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Gotowa bibliografia na temat „1KB”

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Data publikacji: 25 lipca 2024

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Artykuły w czasopismach na temat "1KB"

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Kozłowska, Joanna, Ewa Grela, Dagmara Baczyńska, Agnieszka Grabowiecka i Mirosław Anioł. "Novel O-alkyl Derivatives of Naringenin and Their Oximes with Antimicrobial and Anticancer Activity". Molecules 24, nr 4 (14.02.2019): 679. http://dx.doi.org/10.3390/molecules24040679.

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In our investigation, we concentrated on naringenin (NG)—a widely studied flavanone that occurs in citrus fruits. As a result of a reaction with a range of alkyl iodides, 7 novel O-alkyl derivatives of naringenin (7a–11a, 13a, 17a) were obtained. Another chemical modification led to 9 oximes of O-alkyl naringenin derivatives (7b–13b, 16b–17b) that were never described before. The obtained compounds were evaluated for their potential antibacterial activity against Escherichia coli, Staphylococcus aureus, and Bacillus subtilis. The results were reported as the standard minimal inhibitory concentration (MIC) values and compared with naringenin and its known O-alkyl derivatives. Compounds 4a, 10a, 12a, 14a, 4b, 10b, 11b, and 14b were described with MIC of 25 µg/mL or lower. The strongest bacteriostatic activity was observed for 7-O-butylnaringenin (12a) against S. aureus (MIC = 6.25 µg/mL). Moreover, the antitumor effect of flavonoids was examined on human colon cancer cell line HT-29. Twenty-six compounds were characterized as possessing an antiproliferative activity stronger than that of naringenin. The replacement of the carbonyl group with an oxime moiety significantly increased the anticancer properties. The IC50 values below 5 µg/mL were demonstrated for four oxime derivatives (8b, 11b, 13b and 16b).
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Schwan, Adrian L., Michael R. Roche, John F. Gallagher i George Ferguson. "On the conformational preferences of the dehydrochlorination of α-chlorosulfoxides". Canadian Journal of Chemistry 72, nr 2 (1.02.1994): 312–24. http://dx.doi.org/10.1139/v94-049.

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Several acyclic α-chlorosulfoxides have been shown to undergo a γ-dehydrochlorination upon treatment with LDA. The proposed immediate products of γ-dehydrochlorination, thiirane-S-oxides, are unstable under the basic conditions and react further with the LDA; the isolated products are usually E-alkenes and (or) E-vinyl sulfoxides. Some of the proposed intermediate thiirane-S-oxides, compounds 6, 7, 8, and 18, were synthesized independently and treated with one equivalent of LDA in order to mimic the second step of the overall dehydrochlorination/ring opening sequence. The products obtained from the reactions of compounds 6 and 18 compared favourably with those products which were believed to arise from certain conformations of α-chlorosulfoxides 1kB and 1e, respectively. The addition of one equivalent of LDA to 1kA afforded a mixture containing thiirane-S-oxide 8, which is proposed as the immediate product of γ-dehydrochlorination of 1kA. The configurations of 1kB and 1hA were both shown to be threo by X-ray crystallographic studies. Those conformations which are preferred for the dehydrochlorination possess a geometry where the sulfinyl oxygen is anti to any of the substituents of the ring carbons.
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Zheng, Ling-Li, Guan Wen, Yun-Xin Yao, Xiao-Huan Li i Feng Gao. "Design, Synthesis, and Anticancer Activity of Natural Product Hybrids With Paclitaxel Side Chain Inducing Apoptosis in Human Colon Cancer Cells". Natural Product Communications 15, nr 4 (kwiecień 2020): 1934578X2091729. http://dx.doi.org/10.1177/1934578x20917298.

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Based on the strong activity dependence of paclitaxel (PTX; Taxol) or docetaxel (Taxotere) on the C-13 side chain, a small library of dehydroepiandrosterone, cholesterol, vitamin D2, and alkaloids talatisamine and songorine-PTX hybrids have been synthesized and evaluated for in vitro anticancer activity by MTT assay against human breast (MCF-7), colon (HCT116), lung carcinoma (A549), and renal adenocarcinoma (786-0) cancer cell lines. Most hybrids (11b, 12b, 13b, 15b, and 18b) reduced the growth of MCF-7 and 786-0 cells with low PTX sensitivity in vitro. Among the synthesized compounds, hybrid 11b was better in inhibiting the growth of the 4 cells than PTX. A relatively low IC50 value of compound 11b (8.16 ± 0.04 μM) was also examined after exposure for 48 hours. Hybrid 11b showed a proapoptotic effect in HCT116 cells evaluated by Annexin V/propidium iodide binding assay. The level of hybrid 11b leading to protective cell death in HCT116 cells was detected using western blot and not easily observed in our basic examinations.
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Hřebabecký, Hubert, Milena Masojídková i Antonín Holý. "Synthesis of Racemic 2-Hydroxy-4- and 2-Hydroxy-5-(hydroxymethyl)cyclohexane Nucleoside Analogues". Collection of Czechoslovak Chemical Communications 67, nr 11 (2002): 1681–99. http://dx.doi.org/10.1135/cccc20021681.

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New racemic 2-hydroxy-4- and 2-hydroxy-5-(hydroxymethyl)cyclohexane analogues of adenine (10b and 16b) and thymine nucleosides (13b and 19b) were prepared by alkylation of 1,8-diazabicyclo[5.4.0]undec-7-ene salt of adenine and/or thymine with 3-vinyl-7-oxabicyclo[4.1.0]heptane followed by cis hydroxylation with osmium(VIII) oxide and sodium chlorate, oxidation with sodium periodate, and borohydride reduction.
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Yu, Yi-Ning, Hui-Ling Yang, Li-Yan Jin, Ji-Hye Jang, Pan-Bong Ha i Young-Hee Kim. "Design of Low-Area and Low-Power 1-kbit EEPROM". Journal of the Korean Institute of Information and Communication Engineering 15, nr 4 (30.04.2011): 913–20. http://dx.doi.org/10.6109/jkiice.2011.15.4.913.

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Tilbrook, Rosanna H., Matthew R. Burleigh, Jean C. Costes, Samuel Gill, Louise D. Nielsen, José I. Vines, Didier Queloz i in. "NGTS 15b, 16b, 17b, and 18b: four hot Jupiters from the Next-Generation Transit Survey". Monthly Notices of the Royal Astronomical Society 504, nr 4 (30.03.2021): 6018–32. http://dx.doi.org/10.1093/mnras/stab815.

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ABSTRACT We report the discovery of four new hot Jupiters with the Next-Generation Transit Survey (NGTS). NGTS-15b, NGTS-16b, NGTS-17b, and NGTS-18b are short-period (P < 5 d) planets orbiting G-type main-sequence stars, with radii and masses between 1.10 and 1.30RJ and 0.41 and 0.76MJ, respectively. By considering the host star luminosities and the planets’ small orbital separations (0.039–0.052 au), we find that all four hot Jupiters are highly irradiated and therefore occupy a region of parameter space in which planetary inflation mechanisms become effective. Comparison with statistical studies and a consideration of the planets’ high incident fluxes reveal that NGTS-16b, NGTS-17b, and NGTS-18b are indeed likely inflated, although some disparities arise upon analysis with current Bayesian inflationary models. However, the underlying relationships that govern radius inflation remain poorly understood. We postulate that the inclusion of additional hyperparameters to describe latent factors such as heavy element fraction, as well as the addition of an updated catalogue of hot Jupiters, would refine inflationary models, thus furthering our understanding of the physical processes that give rise to inflated planets.
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Kalpakchieva, R., H. G. Bohlen, W. von Oertzen, B. Gebauer, M. von Lucke-Petsch, T. N. Massey, A. N. Ostrowski, Th Stolla, M. Wilpert i Th Wilpert. "Spectroscopy of 13B, 14B, 15B and 16B using multi-nucleon transfer reactions". European Physical Journal A 7, nr 4 (kwiecień 2000): 451–61. http://dx.doi.org/10.1007/pl00013641.

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Mohareb, Rafat Milad, i Ibram Refat Mikhail. "Synthesis of Thiazole, Thiophene, Pyran and Pyridine Derivatives Derived from 3-phenyl-1H-pyrazol-5(4H)-one with Anti-proliferative, Tyrosine Kinase and PIM-1 Kinase Inhibitions". Letters in Drug Design & Discovery 17, nr 4 (25.04.2020): 485–501. http://dx.doi.org/10.2174/1570180816666190618105907.

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Background: A wide range of pyrazole derivatives gained special attention due to their wide range of pharmacological activities especially the therapeutic activities. Many pharmacological drugs containing the pyrazole nucleus are known in the market. Methods: The 3-phenyl-1H-pyrazol-5(4H)-one was the key starting compound for many heterocyclic reactions to produce substituted and fused pyrazole derivatives. Results: Antiproliferative activities of the produced compounds against six cancer cell lines A549, HT-29, MKN-45, U87MG, and SMMC-7721 and H460 were measured through which compounds showed high inhibitions. The most promising compounds were tested against tyrosine kinases (c-Kit, Flt-3, VEGFR-2, EGFR, and PDGFR). Structure-Activity Relationship (SAR) was rationalized by looking at the varying structural features of the molecules. In addition, the most active compounds were selected for Pim-1 inhibition. Conclusion: Thirty-nine pyrazole derivatives were synthesized. Nine of them 8b, 9, 12b, 12d, 14b, 15b, 18d, 18f, 19b, and 21d were the most active compounds toward the selected cancer cell lines. Compounds 12b, 14b, 18d, 18f, and 21d showed high inhibitions toward the tyrosine kinases, whereas compounds 14b, 18d, and 18f were the most potent inhibitors of Pim-1.
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ZHANG, Sizhong, Weimin QIU, Hui WU, Ge ZHANG, Mingkong HUANG, Cuiying XIAO, Jun YANG i in. "The shorter zinc finger protein ZNF230 gene message is transcribed in fertile male testes and may be related to human spermatogenesis". Biochemical Journal 359, nr 3 (25.10.2001): 721–27. http://dx.doi.org/10.1042/bj3590721.

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The zinc finger gene family represents one of the largest in the mammalian genome, with several of these genes reported to be involved in spermatogenesis. A newly discovered gene has been identified that is expressed abundantly in the testicular tissue of fertile men as determined by mRNA differential display. The gene encodes a C3HC4-type zinc finger protein motif (ring finger motif) consistent with a role in pre-meiotic or post-meiotic sperm development. The gene was named ZNF230 and mapped to the short arm of chromosome 11 (11p15). ZNF230 has two transcripts, of 1kb and 4.4kb in length. The shorter 1kb transcript was only detected in testicular tissue whereas the longer 4.4kb transcript was not detected in testis but was found in several other tissues. The lack of detectable ZNF230 expression in azoospermic patients by reverse transcriptase-mediated PCR analysis is interpreted to mean that this gene is involved in maintaining normal human male fertility.
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Margaritis, Lukas H. "The eggshell of Drosophila melanogaster. II. New staging characteristics and fine structural analysis of choriogenesis". Canadian Journal of Zoology 64, nr 10 (1.10.1986): 2152–75. http://dx.doi.org/10.1139/z86-330.

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The characteristics of the stages of choriogenesis have been identified using light and electron microscopy. Nine stages have been discerned (11A, 11B, 12A, 12B, 12C, 13A, 13B, 14A, 14B), replacing the four stages used so far (11, 12, 13, 14). Characteristics used to determine the stage of the choriogenesis include (a) the size of oocyte as compared with the whole follicle, (b) the length of the chorionic appendages, and (c) the fine structure of the chorionic layers at the main shell and at the specialized regions. Factors a and b were detected by dark-field light microscopy on living follicles, whereas factor c was studied with electron microscopy. At stage 11A the vitelline membrane has just been completed. At stage 11B the follicle cells secrete the wax layer and the respiratory appendages start to form. Stage 12A follicles secrete endochorion at the anterior pole and the appendages elongate, whereas at stage 12B the main shell follicle cells start to secrete endochorion complex. Stage 12C shows initiation of pillar formation at the main shell and 150 μm long appendages. Stage 13A is characterized by 200 μm long appendages and formation of endochorionic cavities at the main shell, through the participation of a "flocculent" material. At stage 13B the endochorionic "roof is formed, which is completed at stage 14A by the simultaneous formation of the "roof network." The last stage, 14B, exhibits 300 μm long appendages and the secretion of exochorion over the entire follicle. The above stages are accompanied by region-specific formation of specialized structures which include the respiratory appendages, the operculum, the posterior pole, the micropyle, and the collar.
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Rozprawy doktorskie na temat "1KB"

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Nfor, Nformi Emmanuel. "Sequence stratigraphic characterisation of petroleum reservoirs in Block 11b/12b of the Southern Outeniqua Basin". University of the Western Cape, 2011. http://hdl.handle.net/11394/2924.

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Magister Scientiae - MSc
The main purpose of this study was to identify and characterize the various sand prone depositional facies in the deepwater Southern Outeniqua Basin which generally tend to form during lowstand (marine regression) conditions producing progradational facies. It made use of sequence stratigraphy and turbidite facies models to predict the probable location of deepwater reservoirs in the undrilled Southern Outeniqua Basin using data from basin margin Pletmos Basin and the deepwater Southern Outeniqua Basin. Basin margin depositional packages were correlated in time and space with deepwater packages. It was an attempt at bridging the gap between process-related studies of sedimentary rocks and the more traditional economic geology f commercial deposits of petroleum using prevailing state-of-the-art in basin analysis. It enabled the most realistic reconstructions of genetic stratigraphy and offered the greatest application in exploration. Sequence stratigraphic analysis and interpretation of seismics, well logs, cores and biostratigraphic data was carried out providing a chronostratigraphic framework of the study area within which seismic facies analysis done. Nine (9) seismic lines that span the shallow/basin margin Pletmos basin into the undrilled deepwater Southern Outeniqua basin were analysed and interpreted and the relevant seismic geometries were captured. Four (4) turbidite depositional elements were identified from the seismic lines: channel, overbank deposits, haotic deposits and basin plain (basin floor fan) deposits. These were identified from the relevant seismic geometries (geometric attributes) observed on the 2D seismic lines. Thinning attributes, unconformity attributes and seismic facies attributes were observed from the seismic lines. This was preceded by basic structural analyses and interpretation of the seismic lines. according to the structural analysis and interpretation, deposition trended NW-SE and NNW-SSE as we go deepwater into the Southern Outeniqua basin. Well logs from six (6) of the interpreted wells indicated depositional channel fill as well as basin floor fans. This was identified in well Ga-V1 and Ga-S1 respectively. A bell and crescent shape gamma ray log signature was observed in well Ga-V1 indicating a fining up sequence as the channel was abandoned while an isolated massive mound-shape gamma ray log signature was observed in Ga-S1 indicating basin plain well-sorted sands. Core analyses and interpretation from two southern-most wells revealed three (3) facies which were derived based on Walker‘s 1978, turbidite facies. The observed facies were: sandstone, sand/shale and shale facies. Sequence stratigraphic characterisation of petroleum reservoirs in block 11b/12b of the Southern Outeniqua Basin. Cores of well Ga-V1 displayed fine-grained alternations of thin sandstone beds and shales belonging to the thin-bedded turbidite facies. This is typical of levees of the upper fan channel but could easily be confused with similar facies on the basin plain. According to Walker, 1978 such facies form under conditions of active fan progradation. Ga-S1 cores displayed not only classic turbidite facies where there was alternating sand and shale sections but showed thick uninterrupted sections of clean sands. This is typical of basin plain deposits. Only one well had biostratigraphic data though being very limited in content. This data revealed particular depth sections and stratigraphic sections as having medium to fast depositional rates. Such rates are characteristic of turbidite deposition from turbidity currents. This study as well as a complementary study by Carvajal et al., 2009 revealed that the Southern Outeniqua basin is a sand-prone basin with many progradational sequences in which tectonics and sediment supply rate have been significant factors (amongst others such as sea level change) in the formation of these deepwater sequences. In conclusion, the Southern Outeniqua basin was hereby seen as having a viable and unexplored petroleum system existing in this sand prone untested world class.
South Africa
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Surdej, Patrick. "L' organisation strucrurale et fonctionnelle de la région 14B-15B du chromosome X de Drosophila melanogaster". Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX22055.

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Clonage d'un brin d'adn de 800 kb du chromosome x de la drosophile (15b-15b). Organisation des regions transcrites et profil d'expression au cours du developpement, caracterisation de regions d'attachement a la matrice nucleaire
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Brun, Christine. "Organisation en boucles de la molécule d'ADN et réplication : tude de la région 14B-15B du chromosome X et de l'unité des gènes ribosomiques de Drosophila melanogaster". Aix-Marseille 2, 1992. http://www.theses.fr/1992AIX22017.

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La molecule d'adn, constitutive du chromosome eucaryote, est organisee en boucles dont les bases sont ancrees dans un reseau proteique interne nomme scaffold. L'implication des sites d'attachement de la molecule d'adn au scaffold (=sar) dans les mecanismes de replication a ete etudiee dans deux regions distinctes du genome de la drosophile: la region 14b-15b du chromosome x, mesurant 800 kb, qui a ete clonee dans le laboratoire et dont l'organisation en boucles a ete determinee lors d'une etude anterieure, et l'unite des genes codant pour les arns ribosomiques. Dans une premiere etape, l'activite de replication autonome (=ars) de fragments de restriction representatifs de la region 14b-15b a ete testee par transformation heterologue de levure. 27 fragments manifestent une activite ars. 25 d'entre eux sont des sars. Il existe donc une correlation entre les deux types d'activites: une sous-classe de sars de drosophile est impliquee dans les mecanismes de replication extrachromosomique chez la levure. De plus, l'association au scaffold est conservee entre les deux especes: lors d'un test de re-association in vitro, 61% des sars testes sont capables de s'associer a des scaffolds de levure. Dans une deuxieme etape, l'existence d'une relation entre sites d'attachement, sequences ars dans la levure et origines de replication chromosomiques a ete abordee. Pour cela, l'organisation en boucles de l'unite repetee des genes ribosomiques a ete determinee. Trois sars ont ete identifies a l'interieur des trois espaceurs presents dans l'unite. Ils definissent trois boucles d'adn contenant la region codant pour l'arn 18s, une partie de la region codant pour l'arn 28s et une region entourant le site +1 de transcription, respectivement. Ces 3 sars de drosophile sont egalement capables de s'associer a des scaffolds de levure. Trois regions de l'unite sont impliquees dans les mecanismes de replication extrachromosomique chez la levure. Elles correspondent aux regions en interaction avec le scaffold. De plus, la technique d'electrophorese bidimensionnelle neutre/neutre a permis de localiser une origine de replication chromosomique dans un fragment d'adn couvrant deux des espaceurs. Ces resultats montrent donc qu'au moins dans un cas, une proximite topologique existe entre des sequences impliquees dans l'association de la molecule d'adn au scaffold, dans la replication extrachromosomique chez la levure et dans l'initiation de la replication chromosomique. Cela suggere une relation fonctionnelle etroite entre ces trois types de sequences
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Lau, Peggy. "The role of 4-1BB/4-1BB ligand costimulation in T cell responses". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58825.pdf.

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Frerichs, Stefan, Karl Hamacher i André Simon. "Sündenfall § 13b BauGB? Eine Bestandsaufnahme". Rhombos-Verlag, 2020. https://slub.qucosa.de/id/qucosa%3A76161.

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Zwei Jahre nach Einführung des § 13b BauGB sind bundesweit bereits zahlreiche Anwendungsfälle bekannt. Sie zeigen, dass sich die Erwartungen an die Einführung der Regelung, auf Kosten von materiellen und Verfahrensstandards schnell und in substantiellem Umfang Wohnbauland zur Minderung der Wohnungsnot zu schaffen, nicht erfüllt haben. Einwohnerstarke Städte mit hohem Wohnraumbedarf und angespannten Wohnungsmärkten wenden die neuen Regelungen nicht an. Die Nutzung des § 13b BauGB erfolgt in kleineren und kleinsten Gemeinden, häufig ohne besonderen Wohnraumbedarf, zur Ausweisung von Ein- und Zweifamilienhausgebieten. In vielen Fällen lässt sich feststellen, dass die Flächeninanspruchnahme für Siedlungszwecke unnötig verstärkt wird und viele dieser Gemeinden Wohnbaulandflächen auf Vorrat ausweisen, die mit Blick auf die Bevölkerungsentwicklung voraussichtlich nicht notwendig sein werden. Damit einher geht eine unnötige Belastung von Umwelt und Natur einerseits und Entwertung des innerörtlichen Baubestandes andererseits.
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Ralston, James. "The 10B(n, α) and 10B(n, p) Cross-Sections in the MeV Energy Range". Ohio University Honors Tutorial College / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1315160730.

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Roberto, Gabriela Molinari. "Influência do miR-10b na proliferação e capacidade invasiva de osteossarcoma". Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17154/tde-12042018-120108/.

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O Osteossarcoma (OS) é o tumor ósseo pediátrico mais comum. O tratamento atual consiste em remoção cirúrgica e quimioterapia multimodal neo- e adjuvante. No entanto, um terço dos pacientes são acometidos por recorrência pós-cirúrgica e metástases distantes sendo que apenas 20% daqueles com metástase sobrevivem após 5 anos. Diversos miRNAs vêm sendo apontados como metastamiRs, dentre eles o miR-10b. Este microRNA encontra-se hiperexpresso em uma série de tumores e associado a pior prognóstico. Estudos prévios têm demostrado que o miR-10b atua nos processos invasivos principalmente pareando-se de forma incompleta com o RNA mensageiro do gene HOXD10 e assim inibindo a sua tradução. Este fator de transcrição, assim como todos os membros da família dos genes HOX, exerce sua função ativando e reprimindo genes vitais para os processos de crescimento e diferenciação celular (inclusive durante o desenvolvimento do tecido ósseo), sendo também descrito como desregulado em diversos tumores. Em vista disso, o presente trabalho teve como objetivo estudar a influência do miR-10b no OS e sua associação com o gene HOXD10 em relação aos processos de proliferação, invasão e migração celular. Para tanto, foi avaliada a expressão de ambos em amostras tumorais, bem como os efeitos da modulação da expressão de miR-10b na capacidade proliferativa e invasiva de linhagens celulares de OS. Nossos resultados mostraram uma associação inversa entre os níveis de expressão do miR-10b e o grau de malignidade. O aumento de miR-10b in vitro levou a supressão da capacidade clonogênica e à redução dos processos de adesão, migração e invasão, sugerindo um papel de supressor tumoral em OS. Não foi encontrada correlação entre a expressão gênica do miR-10b e a do HOXD10, e ainda o aumento deste microRNA não alterou a expressão proteica do fator de transcrição. Sendo assim, o mecanismo pelo qual miR-10b contribui para a agressividade do OS permanece indefinido, mas parece ser independente de HOXD10. Paralelamente, a expressão do gene KLF4 (recentemente descrito como alvo direto de miR-10b) e de genes sabidamente associados à invasão (MMP2 e ROCK1) e proliferação (TP53 e BCL2) tampouco foi afetada após transfecção. Por outro lado, apesar de não ter sido confirmado como alvo de miR-10b no nosso estudo, HOXD10 foi encontrado significativamente hiperexpresso nas amostras de OS. Assim, considerando a importância da desregulação de vias de desenvolvimento no surgimento de tumores pediátricos e a participação do HOXD10 no desenvolvimento ósseo, o seu papel como oncogene e seu potencial como alvo terapêutico neste tipo tumoral merecem estudos posteriores.
Osteosarcoma (OS) is the most common pediatric bone tumor. The current treatment consists of surgical removal and neo- and adjuvant multimodal chemotherapy. Nonetheless, one-third of patients are affected by post-surgical recurrence and distant metastases, with only 20% of metastatic cases surviving after 5 years. Several miRNAs have been designated as metastamiRs, among them miR-10b. This microRNA is overexpressed in a series of tumors and associated with poor prognosis. Previous studies have shown that miR-10b acts on invasive processes mainly by pairing with the messenger RNA of the HOXD10 and thereby inhibiting its translation. This transcription factor, like all members of the HOX family, exerts its function by activating and/or repressing vital genes for cell growth and differentiation (even during the development of bone tissue) and is also described as deregulated in several tumors. In view of this, the aim of this work was to study the influence of miR-10b on OS and its association with the HOXD10 in relation to proliferation, invasion and cell migration. For this, the expression of both genes in tumor samples, as well as the effects of miR-10b expression modulation on the proliferative and invasive capacity of OS cell lines, were evaluated. Our results showed an inverse association between miR-10b expression levels and the degree of malignancy. The increase of miR-10b in vitro led to the suppression of clonogenic capacity and reduction of adhesion, migration and invasion, suggesting a role as a tumor suppressor in OS. No correlation was found between the gene expression of miR-10b and HOXD10, while the increase of the microRNA did not alter the protein levels of the transcription factor. Thus, the mechanism by which miR- 10b could contribute to OS aggressiveness remains undefined, though it appears to be independent of HOXD10. In parallel, the expression of KLF4 (recently described as a direct miR-10b target) and of genes known to be associated with invasion (MMP2 and ROCK1) and proliferation (TP53 and BCL2) was not affected after transfection. On the other hand, although HOXD10 was not confirmed as a miR-10b target in our study, this gene was found to be significantly overexpressed in the OS samples. Thus, considering the importance of the deregulation of developmental pathways on pediatric tumors and HOXD10 contribution on bone development, its role as an oncogene and its potential as a therapeutic target in this tumor type deserves further studies.
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Ferreira, Andre Vargas. "Síntese de aminoácidos não-proteinogênicos enriquecidos em 10B utilizados na Terapia de Captura de Nêutrons por Boro (BNCT)". Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/64/64135/tde-03092013-160315/.

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O Glioblastoma Multiforme (GMB), tipo de câncer cerebral mais comum e agressivo, apesar dos recentes avanços na pesquisa em neurociência, é muitas vezes incurável e com prognóstico obscuro. Diante da resistência e da inespecificidade dos tratamentos frente a esses tumores, o maior desafio atualmente está no desenvolvimento de estratégias moleculares mais específicas às células cancerígenas e menos agressivas aos pacientes. A terapia de captura de nêutrons por boro, comumente conhecida como BNCT (do inglês Boron Neutron Capture Therapy) fornece um caminho de destruição seletiva das células tumorais poupando as normais, sendo esta terapia baseada na reação de fissão nuclear entre o 10B, um dos isótopos estáveis de boro, e nêutrons de baixa energia. Destaca-se a utilização de isótopos estáveis na área biomédica pelo fato destes serem inócuos ao organismo dos pacientes e não possuírem limite de dosagem. Desta forma, o objetivo do presente trabalho consiste na síntese do principal fármaco utilizado na BNCT, o L-4-borofenilalanina enriquecido em 10B. Para isso, utilizou-se da reação de Morita-Baylis-Hillman (MBH) cuja definição geral é uma condensação entre carbonos eletrofílicos sp2 e a posição \'alfa\' de uma olefina com grupos retiradores de elétrons ativada por uma amina terciária ou uma fosfina, gerando uma nova ligação \'sigma\'C-C. Essa reação apresenta algumas vantagens que evidenciam as reações de MBH como uma metodologia sintética eficiente: são regio e quimioseletivas; possuem uma elevada economia de átomos, necessitam condições brandas de trabalho fornecendo. Estabeleceu-se metodologia para a síntese do 4-bromofenilalanina, precursor do fármaco L-4-borofenilalanina por meio de duas abordagens sintéticas inéditas e distintas. A ampliação do escopo dessa sequência de reações para sintetizar outros aminoácidos não-proteinogênicos demonstra a robustez da nova rota sintética abrindo a possibilidade de síntese de outros aminoácidos enriquecidos em isótopos estáveis de elementos leves com aplicação biomédica. A primeira abordagem sintética compreendeu 6 etapas e foi possível obter um rendimento global de 24%. A segunda abordagem sintética foi realizada em 4 etapas possibilitando obter o mesmo aminoácido com rendimento global de 46%
Glioblastoma Multiforme (GMB), a most common and aggressive type of brain cancer, in spite of recent advances in neuroscience research, is often incurable and the prognosis is obscure. In front of the resistance and specificity of the treatments against these tumors, the biggest challenge nowadays is to develop molecular strategies more specific to tumor cells and less aggressive for the patient. Boron Neutron Capture Therapy (BNCT) provides a path of selective destruction of tumor cells sparing the normal ones, which this therapy based on nuclear fission reaction between 10B, one of the stable isotopes of boron and low-energy neutrons. Emphasizes the use of stable isotopes in the biomedical area because these are innocuous to the body of the patients and do not have limit dosage. Thus, the aim of this master is the synthesis of the main drug used in BNCT, the L-4-boronophenylalanine enriched in 10B. For this, we used the Morita-Baylis-Hillman (MBH) which definition is a condensation between sp2 eletrophilic carbon and the position \'alfa\' of an olefin activated by tertiary amine or phosphine, generating a new \'sigma\'C-C bond. This reaction has some advantages that evidence the reactions of MBH as an efficient synthetic methodology: are regio and quimioselective, have high atom economy, require mild conditions providing polifunctionalized molecules that through small changes in chemical structure can generate a series of synthetic intermediates, pharmaceuticals, etc. It was established methodology for the synthesis of 4-bromophenylalanine, drug precursor of L-4-boronophenylalanine through two distinct and previously unreleased synthetic approaches. The expansion of the scope of this sequence of reactions to synthesize other non-proteinogenic amino acids demonstrates the robustness of the new synthetic route opening up the possibility of synthesis of other amino acids enriched in stable isotopes with biomedical application. The first approach consisted 6 steps and it was possible to obtain an overall yield of 24%. The second approach was performed in 4 synthetic steps obtaining the same amino acid with an overall yield of 34.77%
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Stenz, Oliver [Verfasser]. "§ 15b EStG – Verlustverrechnungsbeschränkungen bei Steuerstundungsmodellen / Oliver Stenz". Aachen : Shaker, 2010. http://d-nb.info/1081885467/34.

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Neumann-Cosel, Matthias Sigurd v. "Die Reichweite des Insiderverzeichnisses nach 15b WpHG /". Frankfurt, M. [u.a.] : Lang, 2008. http://d-nb.info/98852046X/04.

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Książki na temat "1KB"

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Company, Hewlett-Packard, red. HP-17B II business calculator owner's manual. Wyd. 3. Corvallis, OR: Corvallis Division, 1994.

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Amembal, Sudhir P. Leasing applications for the HP-17B. Salt Lake City, UT: A&H, 1991.

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Lau, Peggy. The role of 4-1BB/4-1BB ligand costimulation in T cell responses. Ottawa: National Library of Canada, 2001.

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Walch, John. Aisle 17B: A short play. New York: Playscripts, Inc., 2005.

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Library of Congress. Congressional Research Service, red. Mutual funds: 12b-1 reform. [Washington, D.C.]: Congressional Research Service, Library of Congress, 1989.

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Library of Congress. Congressional Research Service, red. Mutual funds: 12b-1 reform. [Washington, D.C.]: Congressional Research Service, Library of Congress, 1989.

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Jian, Tan. 1K jian yu =: 1K prison. Wyd. 8. Taibei Xian Shulin Shi: Cheng yang chu ban gu fen you xian gong si, 2001.

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Heimer, Olle. Öresundsförbindelsen, Södra Sallerup 15B, D-E. Malmö: Malmö Kulturmiljö, 2006.

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Toten, Teresa. De onverwachte held van kamer 13B. Haarlem: Gottmer, 2014.

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Boles, Melanie. MCP1811A/11B/12A/12B Family Data Sheet. Microchip Technology Incorporated, 2020.

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Części książek na temat "1KB"

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Olive, Keith A. "Implications of the B/Be and 11B/10B Ratios". W The Light Element Abundances, 410–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-540-49169-9_64.

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Lötz, A., i J. Voitländer. "The 10B- and 11B-Nuclear Quadrupole Coupling of P-Carborane". W 25th Congress Ampere on Magnetic Resonance and Related Phenomena, 542–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-76072-3_284.

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Bonnefon-Tort, Laure. "Neo-Sexuality". W Psychoanalysts in Session, 211–13. Abingdon, Oxon; New York, NY: Routledge, 2021. | Series: The new library of psychoanalysis | “Published in French, 2016”–Title page verso.: Routledge, 2020. http://dx.doi.org/10.4324/9780429196751-10b.

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Alfandary, Isabelle. "The Partial Object or Objet (a)". W Psychoanalysts in Session, 223–24. Abingdon, Oxon; New York, NY: Routledge, 2021. | Series: The new library of psychoanalysis | “Published in French, 2016”–Title page verso.: Routledge, 2020. http://dx.doi.org/10.4324/9780429196751-11b.

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Tamet, Jean-Yves. "The Mother'S Father". W Psychoanalysts in Session, 244–46. Abingdon, Oxon; New York, NY: Routledge, 2021. | Series: The new library of psychoanalysis | “Published in French, 2016”–Title page verso.: Routledge, 2020. http://dx.doi.org/10.4324/9780429196751-12b.

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Tamet, Jean-Yves. "Creative Hypochondria". W Psychoanalysts in Session, 271–73. Abingdon, Oxon; New York, NY: Routledge, 2021. | Series: The new library of psychoanalysis | “Published in French, 2016”–Title page verso.: Routledge, 2020. http://dx.doi.org/10.4324/9780429196751-13b.

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Ody, Michel. "Oedipus as an Attractor". W Psychoanalysts in Session, 292–94. Abingdon, Oxon; New York, NY: Routledge, 2021. | Series: The new library of psychoanalysis | “Published in French, 2016”–Title page verso.: Routledge, 2020. http://dx.doi.org/10.4324/9780429196751-14b.

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Laurent, Françoise. "The Double Taboo on Touching". W Psychoanalysts in Session, 318–20. Abingdon, Oxon; New York, NY: Routledge, 2021. | Series: The new library of psychoanalysis | “Published in French, 2016”–Title page verso.: Routledge, 2020. http://dx.doi.org/10.4324/9780429196751-15b.

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Dhar, Sandipan, i Sahana M. Srinivas. "Special Groups". W Comprehensive Textbook on Vitiligo, 71–75. First edition. | Boca Raton, FL : CRC Press, 2020.: CRC Press, 2020. http://dx.doi.org/10.1201/9781315112183-15b.

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Ishizu, Tomoko, Yasuhiko Abe i Yoshihiro Seo. "Tissue Tracking". W 3D Echocardiography, 223–34. Third edition. | Boca Raton : CRC Press, 2020.: CRC Press, 2020. http://dx.doi.org/10.1201/9780429287534-18b.

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Streszczenia konferencji na temat "1KB"

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Wada, Nagasawa, Ishida, Hidaka, Tsuge i Tahara. "A 570ps, 13mW Josephson 1kb Ram". W 1988 IEEE International Solid-State Circuits Conference. IEEE, 1988. http://dx.doi.org/10.1109/isscc.1988.663641.

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Kobayashi, N., S. Notomi, M. Suzuki, T. Tsuchiya, K. Nishiuchi, K. Odani, A. Shibatomi, T. Mimura i M. Abe. "A Fully Operational 1Kb HEMT Static RAM". W GaAs IC Symposium Technical Digest. IEEE, 1985. http://dx.doi.org/10.1109/gaas.1985.10399553.

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Chang, Ming-Hung, Yi-Te Chiu, Shu-Lin Lai i Wei Hwang. "A 1kb 9T subthreshold SRAM with bit-interleaving scheme in 65nm CMOS". W 2011 International Symposium on Low Power Electronics and Design (ISLPED). IEEE, 2011. http://dx.doi.org/10.1109/islped.2011.5993652.

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Xue, Er-juan, i Chang-chun Bao. "1kb/s waveform interpolation speech coding based on non-negative matrix factorization". W 2008 9th International Conference on Signal Processing (ICSP 2008). IEEE, 2008. http://dx.doi.org/10.1109/icosp.2008.4697186.

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Liu, Rui, Huaqiang Wu, Yachun Pang, He Qian i Shimeng Yu. "Extending 1kb RRAM array from weak PUF to strong PUF by employment of SHA module". W 2017 Asian Hardware Oriented Security and Trust Symposium (AsianHOST). IEEE, 2017. http://dx.doi.org/10.1109/asianhost.2017.8353997.

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Verma, Kumkum, Sanjay Kumar Jaiswal i Mohammad Ayoub Khan. "Design of a high performance and low power 1Kb 6T SRAM using bank partitioning method". W 2011 International Conference on Multimedia, Signal Processing and Communication Technologies (IMPACT). IEEE, 2011. http://dx.doi.org/10.1109/mspct.2011.6150519.

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Kumar, Aruru Sai, K. Nishanth Rao, A. Sujith, T. Dhanuja i M. Venkata Sai Vinay. "Design and Implementation of 1KB SRAM array in 45 nm Technology for Low-Power Applications". W 2023 3rd International Conference on Advances in Computing, Communication, Embedded and Secure Systems (ACCESS). IEEE, 2023. http://dx.doi.org/10.1109/access57397.2023.10200801.

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Ogawa, Kazuo, Kiminobu Hojo, Itaru Muroya, Youichi Iwamoto i Naoki Ogawa. "Fracture Evaluation of Ni-Based Alloy Weld Joint of Cylindrical Model Subjected to 4-Point Bending or Inner Pressure". W ASME 2011 Pressure Vessels and Piping Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/pvp2011-57081.

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For the purpose of establishing fracture evaluation method of nickel based alloy weld of nuclear power plants, fracture tests using pipe models (8B and 14B for bending, 12B for inner pressure) with an alloy 132 weld joint have been performed at room temperature and high temperature (325°C). The predicted loads calculated by limit load evaluation method using the measured and code regulated flow stresses were compared with the maximum test loads. And the predicted bending loads of the pipes at 325°C (8B and 14B) and at room temperature (8B) with the initial surface crack whose depth is 75% of the pipe thickness were in good agreement with the maximum test loads. Also the predicted inner pressure of the pipe at room temperature (12B) agreed with the measured maximum pressure. Only for one case of the 14B pipe subjected to the bending load at room temperature, the predicted load by limit load evaluation method has 20% unconservative difference from the measured data, on the other hand, the predicted load by J-T analysis made this difference smaller and conservative.
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Pons, Marc, Thanh-Chau Le, Claude Arm, Daniel Severac, Stephane Emery i Christian Piguet. "A 1kb single-side read 6T sub-threshold SRAM in 180 nm with 530 Hz frequency 3.1 nA total current and 2.4 nA leakage at 0.27 V". W 2015 IEEE SOI-3D-Subthreshold Microelectronics Technology Unified Conference (S3S). IEEE, 2015. http://dx.doi.org/10.1109/s3s.2015.7333550.

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Yin-Lin, Xu, Song Ling-Gen, Zhang Yong-Xia i C. Y. Fan. "6Li/7Li, 10B/11B, and 7Li/11B/28Si in individual interplanetary dust particles". W Analysis of interplanetary dust: NASA/LPI workshop. AIP, 1994. http://dx.doi.org/10.1063/1.46534.

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Raporty organizacyjne na temat "1KB"

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Van Berkel, J. T., i K. L. Currie. Geological map of the southern Long Range, Southwest Newfoundland (12B/1, 12B/2, 12B/8, 12B/9e, 12A/4, 12A/5, 12A/12). Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1988. http://dx.doi.org/10.4095/130424.

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Scheiner, Brett Stanford, Mark J. Schmitt, Jason Mance, Derek William Schmidt, D. N. Polsin, Frederic J. Marshall, Phil Nilson i Carl Huerstel Wilde. Revolver-19B Campaign Preview. Office of Scientific and Technical Information (OSTI), sierpień 2019. http://dx.doi.org/10.2172/1558955.

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Schaefer, R. W. Sodium manometer experiment in ZPPR-15B. Office of Scientific and Technical Information (OSTI), marzec 1986. http://dx.doi.org/10.2172/711899.

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Hersey, Anne. ChEMBL Deposited Data Set - DNDI(10b). EMBL-EBI, lipiec 2014. http://dx.doi.org/10.6019/chembl3137440.

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Woolf, Reagan K. Initial Calibration of an F-16B Pacer Aircraft. Fort Belvoir, VA: Defense Technical Information Center, wrzesień 2008. http://dx.doi.org/10.21236/ada495484.

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Gulbransen, D. J., C. L. Fletcher, R. H. Wyles, A. E. Gin i J. P. Curzan. 1K x 1K and Larger Staring Focal Plane Arrays. Fort Belvoir, VA: Defense Technical Information Center, marzec 2000. http://dx.doi.org/10.21236/ada393832.

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Cohen, A. B., S. Majumdar, W. E. Ruther, M. C. Billone, H. M. Chung i L. A. Neimark. Modified ring stretch tensile testing of Zr-1Nb cladding. Office of Scientific and Technical Information (OSTI), marzec 1998. http://dx.doi.org/10.2172/305919.

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Little, W. W. Jr. 1DB, a one-dimensional diffusion code for nuclear reactor analysis. Office of Scientific and Technical Information (OSTI), wrzesień 1991. http://dx.doi.org/10.2172/6366280.

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Apfel, Robert, John Parsons, G. William Schwert i Geoffrey Stewart. Short Sales, Damages and Class Certification in 10b-5 Actions. Cambridge, MA: National Bureau of Economic Research, grudzień 2001. http://dx.doi.org/10.3386/w8618.

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Lell, Richard. Neutron Spectrum and 10B(n,{alpha}) Measurements in ZPPR-15. Office of Scientific and Technical Information (OSTI), kwiecień 2020. http://dx.doi.org/10.2172/1786972.

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