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Artykuły w czasopismach na temat „2001 n-022”

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1

Schultheis, Christian P., Mohammed A. Raheem i Michael C. Perry. "Second-Line Chemotherapy for Small-Cell Lung Cancer: A Review". Clinical Lung Cancer 3, nr 2 (listopad 2001): 118–24. http://dx.doi.org/10.3816/clc.2001.n.022.

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Rutar, Frank J., Samuel C. Augustine, Mark S. Kaminski, Richard L. Wahl, Jeffry A. Siegel i David Colcher. "Feasibility and Safety of Outpatient Bexxar® Therapy (Tositumomab and Iodine I 131 Tositumomab) for Non-Hodgkin's Lymphoma Based on Radiation Doses to Family Members". Clinical Lymphoma 2, nr 3 (grudzień 2001): 164–72. http://dx.doi.org/10.3816/clm.2001.n.022.

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Martín, Miguel. "Platinum Compounds in the Treatment of Advanced Breast Cancer". Clinical Breast Cancer 2, nr 3 (październik 2001): 190–208. http://dx.doi.org/10.3816/cbc.2001.n.022.

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AYAZ, S., B. A. McKENZIE, G. D. HILL i D. L. McNEIL. "Nitrogen distribution in four grain legumes". Journal of Agricultural Science 142, nr 3 (czerwiec 2004): 309–17. http://dx.doi.org/10.1017/s0021859604004356.

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The partitioning of above ground nitrogen (N) in chickpea (Cicer arietinum), lentil (Lens culinaris), lupin (Lupinus angustifolius) and pea (Pisum sativum) at crop maturity was investigated. The plants were grown at different plant populations and sowing depths in 1998/99 and 1999/2000 in Canterbury, New Zealand. In all four legumes the N concentration was highest in seed (29–36 mg/g N) followed by senescent leaves. The lowest N concentration was in stems. Lupin had the highest seed N yield at 16·82 and 19·29 g/m2 followed by chickpea at 10·26 and 13·10 g/m2, in 1998/99 and 1999/2000, respectively. Lentil had the lowest N concentrations and yield. The distribution of N to all legume plant parts increased as population increased up to twice the optimum and 400 plants/m2 in 1998/99 and 1999/2000, respectively. Over all plant populations, the nitrogen harvest index (NHI) was stable in each of the four species across the two seasons. However, the NHI changed with changes in plant population and sowing depth. The N accumulation efficiency (EN) was highest in lentil at 0·024 and 0·027 g N/g DM and lowest in chickpea at 0·018 and 0·021 g N/g DM in 1998/99 and 1999/2000, respectively. The NHI and the crop harvest index (CHI) were correlated and both were strongly associated with seed yield. Thus, NHI might be useful as a selection criterion to improve seed yield in grain legumes.

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Sharara-Chami, Rana, Zavi Lakissian, Randa Farha, Hani Tamim i Nicholas Batley. "In-situ simulation-based intervention for enhancing teamwork in the emergency department". BMJ Simulation and Technology Enhanced Learning 6, nr 3 (19.08.2019): 175–77. http://dx.doi.org/10.1136/bmjstel-2019-000473.

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Simulation-based learning activities in the emergency department (ED) improve communication and teamwork and familiarise personnel with existing protocols. The authors’ objective was to develop standardised in-situ simulations and to assess their effects on team performance during simulated patient care. The study was a prospective, single-centre pre-in-situ and post-in-situ simulation-based intervention in the ED of an academic hospital between March 2017 and February 2018. Teams of three to five participants (n=46) were in two simulation interventions 2 weeks apart; each simulation was followed by debriefing with good judgement. The adapted Simulation Team Assessment Tool (STAT) Score was the primary measure for team performance. Skills are measured on a scale of 2–0 based on the complete and timely performance of tasks for a total (adapted) score of 171. Overall STAT scores improved significantly between simulations I (60.5 (28.3)) and II (81.1 (24.6)), p=029; notably in airway and teamwork domains, p=022 and p=023, respectively. A sub-analysis showed that participants performed significantly better when treating adult versus paediatric simulated patients (87.9 (20.1)), p=003, particularly in teamwork, p=01. The study yielded statistically significant improvement in clinical management, teamwork and resource management skills among ED personnel.

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CarrÃ©, Typhanie, Caroline Gaudy-Marqueste, Frédérique Albarel, Sandrine Monestier, Stéphanie Mallet, Thierry Brue, Marie-Aleth Richard i Jean Jacques Grob. "Ipilimumab-induced hypophysitis in melanoma patients." Journal of Clinical Oncology 30, nr 15_suppl (20.05.2012): 8568. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.8568.

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8568 Background: Ipilimumab (Ipi) is a human monoclonal antibody directed against cytotoxic T-lymphocyte antigene-4 (CTLA-4) recently approved for the treatment of metastatic melanoma (MM) and currently under investigation in the adjuvant setting. Methods: Retrospective analysis of patients treated with ipi between June 2006 and September 2011 in our department in Marseille. As some patients are still blinded in trials, the exact number of patient under ipi is unknown. We present a minimal percentage (>%) assuming that the 120 patients received ipi. Results: A total of 120 patients were treated: 76 stages IV MM, from which 16 in the BMS clinical trials (CA184-022, -024, and-025 and MDX 010-20) and 44 stages III MM (in the BMS CA184-029 trial). Stage IV MM were administered 0.3, 3 or 10mg/kg IV dosage, while stages III MM were randomly assigned to receive 10 mg/ kg or placebo (1:1 ratio). Hypophysitis was diagnosed in 12 patients (>10%): 2/76 patients with stage IV MM (>2. 6 %) and 10/44 patients with stage III MM (>22.7). Diagnosis was performed at the 1st, 3rd and 4th administration in respectively 2 (1.6%), 6 (50%) and 4 patients (33.3%). Clinical symptoms included headaches (n=11; 91.6%), asthenia (n=7; 58.3%) and decreased libido (n=2; 1.6%). Adrenal, thyroidal and gonadal axis were affected in respectively 6 (50%), 9 (75%) and 7 patients (58.3%). MRI changes were observed in 7 patients (58.3%): pituitary swelling in 5 patients (41.6%) and heterogeneous enhancement in 4 patients (33.3%) including 2 patients with normal biology. Corticosteroids supplementation was required in 11 patients and thyroidian supplementation in 4 patients. Clinical symptoms regressed within one week in 8 patients (66.6%). Conclusions: Ipi-induced hypophysitis is detectable only if clinicians are aware of these unspecific signs. Only MRI can make diagnosis in some patients without clinical and/or biological signs. Our data suggest that it develops especially for 10mg/kg dosage, after the third administration, and that the rate could be higher in patients with a normal immune system (adjuvant treatment), than in metastatic ones. Hormonal supplementation usually controls the disease.

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Dueñas-González, Alfonso, Juan J. Zarbá, Firuza Patel, Juan C. Alcedo, Semir Beslija, Luis Casanova, Pittayapoom Pattaranutaporn i in. "Phase III, Open-Label, Randomized Study Comparing Concurrent Gemcitabine Plus Cisplatin and Radiation Followed by Adjuvant Gemcitabine and Cisplatin Versus Concurrent Cisplatin and Radiation in Patients With Stage IIB to IVA Carcinoma of the Cervix". Journal of Clinical Oncology 29, nr 13 (1.05.2011): 1678–85. http://dx.doi.org/10.1200/jco.2009.25.9663.

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Purpose To determine whether addition of gemcitabine to concurrent cisplatin chemoradiotherapy and as adjuvant chemotherapy with cisplatin improves progression-free survival (PFS) at 3 years compared with current standard of care in locally advanced cervical cancer. Patients and Methods Eligible chemotherapy- and radiotherapy-naive patients with stage IIB to IVA disease and Karnofsky performance score ≥ 70 were randomly assigned to arm A (cisplatin 40 mg/m2 and gemcitabine 125 mg/m2 weekly for 6 weeks with concurrent external-beam radiotherapy [XRT] 50.4 Gy in 28 fractions, followed by brachytherapy [BCT] 30 to 35 Gy in 96 hours, and then two adjuvant 21-day cycles of cisplatin, 50 mg/m2 on day 1, plus gemcitabine, 1,000 mg/m2 on days 1 and 8) or to arm B (cisplatin and concurrent XRT followed by BCT only; dosing same as for arm A). Results Between May 2002 and March 2004, 515 patients were enrolled (arm A, n = 259; arm B, n = 256). PFS at 3 years was significantly improved in arm A versus arm B (74.4% v 65.0%, respectively; P = .029), as were overall PFS (log-rank P = .0227; hazard ratio [HR], 0.68; 95% CI, 0.49 to 0.95), overall survival (log-rank P = .0224; HR, 0.68; 95% CI, 0.49 to 0.95), and time to progressive disease (log-rank P = .0012; HR, 0.54; 95% CI, 0.37 to 0.79). Grade 3 and 4 toxicities were more frequent in arm A than in arm B (86.5% v 46.3%, respectively; P < .001), including two deaths possibly related to treatment toxicity in arm A. Conclusion Gemcitabine plus cisplatin chemoradiotherapy followed by BCT and adjuvant gemcitabine/cisplatin chemotherapy improved survival outcomes with increased but clinically manageable toxicity when compared with standard treatment.

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Labbé, Annie-Claude, Louise Poirier, Duncan MacCannell, Thomas Louie, Michel Savoie, Claire Béliveau, Michel Laverdière i Jacques Pépin. "Clostridium difficile Infections in a Canadian Tertiary Care Hospital before and during a Regional Epidemic Associated with the BI/NAP1/027 Strain". Antimicrobial Agents and Chemotherapy 52, nr 9 (23.06.2008): 3180–87. http://dx.doi.org/10.1128/aac.00146-08.

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ABSTRACT Since 2002, an epidemic of Clostridium difficile infections has occurred in southern Quebec, Canada. At Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada, the incidence of C. difficile infections increased from 11/1,000 admissions (1999 to 2002) to 27/1,000 admissions (2003 to 2005). We compared the exposures and outcomes for patients infected with strains with different ribopatterns isolated before (n = 55) and during (n = 175) the epidemic, as well as the in vitro activities of antibiotics against those isolates. During the preepidemic period, 46 isolates (84%) were of ribotype 001, 1 was of ribotype 027, and 8 were of other ribopattern types. During the epidemic period, ribotype 027 strains accounted for 140 (80%) isolates; 26 (15%) were of ribotype 001, and 7 were of other ribopattern types. Ribotype 027 strains were highly resistant to fluoroquinolones (FQs) but were susceptible to clindamycin. A pattern of prior specific antibiotic exposure that selected for antibiotic-resistant ribotype C. difficile infections was observed for FQs (ribotype 027) and clindamycin (ribotype 001). The rate of mortality was higher among older patients, those with a high Charlson comorbidity index, and those with longer previous hospitalizations. By multivariate analysis, patients infected with ribotype 027 were twice as likely to die within 30 days of diagnosis than patients infected with other ribotypes (adjusted odds ratio, 2.06; 95% confidence interval, 1.00 to 4.22). The observations from this study support the notion that continued selective antibiotic pressure resulted in the superimposition of the hypertoxigenic ribotype 027 clone on top of the prior dominant ribotype 001 clone in a setting of preexisting high endemicity, thus leading to the high rates of morbidity and mortality seen in the Quebec outbreak. Stringent antibiotic stewardship measures, combined with aggressive infection control, are required to curtail the epidemic of C. difficile infections.

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Urke, Helga Bjørnøy, Maurice B. Mittelmark i Martín Valdivia. "Trends in stunting and overweight in Peruvian pre-schoolers from 1991 to 2011: findings from the Demographic and Health Surveys". Public Health Nutrition 17, nr 11 (14.03.2014): 2407–18. http://dx.doi.org/10.1017/s1368980014000275.

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AbstractObjectiveTo examine trends in stunting and overweight in Peruvian children, using 2006 WHO Multicentre Growth Reference Study criteria.DesignTrend analyses using nationally representative cross-sectional surveys from Demographic and Health Surveys (1991–2011). We performed logistic regression analyses of stunting and overweight trends in sociodemographic groups (sex, age, urban–rural residence, region, maternal education and household wealth), adjusted for sampling design effects (strata, clusters and sampling weights).SettingPeru.SubjectsChildren aged 0–59 months surveyed in 1991–92 (n 7999), 1996 (n 14 877), 2000 (n 11 754), 2007–08 (n 8232) and 2011 (n 8186).ResultsChild stunting declined (F(1, 5149) = 174·8, P ≤ 0·00) and child overweight was stable in the period 1991–2011 (F(1, 5147) = 0·4, P ≤ 0·54). Over the study period, levels of stunting were highest in rural compared with urban areas, the Andean and Amazon regions compared with the Coast, among children of low-educated mothers and among children living in households in the poorest wealth quintile. The trend in overweight rose among males in coastal areas (F(1, 2250) = 4·779, P ≤ 0·029) and among males in the richest wealth quintile (F(1, 1730) = 5·458, P ≤ 0·020).ConclusionsThe 2011 levels of stunting and overweight were eight times and three and a half times higher, respectively, than the expected levels from the 2006 WHO growth standards. The trend over the study period in stunting declined in most sociodemographic subgroups. The trend in overweight was stable in most sociodemographic subgroups.

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Askling, J., E. Baecklund, F. Granath, P. Geborek, M. Fored, C. Backlin, L. Bertilsson i in. "Anti-tumour necrosis factor therapy in rheumatoid arthritis and risk of malignant lymphomas: relative risks and time trends in the Swedish Biologics Register". Annals of the Rheumatic Diseases 68, nr 5 (8.05.2008): 648–53. http://dx.doi.org/10.1136/ard.2007.085852.

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Background:Tumour necrosis factor (TNF) antagonists have proved effective as treatment against rheumatoid arthritis (RA), but the unresolved issue of whether the use of anti-TNF therapy increases the already elevated risk of lymphoma in RA remains a concern.Methods:Using the Swedish Biologics Register (ARTIS), the Swedish Cancer Register, pre-existing RA cohorts and cross-linkage with other national health and census registers, a national RA cohort (n = 67 743) was assembled and patients who started anti-TNF therapy between 1998 and July 2006 (n = 6604) were identified. A general population comparator (n = 471 024) was also assembled and the incidence of lymphomas from 1999 to 31 December 2006 was assessed and compared in these individuals.Results:Among the 6604 anti-TNF-treated RA patients, 26 malignant lymphomas were observed during 26 981 person-years of follow-up, which corresponded to a relative risk (RR) of 1.35 (95% CI 0.82 to 2.11) versus anti-TNF-naive RA patients (336 lymphomas during 365 026 person-years) and 2.72 (95% CI 1.82 to 4.08) versus the general population comparator (1568 lymphomas during 3 355 849 person-years). RA patients starting anti-TNF therapy in 1998–2001 accounted for the entire increase in lymphoma risk versus the two comparators. By contrast, RR did not vary significantly by time since start of first treatment or with the accumulated duration of treatment, nor with the type of anti-TNF agent.Conclusion:Overall and as used in routine care against RA, TNF antagonists are not associated with any major further increase in the already elevated lymphoma occurrence in RA. Changes in the selection of patients for treatment may influence the observed risk.

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Baca-Garcia, Enrique, Maria M. Perez-Rodriguez, Ignacio Basurte-Villamor, Antonio L. Fernandez Del Moral, Miguel A. Jimenez-Arriero, Jose L. Gonzalez De Rivera, Jeronimo Saiz-Ruiz i Maria A. Oquendo. "Diagnostic stability of psychiatric disorders in clinical practice". British Journal of Psychiatry 190, nr 3 (marzec 2007): 210–16. http://dx.doi.org/10.1192/bjp.bp.106.024026.

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BackgroundPsychiatric disorders are among the top causes worldwide of disease burden and disability. A major criterion for validating diagnoses is stability over time.AimsTo evaluate the long-term stability of the most prevalent psychiatric diagnoses in a variety of clinical settings.MethodA total of 34 368 patients received psychiatric care in the catchment area of one Spanish hospital (1992–2004). This study is based on 10 025 adult patients who were assessed on at least ten occasions (360 899 psychiatric consultations) in three settings: in-patient unit, 2000–2004 (n=546); psychiatric emergency room, 2000–2004 (n=1408); and out-patient psychiatric facilities, 1992–2004 (n=10 016). Prospective consistency, retrospective consistency and the proportion of patients who received each diagnosis in at least 75% of the evaluations were calculated for each diagnosis in each setting and across settings.ResultsThe temporal consistency of mental disorders was poor, ranging from 29% for specific personality disorders to 70% for schizophrenia, with stability greatest for in-patient diagnoses and least for out-patient diagnoses.ConclusionsThe findings are an indictment of our current psychiatric diagnostic practice.

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Baikov, Yury A., Nikolai I. Petrov, Margorita I. Timoshina i Evgeniy V. Akimov. "Модель микрокристаллизации 50 % двухкомпонентных металлических расплавов в диффузионно-релаксационном режиме". Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 21, nr 1 (5.03.2019): 4–15. http://dx.doi.org/10.17308/kcmf.2019.21/711.

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Рассмотрена модель микрокристаллизации 50% двухкомпонентных металлических расплавов в диффузионно-релаксационном режиме. При этом развита модель переходной двухфазной зоны (ПДЗ) в пространстве концентраций мономеров роста, принадлежащих двум агрегатным состояниям – расплаву и кристаллу. Записаны кинетические дифференциально-разностные уравнения, описывающие эволюцию структуры ПДЗ во времени с учетом ее «ступенчатой» формы, образованной механизмом спонтанных флуктуаций с ограниченным спектром изменения концентраций мономеров роста (в модели ПДЗ) во всех монослоях переходной конечной области, отделяющей собой двухкомпонентный расплав от кристаллической фазы. Учтены зависимости частот обмена мономерами роста между расплавом и кристаллом от энергий связи двух ближайших мономеров и от температуры кристаллизующейся системы расплав-кристалл. Эта модель соответствует схеме реальной конечной протяженности поверхности раздела двух соприкасающихся фаз и носит название кристалла Косселя-Странского. ЛИТЕРАТУРА Baikov Yu. A., Petrov N. I. Russian Physics Journal, 2014, vol. 57, no. 4, pp. 459-468. https://doi.org/10.1007/s11182-014-0262-2 Baikov Yu. A., Petrov N. I. Russian Physics Journal, 2014, vol. 57, 5, pp. 598-614. https://doi.org/10.1007/s11182-014-0282-y Baikov Yu. A., Petrov N. I. Russian Physics Journal, 2014, vol. 57, no. 4, pp. 459-468. https://doi.org/10.1007/s11182-014-0262-2 Baikov Yu. A., Petrov N. I. Russian Physics Journal, 2014, vol. 57, no. 5, pp. 598-614. https://doi.org/10.1007/s11182-014-0282-y Baikov Yu. A., Petrov N. I. Vestnik of MGOU, ser. "Physics and Mathematics", 2014, no. 2, p. 63. URL: https://www.vestnik-mgou.ru/Articles/Doc/7435 (in Russ.) Petrov N. I. The Crystal Disordering Study When Growing From the Binary Metallic Melts. National University of Science and Technology «MISiS» Dis. Cand. Phys. - Mat. Sci. Moscow, 2017, 180 p. URL: http://misis.ru/files/6902/Petrov_AR.pdf (in Russ.) Sarkisov P. D., Baikov Yu. A., Meshalkin V. P. The One – and Binary Metallic Melts Mathematical Modeling Crystallization. Moscow, Physmatlit Publ., 2003, 378 p. URL: https://istina.msu.ru/publications/book/101828661/ (in Russ.) Sarkisov P. D., Baikov Yu. A., Meshalkin V. P. Collection of Works. “The Optimization of Composition, Structure and Properties of Metals, Oxides, Composites, Nano – and Amorphous Materials”, Russia-Israel Conference, Moscow – Yekaterinburg, 2002, p. 172. URL: https://istina.msu.ru/publications/article/103469568/ Sarkisov P. D., Meshalkin V. P., Baikov Yu. A. Collection of Works. “The Optimization of Composition, Structure and Properties of Metals, Oxides, Composites, Nano – and Amorphous Materials”, Russia-Israel Conference, Moscow – Yekaterinburg, 2002, 184. URL: https://istina.msu.ru/publications/article/103469593/ Sarkisov P. D., Baikov Yu. A., Meshalkin V. P. Doklady Physics, 2003, vol. 48, 6, pp. 290-295. https://doi.org/10.1134/1.1591316 Baikov Yu. A., Chistyakov Yu. D. News of USSR Academy of Sciences, ser. Metals, 1990, no. 4, p. 53. (in Russ.) Baikov Yu. A., Chistyakov Yu. D. News of USSR Academy of Sciences, ser. Metals, 1991, no. 3, p. 62. (in Russ.) Baikov Yu. A., Zelenev Yu. V., Haubenreisser W., Pfeiffer H. Stat. Solidi (a), 1980, Bd. 61, no. 2, p. 435. https://doi.org/10.1002/pssa.2210610214 Chistyakov Yu. D., Baikov Yu. A., Schneider H. G., Ruth V. Crystal Research and Technology, 1985, vol. 20, no. 8, p. 1007. https://doi.org/10.1002/crat.2170200802 Chistyakov Yu. D., Baikov Yu. A., Schneider H. G., Ruth V. Crystal Research and Technology, 1985, vol. 20, no. 9, p. 1149. https://doi.org/10.1002/crat.2170200903 Schneider H. G. Collection: Advances in Epitaxy and Endotaxy. Akademiai Kiado, Budapest, 1976, p. 23

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Mazidi, Mohsen, Andre Pascal Kengne i Hassan Vatanparast. "Association of dietary patterns of American adults with bone mineral density and fracture". Public Health Nutrition 21, nr 13 (21.05.2018): 2417–23. http://dx.doi.org/10.1017/s1368980018000939.

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AbstractObjectiveIn a representative sample of US adults, we investigated the associations of nutrient patterns (NP) with bone mineral density (BMD) and fractures.DesignCross-sectional.SettingUS community-based National Health and Nutrition Examination Survey (NHANES).SubjectsParticipants with measured data on dietary intake and BMD from 2005 to 2010 were included. Principal components analysis was used to identify NP. BMD was measured using dual-energy X-ray absorptiometry. ANCOVA, adjusted logistic and linear regression models were employed, accounting for the complex survey design and sample weights.ResultsWe included a total of 18 318 participants, with 47·0 % (n 8607) being men. The mean age was 45·8 years with no sex difference. Three NP emerged, explaining 55·9 % of the variance in nutrient consumption. Multivariable-adjusted linear regressions revealed significant inverse associations between the ‘high-energy’ NP (rich in carbohydrates and sugar, total fat and saturated fat) and total femur, femoral neck, trochanter and intertrochanter BMD (β coefficient: −0·029, −0·025, −0·034 and −0·021, respectively, all P<0·001), while there were significant associations between the ‘nutrient-dense’ NP (rich in vitamins, minerals and fibre) and ‘healthy fat’ NP (high dietary PUFA and MUFA) and BMD at total femur, femoral neck, trochanter and intertrochanter (all P<0·001). In adjusted logistic regression models, the odds of hip, wrist or spine fractures did not vary significantly across NP quartiles.ConclusionsNutrient-dense and healthy fat NP are associated with higher BMD at various bone sites, while the high-energy NP is inversely associated with BMD measures.

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Jeong, Hyehyun, Yong Sang Hong, Young-Hoon Kim, Chan Wook Kim, Si Yeol Song, Joon Seon Song, Kyung-Ja Cho, Jeong Eun Kim i Jin-Hee Ahn. "The Role and Clinical Effectiveness of Multiline Chemotherapy in Advanced Desmoplastic Small Round Cell Tumor". Clinical Medicine Insights: Oncology 15 (styczeń 2021): 117955492098710. http://dx.doi.org/10.1177/1179554920987107.

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Background: A multimodal approach is the standard treatment for desmoplastic small round cell tumor (DSRCT); however, many patients are diagnosed with inoperable disease, which leaves chemotherapy as the only treatment option. There are limited data on the effectiveness of palliative chemotherapy, especially when used after first-line treatment. Here, we evaluated the clinical outcomes of patients with DSRCT treated with multiple lines of chemotherapy. Methods: We reviewed medical records of 14 patients with pathologically confirmed DSRCT at Asan Medical Center between 2004 and 2018. Results: The median age at diagnosis was 25, with males comprising 92.9% of patients. All patients had inoperable disease at presentation and received chemotherapy as the initial treatment. Four patients (28.6%) were treated with surgery, and complete resection was achieved in 1 patient. Median overall survival (OS) was 23.9 months, and 1-, 2-, and 3-year survival rates were 92.9%, 48.6%, and 19.5%, respectively. In patients receiving first- (N = 14), second- (N = 10), and third-line (N = 8) chemotherapy, median time-to-progression was 9.9, 3.5, and 2.5 months, respectively, and the disease control rates were 100%, 88.9%, and 75.0%, respectively. Factors associated with longer OS in the univariable analysis were ⩽2 metastatic sites at presentation (27.0 vs 14.7 months; P = .024) and surgery with intended complete resection (43.5 vs 20.1 months; P = .027). Conclusions: Although advanced DSRCT may initially respond to chemotherapy after first-line treatment, the response becomes less durable as the disease progresses. Individualized treatment decisions focused on palliation should be made.

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Guerra-Guzman, Karina E., Dominique R. Ghirardi i Anthony LoGalbo. "59 Effects of Cognitive Impairment, Geriatric Depression, and Anxiety on the Texas Functional Living Scale (TFLS) in a Memory Disorder Clinic". Journal of the International Neuropsychological Society 29, s1 (listopad 2023): 569–70. http://dx.doi.org/10.1017/s1355617723007300.

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Objective:The Texas Functional Living Scale (TFLS) is a measure of adaptive functioning commonly utilized across the geriatric population. Current research suggests that those with Alzheimer’s disease and other dementias perform poorly on the TFLS, compared to those with mild cognitive impairment (MCI) and normal cognition (Cullum et al., 2001). Additional research is needed to examine the influence anxiety and depressive symptoms have on activities of daily living (ADLS) in individuals being evaluated for memory disorders. This study will examine the effects of anxiety and depression on adaptive functioning across all patients, and within samples of those with dementia and MCI. It is hypothesized that higher reported anxiety and depressive symptoms will predict lower scores of ADLS.Participants and Methods:Patients at a memory disorder clinic (N = 756; 58.2% female) were screened for cognitive impairment using the Montreal Cognitive Assessment (MoCA). A brief neuropsychological evaluation (BNE) was then conducted in which the TFLS, Geriatric Depression Scale (GDS), and Geriatric Anxiety Inventory (GAI) were administered, among other measures.Results:A stepwise hierarchical regression was conducted on the entire sample to examine the effects of anxiety and depressive symptoms on TFLS performance, controlling for cognitive impairment using the MoCA. Lower MoCA scores explained a significant amount of variance in TFLS performance (R2 = 0.456, F(1, 754) = 632.78, p < .001). MoCA scores (b = 1.27, p < .001), the GAI (b = 0.14, p = .019), and the GDS (b = 0.10, p = 0.039) were significant predictors of poor TFLS performance across the entire sample. Although the MoCA, GDS, and GAI were each significant predictors of the TFLS, the increased variance explained by the GDS and GAI individually was incremental (AR2 = 0.003, F(1, 752) = 3.90, p = .049). Stepwise hierarchical regressions were also conducted on subsamples diagnosed with MCI (N = 171) and dementia (N = 394). For those with MCI, MoCA scores explained a significant amount of variance in TFLS performance (R2 = 0.044, F(1, 169) = 7.80, p = .006). Neither the GAI nor GDS explained significant additional variance. Only MoCA scores (b = .30, p =.006) predicted TFLS performance. For those with dementia, MoCA scores explained significant variance in TFLS scores (R2 = 0.338, F(1, 392) = 200.47, p < .001). The GAI explained additional significant variance when added (AR2 = 0.009, F(1, 391) = 5.26, p = .022). The GDS did not explain any additional variance. Both the MoCA (b = 1.29, p < .001) and the GAI (b = -0.15, p = .002) significantly predicted TFLS performance.Conclusions:While results suggest that anxiety and depressive symptoms alone do not explain a significant degree of variance within scores of adaptive functioning across the entire sample, elevated ratings of anxiety and depressive symptoms were significant predictors of lower scores of ADLS, suggesting some support for our hypothesis. Additionally, anxiety symptoms significantly explained increased variance in TFLS scores for those diagnosed with dementia, suggesting a potential relationship between anxiety levels and poor adaptive functioning for dementia patients.

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Navada, Shyamala C., Lewis R. Silverman, Katherine P. Hearn, Rosalie Odchimar-Reissig, Erin P. Demakos, Yesid Alvarado, Naval Daver i in. "A Phase II Study of the Combination of Oral Rigosertib and Azacitidine in Patients with Myelodysplastic Syndromes (MDS)". Blood 126, nr 23 (3.12.2015): 910. http://dx.doi.org/10.1182/blood.v126.23.910.910.

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Background: Rigosertib (RIG) is a Ras-mimetic that inhibits the PI3K and PLK cellular signaling pathways by binding directly to the Ras-binding Domain found in Ras effector proteins. It has been tested as a single agent in patients (pts) after failure of hypomethylating agents (HMAs). In vitro, the combination of RIG with azacitidine (AZA) inhibits growth and induces apoptosis of leukemic cells in a sequence-dependent fashion (RIG administered prior to AZA) (Skidan et al 2006). Phase I results of this study in pts with MDS or AML showed combination of oral RIG and standard-dose AZA to be well-tolerated with evidence of efficacy (Navada et al, Blood 2014). Phase II was initiated to further study the combination in pts with MDS. Methods: Results from pts in Phase II with MDS previously untreated with an HMA, or who had failed to respond to or progressed on a prior HMA, are presented, while response data from Phase I MDS pts are updated. Pts with CMML are analyzed separately. Oral RIG was administered twice daily on Day 1-21 of a 28-day cycle at the recommended Phase II dose (RPTD: 560 mg qAM and 280 mg qPM). AZA 75 mg/m2/d SC or IV was administered for 7 days starting on Day 8. A CBC was performed weekly and a bone marrow aspirate and/or biopsy was performed at baseline, day 29, and then every 8 weeks thereafter. Results: The combination of oral RIG and AZA has been administered to a total of 45 pts within Phase I (N=18) and Phase II (N=27). Pts were classified into the following MDS risk categories per the IPSS (Greenberg et al, Blood 1997): intermediate-1 (4), intermediate-2 (10), high-risk (14), and IPSS classification pending (4). Five pts had CMML and 8 had AML. Median age was 66 years; 69% of pts were male; and ECOG performance status was 0, 1, and 2 in 27%, 67%, and 6%, respectively. Twelve pts [MDS (9), CMML (3)] received prior HMA therapy: AZA (11 pts), decitabine (1 pts). Patients have received 1-21+ cycles of treatment to date (median, 3 cycles), with median duration of treatment of 14 weeks. Among 15 evaluable MDS pts treated with the RPTD (1 pt in Phase I, 14 pts in Phase II), marrow responses were observed in 10: marrow CR (mCR) (8), marrow PR (mPR) (2). Responses according to IWG criteria were observed in 10 pts: complete remission (CR) (1), mCR (7), hematologic improvement (HI) (2). Table 1. Responses for MDS Patients Treated at the Recommended Phase II Dose Pt Prior HMA Best BMBL at Nadir1 IWG Response2 Hematologic Improvement 102-008 None mCR mCR Platelet 101-010 None mCR CR Erythroid & Neutrophil 101-011 None mCR mCR None 101-013 None mCR mCR Erythroid 102-010 None SD SD None 101-014 AZA PD PD None 102-011 AZA mPR HI Erythroid & Platelet 101-016 AZA SD SD None 101-017 AZA mCR mCR None 102-013 None NE NE NE 101-019 None SD SD None 101-021 None PD PD None 101-024 None mCR mCR None 101-022 AZA mCR mCR None 101-025 None mCR mCR None 101-026 AZA NE NE NE 101-027 None NE NE NE 102-016 None mPR HI Platelet 1 Silverman et al, Hematol Oncol 2014 2 IWG = International Working Group (Cheson et al, Blood 2006) NE = not evaluable BMBL = bone marrow blast Overall, in pts with MDS treated on Phase I and Phase II, marrow responses were observed in 15 out of 20 evaluable pts: mCR (13), mPR (2). Responses according to IWG 2006 criteria were observed in 14 out of 19 evaluable MDS pts: CR (2), mCR (10), HI (2). Among the 7 evaluable pts with MDS in both the Phase I and Phase II who had failed to respond or progressed on prior treatment with an HMA, 5 had a response after RIG was added: CR (1), mCR (3), HI (1). Analyzed as a separate subgroup, 2 out of 5 (40%) pts with CMML had a mCR. The most frequent adverse events (AEs) in Cycle 1 included nausea (21%) and fatigue (15%), which were also the most frequent AEs in all cycles (fatigue, 28%; nausea, 26%). Six deaths have been observed so far. Three pts were treated for more than 1 year and continue on study. Conclusions: The combination oforalrigosertib and standard-dose AZA was well tolerated in repetitive cycles in pts with MDS. Marrow CR was observed in 65% of pts, both with de novo MDS and after failure of prior HMA therapy. In pts who received the RPTD, 67% of pts with MDS had a bone marrow blast and IWG response. These results suggest potential synergistic interaction of the combination and support continued study of this unique combination in patients with MDS. Disclosures Silverman: Onconova Therapeutics Inc: Honoraria, Patents & Royalties: co-patent holder on combination of rigosertib and azacitdine, Research Funding. Daver:ImmunoGen: Other: clinical trial, Research Funding. DiNardo:Novartis: Research Funding. Konopleva:Novartis: Research Funding; AbbVie: Research Funding; Stemline: Research Funding; Calithera: Research Funding; Threshold: Research Funding. Pemmaraju:Stemline: Research Funding; Incyte: Consultancy, Honoraria; Novartis: Consultancy, Honoraria, Research Funding; LFB: Consultancy, Honoraria. Fenaux:CELGENE: Honoraria, Research Funding; JANSSEN: Honoraria, Research Funding; AMGEN: Honoraria, Research Funding; NOVARTIS: Honoraria, Research Funding. Fruchtman:Onconova Therapeutics Inc: Employment. Azarnia:Onconova Therapeutics Inc: Employment.

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Mendoza, Jason A., Kathy Watson, Nga Nguyen, Ester Cerin, Tom Baranowski i Theresa A. Nicklas. "Active Commuting to School and Association With Physical Activity and Adiposity Among US Youth". Journal of Physical Activity and Health 8, nr 4 (maj 2011): 488–95. http://dx.doi.org/10.1123/jpah.8.4.488.

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Background:Walking or bicycling to school (ie, active commuting) has shown promise for improving physical activity and preventing obesity in youth. Our objectives were to examine, among US youth, whether active commuting was inversely associated with adiposity and positively associated with moderate-to-vigorous physical activity (MVPA). We also examined whether MVPA mediated the relationships between active commuting and adiposity.Methods:Using data of participants aged 12 to 19 years from the US National Health and Nutrition Examination Survey 2003 to 2004 (n = 789 unweighted), we constructed multiple linear regression models that controlled for dietary energy intake and sociodemographics. The main exposure variable was active commuting. The outcomes were BMI z-score, waist circumference, skinfolds and objectively measured MVPA. The product-of-coefficients method was used to test for mediation.Results:Active commuting was inversely associated with BMI z-score (β = −0.07, P = .046) and skinfolds (β = −0.06, P = .029), and positively associated with overall daily (β = 0.12, P = .024) and before- and after-school (β = 0.20, P < .001) MVPA. Greater before- and after-school MVPA explained part of the relationship between active commuting and waist circumference (Sobel z = −1.98, P = .048).Conclusions:Active commuting was associated with greater MVPA and lower measures of adiposity among US youth. Before- and after-school MVPA mediated the relationships between active commuting and waist circumference.

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Kerdsan, Walailuk, Samur Thanoi i Sutisa Nudmamud-Thanoi. "Changes in Glutamate/NMDA Receptor Subunit 1 Expression in Rat Brain after Acute and Subacute Exposure to Methamphetamine". Journal of Biomedicine and Biotechnology 2009 (2009): 1–4. http://dx.doi.org/10.1155/2009/329631.

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Methamphetamine (METH) is a psychostimulant drug of abuse that produces long-term behavioral changes including behavioral sensitization, tolerance, and dependence. METH has been reported to induce neurotoxic effects in several areas of the brain via the dopaminergic system. Changes of dopamine function can induce malfunction of the glutamatergic system. Therefore, the aim of the present study was to examine the effects of METH administration on the expression of glutamate N-methyl-D-aspartate receptor subunit 1 (NMDAR1) in frontal cortex, striatum, and hippocampal formation after acute and subacute exposure to METH by western blotting. Male Sprague-Dawley rats were injected intraperitoneally with a single dose of 8 mg/kg METH, 4 mg/kg/day METH for 14 days and saline in acute, subacute, and control groups, respectively. A significant increase in NMDAR1 immunoreactive protein was found in frontal cortex in the subacute group (P=.036) but not in the acute group (P=.580). Moreover, a significant increase in NMDAR1 was also observed in striatum in both acute (P=.025) and subacute groups (P=.023). However, no significant differences in NMDAR1 in hippocampal formation were observed in either acute or subacute group. The results suggest that an upregulation of NMDA receptor expression may be a consequence of glutamatergic dysfunction induced by METH.

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Clave, Emmanuel, Vanderson Rocha, Kimmo Talvensaari, Marc Busson, Corinne Douay, Marie-Lorraine Appert, Claire Rabian i in. "Prognostic value of pretransplantation host thymic function in HLA-identical sibling hematopoietic stem cell transplantation". Blood 105, nr 6 (15.03.2005): 2608–13. http://dx.doi.org/10.1182/blood-2004-04-1667.

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Abstract Thymic function is critical for immune reconstitution after hematopoietic stem cell transplantation (HSCT). We evaluated recipient thymic function before HSCT by quantifying T-cell receptor excision circles (TRECs) in pretransplantation peripheral blood lymphocytes from 102 patients who received HSCs from an HLA-identical sibling for malignant (n = 87) or nonmalignant diseases (n = 15). Median TREC value before transplantation was 257 TRECs per 150 000 CD3+ cells (range, 0-42 746). We assessed 172 TRECs per 150 000 CD3+ cells as the most discriminating TREC value for survival in a first cohort of patients (n = 62). This cut-off was validated in a second independent prospective group of 40 patients. In the 102 patients, a TREC value greater than or equal to 172 was associated with a better survival (P < .000 01), a decreased incidence of grade II-IV acute graft-versus-host disease (GVHD; P = .017), chronic GVHD (P = .023), and bacterial (P = .003) and cytomegalovirus (CMV) infection (P = .024). In a multivariate analysis, low pretransplantation TREC values were associated with a higher incidence of CMV infection (hazard ratio [HR] = 2.0, P = .06) and severe bacterial infections (HR = 2.8, P = .036). Finally, high TREC values (HR = 6.6, P = .002) and ABO compatibility (HR = 2.7, P = .02) were associated with a better survival. Therefore, recipient host thymic function assessment could be helpful in predicting HSCT outcome and identifying patients who require a close immunologic monitoring.

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Chessin, David B., i Jose G. Guillem. "Surgical Issues in Rectal Cancer: A 2004 Update". Clinical Colorectal Cancer 4, nr 4 (listopad 2004): 233–40. http://dx.doi.org/10.3816/ccc.2004.n.022.

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Vera, C. L., S. S. Malhi, J. P. Raney i Z. H. Wang. "The effect of N and P fertilization on growth, seed yield and quality of industrial hemp in the Parkland region of Saskatchewan". Canadian Journal of Plant Science 84, nr 4 (1.10.2004): 939–47. http://dx.doi.org/10.4141/p04-022.

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Industrial hemp (Cannabis sativa L.) has sparked renewed interest in western Canada in recent years, and there is very little research information available on its fertilizer requirements. The objective of this study was to determine the effect of surface-broadcast ammonium nitrate and seedrow placed monoammonium phosphate fertilizers on the production and seed quality attributes of industrial hemp (cv. Fasamo and Finola). Field experiments were conducted on a Black Chernozem silty loam soil at Melfort, Saskatchewan, Canada, in 2000, 2001 and 2002. Increasing N rates significantly increased plant height, biomass, seed yield and seed protein content of hemp in all years. Seed-applied P fertilizer increased plant height in all years, and biomass in 2000, but reduced plant density, biomass and seed yield in 2001 and 2002. Finola consistently had lower plant height, earlier maturity, heavier seeds, and higher seed yield, seed protein content and seed oil content than Fasamo. The average amount of nitrate-N in the 0–60 cm soil was 40 kg N ha-1. Seed yield kg-1 of N was 9.4, 5.9, 4.5 and 3.7 kg ha-1 for Fasamo, and 10.6, 7.7, 6.0 and 4.5 kg ha-1 for Finola, respectively, at 40, 80, 120 and 160 kg ha-1 of soil plus fertilizer N. Key words: Fertilizer, hemp, nitrogen, phosphorus, rainfall, soil extractable P, soil nitrate-N, cultivars

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Adamkiewicz, Thomas V., Miguel R. Abboud, Carole Paley, Nancy Olivieri, Melanie Kirby-Allen, Elliott Vichinsky, James F. Casella i in. "Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injury". Blood 114, nr 21 (19.11.2009): 4632–38. http://dx.doi.org/10.1182/blood-2009-02-203323.

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AbstractChronic blood transfusion is increasingly indicated in patients with sickle cell disease. Measuring resulting iron overload remains a challenge. Children without viral hepatitis enrolled in 2 trials for stroke prevention were examined for iron overload (STOP and STOP2; n = 271). Most received desferrioxamine chelation. Serum ferritin (SF) changes appeared nonlinear compared with prechelation estimated transfusion iron load (TIL) or with liver iron concentrations (LICs). Averaged correlation coefficient between SF and TIL (patients/observations, 26 of 164) was r = 0.70; between SF and LIC (patients/observations, 33 of 47) was r = 0.55. In mixed models, SF was associated with LIC (P = .006), alanine transaminase (P = .025), and weight (P = .026). Most patients with SF between 750 and 1500 ng/mL had a TIL between 25 and 100 mg/kg (72.8% ± 5.9%; patients/observations, 24 of 50) or an LIC between 2.5 and 10 mg/g dry liver weight (75% ± 0%; patients/observations, 8 of 9). Most patients with SF of 3000 ng/mL or greater had a TIL of 100 mg/kg or greater (95.3% ± 6.7%; patients/observations, 7 of 16) or an LIC of 10 mg/g dry liver weight or greater (87.7% ± 4.3%; patients/observations, 11 of 18). Although SF changes are nonlinear, levels less than 1500 ng/mL indicated mostly acceptable iron overload; levels of 3000 ng/mL or greater were specific for significant iron overload and were associated with liver injury. However, to determine accurately iron overload in patients with intermediately elevated SF levels, other methods are required. These trials are registered at www.clinicaltrials.gov as #NCT00000592 and #NCT00006182.

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Raustorp, Anders, i Andreas Fröberg. "Tracking of Pedometer-Determined Physical Activity: A 16-Year Follow-Up Study". Journal of Physical Activity and Health 15, nr 1 (1.01.2018): 7–12. http://dx.doi.org/10.1123/jpah.2017-0146.

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Background: The aims of this study were to explore the effect of time and long-termed tracking on pedometer-determined physical activity (PA) from early adolescent to the 30s. Methods: PA was measured with pedometers [Yamax™ (SW-200)] during 2000 (time 1), 2003 (time 2), 2005 (time 3), 2010 (time 4), and 2016 (time 5). Anthropometric data were collected during time 1. Data from 59 participants (n = 32 males) were analyzed from early adolescent (time 1) to the 30s (time 5). Results: There was an effect of time for males (P = .005, η2 = .76) and females (P = .002, η2 = .50) where steps per day decreased. Males steps per day tracked between time 1 and time 2 (r = .41, P = .021), time 1 and time 3 (r = .38, P = .03), time 3 and time 4 (r = .42, P = .015), and time 4 and time 5 (r = .50, P = .003). Females steps per day tracked between time 4 and time 5 (r = .39, P = .04). Males took more steps per day than females during time 1 (P = .018), whereas females took more steps per day during time 2 (P = .043) and time 3 (P = .03). Conclusion: There was a significant effect of time, where steps per day decreased between the 5 times of measurement. Steps per day tracked low to moderate in the short time span, yet tracked nonsignificantly from early adolescent to the 30s.

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Chu, Edward. "In Memoriam Paul Calabresi, MD (1930–2003)". Clinical Colorectal Cancer 3, nr 3 (listopad 2003): 138–39. http://dx.doi.org/10.3816/ccc.2003.n.020.

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Butt, Talha, Erika Lilja, Hedvig Örneholm, Jan Apelqvist, Anders Gottsäter, Magnus Eneroth i Stefan Acosta. "Amputation-Free Survival in Patients With Diabetes Mellitus and Peripheral Arterial Disease With Heel Ulcer: Open Versus Endovascular Surgery". Vascular and Endovascular Surgery 53, nr 2 (22.11.2018): 118–25. http://dx.doi.org/10.1177/1538574418813746.

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Background: Heel ulcers in patients with diabetes mellitus (DM) and peripheral arterial disease (PAD) are hard to heal. The aim of the present study was to evaluate the difference in amputation-free survival (AFS) between open and endovascular revascularization in patients with DM, PAD, and heel ulcers. Methods: Retrospective comparative study of results of open versus endovascular surgery in patients with DM, PAD, and heel ulcer presented at the multidisciplinary diabetes foot clinic between 1983 and 2013. Results: Patients with heel ulcers were treated with endovascular intervention (n = 97) and open vascular surgery (n = 30). Kaplan-Meier analysis showed that the AFS was higher in patients undergoing open vascular surgery compared to the endovascular group ( P = .009). Multivariate analysis showed that open vascular surgery versus endovascular therapy (hazard ratio 2.1, 95% confidence interval 1.1-3.9; P = .025) was an independent factor associated with higher AFS. The proportion of patients undergoing endovascular therapy in the former (1983-2000) time period was 47% compared to 89% in the latter (2001-2013) time period ( P < .001). Conclusion: The AFS was higher after open than endovascular surgery among patients with DM and PAD with heel ulcer. These results suggest that open vascular surgery should be offered more often as opposed to current practice.

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Petkus, Andrew, Xinhui Wang, Susan Resnick, Daniel Beavers, Mark Espeland, Joshua Millstein, Margaret Gatz i Jiu-Chiuan Chen. "AFFECTIVE TRAJECTORIES: RISK OF DEMENTIA AND UNDERLYING STRUCTURAL BRAIN VARIABLES IN OLDER WOMEN". Innovation in Aging 6, Supplement_1 (1.11.2022): 230. http://dx.doi.org/10.1093/geroni/igac059.913.

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Abstract Understanding how trajectories of positive and negative affect relate to dementia risk and underlying structural brain variables is important for dementia prevention. We examined associations between annually assessed Positive and Negative Affect Scale subscales and dementia risk (2000-18) among cognitively-intact community-dwelling women (N=948; aged 72.9±3.7) from the Women’s Health Initiative Study of Cognitive Aging (years 2000-2010) and Magnetic Resonance Imaging Study (2005-2006). Joint latent class mixture models were constructed to identify latent classes of women with similar trajectories of affect and dementia risk over time. Multinomial and logistic regressions examined whether structural MRI measures predicted latent class membership (adjusted for sociodemographic, lifestyle, clinical characteristics, and intracranial volume). Two latent classes of positive affect (high stable:88% and decreasing:12%) and four classes of negative affect (Minimal stable:75%; high stable:4%; emerging:12%; moderate decreasing:9%) were identified. With the high stable trajectory as referent, women with decreasing positive affect were more likely to develop dementia (HR=4.33;p<.001). The odds of being classified as this high-dementia risk group were increased among women with more (per SD) global small vessel ischemic disease (SVID;OR=1.42;p<.001), deep white matter SVID (OR=1.93;p<.001), and smaller parahippocampal volumes (OR=1.41;p=.016). For negative affect, with minimal stable negative affect as referent, women with smaller hippocampal volumes were more likely to be classified as having moderate decreasing negative affect (OR=1.45;p=.024) while emerging negative affect was associated with higher dementia risk (HR=2.00;p=.014). These findings highlight the importance of changes in affect in later-life with dementia risk and potential underlying role of cerebrovascular disease and medial temporal lobe structures.

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Davidson, Kenneth R., David W. Kribs i Miron E. Shpigel. "Isometric Dilations of Non-Commuting Finite Rank n-Tuples". Canadian Journal of Mathematics 53, nr 3 (1.06.2001): 506–45. http://dx.doi.org/10.4153/cjm-2001-022-0.

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AbstractA contractive n-tuple A = (A1,…,An) has a minimal joint isometric dilation S = (S1,…,Sn) where the Si’s are isometries with pairwise orthogonal ranges. This determines a representation of the Cuntz-Toeplitz algebra. When A acts on a finite dimensional space, the wot-closed nonself-adjoint algebra generated by S is completely described in terms of the properties of A. This provides complete unitary invariants for the corresponding representations. In addition, we show that the algebra is always hyper-reflexive. In the last section, we describe similarity invariants. In particular, an n-tuple B of d × d matrices is similar to an irreducible n-tuple A if and only if a certain finite set of polynomials vanish on B.

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Xu, Bing-e., David Lee, Aarati Ranganathan, David Gandara, Roy Herbst i Primo N. Lara. "Highlights from: The 2009 Annual Meeting of the American Society of Clinical Oncology Orlando, FL May 29-June 2, 2009". Clinical Lung Cancer 10, nr 4 (lipiec 2009): 217–22. http://dx.doi.org/10.3816/clc.2009.n.029.

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Ridwan, Nadia Syahrani, i Purnomosidi Purnomosidi. "ANALISA NON PRODUCTIVE TIME PADA PEKERJAAN PERAWATAN SUMUR N-028 PT. PERTAMINA EP CEPU". Prosiding Seminar Nasional Teknologi Energi dan Mineral 3, nr 1 (27.12.2023): 669–76. http://dx.doi.org/10.53026/sntem.v3i1.1223.

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Perawatan sumur, juga dikenal sebagai well service, adalah tindakan yang dilakukan untuk menangani semua aspek yang terkait dengan perawatan sumur minyak, dengan tujuan menjaga produksi sumur agar tetap optimal. Kegiatan ini bertujuan untuk memastikan kesiapan sumur dalam kembali berproduksi. Well service merupakan bagian yang penting dalam industri perminyakan yang terkait dengan perawatan sumur minyak dan gas. Sumur N-028 adalah sumur yang berada diwilayah kerja PT. Pertamina EP Cepu, sumur ini telah berproduksi semenjak tahun 2004. Sumur N-028 mengalami masalah produksi yaitu terjadinya penurunan laju alir produksi dikarenakan adanya masalah Kepasiran. Untuk memperlancar aliran fluida dari reservoir ke permukaan, terdapat dua tingkatan yang perlu diperhatikan. Pertama, aliran dari reservoir ke lubang sumur, dan kedua, aliran dari dasar lubang sumur ke permukaan melalui sistem mekanikal. Pada kedua tingkatan ini, aliran fluida formasi dapat terhambat oleh berbagai masalah yang mungkin terjadi di dalam reservoir maupun dalam sistem aliran. NPT yang terdapat pada sumur N-028 yaitu sebesar 264,5jam Permasalahan saat kegiatan waktu tunggu perizinan dengan total waktu 199,5jam Inspeksi/safety cheklist dengan total waktu 49,5 jam Waktu tunggu perbaikan dengan total waktu 12,5 jam Dan waktu tunggu cuaca dengan total waktu 3jam.

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Saunders, Cláudia, Maria do Carmo Leal, Paulo Augusto Ribeiro Neves, Patricia de Carvalho Padilha, Letícia Barbosa Gabriel da Silva i Arthur Orlando Corrêa Schilithz. "Determinants of gestational night blindness in pregnant women from Rio de Janeiro, Brazil". Public Health Nutrition 19, nr 5 (9.06.2015): 851–60. http://dx.doi.org/10.1017/s1368980015001846.

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AbstractObjectiveTo describe the prevalence and determinants of gestational night blindness in pregnant women receiving care in a hospital in Rio de Janeiro, Brazil.DesignCross-sectional study of pregnant and postpartum women receiving care in a public hospital in Rio de Janeiro from 1999 to 2001 (group I; n 225) or from 2005 to 2008 (group II; n 381). Night blindness was identified through a standardized and validated interview (WHO, 1996). The determinants of gestational night blindness were identified through a hierarchical logistic regression model.SettingPublic maternity hospital in Rio de Janeiro, RJ, Brazil.SubjectsAdult pregnant and postpartum women (n 606), aged ≥20 years.ResultsThe prevalence of gestational night blindness was 9·9 %. The final model revealed that not living in the South Zone of Rio de Janeiro (distal level: adjusted OR=1·846; 95 % CI 1·002, 3·401), belonging to group I (intermediate level: adjusted OR=2·183; 95 % CI 1·066, 4·471) and for the proximal level, having a history of abortion (adjusted OR=2·840; 95 % CI 1·134, 7·115) and having anaemia during the first and second trimesters of pregnancy (adjusted OR=3·776; 95 % CI 1·579, 9·029) were determinants of gestational night blindness.ConclusionGestational night blindness should be assessed for during the prenatal care of all pregnant women, especially those living in deprived areas of the city and/or who have a history of abortion or anaemia. Nutritional monitoring is recommended during pregnancy to control gestational night blindness.

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Sundermeyer, Mark L., Neal J. Meropol, André Rogatko, Hao Wang i Steven J. Cohen. "Changing Patterns of Bone and Brain Metastases in Patients with Colorectal Cancer". Clinical Colorectal Cancer 5, nr 2 (lipiec 2005): 108–13. http://dx.doi.org/10.3816/ccc.2005.n.022.

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Meyerhardt, Jeffrey A., Denise Heseltine, Shuji Ogino, Jeffrey W. Clark, Peter C. Enzinger, David P. Ryan, Craig C. Earle, Andrew X. Zhu i Charles S. Fuchs. "Efficacy of Cetuximab After Treatment with Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor—Based Chemotherapy in Metastatic Colorectal Cancer". Clinical Colorectal Cancer 6, nr 1 (maj 2006): 59–65. http://dx.doi.org/10.3816/ccc.2006.n.022.

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Chu, Edward. "The Role of a Drug Holiday: Revisited". Clinical Colorectal Cancer 6, nr 8 (lipiec 2007): 554–55. http://dx.doi.org/10.3816/ccc.2007.n.022.

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Sullivan, Catherine A. W., i Gina G. Chung. "Biomarker Validation: In Situ Analysis of Protein Expression Using Semiquantitative Immunohistochemistry-Based Techniques". Clinical Colorectal Cancer 7, nr 3 (maj 2008): 172–77. http://dx.doi.org/10.3816/ccc.2008.n.022.

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Bekaii-Saab, Tanios. "KRAS Testing in Metastatic Colorectal Cancer: Implications on the Use of Biologic Agents". Clinical Colorectal Cancer 8, nr 3 (lipiec 2009): 135–40. http://dx.doi.org/10.3816/ccc.2009.n.022.

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Holzbeierlein, Jeffrey M., Erik P. Castle i J. Brantley Thrasher. "Complications of Androgen-Deprivation Therapy for Prostate Cancer". Clinical Prostate Cancer 2, nr 3 (grudzień 2003): 147–52. http://dx.doi.org/10.3816/cgc.2003.n.022.

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Rosenberg, Jonathan E., i Eric J. Small. "Second-Line Chemotherapy for Hormone-Refractory Prostate Cancer: Has the Time Come?" Clinical Prostate Cancer 3, nr 2 (wrzesień 2004): 122–24. http://dx.doi.org/10.3816/cgc.2004.n.022.

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Link, Brian A., i Daniel J. Culkin. "Recent Trends in Surgical Treatment of Localized Prostate Cancer". Clinical Prostate Cancer 4, nr 2 (wrzesień 2005): 130–33. http://dx.doi.org/10.3816/cgc.2005.n.022.

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Ketata, Sabeur, Hafedh Ketata, Hamadi Fakhfakh, Ahmad Sahnoun, Ali Bahloul, Tahia Boudawara i Mohamed Nabil Mhiri. "Pure Primary Neuroendocrine Tumor of the Prostate: A Rare Entity". Clinical Genitourinary Cancer 5, nr 1 (czerwiec 2006): 82–84. http://dx.doi.org/10.3816/cgc.2006.n.022.

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Saad, Fred, Yin-Miao Chen, Donald M. Gleason i Joseph Chin. "Continuing Benefit of Zoledronic Acid in Preventing Skeletal Complications in Patients with Bone Metastases". Clinical Genitourinary Cancer 5, nr 6 (wrzesień 2007): 390–96. http://dx.doi.org/10.3816/cgc.2007.n.022.

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Miller, Joe, i R. Jeffrey Karnes. "Primary Clear-Cell Adenocarcinoma of the Proximal Female Urethra: Case Report and Review of the Literature". Clinical Genitourinary Cancer 6, nr 2 (wrzesień 2008): 131–33. http://dx.doi.org/10.3816/cgc.2008.n.022.

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Jafri, Mariam, i Emilo Porfiri. "A Differential Response to Sunitinib: Sustained Systemic Response Paralleled by Intra-Dural Progression in the Spine. Should Standard Response Criteria Be Reviewed?" Clinical Genitourinary Cancer 7, nr 2 (sierpień 2009): E42—E44. http://dx.doi.org/10.3816/cgc.2009.n.022.

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Savage, Clare, i Joseph B. Zwischenberger. "Image-Guided Fine Needle Aspiration Strategies for Staging of Lung Cancer". Clinical Lung Cancer 2, nr 2 (listopad 2000): 101–10. http://dx.doi.org/10.3816/clc.2000.n.022.

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Soni, Mehul K., David Cella, Gregory A. Masters, Steven P. Burch, Anne Heyes i Cheryl Silberman. "The Validity and Clinical Utility of Symptom Monitoring in Advanced Lung Cancer: A Literature Review". Clinical Lung Cancer 4, nr 3 (listopad 2002): 153–60. http://dx.doi.org/10.3816/clc.2002.n.022.

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Pirker, Robert, Katrin Wiesenberger, Gudrun Pohl i Wilma Minar. "Anemia in Lung Cancer: Clinical Impact and Management". Clinical Lung Cancer 5, nr 2 (wrzesień 2003): 90–97. http://dx.doi.org/10.3816/clc.2003.n.022.

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Bunn, Paul A. "Early-Stage Non–Small-Cell Lung Cancer: Current Perspectives in Combined-Modality Therapy". Clinical Lung Cancer 6, nr 2 (wrzesień 2004): 85–98. http://dx.doi.org/10.3816/clc.2004.n.022.

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He, Biao, Richard N. Barg, Liang You, Zhidong Xu, Noemi Reguart, Iwao Mikami, Sonny Batra, Rafael Rosell i David M. Jablons. "Wnt Signaling in Stem Cells and Non–Small-Cell Lung Cancer". Clinical Lung Cancer 7, nr 1 (lipiec 2005): 54–60. http://dx.doi.org/10.3816/clc.2005.n.022.

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Clark, Gary M., Denni M. Zborowski, Pedro Santabárbara, Keyue Ding, Marlo Whitehead, Lesley Seymour i Frances A. Shepherd. "Smoking History and Epidermal Growth Factor Receptor Expression as Predictors of Survival Benefit from Erlotinib for Patients with Non–Small-Cell Lung Cancer in the National Cancer Institute of Canada Clinical Trials Group Study BR.21". Clinical Lung Cancer 7, nr 6 (maj 2006): 389–94. http://dx.doi.org/10.3816/clc.2006.n.022.

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Radulescu, Dan, Delia Bunea, Sorin Pripon, Caius Duncea i Letitia Radulescu. "Severe Paraneoplastic Hyponatremia and Hypoosmolality in a Patient with Small-Cell Lung Carcinoma: Syndrome of Inappropriate Antidiuretic Hormone Secretion Versus Atrial Natriuretic Peptide or Both?" Clinical Lung Cancer 8, nr 6 (maj 2007): 392–95. http://dx.doi.org/10.3816/clc.2007.n.022.

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Reid, Mary E., Regina Santella i Christine B. Ambrosone. "Molecular Epidemiology to Better Predict Lung Cancer Risk". Clinical Lung Cancer 9, nr 3 (maj 2008): 149–53. http://dx.doi.org/10.3816/clc.2008.n.022.

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