Rozprawy doktorskie: „1KL”

1

Gongol, Jakub. "Návrh malého proudového motoru do 1kN tahu". Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2013. http://www.nusl.cz/ntk/nusl-230963.

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This work will be focused on issue of a jet engine. The thesis will be divided into search retrieval part and computational part. In the search retrieval part it will focus on different configurations of jet engines as well as areas of their use. The main part of the thesis will however focus on a calculations where a turbine, compressor and an exhaust nozzle will be designed in order to give a thrust of approximately 1kN. Next step will be determination of an engine charcteristic that will give us a preview on how the engine performance will look like in off-design modes.

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Carron, Christophe. "Onduleur 1kW pour roue à eau à vitesse variable /". Sion, 2006. http://doc.rero.ch/search.py?recid=8392&ln=fr.

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Reddy, Direshni. "Power management of a 1kW HTPEMFC based CHP system". Master's thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/10683.

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Includes bibliographical references (leaves 142-149).
There is a growing interest in fuel cell technology for portable, stationary and transportation applications. This is driven by the need for a greener and more fuel efficient energy generation source. Fuel cells are electrochemical energy generating devices, which require natural gas for the production of electrical and thermal power, simultaneously.

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4

Tortel, Vincent. "Conception d'un générateur d'impulsion de 1kJ pour le magnétoformage". Lille 1, 1993. http://www.theses.fr/1993LIL10035.

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Ce travail concerne le magnetoformage a niveau d'energie faible et moyenne (quelques kj), autorisant l'emploi de semi-conducteurs au silicium en place des ignitrons traditionnellement utilises. Une presentation du magnetoformage est effectuee, elle rappelle les principes, et les elements materiels utilises. Des etudes d'optimisation sont developpees, elles concernent entre autres l'absorption du champ magnetique et l'influence du compromis temps de vol duree d'impulsion, sur la vitesse de la piece a former. Il est ainsi montre qu'il suffit d'une impulsion unique (demi-periode de sinusoide) pour assurer un formage correct. Dans ce cas il sera possible d'augmenter la frequence du generateur. Celui-ci est concu avec cet objectif. Le generateur est etudie et plus principalement l'interrupteur. Differentes reflexions ont conduit a la realisation d'une structure particuliere, a partir d'association, serie/parallele, de thyristors a vitesse de croissance maximale du courant elevee (di/dt). Un prototype a ete fabrique, dans un souci de parfaite symetrie de revolution (disposition coaxiale) afin de reduire les desequilibres lies a la dispersion des semi-conducteurs et aux inductances de liaison et de connexion. Une recherche d'optimum sur la repartition des courants a initialise la conception d'elements de commande rapprochee. Un dispositif de charge du condensateur reservoir d'energie autorisant le fonctionnement a cadence elevee est developpe. Cette realisation peut servir de base pour des montages mettant en jeu une energie superieure.

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Endrizzi, J. E., i R. Sherman. "Cytogenetic Analysis of Lf Marker Gene and Monotelodisome 12L". College of Agriculture, University of Arizona (Tucson, AZ), 1986. http://hdl.handle.net/10150/219756.

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6

Halmberg, Sabina. "Beskattning av löneförmåner : förutsebarheten av vissa löneförmåners skatteplikt alternativt dess skattefrihet". Thesis, Högskolan i Jönköping, Internationella Handelshögskolan, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-15058.

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Not all payments that an employee receives are cash salary, but may also be salary benefits. It should not matter in which form an employee receives payment, taxation shall be equal despite the form of salary. Cash salary as well as salary in benefits are covered by a general rule in the Swedish Tax Law and shall therefore be taxed when they have a connection to the work performed. There are exemptions to the general rule as some benefits are tax free. In general, taxation shall be easy to foresee. The legal rules that are treated in this thesis have a general meaning. Therefore the legal rules sometimes have to be filled in or interpreted in order to clarify the meaning of them. As for the provision in 11:8 IL the meaning of it has been clarified by preambles, case law and by recommendations made by The Swedish Tax Agency. Still, the provision may not always be easy to foresee but circumstances in every specific case should make the outcome somewhat foreseeable. Benefits in the form of cars, boats and holiday houses are all benefits that fall within the general rule in 11:1 IL. For benefits in the form of cars to be taxable the car actually has to have been used. While benefits in the form of boats and holiday houses may be taxed just by being available for use. Consequently, it cannot be said that these benefits are treated in the same way. In that sense the provision is not easy to foresee. By developments in case law and by the background in the preambles different treatments of these benefits may be justified.

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Book, Stefan. "1kW Class-E solid state power amplifier for cyclotron RF-source". Thesis, Uppsala universitet, FREIA, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-341693.

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This thesis discusses the design, construction and testing of a highefficiency, 100 MHz, 1 kW, Class-E solid state power amplifier. The design was performed with the aid of computer simulations using electronic design software (ADS). The amplifier was constructed around Ampleon's BLF188XR LDMOS transistor in a single ended design. The results for 100 MHz operation show a power added efficiency of 82% at 1200 W pulsed power output. For operation at 102 MHz results show a power added efficiency of 86% at 1050 W pulsed power output. Measurements of the drain- and gate voltage waveforms provide validation of Class-E operation.

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Danyla, Deividas. "Veiksniai, įtakojantys 9 - 12kl. mokinių motyvaciją kūno kultūros pamokose, lyties aspektu". Bachelor's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140620_110624-64413.

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Darbo objektas - mokinių požiūris į motyvacija kūno kultūros pamokose. Darbo tikslas – nustatyti veiksnius, įtakojančius 9–12 kl. mokinių motyvaciją kūno kultūros pamokose. Darbo uždaviniai : 1. Nustatyti vidinio pasitenkinimo veiksnius, įtakojančius 9-12 kl. mokinių požiūrį į motyvaciją kūno kultūros pamokose, lyties aspektu. 2. Nustatyti vidinio nepasitenkinimo veiksnius, įtakojančius 9-12 kl. mokinių požiūrį į motyvaciją kūno kultūros pamokose, lyties aspektu. 3. Nustatyti išorinio pasitenkinimo veiksnius, įtakojančius 9-12 kl. mokinių požiūrį į motyvaciją kūno kultūros pamokose, lyties aspektu. 4. Nustatyti išorinio nepasitenkinimo veiksnius, įtakojančius 9-12 kl. mokinių požiūrį į motyvaciją kūno kultūros pamokose, lyties aspektu. Tiriamieji: Kauno technologijos universiteto gimnazijos, 9-12kl. mokiniai. Bendras apklaustųjų kiekis 237 mokiniai , iš kurių 122 mergaitės ir 115 berniukų. Išvados: 1. Nustatyta, kad mergaites ir berniukus stipriausiai motyvuoja tokie vidinio pasitenkinimo veiksniai kaip: gebėjimas padaryti tai, ko anksčiau nemokėjo, sėkmė ir užtikrintumas pamokų metu, gebėjimas užsiimti naujomis veiklomis, galimybė rungtyniauti ir išbandyti save, pastangos pamokų metu. 2. Vidiniai nepasitenkinimo veiksniai kurie įtakoja 9-12 kl. mergaičių ir berniukų motyvaciją kūno kultūros pamokose yra : galimybė sumažinti stresą, galimybė užsiimti mėgstama ir prasminga veikla, savirealizacijos galimybė. Lyties aspektu nustatyta , kad mergaitėms lyginant su berniukais... [toliau žr. visą tekstą]
Object of research: factors, that affect 9 – 12 grade students’ attitude to motivation in physical education classes. Aim of the study: determine the factors that affect the 9 – 12 grade students’ motivation in physical education classes. Research objectives: 1. Determine the intrinsic satisfaction factors, that affect the 9 – 12 grade students’ motivation in physical education classes, gender related aspect. 2. Determine the intrinsic dissatisfaction factors, that affect the 9 – 12 grade students’ motivation in physical education classes, gender related aspect. 3. Determine the extrinsic satisfaction factors, that affect the 9 – 12 grade students’ motivation in physical education classes, gender related aspect. 4. Determine the extrinsic dissatisfaction factors, that affect the 9 – 12 grade students’ motivation in physical education classes, gender related aspect. Participants: Kaunas University of Technology gymnasium 9 – 12 grade students’. The total amount of respondents is 237 students’, of which 122 girls and 115 boys. Conclusion: 1. It was found that girls and boys are strongly motivated by such inner satisfaction factors like: the ability to do what you did not know before, success and assurance in class, the ability to engage in new activities, the ability to emulate and test themselves and efforts at school. 2. Internal dissatisfaction factors that influence the 9 - 12 grade girls' and boys' motivation in physical education lessons are: the possibility to reduce... [to full text]

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9

Gammon, Tammy Lea. "Improved arcing-fault current models for low-voltage power systems (<1kV)". Diss., Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/15675.

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Benjelloun, Fahd. "Développement d'anticorps monoclonaux humains de type IgA dirigés contre la partie C-terminale de la protéine d'enveloppe gp41 du VIH-1". Phd thesis, Université Jean Monnet - Saint-Etienne, 2013. http://tel.archives-ouvertes.fr/tel-00999342.

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La transmission du Virus de l'Immunodéficience Humaine (VIH) par voie sexuelle représente le mode majoritaire de contamination (80%) (UNAIDS). Ce mode de contamination implique le passage du virus à travers les muqueuses et une interaction avec les cellules épithéliales et les cellules immunitaires présentes au sein de ces muqueuses (cellules dendritiques, macrophages ou lymphocytes). Les muqueuses représentent le principal site d'exposition de l'organisme aux antigènes de l'environnement. Les SIgA (IgA sécrétoires) présentes dans la lumière de ces muqueuses représentent la première ligne de défense immunitaire contre l'infection et la colonisation des muqueuses. Les IgA sont capables d'interagir avec les glycoprotéines (gp) exprimées à la surface du VIH et de bloquer l'infection et/ou la transcytose à travers l'épithélium muqueux. Nous avons pu étudier la prévalence des SIgA anti-gp41 et plus précisément anti-MPER présentes dans la salive parotidienne de personnes Exposées au VIH Séronégatives (ESN) et leur rôle dans l'inhibition de l'infection par le virus in vitro. Nous avons pu démontrer que ces sujets présentaient un taux plus important de SIgA anti-MPER neutralisantes. Ce premier travail nous a permis de valider la gp41 comme immunogène d'intérêt pour la génération de SIgA neutralisantes. Nous avons pu générer des IgA1 dans un modèle murin α1Kl chimérique capable de produire des anticorps IgA1 humanisés. L'immunisation de ces souris a permis la production de 6 anticorps monoclonaux spécifiques de la région MPER capables de reconnaître des épitopes conformationnels élargis, correspondant aux épitopes reconnus par le 2F5 et le 4E10. Les IgA1 présentaient de fortes capacités neutralisantes pour différentes souches de laboratoire et de souches primaires du VIH. Les études de caractérisation des fonctions antivirales de ces anticorps permettront de mieux définir le mode d'action de ces anticorps. A notre connaissance, ces IgA1 neutralisantes anti-MPER sont les premières décrites à ce jour dans la littérature. De par leur faible immunogénicité et leur faible autoréactivité, ces anticorps peuvent facilement être intégrés dans des approches thérapeutiques locales ou par sérothérapie passive pour la protection après administration de SHIV dans des modèles animaux comme le macaque. L'ensemble de mes travaux de thèse ont confirmé l'intérêt thérapeutique potentiel des SIgA dans la lutte contre le VIH et notamment celles dirigées contre la partie gp41 de l'enveloppe

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Luo, Ying [Verfasser]. "Chymase-Cre; Mcl-1fl/fl mice exhibit reduced numbers of mucosal mast cells / Ying Luo". Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2021. http://d-nb.info/123498508X/34.

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Cardano, M. "MSEL-1L: L'OROLOGIO MOLECOLARE DEL DIFFERENZIAMENTO NEURALE". Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/169912.

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The gene SEL-1L codifies for a protein involved in the retrotranslocation of misfolded peptides from the lumen on the endoplasmic reticulum to the cytoplasm, where they are degraded by the ubiquitin-proteasome mechanism in the ERAD (Endoplasmic Reticulum Associated Degradation) pathway. Recently, it was found that the murine protein mSEL-1L (murine SEL-1L) plays an essential role during embryonic development, since its homozygous deletion is lethal during mid-gestation, altering the correct organogenesis. This transgenic model allowed us to investigate mSEL-1L contribution in differentiation and brain development in vivo and to study its role in neural stem cell (NSC) biology in vitro, focusing on its relationship with Notch signaling. We have shown that during embryogenesis, mSEL-1L expression is ubiquitous in the developing brain with high levels detected in the ventricular regions, densely populated by neural progenitors. As development proceeds, mSEL-1L protein levels significantly decrease, allowing the detection of rare cells still expressing the protein only in the ventricular zones and in the dentate gyrus, the only adult neurogenic ¡§niches¡¨ in which a population of undifferentiated and quiescent NSCs is retained. It has been subsequently proved that mSEL-1L expression plays as essential role in directing and ensuring a harmonious NSC differentiation, as the protein deletion is associated with an early cellular differentiation that determines the progenitor pull depletion, both in vivo and in vitro. In particular, mSEL-1L absence in vivo compromises the corticogenesis, because it affects the correct sequence of neurogenic and astrogliogenic phases, altering both the residual stem cell population and its differentiated progeny. The similarity of this transgenic model with Notch mutants led us to investigate the possible involvement of mSEL-1L with this pathway. Co-immunoprecipitation analysis has revealed an interaction between these two proteins, while expression studies have shown a specific inhibition of Notch-1 signaling associated to mSEL-1L down-regulation. The expression of the nuclear activated form of the receptor, as well as that of its main effectors HES-1 and HES-5, are significantly inhibited when mSEL-1L is totally or partially depleted, promoting an erroneous up-regulation of the transcriptional factor Neurogenin-2 (NGN-2) and the following increase of the neuronal marker ƒÒIII¡VTubulin expression. The main NSC properties primarily governed by Notch pathway, such as self-renewal, differentiation, proliferation and cell survival, are drastically affected by mSEL-1L misregulation. Moreover, mSEL-1L deficient mouse models show significant vasculogenic and angiogenic defects during embryonic development, probably due to an alteration of Notch signaling. The proper control of mSEL-1L expression is therefore of paramount importance to enable the correct embryonic development, as well as its regulation during differentiation by specific and sophisticated mechanisms. In fact, it has emerged that mSEL-1L is abundantly expressed in mouse embryonic stem cells (ESCs) and is maintained stable through their in vitro differentiation into neural progenitors (NEPs) first, and then into radial glia-like NSCs, while its expression is inhibited during their final maturation into neurons, astrocytes and oligodendrocytes. So, the protein is not affected by passing from a state of pluripotency (ESCs), to multipotency (NEPs), up to tripotency (NSCs), but it must be silenced to ensure IV NSC terminal differentiation. In fact, it has been demonstrated that mSEL-1L expression is regulated in a post-transcriptional way by mmu-miR-183. This microRNA, whose expression is induced during differentiation both in vitro and in vivo, is able to negatively regulate mSEL-1L, as well as other proteins with an important function in stemness, such as ƒÒ-Integrin and Bmi-1. Differently, mmu-miR-183 down-modulation can promote an increase in the protein levels in NSCs derived from the telencephalic cortex of embryos with only one mSEL-1L functional allele (mSEL-1L HET), ensuring a high protein expression, although in presence of a reduced quantity of its messenger. In conclusion, this research has highlighted an ERAD-independent role of mSEL-1L concerning NSC biology, a role that is essential to guarantee the proper embryonic development and the homeostasis of the whole organism. Therefore, the protein appears as a sort of ¡§molecular clock¡¨ that can drive the transition from a stemness state to a differentiate one, only when it is appropriate. The data here presented may provide a good starting point for the development of specific therapeutic strategies for degenerative pathologies and for regenerative medicine applications.

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Andrianirina, Rajaonasy Gilbert. "Etude du comportement d'éléments de protection soumis à des perturbations électromagnétiques aussi rapides que 1Kv/ns". Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37602213r.

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Weber, Jean. "Caractère énamine comparé des (pyrrolidine-1 yl) et (morpholine-1yl)-3benzo (b) furanne, -thiophène et sélénophène". Metz : Université Metz, 2008. ftp://ftp.scd.univ-metz.fr/pub/Theses/1975/Weber.Jean.SMZ7501.pdf.

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15

Anscombe, William George. "Definability in Henselian fields". Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:65eec6d9-457d-4673-80de-6413865a6a46.

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We investigate definability in henselian fields. Specifically, we are interested in those sets and substructures that are existentially definable or definable with `few' parameters. Our general approach is to use various versions of henselianity to understand the `local structure' of these definable sets. The fields in which we are most interested are those of positive characteristic, for example the local fields F_q((t)), but many of our methods and results also apply to p-adic and real closed fields. In positive characteristic we have to deal with inseparable field extensions and we develop the method of Λ-closure to `translate' inseparable field extensions into separable ones. In the first part of the thesis we focus on existentially definable sets, which are projections of algebraic sets. Our main tool is the Implicit Function Theorem (for polynomials) which is equivalent to t-henselianity, by work of Prestel and Ziegler. This enables us to prove that existentially definable sets are `large' in various senses. Using the Implicit Function Theorem, we also obtain a nonuniform local elimination of the existential quantifier. The non-uniformity and local character of this result at present forms an obstacle to full quantifier-elimination. From these technical statements we can deduce characterisations of, for example, existentially definable subfields and existentially definable transcendentals. We prove that a dense, regular extension of t-henselian fields is existentially closed which, in particular, implies the old result of Ershov that F_p(t)^h ≤_Ǝ F_p((t)). Using the existential closedness of large fields in henselian fields, we are able to apply many of these results to large fields. This answers questions for imperfect large fields that were answered in the perfect case by Fehm.

In the second part of the thesis, we work with power series fields F((t)) and subsets which are F- definable (and not contained in F). We use a `hensel-like' lemma to characterise F-orbits of (singleton) elements of F((t)). It turns out that all such orbits are Ǝ-t-definable. Consequently, we may apply our earlier results about existentially definable subsets to F-definable subsets. We can use this to characterise F-definable subfields of F((t)). As a further corollary, we obtain an Ǝ-0̸-definition of F_p[[t]] in F_{p_((t)).}

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16

Gobaa, Samy. "Impact of prolamin variation and 1BL.1RS translocation on bread-making quality parameters of wheat (Triticum aestivum L.) /". Zürich : ETH, 2007. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17101.

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17

Pinheiro, Filho Ricardo Ferreira. "Estudo e implementação de uma fonte de tensão alternada de 220V/1kW alimentada por fontes CC de 24V". Florianópolis, SC, 2005. http://repositorio.ufsc.br/handle/123456789/102915.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Elétrica.
Made available in DSpace on 2013-07-16T02:19:03Z (GMT). No. of bitstreams: 1 222431.pdf: 4685463 bytes, checksum: 654ca6213d51de8a4d29437361ea3ffc (MD5)
O presente trabalho trata do projeto e implementação de uma fonte de tensão alternada alimentada por fontes de tensão CC de 24V para aplicações domésticas e embarcadas. Através deste projeto, é enfocado o estudo do acoplamento em cascata de inversores de tensão ao barramento de saída de conversores CC-CC e do seu efeito sobre a energia processada pelo conversor à montante. É apresentada uma técnica de redução da flutuação de energia observada através de uma metodologia de projeto para o filtro LC que realiza a conexão entre ambos os conversores. É apresentado um estudo completo do sistema, desde a análise topológica das estruturas escolhidas até a concepção da eletrônica auxiliar empregada na montagem, além da descrição detalhada do projeto da fonte alternada senoidal de 1kW, desenvolvida para realizar a comprovação prática dos resultados obtidos analiticamente e por meio de simulações numéricas, apresentando, por fim, o protótipo construído em laboratório e os resultados alcançados com a sua experimentação. This work presents the design and implementation of an AC voltage source fed by DC sources for domestic and mobile applications. It intends to study the coupling in cascade of voltage inverters to the DC-DC converters link and its effect on the energy processed by the upstream converter. An energy floating reduction technique that consists in a design methodology for the LC filter between both converters is presented. A complete study of the system is presented, from the chosen structures topological analysis to the conception of the used auxiliary electronics, beyond the detailed description of the 1kW AC sinusoidal source design, developed to prove practically the analytical and simulation results, presenting, finally, the developed prototype and the reached experimentation results.

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Polcyn, Adam D. (Adam Daniel) 1970. "Specific heat of Sr₃CuPt₀₅Ir₀.₅O₆ below 1K". Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/85335.

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Halbert, Andrea Sarah. "A detailed analysis of energy tax incentives in South Africa". Diss., University of Pretoria, 2016. http://hdl.handle.net/2263/60495.

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Coupled with the issue of promoting energy efficiency in South Africa is the need to focus on the source of energy production. The country's excessive burning of coal resources has been linked to the global warming crisis. To address this energy crisis, taxpayers can be encouraged to play an important role in moving the country towards a position of energy stability by conserving energy or decreasing their energy consumption, or contributing towards the research and development of energy-efficient processes as well as cleaner forms of energy. This study analyses the energy-related tax incentives that are currently legislated and available to South African taxpayers and discusses the feasibility of taking advantage of these incentives. The study may provide guidance to taxpayers that have decided to invest in renewable energy sources and will discuss some of the advantages and perceived challenges facing the renewable energy industry. This study also provides a worked example that illustrates a detailed calculation of the energy tax saving incentive set out in section 12L of the Income Tax Act, No. 58 of 1962. A case study guides taxpayers though the practical process of applying for and calculating their energy-saving tax deduction. The case study may be used as a point of reference for taxpayers planning to implement the section 12L energy efficiency tax incentive for the first time and may highlight complexities and concerns they should consider.
Mini Dissertation (MCom)--University of Pretoria, 2016.
Taxation
MCom
Unrestricted

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Näslund, Petter, i Mikael Åkesson. "Improved implementation of a 1K FFT with low power consumption". Thesis, Linköping University, Department of Electrical Engineering, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2881.

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In this master thesis, a behavioral VHDL model of a 1k Fast Fourier Transform (FFT) algorithm has been improved, first to make it synthesizable and second to obtain a low power consumption. The purpose of the thesis has not been to focus on the FFT algorithm itself or the theory behind it. Instead the aim has been to document and motivate the necessary modifications, to reach the stated requirements, and to discuss the results. The thesis is divided into sections so that the design flow closely can be followed from the initial FFT, down to the final architecture. The two major design steps covered are synthesis and power simulation. The synthesis process has been the most time consuming part of the thesis.

The synthesis tool Cadence Ambit PKS was used. Throughout the synthesis, the modifications and solutions will be discussed and comparisons are continuously made between the different solutions and the initial FFT. The best solution will then be the starting point in the next design step, which is simulation of the design with respect to power consumption. This is done by using a simulation tool from Synopsys called NanoSim. Also here, every solution is tested and compared to each other, followed by a concluding discussion. The technology used to implement the design is a 0.35um CMOS process.

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Sheen, Philip. "Dissection of the role of 1L-23 in intestinal inflammation". Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509917.

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Zarco, Hernández Jorge A. "Influencia de la translocación 1BL/1RS sobre las características aronómicas, bioquómicas y de calidad de trigo duro(triticum turgidum, L.)". Doctoral thesis, Universitat de Lleida, 1999. http://hdl.handle.net/10803/8344.

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Uno de los objetivos fundamentales de la mejora de trigo duro es la obtención de
variedades que tengan un gluten fuerte y elástico, satisfactorio para la producción de
pastas de alta calidad. Para tal fin, una estrategia es la Incorporación de material
genético de otras especies próximas al trigo duro.
En trigo harinero se han dedicado muchos esfuerzos a la obtención de genotipos con la
translocación 1BL/1R5, que se relaciona con mejores características agronómicas, tales
como resistencia a enfermedades y un mayor rendimiento. Debido a ello en el Centro
Internacional de Mejoramiento de Maíz y Trigo (CIMMYT) se ha Incorporado la
translocación 1E5L/1R5 al trigo duro. Sin embargo, la Influencia de dicha translocación en
esta especie, tanto en sus características agronómicas como en la calidad, es poco
conocida. Por ello, el siguiente trabajo se planteó con el objetivo principal de evaluar las
diferencias que presentan los trigos duros con translocación 1E3L/1RS procedentes del
cultivar Altar 04, en algunas características agronómicas, bioquímicas y de calidad.
El material vegetal que se utilizó en este trabajo fue obtenido por CIMMYT, evaluándose
ocho líneas isogénicas, cuatro de ellas con la translocación cromosómica 1E5L/1RS (1RS) y
otras cuatro sin dicha translocación (1EJS), además de incluir el progenitor Altar 04 y al
cultivar Vltrón como testigo local.
Los ensayos se realizaron en dos ambientes de México 1993-94 (uno con cinco riegos y
otro con un riego) y en cuatro ambientes de España durante los ciclos 1994-95 y 1995-
96 (Torregrossa 1994-95 y 1995-96, La Tallada 1995-96 y Jerez de la Frontera 1995-
96). Además, en el ciclo 1995-96 se realizaron tres ensayos de fertilización nitrogenada
con tres niveles de nitrógeno: Control (50 UNF/ha de N en presiembra + 6>0 UFN/ha en
encañado), Fraccionada (5O UFN/ha en presiembra + 30 UFN/ha encañado + 50 UFN/ha
en antesis) y Baja (5O UFN/ha en presiembra + 3O UFN/ha en encañado).
La evaluación agronómica de los materiales sembrados se basó en el rendimiento y sus
componentes. La Influencia de la translocación en la calidad se analizó a partir de
determinaciones relacionadas con aspectos físicos y físico-químicos del grano, -con
análisis reológicos de las masas, con observaciones sobre la elaboración y cocción del
espagueti y con una evaluación de la estructura física del gluten por microscopía de
barrido. Por último, se realizó una evaluación bioquímica de las proteínas de reserva del
grano y gluten.
Los resultados de la evaluación agronómica Indicaron que el ambiente fue el factor
determinante en la variabilidad de los parámetros medidos, for otra parte, no se
detectaron diferencias claras entre las líneas isogénicas 1RS y 155, ya que, si bien
existieron valores medios significativamente mayores en n° de espigas/m2 y n° de granos/m2en los 1155, el peso de mil granos fue significativamente mayor en los 1RS. Esto
pudo influir en que se produjera un efecto compensatorio de tal forma que no existieron
diferencias significativas en rendimiento de grano entre genotipos 155 y 1RS. Por otra
parte, no se encontró una influencia clara de la fertilización nitrogenada en el rendimiento
y sus componentes.
En las características físicas del grano, aunque en algunos parámetros se encontraron
diferencias significativas entre los genotipos 1E5S y 1RS, las magnitudes fueron pequeñas
y variaron significativamente entre los ambientes y tratamientos de fertilización
nitrogenada, por lo cual no se encontró una ventaja clara y apreciablemente grande de la
presencia del brazo 1RS en calidad física del grano de trigo duro.
En las determinaciones físico-químicas y reológicas realizadas, sólo en Intensidad del
color amarillo y cantidad de proteínas los 1RS mostraron valores mayores a los genotipos
155. En otros, como cantidad e índice de gluten, volumen de sedimentación, propiedades
de mezclado, características alveográficas y textura de masas, los genotipos 1RS
mostraron una calidad significativamente inferior en comparación a los genotipos
normales. Resultados similares se obtuvieron en la evaluación fíe la cocción del
espaguetti. Además, los niveles de calidad mostrados por los genotipos 1RS fue tal que
haría difícil su aprovechamiento en la elaboración de pastas y otros posibles productos.
La calidad Inferior de las isolíneas 1RS también se puso de manifiesto en la estructura
física del gluten, la cual se analizó en un microscopio electrónico de barrido, donde se
observó que el gluten del trigo 155 posee una estructura tridimensional apreciablemente
más compacta, cerrada y continua que la estructura de los genotipos 1RS.
La calidad inferior de los líneas Isogénlcas con translocación 1E5L/1RS (1RS) se explicó a
través de los resultados obtenidos en el análisis bioquímico de la proteínas de reserva. En
el fraccionamiento de las proteínas por SDS-PAGE y A-PAGE, mientras las líneas
Isogénlcas normales (1BS) mostraron tener las subunldades de proteínas codificadas por
el loci Glu-£>3/GI¡-&1, las líneas Isogénlcas 1RS en todo momento carecieron de éstas.
Memas, por el fraccionamiento y cuantlflcaclón de las proteínas por RP-HPLC, se
encontró que la fracción Glu LMW-6> marcó la principal diferencia cuantitativa entre
genotipos 1B5 y 1RS. Como promedio de los valores medios de los ensayos, los genotipos
1RS tuvieron 26% de las Glu LMW-& halladas en los genotipos 155.
Así pues, con base a los resultados de este trabajo se puede concluir que la calidad
inferior de los trigos duros con la translocación 1BL/1R5 fue principalmente determinada
por la carencia de las subunldades Glu LMW-B> codificadas por el locus Glu 03, las cuales
representaron un proporción Importante de las proteínas de reserva de los trigos duros
normales estudiados.

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Ikeshoji, Marco Akio. "Estudo e realização de um conversor de baixo custo para acionamento de motor de indução de baixa potencia (<1KW)". reponame:Repositório Institucional da UFSC, 1993. https://repositorio.ufsc.br/handle/123456789/111635.

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Tinubu, Olusegun Olukunle. "Effect of Friction-stir Processing on the Wear Behavior of Titanium (Ti-1Al-8V-5Fe) and Stainless Steel (A-286) Alloys". Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc801955/.

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The effect of friction stir processing (FSP) on the mechanical wear behavior was investigated for Ti-1Al-8V-5Fe (Ti-185) and stainless steel (Incoloy® A-286) alloys. The Ti-185 and A-286 alloys were tested in different processing conditions, including as rolled (AR), AR+FSP, and AR+FSP+aged. A high frequency reciprocating rig was used to simulate fretting-type wear of these alloys at room temperature. The Vickers micro-hardness and wear rates were calculated and compared for each processing condition. It was determined that along with increasing hardness in the stir zones, FSP resulted in improved wear resistance for both alloys. Specifically, wear rates in the stir zones were reduced to lowest values of 1.6 x 10-5 and 5.8 x 10-7 mm3/N·m for the AR+FSP+aged Ti-185 and A-286 alloys, respectively, despite lower hardness for A-286 alloy. Mechanistic studies were conducted to determine the reason behind these improvements in wear resistance and the effect of FSP on the microstructural evolution during wear. For the Ti-185 alloy, x-ray diffraction revealed that there was a phase transformation from β-Ti (AR+FSP) to α-Ti (AR+FSP+aged). This phase decomposition resulted in the harder and stiffer Ti phase responsible for lowering of wear rate in Ti-185. While x-ray diffraction confirmed the A-286 alloy retains its austenitic structure for all conditions, scanning electron microscopy revealed completely different wear track morphology structures. There was increased coarse abrasion (galling) with the AR+aged A-286 alloy compared to the much finer-scale abrasion with the AR+FSP+aged alloy, which was responsible for smaller and less abrasive wear debris, and hence lower wear rate. Furthermore, cross-sectional focused ion beam microscopy studies inside the stir zone of AR+FSP+aged A-286 alloy determined that a) increased micro-hardness was due to FSP-induced microscopic grain refinement, and b) the corresponding wear rate decrease was due to even finer wear-induced grain refinement. With both effects combined, the level of damage and surface fatigue wear was suppressed resulting in lowering of the wear rate. In contrast, the absence of FSP-induced grain refinement in the AR+aged A-286 alloy resulted in lower hardness and increasing wear rate. In addition, micro-Raman spectroscopy inside the stir wear zone determined that the wear debris contained metal oxides of Fe3O4, Cr2O3, and NiO, but were a consequence and not the cause of low wear. Overall, FSP of titanium and stainless steel alloys resulted in lowering of wear rates suggesting it is a viable surface engineering technique to target and mitigate site-specific wear.

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Kittner, Kristina [Verfasser], Rudolf [Gutachter] Kawalla i Heinz [Gutachter] Palkowski. "Entwicklung einer Warmwalztechnologie für Warmband einer Mg-2Zn-1Al-0,3Ca-Legierung mit hoher Umformbarkeit / Kristina Kittner ; Gutachter: Rudolf Kawalla, Heinz Palkowski". Freiberg : Technische Universität Bergakademie Freiberg, 2021. http://d-nb.info/1228540462/34.

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Parpaleix, Jean. "Modélisation de la logique à injection 12L dans le procédé à isolement par oxyde subilo N application à l'optimisation des circuits /". Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb376086704.

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McDonald, Stuart Alistair Charles. "Characterisation and immunomodulation of inflammatory bowel disease in 1L-2 knockout mice". Thesis, Queen Mary, University of London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271700.

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28

Shatkina, Liubov [Verfasser]. "Modulation of androgen receptor action by the cochaperone BAG-1L / Liubov Shatkina". Karlsruhe : KIT-Bibliothek, 2003. http://d-nb.info/119822102X/34.

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BRITO, NETO Osmundo Batista de. "Atendimento de energia elétrica domiciliar para comunidades isoladas de baixa potência do interior do estado do Pará através de um gaseificador de 1kw". Universidade Federal do Pará, 2006. http://www.repositorio.ufpa.br:8080/jspui/handle/2011/1697.

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Made available in DSpace on 2011-03-23T21:19:17Z (GMT). No. of bitstreams: 0
Item created via OAI harvest from source: http://www.bdtd.ufpa.br/tde_oai/oai2.php on 2011-03-23T21:19:17Z (GMT). Item's OAI Record identifier: oai:bdtd.ufpa.br:104
In Pará State, almost 21% of its population has no access to use of electric energy in their residence. To this universe belongs the target audience from this report, that are the isolated communities. Due the large territorial extension and hydrographic basin in Pará State, this communities will have many difficulties to be served by the extension of distribution network. The proposal of this report consists in the use of the Açaí seed as biomass to an Indian co-current and open top gasifier of 1 Kg/hour, adapted and adjusted to the specifications of this region; the gasification system is connected to a generator of 2 KVA (Diesel or Gas), to supply with electric energy for the isolated communities where already exists the biomass as a result of the Açaí seed processing that is been considered as garbage. In this context, the governmental programs were examined in order to support this proposal, using the proposed system as one of many options to serve with electric energy by alternative source.
No Pará, quase 21% de sua população, não tem acesso ao uso da energia elétrica na sua residência. Neste universo está o público alvo deste trabalho que são as comunidades isoladas. Dado a extensão territorial e a extensa bacia hidrográfica do Estado do Pará, estas comunidades dificilmente serão atendidas por extensão da rede de distribuição. A proposta deste trabalho consiste na sugestão de uso do caroço de Açaí como biomassa para um gaseificador indiano de 1 Kg/hora, co-corrente e topo aberto, adaptado e adequado às especificidades da região; o sistema de gaseificação é acoplado a um gerador de 2 KVA (Diesel ou Gasolina), para suprir com energia elétrica as comunidades isoladas, onde já existe a biomassa como resultado do processamento do Açaí e que vem sendo tratada como lixo. Neste contexto, foram pesquisados os programas governamentais que podem respaldar esta proposta, utilizando-a como uma das muitas opções de atendimento de energia elétrica através das fontes alternativas.

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Cuadros, Basis Víctor Alberto. "Diseño de un embrague mecánico para el acoplamiento del eje de una rueda hidráulica de 2m de diámetro y que trasmite 1kw de potencia". Bachelor's thesis, Pontificia Universidad Católica del Perú, 2009. http://tesis.pucp.edu.pe/repositorio/handle/123456789/572.

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Existe al presente una rueda hidráulica en la PUCP que no está siendo aprovechada eficientemente. En uno de los extremos del eje tiene una bomba que se acciona con el giro y al otro lado del eje simplemente está apoyado en una chumacera. Este proyecto inicia cuando se descubrió el potencial de elaborar un mecanismo que permitiría utilizar el giro del extremo libre para almacenar energía. Actualmente, la energía producida por ese lado del eje estaba en completo desuso y a través de esta iniciativa esta energía se podrá aprovechar y utilizar de manera eficiente. El proyecto se empleará a través de un sistema de embrague que fue diseñado con este propósito ya que se quiere acoplar un generador mientras el eje esté girando. Se efectuó un análisis físico, estático, técnico y económico, finalmente se diseñó un procedimiento que cumplió con las obligaciones propuestas. Esto se logró siguiendo los siguientes pasos: un estudio extenso del estado del arte, estudio de las funciones principales del sistema, las alternativas viables, las evaluaciones técnicas, evaluaciones económicas, cálculos, proceso de selección, esquemas representativos, finalizando con un estudio del mercado peruano. De acuerdo al reto asumido inicialmente, y después de la investigación, el diseño, la elaboración de planos y las respectivas revisiones se puede decir que se logró obtener los resultados previstos con este sistema de embrague. El embrague soportará el torque entregado por la rueda hidráulica de 1kW de potencia y 2m de diámetro sin esforzar al operario, prometiendo que el trabajo será seguro, liviano, confiable y económico. De esta manera se puede concluir que se cumplieron las metas establecidas logrando superar este desafío.
Tesis

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Kittner, Kristina [Verfasser], Rudolf [Akademischer Betreuer] Kawalla, Rudolf [Gutachter] Kawalla i Heinz [Gutachter] Palkowski. "Entwicklung einer Warmwalztechnologie für Warmband einer Mg-2Zn-1Al-0,3Ca-Legierung mit hoher Umformbarkeit / Kristina Kittner ; Gutachter: Rudolf Kawalla, Heinz Palkowski ; Betreuer: Rudolf Kawalla". Freiberg : Technische Universität Bergakademie Freiberg, 2021. http://d-nb.info/1228540462/34.

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Styer, Jean Christine. "Regulating Inositol Biosynthesis in Plants: Myo-Inositol Phosphate Synthase and Myo-Inositol Monophosphatase". Thesis, Virginia Tech, 2000. http://hdl.handle.net/10919/9870.

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Inositol is important for normal growth and development in plants. The regulation of the inositol biosynthetic enzymes, myo-inositol phosphate synthase (MIPS) and myo-inositol monophosphatase (IMP) was investigated. The specific aims of this research were (1) to develop a tool to study MIPS protein accumulation in a model plant system, Arabidopsis thaliana (At) and potentially other plant species and (2) to determine the spatial expression patterns of Lycopersicon esculentum IMP-2 (LeIMP-2) at the cellular level.

Myo-inositol phosphate synthase (mips) genes have been identified in plants, animals, fungi and bacteria. Alignment of the predicted amino acid sequences of AtMIPS-1, -2 and Glycine max MIPS (GmMIPS) indicated that AtMIPS-1 and GmMIPS are 87% identical, and AtMIPS-2 and GmMIPS are 89% identical. Based on these data, a Gmmips cDNA was fused at the N-terminus to a 6X histidine tag (5' GAC GAC GAC GAC GAC GAC 3'), cloned into an overexpression vector and overexpressed in E. coli. The fusion protein, HISMIPS, was extracted using denaturing conditions and purified using Ni²⁺ affinity chromatography. Anti-GmMIPS antiserum from rabbit detected the recombinant HISMIPS protein (76 kD), and GmMIPS (64 kD). Affinity purification by subtractive chromatography yielded anti-GmMIPS antibody that detected MIPS (66 kD) and a protein (34 kD) of unknown function. AtMIPS accumulated to high levels in unopened flowers, opened flowers, and immature siliques (6 mm in length or less), but was not detectable in bolts, cauline or rosette leaves.

The tomato inositol monophosphatase (Leimp) genes are a developmentally regulated multigene family. From analysis of sequences, Leimp-2 is intron-less and has the putative start site of translation located at +108 bp downstream from the putative start site of transcription. Investigation of the 5â UTR revealed the 3' end of a partial open reading frame (338 bp) highly homologous to the gene for calmodulin. Three light responsive elements and a cold responsive element were also identified in the 5' UTR.

Transgenic Leimp-2::uidA plants were produced using the existing construct of the Leimp-2 promoter fused to the uidA gene (J. Keddie, University of California at Berkeley). Seedlings were perserved and sectioned. Using histological techniques, the analysis of the Leimp-2 promoter::uidA transgenic seedlings revealed that the Leimp-2 promoter causes expression at the base of the shoot apex and within leaflets of the first set of fully expanded leaves. Further, Leimp-2 promoter expression was localized to epidermal and cortex cells on the abaxial side of the 1st and 2nd fully expanded compound leaves.

These studies of MIPS and IMP expression lay a foundation for a better understanding of the regulation of inositol biosynthesis in Arabidopsis, tomato, and other plant species.

Master of Science

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33

Steer, Wendy Myfanwy. "The distribution and role of nucleosome assembly protein (xNAP-1L) in Xenopus laevis development". Thesis, University of Portsmouth, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247498.

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Fuseya, Yasuhiro. "The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC". Kyoto University, 2020. http://hdl.handle.net/2433/259006.

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Santos, Fellipe Bronze dos. "Análise bioquímica e estrutural das proteínas dermicidina-1L e sua splice variante em sistema biomimético". Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-26062014-170711/.

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Dermicidina (DCD) é um gene mapeado no cromossomo 12, lócus 12q13.1, e codifica uma proteína de 110 aminoácidos, que sofre um processamento proteolítico, gerando peptídeos ativos. O peptídeo C-terminal (DCD-1L) de 48 aminoácidos tem uma carga -2, e exerce função antibacteriana e antifúngica, e o peptídeo C-terminal splice variante, denominado DCD-SV de 59 aminoácidos, tem carga neutra, e suas propriedades ainda não foram estabelecidas. Neste trabalho são apresentados os resultados da expressão, purificação e sequenciamento da DCD nativa produzida em E. coli BL21 transformada com o vetor pAE-DCD. Na segunda parte são descritas as análises físico-químicas e bioquímicas da interação dos peptídeos sintéticos DCD-1L e DCD-SV com vesículas lipídicas gigantes e vesículas unilamelar grandes sintetizadas com palmitoil-oleoil-fosfatidilcolina. As preferenciais estruturais dos peptídeos foram investigadas por espectroscopia de Dicroísmo Circular. Nossos resultados sugerem que a DCD-SV tem alta propensão para adotar uma estrutura helicoidal permitindo sua inserção e oligomerização em membranas biomiméticas, e possível formação de canais de condutância molecular.
Dermicidin (DCD) is mapped a gene on chromosome 12, locus 12q1.13 whose 110 amino acids protein is proteolytically processed to N and C-terminal peptides. The 48-amino acid C-terminal peptide (DCD-1L) has -2 net charges and display antibacterial and antifungal properties and the 59-amino acid splice variant C-terminal peptide (DCD-SV) has neutral net charge; however, its structure and biological function are unknown. Here we show the results of expression, purification and amino acid sequencing of recombinant DCD protein produced in E.coli transformed with pAE-DCD vector. We also describe the results of physical-chemical and biochemical analyses showing the visible differences between the interactions of DCD-1LL and DCD-SV synthetic peptides with giant unilamellar vesicles and large unilamellar vesciles made of palmitoyl-oleoyl phosphatidylcholine, used as biomimetic membranes. The structural preferences of peptides were analyzed by circular dichroism spectroscopy. Our results suggest that DCD-SV peptide has higher propensity to adopt helicoidal structure enabling it to insert into mimetic membranes, undergo oligomerization and formation of conductance channel.

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Ramos, Felipe Guimarães. "Desenvolvimento de uma máquina síncrona trifásica com ímãs de Nd-Fe-B e núcleo do estator a partir de Fe2%P sinterizado aplicado em aerogerador de 1kW". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/118863.

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Este trabalho tem por objetivo a utilização do núcleo de estator de uma máquina elétrica construído a partir do processo da Metalurgia do Pó utilizando a liga ferro com 2% fósforo (Fe2%P). O núcleo obtido substitui o núcleo comercial (laminado) do gerador síncrono de imãs permanentes com potência de 1kW. O gerador elétrico utilizado no trabalho é encontrado em geradores eólicos de pequeno porte. Esta máquina elétrica é um gerador com fluxo axial excitado através de imãs permanentes, sendo nomeada de Torus por utilizar um núcleo em formato toroidal. Foram realizados ensaios de rendimento do gerador em bancada com ambos os núcleos, comercial e o concebido a partir de metalurgia do pó. Com estes ensaios foi possível a comparação do desempenho da máquina com os dois núcleos. O núcleo do estator obtido pelo processo de metalurgia do pó obteve rendimentos elétricos equivalentes ao da máquina utilizando núcleo comercial, porém durante o teste em vazio o gerador com núcleo de Fe2%P apresentou uma potência mecânica de acionamento superior a máquina utilizando núcleo comercial. A máquina com núcleo comercial possui uma eficiência geral de no mínimo oito por cento superior a máquina que utiliza núcleo do estator com Fe2%P.
The purpose of this paper is to use the stator core of an electrical machine built from the Powder Metallurgy process using iron alloy with 2% (Fe 2% P). The core obtained replaces the commercial core (laminated) of the synchronous generator with permanent magnet power of 1kW. The electric generator used at work is found in small wind generators. This electric machine is a generator with an axial flow excited by permanent magnets that have been named Torus for using a core in the toroidal format. Bench Generator performance tests were conducted with both the commercial and the powder metallurgy designed cores. With these tests, a comparison between the machine’s performance and both cores was possible. The stator core obtained by the powder metallurgy process achieved an electrical performance equivalent to that of the machine using the commercial core, however, during the no load test, the generator with the Fe2% P core presented a higher mechanical power drive to that of the machine using the commercial core. The machine with a commercial core has an overall efficiency of at least eight per cent higher than that of the machine that uses the stator core with Fe2%P.

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Andreo, Vagner Caetano. "Estudo dos efeitos da injeção intravascular de drogas vasoconstrictoras, presentes nas soluções anestésicas locais, sobre a pressão arterial de ratos normotensos, hipertensos renais um-rim, um clip (1R-1C) e 1R-1C tratados com atenolol". Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/25/25142/tde-01062011-093936/.

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O presente trabalho teve como objetivo analisar e comparar o efeito de agentes vasoconstrictores presentes nas soluções anestésicas locais, injetados por via intravenosa nas doses de 80, 160, 320, 640 e 1280 ng (adrenalina) ou 0.5, 1, 2, 3 e 4 UI (felipressina), sobre a pressão arterial de ratos, hipertensos renais um-rim, um clip (1R-1C) e 1R-1C tratados com atenolol, comparando com animais nomotensos de mesmo peso e lote. Ratos Wistar machos pesando 150g, foram anestesiados com mistura de igual quantidade de quetamina e xilazina (1mL da mistura/kg), tiveram seu abdômen aberto e receberam um clip de prata com abertura 0,25mm na artéria renal esquerda, removendo-se cirurgicamente o rim direito (ratos 1R-1C). Alguns desses animais, depois de 14 dias, tiveram sua pressão sistólica indireta registrada pela pletsmografia de cauda e começaram a receber tratamento com atenolol (90 mg/kg/dia) por gavage (1R-1C tratados). Após 28 dias da implantação do clip, todos os grupos foram novamente anestesiados e implantaram-se cânulas de polietileno (PE-50) na artéria carótida esquerda e veia jugular direita, para registro direto da pressão arterial e injeção de drogas, respectivamente. Animais de mesmo lote e peso serviram como controle (normotensos). O catéter arterial foi então conectadas ao sistema de registro computadorizado (PowerLab®) utilizando software específico (Chart 5Pro ®). A pressão arterial (PA) e frequência cardíaca (FC) registradas durante os primeiros 5 minutos, foram consideradas como valores basais. Analisaram-se: a menor resposta hipotensora, maior resposta hipertensora, freqüência cardíaca média e duração da resposta, nos três grupos de animais, para cada dose injetada dos dois vasoconstrictores. Os dados foram submetidos à análise de variância de medidas repetidas (ANOVA), seguida do teste de Holm-Sidak ou de Mann-Whitney, quando apropriado, a um nível de significância de 5%. A felipressina, ao contrário da adrenalina, não apresentou ação hipotensora; por outro lado, ambas apresentaram respostas hipertensoras de magnitude semelhante nos 3 grupos de animais, notando-se tendência para menores respostas nos animais tratados com atenolol. A felipressina provocou queda de FC significativa (p<0,01) nos animais normotensos e tratados, causando aumento de FC nos hipertensos apenas com as maiores doses, enquanto que a adrenalina provocou aumento de FC dose-dependente nos normotensos e hipertensos, sem promover alteração da FC nos ratos tratados. A duração da resposta hipertensora provocada pela felipressina foi significativamente maior que a provocada pela adrenalina (p<0,01) em todos os grupos de animais, indicando possível efeito vasoconstrictor prolongado. Os resultados permitem afirmar que a felipressina apresenta ações semelhantes à adrenalina, com resposta hipertensora mais prolongada, nas populações de animais analisadas. Em função das doses e da via empregada nesse estudo, pode-se sugerir que a felipressina é bastante segura para populações hipertensas ou que estejam recebendo atenolol.
The present study was designed to analyze and compare the effects of some vasoconstrictors, injected by intravenous route in the doses of 80, 160, 320, 640 and 1280 ng (epinephrine) or 0.5, 1, 2, 3 and 4 IU (felypressin) upon the arterial pressure of normotensive, 1K-1C hypertensive and 1K-1C rats treated with atenolol. Male Wistar rats weighting 150g were anesthetized with a mixture of equal proportion of ketamine and xylazine by intraperitonial injection (1mL/kg) and 1K1C hypertension was surgically induced by means of partial constriction of the main left renal artery with a silver clip with a 0.25-mm gap. The right kidney was surgically removed. Fourteen days after surgical procedures arterial pressure (AP) was indirectly measured (tail cuff method) to monitor the development of hypertension. Only 1K1C rats with AP more than 150mm Hg were included in the protocol and received by gavage (1mL/d), for the next 14 days, atenolol (90 mg/kg/day). The treatments were carried out always between 8 and 9 AM. Four weeks after the surgical procedure all rats were anesthetized again with the same mixture and a catheter (PE50) was inserted into the left carotid artery and right jugular vein, respectively to obtain a AP register and to inject drugs. The arterial catheter was then connect to the transducer and to computer register system (PowerLab®) using a Chart 5 Pro® software. The AP and heart rate (HR) registered in the first five minutes were considered basal values. The following parameters were registered: minimal hypotensive response, maximal hypertensive response, mean HR and response lenght (duration), in all animals groups, to every injected dose of epinephrine and felypressin. The data were analyzed by two ways repeated measures ANOVA followed by Holm-Sidak or Mann-Whitney test, when appropriated. The significance level was 5%. Epinephrine, but not felypressin, presents some hypotensive action with the lowest doses. However, both of them present hypertensive responses of same magnitudes in all groups, with non-significant reduced responses noted in the 1K-1C atenolol group. The HR was significantly lowered by felypressin in the normotensive and 1K-1C atenolol group; this vasoconstrictor agent produced elevated HR in hypertensive rats only with the greatest doses. Epinephrine caused dose-dependent increases in HR in normotensive and 1K-1C without modifying the HR of 1K-1C atenolol treated rats. The felypressin response length were significantly longer than that produced by epinephrine in all groups (p<0,01), indicating a prolonged vasoconstrictor effect. Our results suggest that felypressin has equipotent pressure responses when compared with epinephrine, showing greater extent of action. Considering the administration route, the doses used in this study and the concentration in local anesthetics cartridges, we suggest that felypressin was safe enough to be one of the vasoconstrictors of choice in hypertensive subjects and in those who received atenolol as a medication to lower their pressure.

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Adèle-dit-Renseville, Nathalie. "Développement d'une technique d'analyse d'échantillons limites en quantité d'ADN adaptée aux applications médicales et médico-légales". Nantes, 2010. http://www.theses.fr/2010NANT2113.

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Paulmann, Maren [Verfasser], i Birgit [Akademischer Betreuer] Schittek. "Strukturelle Untersuchungen zum Wirkmechanismus von DCD-1L, einem anionischen antimikrobiellen Peptid / Maren Paulmann ; Betreuer: Birgit Schittek". Tübingen : Universitätsbibliothek Tübingen, 2014. http://d-nb.info/1196877645/34.

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Toan, Duong Duc. "Assessment of river discharge changes in the Indochina Peninsula region under a changing climate". 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/195976.

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Khalil, Najat. "L'activation des récepteurs activés par les proliférateurs de peroxysomes beta/delta, stimule l'expression de Siah-1L et entraîne la prolifération et la migration de cellules de glioblastomes". Thesis, Université de Lorraine, 2013. http://www.theses.fr/2013LORR0286/document.

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Les Glioblastomes représentent les tumeurs cérébrales primaires les plus fréquentes chez l'adulte. Nous avons mis en évidence le rôle du récepteur PPARß/delta dans le caractère tumoral des glioblastomes. Nous avons montré que l'activation de ce récepteur stimule la prolifération et la migration des cellules de glioblastome T98G. Nous avons également montré que l'activation de PPARß/delta induit l'expression du gène Siah-1L et que la surexpression de ce gène stimule la prolifération et la migration cellulaire des glioblastomes. Nous avons ensuite étudié la régulation du gène Siah-1L humain et montré que son expression est induite par PPARß/delta. Le clonage du promoteur de ce gène et l'étude de sa régulation a permis de montrer que son induction par PPARß/delta est médiée par un élément de réponse situé au niveau du promoteur
Glioblastoma represent the most frequent primary brain tumor in adults. We highlighted the role of PPARß/delta in glioblastoma tumorigenesis. We have shown that activation of this receptor stimulates proliferation and migration of glioblastoma cells T98G. We also showed that activation of PPARß/delta induces the expression of Siah-1L gene and that overexpression of Siah-1L stimulates cell proliferation and migration of glioblastoma cells. We also studied the regulation of Siah-1L gene and showed that its expression is induced by PPARß/delta. Cloning of Siah-1L gene promoter sequence and the study of its regulation showed that the induction of the expression of Siah-1L by PPARß/delta is mediated by a response element located at the promoter sequence

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Selwyn, Rebecca. "Improved adsorption calorimeter : studies of loose grained silica gel and silica gel-based selective water sorbent (SWS-1L)". Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.702188.

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This thesis aimed to develop a new version of an adsorption calorimeter originally proposed by Ahamat and Tierney. A more rigorous approach was taken in terms of mechanical components, vacuum equipment, calibration of thermoelectric modules, and length of tests. Novel contributions include the new temperature control algorithm, new adsorbent configuration, new adsorbent, and consideration of the effect of residual air on the kinetics of adsorption. Improved design of the hardware reduced the air ingress from 1mbar/hour to

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Daniel, Alexander [Verfasser]. "Haftmechanismen von 1K-PUR-Klebstoffen auf lackierten Oberflächen : grenzflächenchemische Untersuchungen zur Haftung und Enthaftung auf automobilen Multischicht-Lacksystemen / Alexander Daniel". Paderborn : Universitätsbibliothek, 2016. http://d-nb.info/1108389635/34.

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Sudmann, Stefan. "Untersuchung zur Modulation der Fas-Rezeptor-(Apo-1, CD95) und Fas-Ligand- (Apo-1L) -Expression beim Ösophaguskarzinom Inzidenz und prognostische Relevanz /". [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=969289820.

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Fleury, Camila de Assis. "Avaliação dos efeitos da injeção intravascular de drogas vasoconstritoras, presentes nas soluções anestésicas locais, sobre a pressão arterial e glicemia de ratos normotensos, diabéticos, hipertensos renais um-rim, um clip (1R-1C) e 1R". Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/25/25149/tde-12062012-152828/.

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O presente trabalho teve como objetivo associar modelos indutivos de diabetes e hipertensão, analisar e comparar o efeito de agentes vasoconstritores presentes nas soluções anestésicas locais, injetados por via intravenosa nas doses de 80, 160, 320, 640 e 1280ng (adrenalina) ou 0,125; 0,25; 0,5; 1; 2 e 3 x10-3UI (felipressina), sobre a pressão arterial de ratos normotensos, diabéticos, hipertensos renais um-rim, um clip (1R-1C) e hipertensos1R-1C-diabéticos, além de verificar a glicemia após injeção de doses correspondentes a 20 e 80% da resposta pressora máxima. Ratos Wistar machos pesando 110-160g, foram anestesiados com mistura de quetamina e xilazina (50+10mg/ml/kg de peso), tiveram seu abdômen aberto e receberam um clip de prata com abertura 0,25mm na artéria renal esquerda, removendo-se cirurgicamente o rim direito (ratos 1R-1C). Após 14 dias, receberam injeção subcutânea de estreptozotocina (50 e 60mg/kg de peso) para indução do diabetes mellitus sendo a glicemia testada pela veia caudal previamente aos experimentos (diabéticos). Após 28 dias da implantação do clip, todos os grupos foram novamente anestesiados e implantaram-se cânulas de polietileno (PE-50) na artéria carótida esquerda e veia jugular direita, para registro direto da pressão arterial e injeção de drogas, respectivamente. Animais controle sofreram cirurgia sem implantação do clip (normotensos). O cateter arterial foi conectado ao sistema de registro computadorizado (PowerLab®) utilizando software específico (Chart 5Pro®). A pressão arterial registrada durante os primeiros 5 minutos foi considerada como valor basal. Analisaram-se: a integral da resposta, menor resposta hipotensora, maior resposta hipertensora, duração e intervalo de tempo para atingir respostas máxima e mínima, em todos os grupos, para cada dose injetada dos dois vasoconstritores. No dia seguinte, foi medida a glicemia inicial e após a injeção das doses de 160 e 640ng (adrenalina) ou 0,25 e 2 x10-3UI (felipressina). Os dados foram submetidos à análise de variância de medidas repetidas (ANOVA), seguida do teste de Holm-Sidak (distribuição normal) ou de Mann-Whitney (paramétrico), quando apropriado, nível de significância de 5%. A felipressina, ao contrário da adrenalina, não apresentou ação hipotensora além de apresentar menor efeito hipertensor global e maior duração da resposta. Animais diabéticos e hipertensosdiabéticos apresentaram menor resposta hipotensora à adrenalina, maior resposta hipertensora e respostas significativamente mais duradouras, evidenciando maior sensibilidade aos efeitos deste vasoconstritor. Animais hipertensos apresentaram aumento da integral das respostas, especialmente com grandes doses, evidenciando maior sensibilidade aos efeitos da administração exógena de adrenalina. Nos animais hipertensos-diabéticos a resposta pressora à felipressina foi potencializada. Animais diabéticos e hipertensos-diabéticos apresentaram resposta hiperglicêmica após injeção de 640ng de adrenalina, enquanto apenas o grupo de hipertensos-diabéticos apresentou elevação da glicemia após injeções de ambas as doses de felipressina. Os resultados apontam, de modo geral, para um aumento da sensibilidade aos agentes vasoconstritores na presença simultânea de hipertensão e diabetes. Além disso, somente os hipertensos-diabéticos tiveram elevação da glicemia após injeção de doses baixas de felipressina (0,25mUI). Entretanto, a felipressina demonstrou menores picos hipertensivos, apesar de sua longa duração, nos grupos estudados, o que a coloca como um possível vasoconstritor a ser utilizado em portadores de cardiopatias, incluindo diabéticos.
The present study was designed to induce arterial hypertension associated with diabetes mellitus, analyze and compare the effects of vasoconstrictors drugs, presents in anesthetic cartridge, injected by intravenous route (IV), in doses of 80, 160, 320, 640 and 1280ng (epinephrine) or 0,125; 0,25; 0,5; 1; 2 e 3x10-3UI (felypressin) on arterial pressure (AP) of normotensive, diabetic, one-kidney,one-clip (1K-1C) hypertensive and 1K-1C hypertensive-diabetic rats. The blood glucose levels were determined after IV injection of both drugs in doses that produced 20 and 80% of maximal pressure response. Male Wistar rats weighing 110-160g were anesthetized with a ketamine and xylazine mixture (50+10mg/ml/kg de peso). After abdominal incision, a silver clip with 0.25-mm gap was implanted in the main left renal artery and right kidney was removed (1K-1C rats). Fourteen days after, some animals received subcutaneous injection of streptozotocin (50 and 60mg/kg weight) to induce diabetes mellitus. Tail blood glucose was tested before experiments (diabetics rats). Four weeks after clip implantation all rats were anesthetized again and a catheter (PE50) was inserted into the left carotid artery and right jugular vein, respectively to obtain a direct arterial pressure register and to inject drugs. Control groups were submitted to surgery procedures without clip installation (normotensive). The arterial catheter was then connected to the transducer and to the computer register system (PowerLab®) using a Chart 5 Pro® software. The AP registered in the first five minutes was considered as a basal value. The following parameters were registered: integral of complete response, minimal hypotensive response, maximal hypertensive response, response length (duration) and duration of time to attain maximum and minimum responses, in all animals groups, to every injected dose of both vasoconstrictor drugs. In the next day blood glucose levels were determined initially and after venous injection of 160 e 640ng (adrenaline) or 0,25 an 2 x10-3UI (felipressin). Data were analyzed by one and two ways repeated measures ANOVA followed by Holm-Sidak (normal distribution) or Mann-Whitney (parametric) test, when appropriated. The significance level was 5%. Felypressin didnt show hypotensive effects and produced lower hypertensive responses with prolonged time lengths when compared with epinephrine. The hypotensive response to epinephrine was reduced in diabetic and hypertensive-diabetic rats, and the hypertensive responses were higher and prolonged. These results together suggest increased sensibility to the pressure effects of epinephrine. Hypertensive rats showed increased integral of pressures responses, especially in higher doses, also suggesting increased sensibility to epinephrine. Felypressin responses were potentiated in hypertensive-diabetic group. Diabetic and hypertensive-diabetic rats showed increased blood glucose levels after 640ng epinephrine injection, whereas only hypertensive-diabetic rats had increased values of blood glucose after felypressin injections, at both doses. These results together indicate increased sensibility to both drugs in diabetes association with arterial hypertension. Felypressin presented less hypertensive peak and longer length of activity in all studied groups, what suggests that felypressin, in the concentration used in dental anesthetic solutions, may be a secure vasoconstrictor drug in cardiac patients, including diabetics.

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Eid, Samer Rafic. "Analysis of Pod-1 gene function and Na,K-ATPhase, SGLT-1L, and AT1 receptor expression during pronephric kidney development in Xenopus /". Zürich : [s.n.], 2002. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=14599.

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Muckel, Florian [Verfasser], Markus [Akademischer Betreuer] Morgenstern i Samir [Akademischer Betreuer] Lounis. "Sub 1K UHV scanning tunneling microscope made of shapal and mapping of magnetic skyrmion collapse rates / Florian Muckel ; Markus Morgenstern, Samir Lounis". Aachen : Universitätsbibliothek der RWTH Aachen, 2020. http://d-nb.info/1225878837/34.

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Wendling, Nathalie. "Dispositif de mesure du pouvoir thermoélectrique et de la conductivité thermique de petits échantillons entre 1K et 350K : application à YBa2Cu3O(7-x)". Grenoble 1, 1993. http://www.theses.fr/1993GRE10127.

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Nous presentons dans ce memoire la mise au point et la realisation d'un dispositif experimental pour les mesures du pouvoir thermoelectrique (pte) et de la conductibilite thermique de petits echantillons. La technique de mesure utilisee a necessite la determination des pte relatif et absolus d'un nouveau thermocouple de reference forme d'un fil d'or de diametre 17,5 micrometres et d'un fil d'aluminium-silicium de diametre 25 micrometres. Nous avons ainsi montre que le pte de au ne peut pas etre represente entre 80 et 350 k par un simple terme de diffusion, puisque le terme de phonon drag contribue a 100 k a plus de 40% de la valeur du pte total. Entre 80 et 350 k, le pte de l'or est bien represente par une formule analytique simple et son utilisation pour l'etude des supraconducteurs a htc est particulierement interessante. La realisation du contact thermique et electrique des thermocouples directement sur des echantillons de petites dimensions comprend une etape de metallisation et de gravure de deux electrodes. Pour mesurer les tensions thermoelectriques, nous avons mis au point un ensemble de deux nanovoltmetres comprenant des hacheurs a transistors asga et fonctionnant dans l'azote liquide. Ce dispositif permet de mesurer des tensions continues inferieures aux microvolts, avec une precision de quelques pourcents. L'ensemble de ce dispositif est utilise pour determiner les proprietes de transport d'une ceramique, d'une ceramique texturee sous champ et d'un monocristal d'yba2cu3o7-x. Les echantillons presentent tous les trois une resistivite lineaire en t. Les pte de la ceramique et du monocristal sont proches l'un de l'autre et de valeurs negatives entre tc et 300 k; ces valeurs correspondent a un x d'environ 0,06. L'anisotropie du pte de la ceramique texturee a ete determinee et vaut 7 a 300 k

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Iwai, Akio. "Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates β-catenin activity in a p53-dependent manner". Kyoto University, 2005. http://hdl.handle.net/2433/144711.

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Shimizu, Satoshi. "Differential Involvement of the Npl4 Zinc Finger Domains of SHARPIN and HOIL-1L in Linear Ubiquitin Chain Assembly Complex-Mediated Cell Death Protection". 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225448.

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