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Gotowa bibliografia na temat „153.9/3/09”

Autor: Grafiati
Data publikacji: 25 lipca 2024
Data aktualizacji: 26 lipca 2024

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Artykuły w czasopismach na temat "153.9/3/09"

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Medra, A. "S3-09 SESSION 3". Plastic and Reconstructive Surgery - Global Open 7 (sierpień 2019): 35. http://dx.doi.org/10.1097/01.gox.0000582924.89158.85.

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Ouyang, Wenjun, Ellen Filvaroff, Yan Hu i Jane Grogan. "Cover Picture: Eur. J. Immunol. 3/09". European Journal of Immunology 39, nr 3 (marzec 2009): 622. http://dx.doi.org/10.1002/eji.200990010.

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Hardianti, Sri. "Gambaran Kualitas Hidup pada Lansia di Perumahan Graha Mustamindo 3 RT.09 Desa Rimbo Panjang". ANTHOR: Education and Learning Journal 2, nr 2 (22.03.2023): 256–61. http://dx.doi.org/10.31004/anthor.v2i2.123.

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Adapun tujuan dari penelitian ini adalah untuk mengetahui Gambaran Kualitas Hidup Lansia diPerumahan Graha Mustamindo 3 Rt. 09 Desa Rimbo Panjang. Pendekatan pada penelitian iniadalah deskriptif yaitu metode yang bertujuan untuk mengetahui gambaran kualitas hidup lansia di Perumahan Graha Mustamindo 3 Rt. 09 Desa Rimbo Panjang. Penelitian ini dilaksanakan padabulan Desember sampai Januari 2022. Penelitian ini dilaksanakan di Perumahan Graha Mustamindo 3 Rt. 09 Desa Rimbo Panjang dengan pertimbangan bahwa Perumahan GrahaMustamindo 3 Rt. 09 tersebut merupakan daerah yang banyak lansia. Populasi dalam penelitianini adalah seluruh Lansia yang ada di Perumahan Graha Mustamindo 3 Rt. 09 Desa Rimbo Panjang yaitu sebanyak 35 KK. jumlah sampel dalam penelitian adalah 35 responden agar dapatmenggambarkan kualitas hidup pada lansia di Perumahan Graha Mustamindo 3 Rt. 09 DesaRimbo Panjang. Teknik pengambilan sampel pada penelitian ini adalah sampling jenuh yaitumengambil semua anggota populasi menjadi sampel. Penelitian ini merupakan deskriptif dimana data penelitian didapat dengan membagikan kuesioner kepada 35 orang lansia di Perumahan Graha Mustamindo 3 RT 09 Desa Rimbo Panjang. Berdasarkan analisa univariat diperoleh kualitas hidup lansia di Perumahan Graha Mustamindo 3 RT 09 Desa Rimbo Panjang sebanyak 28 lansia (76,5%) mempersepsikan kualitas hidupnya baik, 5 lansia (21,0%) mempersepsikan kualitas hidupnya sedang, 1 lansia (1,2%) mempersepsikan kualitas hidupnya buruk, dan 1 lansia (1,2%) mempersepsikan dirinya sangat buruk.
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Santos, M. A., T. Coelho, A. Machado, R. Cerqueira, A. Fernandes i P. Tavares. "N.P.3 09 Hereditary neuropathies in a pediatric clinic". Neuromuscular Disorders 16, nr 9-10 (październik 2006): 666–67. http://dx.doi.org/10.1016/j.nmd.2006.05.085.

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Gargallo, L., J. Vaamonde, R. Ibáñez, M. A. Del Real, A. Hernandez i M. Gudín. "3-09-04 Early focal cerebral injury: Brain plasticity". Journal of the Neurological Sciences 150 (wrzesień 1997): S153. http://dx.doi.org/10.1016/s0022-510x(97)85595-5.

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Brown, T., H. Scarfone, C. Cupido i A. McComas. "3-09-06 Cognitive function and congenital brachial palsy". Journal of the Neurological Sciences 150 (wrzesień 1997): S153. http://dx.doi.org/10.1016/s0022-510x(97)85596-7.

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Chua, H. C., A. K. Y. Tan, C. B. Tan i H. Tjia. "3-17-09 High-dose phenobarbitone in status epilepticus". Journal of the Neurological Sciences 150 (wrzesień 1997): S163. http://dx.doi.org/10.1016/s0022-510x(97)85649-3.

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D, Batsaikhan, Lkhagvasuren N, Bayar-Enkh B, Tsevegdorj Ch, Enkh-Oyun T, Uуen E, Sainbileg G, Chimgee P i Dolgorsuren Ts. "Result of determination placental protein 13 (pp13) and placental growth factor in placental extract of mongolian mares". Mongolian Journal of Agricultural Sciences 25, nr 03 (28.12.2018): 57–65. http://dx.doi.org/10.5564/mjas.v25i03.1172.

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The present study aimed to isolate some proteins from placenta of Mongolian mares and measure their concentrations using ELISA test kits. In order to achieve this aim, a total of 12 variants of protein isolation experiments in triplicates were performed to isolate proteins from each homogenates, which were obtained with 3 methods of tissue homogenizations of placental tissue of Mongolian mare using distilled water, phosphate buffer saline and Tris-HCl, by use of 4 methods of protein extraction and precipitation with distilled water, sulfate ammonium salt and organic solvents such as ethanol and acetone. Molecular weights of proteins isolated using above variants of methods or a total of 36 samples determined by SDS polyacrylamide gel electrophoresis demonstrated the bands of proteins with molecular weights ranging from 1,060 to 26,600 dalton were clearly detected on the electrophoregram, and 1083.9 to 5747.2 μg/ml total proteins in all samples were measured by Pierce BCA assay kit. Results of ELISA measurements of placental protein 13 (PP13) and placental growth factor (PlGF) in samples that PP13 and PlGF concentrations in both extracts, one of which were homogenized in PBS, followed by ethanol precipitation and another, homogenized in distilled water, followed by acetone precipitation were 34.4±9.2 and 34.9±1.3 pg/ml and 469.4±46.9 and 404.7±153.9 pg/ml respectively demonstrated extracts containing higher amounts of biologically active proteins can be obtained by using methods of homogenization of tissues extracted in PBS or distilled water and precipitation with organic solvents. Монгол гүүний эхэсийн ханд бэлтгэж, өсөлтийн хүчин зүйл, 13-р уураг тодорхойлсон дүн Хураангуй: Энэ судалгааны ажлын зорилго нь монгол гүүний эхсийн зарим уургийг ялган авч, ЭЛИЗА-ийн аргаар тодорхойлох явдал байв. Энэхүү зорилгын хүрээнд Монгол гүүний эхсийн эдийг нэрмэл ус, фосфатын буфер, трис-давсны хүчлээр хандлан гомогенжүүлэх 3 аргыг ашиглан, тэдгээрээс гарсан гомогенат тус бүрээс уураг ялгах туршилтыг сульфат аммоний давс, этанол, ацетоноор тундасжуулах, нэрмэл усанд хандлах 4 янзын аргаар уураг ялгасан нийт 12 хувилбарыг тус бүр 3 давталттай хийсэн юм. Дээрх хувилбаруудаар ялган авсан уургууд буюу нийт 36 дээжинд молекул жинг электрофорезийн аргаар тодорхойлоход ихэнх хувилбаруудад 1,060-26,600 дальтон жинтэй уургийн толбууд тод илэрч байсан ба уургийн хэмжээг Пьерсийн цомгоор тодорхойлоход 1083.9-5747.2 мкг/мл уураг илэрсэн юм. Эхсийн өвөрмөц 13-р уураг, эхсийн өсөлтийн хүчин зүйлийн хэмжээг тус тус ЭЛИЗА-ийн аргаар тодорхойлоход фосфатын буферт хандлан гомогенжүүлж, этанолоор тундасжуулсан болон нэрмэл усаар хандлан гомогенжүүлээд ацетоноор тундасжуулсан хувилбаруудад эхсийн 13-р уураг 34.4±9.2 ба 34.9±1.3 пг/мл, өсөлтийн хүчин зүйл 469.4±46.9 ба 404.7±153.9 пг/мл хэмжээтэй байгаа нь фосфатын буфер эсвэл нэрмэл усанд хандлан, гомогенжүүлж, органик уусгагчдаар тундасжуулах замаар биологийн идэвхт уураг илүү их агуулсан ханд бэлтгэх боломжтойг харуулж байна. Түлхүүр үг: Адуу, судаслаг бүрхүүл, 13-р уураг, өсөлтийн хүчин зүйл, тунадасжуулалт,
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Lewis, Kevin M., Jeff McKee, Alexandra Schiviz, Alexander Bauer, Martin Wolfsegger i Andreas Goppelt. "Randomized, Controlled Comparison of Advanced Hemostatic Pads in Hepatic Surgical Models". ISRN Surgery 2014 (4.03.2014): 1–7. http://dx.doi.org/10.1155/2014/930803.

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Blood loss during hepatic surgery leads to poor patient outcomes. This study investigates the hemostatic efficacy of a novel sealing hemostatic pad (polyethylene glycol-coated collagen, PCC) and a fibrin sealant pad (fibrin-thrombin coated collagen, FTC) in a leporine hepatic segmentectomy and a porcine hepatic abrasion model. A segmentectomy was used to compare hemostatic success and hematoma incidence in 20 rabbits (10/group). Hepatic abrasions were used to compare hemostatic success up to 10 min after application in six pigs (42 lesions/group). In the segmentectomy model, PCC achieved 100% hemostatic success within 2 min (95% CI: 72.3% to 100%) and FTC achieved 80% hemostatic success within 3 min (49.0% to 94.3%). PCC had lower hematoma incidence at 15 min (0.0 versus 11.1%) and 24 h (20.0 versus 66.7%). In the abrasion model, PCC provided superior hemostatic success at 3 (odds ratio: 24.8, 95% CI: 8.86 to 69.2, P<0.001), 5 (66.3, 28.5 to 153.9, P<0.001), 7 (177.5, 64.4 to 489.1, P<0.001), and 10 min (777.6, 148.2 to 4078, P<0.001) leading to statistically significant less blood loss. The novel sealing hemostat provides faster and more sustained hemostasis than a fibrin sealant pad in a leporine hepatic segmentectomy and a porcine hepatic abrasion model of hepatic surgery.
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Pittock, SJ, M. Barnett, JL Bennett, A. Berthele, J. de Sèze, M. Levy, I. Nakashima i in. "P.011 Efficacy and safety of ravulizumab in adults with AQP4+ NMOSD: interim analysis from the ongoing phase 3 CHAMPION-NMOSD trial". Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 51, s1 (24.05.2024): S17. http://dx.doi.org/10.1017/cjn.2024.119.

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Background: CHAMPION-NMOSD (NCT04201262) is an ongoing global, open-label, phase 3 study evaluating ravulizumab in AQP4+ NMOSD. Methods: Adult patients received an intravenous, weight-based loading dose of ravulizumab on day 1 and a maintenance dose on day 15 and every 8 weeks thereafter. Following a primary treatment period (PTP; up to 2.5 years), patients could enter a long-term extension (LTE). Results: 58 patients completed the PTP; 56/2 entered/completed the LTE. As of June 16, 2023, median (range) follow-up was 138.4 (11.0-183.1) weeks for ravulizumab (n=58), with 153.9 patient-years. Across the PTP and LTE, no patients had an adjudicated on-trial relapse during ravulizumab treatment. 91.4% (53/58 patients) had stable or improved Hauser Ambulation Index score. 91.4% (53/58 patients) had no clinically important worsening in Expanded Disability Status Scale score. The incidence of treatment-emergent adverse events (TEAEs) and serious adverse events was 94.8% and 25.9%, respectively. Most TEAEs were mild to moderate in severity and unrelated to ravulizumab. TEAEs leading to withdrawal from ravulizumab occurred in 1 patient. Conclusions: Ravulizumab demonstrated long-term clinical benefit in the prevention of relapses in AQP4+ NMOSD with a safety profile consistent with prior analyses.
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Rozprawy doktorskie na temat "153.9/3/09"

1

Marlow, Gregory. "Week 02, Video 09: Animation Part 3". Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/digital-animation-videos-oer/22.

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Marlow, Gregory. "Week 06, Video 09: Bouncing Ball 3". Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/digital-animation-videos-oer/49.

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Cinetto, Francesco. "Glycogen synthase kinase-3 (GSK-3) in the pathogenesis of pulmonary fibrosis: what we know from the mouse model". Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424180.

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Introduction: Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by an aberrant interstitial deposition of collagen in the lung parenchyma, leading to progressive lung function impairment. Repeated injuries to the alveolar epithelium are believed to lead to an imbalance of the extracellular matrix (ECM) turnover supported by metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). The kinase GSK-3 is a mediator of the cytokine homeostasis and favors the production of pro-inflammatory mediators. Its specific inhibitor, SB216763, displayed anti-inflammatory and anti-fibrotic properties of in a mouse model of Bleomycine (BLM)-induced pulmonary fibrosis. Furthermore, GSK-3 seems to be involved in the epithelial to mesenchimal transition (EMT). The purpose of this study was to assess the expression of MMP9, TIMP1, MMP2 and and TIMP2 in the early inflammatory response and in the late fibrosis induced by BLM in a mouse model of pulmonary fibrosis. Next goal was to elucidate whether the in vivo treatment with SB216763 could modulate MMPs activity and their balance with TIMPs. Moreover, in vitro experiments were aimed to identify the signal pathways through which GSK-3 can modulate MMPs and TIMPs. Methods: Cohorts of C57BL6 mice (12 weeks old) were randomized to receive intratracheal instillation of either saline (PBS), or BLM alone, or BLM in association with SB216763. The inhibitor was administered intraperitoneally the day after BLM and every 48 hours up to the sacrifice on day 7 (inflammatory phase) or 28 (fibrotic phase), when bronchoalveolar lavage (BAL) was performed and lungs harvested. MMP9 and MMP2 activity was measured by gel zymography in BAL fluid (BALF). MMPs and TIMPs expression levels were evaluated by Real Time-PCR and Western Blotting. Their tissue localization was evaluated by IHC analysis. In vitro experiments were performed using A549 cells as epithelial model, assessing expression and activity of MMPs downstream of TNFα, with and without GSK-3 silencing by siRNA. Results: MMP9 and MMP2 levels were elevated in BALF from BLM-treated mice at day 7. At this time point, the inflammatory cells recruited in the intra-alveolar spaces were alveolar macrophages (AMs), lymphocytes and neutrophils. Furthermore, the lung IHC staining indicated a strong positivity for MMP9, MMP2, TIMP1 and TIMP2 in interstitial AM (iAM) and, specifically, in injured and cuboidalized epithelium. BLM-treated mice sacrificed at day 28 presented high levels of MMP2 and TIMP1 and low levels of MMP9 in the BALF. Interestingly, in vivo GSK-3 inhibition reduced MMP9, MMP2 and TIMP1 levels in the BALF and their positivity in iAMs and in epithelium. Moreover, in vitro experiments performed with A549 cells, as epithelial model, demonstrated that GSK-3α and GSK-3β silencing increased MMP9 expression after stimulation with the pro-inflammatory cytokine TNFα. This effect was achieved by the interaction of GSK-3 with NF-kB and ERK signalling transduction pathway. Conclusions: Our mouse model of BLM-induced pulmonary fibrosis clearly showed an imbalance between MMPs and TIMPs during inflammation and fibrosis. Importantly, we proposed GSK-3 as a crucial mediator of their expression in AMs and in damaged epithelium. Next, in vitro results with A549 cells suggested that GSK-3 silencing induce MMP-9 secretion, downstream of TNFα, in a p65-mediated and ERK1,2 dependent manner.
Introduzione: La fibrosi polmonare idiopatica (IPF) è un'interstiziopatia caratterizzata da un decorso fatalmente progressivo, che conduce alla completa compromissione della funzione polmonare. Pur essendo la sua patogenesi non pienamente compresa, il primum movens sembra essere un danno epiteliale ripetuto che induce l'aberrante deposizione di matrice extracellulare (ECM), il cui turnover non viene più garantito da metalloproteasi (MMPs) e loro inibitori tissutali (TIMPs). La chinasi GSK-3 è nota per il suo ruolo cardine nella modulazione di citochine pro-infiammatorie ed in diverse vie del segnale e processi cellulari verosimilmente coinvolti nella patogenesi della IPF. La sua inibizione in vivo, in un modello murino di fibrosi polmonare indotta da bleomicina (BLM), si è dimostrata in grado di modulare sia la risposta infiammatoria precoce che la fase fibrotica tardiva. Il ruolo della chinasi nella modulazione dell'equilibrio fra MMPs e TIMPs nella fibrogenesi polmonare non è ad oggi chiarito. Metodi: Diverse coorti di topi C57BL6 sono state sottoposte all'instillazione endotracheale di BLM o PBS e trattate o meno, per via intraperitoneale, con l'inibitore di GSK-3 SB216763. Per misurare attività, espressione proteica e genica delle MMPs sono stati utilizzati, rispettivamente, zimografia, WB analysis e RT-PCR del liquido di lavaggio bronco alveolare (BALF) di topi sacrificati a 7 o 28 giorni dalla somministrazione di BLM. L'espressione proteica e genica delle TIMPs è stata valutata con WB e RT-PCR. E' stata inoltre eseguita l'analisi istologica ed immunoistochimica dei polmoni, ai due intervalli di tempo. L'effetto in vitro del silenziamento di GSK-3 è stato infine studiato su una linea di cellule epiteliali alveolari umane (A549). Risultati: Il trattamento con BLM ha dimostrato di aumentare la cellularità ed i livelli di MMP2 e MMP9 nel BALF al giorno +7. Si è inoltre registrato un significativo aumento dell'espressione di MMP2, MMP9, TIMP1 e TIMP2, all'analisi immunoistochimica, a livello di macrofagi alveolari (iAMs) e cellule epiteliali alveolari cuboidalizzate (CEACs). I topi sacrificati al giorno +28 hanno mostrato un incremento dei livelli di MMP2 e TIMP1, ma non di MMP9, nel BALF. L'inibizione in vivo di GSK-3 mediante SB216763 si è dimostra in grado di ridurre il reclutamento di cellule infiammatorie e la secrezione di MMPs al giorno +7, a livello del BALF; ha inoltre ridotto i livelli di MMP2 al giorno +28. Anche l'espressione di MMPs e TIMPs è stata modulata dall'inibizione di GSK-3, a livello di iAMs e CEACs, ad entrambi gli intervalli di tempo. Gli esperimenti in vitro su A549 hanno invece dimostrato che il silenziamento di GSK-3 è in grado di potenziare la secrezione di MMP9 indotta dallo stimolo proinflammatorio con TNFa, che attiva la via di NF-kB. Conclusioni: Il nostro lavoro dimostra un ruolo di GSK-3 nella modulazione dell'espressione di MMPs e TIMPs in un modello murino di fibrosi polmonare indotta da BLM, che interessa sia la fase infiammatoria precoce che quella fibrotica tardiva. L'effetto dell'inibizione di GSK-3 sembra esplicarsi, in particolare, a livello di iAMs e CEACs. I dati in vitro, pur preliminari, indicano un effetto opposto del silenziamento di GSK-3 sulla secrezione di MMP9 in una linea di cellule epiteliali alveolari (A549); il silenziamento di GSK-3 potenzia l’effetto di TNFα sulla secrezione di MMP-9, tramite un meccanismo che coinvolge p65 ed è ERK1,2-dipendente
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BONZANNI, MATTIA. "THE EXPRESSION OF THE RARE CAVEOLIN-3 VARIANT T78M ALTERS CARDIAC ION CHANNELS FUNCTION AND MEMBRANE EXCITABILITY". Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/546165.

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The identification of new molecular insights always drove the research. Data from genetic, molecular biology and biochemistry suggest new directions, open new fields and lead to new discoveries. The significance of these data is, in certain situation, difficult to envision. In this view, physiology could represent one of the possible read-out of the overall complex modifications inside the cell. In particular, electrophysiological analysis shed light on both physiological and pathological conditions in excitable and non-excitable cells. In excitable cell, ion channels, cellular microenvironment, transcription factors and accessory proteins shape the electric profile of the cell. In my PhD, I mainly used this approach to test the effect of mutations associated with arrhythmic diseases (in both cardiac arrhythmia and epilepsy) and of physiopathological remodeling in response to endurance training. In particular, I performed the following projects concerning: - Characterization of the biophysical properties of the hHCN1 L157V mutation found in a patient affected by idiopathic generalized epilepsy. This mutation resulted to decrease the current density and leading to an increased excitability in single neonatal rat cortical neurons. - Analysis of the cardiac endurance training-associated microRNAs (miRNAs) in a trained mouse model and of the role of the muscle-specific miRNAs in modulating membrane excitability in the neonatal rat ventricular cardiomyocytes. These results highlights new miRNAs potentially involved in the cardiac electrical remodeling associated with endurance training. - Characterization of the impact of the T78M cav-3 variant found in a cohort of arrhythmic patients. This variant induces modification of several ionic currents leading to a pro-arrhythmogenic profile. The leitmotiv of these projects is the identification of the causes underlying the pathophysiological modification of excitable cells by ion channels, membrane proteins and post-transcriptional molecules.
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LISAI, SARA. "Nutritional factors influencing tissue omega-3 metabolism and endocannabinoids levels in experimental models and humans". Doctoral thesis, Università degli Studi di Cagliari, 2016. http://hdl.handle.net/11584/266644.

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The nutritional role of dietary fatty acids is quite controversial and often the object of mediatic campaigns either as panacea against all diseases or detrimental for human health. The most recent data are instead showing that it should be considered, in an optimal dietary regimen, the balance among all dietary fatty acids based on the current physiological needs, applying what it is currently known as personalised nutrition. It has been paid particular attention to the ratio between highly polyunsaturated fatty acids (HPUFAs) n-6, mainly arachidonic acid (ARA, 20:4n-6;) and n-3 HPUFAs, mainly eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3) in tissues, since an inverse correlation between circulating n-3 HPUFAs and several chronic pathological states has been observed, possibly mediated by modulation of the endocannabinoid system (ECS). However, to assess this balance and controlling it by dietary means remains a great challenge for nutritionists. In addition, other nutritional factors may influence their tissue concentration. It is therefore compelling to individuate the mechanism(s) of action and what are the most efficient nutritional conditions to maximize n-3 HPUFAs health-related beneficial activities. The aim of this thesis was to evaluate the effects of some nutritional factors, such as conjugated linoleic acid (CLA), naturally occurring in the diet or produced by the probiotic Bifidobacterium breve (B. breve), in influencing n-3 PUFA metabolism to optimize the n-3 HUFA score (a biomarker of n-3 status in tissues) and possible interactions with the ECS in rodents and humans. We evaluated whether CLA, from different dietary sources, was able to enhance DHA biosynthesis, from its precursor alpha linolenic (ALA), in experimental models and humans. We found that different dietary ALA/CLA ratios affected n-3 PUFA and EC profile with a graded decrease of ALA and EPA and corresponding increase of DHA, while the EC arachidonoylethanolamine (AEA) decreased parallel to ratio ALA/CLA, whereas dietary ALA, in absence of CLA, was not able to increase significantly circulating DHA levels. We also evaluated whether supplementation with B. Breve as probiotic, along with ALA, in mice, as a nutritional factor that may increase dietary CLA, modulated n-3 fatty acid metabolism. We found that dietary probiotics increased DHA biosynthesis in liver and epididymal adipose tissue. Actually, we showed an increased of DHA biosynthesis in liver, but not an increase of CLA, while the ratio CD 16:2/CLA, a biomarker of peroxisomal beta oxidation, increased significantly but not associated to a higher PPAR α gene expression. The observed parameters suggested that these effects may be related to a pro-inflammatory event possibly triggered by the activation of toll like receptors by B. breve. In fact, in an ancillary experiment on rats challenged with LPS, we obtained similar results on fatty acid metabolism. In addition, dietary probiotics decreased AEA and its congener palmitoylethanolamine (PEA) levels in liver, while in adipose tissue we found a significant increased levels of AEA, PEA and the other AEA congener oleoylethanolamide (OEA). Our studies strongly suggest that background diet may play an important role in modulating fatty acid metabolism and in particular in modulating n-3/n-6 fatty acid balance, thereby differently affecting the ECS. Therefore, the synergistic effects of different nutritional factors, as it occurs in daily life in humans are somewhat difficult to predict and may explain the contradictory results in the literature on the effects of dietary fatty acids, in particular when they are singularly considered without taking into account the whole dietary regimen. The discover that gut microbiota may directly interfere and modify fatty acid metabolism opens to novel nutritional strategies in shaping the optimal milieu for contrasting several metabolic disorders by modulating the ECS. Future studies in humans will be focus on evaluating possible synergistic effects of CLA-enriched products with B. breve in maintaining and/or re-equilibrating energy and lipid metabolism, by modulating EC and congeners tissue profile, acting on energy metabolism and EPA and DHA related molecules, and also to assess if there is an optimal level of dietary EPA and DHA to allow a synergistic activity in different physio-pathological conditions.
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Plotegher, Nicoletta. "Unraveling the mechanisms of alpha-synuclein aggregation and toxicity". Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423061.

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Parkinson’s disease is the second most common neurodegenerative disorder after Alzheimer’s disease and affects about 1% of the population over 65 years old. This disorder can be both sporadic and familial and some genetic forms are due to mutations in SNCA gene, encoding for the protein alpha-synuclein (aS). PD pathological hallmarks are the prominent death of the dopaminergic neurons in the substantia nigra pars compacta and the presence of proteins and lipid inclusions, termed Lewy’s body (LBs), in the surviving neurons in parkinsonian brains. The main constituent of LBs is an aggregated fibrillar beta-sheet rich form of aS. aS aggregation process was widely studied in the past years: the protein is unfolded in its native state, but in pathological conditions it tends to aggregate forming oligomeric species. These oligomers constitute a heterogeneous and transient ensemble and rapidly convert into amyloid fibrils when they reach a critical concentration. Amyloid fibrils then deposit in LBs along with several other proteins and lipids. aS aggregation was mainly studied in vitro, but recently more efforts were put into the study of this process in cell and animal models, to identify not only aS aggregation intermediates, but also the associated toxic mechanism(s) that lead to neurons cell death in PD. In this thesis two main issues were faced: the study of aS aggregation in cells using unconventional methods and the characterization of the effects of the family of chaperone-like proteins 14-3-3, on aS aggregation. In the first part, two cellular models for the study of aS aggregation were set and characterized: the first one is obtained just overexpressing aS and allowed the characterization of an ensemble of heterogeneous oligomeric species (about 6±4 monomers per oligomer) using a new fluorescence microscopy method termed Number and Brightness analysis. These oligomeric species induced autophagic lysosomal pathway activation and mitochondrial fragmentation in this model. The second cellular model provides a method to study aS fibrils and larger aggregates in a physiological environment: aS was overexpressed in cells and aggregation was triggered by introducing in cell cytoplasm recombinant aS fibrils fragments, termed seeds. In both cases aS overexpression and aggregation cause cellular death, in good agreement with what was previously published by others groups. The characterization of aS aggregation in cells went further looking at the variation in cellular metabolism, possibly induced by mitochondrial damage. These changes were quantified measuring NADH fluorescence properties in the two models with respect to the control. These results showed that in cells presenting aS oligomer or aggregates, NADH fluorescence lifetime and emission spectra change, suggesting that these measurements may be used to detect aS aggregates in live cells and in vivo using a non-invasive dye-free method. The second part of the thesis concerns the ability of 14-3-3 chaperone-like proteins of interacting with aS and of interfering with aS aggregation process rescuing the induced toxicity in cells. Among the seven 14-3-3 isoforms, 14-3-3 eta can re-route aS amyloidogenic process in vitro, leading to the formation of curved objects rather than aS fibrils. These curved objects have diameters and curvatures that depend on 14-3-3 eta amount in the aggregation assays; moreover, 14-3-3 eta molecules were found in these aggregates, suggesting the formation of a stable complex between the two proteins. When aS amount is too large or seeds are used to trigger the aggregation process in vitro, 14-3-3 eta is not able any more to affect aS aggregation and is sequestered into aS fibrils. In cell models, 14-3-3 eta overexpression leads to a rescue when aS was only overexpressed, but not when aggregation in cell cytoplasm was triggered by seeds. Overexpressed 14-3-3 eta was found to interact with overexpressed aS using image correlation spectroscopy methods (cross raster image correlation spectroscopy and cross Number and Brightness analysis), mainly at plasma membrane. Moreover, 14-3-3 eta is sequestered into aggregates when aS aggregation is triggered by seeds, highlighting another possible toxic mechanism due to aS aggregation. All the results obtained in cells are in good agreement with the in vitro results previously reported, further suggesting that 14-3-3 proteins and eta isoform in particular are interesting in aS aggregation frame and may be used to interfere in the process to rescue its toxic effects.
La malattina di Parkinson è la seconda malattia neurodegenerative più comune dopo il morbo di Alzheimer e colpisce circa l’1% delle popolazione sopra i 65 anni di età. Questa malattia può essere sia sporadica che familiare e alcune forme genetiche sono dovute a mutazioni nel gene SNCA che codifica per la proteina alfa-sinucleina. Le caratteristiche patologiche principali della malattia di Parkinson sono la morte prevalentemente dei neuroni dopaminergici della substantia nigra pars compacta e la presentza di inclusioni proteiche e lipidiche, dette corpi di Lewy, nei neuroni che sopravvivono nei cervelli dei pazienti affetti dalla malattia. Il componente principale dei corpi di Lewy è una forma di alfa-sinucleina aggregata, fibrillare e ricca di foglietti beta. Il processo di aggregazione di alfa-sinucleina è stato ampiamente studiato negli anni passati: la proteina è non strutturata nella sua forma nativa, ma in condizioni patologiche tende ad aggregare formando specie oligomeriche. Questi oligomeri costituiscono un insieme etereogeneo e transiente e si convertono rapidamente in fibrille amiloidi quando raggiungono una concentrazione critica. Le fibrille amiloidi di alfa-sinucleina si depositano poi nei corpi di Lewy assieme ad altre proteine e lipidi. L’aggregazione di alfa-sinucleina è stata principalmente studiata in vitro, anche se più recentemente maggiori sforzi sono stati effettuati per caratterizzare il processo in modelli cellulari ed animali, per identificare non soltanto i diversi prodotti dell’aggregazione, ma anche i meccanismi tossici ad essi associati, che causano la morte dei neuroni nei pazienti affetti dalla malattia di Parkinson. In questa tesi due questioni principali sono state affrontate: lo studio dell’aggregazione di alfa-sinucleina in cellule utilizzando metodi non convenzionali di microscopia in fluorescenza e la caratterizzazione degli effetti di una famiglia di proteine chaperoniche, le 14-3-3, sul processo di aggregazione. Nella prima parte, due modelli cellulari per lo studio dell’aggregazione di alfa-sinucleina sono stati approntati e caratterizzati: il primo viene ottenuto sovraesprimento soltanto alfa-sinucleina e ha permesso la caratterizzazione di un ensemble di oligomeri eterogenei in cellule vive (circa 6±4 monomeri per oligomero) utilizzando un nuovo metodo di microscopia in fluorescenza chiamato Number and Brightness analysis. Queste specie oligomeriche inducono l’attivazione del sistema autofagico-lisosomiale e la frammentazione dei mitocondri in questo modello cellulare. Il secondo modello cellulare fornisce un metodo per lo studio delle fibrille di alfa-sinucleina e di aggregati più grandi in un ambiente di rilevanza fisiologica: alfa-sinucleina è stata sovrespressa in cellule e l’aggregazione è stata promossa introducendo nel citoplasma delle cellule frammenti di fibrille ottenute da alfa-sinucleina ricombinante, detti seeds. In entrambi i casi la sovraespressione e l’aggregazione di alfa-sinucleina hanno causato morte cellulare, in buon accordo con quello che è stato riportato in precedenza da altri gruppi di ricerca. La caratterizzazione dell’aggregazione di alfa-sinucleina in cellule è continuata osservando la variazione nel metabolismo cellulare, potenzialmente indotta da danni ai mitocondri. Queste variazione sono state quantificate misurando le proprietà della fluorescenza del NADH nei due modelli, rispetto al controllo. Questi risultati hanno mostrato che in cellule che presentano oligomeri o aggregati di alfa-sinucleina, il tempo di vita della fluorescenza del NADH e il suo spettro di emissione cambiano. Quindi, queste misure potrebbero essere ottimizzare per rilevare la presenza di aggregati di alfa-sinucleina in cellule e in vivo, utilizzando un metodo di indagine non invasivo e dye-free. La seconda parte della tesi riguarda l’abilità delle proteine chaperoniche 14-3-3 di interagire con alfa-sinucleina e di interferire con il suo processo di aggregazione, riducendone la tossicità in cellule. Tra le sette isoforme della famiglia di 14-3-3, la 14-3-3 eta può revertire il processo di fibrillazione di alfa-sinucleina in vitro, portando alla formazione di oggetti curvi invece che di fibrille canoniche. Questi oggetti curvi hanno diametri e curvature che dipendono dalla quantità di 14-3-3 eta nel saggio di aggregazione: inoltre, molecole di 14-3-3 eta sono state trovate in questi aggregati, suggerendo la formazione di un complesso stabile costituito dalle due proteine. Quanto la quantità di alfa-sinucleina è troppo grande o i seeds vengono utilizzati per promuovere il processo di aggregazione in vitro, la 14-3-3 eta non è più in grado di interferire con il processo di aggregazione di alfa-sinucleina e viene sequestrata nelle fibrille. Nei modelli cellulari, la sovraespressione di 14-3-3 eta riduce la tossicità indotta da alfa-sinucleina quando quest’ultima è soltato sovraespressa e oligomerizza, ma non quando l’aggregazione in cellule viene promossa dai seeds. È stato mostrato, utilizzando tecniche di image correlation spectroscopy (cross raster image correlation spectroscopy e cross Number and Brightness analysis) che la 14-3-3 eta sovraespressa può interagire con alfa-sinucleina sovraespressa, principalmente alla membrana plasmatica. Inoltre, la 14-3-3 eta viene sequestrata negli aggregati quando il processo di aggregazione di alfa-sinucleina è indotto dai seeds, evidenziando un altro possibile meccanismo di tossicità dovuto all’aggregazione. Tutti i risultati ottenuti in cellule sono in buon accordo con i risultati ottenuti in vitro e precedentemente riportati; questo rafforza ulteriormente l’idea che le proteine 14-3-3 e in particolare l’isoforma eta siano particolarmente interessanti nel contesto dello studio dell’aggregazione di alfa-sinucleina e che potrebbero essere utilizzare per interferire con il processo di aggregazione e ridurne gli effetti tossici.
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Meggiolaro, Silvia. "Comparison of a 3-dimensional model and standard radiographic evaluation of femoral and tibial angles in the dog". Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3427216.

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Bone deformities are a common problem in veterinary medicine. These problems are frequently related to the main hind limb pathologies that commonly affect our animals, such as hip dypslasia, cranial cruciate ligament rupture and patellar luxation. It has been demonstrated that a precise and accurate preoperative planning is crucial to the success of the corrective surgeries. The assessment of hind limb deformities has been studied in the past years and up till now there is still a lot of confusion in understanding what could be the best method to apply for a correct evaluation of the deformity. Several methods have been suggested to measure femoral and tibial angles, some studies suggested even an assessment using computed tomography and magnetic resonance imaging. During the last years new methods combining traditional images with reverse engineering technique have been suggested too but although the use of different techniques have been described, radiographic measurement still represents the most common method used for the interpretation of hind limb deformities. This study aimed to compare a 3-dimensional model with standard radiographic evaluation of femoral and tibial angles. Cadavers of eight adult dogs, deceased for reason unrelated to this study, were obtained. Radiographs were obtained using four standard projections: an elevated-torso/hip-extended radiograph, a mediolateral radiograph of the femur, a caudocranial view of the stifle joint and a mediolateral radiograph of the stifle. All radiographs included in the study were made by two single individuals and reviewed and approved in terms of quality and positiong by three different examiners. Evaluation of the neck-shaft angle, the aLPFA, mLPFA, aMDFA and mMDFA, the angle of version and the varus angle for the femur and of the mMPTA, mMDTA and MAD for the tibia, was performed applying the main methods available in literature. After femoral and stifle radiographs were made of each cadaver, the femurs and tibia were harvested and freed of all of the soft tissues sparing the articular cartilage. Every bone was then scanned to create a 3-dimensional computed model. Using RAPIDFORM 2006 (Inus Technology INC.) we could manipulate the shell to evaluate all of the angles previously determined in the 2-dimensional model. The average error in assessing mLPFA , mMDFA , mMPTA and mMDTA, was less than 5% comparing the 2-dimensional method with our 3-dimensional model. Based on these findings, we feel that the reported radiographic methodologies and values may be used to diagnose and quantify hindlimb deformities with a good accuracy. aLPFA and aMDFA values were acceptable for three of the four methods and neck-shaft angle was better represented from the combination of Symax method for the neck axis and Kowalesky's method for the anatomic one.
Le deformita' ossee rappresentano un problema relativamente comune in mediacina veterinaria. Queste alterazioni sono frequentemente associate ad alcune delle principali patologie ortopediche dell'arto posteriore che comunemente affliggono i nostri animali, come per esempio la displasia dell'anca, la rottura del legamento crociato craniale e la lussazione di rotula. E' stato dimostrata la necessita' di eseguire planning preoperatori accurati e precisi, cio' risulta fondamentale per il successo di eventuali chirurgie correttive. Le principali linee guida per la misurazione delle deviazioni ossee sono state studiate nel corso degli anni e ad oggi persiste un ampio dibattito su quale possa essere considerato il metodo migliore per una valutazione delle deformita'. Sono stati suggeriti diversi metodi per la misura degli angoli femorali e tibiali, alcuni lavori suggeriscono l'impiego di tac e risonanza magnetica. Durante gli ultimi anni sono stati proposti metodi innovativi che combinano le metodologie tradizionali con l'impiego di elaborati software ingegneristici per la rielaborazione delle immagini e creazione di modelli tridimensionali. Nonostante sia stato suggerito l'impego di diverse tecniche, nel panorama odierno la radiografia continua a rappresentare il metodo piu' comunemente utilizzato per l'interpretazione delle deformita' scheletriche dell'arto posteriore. Questo studio vuole confrontare un modello 3-dimensionale e il metodo radiografico standard nella valutazione degli angoli femorali e tibiali. Sono stati ottenuti otto cadaveri di cani adulti, deceduti per cause esterne allo studio. Tutti i soggetti sono stati sottoposti a studio radiografico di entrambi gli arti posteriori, eseguendo quattro proiezioni standard: una proiezione ventrodorsale “a cane seduto”, una proiezione mediolaterale del femore, una caudocraniale ed una mediolaterale del ginocchio e della gamba. Tutte le radiografie incluse nel presente studio sono state selezionate in termini di qualita' e posizionamento da tre diversi operatori. E' stata quidi eseguita la valutazione dell'angolo cervico-diafisario, dell'aLPFA, mLPFA e mMDFA, l'angolo di versione e l'angolo di varismo femorale per il femore, e dell'angolo mMPTA, mMDTA e MAD, per la tibia, utilizzando alcuni dei principali metodi descritti in letteratura. Dopo l'esecuzione delle proiezioni radiografiche, sono stati scheletrizzati i femori e le tibie risparmiando la cartilagine articolare. L'immagine di ogni osso e' stata quindi acquisita tramite l'impiego di uno scanner per creare successivamente un modello tridimensionale. Usando il programma RAPIDFORM 2006 (Inus Technology INC.) abbiamo potuto lavorare con il nostro modello per valutare tutti I valori precedentemente calcolati nell'immagine radiografica. L'errore medio nella valutazione del mLPFA , mMDFA , mMPTA and mMDTA, e' stato inferiore al 5% confrontando il modello bidimensionale con quello tridimensionale. Basandoci su questi risultati ci sentiamo di suggerire che le metodologie radiografiche descritte possono essere utilizzate per diagnosticare e quantificare le deformita' degli arti posteriori con una buona accuratezza. I valori ottenuti per gli angli aLPFA e aMDFA sono stati accettabili in tre dei quettro metodi applicati mentre il metodo che meglio ha rappresentato l'angolo crevico-diafisario e' risultato dalla combinazione dell'utilizzo dell'asse cervicale Symax con l'anatomico di Kowalesky . I metodi utilizzati per il calcolo degli angoli di varismo femorale, verione e MAD sono risultati non accettabili con un valore del parametro p significativamente > 0.1 in tutti I casi.
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GUEDES, Marcos André Santos. "Perícias Judiciais na 2ª Vara do Trabalho de Aracaju/Se: Possibilidades de Contribuição da ISO 11228-3 e do Decreto Nº 6.957/09 Para o Nexo Causal da LER/DORT". Universidade Federal de Pernambuco, 2015. https://repositorio.ufpe.br/handle/123456789/15560.

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Submitted by Haroudo Xavier Filho (haroudo.xavierfo@ufpe.br) on 2016-03-01T14:28:49Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Mestrado - Ergonomia - Marcos Andre Santos Guedes.pdf: 1525587 bytes, checksum: d619f9d6aa02837679dba4ab3ea38ccf (MD5)
Made available in DSpace on 2016-03-01T14:28:49Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Mestrado - Ergonomia - Marcos Andre Santos Guedes.pdf: 1525587 bytes, checksum: d619f9d6aa02837679dba4ab3ea38ccf (MD5) Previous issue date: 2015-02-23
A sentença em muitos dos processos judiciais trabalhistas envolvendo lides provocadas por patologias pertencentes ao grupo LER/DORT são tomadas mediante a produção de prova pericial que além de se tratar de uma matéria de grande complexidade exigindo olhares multidisciplinares, ainda se defronta com questões como a formação profissional do perito nomeado e diretrizes a serem utilizadas como metodologia investigativa. Devido a esses fatores e a necessidade de evitar laudos periciais imprecisos procurou-se analisar possibilidades de auxílio na fase de reconhecimento de nexo causal a partir da adoção da norma ISO 11228-3 e do Decreto 6.957/09 utilizando-se de processos judiciais trabalhistas oriundos da intranet da 2ª Vara do Trabalho em Sergipe e de pesquisas praticadas na biblioteca digital da CAPES e do portal Google Acadêmico. As análises técnicas mostraram-se favoráveis a implantação da norma e do decreto como recurso auxiliar quando no enquadramento de nexo causalpor LER/DORT. A simulação do uso do decreto nos casos analisados revelou aumento no reconhecimento destas patologias ocupacionais em três vezes quando comparada as conclusões na íntegra produzidas pelo corpo pericial. Apenas um perito judicial possui formação de Pós-graduação na área de ergonomia. Disto confere ao Decreto 6.957/09 e a ISO 11228-3 valor como recurso auxiliar técnico em perícias judiciais de LER/DORT.
The sentence in many of the labor lawsuits involving labors caused by diseases belonging to the group LER/DORT are made by expert evidence production that besides it is a matter of great complexity requiring multidisciplinary looks, still faces issues such as training professional appointed expert and guidelines to be used as research methodology. Due to these factors and the need to avoid inaccurate expert reports sought to examine aid opportunities in the causal nexus of recognition phase with the adoption of ISO 11228-3 and Decree 6.957/09 using labor lawsuits arising intranet 2nd Labor Court in Sergipe and research practiced in the digital library and CAPES Scholar portal. Technical analysis showed their support for implementation of the standard and the decree as auxiliary resource when the nexus of causal framework for LER/DORT. The simulation of the use of the decree in the cases analyzed showed an increase in the recognition of these occupational diseases by three times compared to the conclusions in full produced by the expert body. Only one legal expert has Postgraduate training in ergonomics area. This gives the Decree 6,957 / 09 and ISO 11228-3 value as a resource technical assistant in legal expertise of RSI / MSDs.
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Ahrent, Agnes. "Vems intresse väger tyngst vid oskälighetsbedömningen? : En jämförelse mellan 36 § AvtL och 12 kap. 3 § ÄktB, med utgångspunkt i HD:s dom 2020-07-09 i mål nr T 1413–19". Thesis, Stockholms universitet, Juridiska institutionen, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-191842.

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Villar, Eula Bianca Joves. "Architecting Purpose-Driven Improvisation towards Organizational Effectiveness in Extreme Environments: Case Narratives from Organizations during Typhoon Haiyan". Doctoral thesis, Universitat Ramon Llull, 2018. http://hdl.handle.net/10803/664391.

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Aquesta dissertació doctoral es centra en les discussions acadèmiques que afecten a l'organització de processos en entorns de desastre. En particular, la recerca principal és ‘de quina manera la interacció dels atributs a nivell individual i col·lectiu de les accions improvisades de les organitzacions expliquen com aconsegueixen els seus objectius, p.e. ser eficaços, en contextos extrems?'. Fent servir una estratègia metodològica d’estudis de casos, emergeixen narratives de dos perfils d'organitzacions que eren crítiques per a la fase de resposta i de recuperació del Tifó Haiyan del 2013. La contribució principal d’aquest treball té dos vessants. Primer, es proposa que la improvisació, malgrat la seva naturalesa emergent, està guiada per un propòsit concret, doncs facilita a les organitzacions aconseguir els seus objectius preestablerts. Això succeeix a través de dos efectes: (a) l'efecte buffering, i (b) l'efecte connection-seeking. Segon, s’infereix que les improvisacions amb un propòsit concret estan promogudes per diverses narracions que interaccionen a nivell individual i col·lectiu. Tres narracions sorgeixen: (a) una interacció complementària entre els atributs a nivell individual i col·lectiu, on tots dos, l'individual i l'organitzatiu juguen una funció similar per promoure una improvisació amb un propòsit concret (b) una interacció gestionada a nivell individual, en que l’acció individual apareix més pronunciada en la decisió d'improvisar a nivell de cada propòsit concret, i (c) una interacció que s’adhereix la norma, on el paper de l'organització precedeix la posició individual en la decisió d'improvisar en el propòsit concret.
Esta disertación doctoral se sitúa la discusión académica que afecta a la organización de procesos en entornos de desastre. En particular, la investigación principal es ‘de qué manera la interacción de los atributos a nivel individual y colectivo de las acciones improvisadas de las organizaciones explican cómo pueden esas alcanzar sus objetivos, i.e. ser eficaz, en contextos extremos?' Utilizando una estrategia metodológica de estudio de casos, emergen narrativas de dos perfiles de organizaciones que fueron críticas en la fase de respuesta y de recuperación del Tifón Haiyan del 2013. La contribución principal del trabajo tiene dos vertientes. Primero, se propone que la improvisación, a pesar de su naturaleza emergente, está guiada por propósito concreto, ya que facilita a las organizaciones conseguir sus objetivos preestablecidos. Esto ocurre a través de dos efectos: (a) el efecto buffering, y (b) el efecto connection-seeking. Segundo, se infiere que una improvisación con propósito concreto está promovida por varias narrativas de interacción a nivel individual y colectivo. Surgen tres narrativas: (a) una interacción complementaria entre los atributos a nivel individual y colectivo, donde ambos, el individual y la organización juegan una función similar al promover la improvisación con propósito concreto (b) una interacción gestionada a nivel individual, en que la acción individual resulta más pronunciada en la decisión de improvisar con propósito concreto, y (c) una interacción que se adhiere a la norma, en que el rol de la organización precede la posición individual en la decisión de improvisar con un propósito concreto.
This dissertation positions itself within the scholarly conversations on organizing processes in disaster environments. In particular, the main research inquiry is ‘how does the interaction of individual and collective level attributes among improvised actions of the organizations explain how they can realize their goals, i.e. be effective, in extreme contexts?’. Using a case strategy approach, it surfaces narratives of two profiles of organizations that were critical to the response and recovery phase of the 2013 Typhoon Haiyan. The main contribution of the work is two-fold: First, it infers that improvisation, despite its emergent nature, is purpose-driven, as it allows organizations to consciously realize their pre-established goals. This occurs through two effects: (a) the buffering effect, and (b) the connection-seeking effect. Second, it infers that purpose-driven improvisation is enabled by various narratives of interaction between the individual and collective level attributes. Three narratives are emergent: (a) a complementary interaction between the individual- and collective-level attributes, where both the individual and the organization play an equal role in enabling purpose-driven improvisation (b) an individually-maneuvered interaction, where the individual positionality is more pronounced in the enactment of purpose-driven improvisation, and (c) rule-abiding interaction, where the role of the organization precedes the individual positionality in the enactment of purpose-driven improvisation.
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Książki na temat "153.9/3/09"

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International Conference on Computing Anticipatory Systems (9th 2009 Liège, Belgium). Computing anticipatory systems: CASYS'09 - ninth International Conference, Liège, Belgium, 3-8 August 2009. Redaktor Dubois D. M. Melville, N.Y: American Institute of Physics, 2010.

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EuroSys (Conference) (4th 2009 Nuremberg, Germany). EuroSys' 09: Proceedings of the Fourth EuroSys Conference, Nuremberg, Germany, April 1- 3, 2009. New York: Association for Computing Machinery (ACM), 2009.

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1959-, Beuransah Adnan, i Indonesia. Kejaksaan Negeri (Banda Aceh), red. Surat dakwaan nomor reg. perk. 09/SUBVERSI/3/1991 atas nama terdakwa Drs. Adnan Beuransah ... [Banda Aceh]: Kejaksaan Negeri Banda Aceh, 1991.

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Meller, Harald, H. R. Bork i Renate Gerlach. Umweltarchäologie: Naturkatastrophen und Umweltwandel im archäologischen Befund : 3. Mitteldeutscher Archäologentag vom 07. bis 09. Oktober 2010. Halle (Saale): Landesamt für Denkmalpflege und Archäologie Sachsen-Anhalt, Landesmuseum für Vorgeschichte, 2011.

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Asia-Pacific Software Engineering Conference (16th 2009 Batu Ferringhi, Penang, Malaysia). Proceedings: Sixteenth Asia-Pacific Software Engineering Conference : APSEC 09 : 1-3 December 2009, Batu Ferringhi, Penang, Malaysia. Los Alamitos, Calif: IEEE Computer Society, 2009.

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Keller, Felix. Bannwald "Zweribach": Forstbezirk St. Märgen, Wuchsgebiet Schwarzwald, Einzelwuchsbezirk 3/09 Mittlerer Schwarzwald : Erläuterungen zur Forstlichen Grundaufnahme 1999. Freiburg: Forstliche Versuchs- und Forschungsanstalt Baden-Wđurrttemberg, Abt. Botanik und Standortskunde, 2000.

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1959-, Helal Abdelsalam A., Association for Computing Machinery, SIGCHI (Group : U.S.), ACM SIGMOBILE i ACM Digital Library, red. UbiComp '09: Proceedings of the 11th International Conference on Ubiquitous Computing : September 30-October 3, 2009, Orlando, Florida, USA. New York, N.Y: Association for Computing Machinery, 2009.

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Мозгова, Н. Г. Київська духовна академія, 1819-1820: філософський спадок. Київ: Книга, 2004.

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Монтано, Д. Биржи и банки ХХІ столетия: новая волна. Київ: Издательский Дом "Амадей", 2001.

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Гужва, Т. Английские разговорные темы. Київ: Тандем, 1997.

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Części książek na temat "153.9/3/09"

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Mallinson, Jonathan. "3. 1905–09: Experiment and Adversity". W William Moorcroft, Potter, 51–70. Cambridge, UK: Open Book Publishers, 2023. http://dx.doi.org/10.11647/obp.0349.03.

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In the years following success at St Louis, Moorcroft’s designs began to follow two distinct paths: some appealing to the contemporary nostalgia for eighteenth-century elegance, others developing more innovative and experimental ideas. One of his most radical creations, named ‘Flamminian’ ware, reduced ornament to a simple roundel, and focussed attention on form and glaze; it was an uncompromising challenge to the swirling lines of Art Nouveau, and was a great success both at home and in the US. Reviews published in the UK, France and Canada regularly distinguished Moorcroft’s work from much art pottery, underlining the originality of his decorative technique, the quality of his colours, and the integrity of his designs. It is a mark of his growing international reputation that he was invited to write an article for the newly founded American Pottery Gazette. But even as his reputation grew, the first signs of tension with H. Watkin, Director and General Manager at Macintyre’s, can be seen between the lines of reviews in the Pottery Gazette, where Moorcroft’s name was increasingly subordinated to that of Macintyre’s. Factory Minutes show that Watkin was tabling proposals to close down Moorcroft’s department from as early as 1905, to the evident surprise of the other Directors; surviving financial documents suggest that the reason was not the unprofitability of the Ornamental ware, as Watkin would affirm.
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Chun, Ai Lin, Thomas J. Webster i Hicham Fenniri. "Helical Rosette Nanotubes: Topographical and Chemical Roles in Osteoblast Attachment". W Advances in Science and Technology, 1–8. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-09-5.1.

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Gadegaard, Nikolaj, Matthew J. Dalby, Elena Martines, Kris Seunarine, Mathis O. Riehle, Adam S. G. Curtis i Chris D. W. Wilkinson. "Nano Patterned Surfaces for Biomaterial Applications". W Advances in Science and Technology, 107–15. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-09-5.107.

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Beyer, Stefan, Wendy U. Dittmer, Andreas Reuter i Friedrich C. Simmel. "Controlled Release of Thrombin Using Aptamer-Based Nanodevices". W Advances in Science and Technology, 116–21. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-09-5.116.

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Gustavsson, J., G. Altankov, A. Errachid, Josep Samitier, Josep A. Planell i Elisabeth Engel. "Modulation of Biological Properties of Silicon Nitride for Biosensor Applications by Self-Assembled Monolayers". W Advances in Science and Technology, 122–27. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-09-5.122.

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Karlinsey, Robert L., Anderson T. Hara i Clif W. Duhn. "Self-Organized Metal Oxide Exhibiting Enhanced Bioactivity". W Advances in Science and Technology, 17–21. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-09-5.17.

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Malmstadt, Noah, Tae Joon Jeon, Michael Nash, Robert Purnell i Jacob J. Schmidt. "New Approaches to Lipid Bilayer Fabrication: Microfluidic Solvent Extraction and Hydrogel Encapsulation". W Advances in Science and Technology, 22–31. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-09-5.22.

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Zhang, Jing Xian, Mikio Iwasa i Dong Liang Jiang. "Size-Controlled Hydroxyapatite Nanoparticles as Self-Organized Organic-Inorganic Composite Materials". W Advances in Science and Technology, 32–37. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-09-5.32.

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Pegg, E. C., David Farrar, Colin A. Scotchford, Gavin S. Walker i D. M. Grant. "Organic Modification of Titania Sol-Gels and Surfaces". W Advances in Science and Technology, 38–43. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-09-5.38.

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Clark, M. E., C. Engel, P. J. C. Felstead, D. M. Walter, David Farrar, Gavin S. Walker, Colin A. Scotchford i D. M. Grant. "In Vitro Evaluation of Osteoblast and Fibroblast Responses to Precipitated Nano-Particulate Calcium Carbonate". W Advances in Science and Technology, 44–49. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-09-5.44.

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Streszczenia konferencji na temat "153.9/3/09"

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Adomavicius, Gediminas, i Francesco Ricci. "RecSys'09 workshop 3". W the third ACM conference. New York, New York, USA: ACM Press, 2009. http://dx.doi.org/10.1145/1639714.1639806.

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Voutsadakis, Ioannis, i Vanessa Davies. "Abstract P4-09-09: Characteristics of stage 1 to 3 breast cancer patients with amplification of centromere of chromosome 17". W Abstracts: 2019 San Antonio Breast Cancer Symposium; December 10-14, 2019; San Antonio, Texas. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.sabcs19-p4-09-09.

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Jovanovic, B., WJ Ashby, A. Zijlstra, JA Pietenpol i HL Moses. "Abstract P3-05-09: The role of TGF-beta receptor type 3 in breast cancer progression". W Abstracts: Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012; San Antonio, TX. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/0008-5472.sabcs12-p3-05-09.

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Chen, CH, D. Quach, L. Bowers, C. Fabian, S. Hursting i L. deGraffenried. "Abstract P4-09-02: Omega-3 ethyl esters suppress breast cancer growth by modulating inflammatory signaling". W Abstracts: Thirty-Sixth Annual CTRC-AACR San Antonio Breast Cancer Symposium - Dec 10-14, 2013; San Antonio, TX. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/0008-5472.sabcs13-p4-09-02.

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Бондарь, С. С. "Морфо-функциональные взаимосвязи у пациентов с инфекциями нижних отделов респираторного тракта и их идентификация методом активной радиометрии". W ТЕНДЕНЦИИ РАЗВИТИЯ НАУКИ И ОБРАЗОВАНИЯ. «Л-Журнал», 2016. http://dx.doi.org/10.18411/lj2016-3-09.

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Ballesteros, Michael, Erin M. Parker, Erin K. Sauber-Schatz i Likang Xu. "PA 09-3-0747 The burden of non-fatal unintentional drownings in the united states, 2010–2014". W Safety 2018 abstracts. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/injuryprevention-2018-safety.53.

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Lee, SJ, YS Chae, TJ Kwon, JH Chung, J. Lee, JH Jung, WW Kim i in. "Abstract P4-09-21: Dual expression of aquaporin 3 and 5 in patients with early breast cancer". W Abstracts: Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 8-12, 2015; San Antonio, TX. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.sabcs15-p4-09-21.

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Sakata, K., K. Tagomori, N. Sugiyama, S. Sasaki, Y. Shinya, T. Nanbu, Y. Kawashita, I. Narita i H. Miyahara. "Dust Explosion Properties of Aluminum, Titanium, Zinc and Iron Based Alloy Powders Used for Cold Spray". W ITSC2013, redaktorzy R. S. Lima, A. Agarwal, M. M. Hyland, Y. C. Lau, G. Mauer, A. McDonald i F. L. Toma. ASM International, 2013. http://dx.doi.org/10.31399/asm.cp.itsc2013p0190.

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Abstract In this study, the dust explosion properties of aluminum, titanium, zinc, and iron based alloy powders were evaluated by JIS Z 8818: “Test method for minimum explosible concentration of combustible dusts,” IEC 61241-2-3 (1994-09) Section 3: “Method for determining minimum ignition energy in dust-air mixtures,” and JIS Z 8817: “Test method for explosion pressure and rate of pressure rise of combustible dusts.” The test are described and the results are presented and discussed.
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Dorairaj, JJ, N. Miller, J. Newell, MJ Kerin i JB Weidhaas. "P1-09-05: A 3′UTR Functional Variant in BRCA1: A Predictor of Poor Outcome in Breast Cancer." W Abstracts: Thirty-Fourth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 6‐10, 2011; San Antonio, TX. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/0008-5472.sabcs11-p1-09-05.

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Earl, HM, C. Blenkinsop, L. Grybowicz, A.-L. Vallier, DA Cameron, JMS Bartlett, N. Murray i in. "Abstract OT3-3-09: ARTemis trial - randomised trial with neo-adjuvant chemotherapy for patients with early breast cancer". W Abstracts: Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012; San Antonio, TX. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/0008-5472.sabcs12-ot3-3-09.

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Raporty organizacyjne na temat "153.9/3/09"

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Stanton, John F., i Suzanne D. Nakaki. PRESSS Vol. 3-09 - Design Guidelines for Precast Concrete Seismic Structural Systems. Precast/Prestressed Concrete Institute, 2002. http://dx.doi.org/10.15554/pci.rr.seis-011.

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VanRoosen, Hugh. Should Military Governance Guidance Return to its Roots? A Doctrinal Comparison Between Field Manual 27-5 (1943) and Field Manual 3-05.40 (2006)(CSL Student Issue Paper, Volume S02-09, August 2009). Fort Belvoir, VA: Defense Technical Information Center, sierpień 2009. http://dx.doi.org/10.21236/ada509209.

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DOE. Corrective Action Investigation Plan for Corrective Action Unit 406: Area 3 Building 03-74 and Building 03-58 Under ground Discharge Points and Corrective Action Unit 429: Area 3 Building 03-55 and Area 9 Building 09-52 Underground Discharge Points, Tonopah Test Range, Nevada. Office of Scientific and Technical Information (OSTI), maj 1999. http://dx.doi.org/10.2172/9589.

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Johnson, Jeff. Corrective Action Decision Document/Closure Report for Corrective Action Unit 406: Area 3 Building 03-74 & Building 03-58 Underground Discharge Points and Corrective Action Unit 429: Area 3 Building 03-55 & Area 9 Building 09-52 Underground Discharge Points, Tonopah Test Range, Nevada, Revision 0. Office of Scientific and Technical Information (OSTI), marzec 2020. http://dx.doi.org/10.2172/1818286.

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Lynn Kidman. Addendum to the Corrective Action Decision Document/Closure Report for Corrective Action Unit 406: Area 3 Building 03-74 & Building 03-58 Underground Discharge Points and Corrective Action Unit 429: Area 3 Building 03-55 & Area 9 Building 09-52 Underground Discharge Points, Tonopah Test Range, Nevada, Revision 0. Office of Scientific and Technical Information (OSTI), październik 2008. http://dx.doi.org/10.2172/945281.

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US DOE Nevada Operations Office. Record of Technical Change {number_sign}1 for ''Corrective Action Investigation Plan for Corrective Action Unit 406: Area 3 Building 03-74 and Building 03-58 Underground Discharge Points and Corrective Action Unit 429: Area 3 Building 03-55 and Area 9 Building 09-52 Underground Discharge Points, Tonopah Test Range, Nevada'' Revision 0. Office of Scientific and Technical Information (OSTI), czerwiec 1999. http://dx.doi.org/10.2172/751156.

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Raymond, Kara, Laura Palacios i Evan Gwilliam. Status of climate and water resources at Big Bend National Park: Water year 2019. Redaktor Tani Hubbard. National Park Service, wrzesień 2022. http://dx.doi.org/10.36967/2294267.

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Climate and hydrology are major drivers of ecosystem structure and function, particularly in arid and semi-arid ecosystems. Understanding changes in climate, groundwater, streamflow, and water quality is central to assessing the condition of park resources. This report combines data collected on climate, groundwater, and springs at Big Bend National Park (NP) to provide an integrated look at climate and water conditions during water year (WY) 2019 (October 2018–September 2019). However, this report does not address the Rio Grande or its tributaries. Annual precipitation was higher than normal (1981–2010) for Big Bend NP at four of the five National Oceanic and Atmospheric Administration Cooperative Observer Program weather stations: 111% of normal for Chisos Basin, 122% of normal for Panther Junction, 155% of normal for Persimmon Gap, and 124% of normal for Rio Grande Village. Castolon had 88% of normal annual precipitation. All five stations had higher than normal rainfall in October and December, while rainfall totals were substantially below normal at all stations in November, February, and March. Monthly precipitation totals for April through September were more variable from station to station. Mean monthly maximum air temperatures were below normal in the fall months, with Panther Junction as much as 7.5°F below normal in October. Monthly temperatures from January through July were more variable. Temperatures in August and September were warmer than normal at every station, up to +9.4°F at Rio Grande Village and +8.7°F at Chisos Basin in July. The reconnaissance drought index values indicate generally wetter conditions (based on precipitation and evaporative demand) at Chisos Basin since WY2016 and at Panther Junction and Persimmon Gap since WY2015, except for WY2017. This report presents the manual and automatic groundwater monitoring results at nine wells. Five wells had their highest water level in or just before WY2019: Panther Junction #10 peaked at 99.94 ft below ground surface (bgs) in September 2018, Contractor’s Well peaked at 31.43 ft bgs in November 2018, T-3 peaked at 65.39 ft bgs in December 2018, K-Bar #6 Observation Well peaked at 77.78 ft bgs in February 2019, and K-Bar #7 Observation Well peaked at 43.18 ft bgs in February 2019. This was likely in response to above normal rainfall in the later summer and fall 2018. The other monitoring wells did not directly track within-season precipitation. The last measurement at Gallery Well in WY2019 was 18.60 ft bgs. Gallery Well is located 120 feet from the river and closely tracked the Rio Grande stage, generally increasing in late summer or early fall following higher flow events. Water levels in Gambusia Well were consistently very shallow, though the manual well measurement collected in April was 4.25 ft bgs—relatively high for the monitoring record—and occurred outside the normal peak period of later summer and early fall. The last manual measurement taken at TH-10 in WY2019 was 34.80 ft bgs, only 0.45 ft higher than the earliest measurement in 1967, consistent with the lack of directional change in groundwater at this location, and apparently decoupled from within-season precipitation patterns. The last water level reading in WY2019 at Oak Springs #1 was 59.91 ft bgs, indicating an overall decrease of 26.08 ft since the well was dug in 1989. The Southwest Network Collaboration (SWNC) collects data on sentinel springs annually in the late winter and early spring following the network springs monitoring protocol. In WY2019, 18 sentinel site springs were visited at Big Bend NP (February 21, 2019–March 09, 2019). Most springs had relatively few indications of natural and anthropogenic disturbances. Natural disturbances included recent flooding, drying, and wildlife use. Anthropogenic disturbances included flow modifications (e.g., springboxes), hiking trails, and contemporary human use. Crews observed one to seven facultative/obligate wetland plant...
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