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Flanders, Michele M., Ronda A. Crist, William M. Roberts i George M. Rodgers. "Pediatric Reference Intervals for Ten Coagulation Assays." Blood 104, nr 11 (16.11.2004): 2988. http://dx.doi.org/10.1182/blood.v104.11.2988.2988.

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Abstract There is a lack of reliable pediatric reference intervals for many clinical laboratory tests. In 2002, the Children’s Health Improvement through Laboratory Diagnostics (CHILDx) organization initiated a project to collect blood and urine samples from healthy children 7 – 17 years of age with the goal of establishing reference intervals for many laboratory tests. The purpose of the present study was to determine pediatric reference intervals for ten coagulation proteins associated with common bleeding and thrombotic disorders. All assays were functional except for vonWillebrand factor antigen. All were measured according to manufacturer specifications and standard methods using the STA-R coagulation analyzer (Diagnostica Stago), with the exception of the ristocetin cofactor assay, which was performed on the BCS (Dade Behring). Samples used to establish adult reference intervals were purchased from George King Bio-Medical, Precision Biologic, and also drawn in-house. At each age of life, 62 individuals (31 girls/31 boys) were drawn for a minimum of 124 individuals for each age group. Reference intervals were established based on a nonparametric method (NCCLS C28-A). RESULTS: 1. Although pediatric PTT values do not differ from adult values, the mean pediatric PT values are about 1 sec longer, 2. Pediatric FIX levels trend upward until ages 16-17 when adult levels are reached, 3. FVIII, FXI, RCF and vWFAg demonstrate higher reference values in younger ages, 4. The lower limit of pediatric AT levels is significantly higher than adults, 5. The lower limit of pediatric protein C levels is significantly lower than adults, however, this difference is not seen for protein S levels. In conclusion, a number of significant differences between pediatric and adult reference intervals have been found supporting the use of these newer reference intervals. Age N PT PTT F VIII F IX F XI 7–9 186 13.1–15.4* 27–38 78–199* 71–138* 70–138 10–11 124 12.9–15.5* 27–38 83–226* 72–159* 63–137 12–13 124 13.1–15.2* 27–38 74–205* 73–152* 65–130* 14–15 124 12.9–15.4* 26–35 69–241* 80–162 57–125* 16–17 121 12.6–15.9* 26–35 63–225* 85–175 64–160 Adult 125 12.3–14.4 26–38 56–190 78–184 56–153 Age AT RCF VWF Ag PC PS-Male PS-Female * The t-test of the means, F-test of the SD, or both is statistically different (p< 0.05) from adult reference values. 7–9 96–135* 51–172* 62–176 71–143* 64–141 58–154 10–11 92–134* 61–195* 61–201* 76–146* 68–150 68–140* 12–13 92–128* 47–183* 61–186* 68–162* 65–143 60–150 14–15 95–135* 50–215* 57–204* 69–170* 66–149 53–147* 16–17 94–131* 47–206* 51–211 70–170* 75–157* 51–150* Adult 76–128 44–195 51–185 83–168 66–143 57–131

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Job, Neema, Ardra A. Chandran, Ashly Augustine, Rahoofa P. Palliyalli i Kottayath G. Nevin. "Sargassum wightii Greville ex J.Agardh Grevilli Extract with Macromolecular Protection Activity In Vitro: Prospecting for Novel Drug Leads Using GC-MS Based Metabolic Profiling". International Journal on Algae 25, nr 3 (2023): 267–82. http://dx.doi.org/10.1615/interjalgae.v25.i3.60.

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Marine macro alga are known to produce a plethora of bioactive metabolites with potential application in pharmaceutical and nutritional product development. In this study, the brown algae Sargassum wightii was collected along the coast of Kovalam, Thiruvananthapuram and subjected to in vitro analysis to determine their bioactive properties. The chloroform-methanol extract of S. wightii was utilized to screen and quantify phytochemical components. Further, the study examined the antioxidant potentials by lipid peroxidation inhibition, DPPH, and ABTS radical scavenging assays followed by an antibacterial activity. The capability of the extract to inhibit DNA damage and protein oxidation was also evaluated in vitro. Finally, the chemical characterization was attained using UV-Visible, FTIR, and GC-MS spectral data. Alkaloids, coumarins, flavonoids, phenols, and tannins, were detected in preliminary qualitative phytochemical analysis and their quantitative estimation revealed a significant concentration of these phytocomponents. The extract showed an IC50 value of 310.53 ± 0.35 µg/mL and 242.85 ± 0.377 µg/mL for DPPH and ABTS free radicals respectively. Whereas an IC50 of 205.42 ± 0.20 µg/mL was estimated for lipid peroxidation inhibition assay. A significant antimicrobial activity against four bacterial pathogens with a maximum zone of inhibition of > 40 mm was also observed against Staphylococcus aureus 1.5 µg/mL). The extract also demonstrated a high capability for concentration-dependent prevention of DNA damage and protein oxidation. The GC-MS spectral peaks confirmed the occurence of 17 active components with reported biological activities. These findings suggest that the extract of S. wightii, can be a lead compound for the development of a promising pharmaceutical product.

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Bertolaccini, Maria, Giovanni Sanna, Shvaita Ralhan, Laura Gennari, Joan Merrill, Graham Hughes i Munther Khamashta. "Antibodies directed to protein S in patients with systemic lupus erythematosus: prevalence and clinical significance". Thrombosis and Haemostasis 90, nr 10 (2003): 636–41. http://dx.doi.org/10.1160/th03-03-0151.

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SummaryAntibodies directed against protein S (anti-ProtS) may be involved in the development of thrombosis in patients with the antiphospholipid syndrome. We assessed the prevalence and clinical significance of anti-ProtS and evaluated their immunological characteristics in 184 patients with SLE and 99 healthy donors. All patients were tested for IgG anti-ProtS by an in-house ELISA. Plasma levels and functional activity of protein S were also tested.Anti-ProtS were found in 57 patients (31%) and 4 healthy controls (4%). Patients with thrombosis had anti-ProtS more frequently than controls (29% vs 4%, OR 9.5 [95% CI 3.07-29.3], p<0.0001). Anti-ProtS were more frequent in patients with venous thrombosis and in those with arterial thrombosis, than in controls (41% vs. 4%, OR 16.5 [95% CI 5-54], p< 0.0001 and 23% vs. 4%, OR 7 [95%CI 2.1-23.5], p=0.0008, respective-ly). Patients with prematurity, preeclampsia and intra-uterine growth restriction had anti-ProtS more frequently than the control group (36%, 47% and 44% vs. 4%; OR 13.6 [95% CI 2.8-66], p=0.003, OR 21 [95% CI 5-86], p<0.0001 and OR 19 [95% CI 4-99], p=0.0014, respectively). Plasma levels of free protein S were not statistically different between patients with and without anti-ProtS and controls (77.9% [20.7-100] vs. 83.7% [52.7-100] vs. 89% [62-101], respectively). Free protein S functional activity was no different between subgroups (105% [48-230] in anti-ProtS positive vs. 123% [95-283] in anti-ProtS negative vs. 136% [60-174] in controls).Anti-ProtS are frequent in SLE patients with thrombosis and pregnancy morbidity. These antibodies do not interfere with free protein S in plasma since its level and/or functional activity are not impaired.

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Engelberger, Rolf P., Verena Schroeder, Michael Nagler, Raja Prince, Daniel Périard, Daniel Hayoz i Nils Kucher. "Enhanced Thrombolysis by Ultrasound-Assisted Catheter-Directed Thrombolysis and Microbubbles in an In Vitro Model of Iliofemoral Deep Vein Thrombosis". Thrombosis and Haemostasis 119, nr 07 (5.06.2019): 1094–101. http://dx.doi.org/10.1055/s-0039-1688973.

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There is a need to improve the efficacy and safety of catheter-directed thrombolysis (CDT) for thrombo-occlusive diseases, and ultrasound-assisted CDT (USAT) is a promising approach. We tested if thrombolysis efficacy of USAT can be improved by adding gaseous microbubbles (MB). We developed an in vitro dynamic overflow model for iliofemoral deep vein thrombosis, and added MB to an USAT system with ultrasound energy and dose of tissue plasminogen activator according to clinical practice. A total of 64 clots (mean baseline weight of 8.23 ± 1.12 g, generated from citrated human whole blood from 7 healthy male volunteers) were randomly assigned to 1 of 4 study protocols of 30 minutes' duration: negative control, CDT, USAT, and USAT + MB.Thrombolysis efficacy was assessed by measuring the change in D-dimer levels in the overflow liquid and the percentage of clot weight reduction. Compared to negative control, change in D-dimer increased by 62% (p = 0.017), 128% (p = 0.002), and 177% (p < 0.001) in the CDT, USAT, and USAT + MB groups, respectively. D-dimer increase was greater in the USAT than in the CDT group (p = 0.014), and greater in the USAT + MB than in the USAT group (p = 0.033). Compared to negative control, percentage of clot weight reduction increased by 123% (p = 0.016), 154% (p = 0.002), and 233% (p < 0.001) in the CDT, USAT, and USAT + MB groups, respectively. Percentage of clot weight reduction was greatest in the USAT + MB group (p < 0.05 compared with all other groups). In conclusion, our in vitro study suggests that the thrombolytic efficacy of USAT in human whole blood clots can be improved by local administration of MB.

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Fan, Priscilla Weiping, Stephen F. Burns i Jason Kai Wei Lee. "Efficacy of Ingesting an Oral Rehydration Solution after Exercise on Fluid Balance and Endurance Performance". Nutrients 12, nr 12 (15.12.2020): 3826. http://dx.doi.org/10.3390/nu12123826.

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This study investigated the efficacy of ingesting an oral rehydration solution (DD) that has a high electrolyte concentration after exercise on fluid balance and cycling performance in comparison with a sports drink (SD) and water (WA). Nine healthy males aged 24 ± 2 years (mean ± SD), with peak oxygen uptake (VO2 peak) 55 ± 6 mL·kg−1·min−1 completed three experimental trials in a randomised manner ingesting WA, SD (carbohydrates: 62 g·L−1, sodium: 31 ± 3 mmol·L−1) or DD (carbohydrates: 33 g·L−1, sodium: 60 ± 3 mmol·L−1). On all trials, fluid was ingested during 75 min cycling at 65% VO2 peak (temperature: 30.4 ± 0.3 °C, relative humidity: 76 ± 1%, simulated wind speed: 8.0 ± 0.6 m·s−1) and during 2 h of recovery (temperature: 23.0 ± 1.0 °C, relative humidity: 67 ± 2%), with the total volume equivalent to 150% of sweat loss during the ride. A 45 min pre-load cycling time trial at a 65% VO2 peak followed by a 20 km time trial was conducted after a further 3 h of recovery. Fluid retention was higher with DD (30 ± 15%) than WA (−4 ± 19%; p < 0.001) and SD (10 ± 15%; p = 0.002). Mean ratings of palatability were similar among drinks (WA: 4.25 ± 2.60; SD: 5.61 ± 1.79; DD: 5.40 ± 1.58; p = 0.33). Although time trial performance was similar across all three trials (WA: 2365 ± 321 s; SD: 2252 ± 174 s; DD: 2268 ± 184 s; p = 0.65), the completion time was faster in eight participants with SD and seven participants with DD than with WA. Comparing SD with DD, completion time was reduced in five participants and increased in four participants. DD was more effective at restoring the fluid deficit during recovery from exercise than SD and WA without compromising the drink’s palatability with increased sodium concentration. Most individuals demonstrated better endurance exercise time trial performance with DD and SD than with WA.

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Hubert, Vincent, Antoine Duwat, Romain Deransy, Yazine Mahjoub i Hervé Dupont. "Effect of Simulation Training on Compliance with Difficult Airway Management Algorithms, Technical Ability, and Skills Retention for Emergency Cricothyrotomy". Anesthesiology 120, nr 4 (1.04.2014): 999–1008. http://dx.doi.org/10.1097/aln.0000000000000138.

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Abstract Background: The effectiveness of simulation is rarely evaluated. The aim of this study was to assess the impact of a short training course on the ability of anesthesiology residents to comply with current difficult airway management guidelines. Methods: Twenty-seven third-year anesthesiology residents were assessed on a simulator in a “can’t intubate, can’t ventilate” scenario before the training (the pretest) and then randomly 3, 6, or 12 months after training (the posttest). The scenario was built so that the resident was prompted to perform a cricothyrotomy. Compliance with airway management guidelines and the cricothyrotomy’s duration and technical quality were assessed as a checklist score [0 to 10] and a global rating scale [7 to 35]. Results: After training, all 27 residents (100%) complied with the airway management guidelines, compared with 17 (63%) in the pretest (P < 0.005). In the pretest and the 3-, 6-, and 12-month posttests, the median [range] duration of cricothyrotomy was respectively 117 s [70 to 184], 69 s [43 to 97], 52 s [43 to 76], and 62 s [43 to 74] (P < 0.0001 vs. in the pretest), the median [range] checklist score was 3 [0 to 7], 10 [8 to 10], 9 [6 to 10], and 9 [4 to 10] (P < 0.0001 vs. in the pretest) and the median [range] global rating scale was 12 [7 to 22], 30 [20 to 35], 33 [23 to 35], and 31 [18 to 33] (P < 0.0001 vs. in the pretest). There were no significant differences between performance levels achieved in the 3-, 6-, and 12-month posttests. Conclusion: The training session significantly improved the residents’ compliance with guidelines and their performance of cricothyrotomy.

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Umoe, Duke Emon, Lukpata Felicia, Agba Mathias i Nwakwue C. Ndukaku. "Clients’ Perception of the Role of Transportation to the Hospital and Level of Hospital in Reducing Maternal Mortality in Calabar, Nigeria". Global Journal of Health Science 12, nr 13 (30.11.2020): 165. http://dx.doi.org/10.5539/gjhs.v12n13p165.

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Transportation is vital in accessing healthcare services as well as reducing maternal mortality. This study examined clients’ perception of the role of transportation to the hospital and level of hospital in reducing maternal mortality in Calabar. This study was a cross-section descriptive design. Four (4) research questions were developed for the study. A total of 220 participants were recruited by proportionate sampling technique. Respondents were selected from four clinic days Tuesdays, Wednesdays, Thursdays and Fridays in each visit for a period of two weeks were used for the study. A structured questionnaire was used to collect data. The data were analysed using frequencies and percentages. The finding of the study revealed that: 153 (68%) agreed that good transportation increases the number of times participants go for an antenatal visit. 159 (72%) of the respondents viewed that good roads and vehicles make a journey to the hospital quick and easy. 177 (62%) opined that the best way to visit the hospital is by one’ s car or a taxi drop. 203 (93%) agreed that hospital has skilled midwives and doctors; 153 (70%) agreed that level of the hospital is reflective of low maternal and infant deaths; 159 (72%) agreed that healthcare team are highly skilled in handling both complicated and uncomplicated deliveries. 181 (78%) supports the notion that transportation plays a huge role in the reduction of maternal mortality in Calabar; 148 (67%) agreed that good road network has an indirect role in reducing maternal mortality in Calabar; 146 (67%) opined that controlled traffic helps reduced maternal mortality in Calabar, and 159 (71%) agreed that lack of access to transport for women in labour can increase stillbirth and maternal death rates. The study concludes that a good road network should be provided to reduce maternal mortality in Calabar.

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Mangel, Joy, Lori Laudenbach, Sheila Schembri, Lawrence Jardine i Reinhard Lohmann. "DDAVP at a Maximal Dose of 15 ug Administered Subcutaneously Is a Safe and Effective Alternative to 20 ug IV for Patients > 50 kg with von Willebrand Disease or Mild Hemophilia A." Blood 106, nr 11 (16.11.2005): 1793. http://dx.doi.org/10.1182/blood.v106.11.1793.1793.

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Abstract Background: DDAVP (desmopressin) is commonly used for the prophylaxis and treatment of bleeding in patients with mild forms of von Willebrand disease (VWD) and Hemophilia A (HemA). The standard dose is 0.3 ug/kg IV, to a maximum of 20 ug. In 1995, our Bleeding Disorders Program began to use a maximum dose of 15 ug both for DDAVP challenges and for therapeutic purposes. This dosing change was triggered by the new availability of 15 ug (1 ml) vials of DDAVP. We also switched to subcutaneous administration rather than intravenous, given the smaller volume (1 ml), and the body of evidence supporting this route of administration (De Sio et al, Thrombosis and Hemostasis1985; 54:387–9). With this strategy, patients weighing <50 kg continue to receive a weight-based dose, but those weighing ≥ 50 kg receive 15ug. Method: In order to evaluate this new dosing regimen, a retrospective review was performed of 62 patients with VWD (n=36) or mild hemophilia (n=26) weighing ≥ 50kg who underwent DDAVP challenges using a 15 ug s/c dose of DDAVP. Data was also collected on the 9 patients (5 VWD, 4 HemA) tested prior to 1995 who received 20 ug IV of DDAVP. Results: Levels of von Willebrand factor antigen (vWFag), ristocetin cofactor activity (RCof) and factor VIII (FVIII) were measured immediately prior to and 1 hour after administration of DDAVP. In the VWD patients (14M, 22F), median baseline levels of vWFag, RCof and FVIII were 31, 27 and 45 U/ml respectively, and rose to a median of 93, 90 and 177 U/ml following a 15 ug dose of DDAVP. This resulted in a median increase of 64 for vWFag (range 0–180), 55 for RCof (24–191) and 121 for FVIII (21–237). Results were comparable in the 5 pts who received 20 ug doses of DDAVP, achieving median increases of 77 (range 17–125), 53 (40–91) and 98 (79–184) respectively. In the HemA patients (19M, 7F), median baseline level of FVIII was 23 U/ml, and rose to a median of 57 U/ml following 15 ug DDAVP. Median increase in FVIII levels was 33 U/ml (range 2–108). These results compare favorably to the 4 patients who received 20 ug DDAVP and achieved a median FVIII increase of 19 U/ml (range 9–60). Chart review identified 26 patients (14 VWD, 12 HemA) who successfully received 15 ug doses of DDAVP in 44 clinical settings, either for the treatment of an acute bleeding episode or as prophylaxis prior to a planned surgical or dental procedure. Conclusions: DDAVP given subcutaneously to a maximum dose of 15 ug appears to be a safe and effective alternative to 20 ug IV for pts > 50 kg with VWD or mild hemophilia A.

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Agustina, Titien, Wida Gerhana i Sulaiman ,. "The Effect of Locus of Control, Learning, and Adversity Quotient towards Micro Business Success (Study on Entrepreneurship under Foster Group of the Banjarmasin Regional Government)". Journal of Wetlands Environmental Management 8, nr 1 (18.02.2020): 21. http://dx.doi.org/10.20527/jwem.v8i1.215.

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Egan, A., P. Sivasothy, R. Gore, M. Martinez Del-Pero, C. Owen, L. Willcocks, R. Smith, S. Burns i D. Jayne. "AB0470 EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS (EGPA) - ONE-YEAR FOLLOW-UP STUDY USING MEPOLIZUMAB ANTI-IL5 THERAPY AS A STEROID SPARING THERAPEUTIC APPROACH". Annals of the Rheumatic Diseases 79, Suppl 1 (czerwiec 2020): 1533–34. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6555.

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Background:EGPA is a small vessel vasculitis characterised by the presence of tissue eosinophilia, necrotising vasculitis and granulomatous inflammation1. Typically, a prodromal asthmatic phase, leads to an eosinophilic stage, which can evolve to include the presence of vasculitis with renal manifestations. In the recent randomised, placebo-controlled MIRRA trial for relapsing and refractory EGPA, adjuvant therapy with anti-IL5 mAB Mepolizumab [MEPO] at 300mg s/c monthly, accrued longer times in remission, reduced steroid exposure and reduced relapse rates2.Objectives:The aim of our study was to analyse the response and outcome for EGPA patients who received 100mg s/c of MEPO monthly for a minimum of 52 weeks, with particular focus on the steroid minimisation benefits.Methods:This retrospective, descriptive study analysed 13 patients with EGPA, who received 100mg s/m monthly MEPO therapy under the eosinophilic asthma care-pathway. Time points of assessment included MEPO commencement [M0] and 12 [M12] months.Results:Table 1.EGPA patients receiving Mepolizumab therapy for one year [100mg s/c]DemographicsAll [n=13]Gender ratio M/F4M:9FANCA positive/ negativeANCA: 3MPO, 1 PR3 positive/ 9 ANCA negativeAge of diagnosis of asthma35 yrs [IQR 28.5-40]Age of diagnosis of EGPA47 yrs [IQR 43.5-53.5]Median age51 yrs [IQR 47.5- 60.5]EGPA disease characteristicsN=13 [%]Asthma 13 [100]Serum eosinophilia or biopsy evidence [N= 12] 12 [100]Pulmonary infiltrates, non-fixed 8[61.5]Neuropathy, mono/poly 4[30.7]Sino-nasal abnormality 12[92.3]Glomerulonephritis 3[23]Cardiovascular 4[30.7]Prior ImmunosuppressantsN=13 [%]Steroids13[100%]Cyclophosphamide 6[46%]Rituximab6[46%]Azathioprine10[77%]Mycophenolate mofetil8[62%]Methotrexate4[31%]Campath 1[7%]Response to therapyM0 [%] Post M12 [%]Prednisolone dose N= 13Mean ±SD 18.925 mg ±11.44 10.575mg ± 5.85Eosinophil count X109/L N=13Mean ±SD 0.415mg ±0.25 0.035±0.039Asthma Control Questionnaire [ACQ] N=5Mean ±SD 2.92 ±1.27 1.31± 0.79BVAS N= 13Mean ±SD 7.307±6.29 2.2307±1.69Creatinine N=9Mean ±SD 68.44±15.03 69.11±17.84Continuation of anti-IL5 therapy N=13 12/13 [92.3%]Conclusion:The relapsing nature of EGPA places a potential dependency of therapy on steroids for asthmatic and vasculitic flares. This underscores the importance of targeted pathway specific biologic therapy to minimise steroid exposure, prevent tissue damage and ensure early response to therapy. This study demonstrates that anti-IL5 serves as a favourable model with steroid minimisation, improvement in asthma control questionnaire, reduction in BVAS and eosinophil counts at the 100mg s/c dosage. ANCA positive serology normalised in all four patients, independent of subtype. Well tolerated, it demonstrated considerable clinical benefit, with 12 patients [92.3%] continuing anti-IL5 therapy beyond 12 months.Long term plan > 12 monthsN=13 [%] Current Months Adjuvant therapy 12M1 Continue15 Aza2 Switched Benralizumab 26 MMF [+], IVIG [-]3 Continue 184 Switched Benralizumab 145 Discontinued Rituximab 12 MTX6 Continue 147 Continue 24 MMF Reduced8 Continue 18 MTX [+]9 Continue 15 MMF [-]10 Continue 1411 Continue 1312 Continue 13 Aza13 Continue 12References:[1]J.C.Jenette,et alRevised International Chapel Hil Consensus Conference Nomenclature of Vasculitides.65, 1–11 (2013).[2]Wechsler, M. E.et al.Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis.N. Engl. J. Med.376, 1921–1932 (2017).Disclosure of Interests:Allyson Egan: None declared, pasupathy Sivasothy: None declared, Robin Gore: None declared, Marcos Martinez Del-Pero: None declared, Caroline Owen: None declared, Lisa Willcocks: None declared, Rona Smith: None declared, Stella Burns: None declared, David Jayne Grant/research support from: ChemoCentryx, GSK, Roche/Genentech, Sanofi-Genzyme, Consultant of: Astra-Zeneca, ChemoCentryx, GSK, InflaRx, Takeda, Insmed, Chugai, Boehringer-Ingelheim

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Książki na temat "184 s 177/.62"

Plato. Liside. Pisa: ETS, 2005.

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Plato. Lysis. Say Yayinlari, 2013.

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Plato. Lysis. ReadHowYouWant.com, Limited, 2006.

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Części książek na temat "184 s 177/.62"

"as product of cultural influences Young, E.H. and Lee, R.M. 16, 89, 175; racist right/legitimate 104 mainstream connections 177; Young, M. 27, 36 research into 174–8, 179 youth/crime relationship: choosing Whitewash project 174–8 interviewees 66–8; negative rhetoric Whyte, W.F. 10, 14, 115, 149 concerning 64–5; and payment for Wilkinson, S. and Kitzinger, C. 95, 99 interviews 67–8; research strategy Williams, T. et al. 11 65–6; study concerning 62–3 Willis, P. 45 Wirth, L. 10, 14, 115 Zellner, W. 151 Wolf, D.R. 181 Zeskind, L. 151 Woollett, A. 100 Zonabend, F. 77 Wright Mills, C. 93 Zorbaugh, H.W. 14". W Danger in the Field, 222. Routledge, 2002. http://dx.doi.org/10.4324/9780203136119-43.

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"Rogers, G. 101 Snow, D. and Bedford, R. 151 Rowe, W. and Schelling, V. 136 Social Work and Criminal Justice 62 Social Work Research Centre (SWRC) safety 197–8; basic measures for 70; 62 designing studies for 62–3; ensuring Song, M. and Parker, D. 169 200–2; in the field 191; interview Speier, M. 149 precautions 65–6; personal Spradley, J. 149 provision for 80–1; and the Stacey, J. 108 researcher 69 Stanley, L. 16, 94, 104; and Wise, S. Said, E. 174 32, 57, 94–5, 107, 143 Santo Domingo festival: commercial Stanton, B. 151 dimension 136; costume and Staples, C. and Mauss, A. 151 greasing 136–7; danger in 133–4; Steier, F. 93 described 134–7; emotional danger at 141–2; equestrian parades 140–1; Temple, B. 100 ethical danger at 142–4; indigenous Thompson, J. 152 culture/European Catholicism in Tilly, C. 151 135–6; levels of participation in Touraine, A. 151 137–40; male/female participation Trejos Ubau, B. 134 in 138–40; meaning of icons in Turner, B.S. 32 134–5; outsider/participant Turner, R. and Killian, L. 151 relationship 133; physical danger at Uildriks, N. and van Mastrigt, H. 28, 137–42; watching/watched roles in 40 142–3 University of Stirling 62 Scarce, R. 18–19, 200 urban plunges 182, 192–3 Scientology movement 22–3, 43 Scott, A. 32 Van Maanen, J. 38–9, 58 Scott, S. 19, 20, 21–2; and Porter, M. 102 Walklate, S. 33 Scottish Office 62 Wallis, R. 17, 22–3, 43 Shaffir, W.B. 100; and Stebbins, R. 149, Walsh, D. 39 152 Warren, C.A.B. 12, 102 Sharrock, W. 58 Wax, M. 199 Shilling, C. 32 Weber, M. 93 Short, J.F. and Wolfgang, M.E. 58 Westmarland, L. 26 Skeggs, B. 108 whiteness: endangered 172–4; ethnic Slack, R. 56 dimension 174, 176; fascist elements Sluka, J.A. 28, 55, 64 176–7; liberal progressive views Smelser, N. 151 178; politically strategic role of Smith, D.J. 107; and Gray, J. 31 174–5; problems concerning 175–6;". W Danger in the Field, 221. Routledge, 2002. http://dx.doi.org/10.4324/9780203136119-42.

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"Mars, G. 55 testing of researcher in 125–6; value Mason, J. 63 of work in 124–6 Maynard, M. 32, 101 Meerabeau, L. 100 Oakley, A. 15, 94, 97 methodologies: autobiography 21; Okely, J. 94, 96; and Callaway, H. 96 collective memory 21; covert Opie, A. 101 17–18, 46–7, 56, 164, 169–70, Owens, D. 100 198–9; desk work/fieldwork balance 57; disengagement 122; Parker, C. 134, 135, 138 formal interviews 170; in-depth Patrick, J. 58 interviews 117; interest in 92–3; Payne, G. et al. 92 non-participant 117; participant Pearson, G. 35, 64 observation 21, 34–6, 39, 137–40, Peritore, N.P. 28 142–4, 170–1; physical danger 3, 8–9, 43, 61–2, 132, qualitative/quantitative 13, 14, 21, 147, 203; in communities under 23, 61–2, 87, 115, 117, 129–30, threat 11; experience of 74–81; and 147, 149; reflexive 12, 16, 56–7, extremism 156, 163; gender 89, 114, 116, 143, 144; symbolic 20 dynamics of 12; and health 11–12; Milgram, S. 17 intimidation/destabilisation 137; Morgan, D. 18, 38, 57 negotiation of 67–8; and Morris, S. 45 participant-observer role 137–40; Mungham, G. 50 participant/researcher sharing of Mykhalovskiy, E. 108 12–13; personal 11–12; preparation for/anticipation of 69–70, 72; National Front 56 reduction in 62–3; at religious New Religious Movements (NRMs) festival 137–42; on the streets 148, 150, 153, 154, 162, 163 10–11; threat of 68; vs psychological New Reproductive Technologies 184–6; and vulnerability of (NRTs) 92 researcher 63–4 nursing home 114–15; as policing 26–7, 40–1; and bouncers 48, alien/unsettling 118; 49, 51; and cult of masculinity 31; contamination/escape from 126–7; danger 26, 27–9, 32; and danger emotional strains in 123–4; initial from above 37–9; enduring emotional responses to 118–23; fieldwork in 29–32; and fear 32, membership issues 119–23; negative 33–7; and gender identity 26, 27, feelings for 126–7; punishment 28, 33–4, 40; and group solidarity strategies 121–2; researcher/staff 27; insider/outsider relationship interaction 119–20; setting of 117; 27–8, 35, 38, 40; and local staff/patient interaction 119, population 34–6; and protectiveness 121–2, 125; structure of 118; and 28–9, 36; research sites 27; seeing". W Danger in the Field, 219. Routledge, 2002. http://dx.doi.org/10.4324/9780203136119-40.

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"Collins, P. 98 structure of 150–1, 152; overt Collinson, D. 58 research on 153–4; and potentials of Community Care 62 confrontation 153–8, 163; reasons Community Relations Councils 171 for studying 158–60; researcher as Cotterill, P. 95, 101, 108; and threat to 154–5; risk of research on Letherby, G. 94, 95, 107 162–3; risk to researcher 153–8; role of researcher in 161–2; Dalley, G. 117 secondary roles for researcher in danger: awareness of 2, 23–4; beyond 155–6; structural/cultural view of researcher/researched 160–2; 151–2; studying 147–8; and trust coping strategies 144; defined 74; in 155–6; validity of research on the field 182; as immediate physical 159–60; and wider community threat 8–9; insights from 189; 160–2; see also groups invisible 80–1; move from empathy Day, G. 107 to sympathy 154–5, 157, 159, 160; Dees, M. and Fiffer, S. 151 multiple aspects 54–5, 133; new delivery suite: attitude to patients agenda 115–18; and political 86–7; description of 81; emotional correctness 169; as positively danger in 82–7; and internal disruptive influence 56; of examination 82–3; and (lack of) representation 168, 179; and knowledge 84–5; and monitoring of research 27–9, 40, 189–92; and births 83–4; and new technology researcher risk 1–7, 9–10, 61; of 81, 85; powerlessness and anger in unreliable knowledge 169; see also 83 risk/danger Denby, S. and Baker, C. 58 dangerous groups 169; acceptance of Denizen, N. 149 researcher in 157; attitude to Dobie, K. 151 presentation of reports on 157–8; door work 43–4, 198–9; assaults, take-basic preparations for studying overs, swimming lessons 48–9; and 163–4; conceptual approach toward the bouncer self 53; and collective 150–2; and confidentiality of trust 51–2; at dance-oriented club material 155–6; covert research on 49–52; and danger 47–53, 54; 153; and data collection 149–50; ethnographic episodes 7–52; at gay defined 148; development of 152; club 48–9; and gender 45, 58; and ethical problems with 156; gaining knowing the score 49–50; links to access to 155; and involvement of criminality 44, 45–6; and losing wider community 160–2; and law ‘bottle’ 48; methodological enforcement 156–7; leadership of concerns 46–7; mythology/reality 156–7; long-term involvement with concerning 44; and personal 156; mechanics of participant information 52; post-fieldwork observation 154; membership/social experience 54–6;". W Danger in the Field, 216. Routledge, 2002. http://dx.doi.org/10.4324/9780203136119-37.

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"professionalisation/regulation of 17–18; in door work 54; and 44–6; and quiet before the storm informed consent 17; and 50–1; regulation/professionalisation misconstruction of research 18; and of 45; visits and vests 49–52 power disparities 19–20; and Douglas, M. 181 protection of participants 18–19; at Durkheim, E. 73 religious festival 142–4 ethics 55, 56, 81, 129, 147; Economic and Social Research Council implications of covert work 43; in (ESRC) 62 practice 15, 17 Ekern, S. 139 extremism see dangerous groups emotional danger 4–5, 8, 9, 72–3, 114–15, 132, 202–3; and Fairhurst, E. 116 auto/biography 91; Farrington, D.P. 65 avoidance/denial of situation 87; feminist theory: intellectual aspect 95; and avoidance/inclusion of feelings and personal experience 94–5; 14–15; coping with 88–90, 128; simplistic view of 95–6 effect on everyday/taken-for-Fielding, N. 10, 56 granted meanings of lives 13–14; Finch, J. 15, 97 and gender 101–2, 104; and Fineman, S. 89 interview process 101–3; learning Fountain, J. 36 from 127–9; and Frank, A. 32 participant/researcher relationship Friedman, K.E. 181 13, 15–16; and personal experience 81–7, 86, 88; and personal interest Gabriel, J. 152, 173 73–4; in policing 32; positive Game, A. and Metcalfe, A. 57 aspects 87–8; and pressure/effect Garfinkel, H. 58 upon researcher 16; recognition of Geertz, C. 160 89; reflections on 85–7; at religious gender 97; and autobiography 107–8; festival 141–2; risk of 100–5; and and bouncers 45, 58; and danger in support systems 103–4 the field 182; and display of emotions: and caring work 116–18; emotions 101–2, 104; and feminist discomforting 117; as distressing research 16; participation in 123–4; importance of personal religious festival 138–40; and role/participation 127–9; initial physical threat 12; in public/private responses 118–23; making sense of places 189–90 123–7; personal 116–17; gender identity: and fitting in with prioritising 129–30 cultural milieu 38–9; and ethical danger 5–6, 8, 9, 132, 156, insider/outsider status 39; and 169–70, 199–200; and (anti)-racist male/female tasks 33–4; and police movements 19; and covert studies work 26, 27, 28, 33–4, 40". W Danger in the Field, 217. Routledge, 2002. http://dx.doi.org/10.4324/9780203136119-38.

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Streszczenia konferencji na temat "184 s 177/.62"

Riedel, F., J. Heil, R. Mahdi, U. Nitz, M. Moderow, M. Golatta, B. Schäfgen i in. "Chemotherapie-Anwendung beim frühen Mammakarzinom in Deutschland – aktuelle Daten aus 179 Brustkrebszentren (2008 – 2015)". W 62. Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe – DGGG'18. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1671630.

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Kornberg, A., S. Kaufman, L. Silber i J. Ishay. "THE EFFECT OF THE VENOM OF THE ORIENTAL HORNET ON COAGULATION FACTORS". W XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644338.

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The extract from the venom sac of Vespa orientalis (VSE) inactivates exogenous and endogenous thromboplastin (Joshua and Ishay, Toxicon, 13:11-20,1975). The prolongation of both prothrombin time (PT) and recalcification time suggests inactivation of other factors. The aim of the present study is to investigate the effect of VSE on clotting factors. A lyophilized VSE with protein concentration of 5 mg/ml was used. Studies were performed in vitro with human plasma and in vivo in cats. Routine methods were employed for the assay of PT, activated tissue thromboplastin (APTT), thrombin time (TT), fibrinogen degradation products (FDP), fibrinogen and factors V,VII,VIII,IX,X. Human plasma was incubated with various concentrations of VSE (0,1,5,10,50,100 μg/ml) for 60 min and for various incubation times (0,5,15,30,+ 60,90,120 min) with 50 μg/ml VSE (n=8). 1 μg/ml VSE prolonged PT from 13.5 to 16 sec (p<0.05) and APTT from 62 to 180 sec. PT was maximal (17.7 sec) with 10 μg/ml and APTT (442 sec) with 50 μg/ml VSE. Factors V,VII,X decreased gradually from 94-105% to 11%,11% and 29% with 100 μg/ml VSE and VIII and IX to 1% even with 1 μg/ml VSE. After 5 min with constant concentration of VSE (50 μg/ml) PT was 14.9 sec (normal 13 sec) and APTT 165 sec (normal 54 sec). Both were maximal (17.5 and 298 sec) after 60 min. Factors VII and X decreased to 13% and 32% and VIII and IX to >1% after 60 min of incubation. Injection of 5 mg/kg VSE to cats (n=6-8) resulted in prolongation of PT from 9.4 to 11.2 sec and of APTT from 19.5 to 63 sec after 5 min. Both were maximal after 90 min (12.3 and 127 sec). Factors V,VII and X decreased from 100% to 7.6%, 13% and 37% and VIII and IX to 1% after 10 min. In all experiments TT and plasma fibrinogen were not affected and FDP were normal. Heating of VSE for 5 min at 80°C abolished completely the anticoagulant activity but dialysis for 24 hr at 4°C had no effect on it. The activity was eluted on Sephadex-25 both in void and post void volumes. The results show that VSE has a potent anticoagulant activity against various factors. Factors VIII and IX are markedly decreased. The effect on V, VII and X is moderate. Plasma fibrinogen is not affected. The nature and clinical significance of the anticoagulant activity merit further investigation.

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Zekert, F., A. Hufnagl, A. Hufnagl i M. A. A. Kratzer. "FIRST EXPERIENCE WITH A NEW SYSTEM TO MEASURE PRIMARY HEMOSTASIS IN VITRO". W XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643078.

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Control of hemostatic parameters of patients undergoing surgery usually involves only determination of parameters of the coagulation cascade, but not measurement of primary hemostasis. This has mainly methodological reasons. Recently a model of primary hemostasis has been introduced (Kratzer & Bom, Haemostasis 15:357; 1985) now produced under the name “ Thrombostat 4000” (VDG von der Goltz, 8221 Seeon, West Germany). This device measures computerized within minutes “ in vitro” bleeding parameters (vBP) like bleeding volume (V,ul), time (T,sec) and the viscosity depending initial flow (IF,ul/min) in a small sample (0.5-lml) of whole anticoagulated blood (Na citrate 1 to 10). The clinical relevance of the vBP was tested in patients undergoing major surgery.Results : Case 1: A 78 years old woman with osteomyelosarcoma, heavy bleeding and normal coagulation parametrs showed strongly pathological vBP: (V > 800, T > 300, IF 184); control values: (V = 177, T = 105, IF = 145); An improvement of beeding and shortening of vBP was observed after infusion of platelet concentrate: (V = 328, T = 245, IF = 147).Case 2: A 60 years old man with adenocarcinoma undergoing liver transplantation, before operation (OP) vBP: (V = 224, T = 114, IF = 182); displayed a strong increase during OP: (V > 800, T = 360, IF = 277; decreasing values after Oft (V = 348, T = 146, IF = 254); 1. day after OP: (V = 250, T = 127, IF = 221); 13 day after OP normal vBft (V = 160, T = 111, IF 182).Case 3: A 35 years old man with III. grade burnings of the skin (35%) and a massive platelet function defect: (V > 800, T > 180, IF = 328); improvement after infusion of platelet concentrate: (V = 393, T = 164, IF = 239); further improvement some hours later: (V = 240, T = 120, IF = 213); and normalizing of parameters at the 1. day: (V = 197, T = 126, IF = 186) and the 5. day after OP: (V = 130, T = 122, IF = 142).It is interesting to note that patients with heavy burnings reguarly displayed reduced vBP: (V = 120, T = 70, IF = 127) if measured very early after the accident. The new method seems to be a valuable instrument to judge platelet functions.

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