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Artykuły w czasopismach na temat „241D”

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Data publikacji: 6 września 2023

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1

Murali, R. V. N. S., i S. Chandrasekhar. "Stereocontrolled synthesis of piperidine alkaloids, (−)-241D and (−)-isosolenopsin". Tetrahedron Letters 53, nr 27 (lipiec 2012): 3467–70. http://dx.doi.org/10.1016/j.tetlet.2012.04.115.

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Ciblat, Stéphane, Pierre Calinaud, Jean-Louis Canet i Yves Troin. "A simple synthesis of (+)- and (−)-alkaloid 241D and C-4 epimers". Journal of the Chemical Society, Perkin Transactions 1, nr 3 (2000): 353–57. http://dx.doi.org/10.1039/a908265d.

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3

Saha, Nemai, i Shital K. Chattopadhyay. "Enantiodivergency and Enantioconvergency in the Synthesis of the Dendrobate Alkaloid 241D". Journal of Organic Chemistry 77, nr 24 (11.12.2012): 11056–63. http://dx.doi.org/10.1021/jo3019329.

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4

Sateesh Chandra Kumar, R., G. Venkateswar Reddy, G. Shankaraiah, K. Suresh Babu i J. Madhusudana Rao. "Stereoselective synthesis of dendrobate alkaloid (+)-241D and its C-4 epimer". Tetrahedron Letters 51, nr 7 (luty 2010): 1114–16. http://dx.doi.org/10.1016/j.tetlet.2009.12.111.

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5

Girard, Nicolas, i Jean-Pierre Hurvois. "Anodic cyanation of C-4 hydroxylated piperidines: total synthesis of (±)-alkaloid 241D". Tetrahedron Letters 48, nr 23 (czerwiec 2007): 4097–99. http://dx.doi.org/10.1016/j.tetlet.2007.04.010.

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6

Yang, Yang. "Building polyfunctional piperidines: a stereoselective strategy of a three-component Mannich reaction inspired by biosynthesis and applications in the synthesis of natural alkaloids (+)-241D; (−)-241D; isosolenopsin A and (−)-epimyrtine". RSC Advances 5, nr 24 (2015): 18894–908. http://dx.doi.org/10.1039/c4ra14418j.

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Ciblat, Stephane, Pierre Calinaud, Jean-Louis Canet i Yves Troin. "ChemInform Abstract: A Simple Synthesis of (+)- and (-)-Alkaloid 241D and C-4 Epimers." ChemInform 31, nr 22 (8.06.2010): no. http://dx.doi.org/10.1002/chin.200022193.

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8

Yang, Yang. "ChemInform Abstract: Building Polyfunctional Piperidines: A Stereoselective Strategy of a Three-Component Mannich Reaction Inspired by Biosynthesis and Applications in the Synthesis of Natural Alkaloids (+)-241D; (-)-241D; Isosolenopsin A and (-)-Epimyrti". ChemInform 46, nr 28 (25.06.2015): no. http://dx.doi.org/10.1002/chin.201528260.

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9

Gouault, Nicolas, Myriam Le Roch, Gisele de Campos Pinto i Michèle David. "Total synthesis of dendrobate alkaloid (+)-241D, isosolenopsin and isosolenopsin A: application of a gold-catalyzed cyclization". Organic & Biomolecular Chemistry 10, nr 29 (2012): 5541. http://dx.doi.org/10.1039/c2ob25685a.

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10

Monfray, Jérémy, Yvonne Gelas-Mialhe, Jean-Claude Gramain i Roland Remuson. "A new asymmetric synthesis of 2,6-cis-disubstituted 4-methylenepiperidines: total synthesis of (+)-alkaloid 241D and (+)-isosolenopsin A". Tetrahedron: Asymmetry 16, nr 5 (marzec 2005): 1025–34. http://dx.doi.org/10.1016/j.tetasy.2005.01.018.

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11

Chênevert, Robert, i Michael Dickman. "Enzymatic Route to Chiral, Nonracemiccis-2,6- andcis,cis-2,4,6-Substituted Piperidines. Synthesis of (+)-Dihydropinidine and Dendrobate Alkaloid (+)-241D". Journal of Organic Chemistry 61, nr 10 (styczeń 1996): 3332–41. http://dx.doi.org/10.1021/jo9519569.

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12

Harkiss, Alexander H., i Andrew Sutherland. "Access to 2,6-Disubstituted 4-Oxopiperidines Using a 6-Endo-trig Cyclization: Stereoselective Synthesis of Spruce Alkaloid and (+)-241D". Journal of Organic Chemistry 83, nr 1 (18.12.2017): 535–42. http://dx.doi.org/10.1021/acs.joc.7b02799.

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13

Das, Biswanath, i Kongara Damodar. "(N-tert-Butanesulfinyl)imines in Alkaloid Synthesis: Concise Formal Syntheses of the Dendrobate Alkaloid (+)-241D and Its C-4 Epimer¹". Synthesis 44, nr 01 (2.12.2011): 83–86. http://dx.doi.org/10.1055/s-0031-1289634.

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14

Khandare, Sopan P., Polimera Obula Reddy i Kavirayani R. Prasad. "Addition of Lithium Anion of (Acetylmethylene)triphenylphosphorane to Nonracemic Sulfinimines: Total Synthesis of (+)-241D and Formal Total Synthesis of (+)-Preussin". Organic Letters 22, nr 18 (27.08.2020): 7273–77. http://dx.doi.org/10.1021/acs.orglett.0c02608.

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15

Ma, Dawei, i Haiying Sun. "A Simple and Stereospecfic Route to 2,6-Disubstituted 4-Hydroxypiperidines. Synthesis of Dendrobate Alkaloid (+)-241D and Formal Synthesis of (−)-Indolizidine 167B". Organic Letters 2, nr 16 (sierpień 2000): 2503–5. http://dx.doi.org/10.1021/ol006176n.

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16

Edwards, Michael W., H. Martin Garraffo i John W. Daly. "Facile Synthesis of 4-Piperidones by Condensation of an α,β-Unsaturated Ketone, an Aldehyde and Ammonia: Synthesis of theDendrobatidFrog Alkaloid 241D". Synthesis 1994, nr 11 (1994): 1167–70. http://dx.doi.org/10.1055/s-1994-25665.

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17

Davis, Franklin A., Bin Chao i Ashwin Rao. "Intramolecular Mannich Reaction in the Asymmetric Synthesis of Polysubstituted Piperidines: Concise Synthesis of the Dendrobate Alkaloid (+)-241D and Its C-4 Epimer". Organic Letters 3, nr 20 (październik 2001): 3169–71. http://dx.doi.org/10.1021/ol0164839.

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18

Abrunhosa-Thomas, Isabelle, Aurélie Plas, Alexandre Vogrig, Nishanth Kandepedu, Pierre Chalard i Yves Troin. "Access to 2,6-Disubstituted Piperidines: Control of the Diastereoselectivity, Scope, and Limitations. Applications to the Stereoselective Synthesis of (−)-Solenopsine A and Alkaloid (+)-241D". Journal of Organic Chemistry 78, nr 6 (28.02.2013): 2511–26. http://dx.doi.org/10.1021/jo302712f.

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19

CHENEVERT, R., i M. DICKMAN. "ChemInform Abstract: Enzymatic Route to Chiral, Nonracemic cis-2,6- and cis,cis-2,4,6- Substituted Piperidines. Synthesis of (+)-Dihydropinidine (VI) and Dendrobate Alkaloid (+)-241D (VII)." ChemInform 27, nr 37 (5.08.2010): no. http://dx.doi.org/10.1002/chin.199637193.

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20

Abrunhosa-Thomas, Isabelle, Aurelie Plas, Alexandre Vogrig, Nishanth Kandepedu, Pierre Chalard i Yves Troin. "ChemInform Abstract: Access to 2,6-Disubstituted Piperidines: Control of the Diastereoselectivity, Scope, and Limitations. Applications to the Stereoselective Synthesis of (-)-Solenopsine A and Alkaloid (+)-241D." ChemInform 44, nr 30 (4.07.2013): no. http://dx.doi.org/10.1002/chin.201330164.

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21

Ma, Dawei, i Haiying Sun. "ChemInform Abstract: A Simple and Stereospecific Route to 2,6-Disubstituted 4-Hydroxypiperidines. Synthesis of Dendrobate Alkaloid (+)-241D (XII) and Formal Synthesis of (-)-Indolizidine 167B (XVII)." ChemInform 31, nr 45 (7.11.2000): no. http://dx.doi.org/10.1002/chin.200045155.

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22

Kazi, Aslamuzzaman, Adam Carie, Michelle A. Blaskovich, Cynthia Bucher, Van Thai, Stacy Moulder, Hairuo Peng i in. "Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27Kip1 Phosphorylation on Thr187 and Accumulates p27Kip1 in the Nucleus: Implications for Breast Cancer Therapy". Molecular and Cellular Biology 29, nr 8 (9.02.2009): 2254–63. http://dx.doi.org/10.1128/mcb.01029-08.

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ABSTRACT We describe the design of a potent and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI), GGTI-2418, and its methyl ester GGTI-2417, which increases the levels of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 and induces breast tumor regression in vivo. Experiments with p27Kip1 small interfering RNA in breast cancer cells and p27Kip1 null murine embryonic fibroblasts demonstrate that the ability of GGTI-2417 to induce cell death requires p27Kip1. GGTI-2417 inhibits the Cdk2-mediated phosphorylation of p27Kip1 at Thr187 and accumulates p27Kip1 in the nucleus. In nude mouse xenografts, GGTI-2418 suppresses the growth of human breast tumors. Furthermore, in ErbB2 transgenic mice, GGTI-2418 increases p27Kip1 and induces significant regression of breast tumors. We conclude that GGTIs' antitumor activity is, at least in part, due to inhibiting Cdk2-dependent p27Kip1 phosphorylation at Thr187 and accumulating nuclear p27Kip1. Thus, GGTI treatment might improve the poor prognosis of breast cancer patients with low nuclear p27Kip1 levels.

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23

Vu, Van Ha, Fadila Louafi, Nicolas Girard, Ronan Marion, Thierry Roisnel, Vincent Dorcet i Jean-Pierre Hurvois. "Electrochemical Access to 8-(1-Phenyl-ethyl)-1,4-dioxa-8-aza-spiro[4.5]decane-7-carbonitrile. Application to the Asymmetric Syntheses of (+)-Myrtine and Alkaloid (+)-241D". Journal of Organic Chemistry 79, nr 8 (3.04.2014): 3358–73. http://dx.doi.org/10.1021/jo500104c.

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24

Davis, Franklin A., Bin Chao i Ashwin Rao. "ChemInform Abstract: Intramolecular Mannich Reaction in the Asymmetric Synthesis of Polysubstituted Piperidines: Concise Synthesis of the Dendrobate Alkaloid (+)-241D (I) and Its C-4 Epimer (II)." ChemInform 33, nr 5 (23.05.2010): no. http://dx.doi.org/10.1002/chin.200205207.

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25

EDWARDS, M. W., H. M. GARRAFFO i J. W. DALY. "ChemInform Abstract: Facile Synthesis of 4-Piperidones by Condensation of an α,β- Unsaturated Ketone, an Aldehyde and Ammonia: Synthesis of the Dendrobatid Frog Alkaloid 241D (XII)." ChemInform 26, nr 18 (18.08.2010): no. http://dx.doi.org/10.1002/chin.199518264.

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Vu, Van Ha, Fadila Louafi, Nicolas Girard, Ronan Marion, Thierry Roisnel, Vincent Dorcet i Jean-Pierre Hurvois. "ChemInform Abstract: Electrochemical Access to 8-(1-Phenyl-ethyl)-1,4-dioxa-8-aza-spiro[4.5]decane-7-carbonitrile. Application to the Asymmetric Syntheses of (+)-Myrtine and Alkaloid (+)-241D." ChemInform 45, nr 41 (25.09.2014): no. http://dx.doi.org/10.1002/chin.201441210.

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27

Hu, Mingxing, Chao Yang, Yi Luo, Fan Chen, Fangfang Yang, Shuping Yang, Hao Chen, Zhiqiang Cheng, Kun Li i Yongmei Xie. "Correction: A hypoxia-specific and mitochondria-targeted anticancer theranostic agent with high selectivity for cancer cells". Journal of Materials Chemistry B 6, nr 26 (2018): 4385. http://dx.doi.org/10.1039/c8tb90081g.

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28

Langyan, Sapna, Zahoor A. Dar, D. P. Chaudhary, J. C. Shekhar, Susila Herlambang, Hesham El Enshasy, R. Z. Sayyed i S. Rakshit. "Analysis of Nutritional Quality Attributes and Their Inter-Relationship in Maize Inbred Lines for Sustainable Livelihood". Sustainability 13, nr 11 (29.05.2021): 6137. http://dx.doi.org/10.3390/su13116137.

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The present investigation was planned to understand the variability and inter-relationship among various nutritional quality attributes of maize kernels to identify potential donors of the respective traits for future hybridization programs. Sixty-three maize inbred lines were processed for the estimation of protein, starch, fat, sugar, 100-kernel weight, specific gravity, and moisture level of the grain. The results reveal that a wide variability among protein, starch, 100-kernel weight, specific gravity, and fat was seen, with special emphasis on the protein concentration that varied from 8.83 to 15.54%, starch (67.43–75.31%), and 100-kernel weight (9.14–36.11 gm). Factor analysis revealed that the protein concentration, starch, and 100-kernel weight, the three major components, comprise 68.58% of the kernel variability. Protein exhibited a significant negative correlation with starch and 100-kernel weight, indicating that an increase in the protein concentration will down-regulate the starch and 100-kernel weight. The inbred lines are proposed as donors for the development of high cultivars for their respective traits, viz., high protein (DMR WNC NY 403 and DMR WNC NY 404), high starch concentration (DMR WNC NY 2163, DMR WNC NY 2219, DMR WNC NY 2234, DMR WNC NY 2408, DMR WNC NY 2437, and DMR WNC NY 2466), high 100-kernel wt. (DMR WNC NY 2113, DMR WNC NY 2213, DMR WNC NY 2233, DMR WNC NY 2234, DMR WNC NY 2414, DMR WNC NY 2435, DMR WNC NY 2465, and DMR WNC NY 2474), sugar (DMR WNC NY 2417), and specific gravity (DMR WNC NY 2418). Genetic distance analysis revealed that DMR WNC NY 397 and DMR WNC NY 404 are the farthest apart inbred lines, having major differences in their protein, fat, starch, and sugar contents, followed by DMR WNC NY 2436 and DMR WNC NY 2394, DMR WNC NY 2212 and DMR WNC NY 2430, DMR WNC NY 396 and DMR WNC NY 2415, DMR WNC NY 404 and DMR WNC NY 2144, and DMR WNC NY403 and DMR WNC NY 2115. Moreover, this study proposes that these possible combinations of lines (in a breeding program) would result in genetic variability with simultaneous high values for the respective characteristics.

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Weng, Leiyun, Yuichi Hirata, Masaaki Arai, Michinori Kohara, Takaji Wakita, Koichi Watashi, Kunitada Shimotohno, Ying He, Jin Zhong i Tetsuya Toyoda. "Sphingomyelin Activates Hepatitis C Virus RNA Polymerase in a Genotype-Specific Manner". Journal of Virology 84, nr 22 (15.09.2010): 11761–70. http://dx.doi.org/10.1128/jvi.00638-10.

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ABSTRACT Hepatitis C virus (HCV) replication and infection depend on the lipid components of the cell, and replication is inhibited by inhibitors of sphingomyelin biosynthesis. We found that sphingomyelin bound to and activated genotype 1b RNA-dependent RNA polymerase (RdRp) by enhancing its template binding activity. Sphingomyelin also bound to 1a and JFH1 (genotype 2a) RdRps but did not activate them. Sphingomyelin did not bind to or activate J6CF (2a) RdRp. The sphingomyelin binding domain (SBD) of HCV RdRp was mapped to the helix-turn-helix structure (residues 231 to 260), which was essential for sphingomyelin binding and activation. Helix structures (residues 231 to 241 and 247 to 260) are important for RdRp activation, and 238S and 248E are important for maintaining the helix structures for template binding and RdRp activation by sphingomyelin. 241Q in helix 1 and the negatively charged 244D at the apex of the turn are important for sphingomyelin binding. Both amino acids are on the surface of the RdRp molecule. The polarity of the phosphocholine of sphingomyelin is important for HCV RdRp activation. However, phosphocholine did not activate RdRp. Twenty sphingomyelin molecules activated one RdRp molecule. The biochemical effect of sphingomyelin on HCV RdRp activity was virologically confirmed by the HCV replicon system. We also found that the SBD was the lipid raft membrane localization domain of HCV NS5B because JFH1 (2a) replicon cells harboring NS5B with the mutation A242C/S244D moved to the lipid raft while the wild type did not localize there. This agreed with the myriocin sensitivity of the mutant replicon. This sphingomyelin interaction is a target for HCV infection because most HCV RdRps have 241Q.

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Sriratanasak, Nicharat, Worawat Wattanathana i Pithi Chanvorachote. "6,6′-((Methylazanedyl)bis(methylene))bis(2,4-dimethylphenol) Induces Autophagic Associated Cell Death through mTOR-Mediated Autophagy in Lung Cancer". Molecules 27, nr 19 (22.09.2022): 6230. http://dx.doi.org/10.3390/molecules27196230.

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Autophagy is the multistep mechanism for the elimination of damaged organelles and misfolded proteins. This mechanism is preceded and may induce other program cell deaths such as apoptosis. This study unraveled the potential pharmacological effect of 24MD in inducing the autophagy of lung cancer cells. Results showed that 24MD was concomitant with autophagy induction, indicating by autophagosome staining and the induction of ATG5, ATG7 and ubiquitinated protein, p62 expression after 12-h treatment. LC3-I was strongly conversed to LC3-II, and p62 was downregulated after 24-h treatment. The apoptosis-inducing activity was found after 48-h treatment as indicated by annexin V-FITC/propidium iodide staining and the activation of caspase-3. From a mechanistic perspective, 24-h treatment of 24MD at 60 μM substantially downregulated p-mTOR. Meanwhile, p-PI3K and p-Akt were also suppressed by 24MD at concentrations of 80 and 100 μM, respectively. We further confirmed m-TOR-mediated autophagic activity by comparing the effect of 24MD with rapamycin, a potent standard mTOR1 inhibitor through Western blot and immunofluorescence assays. Although 24MD could not suppress p-mTOR as much as rapamycin, the combination of rapamycin and 24MD could increase the mTOR suppressive activity and LC3 activation. Changing the substituent groups (R groups) from dimethylphenol to ethylphenol in EMD or changing methylazanedyl to cyclohexylazanedyl in 24CD could only induce apoptosis activity but not autophagic inducing activity. We identified 24MD as a novel compound targeting autophagic cell death by affecting mTOR-mediated autophagy.

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31

Reddy, Arava Amaranadha, Polimera Obula Reddy i Kavirayani R. Prasad. "Synthesis of β-Amino-Substituted Enones by Addition of Substituted Methyl Enones to Sulfinimines: Application to the Total Synthesis of Alkaloids (+)-Lasubine II and (+)-241D and the Formal Total Synthesis of (−)-Lasubine I". Journal of Organic Chemistry 81, nr 22 (20.10.2016): 11363–71. http://dx.doi.org/10.1021/acs.joc.6b01541.

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Gao, X., S. Lester, B. Matheson, B. Boettcher i J. McCluskey. "Three newly identified A*24 alleles: A*2406, A*2413 and A*2414". Tissue Antigens 50, nr 2 (sierpień 1997): 192–96. http://dx.doi.org/10.1111/j.1399-0039.1997.tb02858.x.

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Comstock, Laurie E. "Small RNAs Repress Expression of Polysaccharide Utilization Loci of Gut Bacteroides Species". Journal of Bacteriology 198, nr 18 (11.07.2016): 2396–98. http://dx.doi.org/10.1128/jb.00514-16.

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Bacteroidesspecies can metabolize numerous plant polysaccharides and host glycans present in the mammalian gut. The regulatory systems governing the induction of particular polysaccharide utilization loci when the cognate glycan is present are known, but how expression is repressed when a higher-priority glycan is present is largely unknown. In this issue of theJournal of Bacteriology, Cao et al. (J. Bacteriol. 198:2410–2418, 2016,http://dx.doi.org/10.1128/JB.00381-16) reveal a conserved mechanism inBacteroideswhereby antisense small RNAs (sRNA) repress expression of genes involved in utilization of host glycans.

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A. Nikulin, Andrey. "The Object of the Right Concept for State Ownership of Land". HELIX 8, nr 01 (1.01.2018): 2411–14. http://dx.doi.org/10.29042/2018-2411-2414.

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Yu. Tumanov, Dmitriy. "The Conscience of the Jury as a Basis for Delivering a Fair Verdict in Accordance with the Judicial Reform of 1864 in Russia (Historico-Juridical Research)". HELIX 8, nr 01 (1.01.2018): 2415–19. http://dx.doi.org/10.29042/2018-2415-2419.

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&NA;. "2411". Medicine & Science in Sports & Exercise 37, Supplement (maj 2005): S461. http://dx.doi.org/10.1249/00005768-200505001-02411.

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&NA;. "2417". Medicine & Science in Sports & Exercise 37, Supplement (maj 2005): S463. http://dx.doi.org/10.1249/00005768-200505001-02417.

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&NA;. "2411". Medicine & Science in Sports & Exercise 37, Supplement (maj 2005): S461. http://dx.doi.org/10.1097/00005768-200505001-02411.

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&NA;. "2417". Medicine & Science in Sports & Exercise 37, Supplement (maj 2005): S463. http://dx.doi.org/10.1097/00005768-200505001-02417.

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Hirata, M., S. Araki, T. Hirai, H. Ohishi i T. Jibiki. "2410". Ultrasound in Medicine & Biology 32, nr 5 (maj 2006): P174—P175. http://dx.doi.org/10.1016/j.ultrasmedbio.2006.02.706.

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Marcelino, A., M. Pinho, P. Viana, O. Saito, A. de Oliveira, M. Chammas i G. Cerri. "2411". Ultrasound in Medicine & Biology 32, nr 5 (maj 2006): P175. http://dx.doi.org/10.1016/j.ultrasmedbio.2006.02.707.

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Choi, J. Y., J. Y. Lee, J. M. Lee, S. H. Kim, M. W. Lee, J. K. Han i B. I. Choi. "2413". Ultrasound in Medicine & Biology 32, nr 5 (maj 2006): P175. http://dx.doi.org/10.1016/j.ultrasmedbio.2006.02.708.

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Li, R., Y. Guo, X. Hua, J. Ding, A. Guo i X. Zhang. "2414". Ultrasound in Medicine & Biology 32, nr 5 (maj 2006): P175—P176. http://dx.doi.org/10.1016/j.ultrasmedbio.2006.02.710.

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Kim, S. Y., K. W. Kim, S. H. Park, S. S. Lee, Y. M. Shin, P. N. Kim, M. G. Lee i S. G. Lee. "2415". Ultrasound in Medicine & Biology 32, nr 5 (maj 2006): P176. http://dx.doi.org/10.1016/j.ultrasmedbio.2006.02.711.

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Lee, S. S., K. W. Kim, S. H. Park, J. H. Byun, Y. M. Shin, H. J. Won, A. Y. Kim, P. N. Kim, M. G. Lee i H. K. Ha. "2416". Ultrasound in Medicine & Biology 32, nr 5 (maj 2006): P176. http://dx.doi.org/10.1016/j.ultrasmedbio.2006.02.712.

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Lee, S. S., K. W. Kim, S. H. Park, Y. M. Shin, J. H. Byun, H. J. Won, A. Y. Kim, P. N. Kim, M. G. Lee i H. K. Ha. "2417". Ultrasound in Medicine & Biology 32, nr 5 (maj 2006): P176. http://dx.doi.org/10.1016/j.ultrasmedbio.2006.02.713.

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Whitt-Glover, Melicia C. "2419". Medicine & Science in Sports & Exercise 48 (maj 2016): 663. http://dx.doi.org/10.1249/01.mss.0000486988.72002.54.

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