Artykuły w czasopismach na temat „2016 h-310”

This short note proposes a new interpretation of the epitaph of Ama Helenê Ioudaia, an inscription recently published by L. H. Blumell in jsj 47 (2016): 310-29, on the basis of a different reading of some of the Greek words in this inscription.

En la evolución humana encontramos dos procesos: el proceso de hominización y el proceso de humanización (Jordana 1988, pág. 97) (Polo, 2016, pág. 9). El primero se refiere a los cambios morfológicos que culminan en el H sapiens y el segundo se refiere a los logros culturales conseguidos. Hasta fines del siglo pasado se pensaba que los logros culturales de tipos de homínidos como los Australopitecos, los H. habilis y H. erectus obedecían al conocimiento sensorial, en concreto a la operación cognoscitiva de la imaginación la cual no requiere de la abstracción para pensar de modo sensorial. Solo se reconocía el pensamiento intelectual en el H. sapiens incluyendo el H. sapiens arcaico por el pensamiento simbólico que reflejan obras y comportamientos tales como el arte rupestre y el enterramiento de muertos asociados con ellos. El conocimiento sensorial se refiere a la asociación imaginativa y al uso del razonamiento condicional más rudimentario: si A entonces B (Polo, 2016, pág. 17). Sin embargo los descubrimientos en arqueología experimental de las dos últimas décadas reclaman el conocimiento abstracto para la fabricación de herramientas más antiguas de hace 3.3 millones de años (Byrne, 2018, en imprenta) (Harman et al, 2015, pág. 310). ¿Qué validez filosófica tienen esos avances arqueológicos? ¿Cómo se integran dichos avances en la antropología transcendental de Polo? El presente artículo es una breve respuesta a estas preguntas.

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310 Background: In Phase III studies, ipilimumab did not extend OS in unselected populations with metastatic castration-resistant prostate cancer (mCRPC) (Kwon, 2014; Beer, 2014), suggesting that successful cancer immunotherapy development strategies require the evaluation of treatment effects in biomarker-driven segments. In addition, PTEN loss has been identified as a potential mechanism of resistance to immunotherapy (Peng, 2016). Therefore, we explored possible associations between cancer immunity (CI)-related biomarkers and PTEN loss in mCRPC samples. Methods: Tumor samples obtained in the Phase II study of AA ± Ipat in patients with mCRPC (de Bono, ESMO 2016) were retrospectively profiled. DNA alterations and tumor mutational burden (TMB) were assessed by FoundationOne. RNA-seq analysis of multiple CI-related expression signatures was performed. Tumor-immune lymphocyte (TIL) scores were analyzed in 3 compartments (stromal, sTIL; intratumoral, iTIL; peritumoral, pTIL) based on H&E stained specimens. Up to 10 evenly distributed fields were examined; the average of these fields was used to estimate the %TILs for each compartment. Results: Strong associations were observed between multiple CI-related signatures (e.g., INFγ-induced, immune checkpoints, Treg, checkpoint inhibitors). Fewer than 10% of the samples had a high level (≥ 10% of the tumor area) of TIL infiltration in any compartment (Table). TIL scores, TMB values, PTEN status and Gleason score all appeared to be independently associated, and none were associated with CI-related gene signatures, except for a possible association between pTILs and the B-cell signature (ρ = 0.49, P < 0.0001). Conclusions: Comprehensive high-content profiling of prostate cancer samples suggests that PTEN status and CI-related biomarkers were independently associated, while TMB and TIL values were generally not associated with CI-related signatures. Clinical trial information: NCT01485861. [Table: see text]

In this work, we investigate subluminal and superluminal light propagation in a vee-type three-level atomic medium under an external magnetic field. The dispersion and absorption behaviors are studied for the cases of absence and presence of a magnetic field. It is found that under an electromagnetically induced transparency condition, the light pulse can be switched between subluminal and superluminal propagation by ON-OFF switching of the magnetic field. Finally, the transient response of the medium is discussed, which shows that the considered scheme has potential applications in magneto-optic switching devices. Full Text: PDF ReferencesBoller K J, Imamoglu A, Harris S E, "Observation of electromagnetically induced transparency", Phys. Rev. Lett. 66 (1991) 2593. CrossRef Fleischhauer M, Imamoglu A, Marangos J P, "Electromagnetically induced transparency: Optics in coherent media", Rev. Mod. Phys. 77 (2005) 633. CrossRef L.V. Hau, S. E. Harris, Z. Dutton, C.H. Bejroozi, "Light speed reduction to 17 metres per second in an ultracold atomic gas", Nature, 397 (1999) 594. CrossRef Z. Dutton, N.G.C. Slowe, L.V. Hau, "The art of taming light: ultra-slow and stopped light", Europhysics News, 35 (2004) 33. CrossRef V. Bharti, V. Natarajan, "Sub- and super-luminal light propagation using a Rydberg state", Opt. Commun. 392 (2017) 180-184. CrossRef Khoa D X, Doai L V, Son D H and Bang N H, "Enhancement of self-Kerr nonlinearity via electromagnetically induced transparency in a five-level cascade system: an analytical approach", J. Opt. Soc. Am. B. 31 (2014) 1330. CrossRef Hamedi H R, Gharamaleki A H, and Sahrai M, "Colossal Kerr nonlinearity based on electromagnetically induced transparency in a five-level double-ladder atomic system", Appl. Opt 22 (2016) 5892. CrossRef A. Fountoulakis, A.F. Terzis, E. Paspalakis, "All-optical modulation based on electromagnetically induced transparency", Phys. Lett. A 374, (2010) 3354. CrossRef Khoa D X, Doai L V, Mai Anh L. N, Trung L. C, Thuan P. V, Dung N. T, and Bang N. H, J. "Optical bistability in a five-level cascade EIT medium: an analytical approach", Opt. Soc. Am. B, 33 (2016) 735. CrossRef Hoang Minh Dong, and Nguyen Huy Bang, "Controllable optical switching in a closed-loop three-level lambda system", Phy. Scr. 94, (2019) 115510. CrossRef Dong H M, Doai L V, Sau V N, Khoa D X and Bang N H, "Propagation of a laser pulse in a three-level cascade atomic medium under conditions of electromagnetically induced transparency", Photonics Letter of Poland, 3 (2016) 73. CrossRef Khoa D X, Dong H M, Doai L V and Bang N H, "Propagation of laser pulse in a three-level cascade inhomogeneously broadened medium under electromagnetically induced transparency conditions", Optik 131 (2017) 497. CrossRef H. M. Dong, L.V. Doai, and N.H. Bang, "Pulse propagation in an atomic medium under spontaneously generated coherence, incoherent pumping, and relative laser phase", Opt. Commun. 426 (2018) 553-557. CrossRef Jiahua Li, Rong Yu, Liugang Si, and Xiaoxue Yang, "Propagation of twin light pulses under magneto-optical switching operations in a four-level inverted-Y atomic medium", J. Phys. B: At. Mol. Opt. Phys. 43 (2010) 065502. CrossRef S. H. Asadpour, H. R. Soleimani, "Polarization dependence of optical bistability in the presence of external magnetic field", Opt. Commun 310 (2014) 120-124. CrossRef H.M. Dong, L.T.Y. Nga, and N.H. Bang, "Optical switching and bistability in a degenerated two-level atomic medium under an external magnetic field", App. Opt. 58, (2019) 4192. CrossRef H. M. Dong, L. T. Y. Nga, D. X. Khoa, N. H. Bang, "Controllable ultraslow optical solitons in a degenerated two-level atomic medium under EIT assisted by a magnetic field", Sci. Rep. 10 (2020) 15298. CrossRef Daniel A. Steck, "Rubidium 87D Line Data," http://steck.us/alkalidata. CrossRef

ABSTRACT The nearby galaxy NGC 300 is hosting two luminous transient supersoft X-ray sources with bolometric luminosities above 3 × 1038 erg s−1, assuming simple blackbody spectra with temperatures around 60–70 eV. For one of these, SSS1, a periodic modulation of 5.4 h was observed in an XMM–Newton observation from 2001 January 1 lasting 47 ks, but not visible six days earlier when the luminosity was higher. We report here the detection of a new outburst from this source, which occurred during two more recent XMM–Newton observations performed on 2016 December 17–20 lasting for 310 ks. The luminosity was similar as in 2000 December, and the 0.2–2.0 keV light curve revealed again a periodic modulation, with a period of 4.68 ± 0.26 h, significant only in the first of the two observations. Taking into account the large uncertainties (the 2001 period was re-estimated at 5.7 ± 1.1 h), the two values could be marginally compatible, and maybe associated with an orbital period, although the signal strength is highly variable. Due to the new long exposures, an additional absorption feature is now visible in the spectra, which we modelled with an absorption edge. This component decreases the bolometric luminosity below 3 × 1038 erg s−1 and would therefore allow the presence of a white dwarf with a mass close to the Chandrasekhar limit. The system was found in outburst in 1992, 2000, 2008, and 2016 suggesting a possible recurrence period of about eight years. We discuss viable models involving white dwarfs, neutron stars, or black holes.

ABSTRACT: This study aims to examine the effect of health, education, and labor force moderated by urban population on the Human Development Index. This study uses a quantitative approach and a Moderated Regression Analysis technique with a sample of 25 OIC countries from 2010-2019 taken by purposive sampling method. The results showed that health, education, and the labor force affected the Human Development Index. While the urban population moderates the effect of health and the workforce on the Human Development Index, the urban population does not moderate the effect of education on the Human Development Index. This study has a novelty in the results of the study, namely the basic education variable which has a significant but negative effect on the Human Development Index. This research is limited to a sample of OIC member countries because more than 30% of poor countries with low income according to World Bank data are in OIC member countries, so it is hoped that this research will be able to provide references related to increasing the human development index to save them from poverty. Keywords: Education, Health, Human Development Index, Labor Force, Urban Population ABSTRAK: Penelitian ini bertujuan untuk menguji pengaruh kesehatan, pendidikan, dan angkatan kerja yang dimoderasi oleh kepadatan populasi terhadap Human Development Index. Penelitian ini menggunakan pendekatan kuantitatif dan teknik Moderated Regression Analysis dengan sampel 25 negara OKI dari tahun 2010-2019 yang diambil dengan metode purposive sampling. Hasil penelitian menunjukkan kesehatan dan angkatan kerja berpengaruh positif signifikan terhadap Human Development Index, namun pendidikan berpengaruh negatif signifikan terhadap Human Development Index. Urban population memoderasi pengaruh antara kesehatan dan angkatan kerja terhadap Human Development Index, namun urban population tidak memoderasi pengaruh pendidikan terhadap Human Development Index. Penelitian ini memiliki kebaruan dalam hasil penelitian, yaitu variabel pendidikan dasar yang justru berpengaruh namun negatif signifikan terhadap Human Development Index. Penelitian ini terbatas dilakukan pada sampel negara anggota OKI sebab lebih dari 30% negara miskin dengan pendapatan rendah menurut Data Bank Dunia adalah ada pada negara anggota OKI, sehingga diharapkan penelitian ini mampu memberikan referensi terkait peningkatan indeks pembangunan manusia untuk menyelamatkannya dari kemiskinan. Kata Kunci: Angkatan Kerja, Human Development Index, Kesehatan, Pendidikan, Urban Population. DAFTAR PUSTAKA Adom, K., & Asare-Yeboa, I. T. (2016). An evaluation of human capital theory and female entrepreneurship in sub-Sahara Africa: Some evidence from Ghana. 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The people who live in the Merapi area have been going on for years. Merapi is the most active volcano in Central Java that can threaten the community, but the community still exists today, of course, having local wisdom in responding to the eruption of Merapi. This study aims to determine the local wisdom of Wonolelo Village before, during, and after the Merapi eruption. In addition, to find out the historical relationship of the Merapi eruption to local wisdom and the challenges faced by Wonolelo Village in maintaining the sustainability of local wisdom. This research was used as a descriptive qualitative method. The method of collecting data is done through observation, in-depth interviews, and documentation. Data sources of this study are community leaders, spiritual leaders, and people who are more than 70 years old. Analysis of the data used is sourced triangulation based on the Miles & Huberman model. The results showed that local wisdom in responding to the Merapi eruption in Wonolelo Village still exists today. Local wisdom is divided into three segments, namely before, during, and after the eruption of Merapi. Local wisdom before the Merapi eruption is a notification that Merapi eruption activity will occur. Local wisdom in Wonolelo Village has challenges in the form of modernization and not running the local wisdom relay to young people. Keywords: Disaster, Local wisdom, Merapi volcano. References Andreastuti, S.D., Newhall, C., Dwiyanto, J. (2006). Menelusuri Kebenaran Letusan Gunung Merapi 1006. Jurnal Geologi Indonesia, Vol. 1, No. 4, Hal. 201-207. Andreastuti, S., Paripurno, E., Gunawan, H., Budianto, A., Syahbana, D., & Pallister, J. (2019). Character of community response to volcanic crises at sinabung and kelud volcanoes. Journal of Volcanology and Geothermal Research, 382, 298-310. doi:10.1016/j.jvolgeores.2017.01.022 Atmojo, S. E., Rusilowati, A., Dwiningrum, S. I. 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Перспективным источником биофлавоноидов являются плоды облепихи крушиновидной(ОК) (Hippophae rhamnoides L.). Согласно литературным данным, в плодах выявлено наличие такихфлавоноидов, как кверцетин, кемпферол, гесперидин, рутин, гиперозид, изорамнетин, мирицетин,цитрин, катехин и другие. В настоящее время стандартизация данного растительного сырья проводится по содержанию каротиноидов, в то время как классу полифенольных соединений уделено недостаточное внимание. В связи с вышесказанным целью настоящей работы являлось исследованиесостава различных групп флавоноидов плодов ОК различных сортов методом тонкослойной хроматографии (ТСХ). Экспериментально подобраны и теоретически обоснованы оптимальные условия для хроматографического разделения зон флавоноидов плодов ОК. Впервые получен и частично идентифицирован ТСХ-профиль флавоноидов плодов 10 различных изученных сортов вида ОК. Наибольшее количество зон флавоноидов наблюдается у сорта «Рябиновая» (13 зон), наименьшее - у сортов «Столичная» и «Трофимовская» (по 10 зон), из которых идентифицированы рутин и кверцетин. Выявлены зоны, присутствующие на хроматограммах всех изучаемых сортов, а, следовательно, они могут характеризоваться, как зоны-маркеры вида. Установлено наличие или отсутствие уникальных зон-маркеров исследованных сортов ОК («Рябиновая», «Ботаническая ароматная», «Столичная», «Трофимовская», «Нивелена» и «Ботаническая»). ТСХ-профиль флавоноидов плодов ОК позволяет предположительно провести идентификацию сорта методом «отпечатков пальцев». ЛИТЕРАТУРА 1. Тараховский Ю.С. и др. Флавоноиды: биохимия, биофизика, медицина. Пущино:Sуnchrobook, 2013, 310 c.2. Тринеева О.В., Перова И.Б., Сливкин А.И., Эллер К.И. // Сорбционные и хроматографические процессы. 2017. Т. 17. № 1. С. 87-93.3. Тринеева О.В. Автореферат дис. доктора фармацевтических наук. М. 2017. 48 с.4. Mendelova A. et al. // Potravinarstvo Slovak Journal of Food Sciences. 2016. Vol. 10. No 1. pp. 59-64.5. Suryakumar G., Gupta A. // Journal of ethnopharmacology. 2011. Vol. 138(2). pp. 268-278.6. Wang J. et al. // Journal of the science of food and agriculture. 2011. Vol. 91(8). pp. 1446-1451.7. Singh B., Peter K. // New Age Herbals. 2018.pp. 29-54.8. Скалий Л.П. Облепиха: Пособие для садоводов-любителей. М. Ниола-Пресс. ЮНИОН-паблик. 2007. 240 с.9. Yang, B., Kallio H. // Trends in Food Science Technology. 2002. Vol. 13. No 5. pp. 160-167.10. Rafalska A., Abramowicz K., Krauze M. // World scientific news. 2017. Vol. 72. pp. 123-140.11.Тринеева О.В. Комплексное исследование содержания и специфического профилябиологически активных веществ плодов облепихи крушиновидной: монография. Воронеж: Издательский дом ВГУ. 2016. 224 с.12.Тринеева О.В., Сафонова И.И., Сафонова Е.Ф., Сливкин А.И. // Химико-фармацевтический журнал. 2014. Т. 48. № 2. С. 48-52.13.Тринеева О.В., Сафонова И.И., Сафонова Е.Ф., Сливкин А.И. // Сорбционные и хроматографические процессы. 2012. Т. 12. № 5. С. 806-813.14. Рудаков О.Б., Востров И.А., Федоров С.В. и др. Спутник хроматографиста. Методы жидкостной хроматографии. Воронеж. «Водолей». 2004. 528 с.15. Кирхнер Ю. Тонкослойная хроматография. М. «Мир». 1981. С. 402-407.16. Гейсс Ф. Основы тонкослойной хроматографии. М. «Мир». 1999. 405 с.17.Государственная фармакопея Российской Федерации XIV изд. Режим доступа:http://femb.ru/femb/pharmacopea.php (дата обращения 15.08.2019).

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Background: Despite in techniques advancement to patient care for respiratory tracts are instrumented may complicate the IAP course up to 50% in patients with mechanical ventilation. It requires rapid diagnoses and treatment that is appropriate as per patient condition. Many studies revealed negative impact with delayed administration and antibiotic treatment in IAP patients may increase the hospital mortality and morbidity. The primary objective of the study was to estimate the incidence of IAP in the patient admitted in ICU of tertiary care hospitals in Rawalpindi Pakistan. Study Design: Observational cross sectional study. Setting: ICU units of various tertiary care hospitals in Rawalpindi, Pakistan. Period: One year from Dec 2016-Dec 2017. Materials and Methods: A total 450 subjects were enlisted for the study; these patients were selected randomly. The exclusion criteria include all patients with Acute Respiratory Distress Syndrome (ARDS) or those on long-term antibiotic or steroid therapy and all the pregnant women whereas all the patients of both sexes, kept on ventilator for more than 48 h and above the age of 18 years were included in this study. Results: We enrolled a total of 450 patients for this study. The average age of all the participants was 61.51 + 12.8 with range 36-91. 230(51.1%) of the patients were male whereas 220(48.9%) were females. The Trauma-Pulm contusion was absent in all patients. In ICU 150 (33.3%) were diagnosed with COPD, 150(33.3%) with Asthma, 220(48.9%) with ARDS, 10 (2.2%) with head trauma and 310 (68.8%) with diabetes.200 (44.4%) smokers, 40(8.8%) were having lung cancer, 310(68.8%) were hypertensive and 20 (4.4%) were with Pneumothorax - requiring Chest Tube. Conclusion: We may conclude from our study that ICU associated Pneumonia is a serious issue, that developed with longer hospital stay, duration of mechanical ventilation and re-intubation. By reducing the mechanical ventilation duration, pneumonia can be controlled.

Problem solving skills are very important in supporting social development. Children with problem solving skills can build healthy relationships with their friends, understand the emotions of those around them, and see events with other people's perspectives. The purpose of this study was to determine the implementation of playing unplugged coding programs in improving early childhood problem solving skills. This study used a classroom action research design, using the Kemmis and Taggart cycle models. The subjects of this study were children aged 5-6 years in Shafa Marwah Kindergarten. Research can achieve the target results of increasing children's problem-solving abilities after going through two cycles. In the first cycle, the child's initial problem-solving skills was 67.5% and in the second cycle it increased to 80.5%. The initial skills of children's problem-solving increases because children tend to be enthusiastic and excited about the various play activities prepared by the teacher. The stimulation and motivation of the teacher enables children to find solutions to problems faced when carrying out play activities. So, it can be concluded that learning unplugged coding is an activity that can attract children's interest and become a solution to bring up children's initial problem-solving abilities. Keywords: Early Childhood, Unplugged Coding, Problem solving skills References: Akyol-Altun, C. (2018). Algorithm and coding education in pre-school teaching program integration the efectiveness of problem-solving skills in students. Angeli, C., Smith, J., Zagami, J., Cox, M., Webb, M., Fluck, A., & Voogt, J. (2016). A K-6 Computational Thinking Curriculum Framework: Implications for Teacher Knowledge. Educational Technology & Society, 12. Anlıak, Ş., & Dinçer, Ç. (2005). 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Abstract To determine effects of cow BCS and calving season on calf vigor and size and the relationship of calf size with vigor, 310 multiparous and primiparous beef cows (age: 4.6 ± 2.2 yr; BW: 663 ± 86 kg; BCS: 5.3 ± 0.6) from 3 spring (2015, 2016, 2017) and 4 fall (2015, 2017, 2018, 2019) calving seasons were observed during parturition. Time to stand (n = 191) was determined as minutes from birth to standing successfully for 5 sec. Within 24 h, calf BW (n = 187) and size [shoulder to tailhead length (STL), heart girth (HG), and abdominal girth (AG; n = 154)] were recorded. Data were analyzed using a mixed model containing effects of calving season (spring and fall), BCS category (&lt; 5, =5, ≥6), and their interaction. Correlations were determined between time to stand and calf measurements separately for spring (n = 79) versus fall (n = 111). Cows with BCS &lt; 5 gave birth to lighter (P = 0.02) calves that tended to have a faster (P ≤ 0.13) time to stand than =5 and ≥6. Calves from cows with BCS ≥6 tended to have greater (P ≤ 0.09) STL than =5 and &lt; 5. Calves from cows with BCS &lt; 5 had smaller (P = 0.13) HG than =5. Fall-born calves tended to have smaller (P ≤ 0.06) BW, HG, and AG than spring-born calves. Within fall calves, there tended to be a positive relationship (r = 0.16; P = 0.09) between time to stand and calf BW. Despite this, spring calves had a negative relationship (r = -0.26; P = 0.02) between time to stand and calf BW. In conclusion, cow BCS and calving season affect calf size and may affect calf vigor. These data suggest that calving season may dictate the relationship between calf vigor and size.

Abstract. Soil moisture is highly variable in space and time, and deficits (i.e., droughts) play an important role in modulating crop yields. Limited hydroclimate and yield data, however, hamper drought impact monitoring and assessment at the farm field scale. This study demonstrates the potential of using field-scale soil moisture simulations to support high-resolution agricultural yield prediction and drought monitoring at the smallholder farm field scale. We present a multiscale modeling approach that combines HydroBlocks – a physically based hyper-resolution land surface model (LSM) – with machine learning. We used HydroBlocks to simulate root zone soil moisture and soil temperature in Zambia at 3 h 30 m resolution. These simulations, along with remotely sensed vegetation indices, meteorological data, and descriptors of the physical landscape (related to topography, land cover, and soils) were combined with district-level maize data to train a random forest (RF) model to predict maize yields at district and field scales (250 m). Our model predicted yields with an average testing coefficient of determination (R2) of 0.57 and mean absolute error (MAE) of 310 kg ha−1 using year-based cross-validation. Our predicted maize losses due to the 2015–2016 El Niño drought agreed well with losses reported by the Food and Agriculture Organization (FAO). Our results reveal that soil moisture is the strongest and most reliable predictor of maize yield, driving its spatial and temporal variability. Soil moisture was also a more effective indicator of drought impacts on crops than precipitation, soil and air temperatures, and remotely sensed normalized difference vegetation index (NDVI)-based drought indices. This study demonstrates how field-scale modeling can help bridge the spatial-scale gap between drought monitoring and agricultural impacts.

The industrial development era 4.0, many threats lurk children in the form of bad influence through books, videos, or other media and become a challenge for parents and teachers. Gender education and the introduction of personal identity are important given early on. This study aims to determine the effect of teacher knowledge on the implementation of gender education in early childhood. This research uses quantitative survey research methods with a simple linear regression design for data analysis. The respondents were 34 early childhood education teachers. The results show the data with the conclusion that the calculated value> t table and p-value (sig) of 0.001 (<0.05) which means that there is a significant influence on teacher knowledge about early childhood gender education. Research suggests about how to improve gender education in early childhood education and create learning modules for early childhood teacher guidance. Keywords: Early gender education, Teacher knowledge about gender education References: Adoniou, M. (2015). Teacher knowledge: a complex tapestry. Asia-Pacific Journal of Teacher Education, 43(2), 99–116. https://doi.org/10.1080/1359866X.2014.932330 Awaji M, A. K. (2016). Analysis of workrelated injuries among health care workers in armed forces hospi-tal southern region, kingdom of saudi arabia. Br J Med Med Res., 15(4). Azwar, S. (2010). Sikap Manusia: Teori dan Pengukurannya Edisi 2. Yogyakarta: Pustaka Pelajar. Chapman, R. (2016). A case study of gendered play in preschools: how early childhood educators’ perceptions of gender influence children’s play. Early Child Development and Care, 186(8), 1271–1284. https://doi.org/10.1080/03004430.2015.1089435 Cherney, I. D., & Dempsey, J. (2010). Young children’s classification, stereotyping and play behaviour for gender neutral and ambiguous toys. Educational Psychology, 30(6), 651–669. https://doi.org/10.1080/01443410.2010.498416 Filipović, K. (2018). Gender Representation in Children’s Books: Case of an Early Childhood Setting. Journal of Research in Childhood Education, 32(3), 310–325. https://doi.org/10.1080/02568543.2018.1464086 Francis, B. (2010). Gender, toys and learning. Oxford Review of Education, 36(3), 325–344. https://doi.org/10.1080/03054981003732278 Frödén, S. (2019). Situated decoding of gender in a Swedish preschool practice. Ethnography and Education, 14(2), 121–135. https://doi.org/10.1080/17457823.2017.1422135 Ghozali, I. (2011). Aplikasi Analisis Mulivariante dengan Program IBM SPSS 19 Edisi 5. Semarang: Badan Penerbit Universitas Diponegoro. Huggins, V. (2014). Education 3-13 : International Journal of Primary , Elementary and Early Years Education Children at play : Learning gender in the early years. gray2011.p(November). https://doi.org/10.1080/03004279.2011.644316 La Paro, K. M., Van Schagen, A., King, E., & Lippard, C. (2018). A Systems Perspective on Practicum Experiences in Early Childhood Teacher Education: Focus on Interprofessional Relationships. Early Childhood Education Journal, 46(4), 365–375. https://doi.org/10.1007/s10643-017-0872-8 Lynch, M. (2015). Guys and dolls: a qualitative study of teachers’ views of gendered play in kindergarten. Early Child Development and Care, 185(5), 679–693. https://doi.org/10.1080/03004430.2014.950260 Meland, A. T., & Kaltvedt, E. H. (2019). Tracking gender in kindergarten. Early Child Development and Care, 189(1), 94–103. https://doi.org/10.1080/03004430.2017.1302945 Muasya, J., & Kazungu, T. (2018). ‘The unfinished business’: Exploring teachers’ views on gender and pedagogical practices in public preschools in Nairobi county, Kenya. African Educational Research Journal, 6(1), 10–19. https://doi.org/10.30918/aerj.61.18.007 Notoatmodjo, S. (2014). Ilmu Perilaku Kesehatan. Jakarta: Rineka Cipta. Nursalam. (2014). Manajemen Keperawatan: Aplikasi Dalam Praktik Keperawatan Profesional. Jakarta: Salemba Medika. Papalia, D. E., & Duskin, R. (2015). Perkembangan Manusia. Jakarta: Salemba Humanika. Salawati, L., Herry, N., & Putra, A. (2014). Analisis Tindakan Keselamatan Dan Kesehatan Kerja Perawat Dalam Pengendalian Infeksi Nosokomial Di Ruang ICU RSUD DR. Zainoel Abidin Banda Aceh. 14(3). Solehudin, M. (2018). Peran Guru Pai Dalam Mengembangkan Kecerdasan Emosional (EQ) Dan Kecer-dasan Spiritual (SQ) Siswa Smk Komputama Majenang. Jurnal Tawadhu, 1(3). Sulastri, S., & Ahmad Tarmizi, A. T. (2017). Peran Orang Tua Dalam Pendidikan Anak Usia Dini. Raudhatul Athfal: Jurnal Pendidikan Islam Anak Usia Dini, 1(1), 61–80. https://doi.org/10.19109/ra.v1i1.1526 Suyadi. (2014). Teori pembelajaran anak usia dini, dalam kajian neourons. Bandung: PT Remaja Rosdakarya. Vanner, C. (2019). Examining gender safety in schools: Teacher agency and resistance in two primary schools in kirinyaga, kenya. Education Sciences, 9(1). https://doi.org/10.3390/educsci9010063 Warin, J., & Adriany, V. (2017). Gender flexible pedagogy in early childhood education. Journal of Gender Studies, 26(4), 375–386. https://doi.org/10.1080/09589236.2015.1105738 Wingrave, M. (2018). Perceptions of gender in early years. Gender and Education, 30(5), 587–606. https://doi.org/10.1080/09540253.2016.1258457 Wu, Y. P., Wu, J. F., Chen, Y. M., Han, L., Han, P. G., Wang, P., & Gao, F. (2015). Shyness and School Adjustment Among Chinese Preschool Children: Examining the Moderating Effect of Gender and Teacher–Child Relationship. Early Education and Development, 26(2), 149–166. https://doi.org/10.1080/10409289.2015.970503 Zhukovskyi, V., & Kostiuk, O. (2015). Stages Of Gender Education In Canadian Secondary Schools. Comparative Professional Pedagogy, 5(2), 31–38. https://doi.org/10.1515/rpp-2015-0037

2533 Background: Many cancer clinical trials (CT) lack appropriate representation of specific patients populations, limiting the generalizability of the evidence obtained. Therefore, we determined the representation of ethnic minorities in oncology CT. Methods: Enrollment data from all therapeutic trials reported as completed in clinicaltrial.gov from 2003 to 2016 were analyzed. CT in rare cancers (< 1% incidence) or with recruitment outside of the US were excluded. Enrollment fraction (EF) was defined as the number of enrollees divided by the 2013 SEER database cancer prevalence. Chi-square test was used to estimate differences in categorical data. Results: Out of 1,012 CT, 310 (31%) reported ethnicity with a total of 55689 enrollees. Distribution by race and comparison with data from 1996-2002, US cancer prevalence and US census are described in the Table. Participation in CT varied significantly across ethnic groups, non-Hispanic Whites (NHW) were more likely to be enrolled in CT (EF of 1.2%) than African Americans (EF of 0.7%, p < 0.001) and Hispanics (EF of 0.4%, p<0.001). A decrease in African Americans (AA) and Hispanics (H) enrollment was observed when compared with historical data from 1996 to 2002. Hispanics were less represented in breast and prostate cancer CT contributing only to 3% and 1.5% of the study population; African Americans were less represented in lung (5.4%) and renal cell carcinoma (3%) trials. Asians were well represented and their recruitment doubled over the past 14 years (2% vs 5.3%). Conclusions: African Americans and Hispanics were less likely to be enrolled in CT. Comparing with historical data; we observed a decrease in minorities’ recruitment in the past 14 years. This change could be attributed to the increased complexity of CT and mandatory molecular testing as many minorities lack access to institutions with genetic testing capacity. Future trials should take extra measures to recruit participants that adequately represent the U.S. cancer population. [Table: see text]

Plants for medicinal purposes are considered as the main source of health care for the majority of the world population. In order to promote medicinal plants in Algeria, the present work aimed to assess the physico-chemical characterization, hemolytic, and antioxidant activities of Ammodaucus leucotrichus essential oil of an endemic plant from south-west of Algeria. The plant was harvested from the region of Bechar (south-west of Algeria). The oil was obtained by hydrodistillation method using Clevenger apparatus. The antioxidant activity of the oil was carried out using DPPH scavenging assay, and its effect on erythrocyte cells was evaluated by measuring the hemolytic degree. The obtained results showed that this oil presented a low antioxidant activity compared to positive control (ascorbic acid). The hemolytic activity was very low since the oil diluted to 1/10, while it was low in the pure state. 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The effects of biochar and biochar combined with N-fertilizer on the content of soil organic matter in water-stable aggregates were investigated. A field experiment was conducted with different biochar application rates: B0 control (0 t ha-1), B10 (10 t ha-1) and B20 (20 t ha-1) and 0 (no N), 1st and 2nd levels of nitrogen fertilization on silt loam Haplic Luvisol (Dolna Malanta, Slovakia), in 2014. The N doses of level 1 were calculated on required average crop production using balance method. Level 2 included additional 100% of N in year 2014 and additional 50% of N in year 2016. The effects were investigated during the growing seasons of spring barley and spring wheat in 2014 and 2016, respectively. Results indicate that the B20N2 treatment significantly increased the proportion of water-stable macro-aggregates (WSAma) and reduced water-stable micro-aggregates (WSAmi). Aggregate stability increased only in the B20N1 treatment. The B20N2 treatment showed a robust decrease by 27% in the WSAma of 0.5-0.25 mm. On the other hand, an increase by 56% was observed in the content of WSAma with fractions 3-2 mm compared to the B0N0 treatment. The effect of N fertilizer on WSAma was confirmed only in the case of the B10N2 treatment. The proportion of WSAma with fractions 3-2 mm decreased by 42%, while the size fraction of 0.5-0.25 mm increased by 30% compared to the B10N0 treatment. The content of WSAma with fractions 1-0.5 mm decreased with time. On the contrary, the content of WSAma with particle sizes above 5 mm increased with time in all treatments except the B10N2 and B20N2 treatments. A statistically significant trend was identified in the proportion of WSA in the B10N2 and B20N2 treatments, which indicates that biochar with higher application levels of N fertilizer stabilizes the proportion of water-stable aggregates. 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Ключові слова: пам’ять, ідентичність, національна ідентичність, комеморація, кмеморативні практики. Анотація Національна ідентичність, з одного боку, є однією з фундаментальних ідентичностей, тобто, вона може служити орієнтиром для людини навіть тоді, коли інші (професійні, родинні, класові) швидко змінюються внаслідок трансформації суспільства. З іншого боку, зміни суспільства, його соціальних інститутів (як агентів впливу) змінюють зміст і форми національної ідентичності членів суспільства. Відтак усталення тієї чи іншої моделі ідентичності здійснюється в певному соціальному контексті, який задає не тільки спектр альтернатив, але й набір різних комеморативних практик. У статті обґрунтовується взаємообумовленість смислоконституювання пам’яттєвого та ідентичнісного дискурсів, із урахуванням того, що пам’яттєвий дискурс, з одного боку, віддзеркалює характерні риси національної ідентичності, а з іншого – формує своєрідну смислову основу останньої, моделює її, впливаючи на зміни з різним ступенем інтенсивності. Доведено, що національна ідентичність формується за допомогою колективної пам’яті та комеморативних практик. Посилання Anderson, 2001 – Anderson B. Voobrazhaemыe soobshchestva. Razmыshlenyia ob ystokakh y rasprostranenyy natsyonalyzma [Imaginary communities. Reflections on the origins and spread of nationalism]. M. : Kanon-press, 2001. 288 s. [in Russian] Assman, 2012 – Assman A. Prostory spohadu. Formy ta transformatsii kulturnoi pam’iati [Spaces of memory . Forms and transformations of cultural memory] / per. z nim. K. Dmytrenko, L. Doronicheva, O. Yudin. K.: Nika-Tsentr, 2012. 440 s. (Seriia «Zmina paradyhmy». Vyp. 15). 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ABSTRAK Kemisikinan merupakan suatu permasalahan yang harus ditemukan cara mengentaskannya. Islam agama yang sempurna telah memberikan solusi melalui instrument zakat, infak, dan sedekah. Tujuan dari penelitian ini adalah untuk menilai dampak zakat, infak, sedekah di LAZNAS LMI (Lembaga Manajemen Infaq) dengan Pendekatan CIBEST. Metode penelitian yang digunakan adalah kuantitatif dengan uji beda antara kondisi material dan spiritual mustahik sebelum dibantu dengan setelah disalurkan dana ZIS. Hasil analisis dari 355 penerima manfaat menunjukkan bahwa pada kuadran I, penerima manfaat yang dikategorikan sejahtera bertambah 28% sesudah dibantu. Pada kuadran II, penerima manfaat yang dikategorikan miskin secara material menurun sebesar 27,7%. Selain itu pada kuadran IV penerima manfaat yang dikategorikan miskin secara absolut, juga ikut menurun sebesar 0,3%. Hasil Uji Beda juga menunjukan ada perbedaan indeks spiritual maupun indeks material penerima manfaat antar sebelum dan sesudah pemberian dana ZIS dibuktikan dengan Uji Beda Wilcoxon untuk indeks material value, dan Uji T berpasangan untuk indeks spiritual value.. Dengan adanya hasil penilaian kaji dampak ini diharapkan dampak dari bantuan yang diberikan bisa terukur dan juga menjadi bahan evaluasi serta perencanaan untuk program-program yang akan datang. Implikasi temuan penelitian ini dapat memberikan refrensi terkait manfaat zakat, infak, sedekah dalam membantu mengetaskan kemiskinan yang dilakukan oleh lembaga amil zakat nasional. Secara praktik, Lembaga Manajemen Infaq perlu memberikan perhatian khusus kepada mustahik yang berada di kategori miskin absolut, dengan memberikan intervensi ekonomi dan pembinaan secara spiritual. Kata Kunci: Kaji Dampak, ZIS, Kemiskinan, CIBEST, Lemabga Amil Zakat, Lembaga Manajemen Infaq. ABSTRACT Poverty is a problem that must find a way to eradicate. Islam, the perfect religion, has provided a solution through the instruments of zakat, infaq, and shadaqah. The purpose of this study was to assess the impact of Zakat, Sedekah, and Infaq in Lembaga Manajemen Infaq with the CIBEST Approach. The method used is quantitative by distributing questionnaires and testing the difference between the material and spiritual conditions of the mustahik before being assisted with after the ZIS funds are distributed. The results of the analysis of 355 beneficiaries showed that in quadrant I, beneficiaries categorized as prosperous increased by 28% after being assisted. In quadrant II, beneficiaries categorized as materially poor decreased by 27.7%. In addition, in quadrant IV, beneficiaries who are categorized as absolute poor also decreased by 0.3%. The results of the Difference Test also show that there are differences in the spiritual index and material index of beneficiaries between before and after the provision of ZIS funds, as evidenced by the Wilcoxon Difference Test for the material value index, and the paired T-test for the spiritual value index. The assistance provided can be measured and can also be used as material for evaluation and planning for future programs. The implications of the findings of this study can provide a reference regarding the benefits of zakat, shadaqah, and infaq in helping to alleviate poverty carried out by the national amil zakat institution. In practice, Amil Zakat Organization needs to pay special attention to mustahik who are in the absolute poor category, by providing economic intervention and spiritual guidance. Keywords: Assessment of Impact, ZIS, Poverty, CIBEST, Amil Zakat Organization, Lembaga Manajemen Infaq. DAFTAR PUSTAKA Ahmed, B. O., Johari, F., & Wahab, K. A. (2017). 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ABSTRAK Kemisikinan merupakan suatu permasalahan yang harus ditemukan cara mengentaskannya. Islam agama yang sempurna telah memberikan solusi melalui instrument zakat, infak, dan sedekah. Tujuan dari penelitian ini adalah untuk menilai dampak zakat, infak, sedekah di LAZNAS LMI (Lembaga Manajemen Infaq) dengan Pendekatan CIBEST. Metode penelitian yang digunakan adalah kuantitatif dengan uji beda antara kondisi material dan spiritual mustahik sebelum dibantu dengan setelah disalurkan dana ZIS. Hasil analisis dari 355 penerima manfaat menunjukkan bahwa pada kuadran I, penerima manfaat yang dikategorikan sejahtera bertambah 28% sesudah dibantu. Pada kuadran II, penerima manfaat yang dikategorikan miskin secara material menurun sebesar 27,7%. Selain itu pada kuadran IV penerima manfaat yang dikategorikan miskin secara absolut, juga ikut menurun sebesar 0,3%. Hasil Uji Beda juga menunjukan ada perbedaan indeks spiritual maupun indeks material penerima manfaat antar sebelum dan sesudah pemberian dana ZIS dibuktikan dengan Uji Beda Wilcoxon untuk indeks material value, dan Uji T berpasangan untuk indeks spiritual value.. Dengan adanya hasil penilaian kaji dampak ini diharapkan dampak dari bantuan yang diberikan bisa terukur dan juga menjadi bahan evaluasi serta perencanaan untuk program-program yang akan datang. Implikasi temuan penelitian ini dapat memberikan refrensi terkait manfaat zakat, infak, sedekah dalam membantu mengetaskan kemiskinan yang dilakukan oleh lembaga amil zakat nasional. Secara praktik, Lembaga Manajemen Infaq perlu memberikan perhatian khusus kepada mustahik yang berada di kategori miskin absolut, dengan memberikan intervensi ekonomi dan pembinaan secara spiritual. Kata Kunci: Kaji Dampak, ZIS, Kemiskinan, CIBEST, Lemabga Amil Zakat, Lembaga Manajemen Infaq. ABSTRACT Poverty is a problem that must find a way to eradicate. Islam, the perfect religion, has provided a solution through the instruments of zakat, infaq, and shadaqah. The purpose of this study was to assess the impact of Zakat, Sedekah, and Infaq in Lembaga Manajemen Infaq with the CIBEST Approach. The method used is quantitative by distributing questionnaires and testing the difference between the material and spiritual conditions of the mustahik before being assisted with after the ZIS funds are distributed. The results of the analysis of 355 beneficiaries showed that in quadrant I, beneficiaries categorized as prosperous increased by 28% after being assisted. In quadrant II, beneficiaries categorized as materially poor decreased by 27.7%. In addition, in quadrant IV, beneficiaries who are categorized as absolute poor also decreased by 0.3%. The results of the Difference Test also show that there are differences in the spiritual index and material index of beneficiaries between before and after the provision of ZIS funds, as evidenced by the Wilcoxon Difference Test for the material value index, and the paired T-test for the spiritual value index. The assistance provided can be measured and can also be used as material for evaluation and planning for future programs. The implications of the findings of this study can provide a reference regarding the benefits of zakat, shadaqah, and infaq in helping to alleviate poverty carried out by the national amil zakat institution. In practice, Amil Zakat Organization needs to pay special attention to mustahik who are in the absolute poor category, by providing economic intervention and spiritual guidance. Keywords: Assessment of Impact, ZIS, Poverty, CIBEST, Amil Zakat Organization, Lembaga Manajemen Infaq. DAFTAR PUSTAKA Ahmed, B. O., Johari, F., & Wahab, K. A. (2017). 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The rapid development of technology makes it easier for mothers to provide stimulation related to growth and development using gadgets. However, parental knowledge is needed about the safe limits of using a gadget in early childhood. This study aims to determine the perspective and behavior of mothers about the use of gadgets in toddlers. The method used is quantitative research with a cross-sectional approach. The participants of this study were thirty-one mothers who have early childhood and who are empowering family welfare. The inclusion criteria were mothers who agreed to be respondents, the exclusion criteria for mothers who did not have gadgets. This study uses a questionnaire measurement instrument for data collection. Data analysis was performed univariate and bivariate using the chi-square test. 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ABSTRACT Islamic banking is undoubtedly faced with several potential financing risks, with the three largest financing contracts (Mudharaba, Musharaka, and Murabaha) that reduce the financial performance of Islamic banks. The potential risk is strengthened if the stability of national economic growth is contracted. Therefore, this research aims to investigate the impact of Mudharaba, Musharaka, and Murabaha financing on Financing Risk moderated by the business cycle and the relationship between Financing Risk and the Financial Performance of Islamic Commercial Banks. The sample of this study was 12 Islamic Commercial Banks in Indonesia during the period 2017-2021. The Data were then analyzed using the technique of Moderated Regression Analysis (MRA). Researchers found that Musharaka financing has a significant positive effect on Financing Risk, Mudharaba and Murabaha Financing has an insignificant effect on Financing Risk, and Financing Risk has a significant negative effect on Financial Performance. The Business Cycle does not moderate the Financing of Mudharaba, Musharakah, and Murabaha on Financing Risk. The results can encourage the Islamic Commercial Bank to evaluate the distribution strategy of Musharaka financing, optimize the distribution of Mudharaba and Murabaha financing, and prepare financing strategies that do not depend on macroeconomic conditions. Keywords: Financing Risk, Financing, Business Cycle, Financial Performance. ABSTRAK Perbankan syariah dengan tiga akad pembiayaan terbesar (Mudharaba, Musharaka, dan Murabaha) dihadapkan pada sejumlah potensi risiko pembiayaan yang menurunkan kinerja keuangan Bank Syariah. Potensi risiko tersebut menguat jika stabilitas pertumbuhan ekonomi nasional juga terganggu atau mengalami kontraksi. Oleh karena itu, penelitian ini hendak mengkaji pengaruh Pembiayaan Mudharaba, Musharaka, dan Murabaha terhadap Risiko Pembayaran dengan dimoderasi oleh Siklus Bisnis, dan sekaligus menguji hubungan antara Risiko Pembayaran dan Kinerja Keuangan Bank Syariah. Sampel penelitian ini adalah 12 Islamic Commercial Bank di Indonesia selama periode 2017-2021. Data tersebut kemudian dianalisis dengan menggunakan teknik Moderated Regression Analysis (MRA). Peneliti menemukan bahwa Pembiayaan Musharaka berpengaruh positif signifikan terhadap Risiko Pembiayaan, Pembiayaan Mudharaba dan Murabaha tidak berpengaruh signifikan terhadap Risiko Pembiayaan, dan Risiko Pembiayaan berpengaruh negatif signifikan terhadap Kinerja Keuangan. Adapun Siklus Bisnis tidak dapat memoderasi Pembiayaan Mudharaba, Musharaka, dan Murabaha terhadap Risiko Pembiayaan. Hasil penelitian ini dapat menjadi evaluasi bagi Islamic Commercial Bank agar dapat mengevaluasi strategi penyaluran pembiayaan Musharaka, mengoptimalkan penyaluran pembiayaan Mudharaba dan Murabaha, dan mempersiapkan strategi pembiayaan yang tidak bergantung pada kondisi makro ekonomi. Kata Kunci: Risiko Pembiayaan, Pembiayaan, Siklus Bisnis, Kinerja Keuangan. REFERENCES Abdillah, W., & Hartono, J. (2015). Partial least square (PLS) alternatif structural equation modelling (SEM) dalam penelitian bisnis. CV. Andi Offset. Abdul-rahman, A., & Nor, S. M. (2016). Challenges of profit-and-loss sharing financing in Malaysian Islamic banking. Malaysian Journal of Society and Space 12, 2(2), 39–46. Adzimatinur, F., & Manalu, V. G. (2020). The impact of mudharabah and musharakah based financing to credit risk. 1st Annual Conference of Ihtifaz: Islamic Economics, Finance, and Banking, 127–134. Aiyubbi, D. E., Widarjono, A., & Amir, N. (2022). 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Language skills are significant predictors of early academic and social-emotional outcomes of children and are important predictors of school readiness. This study aims to improve children's language skills through the application of mind mapping learning methods. This classroom action research used Kemmis and Taggart's cycle model. The research subjects were 12 children in group B consisting of eight boys and four girls. The data was collected through observation, interviews, and documentation with the validity of the data using source triangulation and method triangulation. This research uses data analysis techniques in the form of data condensation, data presentation, and drawing conclusions. The results showed that the children's language skills through the application of the mind mapping method in the first cycle were 75%, and in the second cycle had increased to 92%. Based on the results of teacher observations in the implementation of cycle I, the children's language skills obtained a percentage value of 61.5%, and in cycle II increased to 92.3%. While the results of observations of children's activities in the implementation of the first cycle obtained a percentage of 54%, and in the second cycle, it increased to 85%. This study found that the teacher's assessment of this mind mapping method was an easy method to understand so that it was easy to apply in classroom learning. The implication of this research is that it is necessary to carry out further research on the application of the mind mapping method for other aspects of development. Keywords: Early Childhood, language Skills, Mind Mapping Learning Methods References: Abi-El-Mona, I., & Adb-El-Khalick, F. (2008). The influence of mind mapping on eighth graders’ science achievement. 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The surfacing of the coronavirus COVID-19 pandemic in the latter part of 2019 drastically forced school systems to restructure and go full-blast with remote learning. Despite the uncertainties, the educational sector must still meet academic ends and so must be resilient in facilitating flexible learning. This shift towards flexible "remote" learning has been predictable and has become, even, the most pragmatic alternative at this time towards providing effective learning delivery systems. To support flexible learning without compromising authenticity and shared identity in the context of natural science virtual teaching and learning, the researchers reviewed and consequently, proposed a recalibration of the instructional systems design (ISD) as used by Natural Science teachers and professors of the Mendiola Consortium from October 2020 through March 2021. 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ABSTRAK Penerapan kebijakan Capital Buffer sangat diperlukan untuk meningkatkan kualitas permodalan bank Syariah. Di satu sisi bank menghadapi dilema untuk tetap mempertahankan keamanan modalnya, atau memilih untuk meningkatkan keuntungan usahanya. Adapun tujuan penelitian ini adalah untuk mengetahui Capital Buffer Bank Umum Syariah di Indonesia serta faktor-faktor yang mempengaruhinya dengan menggunakan metode kausalitas melalui pendekatan kuantitatif. Bank Umum Syariah (BUS) sebanyak 14 BUS menjadi populasi, sedangkan untuk sampel diambil sebanyak 12 BUS selama lima tahun dengan tekhnik purposive sampling. Adapun teknik analisis data yang digunakan adalah analisis regresi data panel dengan aplikasi Eviews9. Capital Buffer menjadi variable dependen sedangkan variabel independennya adalah tingkat risiko pembiayaan bermasalah (NPF), tingkat profitabilitas (ROE), ukuran bank (Size) dan tingkat likuiditas (FDR). Hasil penelitian menunjukkan secara parsial tingkat risiko pembiayaan (NPF) tidak berpengaruh terhadap Capital Buffer, tingkat profitabilitas tidak berpengaruh terhadap Capital Buffer, ukuran bank (Size) berpengaruh signifikan negatif terhadap Capital Buffer dan tingkat likuiditas berpengaruh signifikan negatif terhadap Capital Buffer. Implikasi dari penelitian ini yaitu besar atau kecilnya NPF serta tingkat profitabilitas yang dimiliki bank tidak akan terlalu berpengaruh terhadap ketersediaan Capital Buffer, namun semakin besar ukuran bank (aset) dan tingkat likuiditas yang dimiliki bank akan menjadikan Capital Buffer suatu bank dalam keadaan stabil sehingga dalam hal ini bank harus senantiasa meningkatkan kualitas asset dan cadangan likuiditasnya. Kata Kunci: Capital Buffer, NPF, ROE, Bank Size, FDR. ABSTRACT The implementation of the Capital Buffer policy is very much needed to improve the quality of Islamic bank capital. On the one hand, the bank faces a dilemma to maintain the safety of its capital, or choose to increase its business profits. The purpose of this study is to determine the Capital Buffer of Islamic Commercial Banks in Indonesia and the factors that influence it by using the causality method through a quantitative approach. As many as 14 Sharia Commercial Banks (BUS) became the population, while the sample was taken by 12 BUS for five years using purposive sampling technique. The data analysis technique used is panel data regression analysis using the Eviews9 application. Capital Buffer is the dependent variable, while the independent variables are the level of non-performing financing risk (NPF), profitability (ROE), bank size (Size) and liquidity level (FDR). The results showed that partially the level of financing risk (NPF) had no effect on the Capital Buffer, the level of profitability had no effect on the Capital Buffer, the size of the bank (Size) had a significant negative effect on the Capital Buffer and the level of liquidity had a significantly negative effect on the Capital Buffer. The implication of this research is that the size of the NPF and the level of profitability owned by the bank will not greatly affect the availability of Capital Buffers, but the larger the size of the bank (assets) and the level of liquidity owned by the bank will make the Capital Buffer of a bank in a stable condition so that in terms of Banks must always improve the quality of their assets and liquidity reserves. Keywords: Capital Buffer, NPF, ROE, Bank Size, FDR. DAFTAR PUSTAKA Agustuty, L., & Ruslan, A. (2019). Determinan capital buffer pada industri perbankan. Movere Journal, 1(2), 164-174. Andhika, Y. D., & Suprayogi, N. (2017). 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Objetivo: Determinar la participación social a partir de la exploración de intereses ocupacionales y uso de los espacios de vida de los adultos mayores de 60 años del corregimiento de Obonuco de la ciudad de San Juan de Pasto. Metodología: Estudio de tipo cuantitativo descriptivo, con una muestra de 70 adultos mayores de 60 años, a quienes se les aplicó el Cuestionario de intereses ocupacionales para el adulto mayor, que determina el tipo de actividad, nivel de interés, frecuencia, autoeficacia percibida y con quién lo realiza, y la evaluación de espacios de vida con el cuestionario Life Space Assessment (LSA). Resultados: Las actividades que se presentan con mayor grado de interés son, asistir a misa, bailar, visitar familia y amigos, con una frecuencia de una vez por semana, con alta percepción de autoeficacia, sin ninguna compañía de algún familiar, amigo o cuidador, además de tener interés por participar de grupos de estudio. Conclusión: Prevalecen las relaciones intrafamiliares e intrapersonales, que han demostrado que llegar a esta etapa de la vida no es un impedimento para socializar y compartir con los suyos y la comunidad. Referencias: Acosta, C. y González-Celis, A. (2009). Actividades de la vida diaria en adultos mayores: la experiencia de dos grupos focales. Psicología y Salud, 19(2), 289-293. Acuña-Gurrola, M. y González-Celis, A. (2010). Autoeficacia y red de apoyo social en adultos mayores. Journal of Behavior, Health & Social Issues, 2(2), 71-81. Benavides, L. (2015). Política Pública de Envejecimiento y Vejez 2013-2023. Recuperado de http://www.idsn.gov.co/index.php/noticias/2102-politica-publica-departamental-de-envejecimiento-y-vejez-2013-2023-en-el-departamento-de-narino Camacho, S. y Lachuma, I. (2014). Prácticas de autocuidado, capacidad funcional y depresión en adultos mayores. Recuperado de http://repositorio.unapiquitos.edu.pe/handle/UNAP/3539 Canales, A. (2015). 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This paper analyzes the Islam Nusantara program of the Islamic Studies Institute of Nahdlatul Ulama (STAINU) and then of the Nahdlatul Ulama University of Indonesia (UNUSIA) that started in 2013. The largest Islamic social organization, Nahdlatul Ulama (NU) has emphasized the moderateness and tolerance of Islam in Indonesia and conceptualized its Islam as Islam Nusantara and started to disseminate this concept to stem the deepening conservative turn of Islam especially after the democratization in 1998. In order to disseminate Islam Nusantara more effectively, the NU-affiliated college (STAINU), later its university (UNUSIA) started the graduate program for Islam Nusantara. After elucidating the Islamic conservative turn and the propagation of Islam Nusantara both by NU and the state, this paper analyzes the theses and their abstracts and the biodata of authors of theses and sees how Islam Nusantara has been producing the proponents of Islam Nusantara. The paper finds that the authors of the theses are young and many of the theses analyze the harmonious Islamic adaptation to local cultures. The authors are male dominant and Java-born-dominant with the focus on their own birthplace. The paper concludes with the importance of more comparativeand critical analysis on local variations of Islam Nusantara in the future theses and dissertations so that the program can critically and objectively analyze the Islam Nusantara concept itself. Keyword: Islam Nusantara, Nahdlatul Ulama, UNUSIA Jakarta REFERENCE: Abdul Mun’im DZ. Mengukuhkan Jangkar Islam Nusantara, Tashwirul Afkar no.26, 2008. Abdurrahman Wahid. “Pribumisasi Islam.” Dalam Muntaha Azhari and Abdul Mun’im Saleh, eds. Islam Indonesia Menatap Masa Depan. Jakarta: P3M, 1989. Abdurrahman Wahid. “Melindungi dan Menyantuni Semua Paham.” Dalam Yenny Zannuba Wahid, Ahmad Suaedy et al., eds. Ragam Ekspresi Islam Nusantara. Jakarta: The Wahid Institute, 2008: h. xi-xii. Ahmad Najib Burhani. Islam Nusantara as a Promising Response to Religious Intolerance and Radicalism, Trends in Southeast Asia, 2018. No.21. Ahmad Suaedy. Islam, Minorities and Identity in Southeast Asia. Yogyakarta and Jakarta: inklusif and ISAIs UIN Yogya, 2018. Akhmad Sahal. “Prolog: Kenapa Islam Nusantara?” Dalam Akhmad Sahal dan Munawir Aziz eds. Islam Nusantara dari Ushul Fiqh hingga Paham Kebangsaan. Bandung: Mizan Pustaka, 2015. Akhmad Sahal dan Munawir Aziz eds. Islam Nusantara dari Ushul Fiqh hingga Paham Kebangsaan. Bandung: Mizan Pustaka, 2015. Anderson, Benedict. A Life Beyond Boundaries. Petaling Jaya: Strategic Information and Research Development Centre, 2016. Azymardi Azra. Islam Nusantara: Jaringan Global dan Lokal. Bandung: Mizan, 2002. Dawam Multazam. “Islam Nusantara, Dari NU untuk Dunia” (artikel diakses pada 10 January 2015 dari http://www.nu.or.id/post/read/60706/islam-nusantara-dari-nu-untuk-dunia). Fealy, Greg. “Nahdlatul Ulama and the Politics Trap.” New Mandala. (diakses pada 12 November 2019 pada https://www.newmandala.org/nahdlatul-ulama-politics-trap/), 2018. Fogg, Kavin W. “The Fate of Muslim Nationalism in Independent Indonesia.” PhD dissertation (Yale University), 2012. Formichi, Chiara. Islam and the Making of the Nation: Kartosuwiryo and Political Islam in 20th Century Indonesia. Leiden and Manoa: KITLV and Hawai’i University Press, 2011. Hefner, Robert W. “Islamic Schools, Social Movements, and Democracy in Indonesia.” Dalam Robert W. Hefner ed. Making Modern Muslim: the Politics of Islamic Education in Southeast Asia. Honolulu: University of Hawai’i Press, 2009: h. 55-105. Hefner, Robert. W. What Happened to Civil Islam? Islam and Democratisation in Indonesia, 20 Years On. Asian Studies Review. Vol.43. No.3, 2019: h. 375-396. Hoesterey, James Bourk. Public Diplomacy and the Global Dissemination of “Moderate Islam” Dalam Robert W. Hefner ed. Routledge Handbook of Contemporary Indonesia. London: Routledge, 2018: h. 406-416. IPAC (Institute for Policy Analysis of Conflict). After Ahok: The Islamist Agenda in Indonesia. IPCA Report No.44, 2018. Jadul Maula. Orientasi “Islam Nusantara”: Melahirkan “Insan (Kamil) Nusantara”. Tashwirul Afkar No. 13, 2006. Laffan, Michael, The Makings of Indonesian Islam: Orientalism and the Narration of a Sufi Past. New Jersey: Princeton University Press, 2011. Menchik, Jeremy. Islam and Democracy in Indonesia: Tolerance without Liberalism. Cambridge: Cambridge University Press, 2015. Nor Huda. Islam Nusantara: Sejarah Sosial Intelektual Islam di Indonesia. Yogyakarta: Ar-Ruzz Media, 2008. Pepinsky, Thomas B., Liddle, William R. and Saiful Mujani. Piety and Public Opinion: Understanding Indonesian Islam. Oxford: Oxford University Press, 2018. Power, Thomas P. Jokowi’s Authoritarian Turn and Indonesia’s Democratic Decline. Bulletin of Indonesian Economic Studies 53(3), 2018: h. 307-338. Robison, Richard and Hadiz, Vedi R. Reorganizing Power in Indonesia: The Politics of Oligarchy in An Age of Markets．London and New York: Routledge Curzon, 2004. Yenny Zannuba Wahid, Ahmad Suaedy et al. eds. Ragam Ekspresi Islam Nusantara. Jakarta: The Wahid Institute, 2015. Syafiq Hasyim. Islam Nusantara dalam Konteks: Dari Multikultralisma hingga Radkikalisme. Yogyakarta: Gading, 2018. van Bruinessen, Martin ed. Contemporary Developments in Indonesian Islam: Explaining the "Conservative Turn". Singapore: ISEAS, 2013. van Bruinessen, Martin. Introduction: Contemporary Developments in Indonesian Islam and the “Conservative Turn” of the Early Twenty-First Century. Dalam van Bruinessen, Martin ed. Contemporary Developments in Indonesian Islam: Explaining the "Conservative Turn". Singapore: ISEAS, 2013: h.1-20. van Bruinessen, Martin. Indonesian Muslim in a Globalising World: Westernization, Arabisation, and Indigenising Responses. RSIS Working Paper No. 311. Singapore: S. Rajaratnam School of International Studies, 2018. William Putra Utomo and others. Indonesia Millennial Report 2019. Jakarta: IDN Research Institute, 2019. News: 2013/2/25: STAINU Jakarta Kumpulkan Tim Pakar PPM Islam Nusantara. (diakses pada 10 November 2019 pada https://www.nu.or.id/post/read/43199/stainu-jakarta-kumpulkan-tim-pakar-ppm-islam-nusantara) 2013/7/3: STAINU Jakarta Luncurkan Pascasarjana Islam Nusantara. (diakses pada 10 November 2019 pada https://www.nu.or.id/post/read/45577/stainu-jakarta-luncurkan-pascasarjana-islam-nusantara) 2013/7/4: Islam Nusantara Diharapkan Jadi Solusi Kasus Intoleransi. (diakses pada 13 Desember 2019 pada https://www.merdeka.com/peristiwa/islam-nusantara-diharapkan-jadi-solusi-kasus-intoleransi.html) 2013/7/4: Mahasiswa Thailand Minati Studi Islam Nusantara Indonesia. (diakses pada 11 November 2019 pada https://news.okezone.com/read/2013/07/04/373/831915/mahasiswa-thailand-minati-studi-islam-nusantara-indonesia) 2015/4/14: Imam Aziz: Dunia Butuh NU (diakses pada 11 November 2019 pada https://www.nu.or.id/post/read/58831/imam-aziz-dunia-butuh-nu) 2015/10/9: Pascasarjana Islam Nusantara STAINU Jakarta Mulai Kuliah Perdana Hari Ini. (diakses pada 11 November 2019 pada https://www.nu.or.id/post/read/62673/pascasarjana-islam-nusantara-stainu-jakarta-mulai-kuliah-perdana-hari-ini) 2016/9/3: Siapakah Ahlussunnah Wal Jamaah. (diakses pada 11 November 2019 pada https://www.nu.or.id/post/read/70944/siapakah-ahlussunnah-wal-jamaah)

Ensuring that Older People have good quality of life is one of the major goals of any caregiver. Caregivers, which includes nurses, must be holistic in their provision of care to meet such a goal. Since one of the dimensions of quality of life is spirituality, these researchers sought to describe if any relationship exists between the caregivers’ spiritual care practices and the quality of life of the older people in their care. Institutionalized older people were surveyed using the Nurse Spiritual Care Therapeutics scale and WHO Quality of Life for Filipino Older People to measure the spiritual care practices of caregivers and the quality of life of Older People, respectively. Results show no significant relationship between the two variables, which may be due to the fact that quality of life is composed of several dimensions, in which spirituality is only one, and is multi-factorial in nature; suggesting that quality of life is influenced by several factors and how these factors interplay ultimately determine the quality of life of Older People. The researchers recommend that a mixed-method approach be used to further understand the lack of direct relationship between the two variables. References Abbasi, M., Farahani-Nia, M., Mehrdad, N., Azamgivari, and Haghani, H. (2014). Nursing students’ spiritual well-being, spirituality and spiritual care. Iran Journal of Nursing and Midwifery Research. 2014 May-Jun; 19(3): 242-247.Almeida-Brasil, C. C., Silveira, M. R., Silva, K. R., Lima, M. G., Faria, C. D. C. de M., Cardoso, C. L., Menzel, H.-J. K., Ceccato, M. das G. B. (2017). Qualidade de vida e características associadas: aplicação do WHOQOL-BREF no contexto da Atenção Primária à Saúde. Ciência & Saúde Coletiva, 22(5), 1705-1716. doi:10.1590/1413-81232017225.20362015Bai, M., & Lazenby, M. (2015). A systematic review of associations between spiritual well-being and quality of life at the scale and factor levels in studies among patients with cancer. Journal of Palliative Medicine, 18(3), 286-298. doi:10.1089/jpm.2014.0189Baldacchino, D. R. (2006). Nursing competencies for spiritual care. Journal of Clinical Nursing, 15(7), 885-896. doi:10.1111/j.1365-2702.2006.01643.xBerman, A., and Snyder, S. (2012). Kozier & Erb’s Fundamentals of nursing: concepts, process, and practice, 9th ed. WY: Pearson Canada, A. L., Murphy, P. E., Fitchett, G., & Stein, K. (2015). Reexamining the Contributions of Faith, Meaning, and Peace to Quality of Life: a Report from the American Cancer Society’s Studies of Cancer Survivors-II (SCS-II). Annals of Behavioral Medicine, 50(1), 79-86. doi:10.1007/s12160-015-9735-yCarpenter, K., Girvin, L., Kitner, W., & Ruth-Sahd, L. A. (2008). Spirituality. dimensions of critical care nursing, 27(1), 16-20.doi:10.1097/01.dcc.0000304668.99121Chen, J., Lin, Y., Yan, J., Wu, Y., and Hu, R. (2018). The effects of spiritual care on quality of life and spiritual well-being among patients with terminal illness: A systematic review. Palliative Medicine, 1-13. doi: 10.1177/0269216318772267 Chen, Y.-H., Lin, L.-C., Chuang, L.-L., & Chen, M.-L. (2017). The relationship of physiopsychosocial factors and spiritual wellbeingin elderly residents: Implications for evidence-based practice. Worldviews on Evidence-Based Nursing, 14(6), 484-491. doi:10.1111/wvn.12243Counted, V., Possamai, A., & Meade, T. (2018). Relational spirituality and quality of life 2007 to 2017: an integrative research review.health and quality of life outcomes, 16(1). doi:10.1186/s12955-018-0895-xCrimmins, EM (2015). Lifespan and healthspan: Past, preseny, promise. Gerontologist, 55(6):901-11. doi: 10.1093/geront/gnv130De Araújo, A. A., Rebouças Barbosa, R. A. S., de Menezes, M. S. S., de Medeiros, I. I. F., de Araújo, R. F., & de Medeiros, C. A. C. X. (2015). Quality of life, family support, and comorbidities in institutionalized elders with and without symptoms of depression. Psychiatric Quarterly, 87(2), 281-291. doi:10.1007/s11126-015-9386-yDe Almeida Moreira, P., Roriz, A. K. C., Mello, A. L., & Ramos, L. B. (2015). Quality of life of institutionalized elderly in Brazil. SocialIndicators Research, 126(1), 187-197. doi:10.1007/s11205-015-0888-7Fernández-Mayoralas, G., Rojo-Pérez, F., Martínez-Martín, P., Prieto-Flores, M.-E., Rodríguez-Blázquez, C., Martín-García, S., Rojo-Abuín, J.-M. and Forjaz, M.-J. (2015). Active ageing and quality of life: factors associated with participation in leisure activities among institutionalized older adults, with and without dementia. Aging & Mental Health, 19(11), 1031-1041. doi:10.1080/13607863.2014.996734Garcia, L.M.R., and Navarro, J.M.R. (2018). The impact of quality of life on the health of older people from a multidimensional perspective. Journal of Aging Research. 2018: 4086294. doi: 10.1155/2018/4086294Goldberg, B. (1998). Connection: an exploration of spirituality in nursing care. Journal of advanced nursing, 27(4):836-42. doi: 10.1046/j.1365-2648.1998.00596.x Haugan, G. (2014). The relationship between nurse–patient interaction and meaning-in-life in cognitively intact nursing home patients.Journal of Advanced Nursing 70(1), 107-120. doi: 10.1111/jan.12173Jacobs, J. (2009). Quality of life: what does it mean for general practice? British Journal of General Practice, 59(568), 807-808. doi:10.3399/bjgp09x472854Kalish, N. (2012). Evidence-based spiritual care: a literature review. Current Opinion Supportive and Palliative Care, 2012, 6:242-246. doi:10.1097/SPC.0b013e328353811cKhaje-Bishak, Y., Payahoo, L., Pourghasem, B., Jafarabadi, M.A. (2014). Assessing the quality of life in elderly people and related factors in Tabriz, Iran. Journal of Caring Sciences, 2014, 3(4), 257-263. doi:10.5681/jcs.2014.028Mamier, I. & Taylor, E. J. (2015). Psychometric evaluation of the nurse spiritual care therapeutics scale. Western Journal of Nursing Research. 37(5), 679-694. doi: 10.1177/0193945914530191Matos TDS, Meneguin S, Ferreira MLS, and Miot HA. (2017). Quality of life and religious-spiritual coping in palliative cancer carepatients. Rev. Latino-Am. Enfermagem; 25:e2910. doi:10.1590/1518-8345.1857.2910Parse, R. R. (Ed.). (1999). Illumination: The human becoming theory in practice and research. Boston, MA: Jones & Bartlett.Pinkas, J., Gujski, M., Humeniuk, E., Raczkiewicz, D., Bejga, P., Owoc, A., and Bojar, I. (2016). State of health and quality of life of women at advanced age. Medical Science Monitor, 2016; 22: 3095-3105. doi:10.12659/MSM.900572Şahin, Z.A., and Özdemir, F.K. (2016): Spirituality and spiritual care: A descriptive survey of nursing practices In Turkey, Contemporary Nurse. doi: 10.1080/10376178.2016.1221324Sawatzky, R. Ratner, P.A., and Chiu, L. (2005). A meta-analysis of the relationship between spirituality and quality of life. SocialIndicators Research. 72 (2) 153-188. doi: 10.1007/s11205-004-5577-xShrivastava, S.R., Shrivastava, P.S., Ramasamy, J. (2013). Role of selfcare in management of diabetes mellitus. Journal of Diabetes and Metabolic Disorder, 5;12(1):14. doi: 10.1186/2251-6581-12-14Walker, A. and Breitmaster, C. (2017). The provision of spiritual care in hospices: A study in four hospices in North Rhine-Westphalia. 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This study aims to determine the development of scientific publications, mapping the scope and theme of publications related to obesity in early childhood published in Scopus-indexed journals from 2013-2023. This study uses the Scopus database which is retrieved using the publish or perish application. From the results of data extraction, 200 articles were obtained with keywords in the article titled Childhood Obesity. This research uses keyword co-occurrence analysis to identify and explore the main fields and topics that appear in publications. The application used to analyze the data is Vos Viewer. Based on the results of the analysis, 7 clusters were obtained. This study provides information to researchers, especially researchers in Indonesia about publication trends related to Childhood obesity. It is hoped that this research can be a foundation for further research, scientific development, and implementation in the fields of early childhood, health, and physical education. Keywords: childhood obesity, early childhood education, bibliometrics. References: An, R. (2020). Projecting the impact of the coronavirus disease-2019 pandemic on childhood obesity in the United States: A microsimulation model. Journal of Sport and Health Science, 9(4), 302–312. https://doi.org/10.1016/j.jshs.2020.05.006 Biro, F. M., & Wien, M. (2010). Childhood obesity and adult morbidities. The American Journal of Clinical Nutrition, 91(5), 1499S-1505S. Cunningham, S. A., Kramer, M. R., & Narayan, K. M. V. (2014). Incidence of Childhood Obesity in the United States. New England Journal of Medicine, 370(5), 403–411. https://doi.org/10.1056/nejmoa1309753 Famelia, R., Tsuda, E., Bakhtiar, S., & Goodway, J. D. (2018). Relationships among perceived and actual motor skill competence and physical activity in Indonesian preschoolers. Journal of Motor Learning and Development, 6, S403–S423. https://doi.org/10.1123/jmld.2016-0072 Gao, Z., Zeng, N., Pope, Z. C., Wang, R., & Yu, F. (2019). Effects of exergaming on motor skill competence, perceived competence, and physical activity in preschool children. Journal of Sport and Health Science, 8(2), 106–113. https://doi.org/10.1016/j.jshs.2018.12.001 Genin, P. M., Lambert, C., Larras, B., Pereira, B., Toussaint, J. F., Baker, J. S., Tremblay, A., Thivel, D., & Duclos, M. (2021). How did the COVID-19 confinement period affect our physical activity level and sedentary behaviors? Methodology and first results from the French national ONAPS survey. Journal of Physical Activity and Health, 18(3), 296–303. https://doi.org/10.1123/JPAH.2020-0449 Giles, L. C., Whitrow, M. J., Davies, M. J., Davies, C. E., Rumbold, A. R., & Moore, V. M. (2015). Growth trajectories in early childhood, their relationship with antenatal and postnatal factors, and development of obesity by age 9 years: Results from an Australian birth cohort study. International Journal of Obesity, 39(7), 1049–1056. https://doi.org/10.1038/ijo.2015.42 Huang, S. Y., Hogg, J., Zandieh, S., & Bostwick, S. B. (2012). A ballroom dance classroom program promotes moderate to vigorous physical activity in elementary school children. American Journal of Health Promotion, 26(3), 160–165. https://doi.org/10.4278/ajhp.090625-QUAN-203 Ji, C. Y., & Cheng, T. O. (2008). Prevalence and geographic distribution of childhood obesity in China in 2005. In International journal of cardiology (Vol. 131, Issue 1, pp. 1–8). Elsevier. Jia, P., Xue, H., Zhang, J., & Wang, Y. (2017). Time trend and demographic and geographic disparities in childhood obesity prevalence in China—evidence from twenty years of longitudinal data. International Journal of Environmental Research and Public Health, 14(4). https://doi.org/10.3390/ijerph14040369 Kawuki, J., Ghimire, U., Papabathini, S. S., Obore, N., & Musa, T. H. (2021). A bibliometric analysis of childhood obesity research from China indexed in Web of Science. Journal of Public Health and Emergency, 5(February). https://doi.org/10.21037/jphe-20-95 Kesehatan RI, K. (2021). Epidemi Obesitas. In Epidemi Obesitas (pp. 1–8). Milliken, S., Allen, R. M., & Lamont, R. F. (2019). The role of antimicrobial treatment during pregnancy on the neonatal gut microbiome and the development of atopy, asthma, allergy and obesity in childhood. Expert Opinion on Drug Safety, 18(3), 173–185. Min, J., Fang Yan, A., & Wang, Y. (2018). Mismatch in Children’s Weight Assessment, Ideal Body Image, and Rapidly Increased Obesity Prevalence in China: A 10‐Year, Nationwide, Longitudinal Study. Obesity, 26(11), 1777–1784. Ogden, C. L., Carroll, M. D., Kit, B. K., & Flegal, K. M. (2014a). Prevalence of childhood and adult obesity in the United States, 2011-2012. Jama, 311(8), 806–814. https://doi.org/10.1001/jama.2014.732 Ogden, C. L., Carroll, M. D., Kit, B. K., & Flegal, K. M. (2014b). Prevalence of childhood and adult obesity in the United States, 2011-2012. Jama, 311(8), 806–814. https://doi.org/10.1001/jama.2014.732 Osunsan, O. K., Ijjo, A. T., Mugisha, J. F., Samuel, P., & Muhwezi, M. (2022). Publish or Perish’: A Systematic Review. Journal of Social Sciences and Management, 1. Ranjani, H., Mehreen, T. S., Pradeepa, R., Anjana, R. M., Garg, R., Anand, K., & Mohan, V. (2016). Epidemiology of childhood overweight & obesity in India: A systematic review. In Indian Journal of Medical Research (Vol. 143, Issue FEBRUARY, pp. 160–174). https://doi.org/10.4103/0971-5916.180203 Reyes-Olavarría, D., Latorre-Román, P. Á., Guzmán-Guzmán, I. P., Jerez-Mayorga, D., Caamaño-Navarrete, F., & Delgado-Floody, P. (2020). Positive and negative changes in food habits, physical activity patterns, and weight status during covid-19 confinement: Associated factors in the chilean population. International Journal of Environmental Research and Public Health, 17(15), 1–14. https://doi.org/10.3390/ijerph17155431 Russell, C. G., & Russell, A. (2019). A biopsychosocial approach to processes and pathways in the development of overweight and obesity in childhood: Insights from developmental theory and research. Obesity Reviews, 20(5), 725–749. Simmonds, M., Llewellyn, A., Owen, C. G., & Woolacott, N. (2016). Predicting adult obesity from childhood obesity: A systematic review and meta-analysis. Obesity Reviews, 17(2), 95–107. https://doi.org/10.1111/obr.12334 World Health Organisation. (2021). WHO releases guidelines to address overweight and obesity in. Zhang, X., Zhang, F., Yang, J., Yang, W., Liu, W., Gao, L., Peng, Z., & Wang, Y. (2018). Prevalence of overweight and obesity among primary school-aged children in Jiangsu Province, China, 2014-2017. PLoS One, 13(8), e0202681. World Health Organisation. (2021). WHO releases guidelines to address overweight and obesity in.

Digital natives’ generation is inseparable from gadgets, less socializing, lack of creativity and being an individualist. The digital native’s generation wants things that are instant and lack respect for the process. The preoccupation of children with gadgets makes children socially alienated or known as anti-social. Preschool play an important role in the development of the digital native’s generation and in the future can help children use gadgets with parents. As it is known, the digital native’s generation is a kindergarten child. This study aims to determine the role of preschools in helping the use of gadgets in the digital native generation. This study used a descriptive quantitative approach with simple random sampling technique was obtained 25 kindergarten principals in Pekanbaru City. Data was collected in the form of a questionnaire via google form. Data analysis uses percentages and is presented in the tabular form. The results of the study indicate that the role of preschools in the use of gadgets in digital native generation children in Pekanbaru City is included in the low category. Only a few preschools have organized parenting education for parents. There are almost no rules governing children's use of gadgets at home, and few preschools educate children on how to use gadgets properly. It is expected for teachers and preschools to add special programs in the curriculum to provide information about positive gadget use and parenting programs that discuss digital native generation and collaborate with parents to establish rules such as frequency, duration and content of children using gadgets. Keywords: Digital Native, Preschool, Gadgets References: Alia, T., & Irwansyah, I. (2018). Pendampingan orang tua pada anak usia dini dalam penggunaan teknologi digital [parent mentoring of young children in the use of digital technology]. Polyglot: Jurnal Ilmiah, 14(1), 65–78. Allen, K. A., Ryan, T., Gray, D. L., McInerney, D. M., & Waters, L. (2014). Social Media Use and Social Connectedness in Adolescents: The Positives and the Potential Pitfalls. The Australian Educational and Developmental Psychologist, 31(1), 18–31. https://doi.org/10.1017/edp.2014.2 Berlin, A., Törnkvist, L., & Barimani, M. (2016). Content and Presentation of Content in Parental Education Groups in Sweden. The Journal of Perinatal Education, 25(2), 87–96. https://doi.org/10.1891/1058-1243.25.2.87 Chapman, G., & Pellicane, A. (2014). Growing up social: Raising relational kids in a screen-driven world. Moody Publishers. Cho, K.-S., & Lee, J.-M. (2017). Influence of Smartphone Addiction Proneness of Young Children on Problematic Behaviors and Emotional Intelligence. Comput. Hum. Behav., 66(C), 303–311. https://doi.org/10.1016/j.chb.2016.09.063 Coie, J. D., & Dodge, K. A. (1988). Multiple sources of data on social behavior and social status in the school: A cross-age comparison. Child Development, 815–829. Crouch, A. (2017). Tech-Wise Family. Everyday Steps for Putting Technology in Its Proper Place. Baker Books. De Lima, L., & Castronuevo, E. (2016). Perception of parents on children’s use of gadgets. The Bedan Journal of Psychology, II, 26–34. Gani, S. A. (2017). Parenting Digital Natives: Cognitive, Emotional, and Social Developmental Challenges. Guralnick, M. J. (1999). Family and child influences on the peer‐related social competence of young children with developmental delays. Mental Retardation and Developmental Disabilities Research Reviews, 5(1), 21–29. Hosokawa, R., & Katsura, T. (2018). Association between mobile technology use and child adjustment in early elementary school age. PloS One, 13(7), e0199959. Jonathan, L. P., & Andrew, L. F. (2016). Depression in children and adolescents. University of Kansas, Clinical Child Psychology Program. Kabali, H. K., Irigoyen, M. M., Nunez-Davis, R., Budacki, J. G., Mohanty, S. H., Leister, K. P., & Bonner, R. L. (2015). Exposure and Use of Mobile Media Devices by Young Children. PEDIATRICS, 136(6), 1044–1050. https://doi.org/10.1542/peds.2015-2151 Kirschner, P. A., & De Bruyckere, P. (2017). The myths of the digital native and the multitasker. Teaching and Teacher Education, 67, 135–142. https://doi.org/10.1016/j.tate.2017.06.001 Kurniawan, A. R., Chan, F., Sargandi, M., Yolanda, S., Karomah, R., Setianingtyas, W., & Irani, S. (2019). Kebijakan Sekolah Dalam Penggunaan Gadget di Sekolah Dasar [School Policy on the Use of Gadgets in Elementary Schools]. Jurnal Tunas Pendidikan, 2(1), 72–81. Martin, D. J. (2001). Constructing Early Childhood Science. Delmar Thomson Learning, Inc,. Morrongiello, B. A., McArthur, B. A., Goodman, S., & Bell, M. M. (2015). Don’t touch the gadget because it’s hot! Mothers’ and children’s behavior in the presence of a contrived hazard at home: Implications for supervising children. Journal of Pediatric Psychology, 40 1, 85–95. Mueller, S., Remaud, H., & Chabin, Y. (2011). How strong and generalisable is the Generation Y effect? A cross‐cultural study for wine. International Journal of Wine Business Research, 23(2), 125–144. https://doi.org/10.1108/17511061111142990 NAEYC. (2012). Technology and interactive media as tools in early childhood programs serving children from birth through age 8. National Institute for Educational Policy Research. (2014). Zenkoku Gakuryoku Gakusyu Jyokyo Cyosa [Japanese]. Nielsen Company. (2009). Television, Internet, and mobile usage in the U.S.: A2/M2 Three Screen Report. Nielsen Company. Nielsen, M. (2012). Imitation, pretend play, and childhood: Essential elements in the evolution of human culture? Journal of Comparative Psychology, 126(2), 170–181. https://doi.org/10.1037/a0025168 Novianti, R., Febrialismanto, F., Puspitasari, E., & Hukmi, H. (2020). Meningkatkan pengetahuan orang tua dalam mendidik anak di era digital di Kecamatan Koto Gasib Kabupaten Siak Provinsi Riau [Increasing parental knowledge in educating children in the digital era in Koto Gasib Sub-district, Siak Regency, Riau Province]. Riau Journal of Empowerment, 3(3), 183–190. https://doi.org/10.31258/raje.3.3.183-190 Novianti, R., & Garzia, M. (2020). Penggunaan Gadget pada Anak; Tantangan Baru Orang Tua Milenial[Use of Gadgets in Children; Millennial Parents' New Challenge]. Jurnal Obsesi: Jurnal Pendidikan Anak Usia Dini, 4(2), 1000–1010. Pediatrics, A. A. O. (2016). American Academy of Paediatrics announces new recommendations for children’s media use. Advocacy & Policy. Radesky, J. S., & Christakis, D. A. (2016). Increased Screen Time: Implications for Early Childhood Development and Behaviour. Paediatric Clinics of North America, 63(5), 827–839. https://doi.org/10.1016/j.pcl.2016.06.006 Ransdell, S., Kent, B., Gaillard-Kenney, S., & Long, J. (2011). Digital immigrants fare better than digital natives due to social reliance: Digital immigrants and social reliance. British Journal of Educational Technology, 42(6), 931–938. https://doi.org/10.1111/j.1467-8535.2010.01137.x Rideout, V., &. Robb, M. B., & Robb, M. B. (2020). The commonsense census: Media use by kids aged zero to eight. Common Sense Media. Scott, F. L. (2021). Family mediation of preschool children’s digital media practices at home. Learning, Media, and Technology, 1–16. https://doi.org/10.1080/17439884.2021.1960859 Setianingsih, S. (2018). Dampak penggunaan gadget pada anak usia prasekolah dapat meningkatan resiko gangguan pemusatan perhatian dan hiperaktivitas [The impact of using gadgets on preschool-aged children can increase the risk of attention deficit disorder and hyperactivity]. Gaster, 16(2), 191–205. Sharkins, K. A., Newton, A. B., Albaiz, N. E. A., & Ernest, J. M. (2016). Preschool Children’s Exposure to Media, Technology, and Screen Time: Perspectives of Caregivers from Three Early Childcare Settings. Early Childhood Education Journal, 44(5), 437–444. https://doi.org/10.1007/s10643-015-0732-3 Sheedy, A. J., Brent, J., Dally, K., Ray, K., & Lane, A. E. (2021). Handwriting Readiness among Digital Native Kindergarten Students. Physical & Occupational Therapy In Pediatrics, 41(6), 655–669. https://doi.org/10.1080/01942638.2021.1912247 Steiner-Adair, C., & Barker, T. H. (2013). The Big Disconnect (1st ed.). Harper Collins. Strasburger, V. C., Jordan, A. B., & Donnerstein, E. (2010). Health effects of media on children and adolescents. Pediatrics, 125(4), 756–767. Sugiyono. (2017a). Statistika untuk Penelitian[Statistics for Research]. Alfabeta. Sugiyono, P. (2017b). Metode Penelitian Pendidikan: Pendekatan Kuantitatif, Kualitatif, R&D [Educational Research Methods: Quantitative, Qualitative, R&D Approach]. Cetakan Ke-25. Bandung: CV Alfabeta. Suhana, M. (2018). Influence of Gadget Usage on Children’s Social-Emotional Development. 169(Icece 2017), 224–227. https://doi.org/10.2991/icece-17.2018.58 Sylva, K. (1994). School Influences on Children’s Development. Journal of Child Psychology and Psychiatry, 35(1), 135–170. https://doi.org/10.1111/j.1469-7610.1994.tb01135.x Takeuchi, H., Taki, Y., Hashizume, H., Asano, K., Asano, M., Sassa, Y., Yokota, S., Kotozaki, Y., Nouchi, R., & Kawashima, R. (2016). Impact of videogame play on the brain’s microstructural properties: Cross-sectional and longitudinal analyses. Molecular Psychiatry, 21(12), 1781–1789. Test, J. E., Cunningham, D. D., & Lee, A. C. (2010). Talking With Young Children: How Teachers Encourage Learning. Dimensions of Early Childhood, 38(3), 3–14. Tootell, H., Freeman, M., & Freeman, A. (2014). Generation Alpha at the Intersection of Technology, Play and Motivation. 2014 47th Hawaii International Conference on System Sciences, 82–90. https://doi.org/10.1109/HICSS.2014.19 Twenge, J. M. (2017). IGen: Why today’s super-connected kids are growing up less rebellious, more tolerant, less happy—And completely unprepared for adulthood—And what that means for the rest of us. Simon and Schuster. UNESCO. (2014). Information and Communication Technology (ICT) In Education in Asia. Information Papers, 6(22), 6. UNICEF. (2017). UNICEF for Every Child. The State of The World’s Children 2017. Children in a Digital World. Valkenburg, P. M., Peter, J., & Schouten, A. P. (2006). Friend Networking Sites and Their Relationship to Adolescents’ Well-Being and Social Self-Esteem. CyberPsychology & Behavior, 9(5), 584–590. ht

Lung cancer is a malignant disease in the lung where abnormalities caused by collection of genetic changes in the epithelial cells of the airway, which lead to cell proliferation that cannot be controlled. This study was conducted to determine the characteristics of lung cancer patients in Haji Adam Malik General Hospital Medan in 2016-2018. This research is a descriptive study with a case series approach. The study population was 311 lung cancer patients using Total Sampling method. The tendency of inpatient lung cancer patients visiting H. Adam Malik General Hospital Medan in 2016-2018 has decreased. The highest proportion of patients with lung cancer based on sociodemography obtained 65-69 years old age group, men with 3: 1 sex ratio, work of farmers, living outside the city of Medan, the main complaint was more than one complaint, had a history of smoking, no pleural effusion occurred, the type of adenocarcinoma histology and the method of taking a cytological fluid specimen. There was a statistically significant relationship between age with sex, sex with occupation, sex with smoking history, occupation with primary complaints, occupation with smoking history, and histology type by specimen collection and there rest have no statistically significant difference.

In this study, cobalt-zinc ferrite (Co0.5Zn0.5Fe2O4) was obtained by the glycine-nitrate method followed by annealing in a high-temperature furnace at a temperature of 1300 °С. The qualitative composition and its microstructural characteristics were determined using energy-dispersive X-ray spectroscopy, X-ray diffraction analysis, and scanning electron microscopy.The analysis of the micrographs demonstrated that the cobalt-zinc ferrite micropowder obtained after thermal annealing has an average particle size of 1.7±1 μm. The analysis of XRD data showed that the annealed cobalt-zinc ferrite micropowder has a cubic crystal structure with a lattice parameter of a = 8.415 Å. Using the Scherrer and Williamson-Hall equations we calculated the average sizes of the coherent scattering regions, which were commensurate with the size of crystallites: according to the Scherrer equation D = 28.26 nm and according to the Williamson-Hall equation D = 33.59 nm and the microstress value e = 5.62×10–4 in the ferrite structure.Using a vector network analyser, the electromagnetic properties of a composite material based on synthesized cobalt-zinc ferrite were determined. The frequency dependences of the magnetic and dielectric permeability values from the measured S-parameters of the composite material (50% ferrite filler by weight and 50% paraffin) were determined using the Nicolson-Ross-Weir method and were in the range of 0.015–7 GHz. The analysis of the graphs of the dependence of the magnetic permeability on the frequency of electromagnetic radiation revealed a resonance frequency of fr ≈ 2.3 GHz. 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ABSTRACT This study aimed to investigate the impact of Sharia Supervisory Board (SSB) on Islamic Social Responsibility (ISR) by Islamic Commercial Banks in Indonesia. Secondary data were collected from the annual reports of 14 Islamic Commercial Banks in Indonesia from 2010 to 2020, resulting in 125 firm-year data. A panel data regression was applied to analyze the data. The analysis results show that SSB age, cross-membership, and meeting frequency have a positive effect on ISR, whereas size has a negative effect. However, this analysis results did not manage to support the effect of SSB qualifications (Ph.D.) and expertise on ISR. The findings imply that SSB needs to increase the frequency of meetings to improve its supervisory function over Shariah banks' management, including in encouraging more comprehensive ISR disclosure. The contribution of this research is that research focuses on the characteristics of SSB on ISR by using Sharia Enterprise Theory (SET) to provide a better understanding of how these factors influence the implementation of ISR in the sharia context. Keywords: Sharia Supervisory Board Characteristics, Social Reporting, Islamic Bank, Indonesia ABSTRAK Tujuan dari penelitian ini adalah untuk menyelidiki dampak SSB terhadap Islamic Social Reporting (ISR) oleh Bank Umum Syariah di Indonesia. Data sekunder dikumpulkan dari laporan tahunan 14 Bank Umum Syariah di Indonesia sejak 2010 hingga 2020, menghasilkan 125 data firm-year. Regresi data panel diterapkan untuk menganalisis data. Hasil analisis menunjukkan bahwa usia SSB, lintas keanggotaan, dan frekuensi pertemuan berpengaruh positif pada ISR, sedangkan ukuran berpengaruh negatif. Namun hasil analisis ini tidak mendukung pengaruh kualifikasi (Ph.D.) dan keahlian SSB terhadap ISR. Temuan ini menyiratkan bahwa DPS perlu meningkatkan frekuensi pertemuan dalam rangka meningkatkan fungsi pengawasan terhadap manajemen bank syariah, termasuk dalam mmendorong pengungkapan ISR yang lebih komprehensif. kontribusi dalam penelitian ini yaitu Penelitian memfokuskan pada karakteristik SSB terhadap ISR dengan menggunakan Syariah Enterprise Theory (SET) untuk memberikan pemahaman yang lebih baik tentang bagaimana faktor-faktor tersebut mempengaruhi pelaksanaan ISR dalam konteks syariah. Kata Kunci: Karakteristik Dewan Pengawas Syariah, Pelaporan Sosial, Bank Syariah, Indonesia. REFERENCES Abdullah, W. A. W., Percy, M., & Stewart, J. (2013). Shari’ah disclosures in Malaysian and Indonesian Islamic banks The Shari’ah governance system. Journal of Islamic Accounting and Business Research, 4(2), 100–131. doi:10.1108/JIABR-10-2012-0063 Adiertanto, C. P., & Chariri, A. (2013). 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ABSTRAKPasar modal menjadi salah satu sarana investasi bagi masyarakat dalam menyalurkan harta yang dimiliki sehingga harta tersebut tidak hanya disimpan tetapi diinvestasikan pada instrument keuangan yang ada pada pasar modal agar terjadi perputaran dan memberikan manfaat bagi pemilik harta sebagai pemilik modal dan juga masyarakatnya muslim lainnya. Reksadana menjadi salah satu instrument pasar modal yang menjadi wadah bagi investor dalam menyisihkan hartanya. Kinerja reksadana syariah menjadi faktor investor mempercayakan kepada manajer investasi dalam mengelola portfolio. Studi ini untuk melihat kemampuan pemilihan saham dan kemampuan penetapan waktu dalam menilai kinerja reksadana saham syariah. Pengambilan sampel sebanyak 8 perusahaan manajer investasi dengan teknik purposive sampling dan metode analisis regresi linier berganda. Hasil penelitian yang diperoleh menyimpulkan kemampuan pemilihan saham memberikan pengaruh positif dan tidak signifikan serta kemampuan penetapan waktu memberikan pengaruh positif signifikan terhadap kinerja reksadana saham syariah.Kata Kunci: Kemampuan Pemilihan Saham, Kemampuan Penetapan Waktu, Kinerja, Reksadana Saham Syariah. ABSTRACTThe capital market is one of the investment facilities for the community in distributing their assets so that these assets are not only stored but invested in financial instruments that exist in the capital market so that turnover occurs and provides benefits for property owners as capital owners and also other Muslim communities. Mutual funds are one of the capital market instruments that are a place for investors to set aside their assets. The performance of sharia mutual funds is a factor for investors to trust investment managers in managing their portfolios. This study is to see the ability of stock selection and timing ability in assessing the performance of Islamic stock mutual funds. A sampling of 8 investment management companies with purposive sampling technique and multiple linear regression analysis methods. The results of the study concluded that the ability of stock selection has a positive and insignificant effect and the ability to determine timing has a significant positive effect on the performance of Islamic stock mutual funds.Keywords: Stock Selection Skill, Market Timing Ability, Performance, Sharia Stock Funds. DAFTAR PUSTAKAAnita, A. (2013). Pengukuran pemilihan saham dan penetapan waktu menggunakan model treynor-mazuy pada reksadana syariah di Indonesia. Etikonomi, 12(1), 1-20. https://doi.org/10.15408/etk.v12i1.1898Ghozali, I. (2012). Application of multivariate analysis with SPSS program. Semarang: Diponegoro University Publishing Agency.Hermawan, D., & Wiagustini, N. (2016). Pengaruh inflasi, suku bunga, ukuran reksa dana, dan umur reksa dana terhadap kinerja reksa dana. E-Jurnal Manajemen Universitas Udayana, 5(5), 3106-3133.Kharisma, A. W., & Isdaryadi, F. W. (2017). Evaluasi kemampuan manajer investasi reksadana saham berdasarkan market timing dan stock selection skill. Modus, 29(1), 37–50.Lestari, W. R. (2016). Kinerja reksadana saham syariah dan reksadana saham konvensional. Jurnal Magister Manajemen, 1(1), 116–128. https://jurnal.darmajaya.ac.id/index.php/jmmd/article/view/531Maulana, F., & Ardiansari, A. (2018). Pemilihan saham dan waktu perdagangan pada reksadana syariah saham di Indonesia. Management Analysis Journal, 7(1), 12–23. https://doi.org/10.15294/maj.v7i1.17133Ramayanti, T. P., & Purnamasari, K. (2018). Kemampuan pemilihan saham dan penetapan waktu pada manajer investasi reksa dana saham di Indonesia. Esensi: Jurnal Bisnis Dan Manajemen, 8(1), 29–40. https://doi.org/10.15408/ess.v8i1.6552Sabila, F. H. (2019). Stock selection dan market timing ability reksa dana syariah saham di Indonesia. Journal of Economic, Public, and Accounting (JEPA), 1(2), 68–81. https://doi.org/10.31605/jepa.v1i2.275Sari, A. P. N., & Purwanto, A. (2012). Analisis stock selection skills, market timing ability, size reksadana, umur reksadana dan expence ratio terhadap kinerja reksadana saham yang terdaftar di Bursa Efek Indonesia periode tahun 2006-2010. Journal of Finance, 1(1), 10–12.Sari, M. M., Mulyati, S., & Widarwati, E. (2019). The effect of stock selection skill, market timing ability, turnover ratio, and cash flow on sharia mutual funds performance (Case study of sharia mutual fund companies registered in OJK from 2011 to 2014). Journal of Accounting and Business Issues, 1(1), 69–78. https://ojs.stiesa.ac.id/index.php/jabiWaridah, W., & Mediawati, E. (2016). Analisis kinerja reksadana syariah. Jurnal Riset Akuntansi Dan Keuangan, 4(2), 1077–1086. https://doi.org/10.17509/jrak.v4i2.4043

This paper presents a theoretical investigation with the objective of identifying the basic competences to be acquired and developed in the language teaching-learning process, especially in virtual contexts. The study herein presented, of bibliographic nature, evidences a discussion and reflections on the theme competences and the representativeness of the communicative-digital domain, in the production and sharing of information, in the written and oral modality. The results achieve three basic skills : interacion through Information and Communication Technologies, creation of digital contents and sharing digital contents in the target language.ResumoEste artigo apresenta uma investigação teórica, com o objetivo de identificar as competências básicas a serem adquiridas e desenvolvidas no processo de ensino-aprendizagem de línguas, especialmente em contextos virtuais. O estudo em questão, de natureza bibliográfica, evidencia uma discussão e reflexões sobre a temática competências e a representatividade do domínio comunicativo-digital na produção e compartilhamento de informações, na modalidade escrita e oral. Os resultados evidenciam três competências básicas: interação por meio das Tecnologias de Informação e Comunicação, criação de conteúdos digitais e compartilhamento de conteúdos na língua-alvo.Resumen Este artículo presenta una investigación teórica con el objetivo de identificar las competencias básicas que vayan a ser adquiridas y desarrolladas en el proceso de enseñanza y aprendizaje de lenguas, especialmente en contextos virtuales. El estudio en cuestión, de naturaleza bibliográfica, evidencia una discusión y reflexiones sobre el tema competencias y la representatividad del dominio comunicativo-digital, en la producción y el intercambio de información, en la modalidad escrita y oral. Los resultados comprenden tres competencias básicas: interacción por medio de las Tecnologías de Información y Comunicación, creación de contenidos digitales e intercambio de contenidos en la lengua.Palavras-chave: Ensino de línguas, Competências, Competência comunicativa, Tecnologias.Keywords: Language Teaching, Competences, Communicative competence, Technologys.Palabras claves: Enseñanza de lenguas, Competencias, Competencia cumunicativa, Tecnologías.ReferencesALCARÁ, Adriana Rosecler et al. Fatores que influenciam o compartilhamento da informaçaõ e do conhecimento. Perspectivas em Ciência da Informação, v.14, n.1, p. 170-191, jan./abr., 2009. Disponível em: http://www.scielo.br/pdf/pci/v14n1/v14n1a12. Acesso em: 15 mar. 2019.AREA MOREIRA, Manuel. La alfabetización en la sociedad digital. In: Alfabetización digital y competencias informacionales. Colección Fundación Telefónica. Espanha: Editorial Ariel, p. 3-40, 2012.BARBERO ANDRÉS, J. et al. 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Ab initio calculations were used to analyze interactions of with 1–4 molecules of NH3at the MP2/6-311++G(d,p) and the B3LYP/6-311++G(d,p) computational levels. In addition to H3B–H⋯H–NH2dihydrogen bond, the H2N–H⋯NH3hydrogen bonds were also predicted in clusters. Negative cooperativity in clusters constructed from mixed H3B–H⋯H–NH2dihydrogen and H2N–H⋯NH3hydrogen bonds are more remarkable. The negative cooperativity increases with size and number of hydrogen bonds in cluster. The B–H stretching frequencies show blue shifts with respect to cluster formation. Greater blue shift in stretching frequencies was predicted for B–H bonds which did not contribute to dihydrogen bonding with NH3molecules. The structures were analyzed with the atoms in molecules (AIM) methodology.

Objectives Mirtazapine is commonly used in veterinary medicine at doses of 1.88 or 3.75 mg as an appetite stimulant. The objectives of this study were to determine the most common adverse effects reported and the dose associated with these signs. Methods Records of cats with mirtazapine exposure (2006–2011) were obtained from the American Society for the Prevention of Cruelty to Animals’ Animal Poison Control Center. The following parameters were recorded: signalment, weight, outcome, agent ingested, amount ingested, route of exposure, clinical signs observed, intended of use, onset time of signs and duration of signs. Results The 10 most commonly observed adverse effects reported in 84 cats exposed to mirtazapine included vocalization (56.0% of cats; mean dose 2.56 mg/kg), agitation (31.0%; 2.57 mg/kg), vomiting (26.2%; 2.92 mg/kg), abnormal gait/ataxia (16.7%; 2.87 mg/kg), restlessness (14.3%; 3.55 mg/kg), tremors/trembling (14.3%; 2.43 mg/kg), hypersalivation (13.0%; 2.89 mg/kg), tachypnea (11.9%; 3.28 mg/kg), tachycardia (10.7%; 3.04 mg/kg) and lethargy (10.7%; 2.69 mg/kg). Fifty-nine (70.2%) cases were considered accidental ingestions and 25 (29.8%) cases were given mirtazapine as prescribed. The doses associated with signs of toxicity were 15.00 mg (40 cats), 3.75 mg (25 cats), 7.50 mg (four cats), 30.00 mg (one cat), 18.75 mg (one cat), 11.25 mg (one cat), 5.80 mg (one cat) and 1.88 mg (one cat). For cats with available information, the onset of clinical signs ranged from 15 mins to 3 h, and time to resolution of clinical signs ranged from 12–48 h. Conclusions and relevance The greater number of adverse effects at 3.75 mg rather than 1.88 mg suggests that the latter may be a more appropriate starting dose for stimulating appetite while limiting toxicity. The benefit of dispensing exact doses of mirtazapine is implied given the likelihood of accidental administration of a full tablet (15 mg) and the resulting toxicity.

Abstract Background: Hereditary cancer syndromes explain 5-10% of all cancer cases. Germline pathogenic variants in BRCA1 and BRCA2 genes (BRCA) are present in 2-3% of all breast cancer (BC), and 15% of all ovarian cancer (OC) cases. BRCA1 and BRCA2 pathogenic variants (PV) represent 25-28% of BC and 40% of OC patients with a positive familial history. BRCAs are the most studied genes for the prevalence, family history, preventive surgeries, and target treatment options in both BC and OC. There are other genes, important in the diagnosis, pathogenesis, and treatment options of the patients: TP53, PALB2, CHEK2, among others. This study aims to identify the prevalence of non- BRCA genes related to the development of hereditary breast and ovarian cancer syndrome in patients of Northeast Mexico. Methods: This is a multicenter study that recruited patients from two reference oncology centers in Nuevo Leon, Mexico: the CECIL (The CUCC Early Cancer Detection Clinic) Hereditary Cancer Registry and Hereditary Cancer Program from Tec Salud. From March of 2016 to March of 2023, a total of 872 patients meeting NCCN criteria were evaluated by Medical Geneticists from both centers and were tested with NGS multigene cancer panels. Results: A total of 665 (76.26%) patients with a clinical diagnosis of HBOC (Hereditary Breast Hereditary Cancer Syndrome) were included. We found 310 (46.6%) patients had at least one variant, 180 (58%) with at least one pathogenic variant, and 130 (41%) with a VUS (a variant of uncertain significance). BRCA1 was found in 79 (43.8%) and BRCA2 in 32 (17.7%) of all PV. Non-BRCA PV were found in 69 (38.3%) patients: 4 ATM, 2 BLM, 3 BRIP1, 22 CHEK2, 4 CDKN2A, 5 MUTYH, 10 PALB2, 4 RAD51C, 2 SDHA, 2 TP53, 2 WRN, CDH1, CDK4, DICER, MSH3, NBN, PTEN, RAD50, USH2A one of each. Is remarkable that 19 of the 22 patients with CHEK2 and 5 of the 10 patients with PALB2 had the recurrent PV c.707T&gt;C and c.2167_2168del, respectively. Conclusions: Non-BRCA PV in Northern Mexico corresponds to one-third of the BC and OC cases, including HRD (homologous recombination deficiency) genes. HDR patient carriers are potential targets of iPARP therapies. This project reinforces the fact that multigene panels should be employed to ensure a complete diagnosis in hereditary cancer patients. Citation Format: Carlos H. Burciaga-Flores, Diana C. Perez-Ibave, Maria L. Garza-Rodriguez, Oscar Vidal-Gutierrez, Cynthia M. Villarreal-Garza, Dione Aguilar y Mendez. Non-BRCA variants in hereditary breast and ovarian cancer patients in the Northern Mexico population [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3947.

Modeling uncertainties in the input parameters of computer simulations is an established way to account for inevitably limited knowledge. To overcome long run-times and high demand for computational resources, a surrogate model can replace the original simulation. We use spatially adaptive sparse grids for the creation of this surrogate model. Sparse grids are a discretization scheme designed to mitigate the curse of dimensionality, and spatial adaptivity further decreases the necessary number of expensive simulations. We combine this with B-spline basis functions which provide gradients and are exactly integrable. We demonstrate the capability of this uncertainty quantification approach for a simulation of the Hokkaido Nansei–Oki Tsunami with anuga. We develop a better understanding of the tsunami behavior by calculating key quantities such as mean, percentiles and maximum run-up. We compare our approach to the popular Dakota toolbox and reach slightly better results for all quantities of interest. References B. M. Adams, M. S. Ebeida, et al. Dakota. Sandia Technical Report, SAND2014-4633, Version 6.11 User’s Manual, July 2014. 2019. https://dakota.sandia.gov/content/manuals. J. H. S. de Baar and S. G. Roberts. Multifidelity sparse-grid-based uncertainty quantification for the Hokkaido Nansei–Oki tsunami. Pure Appl. Geophys. 174 (2017), pp. 3107–3121. doi: 10.1007/s00024-017-1606-y. H.-J. Bungartz and M. Griebel. Sparse grids. Acta Numer. 13 (2004), pp. 147–269. doi: 10.1017/S0962492904000182. M. Eldred and J. Burkardt. Comparison of non-intrusive polynomial chaos and stochastic collocation methods for uncertainty quantification. 47th AIAA. 2009. doi: 10.2514/6.2009-976. K. Höllig and J. Hörner. Approximation and modeling with B-splines. Philadelphia: SIAM, 2013. doi: 10.1137/1.9781611972955. M. Matsuyama and H. Tanaka. An experimental study of the highest run-up height in the 1993 Hokkaido Nansei–Oki earthquake tsunami. National Tsunami Hazard Mitigation Program Review and International Tsunami Symposium (ITS). 2001. O. Nielsen, S. Roberts, D. Gray, A. McPherson, and A. Hitchman. Hydrodymamic modelling of coastal inundation. MODSIM 2005. 2005, pp. 518–523. https://www.mssanz.org.au/modsim05/papers/nielsen.pdf. J. Nocedal and S. J. Wright. Numerical optimization. Springer, 2006. doi: 10.1007/978-0-387-40065-5. D. Pflüger. Spatially Adaptive Sparse Grids for High-Dimensional Problems. Dr. rer. nat., Technische Universität München, Aug. 2010. https://www5.in.tum.de/pub/pflueger10spatially.pdf. M. F. Rehme, F. Franzelin, and D. Pflüger. B-splines on sparse grids for surrogates in uncertainty quantification. Reliab. Eng. Sys. Saf. 209 (2021), p. 107430. doi: 10.1016/j.ress.2021.107430. M. F. Rehme and D. Pflüger. Stochastic collocation with hierarchical extended B-splines on Sparse Grids. Approximation Theory XVI, AT 2019. Springer Proc. Math. Stats. Vol. 336. Springer, 2020. doi: 10.1007/978-3-030-57464-2_12. S Roberts, O. Nielsen, D. Gray, J. Sexton, and G. Davies. ANUGA. Geoscience Australia. 2015. doi: 10.13140/RG.2.2.12401.99686. I. J. Schoenberg and A. Whitney. On Pólya frequence functions. III. The positivity of translation determinants with an application to the interpolation problem by spline curves. Trans. Am. Math. Soc. 74.2 (1953), pp. 246–259. doi: 10.2307/1990881. W. Sickel and T. Ullrich. Spline interpolation on sparse grids. Appl. Anal. 90.3–4 (2011), pp. 337–383. doi: 10.1080/00036811.2010.495336. C. E. Synolakis, E. N. Bernard, V. V. Titov, U. Kânoğlu, and F. I. González. Standards, criteria, and procedures for NOAA evaluation of tsunami numerical models. NOAA/Pacific Marine Environmental Laboratory. 2007. https://nctr.pmel.noaa.gov/benchmark/. J. Valentin and D. Pflüger. Hierarchical gradient-based optimization with B-splines on sparse grids. Sparse Grids and Applications—Stuttgart 2014. Lecture Notes in Computational Science and Engineering. Vol. 109. Springer, 2016, pp. 315–336. doi: 10.1007/978-3-319-28262-6_13. D. Xiu and G. E. Karniadakis. The Wiener–Askey polynomial chaos for stochastic differential equations. SIAM J. Sci. Comput. 24.2 (2002), pp. 619–644. doi: 10.1137/S1064827501387826.

A preliminary study to determine the group of compound contained in the ethanolic extract of mahagony (Swietenia mahagoni L. Jacq.) seeds and its inhibitory activity to a-glucosidase enzyme has been done. The information from this study will be used in the further investigation about the specific constituents related to the bioactivity. The seed was grounded and then extracted with ethanol by maceration technique. The crude extract was separated with liquid-liquid extraction by using n-hexane, ethyl acetate, and methanol as the solvents. The best eluent for isolation, chloroform:ethanol (1:1), was determined by thin layer chromatography while alumina as stationary phase. The isolation step with column chromatography gave two types of isolates, yellow and colorless isolate. In order to get information about the compound, the crude extract was subjected to phytochemical assignment and the isolate with the better activity was analyzed by infrared spectroscopy. The inhibitory activity for the yellow isolate with IC50 as 19.345 ppm was better than the colorless isolate. Therefore, the IR spectroscopy assay was subjected to the yellow isolate. Based on the comparison IR spectra with literatures, it has suggested that the yellow isolate contains tetranortriterpenoid or limonoid group.Keywords: Swietenia mahagoni L. Jacq., diabetes type 2, a-glucosidase, tetranortriterpenoidREFERENCE World Health Organization. Global report on diabetes. http://www.who.int. Accessed on 18 July 2017.Kementerian Kesehatan Republik Indonesia. 2014. Situasi dan analisis diabetes. Jakarta: Pusat Data dan Informasi Kemenkes RI.Dutta, M., Raychaudhuri, U., Chakroborty, R., and Maji, D. 2011. Role of diet and plants on diabetic patients - a critical appraisal. Science and Culture. 77 (3–4).Eid, A.M.M., Elmarzugi, N.A., and El-Enshasy, H.A. 2013. 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Abstract Background H syndrome ([OMIM] 602782) is an autosomal recessive disorder with systemic manifestations and characteristic skin lesions, caused by mutations of the SLC29A3 gene. Short stature and diabetes mellitus are the major endocrine problems related to H syndrome, however, clear data from clinical follow-up of H syndrome patients is lacking in the literature. Case presentation Here, we present follow-up of a Turkish girl diagnosed with H syndrome at the age of 10 with a homozygous 310(c.933T>A, p.C310X) early stop codon mutation on exon 6 of the SLC29A3 gene. She had severe short stature non-responsive to growth hormone (GH) treatment and gluten-free diet despite low GH levels and celiac antibody positivity. She developed insulin dependent diabetes mellitus (IDDM) symptoms 6 years after the initial diagnosis. Conclusions H syndrome patients can develop IDDM years after characteristic symptoms. Short stature in H syndrome patients may not respond to GH replacement or gluten-free diet alone.