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Pakaya, Fidyawansyah, Lia Amalia i Yasir Mokodompis. "Karakteristik Demogradi Dan Perilaku Penderita Hipertensi Peserta Prolanis Di Wilayah Kerja Puskesmas Kabila". Madu : Jurnal Kesehatan 10, nr 2 (28.12.2021): 34. http://dx.doi.org/10.31314/mjk.10.2.34-45.2021.
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AbstrakHipertensi menyebabkan timbulnya suatu penyakit yang dibawa akibat tekanan darah yang tinggi. Hipertensi di Provinsi Gorontalo menempati urutan ke-6 dengan prevalensi 8,4%. Tujuan dari penelitian ini yaitu untuk mengetahui Karakteristik Demografi dan Perilaku Penderita Hipertensi Peserta Prolanis di Wilayah Kerja Puskesmas Kabila. Jenis penelitian survei deskriptif dengan populasi sebanyak 609 responden dan sampel sebanyak 203 responden menggunakan analisis data univariat. Hasil menunjukan dari 203 responden, terdapat 59 responden (29,9%) yang ber-umur 51-60 tahun merupakan responden terbanyak penderita hipertensi peserta prolanis, 126 responden (62,1%) yang berjenis kelamin perempuan, 113 responden (55,7%) yang memiliki riwayat keluarga yang diturunkan oleh ibu, 141 responden (69,5%) yang obesitas, 51 responden (25,1%) yang pernah merokok, 46 responden (22,7%) yang mengonsumsi alkohol dan 137 responden (67,5%) yang mengonsumsi garam. Pola hidup sehat juga perlu diterapkan seperti mengurangi makanan tinggi garam, berhenti merokok dan berhenti mengonsumsi alkohol. AbstractHypertension causes a disease caused by high blood pressure. Hypertension in Gorontalo Province ranks 6th with a prevalence of 8.4%. The purpose of this study was to determine the Demographic and Behavioral Characteristics of Hypertension Patients in the Work Area of the Kabila Health Center. This type of research is a descriptive survey with a population of 609 respondents and a sample of 203 respondents using univariate data analysis. The results show that from 203 respondents, there are 59 respondents (29.9%) aged 51-60 years who are respondents with hypertension who are prolanis participants, 126 respondents (62.1%) are female, 113 respondents (55.7%) ) who had a family history passed down by their mother, 141 respondents (69.5%) were obese, 51 respondents (25.1%) had ever smoked, 46 respondents (22.7%) consumed alcohol and 137 respondents (67 , 5%) who consume salt. A healthy lifestyle also needs to be applied, such as reducing high-salt foods, quitting smoking and quitting alcohol.
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Larkin, Fionnuala, Elizabeth Meins, Luna C. M. Centifanti, Charles Fernyhough i Susan R. Leekam. "How does restricted and repetitive behavior relate to language and cognition in typical development?" Development and Psychopathology 29, nr 3 (15.07.2016): 863–74. http://dx.doi.org/10.1017/s0954579416000535.
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AbstractRelations between restricted and repetitive behavior at age 26 months and children's concurrent (N = 203) and later (n = 161) social cognition and language development were investigated. Restricted and repetitive behavior was assessed using two scales: sensory and motor repetitive behaviors and rigidity/routines/restricted interests. Language was assessed at ages 26 and 51 months; social cognition was assessed at ages 26 (symbolic play) and 51 and 61 months (theory of mind). Sensory and motor repetitive behavior was negatively related to children's (a) language performance at 26 and 51 months, (b) instructed symbolic play at 26 months, and (c) theory of mind performance at 51 and 61 months. Path analyses showed that children's sensory and motor repetitive behavior at age 26 months was related to lower receptive verbal ability and theory of mind at 51 months, which led to lower theory of mind at 61 months. Rigidity/routines/restricted interests at 26 months were unrelated to concurrent and later social cognition and language. These results are discussed in terms of the pathways via which sensory and motor repetitive behavior might impact negatively on development.
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Tang, Vincent CY, John Gillooly, Elaine WY Lee i Clive R. Charig. "Ureteric Stent Card Register – A 5-Year Retrospective Analysis". Annals of The Royal College of Surgeons of England 90, nr 2 (marzec 2008): 156–59. http://dx.doi.org/10.1308/003588408x242123.
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INTRODUCTION Ureteric stenting is a common urological procedure. Forgotten stents have a well-documented morbidity and mortality. Therefore, we asked the question, is a stent register an important factor in reducing the number of lost or overdue stents? PATIENTS AND METHODS We conducted a retrospective review of 203 patients who had ureteric stents inserted in the operating theatre, for the 5-year period 1 December 1998 to 1 December 2003. We analysed all stent cards, patient notes and theatre logs; where no record of stent removal was found, we contacted the patient, their GP or their local hospital. RESULTS A total of 191 patients were identified from the stent card register. An additional 12 patients were found from the theatre logs, but with no record in the stent card register. Of the 203 patients, 8 had bilateral stents. The most common indication for stenting was stone disease. Of the 203 patients, 11 had overdue stents and 51 had no record of the stents ever being removed. The 51 presumed ‘forgotten’ stents were traced, and it was found that 42 patients had had their stents removed by other hospitals, and 9 patients died with stents in situ, but before they were due for removal. CONCLUSIONS Our current stent card tracking system is ineffective, because it was infrequently reviewed. However, despite overdue and ‘forgotten’ stents which were removed by other hospitals, no patients came to any real harm and we had no lost stents. Our stent register system did not appear to play any role in terms of preventing stent loss, and it seems likely that there are other more effective safeguards in place to prevent this from happening. However, if a stent register was required at all, a computerised system would be preferable. Alternatively, patients could share some of the responsibility of stent tracking with their clinicians.
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Pegoraro, Cristiane Martinez Ruiz, Renata Mano Scatamburlo Bifaroni, Edson Asssunção Mareco, Thaise Ramires Tonizza i Ludmila Ichioka Silgueiro. "CARACTERIZAÇÃO DA PRÁTICA DE AUTOMEDICAÇÃO COM ANALGÉSICOS PARA O TRATAMENTO DA DOR". Colloquium Vitae 11, nr 3 (20.12.2019): 85–91. http://dx.doi.org/10.5747/cv.2019.v11.n3.v274.
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Self-medication is very common among people of all ages, usually through nominations from third parties, self-knowledge or easy access in pharmacies. The objective of the study was to evaluate and verify the prevalence of self-medication for the treatment of pain in patients seen in campaigns conducted by Universidade do Oeste Paulista. A questionnaire was applied involving socio-demographic aspects, drug use, the practice of self-medication and types of pain. The sample consisted of 248 participants, where 203 admitted the use of non-steroidal anti-inflammatory drugs(AINEs). Of these 203, 166 (81.7%) reported self-medication, being dipyrone (48.5%) and paracetamol (21.1%), themost frequently mentioned AINEs. The headache was more prevalent in women 99 (26.8%) and men 51 (13.8%), being womenconsidered the ones who most read the package leaflet 70 (34.5%) and know the effects adverse effects of the same 49 (24.2%). It can be concluded that the practice of self-medication is very frequent in the studied population.
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Giarin, Manuela M., Luisa Giaccone, Roberto Sorasio, Christian Sfiligoi, Barbara Amoroso, Federica Cavallo, Alessia Cipriani, Antonio Palumbo i Mario Boccadoro. "Serum Free Light Chain Ratio, Total κ/λ Ratio, and Immunofixation Results Are Not Prognostic Factors after Stem Cell Transplantation for Newly Diagnosed Multiple Myeloma". Clinical Chemistry 55, nr 8 (1.08.2009): 1510–16. http://dx.doi.org/10.1373/clinchem.2009.124370.
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Abstract Background: The prognostic value of changes in paraprotein markers after stem cell transplantation is unknown. We evaluated disease response using serum immunofixation (s-IFIX), total κ and λ ratio (KLR), and free light chain (FLC) ratio in myeloma patients who underwent autologous or autologous plus allogeneic stem cell transplantation. Methods: We studied s-IFIX, KLR, and FLC ratio in sera from 203 patients, 3 months after transplantation. We evaluated overall and event-free survival (OS and EFS, interval between date of study enrollment and date of death from any cause or date of progression, relapse, or death from any cause, respectively) by the Kaplan–Meier method. Results: Of the 203 patients, 51 were negative by s-IFIX, 99 reached a normal KLR, and 92 had a normal FLC ratio. Of the 51 patients with negative s-IFIX, 40 (78%) also had a normal FLC ratio. The median duration of OS was 54.3 months, and the median EFS was 19.5 months. None of the measured paraprotein parameters showed an association with OS. Only a normal KLR was associated with prolonged EFS (P = 0.016). Even a negative s-IFIX associated with a normal FLC ratio did not show a significant difference in terms of EFS and OS. Conclusions: Our analysis with a small cohort of patients did not show a significant impact of achieving complete response (CR) or stringent CR on patient survival.
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Gualpa-Naranjo, Kenneth, Daniela Valencia-Paredes, Daniel Barrera-Sandoval, Daniel Robles-Luna, Kevin Portocarrero-Montoya, Ronnie Rodríguez-Armijos i Carlos Ramos-Galarza. "Las funciones ejecutivas y la regulación del aprendizaje de universitarios". Wimb Lu 14, nr 1 (9.04.2019): 127–37. http://dx.doi.org/10.15517/wl.v14i1.36906.
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Esta investigación realizó un análisis correlacional entre las funciones ejecutivas (conducta con iniciativa, capacidad para la planificación y la capacidad para supervisar y monitorizar la cognición) y la autorregulación del aprendizaje (gestión de la planificación y gestión de la motivación) en una muestra de 203 estudiantes universitarios entre 18 y 25 años de edad (Medad = 20.53, DE = 1.77), 109 hombres (53.7%) y 94 mujeres (47.3%). En los resultados se encontraron relaciones significativas entre: gestión de la motivación y capacidad para la planificación (r = .49, p = <.001), gestión de la motivación y conducta con iniciativa (r = .464, p = <.001), gestión de la planificación y capacidad para supervisar y monitorizar la cognición (r = .51, p = <.001). No se encontraron diferencias significativas al comparar las variables dependientes según el género o estado civil (t(201) = .07, p =.79), lateralidad (t(201)= 1.46, p =.22), género o carrera (x2(203) =11.88, p =.04) y tiempo de estudio (x2 (203) = 1.55, p =.46). Como conclusión, se sugiere que las funciones ejecutivas tienen una correlación moderada con el aprendizaje de los universitarios, mismas que en conjunto con la autorregulación del aprendizaje, aportan de manera significativa, para que el universitario presente un mejor rendimiento académico. Se cierra el reporte, resaltando la necesidad de realizar más investigaciones en esta temática para el beneficio de los universitarios.
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Courtenay, Kenneth P., i John P. Stephens. "The experience of patient suicide among trainees in psychiatry". Psychiatric Bulletin 25, nr 2 (luty 2001): 51–52. http://dx.doi.org/10.1192/pb.25.2.51.
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Aims and MethodWe set out to ascertain how common this is for psychiatric trainees in South Thames and the effects it has, if any. An anonymous postal questionnaire was circulated to 400 trainees.ResultsOf the 400 trainees, 203 (51%) responded and 109 (54%) of the respondents had had one or more patient suicide and 168 suicides were reported.We judged the effect of the suicide on the doctor to be moderate or severe in 126 (75%) of the 168 suicide events.Clinical ImplicationsPatient suicide must have a higher profile in training. Formal systems need to be created to provide support and education in this area.
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Shapiro, Edward P., i Frank E. Rademakers. "Importance of oblique fiber orientation for left ventricular wall deformation". Technology and Health Care 5, nr 1-2 (1.03.1997): 21–28. http://dx.doi.org/10.3233/thc-1997-51-203.
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Heveker, Nikolaus, Arne Hansen, Klaus-Dieter Hungerer, Rüdiger von Baehr i Ralf W. Glaser. "A human monoclonal antibody with the capacity to neutralize Staphylococcus aureus alpha-toxin". Human Antibodies 5, nr 1-2 (1.03.1994): 18–24. http://dx.doi.org/10.3233/hab-1994-51-203.
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Burkhart, L. M. "Women Who Live Evil Lives: Gender, Religion, and the Politics of Power in Colonial Guatemala; Transcending Conquest: Nahua Views of Spanish Colonial Mexico". Ethnohistory 51, nr 1 (1.01.2004): 203–5. http://dx.doi.org/10.1215/00141801-51-1-203.
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Bush, R. M., i K. D. Everett. "Molecular evolution of the Chlamydiaceae." International Journal of Systematic and Evolutionary Microbiology 51, nr 1 (1.01.2001): 203–20. http://dx.doi.org/10.1099/00207713-51-1-203.
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Ritter, E., i K. Wimmers. "Mitteilung der Redaktion". Archives Animal Breeding 51, nr 2 (10.10.2008): 203. http://dx.doi.org/10.5194/aab-51-203-2008.
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Abdul-Razzak, Khalid K., Abeer M. Khoursheed, Shoroq M. Altawalbeh, Bayan A. Obeidat i Mohammed-Jafar A. Ajlony. "Hb level in relation to vitamin D status in healthy infants and toddlers". Public Health Nutrition 15, nr 9 (6.03.2012): 1683–87. http://dx.doi.org/10.1017/s1368980012000730.
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AbstractObjectiveTo assess the presence of an association between vitamin D deficiency and anaemia in Jordanian infants and toddlers, in whom both vitamin D deficiency and anaemia have previously been proved to be common separately.DesignCross-sectional prospective study.SettingDepartment of Paediatrics, Princess Rahma Teaching Hospital, Jordan.SubjectsHealthy infants and children aged 6–36 months who were seen for primary care.ResultsOut of 203 infants and toddlers included in the study, the anaemia prevalence was 40·4 %. The prevalence of anaemia among infants (n 110) was 51·8 %, whereas it was 26·9 % among toddlers (n 93). No association between vitamin D status and anaemia was found.ConclusionsVitamin D deficiency is not a risk for anaemia in infants and toddlers.
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MacNeil-Covin, Lisa, Alan G. Casson, Dickran Malatjalian i Sander Veldhuyzen van Zanten. "A Survey of Canadian Gastroenterologists about the Management of Barrett’s Esophagus". Canadian Journal of Gastroenterology 17, nr 5 (2003): 313–17. http://dx.doi.org/10.1155/2003/648497.
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The aims of the present study were to determine practice patterns of Canadian gastroenterologists for screening patients with Barrett’s esophagus and to compare current practice patterns with published guidelines. A secondary goal was to evaluate whether gastroenterologists recommend a ’once in a lifetime’ endoscopy for patients with chronic gastroesophageal reflux disease. A structured questionnaire regarding screening for Barrett’s esophagus was sent to members of the Canadian Association of Gastroenterology. The overall response rate was 51% (203 of 396). Of the 203 respondents, 165 (81%) performed endoscopies in adults and form the basis of this report. The majority of Canadian gastroenterologists followed published guidelines, with 62% screening patients without dysplasia every two years. Patients with low grade dysplasia were screened more frequently, with 54% of respondents performing endoscopy every six months, and 35% on a yearly basis. Biopsy protocols showed the greatest variation, with 46% of gastroenterologists taking four-quadrant biopsies at 2 cm intervals along the columnar-lined (Barrett’s) esophagus. Seventy-six per cent of gastroenterologists agreed that all patients with chronic gastroesophageal reflux should have a ’once in a lifetime’ endoscopy to screen for Barrett’s esophagus. The majority of Canadian gastroenterologists follow current guidelines for the management of Barrett’s esophagus and support the concept of ’once in a lifetime’ endoscopy.
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Rasmussen, Theodore. "Surgery for Central, Parietal and Occipital Epilepsy". Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 18, S4 (listopad 1991): 611–16. http://dx.doi.org/10.1017/s0317167100032820.
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ABSTRACT:Patients with epileptogenic lesions that are more or less restricted to the central, parietal or occipital regions represent 14% of our total epilepsy surgery series and consisted of 322 patients at the end of 1980. Tumoral or major vascular lesions were present in 117 patients (37%), but this report is limited to the remaining 203 patients (63%) with non-tumoral epileptogenic lesions. The presumed etiology was birth trauma or anoxia in 25%, postnatal brain trauma in 25%, and unknown in 24%, miscellaneous lesions were present in 16%, post-inflammatory gliosis or multiple factors were present in the remaining 10%. Follow-up data of 2-51 years' duration (median 18 years) are available for 186 of these 203 patients. Sixty-three patients (34%) remain seizure-free. Forty-two patients (23%) have a marked reduction of seizures. The remaining 81 patients (44%) have a lesser reduction. The variation in clinical seizure patterns is considerably greater than in temporal lobe epilepsy. Focal sensorimotor phenomena are common at the onset, whether the seizures begin in the central region or further posterior. The success following cortical resection is equally gratifying and the failures just as distressing as in surgery for epilepsy involving other brain regions.
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Grabau, Morgan, Karla Wilke i Mary E. Drewnoski. "75 Management of the Young Calf When Dams Are Limit-fed in Confinement". Journal of Animal Science 99, Supplement_1 (1.05.2021): 116–17. http://dx.doi.org/10.1093/jas/skab054.193.
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Abstract Limit-feeding cows in confinement can lower feed costs; however, calves have limited time to access feed. This study was designed to evaluate management options to economically improve calf performance. Calves (n = 54) were stratified by age (105 ± 16 DOA) and assigned randomly to one of nine groups, then each group assigned randomly to one of three treatments: 1) kept with dam with access to cow diet only (PAIRS) 2) early-weaned (EW) or 3) kept with dam with access to creep (CREEP). The cow diet was 54% wet distillers grains (WDGS), 37% straw, and 8% corn. This diet was fed to meet dry cow requirements (7.7 kg DM/d) for EW, lactation requirements (10.9 kg DM/d) in CREEP, and lactation requirements plus allow for some calf intake (14.8 kg DM/d) in PAIRS. The calf diet consisted of 51% alfalfa hay, 25% WDGS, and 22% corn. Calves in the EW had greater (P < 0.01) intake (5.0 kg DM/d) than CREEP (4.1 kg DM/d) from 105 to 203 DOA. Calf ADG differed (P < 0.01) among treatments from 105 to 203 DOA, with CREEP (1.29 kg/d) being greater (P = 0.02) than EW (1.01 kg/d) and both being greater (P ≤ 0.02) than PAIRS (0.74 kg/d). At ~203 DOA, PAIRS and CREEP were weaned and all calves were fed a growing diet. Calf intakes during the growing phase (223 to 314 DOA) did not differ (P = 0.39). However, calf ADG tended (P < 0.06) to differ. The ADG of PAIRS (1.13 kg/d) and EW (1.10 kg/d) did not differ (P = 0.67) but were greater (P ≤ 0.05) than CREEP (0.92 kg/d). However, when calf value and total feed costs were considered, creep resulted in the most return over feed costs at weaning as well as at the end of growing.
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Barua, H., MM Alam Patwary i MH Rahman. "Performance Of Bari Mango (Mangifera indica L.) Varieties In Chittagong Region". Bangladesh Journal of Agricultural Research 38, nr 2 (28.07.2013): 203–9. http://dx.doi.org/10.3329/bjar.v38i2.15883.
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Five mango varieties developed by Bangladesh Agricultural Research Institute (BARI) were evaluated at ARS, Pahartali, Chittagong during January to June 2012 to find out the suitable variety. The earliest flowering as well as harvesting were observed in BARI Aam-1 and the latest in BARI Aam-8. Number of fruits per tree varied from 51 to 117. Maximum number of fruits (117) per tree was obtained from BARI Aam-8, while minimum fruits (51) from BARI Aam-4 (Hybrid). The heaviest fruit (373.0 g) was obtained from BARI Aam-4 (Hybrid), while the lightest fruit (172.6 g) was in BARI Aam-3. Maximum yield per plant was found in BARI Aam-8 (33.59 kg) followed by BARI Aam-4 (19.02 kg), whereas it was lowest in BARI Aam-1(14.42 kg). The highest edible portion (78.66 %) was recorded in BARI Aam-4, while the lowest (65.99%) was obtained from BARI Aam-1. The highest TSS content (21.36%) was recorded in BARI Aam-3, whereas the lowest TSS content (16.51%) was observed in BARI Aam-2. Bangladesh J. Agril. Res. 38(2): 203-209, June 2013 DOI: http://dx.doi.org/10.3329/bjar.v38i2.15883
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De Opinión Pública, Instituto Universitario. "El sistema político salvadoreño a finales de 1995. Sondeo de opinión pública". ECA: Estudios Centroamericanos 51, nr 569 (31.03.1996): 179–203. http://dx.doi.org/10.51378/eca.v51i569.5955.
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Entre el 21 y el 28 de octubre de 1995, el IUDOP realizó una encuesta de opinión pública con una muestra de 1,222 adultos, representativa de la población total de El Salvador y con un margen de error del 4 por ciento. El sondeo, diseñado para recoger la opinión de los ciudadanos sobre el contexto político salvadoreño y para adelantar las preferencias de los salvadoreños por las opciones políticas, mostró que la mayoría de los ciudadanos sigue teniendo poco interés en la política, desconfía de las instituciones gobernantes y de representación política y está sumamente preocupada por la falta de respuestas a sus problemáticas cotidianas, lo que genera condiciones muy riesgosas para el proceso de transición política salvadoreño.
ECA Estudios Centroamericanos, Vol. 51, No. 569, 1996: 179-203.
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Bolin, Steven R., i Julia F. Ridpath. "Prevalence of Bovine Viral Diarrhea Virus Genotypes and Antibody against those Viral Genotypes in Fetal Bovine Serum". Journal of Veterinary Diagnostic Investigation 10, nr 2 (kwiecień 1998): 135–39. http://dx.doi.org/10.1177/104063879801000203.
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One thousand lots of pooled fetal bovine serum (FBS) were tested for contamination with bovine viral diarrhea virus (BVDV) and/or for contamination with neutralizing antibody against BVDV. Noncytopathic or cytopathic BVDV was isolated from 203 lots of FBS. Analysis of the viral isolates identified 115 type 1 and 65 type 2 BVDV isolates. An additional 23 virus isolates were mixtures of >2 BVDV isolates and were not classified to viral genotype. Further characterization of the type 1 viruses identified 51 subgenotype 1a and 64 subgenotype 1b BVDV isolates. Viral neutralizing antibody was detected in 113 lots of FBS. Differential viral neutralization indicated that type 1 BVDV induced the antibody detected in 48 lots of FBS and type 2 BVDV induced the antibody detected in 16 lots of FBS.
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Anansitthikorn, Natthakrit, i Suchanan Hanamornroongruang. "Two-Antibody Staining Method, A Cost-Saving Strategy for Universal Lynch Syndrome Screening in Endometrial Cancers". Siriraj Medical Journal 74, nr 2 (1.02.2022): 108–13. http://dx.doi.org/10.33192/smj.2022.14.
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Objective: Lynch syndrome is an autosomal dominant disorder that increases the risk of cancers in many sites. In women, endometrial cancer is often a sentinel tumor and thus immunohistochemistry for mismatch repair (MMR) proteins MLH1, MSH2, MSH6 and PMS2 is encouraged as a screening test. To reduce cost, staining for only 2 MMR proteins PMS2 and MSH6 has been proposed. This study aimed to determine whether a 2-antibody staining test is enough to screen for Lynch syndrome in endometrial cancer patients.Materials and Methods: Cases of endometrial carcinoma with immunohistochemistry for 4 MMR proteins were reviewed. Results of immunohistochemistry screening were compared between all four antibodies and only two (PMS2 and MSH6) antibodies.Results: Loss of expression of any MMR proteins was detected in 51 out of 203 cases (25.12%). Twenty-three cases (45%) showed loss of MLH1 and PMS2; 13 cases (25%) showed loss of MSH2 and MSH6; five cases (10%) showed loss of MSH6; seven cases (14%) showed loss of PMS2 and three cases (6%) showed loss of MSH2. The 2-antibody method detected 48 cases (94%) with a MMR deficiency but failed to detect three cases (6%) with an isolate loss of MSH2. The screening results from the 2-antibody method are 98.5% (200/203) in accordance with the original 4-antibody method.Conclusion: The 2-antibody method is a quite effective option to screen for Lynch syndrome in endometrial cancers. However, MSH2 mutations may be missed in a few cases.
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Шамкалович, А. В., А. А. Боровский, Н. С. Жилинский, В. Л. Василенок i Д. В. Алексеевский. "Rare Tumors of the Central Nervous System: Medulloblastoma of the Adult Population in the Republic of Belarus". Неврология и нейрохирургия. Восточная Европа, nr 2 (15.07.2020): 178–95. http://dx.doi.org/10.34883/pi.2020.2.2.013.
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Введение. Медуллобластома (МДБ) – наиболее часто встречающаяся в нейрохирургической практике высокозлокачественная опухоль головного мозга у детей. У взрослых МДБ возникают относительно редко и составляют не более 4% от всех первичных опухолей головного мозга. Рекомендаций, протоколов лечения МДБ взрослого населения в настоящее время не создано как в Республике Беларусь, так и в ближайшем зарубежье. Пациентов чаще лечат по педиатрическим протоколам. С целью улучшения качества нейроонкологической помощи взрослому населению необходима разработка рекомендаций лечения пациентов с МДБ и другими редкими первичными опухолями ЦНС. Реализация этой задачи не будет считаться полной без анализа существующей на данный момент картины заболеваемости.Цель исследования: выявление прогностических факторов, влияющих на показатели выживаемости у пациентов старше 18 лет с МДБ.Материалы и методы. Ретроспективный анализ данных канцер-регистра, полученных в ГУ «РНПЦ ОиМР им. Александрова» за все время наблюдения с 1980 по 2019 г. Проанализировали 203 пациентов старше 18 лет с гистологически верифицированным диагнозом «медуллобластома». Для анализа применяли методы описательной статистики, методы корреляционного и регрессионного анализов.Результаты. Проанализировано 203 пациента, 74 (36,45%) женщины и 129 (63,55%) мужчин. Средний возраст на момент обнаружения МДБ составил 37,9 (25, 51) года. Однолетняя общая выживаемость составила 65% пациентов, пятилетняя общая – 30,5% пациентов. Медиана выживаемости составила 131 неделю (2,5 года). Согласно регрессионному и корреляционному анализам, химиотерапия и лучевая терапия оказались эффективнее хирургического удаления опухоли как методы лечения МДБ. Возраст младше 50 лет и наличие адъювантной химиотерапии являются наиболее существенными факторами выживаемости пациентов. Метастатическое распространение опухолевого процесса наблюдалось у 28 пациентов.Выводы. Требуется актуализация клинических протоколов лечения с учетом расширившихся возможностей ИГХ-исследования. Пациентам следует проводить комплексное лечение, включающее оперативное лечение, адъювантное лучевое и химиотерапевтическое лечение. Introduction. Medulloblastoma (MDB) is the most common high malignant brain tumor in children in neurosurgical practice. In adults, MDBs are relatively rare and make up no more than 4% of all primary brain tumors. Recommendations, treatment protocols for MDBs of the adult population have not yet been created both in the Republic of Belarus and in the neighboring countries. Patients are often treated according to pediatric protocols. In order to improve the quality of neuro- oncological care for the adult population, it is necessary to develop recommendations for the treatment of patients with MDB and other rare primary CNS tumors. The implementation of this task will not be considered complete without an analysis of the current incidence picture.The purpose of this work was to identify prognostic factors affecting survival rates in patients over 18 years of age with MDB.Materials and methods. A retrospective analysis of the data of the cancer register obtained in the State Institution “N. N. Alexandrov National Cancer Centre” for the entire time of observation from 1980 to 2019. We analyzed 203 patients over 18 years old with a histologically verified diagnosis of Medulloblastoma. For the analysis, methods of descriptive statistics, methods of correlation and regression analyzes were used.Results. We analyzed 203 patients, 74 (36.45%) women, and 129 (63.55%) men. The average age at the time of detection of the MDB was 37.9 (25, 51) years. One-year overall survival was 65% of patients, five-year overall survival was 30.5% of patients. Median survival was 131 weeks (2.5 years). According to regression and correlation analyzes, chemotherapy and radiation therapy were more effective than surgical removal of the tumor as a treatment for MDB. Age under 50 years and the presence of adjuvant chemotherapy are the most significant factors in patient survival. Metastatic spread of the tumor process was observed in 28 patients.Conclusion. The actualization of clinical treatment protocols is required, taking into account the expanded capabilities of the IHC study. Patients should undergo complex treatment, including surgical treatment, adjuvant radiation, and chemotherapeutic treatment.
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Nguyễn Quang Thiều, Hoàng Đình Cảnh i Hà Tấn Dũng. "BẢN ĐỒ PHÂN BỐ MUỖI, BỌ GẬY Aedes aegypti, Aedes albopictus VÀ TRƯỜNG HỢP BỆNH SỐT XUẤT HUYẾT DENGUE TẠI HÀ NỘI, GIAI ĐOẠN 2018 - 2020". TẠP CHÍ PHÒNG CHỐNG BỆNH SỐT RÉT VÀ CÁC BỆNH KÝ SINH TRÙNG 134, nr 2 (2.07.2023): 29–37. http://dx.doi.org/10.59253/tcpcsr.v134i2.114.
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Xây dựng bản đồ phân bố muỗi, bọ gậy Aedes và trường hợp bệnh sốt xuất huyếtdengue (SXHD) tại 583 điểm (xã/phường) tại 30 quận/huyện của thành phố Hà Nội đượcthực hiện từ năm 01/2018 đến tháng 12/2020. Kết quả cho thấy: năm 2018, 174 điểm(xã/phường) không có trường hợp bệnh, 393 điểm có từ 1-50 trường hợp bệnh, 13 điểmcó từ 51-100 trường hợp bệnh và chỉ tại 3 điểm có trên 100 trường hợp bệnh. Năm 2019,78 điểm không có trường hợp bệnh, 426 điểm có từ 1-50 trường hợp bệnh, 59 điểm cótừ 51-100 trường hợp bệnh và 203 điểm có trên 100 trường hợp bệnh. Năm 2020, 111điểm không có trường hợp bệnh, 452 điểm có từ 1-50 trường hợp bệnh, 15 điểm có từ51-100 trường hợp bệnh và 5 điểm có trên 100 trường hợp bệnh. Kết quả điều tra chỉsố muỗi, bọ gậy Aedes cho thấy: tại tất cả các điểm điều tra có trường hợp bệnh đềuphát hiện sự có mặt muỗi Aedes. Các điểm có các chỉ số muỗi, bọ gậy loài Ae. aegypticao hơn so với Ae. albopictus thì đa số có số lượng trường hợp bệnh SXHD cao
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Kisyński, Jan. "Metrization of D_E[0,1] by Hausdorff distance between graphs". Annales Polonici Mathematici 51, nr 1 (1990): 195–203. http://dx.doi.org/10.4064/ap-51-1-195-203.
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Мизаев, М. М., i А. М. Мизаев. "ЦИФРОВЫЕ ТЕХНОЛОГИИ В УПРАВЛЕНИИ КАЧЕСТВОМ". Тенденции развития естественных наук в современном информационном пространстве и их применение в агробиотехнологиях, nr 1 (22.10.2021): 203–6. http://dx.doi.org/10.36684/51-2021-1-203-206.
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Одним из направлений повышения эффективности промышленности является применение современных информационных технологий для интеграции процессов, выполняющихся в ходе всего жизненного цикла продукции и ее компонентов. Развитие цифровых технологий привело к изменению взглядов на современные технологии. Это особенно характерно для высокотехнологичных отраслей, например, авиаракетостроения, военной техники и вооружений, атомного машиностроения, робототехники и т.д.
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Wang, L. S., C. Chen, M. K. Kaban, J. S. Du, Q. Liang i M. Thomas. "The use of the A10-022 absolute gravimeter to construct the relative gravimeter calibration baselines in China". Metrologia 51, nr 3 (1.05.2014): 203–11. http://dx.doi.org/10.1088/0026-1394/51/3/203.
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Lim, Sook Yee, Yoke Mun Chan, Vasudevan Ramachandran, Zalilah Mohd Shariff, Yit Siew Chin i Manohar Arumugam. "No Interaction Effect between Interleukin-6 Polymorphisms and Acid Ash Diet with Bone Resorption Marker in Postmenopausal Women". International Journal of Environmental Research and Public Health 18, nr 2 (19.01.2021): 827. http://dx.doi.org/10.3390/ijerph18020827.
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Background: Evidence is growing that a high-acid diet might accelerate the rate of bone loss, and gene polymorphisms such as Interleukin 6 (IL6) -174G/C and -572G/C are related to bone deterioration. However, no study of the interaction between diet and IL6 polymorphisms has been conducted among Asians. Thus, the objective of this study was to determine whether IL6 gene polymorphisms modified the association between dietary acidity and the rate of bone resorption. Methods: This cross-sectional study recruited 203 postmenopausal women (age ranged from 51 to 85 years old) in community settings. The dietary intakes of the participants were assessed using a validated interviewer-administered semi-quantitative food frequency questionnaire (FFQ), while dietary acid load (DAL) was estimated using net endogenous acid production (NEAP). Agena® MassARRAY genotyping analysis and serum collagen type 1 cross-linked C-telopeptide (CTX1) were used to identify the IL6 genotype and as a bone resorption marker, respectively. The interactions between diet and single-nucleotide polymorphisms (SNPs) were assessed using linear regressions. Results: A total of 203 healthy postmenopausal women aged between 51 and 85 years participated in this study. The mean BMI of the participants was 24.3 kg/m2. In IL6 -174 G/C, all the participants carried the GG genotype, while the C allele was absent. Approximately 40% of the participants had a high dietary acid load. Dietary acid load (B = 0.15, p = 0.031) and the IL6 -572 CC genotype group (B = 0.14, p = 0.044) were positively associated with a higher bone resorption. However, there was no moderating effect of the IL6 genetic polymorphism on the relationship between and acid ash diet and bone resorption markers among the postmenopausal women (p = 0.79). Conclusion: High consumption of an acid ash diet and the IL6 -572 C allele seem to attribute to high bone resorption among postmenopausal women. However, our finding does not support the interaction effect of dietary acidity and IL6 (-174G/C and -572G/C) polymorphisms on the rate of bone resorption. Taken together, these results have given scientific research other candidate genes to focus on which may interact with DAL on bone resorption, to enhance planning for preventing or delaying the onset of osteoporosis among postmenopausal women.
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Jaster, Christian, i Thomas Ellwart. "Dem Fachkräftemangel das Handwerk legen". Zeitschrift für Arbeits- und Organisationspsychologie A&O 66, nr 2 (kwiecień 2022): 100–110. http://dx.doi.org/10.1026/0932-4089/a000380.
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Zusammenfassung. Der Fachkräftemangel stellt besonders im Handwerk große Anforderungen an die Führungskräfte. Um Führungskräfte im Handwerk bei der mitarbeiterorientierten Führung zu unterstützen, wurde ein Instrument zur bedürfnisorientierten Arbeitsanalyse (MotivSORT) entwickelt und pilotiert. Mit MotivSORT befragen Führungskräfte die Mitarbeitenden zu 15 Arbeitsmerkmalen auf den Dimensionen (1) Wichtigkeit und (2) Ausprägung im Arbeitsalltag. Die Validität und Akzeptanz von MotivSORT wurde in zwei Studien mit Mitarbeitenden im Handwerk ( N1 = 51; N2 = 203) untersucht. Eine Überprüfung des formativen Messmodells zeigte Konvergenzvalidität und erwartungskonforme Zusammenhänge zwischen der Ausprägung bedürfnisbezogener Arbeitsmerkmale und Indikatoren der Mitarbeitendenbindung (z. B. Arbeitszufriedenheit, affektive Bindung, Kündigungsabsicht). Zudem zeigte sich eine hohe Akzeptanz von MotivSORT seitens der Mitarbeitenden auf den Dimensionen Nützlichkeit, Einfachheit der Anwendung, Arbeitsplatzrelevanz und Nutzungsabsicht. MotivSORT wird aktuell in der Betriebsberatung der Handwerkskammern Rheinland-Pfalz zur mitarbeiterorientierten Führung sowie Organisationsdiagnose implementiert. Perspektivisch wird die Anwendung auf weitere Branchen und organisational relevante Themen wie Personalauswahl und Veränderungsprozesse erweitert.
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Silva, Francicléia Lopes, Heloisa Barbára Cunha Moizéis, Gleidson Diego Lopes Loureto, Alessandro Teixeira Rezende i Valdiney Veloso Gouveia. "Escala de Percepção de Causas do Estupro (EPCE)". Psico 52, nr 2 (15.07.2021): e36079. http://dx.doi.org/10.15448/1980-8623.2021.2.36079.
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Foram realizados dois estudos com estudantes universitários a fim de reunir evidências psicométricas da adaptação da Escala de Percepção de Causas do Estupro (EPCE) ao contexto brasileiro. O Estudo 1 contou com 220 pessoas com idade média de 23,5 anos (DP = 7,56; variaram de 18 a 63 anos) (64,5% do sexo feminino), enquanto no Estudo 2 participaram 203 indivíduos com idade média de 21,4 anos (DP = 5,17; variaram de 18 a 51 anos) (54,2% do sexo feminino), todos responderam perguntas demográficas, a EPCE e uma medida de atitudes negativas frente a vítimas de estupro. As análises corroboraram a estrutura fatorial de 5 componentes, com índices de consistência interna variando entre 0,92 e 0,70. Ademais, observou-se uma correlação positiva da EPCE com atitudes negativas frente a vítimas (validade convergente). Concluindo, esta escala apresentou evidências de validades fatorial e convergente, além de consistência interna, apoiando seu uso em estudos futuros.
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Steudel, Ralf, Torsten Sandow i Jürgen Steidel. "Darstellung und Eigenschaften von cyclo-Nonaschwefeloxid (S9O) und von cyclo-Dekaschwefeloxid (S10O) [1] / Preparation and Properties of cyclo-Nonasulfuroxide (S9O) and of cyclo-Decasulfuroxide (S10O) [1]". Zeitschrift für Naturforschung B 40, nr 5 (1.05.1985): 594–600. http://dx.doi.org/10.1515/znb-1985-0507.
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Abstract The homocyclic oxides S9O (m.p. 33 °C, dec.) and S10O (m.p. 51 °C, dec.) have been prepared by oxidation of the corresponding sulfur rings S9 and S10 , respectively, by trifluoroperoxy acetic acid (molar ratio 1:2-3) in a carbon disulfide/methylene chloride mixture. According to infrared and Raman spectra, both compounds contain an exocyclic oxygen atom. S9O and S10O decompose at 25 °C to give SO2 and a polysulfuroxide SnO with >10 but both can be stored at -78 °C without decomposition. The SS bond distances are discussed on the basis of the Raman spectra. In addition, the Raman spectrum of solid S9 has been recorded for the first time. It shows that S9 crystallizes as two allotropes (α-and β-S9) both consisting of cyclic molecules of either C1 or C2 symmetry with bond distances of between 203 and 209 pm.
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Rouf, MA, MS Islam, T. Rabeya, AK Mondal, M. Khanam, PR Samadder i Y. Ara. "Biogas from slaughter house waste and optimization of the process". Bangladesh Journal of Scientific and Industrial Research 51, nr 3 (5.09.2016): 203–14. http://dx.doi.org/10.3329/bjsir.v51i3.29432.
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To assess the potential of biogas generation by anaerobic digestion from slaughter house waste (undigested stomach content) and to determine the optimum conditions for biogas generation from the substrate, different proportions of substrate were used in six batch reactors R1, R2, R3, R4, R5 and R6. The reactors were operated with initial volatile solid concentrations of 34.00, 50.80, 67.20, 51.60, 48.10 and 63.36 g/l and corresponding specific gas production obtained was 0.258, 0.200, 0.160, 0.270, 0.201 and 0.170 l/g respectively. The volatile solids (VS) destruction efficiency was 31.71%, 29.15%, 28.26%, 32.29%, 30.56 and 29.08% as well as chemical oxygen demand (COD) reduction achieved in the test reactors were 40.31%, 44.44%, 49.40%, 53.24%, 48.55% and 51.26% in R1, R2, R3, R4, R5 and R6 respectively. Methane yield in different reactors varied from 72% to 76%. The optimum mix for generation of biogas from the substrate was 75% slaughter waste mixed with 25% cow dung.Bangladesh J. Sci. Ind. Res. 51(3), 203-214, 2016
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Welch-Brewer, Chiquitia. "Risk-Need Profiles of Serious and Chronic Female Juvenile Offenders: Implications for Female Juvenile Correctional Programming". International Journal of Offender Therapy and Comparative Criminology 62, nr 9 (31.10.2017): 2742–58. http://dx.doi.org/10.1177/0306624x17735055.
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Understanding differences and similarities between male and female juvenile offenders is critically important for determining the treatment needs of each group. Less is known, however, about the similarities and differences among female juvenile offenders and the variation in their needs, risks, and psychosocial profiles. Understanding the variation among female juvenile offenders could lead to improvements in gender-responsive interventions and treatment. Latent profile analysis was conducted to construct risk-need profiles in a state-based sample of incarcerated girls ( N = 203) based on a range of psychosocial subscales covering family, peer, school and cognitive and emotional processes, psychopathology, and antisocial outcomes. Findings revealed four distinct groups/profiles with varying levels of risk-needs— Aggression Only (51%), Alcohol and Drug Use (19%), Socioemotional and Family Relationship Problems (24%), and Severe Alcohol and Drug Use (6%)—warranting the need for varying levels of treatment intensity and different treatment components across subgroups, ranging from less to more extensive.
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ErickTandi, Tinyami, Tinyami ErickTandi, Tinyami ErickTandi, KyungHee Kim, Tambetakaw Njang Gilbert, JaeWook Choi i JaeWook Choi. "Motorcycle-Related Head and Limbs Injuries from Road Traffic Accident at a Second Level Hospital in Cameroon". Journal of Preventive Medicine And Care 2, nr 3 (8.03.2019): 20–28. http://dx.doi.org/10.14302/issn.2474-3585.jpmc-19-2633.
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Motorcycles have been increasing used widely in various urban, suburban and villages in Cameroon with an increased in accidents resulting to injuries among the population. Head and limbs injuries are responsible for most of the cases encountered from related crashes. A prospective study on head and limbs injuries resulting from motorcycle crash were assessed among the different cases brought to the casualty and emergency department of the Kumba district hospital. Most of the injured cases were of motorcycle and other vehicle collisions 203 (47.65) and the least among motorcycle lone crash 51 (11.97). Motorcycle to motorcycle collisions accounted for 107 (25.12 %) of the cases. 65 (15.26%) were motorcycle with pedestrians related collision. Stepping up and facilitating the regulations on licenses and the use of personal protective equipment for riders, improvement of roads infrastructures with pedestrian path, expanding health facilities and equipment, and human resources for health as well as empowering the population on road safety measures will be very important for RTAs control measures of the nation.
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Hansmeier, Jana, Cornelia Exner, Winfried Rief i Julia Glombiewski. "Gedanken-Handlungs-Fusion und Zwangssymptome–eine Validierungsstudie der Thought Action Fusion-Skala (TAF-Skala) für den deutschen Sprachraum". Zeitschrift für Klinische Psychologie und Psychotherapie 43, nr 3 (lipiec 2014): 204–14. http://dx.doi.org/10.1026/1616-3443/a000266.
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Theoretischer Hintergrund: Dysfunktionale Annahmen über die Beziehung zwischen mentalen Ereignissen und Verhaltensweisen, sogenannte Gedanken-Handlungs-Fusionen, nehmen eine wichtige Rolle insbesondere in der Erforschung von Zwangssymptomen ein. Fragestellung: Struktur und psychometrische Eigenschaften der deutschen Version der „Thought Action Fusion Skala” (TAF-Skala) zur Erfassung von Gedanken-Handlungs-Fusionen wurden untersucht. Methode: Überprüft wurden verschiedene Gütekriterien an einer klinischen Stichprobe von 203 Probanden (davon 71 mit Zwangsstörung, 51 mit Angststörungen und 81 mit einer Major Depression) und einer nicht-klinschen Stichprobe (n = 300). Ergebnisse: Die Originalstruktur mit drei Skalen konnte in explorativen und konfirmatorischen Faktoranalysen bestätigt werden. Interne Konsistenzen und Retest-Reliabilitäten waren zufriedenstellend bis sehr gut, die diskriminate und konvergente Validität bedingt zufriedenstellend. Die TAF-Skala konnte gut zwischen klinischen und nicht-klinischen Probanden unterscheiden, allerdings nicht zwischen verschiedenen klinischen Stichproben. Schlussfolgerungen: Die deutsche Version der TAF-Skala ist ein zu großen Teilen valides und reliables, aber nicht zwangsspezifisches Messinstrument zur Erfassung von Gedanken-Handlungs-Fusionen und für den Einsatz in Forschung und Praxis geeignet.
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Chaiyasaen, Natthakorn, Kochakorn Direksin, Nutravong Thitima i Suttisak Nopwinyoowong. "Prevalence, antibiograms, antibiotic resistance genes, and virulence genes of Arcobacter butzleri isolated from healthy pigs in mid-northeastern Thailand". Veterinary Integrative Sciences 21, nr 2 (20.02.2023): 309–31. http://dx.doi.org/10.12982/vis.2023.024.
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Pigs can have Arcobacter butzleri. However, information on A. butzleri in Thai pigs remains scarce. This work aimed to survey A. butzleri in healthy pigs and assess their antimicrobial susceptibility, potential transferrable antimicrobial resistance (AMR) genes, and virulence-associated genes (VAGs). Cross-sectional fecal samples of 203 pigs from 18 farms were cultured and molecularly identified. A. butzleri prevalence in all pigs was (31/203; 15.3%): nursery (0/8; 0%), finisher (27/144; 18.8%), and sow (4/51; 7.8%). The total farm A. butzleri prevalence was 50%: nursery (0/2: 0%), finisher (8/14: 57.1%), and sow (2/9: 22.2%) farms. From the 10 antibiotic disks evaluated, the isolates were mostly sensitive to imipenem (96.8%), tetracycline (83.9%), streptomycin (67.7%), and amoxycillin/clavulanic acid (54.8%); however, they were mostly resistant to cefotaxime (98.6%), sulbactam/cefoperazone (71%), ampicillin (67.7%), enrofloxacin (48.4%), and fosfomycin (42.9%) and were neither sensitive nor resistant to erythromycin. Most multidrug resistance patterns in this study were in four to six classes. Three isolates resisted all 10 antibiotics. However, only the TetO gene was detected in one isolate, whereas ESBLs (SHV, CTX-M, and TEM), PMQRs (qnrA, qnrS, qnrB, oqxAB, and aac(6’)-Ib-cr), ermB, and mefA genes were not found in any isolates. The rankings of VAGs presented in the isolates were ciaB (100%), mviN (97%), pldA (93%), tlyA (90%), cj1349 (90%), cadF (83%), hecB (10%), hecA (7%), and irgA (0%), and most isolates carried six VAGs (77%). A. butzleri is present in healthy pigs, and this database is the first to show A. butzleri VAG and AMR genes in Thai pigs
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Kroll, Michael H., Naresh Pemmaraju, Thein H. Oo, Vahid Afshar-Kharghan i Samantha Kroll. "Mortality from Cancer-Associated Venous Thromboembolism". Blood 124, nr 21 (6.12.2014): 4829. http://dx.doi.org/10.1182/blood.v124.21.4829.4829.
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Abstract Determining the death rate due to venous thromboembolism (VTE) among cancer patients is a daunting task, suffering from methodological constraints associated with death certificates, administrative data bases, surveillance methods and disease recognition. While it is clear that VTE is a clinical marker of a high risk of dying from cancer and that cancer patients are at relatively higher risk of dying from pulmonary embolism (PE), there are large variations in mortality directly attributable to VTE. To examine mortality from venous thromboembolism (VTE) associated with cancer, we reviewed the medical records of patients from the University of Texas MD Anderson Cancer Center (UTMDACC) suffering from cancer plus VTE who died during the time period 3/1/2000 and 10/31/2010. A list of all cancer patients at UTMDACC who died during the time period 3/1/2000 through 10/31/2010 and carried one of 18 ICD-9 coded diagnoses of VTE (encompassing deep venous thrombosis, pulmonary embolism, inferior vena cava thrombosis and renal vein thrombosis) was provided by the institutional Enterprise Information Warehouse. Among 99,288 patients who died at MD Anderson over the ~ 10 year period, 11,032 had a diagnosis of VTE. The electronic health records (EHR) of 9,000 of these patients were reviewed to determine if death was attributed to VTE. A cause-of-death could be assigned to 1,459 patients and could not be determined for the remaining 7,541. The distribution of malignancies among patients with a defined cause-of-death was 19.8 % - acute leukemia or myelodysplastic syndrome (8.3% with acute myelogenous leukemia); 14.2% - lymphoma; 12.5% - genitourinary; 12.5% - lung; 12.4% - gastrointestinal; 7.3% - breast; 4.4% - myeloma; and 17% - other. The attributed cause-of-death for these 1,459 patients was disease progression in 52.8%; infection in 19.7%; VTE in 13.9%; respiratory failure (not due to disease progression or PE) in 7.6%; arterial thrombosis (myocardial infarction, sudden death, stroke or congestive heart failure) in 3.5%; hemorrhage in 1.2%; and other (stem cell transplant-related multiorgan failure, graft-versus-host disease, liver failure, diffuse alveolar hemorrhage, thrombotic microangiopathy, hepatic veno-occlusive disease, fall, or suicide) in the remaining 1.3%. Among the 203 patients whose cause-of-death was attributed to VTE, 51 had hematological malignancies (16 acute leukemia, 15 lymphoma, 14 myelodysplastic syndrome or a myeloproliferative neoplasm, 6 myeloma) and 152 were solid tumor patients (39 lung, 34 genitourinary, 26 gastrointestinal, 15 breast, and 37 miscellaneous [melanoma, sarcomas, germ cell and others]). 162 out of 203 patients with death attributed to VTE were receiving anticoagulation and 40 were treated with an inferior vena caval filter. 109/203 had thrombocytopenia (platelet count < 150,000/μl), 81 of whom received anticoagulation. 6/81 of the thrombocytopenic patients who died of VTE had bleeding; 3 of these patients had WHO grade 4 bleeding contributing to death. Fatal VTE was documented by objective measures in 83.3% (169 out of 203) and by clinical measures in 16.7% (34 out of 203). Assuming that all clinical diagnoses were wrong, objectively documented VTE directly caused 11.6% of the deaths (169/1459). These results indicate that VTE is a major cause of death among patients with heterogeneous malignancies and suggest that improved treatment of malignancy-associated VTE will have an immediate and significant favorable impact on the survival of cancer patients. Better data are needed to determine the therapeutic index of prophylactic and therapeutic anticoagulation in cancer patients, particularly those considered to be at high risk for bleeding. Disclosures Kroll: Boerhinger-Ingelheim: Membership on an entity's Board of Directors or advisory committees; Aplagon Therapeutics: Membership on an entity's Board of Directors or advisory committees.
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Singh, Ashutosh Kumar, i Safal Dhungel. "Pattern of Impacted Mandibular Third Molar in Patients Presenting to Tertiary Care Hospital in Chitwan, Nepal". Orthodontic Journal of Nepal 9, nr 2 (31.12.2019): 38–42. http://dx.doi.org/10.3126/ojn.v9i2.28412.
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Introduction: Impacted third molars are a major cause of visit to the oral surgeon and are associated with various complications like pain, inflammation of associated soft tissue and trismus leading to a need for their surgical removal. They are widely classified on the basis of angulation, depth and position as evident from orthopantomogram however they present in a diverse panorama of patterns each presenting different level of difficulty and different techniques for their removal. Our study describes different pattern of impacted lower third molars and perform brief literature review of dental and skeletal implications of impacted third molars.
Materials & Method: A retrospective study was designed in which 401 orthopantomogram were examined and the sex of patient, side of impaction and winters angulation based classification, depth and position classification as given by Pell and Gregory were recorded. Descriptive data analysis was performed with SPSS version 24 software.
Result: Out of total number of impactions 191(47.6%) were in females and 210(52.4%) were in males. Right sided impaction was seen in 199(49.6%) cases and 202(50.4%) were seen on left side. Mesioangular impaction was most common 203(50.6%) followed by distoangular 97(24.2%), horizontal 51(12.7%) and vertical 17(4.2%). Most common depth level of impaction was level I with 203(50.6%) followed by level II 178(44.4%) and level III 20(5%). Most common position was position B 355(88.5%) followed by position A 43(10.7%) and position C 3(0.7%). The most common pattern was IB (n=170) and IIB (n=166).
Conclusion: The most common impaction is mesioangular followed by distoangular and horizontal. Most of the impacted third molars are in moderately difficult position.
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Kuang, Lu, Wei-Hong Wei, Xiao-Yan Sang, Yang Pan i Cheng Song. "Synthesis and characterization of new poly(diketone imide)s derived from 1,4-bis(3,4-dicarboxybenzoyl)benzene dianhydride and various diamines". High Performance Polymers 32, nr 9 (15.06.2020): 1043–51. http://dx.doi.org/10.1177/0954008320930798.
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1,4-Bis(3,4-dicarboxybenzoyl)benzene dianhydride, an aromatic bis(ketone anhydride) monomer, was synthesized by the Friedel–Crafts reaction of terephthaloyl dichloride and o-xylene, followed by the oxidation of the intermediate tetramethylated compound and cyclodehydration of the resulting tetraacid. A series of new poly(diketone imide)s (PDKIs) were prepared from this dianhydride with various aromatic diamines via a conventional two-stage process that included ring-opening polyaddition to form the poly(amic acid)s followed by thermal or chemical imidization. Most of the PDKIs through chemical imidization were soluble in aprotic amide solvents, such as N, N-dimethylacetamide, N-methyl-2-pyrrolidone, m-cresol, and so on. The resulting PDKIs had good thermal property with the glass transition temperature of 203–275°C, the temperature at 5% weight loss of 500–539°C, and the residue of 51–60% at 800°C in nitrogen. Additionally, strong and flexible PDKI films obtained by thermal imidization exhibited outstanding mechanical property with the tensile strength of 88.8–158.5 MPa, tensile modulus of 1.9–3.5 GPa, and elongation at breakage of 7–21%.
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de Boer, A., C. Kluft, J. M. Kroon, F. J. Kasper, H. C. Schoemaker, J. Pruis, D. D. Breimer, P. A. Soons, Jef J. Emeis i Adam F. Cohen. "Liver Blood Flow as a Major Determinant of the Clearance of Recombinant Human Tissue-Type Plasminogen Activator". Thrombosis and Haemostasis 67, nr 01 (1992): 083–87. http://dx.doi.org/10.1055/s-0038-1648385.
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SummaryThe influence of changes in liver blood flow on the clearance of rt-PA was studied both in healthy subjects and in a perfused rat liver model. Liver blood flow in healthy subjects was documented indirectly by the clearance of indocyanine green (ICG). Exercise reduced liver blood flow on average by 57% with a 95% confidence interval (95% Cl) ranging from 51% to 62% (n = 5) and increased plasma levels of rt-PA activity (after an i. v. infusion of 18 mg of rt-PA over 120 min) by 119% (95% Cl, 58% - 203%) and rt-PA antigen by 91% (95% Cl, 30% - 140%). In the perfused rat liver model it was shown that halving or doubling of the physiological flow rate of a perfusate, containing rt-PA caused a proportional change in the clearance of rt-PA, while the extraction of rt-PA by the liver remained similar. In conclusion, liver blood flow is a major determinant of the clearance of rt-PA. This may have important implications for dosage of rt-PA in patients with myocardial infarction.
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Johnson, B. Delia, Kathleen M. Dwyer, Frank Z. Stanczyk, Vera Bittner, Sarah L. Berga, Glenn D. Braunstein, Ricardo Azziz, YuChing Yang, Georgina E. Hale i C. Noel Bairey Merz. "The Relationship of Menopausal Status and Rapid Menopausal Transition with Carotid Intima-Media Thickness Progression in Women: A Report from the Los Angeles Atherosclerosis Study". Journal of Clinical Endocrinology & Metabolism 95, nr 9 (1.09.2010): 4432–40. http://dx.doi.org/10.1210/jc.2010-0126.
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Context: The onset of menopause has been associated with an increase in cardiovascular risk factors. However, little information is available about the rapidity of the menopausal transition and its relationship to the development of preclinical cardiovascular disease (CVD). Objective: Our objective was to assess whether the rate of carotid intima-media thickness (cIMT) progression over time differs according to 1) menopausal status and 2) rapidity of the menopausal transition. Design: We evaluated 203 community-based women aged 45–60 yr without previously diagnosed CVD who underwent three repeated measurements of cIMT as a measure of preclinical CVD over 3 yr. Menopausal status was ascertained at each visit based on menstrual cycle parameters and reproductive hormone profiles. Of these, 21 remained premenopausal, 51 transitioned, and 131 were postmenopausal throughout the observation period. Results: Age-adjusted cIMT progression rates were similar among premenopausal, transitioning, and postmenopausal women. In the 51 transitioning women, age was not related to rate of cIMT progression. However, the rapidity of menopausal transition was related to cIMT progression: women transitioning from pre- to postmenopause within the 3-yr period had a higher rate of cIMT progression compared with women with a slower transition. Statistical adjustments for the significant covariates of systolic blood pressure, body mass index, race, cigarette smoking, or hormone therapy use did not alter the findings. Conclusions: Among healthy women undergoing repeated cIMT measurement, a more rapid menopausal transition was associated with a higher rate of preclinical CVD progression measured by cIMT. Further work is needed to explore potential mechanisms of this effect.
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Pearce, Rahul, Lisa Eyler, Tyler Bell, Jeremy Elman, Christine Fennema-Notestine, Donald Hagler, Carol Franz i William Kremen. "C-REACTIVE PROTEIN AND BRAIN MORPHOLOGY". Innovation in Aging 6, Supplement_1 (1.11.2022): 447. http://dx.doi.org/10.1093/geroni/igac059.1748.
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Abstract The process by which aging leads to increased risk for Alzheimer’s disease and dementia is not entirely understood, but one hypothesized contributor is the occurrence of low-grade inflammation in older age. In this study, we examined how peripheral levels of C-reactive protein (CRP), a measure of systemic inflammation, relate to brain structure and diffusion in a group of older adult men. After excluding twenty-seven participants for confounding medical conditions, we analyzed a final sample of 426 community-dwelling men from the Vietnam Era Twin Study of Aging, who were assessed at average age 68 for plasma levels of CRP and underwent structural and diffusion brain imaging. Linear mixed models adjusting for family relatedness, age, medical morbidity, and BMI examined associations of CRP with whole brain volume, whole gray and white matter volumes, global fractional anisotropy (FA), and global mean diffusivity (MD). Higher CRP was related to lower whole brain volume (β = -.13, p = .006), including lower whole white matter volume (β = -.22, p <.001) but not whole gray matter volume (p = .08). Higher CRP was related to lower global FA (β = -.51, p = .012) but not global MD (p = .203). Regionally, a relationship of higher CRP to lower FA was found in the anterior thalamic radiation (β = -.51, p = .010), which is implicated in a variety of higher order cognitive processes. These results suggest a link between peripheral inflammation and lower white matter integrity in older adult men, the implications of which for cognitive aging and dementia should be further explored.
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Corradi, Ezia Maria, Camila Aparecida Araújo, Jussara Do Rocio Machado i Mário Humberto Esteves. "Caracterização de hipertensos de unidade de saúde em Curitiba, Paraná". Revista de Enfermagem UFPE on line 2, nr 3 (29.06.2008): 270. http://dx.doi.org/10.5205/reuol.348-11415-1-le.0203200809.
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ABSTRACTThe aim of this descriptive-exploratory study is characterize the reasons of abandonment of the hypertensive patients by the Hypertensive Patients Program from a Health Unit at Curitiba city, State of the Paraná, Brazil. The users of low risk, totalizing 203 ones, of which, 44 had been selected those residents at micron-areas around. Domiciliary visit was carried through, which 13 users had been located. In this occasion the collection of data instrument was applied to identify to the current conditions of health and the reasons of the abandonment of the Program. Data had been organized and analyzed based on descriptive statistic and argued with endorsement of literature. The results showed the age between 51 and 60 years (69%); 61.5% with alteration of the blood pression in the 1, 2 and 3 of risk; 77% in medication use. Amongst the reasons of absence of the program 14% it affirmed not to have time, 14% for feeling themselves well, 21% had complaints in the attendance and, or not trusting the Program. The 84,6% of the inactives has the controlled hypertension, but with risks to the health; they has unfamiliarity about the illness, its gravity, forms to coexist it and as to carry through the necessary control. Descriptors: hypertension; community health centers; nursing.RESUMOEstudo descritivo-exploratório com o objetivo de caracterizar os motivos de abandono de portadores de hipertensão arterial ao Programa de Hipertensão Arterial de uma Unidade de Saúde de Curitiba, Paraná, Brasil. Participaram 203 usuários de risco baixo, dos quais, foram selecionados aqueles residentes em micro-áreas de abrangência, correspondendo a 44. Foi realizada visita domiciliar, com a qual foram localizados 13 usuários. Nessa ocasião foi aplicado o instrumento de coleta de dados para identificar condições atuais de saúde e motivos do abandono ao Programa. Os dados foram organizados e analisados com base na estatística descritiva e discutidos com respaldo da literatura. Os resultados mostraram a faixa etária entre 51 e 60 anos (69%); 61,5% com alteração da PA entre os estágios 1, 2 e 3 de risco; 77% em uso de medicação. Dentre os motivos de afastamento do programa 14% afirmaram não ter tempo, 14% por sentir-se bem, 21% com queixas no atendimento e, ou não confiarem no Programa. Concluí-se que 84.6% dos inativos apresentam hipertensão controlada, mas com risco de conseqüências à saúde; há desconhecimento acerca do que é a doença, sua gravidade, formas de conviver com ela e como realizar o controle necessário. Descritores: hipertensão; unidade básica de saúde; enfermagem.RESUMEN El objetivo de este estudio descriptivo-exploratorio es caracterizar las razones de abandono de los pacientes hipertensos de un Programa de Pacientes Hipertensos de uma Unidad de Salud en la ciudad de Curitiba, Estado de Paraná, Brasil. Los usuarios de bajo riesgo totalizando 203, de los cuales, 44 habían sido seleccionados en torno a las áreas vizinhas. Visita domiciliaria se llevó a cabo que localizaron 13 usuarios. En esta ocasión, la recopilación de instrumento de datos se aplicó a identificar a las actuales condiciones de salud y las razones del abandono del Programa. Los datos han sido organizados y analizados descriptivo de la forma y argumentó con el aval de la literatura. Los resultados mostraron la edad entre los 51 y los 60 años (69%); 61,5% con alteración de la presión sanguínea en el 1, 2 y 3 de riesgo, 77% en el uso de fármacos. Entre las razones de ausencia del programa el 14% afirmó no disponer de tiempo, el 14% para sentirse bien, un 21% en las denuncias y la asistencia, o no confiar en el Programa. El 84,6% de los inactivos se ha controlado la hipertensión, pero con riesgos para la salud, sino que ha desconocimiento sobre la enfermedad, su gravedad, las formas de coexistir y, como para llevar a cabo el control necesario. Los resultados demostraron la edad entre 51 y 60 años (el 69%); 61.5% con la alteración de la presión arterial en el 1, los 2 y los 3 del riesgo; el 77% en uso de medicación. Entre las razones de la ausencia del programa el 14% afirmó no tener tiempo, 14% no tener síntomas de hipertensión, 21% tenían quejas en la atención y, o confiando en el programa. El 84.6% de los inactives tiene la hipertensión controlada, pero con riesgos a la salud; tienen poco saber sobre la enfermedad, su gravedad, formas a coexistir él y el control necesario. Descriptores: hipertensión; centros de salud; enfermería.
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Mohanan, Neethu, i S. Thanuskodi. "Open access information as a platform for sustainable development". Linguistics and Culture Review 5, S3 (19.11.2021): 1258–75. http://dx.doi.org/10.21744/lingcure.v5ns3.1814.
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Open Access (OA) literature is digital, online, free of charge, and free of most copyright and licensing restrictions, what makes it possible are the internet and the consent of the author or copyright holder. In most fields, scholarly journals do not pay authors, who can, therefore, consent to OA without losing revenue. In this respect, scholars and scientists are very differently situated from most musicians and movie-makers, and controversies about open access to music and movies do not carry over to research literature. Open access is entirely compatible with peer review, and all the major open access initiatives for scientific and scholarly literature insist on its importance, just as authors of journal articles donate their labor, journal editors, and referees participating in peer review. The study shows that out of 456 respondents considered for the study 203 [44.5%] belongs to Arts, 169 [37.1%] belong to Science, 33 [7.2%] Education and 51 [11.2%] belongs to Management. The findings of the study also show that out of 456 respondents considered for the study among which 81 [17.8%] belong to the M. Phil program, 102 [22.4%] belong to Ph.D. Program and 273 [59.9%] are faculty members.
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Sadat-Ali, Mir, Moaad Alfaraidy, Abdulaziz AlHawas, Ahmed Abdallah Al-Othman, Dakheel A. Al-Dakheel i Badar K. Tayara. "Morbidity and mortality after fragility hip fracture in a Saudi Arabian population: Report from a single center". Journal of International Medical Research 45, nr 3 (8.05.2017): 1175–80. http://dx.doi.org/10.1177/0300060517706283.
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Objective To determine the functional morbidity and mortality after fragility hip fracture and compare the mortality with three other common diseases. Methods Data were collected from patients admitted to King Fahd Hospital of the University, AlKhobar from January 2010 to December 2014. Demographic data included the preoperative American Society of Anesthesiologists (ASA) score as assessed by the anesthetist and the type of surgery. Personal and telephone interviews were performed, and data were entered into a database and analyzed. Results We identified 203 patients with fragility proximal femoral fractures, and the data of 189 patients (109 male, 80 female; average age, 66.90 ± 13.43 years) were available for analysis. The overall mortality rate was 26.98% (51 patients). The mortality rate was significantly higher among patients with an ASA score of 4 (36.36%) than 1 (20.45%). With respect to morbidity, only 48.23% of patients were able to return to their pre-fracture status; 32.35% of those who required assisted walking and 83.4% of those who required a wheelchair became bedridden. Conclusions Our data demonstrate that patients with fragility hip fractures have high morbidity and a mortality rate approaching 30%. Age and the ASA score significantly influence this high mortality rate.
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Franco-Paredes, Karina, Felipe Díaz-Reséndiza, Felipe Santoyo-Telles i Carlos A. Hidalgo-Rasmussena. "Conductas y actitudes alimentarias anómalas y calidad de vida relacionada con la salud en niños". Revista de Psicología 26, nr 2 (22.12.2017): 1. http://dx.doi.org/10.5354/0719-0581.2017.47947.
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El propósito de esta investigación fue identificar la presencia de conductas y actitudes alimentarias anómalas (CAAA) y su asociación con el peso corporal y la calidad de vida relacionada con la salud en una muestra infantil. Participaron 398 niños de una escuela pública y tres privadas, 203 mujeres (51%) y 195 varones (49%), quienes contestaron el Test Infantil de Actitudes Alimentarias (ChEAT-26) y el Cuestionario de Calidad de Vida Pediátrica (PedsQL); también se registró su peso y talla para el cálculo del índice de masa corporal. Se encontró que la prevalencia de CAAA fue de 14,1% para la escuela pública y 13,4% para la escuela privada. Los participantes con sobrepeso presentaron mayor riesgo de CAAA (OR: 2,36; 95% IC: 1,18-4,73) en comparación con los participantes de peso normal. Las niñas y niños con CAAA que asistían a escuelas públicas presentaron puntuaciones significativamente menores en funcionamiento físico, funcionamiento escolar y el total del PedsQL que sus contrapartes de escuelas privadas. El tipo de escuela, la edad y las CAAA explicaron el funcionamiento escolar. Se concluyó que una cantidad importante de niños, principalmente con sobrepeso, presentaron CAAA y estas influyen en la calidad de vida relacionada con la salud.
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Prakoso, Bayu Budi, Suroto Suroto, Arif Bulqini i Benny Widya Priadana. "IDENTIFIKASI POLA MAKAN, INDEKS MASSA TUBUH, DAN AKTIVITAS FISIK MAHASISWA PROGRAM MATAKULIAH PENDIDIKAN JASMANI DAN KEBUGARAN". Jurnal Pendidikan Olahraga 10, nr 1 (28.07.2021): 43–56. http://dx.doi.org/10.31571/jpo.v10i1.2092.
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Kondisi kesehatan dewasa ini sering dihubungkan dengan pola makan, indeks massa tubuh (IMT), dan aktivitas fisik. Kondisi ketiga variabel tersebut diharapkan dapat menjadi tolok ukur pola hidup sehat yang sedang dijalani oleh seseorang. Sebagai matakuliah pengembangan kepribadian, matakuliah pendidikan jasmani dan kebugaran memiliki beberapa misi yang salah satunya adalah memberikan pengalaman kepada mahasiswa dalam menerapkan pola hidup sehat. Untuk itu, tujuan artikel ini adalah sebagai langkah awal mengetahui kondisi pola makan, IMT, dan aktivitas fisik sebagai need-assessment dalam merumuskan treatment dalam proses perkuliahan. Metode penelitian yang digunakan adalah cross-sectional study memanfaatkan survei online menggunakan google form yang terbimbing saat pelaksanaan perkuliahan. Sebanyak 254 (51 laki-laki dan 203 perempuan) dari 267 responden layak digunakan dalam penelitian ini. Analisis data menggunakan deskriptif statistik dan persentase. Hasil penelitian menunjukkan bahwa asupan gizi mahasiswa cenderung cukup dan frekuensi makan mahasiswa wajar, komposisi tubuh mahasiswa berdasarkan IMT mayoritas ideal, aktivitas fisik mahasiswa belum cukup ditinjau dari frekuensi dan waktu, instensitas aktivitas fisik tergolong cukup. Untuk itu, treatment dalam proses perkuliahan direkomendasikan untuk memacu aktivitas fisik mahasiswa agar memenuhi rekomendasi WHO atau hasil-hasil penelitian yang relevan.
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Bedoya, Julio. "Evolución de la Gammagrafía en el Servicio de Medicina Nuclear de la Facultad de Medicina de la Universidad Nacional Mayor de San Marcos y del Hospital Obrero de Lima". Anales de la Facultad de Medicina 49, nr 4 (9.04.2014): 659. http://dx.doi.org/10.15381/anales.v49i4.5605.
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1. El trabajo estudia la evolución, de la Gammagrafía o Scanning, en el Servicio de Medicina Nuclear de la Facultad de Medicina y del Hospital Obrero de Lima, para lo que se señalan, 3 etapas: A. La primera, comprende; desde la primera captación de iodo radioactivo, realizada en Agosto de 1955, hasta la delimitación manual de la tiroides, pasando por la realización de todas las pruebas líquidas realizadas con un detector de centelleo de cristal de pozo; se considera ésta etapa, como un estudio y entrenamiento previo indispensable, para poder trabajar, en forma eficiente, con los equipos e isótopos usados actualmente para realizar gammagrafías. B. La segunda etapa, comprende la utilización de un scanner de cristal de 2 pulgadas, de uno de los primeros diseñados, que permitió realizar scanning de tiroides, diferenciando los nódulos, en hiper, norma e hipocaptadores, y también realizar scanning de hígado con Rosa de Bengala 131, de Bazo, con glóbulos rojos calentados y marcados con cromo 51, y de riñones con He 203. C. La tercera etapa, relata el uso de un mejor isotopo de vida corta el Tc 99., que permite acumular una mayor dosis en el órgano y obtener una mejor imagen, con el mismo equipo de diseño primitivo, con que se había trabajado hasta esa entonces. Se obtuvo gammagrafías de tiroides, de cerebro, de hígado, y de bazo con Te 99., y también gammagrafías de pulmones, con microagregados de albúmina 131. 2. Se presentan casos, de pacientes preparados con Hq 203, para obtener gammagrafías de cerebro, y en los cuales, no se pudo obtener imagen con el equipo de cristal de 2 pulgadas, pero colocados los mismos pacientes de inmediato, en aparatos de mejores características, fue posible obtener buenas imágenes. 3. Con esto, se demuestra la necesidad urgente; A. De adquirir, equipos modernos de alta sensibilidad. B. De disponer de los nuevos isótopos. C. De instalar, una pequeña sección de Radioquímica, condiciones indispensable, para obtener de éste importantísimo método toda la ayuda que puede brindar en Biología y Medicina.
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Hasanzade, Sabir, Yunus Emre Ergin, Murat Gevrek, Naim Boran Tumer, Hayrettin Levent Mavioglu i Hakki Zafer Iscan. "Early and midterm outcomes of thoracic endovascular aortic repair with Lifetech Ankura™ thoracic endograft: A single tertiary center experience". Turkish Journal of Vascular Surgery 32, nr 2 (2023): 60–65. http://dx.doi.org/10.9739/tjvs.2023.02.05.
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Aim: Thoracic aortic pathologies describe a wide spectrum of potentially life-threatening diseases almost always in a comorbid aged patient cohort. Thoracic endovascular aortic repair (TEVAR) is a less invasive treatment choice, offering reduced mortality and morbidity compared to open surgery. We decided to reveal our experience over safety and efficacy data with Lifetech Ankura™ Thoracic endografts with early and midterm outcomes, retrospectivelytiology. Material and Methods: Between January 2018 and January 2023, for a 5-year period, 203 patients who experienced TEVAR procedure with Lifetech Ankura™ Thoracic endograft were retrospectively evaluated. For the patients who required revascularization of the vessel branches originating from the aortic segments, all types of assistive techniques were performed. Intentional coverage of Left subclavian artery was also performed mostly in urgent patients. Results: 251 endografts were implanted in 203 patients. The most frequent aortic pathologies were the thoracic aortic fusiform aneurysm (56.6%) and type B aortic dissection (25.6%), respectively. Early (30-day/in-hospital) mortality occurred in 9 patients in total (4.4%). Technical success rate was 100%, and there was no conversion to open surgery. No other major adverse event, including cerebral, cardiac, or renal complication requiring dialysis, was observed. The average intensive care unit time was 16.9±11 hours (2-160), length of stay was 5.1±3.2 days. CSF drainage was performed in 51 patients inserted before the procedure prophylactically (25.1%). All patients who survived the operation were followed for 18.6±9.3 months. In the follow up period, four patients needed extension for endoleaks and two additive petticoat procedures were performed. One patient who had TEVAR due to a malperfused type B aortic dissection in the acute phase experienced RTAD 2 weeks after the initial procedure. Conclusion: TEVAR with LifeTech Ankura™ Thoracic Stent Graft system provides a safe, effective, and durable treatment with successful early outcomes and technical success. Wide spectrum in length and non-identical radiopaque proximal markers seem to facilitate some advanced endovascular skills. Long-term durability of the endograft should be tested.
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González, Aurelio. "Ana María Freire López, Poesía popular durante la Guerra de la Independencia española, 1808-1814. Grant & Cutler, London, 1993; 203 pp. (Research Bibliographies and Checklists, 51)." Nueva Revista de Filología Hispánica (NRFH) 42, nr 1 (1.01.1994): 242–43. http://dx.doi.org/10.24201/nrfh.v42i1.1846.
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A, Fajreldines. "Reduction of drug-drug interaction and inappropriate prescription in polymedicated elderly who consult in the ambulatory". International Physical Medicine & Rehabilitation Journal 6, nr 4 (10.12.2021): 86–88. http://dx.doi.org/10.15406/ipmrj.2021.06.00289.
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Introduction: Older adults or elderly people over 64 years of age are patients more vulnerable to suffering adverse events related to medication, and this can generate states of both physical and psychological discomfort, loss of autonomy, mental disorders, etc. Objectives: To analyze the drug-drug interaction and inappropriate prescription of drugs in the outpatient setting in the elderly and implement barriers to reduce this problem. Materials and methods: Quasi-experimental study, of the before after type. The Beers 2019 criteria were used to assess inappropriate drug prescribing. The Uptodate definition of drug-drug interactions and their classification were used. Results: 203 polypathological, sarcopenic elderly patients were studied. These patients attended the outpatient consultation during the 2016-2018 period. 99 patients participated in the pre-intervention and 104 in the post-intervention. The distribution by sex was: 110 (54.2%) women and 93 (45.8%) men. The mean age was 77.3 + 13.3 years. In the total sample analyzed before the intervention, 33 (33.3%) showed inappropriate prescription of drugs criteria. Drug interactions in the pre-intervention were present in 51 patients (51.5%). After the intervention that consisted of training doctors with the Beers criteria and editing a list with clinically relevant interactions in the elderly, which can cause adverse events, inappropriate prescription was reduced to 26 patients (25%), p = 0.05, and clinically relevant interactions were reduced from 51 (51.51%) to 12 (11.53%), p = 0.003. The association between inappropriate prescription and clinically relevant interactions is OR: 3.23 (95% CI 1.91-3.88). Conclusions: The proportion of patients with inappropriate prescription is within the ranges published by various authors as well as drug interactions, the intervention was good to reduce the two problems in this sample of patients.
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Reni, M., P. Passoni, M. G. Panucci, R. Nicoletti, L. Galli, G. Balzano, A. Zerbi, V. Di Carlo i E. Villa. "Definitive Results of a Phase II Trial of Cisplatin, Epirubicin, Continuous-Infusion Fluorouracil, and Gemcitabine in Stage IV Pancreatic Adenocarcinoma". Journal of Clinical Oncology 19, nr 10 (15.05.2001): 2679–86. http://dx.doi.org/10.1200/jco.2001.19.10.2679.
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PURPOSE: To evaluate the efficacy and toxicity of a cisplatin, epirubicin, gemcitabine, and fluorouracil (PEF-G) schedule on stage IV pancreatic adenocarcinoma. PATIENTS AND METHODS: Patients ≤ 70 years, with no prior chemotherapy and with bidimensionally measurable stage IV pancreatic adenocarcinoma, Eastern Cooperative Oncology Group performance status ≤ 2, and adequate bone marrow, kidney, and liver function were eligible for this trial. Eligibility criteria for clinical benefit assessment were pain with at least a daily analgesic consumption of two nonsteroidal anti-inflammatory drugs or Karnofsky performance status between 50 and 70. Treatment consisted of 40 mg/m2 each of cisplatin and epirubicin day 1, gemcitabine 600 mg/m2 on days 1 and 8 every 4 weeks, and fluorouracil 200 mg/m2/d as a protracted venous infusion. RESULTS: Between April 1997 and April 1999, 49 patients from a single institution were eligible for the study. Altogether, 203 cycles (median, four cycles) of PEF-G were delivered. The objective response rate was 58% in 43 assessable patients and 51% in the intent-to-treat population. Fourteen patients had stable disease. Grade 3 or 4 World Health Organization neutropenia occurred in 51% of cycles, thrombocytopenia in 28%, anemia in 7%, stomatitis in 5%, and diarrhea, and nausea, and vomiting in 2%. The median duration of response was 8.5 months. The median time to tumor progression was 7.5 months. The median survival was 11 months in the assessable population and 10 months in the intent-to-treat population. Clinical benefit was achieved in 22 (78%) of 28 assessable patients. CONCLUSION: PEF-G is a well-tolerated and safe regimen; it obtained a very high rate of durable responses and deserves further evaluation in a phase III trial.