated style. Albrecht’s Fragments will be compared with the Ovidian source and with theEneitof Heinrich von Veldeke, highlighting the features shared by the two rewritings of classical texts, which were both commissioned by the Landgrave Hermann of Thuringia.
3
Taber, Douglass F. "Alkene and Alkyne Metathesis: Grandisol (Goess), 8-Epihalosilane (Kouklovsky/Vincent), (+)-Chinensiolide B (Hall)". W Organic Synthesis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199965724.003.0033.
Pełny tekst źródłaStreszczenie:
The cost of using Grubbs-type catalysts could be reduced dramatically if the turnover could be improved. Richard L. Pederson of Materia found (Organic Lett. 2010, 12, 984) that in MTBE at 50°C, the ring-closing metathesis of 1 proceeded to completion in 8 hours with just 500 ppm of H2 catalyst 2. Jianhui Wang of Tianjin University constructed (Angew. Chem. Int. Ed. 2010, 49, 4425) a modified H2 catalyst 5 tethered to a nitrobenzospiropyran. After the cyclization of 4 to 6 was run in CH2Cl2, the mixture was irradiated with visible light, converting 5 into its ionic form, which could be extracted with glycol/methanol, leaving little Ru residue in the cyclized product. In the dark, the catalyst reverted and could be extracted back into CH2Cl2 and reused. In a complementary approach, David W. Knight of Cardiff University found (Tetrahedron Lett. 2010, 51, 638) that the residual Ru after metathesis could be reduced to < 2 ppm simply by stirring the product with H2O2. Cyclopropenes such as 6 are readily available in enantiomerically pure form by the addition of diazoacetates to alkynes. Christophe Meyer and Janine Cossy of ESPCI ParisTech showed (Organic Lett. 2010, 12, 248) that with a Ti additive, G2 cyclized 7 to 8. Siegfried Blechert of the Technische Universität Berlin devised (Angew. Chem. Int. Ed. 2010, 49, 3972) the chiral Ru catalyst 11, which converted the prochiral 9 to 12 in high ee. Daesung Lee of the University of Illinois, Chicago, explored (J. Am. Chem. Soc. 2010, 132, 8840) the cyclization of the diyne 13 with 14 under G2 catalysis. Depending on the terminal substituent, the cyclization could be directed selectively to 15 or 16. Bran C. Goess of Furman University took advantage (J. Org. Chem. 2010, 75, 226) of alkyne ring-closing metathesis for the conversion of 17 to 18. Selective hydrogenation then delivered the boll weevil pheromone grandisol 19. Cyrille Kouklovsky and Guillaume Vincent of the Université de Paris Sud extended (J. Org. Chem. 2010, 75, 4333) ring-opening/ring-closing metathesis to the nitroso Diels-Alder adduct 20. Reduction led to 8-epihalosilane 22.
4
Li, Jie Jack, Chris Limberakis i Derek A. Pflum. "Carbon−Carbon Bond Formation". W Modern Organic Synthesis in the Laboratory. Oxford University Press, 2008. http://dx.doi.org/10.1093/oso/9780195187984.003.0011.
Pełny tekst źródłaStreszczenie:
Reviews: (a) Vicarion, J. L.; Badia, D.; Carillo, L.; Reyes, E.; Etxebarria, J. Curr. Org. Chem. 2005, 9, 219-235. (b) Mahrwald, R. Ed. In Modern Aldol Reactions; Wiley-VCH: Weinheim, 2004; Vol. 1., pp. 1-335 (c) Mahrwald, R. Ed. In Modern Aldol Reactions; Wiley-VCH: Weinheim, 2004; Vol. 2., pp. 1-345.(d) Machajewski, T. D.; Wong, C.-H. Angew. Chem. Int. Ed. 2000, 39, 1352-1375. (e) Carriera, E. M. In Modern Carbonyl Chemistry; Otera, J.; Wiley-VCH: Weinheim, 2000; Chapter 8: Aldol Reaction: Methodology and Stereochemistry, 227-248. (f) Paterson, I.; Cowden, C. J.; Wallace, D. J. In Modern Carbonyl Chemistry; Otera, J.; Wiley-VCH: Weinheim, 2000; Chapter 9: Stereoselective Aldol Reactions in the Synthesis of Polyketide Natural Products, pp. 249-298. (g) Franklin, A. S.; Paterson, I. Contemp. Org. Synth. 1994, 1 317-338. (h) Heathcock, C. H. In Asymmetric Synthesis; Morrison, J. D., Ed.; Academic Press: Orlando, Fl.; 1984; Vol. 3., Chapter 2: The Aldol Addition Reaction, pp. 111-212. (i) Mukaiyama, T. Org. React. 1982, 28, 203-331. Since the early 1980s, aldol condensations involving boron enolates have gain great importance in asymmetric synthesis, particularly the synthesis of natural products with adjacent stereogenic centers bearing hydroxyl and methyl groups. (Z)-Boron enolates tend to give a high diastereoslectivity preference for the syn-stereochemistry while (E)-boron enolates favor the anti-stereochemistry. Because the B-O and B-C bonds are shorter than other metals with oxygen and carbon, the six membered Zimmerman–Traxler transition state in the aldol condensation tends to be more compact which accentuates steric interactions, thus leading to higher diastereoselectivity. When this feature is coupled with a boron enolate bearing a chiral auxillary, high enantioselectivity is achieved. Boron enolates are generated from a ketone and boron triflate in the presence of an organic base such as triethylamine. Reviews: (a) Abiko, A. Acc. Chem. Res. 2004, 37, 387-395. (b) Cowden, C. J. Org. React. 1997, 51, 1-200.
Streszczenia konferencji na temat "248/.2/092 b"
1
Tolga Emre, N. C., Arthur L. Shaffer, George W. Wright, Holger Kohlhammer i Louis M. Staudt. "Abstract LB-248: IRF4 as a critical regulator and potential therapeutic target in ABC type diffuse large B-cell lymphoma". W Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-lb-248.
Pełny tekst źródła
2
Bertasi, Federico, Marco Bandiera, Alessandro Mancini, Ariana Pavesi, Andrea Bonfanti i Massimiliano Bestetti. "Lab-Scale Anodization of Prototype Brake Calipers". W EuroBrake 2021. FISITA, 2021. http://dx.doi.org/10.46720/3846714eb2021-stp-012.
Pełny tekst źródłaStreszczenie:
Anodization plays a pivotal role in improving the corrosion resistance of Aluminum-Silicon alloys (AlSix) used in the production of brake calipers.[1] However, the presence of eutectic Silicon particles within the Al matrix can reduce the oxide layer growing rate, leading to inhomogeneous and porous coatings. Following this, tailored current/potential anodization waveforms have been developed, in order to overcome the presence of Silicon, thus obtaining anodic layers with enhanced morphological and corrosion-resistance features.[2][3] In this scenario, a fervent lab-scale R&D activity has been carried out regarding the optimization of pulsed anodization in terms of current density and frequency of the used square wave, obtaining: 1) coated AlSix specimens (30cm2) showing a superior corrosion resistance; and 2) a set of refined anodization parameters to be used to treat AlSix –based materials.[4] Unfortunately, anodization of a prototype caliper, using the obtained optimized waveforms, is not straightforward and appears particularly more challenging with respect to the lab-scale treatment of small specimens. Indeed, the presence of: a) non-uniform Silicon distribution (machined vs. non-machined regions); and b) shielded areas and/or sharp edges; can strongly influence the oxide growth, leading to inhomogeneous coatings and a morphology-dependent corrosion resistance. As a further step toward the implementation of the optimized parameters in an anodization pilot plant, an electrochemical bath is designed, aiming at: 1) anodize a single brake caliper; and 2) scale up the anodization parameters from specimens to caliper treatment. The manuscript will discuss the so-obtained anodized caliper in terms of oxide layer: a) morphology; b) wettability; and c) corrosion resistance. The effect of optimized vs. non-optimized parameters will be discussed as well. Results allow to outline the path for an advanced anodization process, that will briefly lead to obtain AlSix brake calipers with an extended corrosion resistance. References: [1] Bandiera, M., Bonfanti, A., Mauri, A., Mancini, A., Bestetti, M., Bertasi, F., “Corrosion Phenomena in Braking Systems”, CORROSION/20, Manuscript no. C2020-14550, 2020. [2] Bandiera, M., Bonfanti, A., Bestetti, M., Bertasi, F., “Anodization: Recent Advancements on Corrosion Protection of Brake Calipers”, SAE Technical Paper, Manuscript no. 2020-01-1626, 2020. [3] Fratila-Apachitei, L. E., J. Duszczyk, and L. Katgerman. "AlSi (Cu) anodic oxide layers formed in H2SO4 at low temperature using different current waveforms", Surface and Coatings Technology, 165.3, pp. 232-240, 2003. [4] Bandiera, M., Mancini, A., Pavesi, A., Bonfanti, A., Bestetti, M., Bertasi, F., “Optimized Pulsed Anodization for Corrosion Protection of Aluminum Silicon Alloys”, CORROSION/21, Manuscript no. C2021-16431, 2021. (under review).
3
Schloss, J. H., D. B. Geohegan i J. G. Eden. "Bound—free absorption (photoassociation) in KrF". W International Laser Science Conference. Washington, D.C.: Optica Publishing Group, 1986. http://dx.doi.org/10.1364/ils.1986.wg7.
Pełny tekst źródłaStreszczenie:
Bound — free absorption of ultraviolet radiation by colliding pairs of rare gas-halogen atoms represents a potentially serious loss mechanism in the excimer lasers. This paper reports an investigation of the photoassociative production of KrF[Kr + F + ℏω)(248nm) → KrF(B)] in various Kr/F2 mixtures in order to obtain an absolute cross section forthe process. The studies involved the use of two KrF lasers. The first laser (I1 < 500 MW cm-2) was used to dissociate F2 and was fired ~1 μs prior to the firing of the second (l2 < 100 MWcm-2). The latter served to photoassociate the Kr-F collision pairs. Because of the efficient conversion of KrF(B) to Kr2F(42Γ), spontaneous emission from the Kr2F(42Γ) state was monitored to measure the photoassociation absorption strength. The intensity dependence of the photoassociation process was measured as a function of the intensity of each laser and the partial pressures of the reactants. The effective cross section obtained for the absorption is 3.2 × 10-18 cm2, a factor of 2 larger than the Kr2F absorption cross section at 248 nm. Also investigated were the effect of the time delay between the two KrF lasers, rates for quenching of Kr2F(42Γ) by both Kr and F2, and the wavelength dependence of the photodissociation effect. The impact of this process on KrF lasers is discussed.
4
Галенок, Р. Б., А. К. Овсянникова i О. Д. Рымар. "ОСОБЕННОСТИ ТЕЧЕНИЯ LADA ДИАБЕТА У ЛИЦ МОЛОДОГО ВОЗРАСТА". W X (XXIX) НАЦИОНАЛЬНЫЙ КОНГРЕСС ЭНДОКРИНОЛОГОВ с международным участием «Персонализированная медицина и практическое здравоохранение». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/cong23-26.05.23-283.
Pełny tekst źródłaStreszczenie:
ЦЕЛЬ: изучить особенности течения LADA диабета у пациентов молодого возраста (до 45 лет).
МАТЕРИАЛЫ И МЕТОДЫ: было обследовано 241 человек с началом сахарного диабета до 45 лет
в НИИТПМ-филиал ИЦиГ СО РАН. Проведен полный клинический осмотр, биохимический и гормональный
анализы (С-пептид, тиреотропный гормон) крови, определение гликированного гемоглобина, антитела
к b-клеткам, антитела к GAD (Glutamate decarboxylase), антитела к инсулину. Статистическая обработка данных проводилась с помощью программы IBM SPSS Statistics version 23. Среди всего количества пациентов
у 51 (21,1%) диагностирован LADA диабет (от англ. «Latent Autoimmune Diabetes in Adults»).
РЕЗУЛЬТАТЫ: группа пациентов с LADA включала 51 пациента, преобладали пациенты женского пола
(34 пациентов – 66,6%) по сравнению с мужским полом (17 пациента-33,4%) (p = 0,001), медиана возраста
на момент диагностики заболевания составляет 35,0 [32,0; 44,0] лет, медиана продолжительности течения заболевания – 10,0 [1,0;12,0] лет. По результатам исследований выяснено, что антитела к GAD диагностируется у 92,1% пациентов, поэтому нужно начинать диагностический поиск с этого вида антител,
антитела к b-клеткам были положительными у 13 пациентов (25,0%), к инсулину – у 8 (16,6%). Выявлено,
что из коморбидных заболеваний превалировали аутоиммунный тиреоидит (у 45 пациентов, 89,2%), что
показывает необходимость скрининга на данную патологию при этом типе сахарного диабета. Также
среди сопутствующих заболеваний определялась бронхиальная астма (у 13 пациентов, 25,0%). У 8 пациентов (16,6%) в анамнезе определены гипогликемические комы и потеря веса. Медиана гликированного
гемоглобина составляла 7,5 [7,1;9,2] %; уровень С-пептида был ниже референсных значений у 13 пациентов (25,0%) [0,2-0,8 ng/ml]. 38 пациентов (75,0%) используют антигипергликемические препараты: из них
75,0% - инсулин, 25,0% - пероральные сахароснижающие препараты, 13 пациентов (25,0%) обходятся без
лекарственной терапии.
ВЫВОДЫ:
1. При LADA среди исследуемых видов антител превалируют антитела к GAD, поэтому при скрининге
на LADA-диабет в первую очередь рекомендовано изучать эти антитела.
2. У трети пациентов с LADA-диабетом диагностируется аутоиммунный тиреоидит, поэтому необходимо
проводить скрининг на данную патологию у лиц с этим типом сахарного диабета.
5
Okita, J. R., M. M. Frojmovic, S. Kristopeit, T. Wong i T. J. Kunicki. "MONTREAL PLATELET SYNDROME: DECREASED ACTIVITY OF PLATELET CALPAINS ASSOCIATED WITH AGGREGATION ABNORMALITIES". W XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642822.
Pełny tekst źródłaStreszczenie:
The Montreal platelet syndrome (MPS) is an inherited disorder of platelet function characterized by a) severe thrombocytopenia, b) formation of "giant" platelets upon physical or biochemical stimulation, c) spontaneous aggregation (stir-induced microaggregate formation) and d) a lack of aggregation in response to thrombin. The Bernard-Soulier syndrome (BSS) is similar to MPS in that both syndromes are characterized by "giant" platelets and an abnormal aggregation response to thrombin. BSS patients have a deficiency of specific platelet glycoproteins (GPs). From our investigations we conclude MPS patients have apparently normal amounts of major platelet GPs. However, a defect in calpains (calcium-activated neutral proteinases) was detected in MPS platelets. The specific activity of calpains was decreased by 70% (p<0.001) in the cytosolic fraction of platelets from MPS patients as compared to that of platelets from normal control donors. The calpain activity of platelets from BSS patients was within the normal range.During the course of the biochemical studies, platelets from the MPS patients were shown to exhibit concurrent functional defects, i.e., stir-induced spontaneous aggregation and reduced to absent aggregation response to thrombin. It is concluded that MPS can be distinguished from BSS at the molecular level as follows: 1) MPS platelets contain normal amounts of GPs Ib, V and IX which are decreased or absent in BSS platelets; 2) The specific activity of calpains is reduced in MPS platelets but normal in BSS platelets. Supported by NIH (HL-33925, HL-32279), Amer. Heart Assoc. (85—GA—67, 83-186), Canadian Med. Res. Council (248-59) and Quebec Heart Fndn.