Artykuły w czasopismach: „128/.2”

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Lomiento, Liana. "Archil. fr. 128, 2 W.² (= 105, 2 Tard.)". Quaderni Urbinati di Cultura Classica 64, nr 1 (2000): 39. http://dx.doi.org/10.2307/20546623.

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Yang, Yi, i Jinping Zhang. "Mir-128-2 inhibits the development of B cell (HEM1P.218)". Journal of Immunology 194, nr 1_Supplement (1.05.2015): 50.1. http://dx.doi.org/10.4049/jimmunol.194.supp.50.1.

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Abstract Accumulating evidence suggest that miRNAs play important roles in immune system. At present study, we first found that miRNA expression profiles were significantly different among vary immunocytes by microarray. Here, We focused on miR-128-2 which was highly expressed in DP T cells, but lower in other detected cells. In order to further study the function of miR-128-2 in lymphocytes development, we established the miR-128-2 chimeric and transgenic mice, confirmed by FACS analysis and PCR. We found B cell development appeared profoundly defects in both mice models, however, the development of T cells had no significant changes after over-expressing mir-128-2. Further analysis suggest that CLP was significantly higher in mir-128-2 TG mice compared to WT mice, but HSC and MMP cells were comparable in mir-128-2 TG mice and WT mice. Brdu and annexinV staining showed that over-expressing mir-128-2 did not affect the proliferation and apoptosis of CLP. These suggested that miR-128-2 inhibited the CLP cells to develop into B cell. Finally, we try to seek for the targets of miR-128-2 through software analysis and molecular biology methods. We found that miR-128-2 might down-regulate a group of genes including BCL11a, MALT1, A2b et. al. to inhibit B cell development confirmed by luciferase assay, real time PCR and western blot. Thus, our present study suggests that miR-128-2 mainly blocks CLP to differentiate into PreProB cells by down-regulating the BCL11a, MALT, A2b et al. genes.

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Yang, Fengzhen, Qi Zhao, Lipeng Wang, Jinying Wu, Lihua Jiang, Li Sheng, Leyan Zhang, Zhaoping Xue i Maoli Yi. "Diminished Susceptibility to Cefoperazone/Sulbactam and Piperacillin/Tazobactam in Enterobacteriaceae Due to Narrow-Spectrum β-Lactamases as Well as Omp Mutation". Polish Journal of Microbiology 71, nr 2 (1.06.2022): 251–56. http://dx.doi.org/10.33073/pjm-2022-023.

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Abstract Cefoperazone/sulbactam (CSL) and piperacillin/tazobactam (TZP) are commonly used in clinical practice in China because of their excellent antimicrobial activity. CSL and TZP-nonsusceptible Enterobacteriaceae are typically resistant to extended-spectrum cephalosporins such as ceftriaxone (CRO). However, 11 nonrepetitive Enterobacteriaceae strains, which were resistant to CSL and TZP yet susceptible to CRO, were collected from January to December 2020. Antibiotic susceptibility tests and whole-genome sequencing were conducted to elucidate the mechanism for this rare phenotype. Antibiotic susceptibility tests showed that all isolates were amoxicillin/clavulanic-acid resistant and sensitive to ceftazidime, cefepime, cefepime/tazobactam, cefepime/zidebactam, ceftazidime/avibactam, and ceftolozane/tazobactam. Whole-genome sequencing revealed three of seven Klebsiella pneumoniae strains harbored bla SHV-1 only, and four harbored bla SHV-1 and bla TEM-1B. Two Escherichia coli strains carried bla TEM-1B only, while two Klebsiella oxytoca isolates harbored bla OXY-1-3 and bla OXY-1-1, respectively. No mutation in the β-lactamase gene and promoter sequence was found. Outer membrane protein (Omp) gene detection revealed that numerous missense mutations of OmpK36 and OmpK37 were found in all strains of K. pneumoniae. Numerous missense mutations of OmpK36 and OmpK35 and OmpK37 deficiency were found in one K. oxytoca strain, and no OmpK gene was found in the other. No Omp mutations were found in E. coli isolates. These results indicated that narrow spectrum β-lactamases, TEM-1, SHV-1, and OXY-1, alone or in combination with Omp mutation, contributed to the resistance to CSL and TZP in CRO-susceptible Enterobacteriaceae. Antibiotic susceptibility tests Antibiotics Breakpoint, (μg/ml) Klebsiella pneumoniae Escherichia cou Klebriehd axyoca E1 E3 E4 E7 E9 E10 E11 E6 E8 E2 E5 CRO ≤1≥4 ≤0.5 ≤0.5 ≤0.5 ≤0.5 1 ≤0.5 1 ≤0.5 ≤0.5 1 1 CAZ 4 ≥16 1 2 1 4 4 4 4 2 4 1 1 FEP ≤2 216 1 1 0.25 1 2 2 2 0.5 2 1 1 AMC ≤8 ≥32 ≥128 ≥128 ≥128 ≥128 ≥128 ≥128 ≥128 ≥128 ≥128 ≥128 ≥128 CSL ≤16 ≥64 64 64 64 64 ≥128 128 ≥128 64 128 128 ≥128 TZP ≤16 ≥128 ≥256 ≥256 ≥256 ≥256 2256 2256 ≥256 ≥256 ≥256 ≥256 ≥256 FPT ≤2 ≥16 1 0.5 0.06 0.125 2 1 2 0.25 1 0.125 0.25 FPZ ≤2 216 0.25 0.25 0.06 0.125 0.25 0.25 1 0.125 0.25 0.125 0.125 CZA ≤8 216 1 0.5 0.25 0.25 1 0.25 1 0.5 0.5 0.5 0.25 CZT ≤2 28 2 1 0.5 1 2 2 2 1 1 2 2 CROceftriaxone, CAZceftazidime, FEPcefepime, AMC:amoxicillin clavulanic-acid, CSLcefoperazone/sulbactam, TZP:piperadllin/tazobactam, FPT:cefepime tazobactam, FPZ:cefepime/zidebactam, CZA:ceftazidime/avibactam, CZTceftolozane/tazobactam Gene sequencing results Number Strain ST p-Lactamase gene Promoter sequence mutation Omp mutation El Kpn 45 blaSHV-1, blaTEM-lB none OmpK36, OmpK3 7 E3 Kpn 45 blaSHV-1, blaTEM-lB none OmpK36. OmpK3 7 E4 Kpn 2854 blaSHV-1 none OmpK36, OmpK3 7 E7 Kpn 2358 blaSHV-1 - blaTEM-lB none OmpK36, OmpK3 7 E9 Kpn 2358 blaSHV-1. blaTEM-lB none OmpK36. OmpK3 7 E10 Kpn 18 9 blaSHV-1 none OmpK36. OmpK3 7 Ell Kpn 45 blaSHV-1 none OmpK36, OmpK3 7 E6 Eco 88 blaTEM-lB none none ES Eco 409 blaTEM-1B none none E2 Kox 194 blaOXY-1-3 none OmpK36 mutations. OmpK35 and OmpK 37 deficiency E5 Kox 11 blaOXY-1-1 none no OmpK (OmpK3 5, OmpK36 and OmpK37) gene found

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Liu, Ya, Yifan Shi, Dawu Gu, Zhiqiang Zeng, Fengyu Zhao, Wei Li, Zhiqiang Liu i Yang Bao. "Improved Meet-in-the-Middle Attacks on Reduced-Round Kiasu-BC and Joltik-BC". Computer Journal 62, nr 12 (3.07.2019): 1761–76. http://dx.doi.org/10.1093/comjnl/bxz059.

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Abstract Kiasu-BC and Joltik-BC are internal tweakable block ciphers of authenticated encryption algorithms Kiasu and Joltik submitted to the CAESAR competition. Kiasu-BC is a 128-bit block cipher, of which tweak and key sizes are 64 and 128 bits, respectively. Joltik-BC-128 is a 64-bit lightweight block cipher supporting 128 bits tweakey. Its designers recommended the key and tweak sizes are both 64 bits. In this paper, we propose improved meet-in-the-middle attacks on 8-round Kiasu-BC, 9-round and 10-round Joltik-BC-128 by exploiting properties of their structures and using precomputation tables and the differential enumeration. For Kiasu-BC, we build a 5-round distinguisher to attack 8-round Kiasu-BC with $2^{109}$ plaintext–tweaks, $2^{112.8}$ encrytions and $2^{92.91}$ blocks. Compared with previously best known cryptanalytic results on 8-round Kiasu-BC under chosen plaintext attacks, the data and time complexities are reduced by $2^{7}$ and $2^{3.2}$ times, respectively. For the recommended version of Joltik-BC-128, we construct a 6-round distinguisher to attack 9-round Joltik-BC-128 with $2^{53}$ plaintext–tweaks, $2^{56.6}$ encryptions and $2^{52.91}$ blocks, respectively. Compared with previously best known results, the data and time complexities are reduced by $2^7$ and $2^{5.1}$ times, respectively. In addition, we present a 6.5-round distinguisher to attack 10-round Joltik-BC-128 with $2^{53}$ plaintext–tweaks, $2^{101.4}$ encryptions and $2^{76.91}$ blocks.

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Qian, Yilin, Yuan Li, Tengteng Xu, Huijuan Zhao, Mingyong Zeng i Zunying Liu. "Dissecting of the AI-2/LuxS Mediated Growth Characteristics and Bacteriostatic Ability of Lactiplantibacillus plantarum SS-128 by Integration of Transcriptomics and Metabolomics". Foods 11, nr 5 (22.02.2022): 638. http://dx.doi.org/10.3390/foods11050638.

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Lactiplantibacillus plantarum could regulate certain physiological functions through the AI-2/LuxS-mediated quorum sensing (QS) system. To explore the regulation mechanism on the growth characteristics and bacteriostatic ability of L. plantarum SS-128, a luxS mutant was constructed by a two-step homologous recombination. Compared with ΔluxS/SS-128, the metabolites of SS-128 had stronger bacteriostatic ability. The combined analysis of transcriptomics and metabolomics data showed that SS-128 exhibited higher pyruvate metabolic efficiency and energy input, followed by higher LDH level and metabolite overflow compared to ΔluxS/SS-128, resulting in stronger bacteriostatic ability. The absence of luxS induces a regulatory pathway that burdens the cysteine cycle by quantitatively drawing off central metabolic intermediaries. To accommodate this mutations, ΔluxS/SS-128 exhibited lower metabolite overflow and abnormal proliferation. These results demonstrate that the growth characteristic and metabolism of L. plantarum SS-128 are mediated by the AI-2/LuxS QS system, which is a positive regulator involved in food safety. It would be helpful to investigate more bio-preservation control potential of L. plantarum, especially when applied in food industrial biotechnology.

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Ghanim Sulaiman, Alyaa, i Sufyan Salim Mahmood AlDabbagh. "Modified 128-EEA2 Algorithm by Using HISEC Lightweight Block Cipher Algorithm with Improving the Security and Cost Factors". Indonesian Journal of Electrical Engineering and Computer Science 10, nr 1 (1.04.2018): 337. http://dx.doi.org/10.11591/ijeecs.v10.i1.pp337-342.

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128-EEA2 (Evolved Packet System Encryption Algorithm 2) is a confidentiality algorithm which is used to encrypt and decrypt block of data based on confidentiality key. This confidentiality algorithm 128-EEA2 is based on the AES-128 which is the block cipher algorithm of 128 bit in CTR mode. In this paper, we are going to replace the AES-128 block cipher algorithm by HISEC block cipher algorithm for two reasons such as reducing cost and ameliorate security factor.

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Li, Yuan, Taige Liu, Xianghong Meng, Yilin Qian, Shijie Yan i Zunying Liu. "AI-2/Lux-S Quorum Sensing of Lactobacillus plantarum SS-128 Prolongs the Shelf Life of Shrimp (Litopenaeus vannamei): From Myofibril Simulation to Practical Application". Foods 11, nr 15 (29.07.2022): 2273. http://dx.doi.org/10.3390/foods11152273.

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Retarding the protein deterioration of shrimp during storage is important for maintaining its quality. Lactobacillus plantarum SS-128 (L. plantarum SS-128) is a biocontrol bacterium that can effectively maintain the fresh quality of food. This research establishes a myofibril simulation system and refrigerated control system to explore the impact of L. plantarum SS-128 on the quality and shelf life of refrigerated shrimp (Litopenaeus vannamei). Through the bacterial growth assay and AI-2 signal molecule measurement, the effect of the AI-2/LuxS quorum sensing (QS) system of L. plantarum SS-128 and shrimp spoilage bacteria was established. In the myofibril simulation system, a study on protein degradation (dimer tyrosine content, protein solubility, sulfhydryl content, and carbonyl content) showed that adding L. plantarum SS-128 effectively slowed protein degradation by inhibiting the growth of food pathogens. The application to refrigerated shrimp indicated that the total volatile basic nitrogen (TVB-N) value increased more slowly in the group with added L. plantarum SS-128, representing better quality. The total viable count (TVC) and pH results exhibited similar trends. This study provides theoretical support for the application of L. plantarum SS-128 in storing aquatic products.

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8

Abou-Mohamed, G., R. W. Caldwell, T. M. Ibrahim i R. R. Tuttle. "Integrative Cardiovascular Actions of a Novel Catecholamine, GP-2-128". Journal of Cardiovascular Pharmacology 23, nr 3 (marzec 1994): 485–91. http://dx.doi.org/10.1097/00005344-199403000-00019.

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Abou-Mohamed, G., R. W. Caldwell, G. O. Carrier, M. M. Elmazar i R. R. Tuttle. "Interactions of a Novel Catecholamine, GP-2-128, with Adrenoceptors". Journal of Cardiovascular Pharmacology 23, nr 3 (marzec 1994): 492–500. http://dx.doi.org/10.1097/00005344-199403000-00020.

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Abou-Mohamed, G., R. W. Caldwell, T. M. Ibrahim i R. R. Tuttle. "Integrative Cardiovascular Actions of a Novel Catecholamine, GP-2-128". Journal of Cardiovascular Pharmacology 23, nr 3 (marzec 1994): 485–91. http://dx.doi.org/10.1097/00005344-199423030-00019.

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Abou-Mohamed, G., R. W. Caldwell, G. O. Carrier, M. M. Elmazar i R. R. Tuttle. "Interactions of a Novel Catecholamine, GP-2-128, with Adrenoceptors". Journal of Cardiovascular Pharmacology 23, nr 3 (marzec 1994): 492–500. http://dx.doi.org/10.1097/00005344-199423030-00020.

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Khan, Md Aminul Haque, i Rukhsana Parvin. "College News 5(2)". Journal of Enam Medical College 5, nr 2 (29.06.2015): 128–29. http://dx.doi.org/10.3329/jemc.v5i2.23389.

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Kuliopulos, Athan, Paul A. Gurbel, Jeffrey J. Rade, Carey D. Kimmelstiel, Susan E. Turner, Kevin P. Bliden, Elizabeth K. Fletcher, Daniel H. Cox i Lidija Covic. "PAR1 (Protease-Activated Receptor 1) Pepducin Therapy Targeting Myocardial Necrosis in Coronary Artery Disease and Acute Coronary Syndrome Patients Undergoing Cardiac Catheterization". Arteriosclerosis, Thrombosis, and Vascular Biology 40, nr 12 (grudzień 2020): 2990–3003. http://dx.doi.org/10.1161/atvbaha.120.315168.

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Objective: Arterial thrombosis leading to ischemic injury worsens the prognosis of many patients with cardiovascular disease. PZ-128 is a first-in-class pepducin that reversibly inhibits PAR1 (protease-activated receptor 1) on platelets and other vascular cells by targeting the intracellular surface of the receptor. The TRIP-PCI (Thrombin Receptor Inhibitory Pepducin in Percutaneous Coronary Intervention) trial was conducted to assess the safety and efficacy of PZ-128 in patients undergoing cardiac catheterization with intent to perform percutaneous coronary intervention. Approach and Results: In this randomized, double-blind, placebo-controlled, phase 2 trial, 100 patients were randomly assigned (2:1) to receive PZ-128 (0.3 or 0.5 mg/kg), or placebo in a 2-hour infusion initiated just before the start of cardiac catheterization, on top of standard oral antiplatelet therapy. Rates of the primary end point of bleeding were not different between the combined PZ-128 doses (1.6%, 1/62) and placebo group (0%, 0/35). The secondary end points of major adverse coronary events at 30 and 90 days did not significantly differ but were numerically lower in the PZ-128 groups (0% and 2% in the PZ-128 groups, 6% and 6% with placebo, p=0.13, p=0.29, respectively). In the subgroup of patients with elevated baseline cardiac troponin I, the exploratory end point of 30-day major adverse coronary events + myocardial injury showed 83% events in the placebo group versus 31% events in the combined PZ-128 drug groups, an adjusted relative risk of 0.14 (95% CI, 0.02–0.75); P =0.02. Conclusions: In this first-in-patient experience, PZ-128 added to standard antiplatelet therapy appeared to be safe, well tolerated, and potentially reduced periprocedural myonecrosis, thus providing the basis for further clinical trials. Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT02561000.

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Han, Xue, Huafeng Liu i Deyu Zhang. "A System of Two Diophantine Inequalities with Primes". Journal of Mathematics 2021 (15.02.2021): 1–12. http://dx.doi.org/10.1155/2021/6613947.

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Let 1 < d < c < 128 / 119 , 1 < α < β < 6 1 − d / c . In this paper, we prove that there exist positive real numbers N 1 0 and N 2 0 depending on c , d , α , β such that for all real numbers N 1 > N 1 0 , N 2 > N 2 0 and α ≤ N 2 / N 1 d / c ≤ β , the system of two Diophantine inequalities p 1 c + ⋯ + p 6 c − N 1 < N 1 − 1 / c 128 / 119 − c log 109 N 1 , p 1 d + ⋯ + p 6 d − N 2 < N 2 − 1 / d 128 / 119 − d log 109 N 2 is solvable in prime variables p 1 , … , p 6 .

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Khatun, Sabera. "Abstract Vol.32(2)". Bangladesh Journal of Obstetrics & Gynaecology 32, nr 2 (19.07.2020): 128–29. http://dx.doi.org/10.3329/bjog.v32i2.48287.

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Leidlein, Sabryn, Jo-Ann Rammal, Howard Klausner i Jeffrey Johnson. "The Characterization of Trauma Patients Utilizing Private Vehicle Transport (PVT) to the Emergency Department (ED)". Prehospital and Disaster Medicine 38, S1 (maj 2023): s174. http://dx.doi.org/10.1017/s1049023x2300451x.

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Introduction:Existing studies have identified the national rate of PVT for severely injured patients to be 9-16%, our ED has displayed a PVT incidence of 35.4%, suggesting a substantial difference in ED arrival. This study aims to explore descriptive demographics and injury characteristics of patients who arrived by PVT to our ED.Method:A prospective, single-center observational study conducted in Detroit, Michigan. Included patients aged 15 ≥ years who arrived at the ED by PVT for blunt or penetrating trauma. The sample population consisted of 128 patients from August 2019-April 2021. Each subject completed a survey regarding their injury and prehospital care. A retrospective chart review was conducted to acquire information on their injuries.Results:The mean age was 44.3 ± 20.3 years old, range 15-93. 51/128 female, 77/128 male. Patients comprised 93/128 African American, 19/128 Caucasian, 4/128 Asian, 4/128 Hispanic/Latino, and 8/128 other. The most common insurance was Medicaid, comprising 63/128 patients, 25/128 of patients had Medicare and 38/128 had private coverage. Utilizing ESI indices to evaluate severity levels, 73/128 arrived at the ED with an ESI level of 3, 47/128 level of 2, 5/128 level of 4, and 3/128 level of 1, the most severe. Majority of patients 36/128, presented with trauma-related injuries due to a fall. 25/128 presented with a laceration, and 22/128 presented after a motor vehicle crash. The upper extremities were the most common location of trauma 38/128 followed by the lower extremities 23/128. The mean ED length of stay was 11.18 hours.Conclusion:Overall, the findings from this study allowed us to characterize our population of PVT trauma patients through their demographics and injury characteristics. We were able to establish some descriptive characteristics that delineate the population of patients at our ED in Detroit, which is the first step in identifying why trauma patients choose varying modes of transportation.

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Bagus, I. Gede, Agus Yuwono i Erida Wydiamala. "VALIDITAS PEMERIKSAAN GARPU TALA 128 HZ SEBAGAI DETEKSI DIABETIC PERIPHERAL NEUROPATHY PADA PASIEN DIABETES MELITUS TIPE 2 DI RSUD DR. H. MOCH ANSARI SALEH BANJARMASIN". Berkala Kedokteran 13, nr 1 (12.05.2017): 33. http://dx.doi.org/10.20527/jbk.v13i1.3437.

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Abstract: Diabetic peripheral neuropathy (DPN) is one of major complication on uncontrolled diabetes mellitus (DM) patient. Test of 128 Hz tuning fork is a simple test to detect DPN which is recommended by several international guidelines and available at a limited health facility. This research aimed to discover the validity of 128 Hz tuning fork test as diabetic peripheral neuropathy detection on type 2 diabetes mellitus patient at Dr. H. Moch. Ansari Saleh Banjarmasin hospital. This was diagnostic test research with a cross-sectional design. Data was analyzed by using diagnostic test of 2x2 table and receiving operating characteristic (ROC) curve. Subjects were 69 DM outpatient at internal medicine clinic in Dr. H. Moch. Ansari Saleh Banjarmasin hospital. The analysis results were sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and area under the curve. Respectively they were 40%; 100%; 100%; 73,33%; 78,26%; and 70% (0.7) (CI 95%: 55.9%-84.1%). The test of 128 Hz tuning fork has fine validity and can be used as DPN detection on type 2 DM patient. Keywords: Validity, tuning fork 128 Hz test, diabetic peripheral neuropathy, diabetes mellitus Abstrak: Diabetic peripheral neuropathy (DPN) merupakan salah satu komplikasi tersering pada pasien diabetes melitus (DM) yang tidak terkontrol. Pemeriksaan garpu tala 128 Hz adalah salah satu pemeriksaan sederhana untuk mendeteksi DPN yang direkomendasikan oleh beberapa guideline internasional dan dapat dilakukan di fasilitas kesehatan dengan fasilitas terbatas. Penelitian ini bertujuan untuk mengetahui validitas pemeriksaan garpu tala 128 Hz sebagai prosedur deteksi neuropati perifer pada pasien diabetes melitus tipe 2 di RSUD Dr. H. Moch. Ansari Saleh Banjarmasin. Penelitian ini merupakan uji diagnostik dengan pendekatan cross-sectional. Data dianalis dengan uji diagnostik tabel 2x2 dan kurva receiving operating characteristic (ROC). Subjek penelitian merupakan 69 pasien DM rawat jalan poliklinik penyakit dalam RSUD Dr. H. Moch. Ansari Saleh Banjarmasin. Hasil analisis yang didapatkan adalah sensitivitas, spesifisitas, nilai prediktif positif, nilai prediktif negatif, akurasi, dan area under curve dari pemeriksaan garpu tala 128 Hz berturut-turut adalah 40%; 100%; 100%; 74,57%; 78,26%; dan 70% (0.7) (IK 95%: 55.9%-84.1%). Pemeriksaan garpu tala 128 Hz mempunyai validitas yang cukup baik dan dapat digunakan sebagai deteksi DPN pada pasien DM tipe 2. Kata-kata kunci: Validitas, pemeriksaan garpu tala 128 Hz, diabetic peripheral neuropathy, diabetes melitus

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Hoque, Seikh Azimul. "Notes & News vol. 44(2)". Bangladesh Journal of Child Health 44, nr 2 (31.12.2020): 128. http://dx.doi.org/10.3329/bjch.v44i2.51141.

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Chavan, Manoj, Ravish R. Singh i Vinayak Bharadi. "Online signature verification using hybrid wavelet transform". International Journal of Electrical and Computer Engineering (IJECE) 10, nr 2 (1.04.2020): 1823. http://dx.doi.org/10.11591/ijece.v10i2.pp1823-1832.

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Online signature verification is a prominent behavioral biometric trait. It offers many dynamic features along with static two dimensional signature image. In this paper, the Hybrid Wavelet Transform (HWT) was generated using Kronecker product of two orthogonal transform such as DCT, DHT, Haar, Hadamard and Kekre. HWT has the ability to analyze the signal at global as well as local level like wavelet transform. HWT-1 and -2 was applied on the first 128 samples of the pressure parameter and first 16 samples of the output were used as feature vector for signature verification. This feature vector is given to Left to Right HMM classifier to identify the genuine and forged signature. For HWT-1, DCT HAAR offers best FAR and FRR. . For HWT-2, KEKRE 128 offers best FAR and FRR. HWT-1 offers better performance than HWT- 2 in terms of FAR and FRR. As the number of states increase, the performance of the system improves. For HWT - 1, KEKRE 128 offers best performance at 275 symbols whereas for HWT - 2, best performance is at 475 symbols by KEKRE 128.

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Editor. "Answer to Medical Quiz: Images Vol.4(2)". BIRDEM Medical Journal 4, nr 2 (10.11.2014): 128–29. http://dx.doi.org/10.3329/birdem.v4i2.33238.

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Hoque, Seikh Azimul. "Abstract from Current Literatures Vol. 45(2)". Bangladesh Journal of Child Health 45, nr 2 (9.06.2022): 128–29. http://dx.doi.org/10.3329/bjch.v45i2.60124.

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Andre, Walder. "Efficient adaptation of the Karatsuba algorithm for implementing on FPGA very large scale multipliers for cryptographic algorithms". International Journal of Reconfigurable and Embedded Systems (IJRES) 9, nr 3 (1.11.2020): 235. http://dx.doi.org/10.11591/ijres.v9.i3.pp235-241.

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Here, we present a modified version of the Karatsuba algorithm to facilitate the FPGA-based implementation of three signed multipliers: 32-bit × 32-bit, 128-bit x 128-bit, and 512-bit × 512-bit. We also implement the conventional 32-bit × 32-bit multiplier for comparative purposes. The Karatsuba algorithm is preferable for multiplications with very large operands such as 64-bit × 64-bit, 128-bit × 128-bit, 256-bit × 256-bit, 512-bit × 512-bit multipliers and up. Experimental results show that the Karatsuba multiplier uses less hardware in the FPGA compared to the conventional multiplier. The Xilinx xc7k325tfbg900 FPGA using the Genesis 2 development board is used to implement the proposed scheme. The results obtained are promising for applications that require rapid implementation and reconfiguration of cryptographic algorithms.Here, we present a modified version of the Karatsuba algorithm to facilitate the FPGA-based implementation of three signed multipliers: 32-bit × 32-bit, 128-bit x 128-bit, and 512-bit × 512-bit. We also implement the conventional 32-bit × 32-bit multiplier for comparative purposes. The Karatsuba algorithm is preferable for multiplications with very large operands such as 64-bit × 64-bit, 128-bit × 128-bit, 256-bit × 256-bit, 512-bit × 512-bit multipliers and up. Experimental results show that the Karatsuba multiplier uses less hardware in the FPGA compared to the conventional multiplier. The Xilinx xc7k325tfbg900 FPGA using the Genesis 2 development board is used to implement the proposed scheme. The results obtained are promising for applications that require rapid implementation and reconfiguration of cryptographic algorithms.

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Hamilton, Erika Paige, Thierry Petit, Barbara Pistilli, Anthony Goncalves, Ana Alexandra Ferreira, Florence Dalenc, Fatima Cardoso i in. "Clinical activity of MCLA-128 (zenocutuzumab), trastuzumab, and vinorelbine in HER2 amplified metastatic breast cancer (MBC) patients (pts) who had progressed on anti-HER2 ADCs." Journal of Clinical Oncology 38, nr 15_suppl (20.05.2020): 3093. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.3093.

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3093 Background: MCLA-128 (zenocutuzumab ), a HER3 pathway inhibitor, is a humanized bispecific full-length IgG1 antibody targeting both HER2 and HER3 with enhanced ADCC activity. The unique Dock & Block mechanism inhibits HER3 from interacting with its ligands and targets HER2 at a different epitope than trastuzumab, blocking HER2/HER3 dimerization and downstream PI3K/AKT/mTOR signaling. In MBC, HER3 overexpression and/or HER3 ligand upregulation are important drivers leading to trastuzumab resistance, indicating a role for MCLA-128. Preclinical activity was seen in HER2+ breast models when MCLA-128 was combined with trastuzumab. Furthermore, single agent MCLA-128 showed consistent antitumor activity in heavily pretreated HER2+ MBC pts. A phase 2, open-label study explored the MCLA-128/trastuzumab plus vinorelbine triplet in an MBC population. Methods: This open-label trial planned for up to 40 evaluable women with HER2+/amplified MBC progressing on up to 5 anti-HER2 lines including trastuzumab, pertuzumab and an anti-HER2 ADC. Pts received MCLA-128 (750 mg, 2h IV), trastuzumab (8 mg/kg loading, then 6 mg/kg) and vinorelbine (25 mg/m², D1 and 8), q3w. A safety run-in of MCLA-128 + trastuzumab ± chemotherapy was performed. Disease control rate (DCR; RECIST 1.1, per investigator), best overall response (BOR), overall response rate (ORR), safety, and PK are evaluated. Data cutoff was 14Nov2019. Results: 28 pts with a median 3 lines (range 2-5) of anti-HER2 therapy (metastatic setting) and 3 (range 1-6) metastatic sites, received a median of 5 (range 1-17) MCLA-128 cycles. Among 26 pts evaluable for efficacy, 20 patients had CR/PR/SD as BOR; DCR was 77% (90%CI: 60-89) with 1 confirmed CR and 4 PRs (2 unconfirmed). Common related AEs (all grades; G3-4) were neutropenia/neutrophil count decrease (61%; 46%), diarrhea (61%; 4%), asthenia/fatigue (46%; 0), nausea (29%; 0). No clinically significant LVEF decline was seen. At the end of cycle 1, mean trough levels of MCLA-128 was 19.1 µg/mL, and mean terminal half-life was 112 h (n = 8-11). Data on the primary endpoint, clinical benefit rate at 24 weeks, and biomarkers will be provided. Conclusions: The triplet MCLA-128-based combination is active in heavily pretreated pts with HER2+/amplified MBC. The regimen is safe and well tolerated with a manageable AE profile mostly related to the chemotherapy component. Clinical trial information: NCT03321981 .

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Kekre, H. B., Tanuja Sarode i Shachi Natu. "Performance Comparison of Wavelets Generated from Four Different Orthogonal Transforms for Watermarking With Various Attacks". INTERNATIONAL JOURNAL OF COMPUTERS & TECHNOLOGY 9, nr 3 (15.07.2013): 1139–52. http://dx.doi.org/10.24297/ijct.v9i3.3340.

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This paper proposes a watermarking technique using different orthogonal wavelet transforms like Hartley wavelet, Kekrewavelet, Slant wavelet and Real Fourier wavelet transform generated from corresponding orthogonal transform. Theseorthogonal wavelet transforms have been generated using different sizes of component orthogonal transform matrices.For example 256*256 size orthogonal wavelet transform can be generated using 128*128 and 2*2 size componentorthogonal transform. It can also be generated using 64*64 and 4*4, 32*32 and 8*8, 16*16 and 16*16 size componentorthogonal transform matrices. In this paper the focus is to compare the performance of above mentioned transformsgenerated using 128*128 and 2*2 size component orthogonal transform and 64*64 and 4*4 size component orthogonaltransform in digital image watermarking. The other two combinations are not considered as their performance iscomparatively not as good. Comparison shows that wavelet transforms generated using (128,2) combination of orthogonalÂ transform give better performances than wavelet transforms generated using (64,4) combination of orthogonaltransformfor contrast stretching, cropping, Gaussian noise, histogram equalization and resizing attacks. Real Fourierwavelet and Slant wavelet prove to be better for histogram equalization and resizing attack respectively than DCT waveletand Walsh wavelet based watermarking presented in previous work.

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LIÑÁN-CEMBRANO, G., S. ESPEJO, R. DOMÍNGUEZ-CASTRO i A. RODRÍGUEZ-VÁZQUEZ. "AN IMPROVED ELEMENTARY PROCESSING UNIT FOR HIGH-DENSITY CNN-BASED MIXED-SIGNAL MICROPROCESSORS FOR VISION". Journal of Circuits, Systems and Computers 12, nr 06 (grudzień 2003): 675–90. http://dx.doi.org/10.1142/s0218126603001100.

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This paper presents the architecture of the Elementary Processing Unit — EPU — which has been employed to design a CNN-Based 128×128 Focal Plane Mixed-Signal Microprocessor for vision. The EPU contains the required building blocks to implement, on chip, vision algorithms based on the execution of linear 3×3 convolution masks,1 or information propagative CNN templates.2 Using this EPU, we have designed a prototype, called ACE16k, which contains an array of 128×128 EPUs and a completely digital interface, in a standard fully-digital 0.35 μm CMOS technology. The estimation results forecast 300 GOPS, 3.23 GOPS/mm2 and 100 GOP/J.

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Pistilli, Barbara, Hans Wildiers, Erika Paige Hamilton, Ana Alexandra Ferreira, Florence Dalenc, Maria Vidal, Joaquín Gavilá i in. "Clinical activity of MCLA-128 (zenocutuzumab) in combination with endocrine therapy (ET) in ER+/HER2-low, non-amplified metastatic breast cancer (MBC) patients (pts) with ET-resistant disease who had progressed on a CDK4/6 inhibitor (CDK4/6i)." Journal of Clinical Oncology 38, nr 15_suppl (20.05.2020): 1037. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.1037.

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1037 Background: MCLA-128 (zenocutuzumab) is an ADCC-enhanced humanized bispecific antibody targeting HER2 and HER3 and potently blocking HER3-ligand induced receptor dimerization. Upregulation of Her2:Her 3 pathway is a means of resistance to ET in HR+ breast cancer, indicating a potential role for MCLA-128. In preclinical studies, the combination of MCLA-128 with ET in breast cancer xenografts outperformed single drug treatments. The current study explores the use of MCLA-128 to rescue pts with ET-resistant MBC who have progressed on a CDK4/6i. Methods: This phase II, open-label trial planned for up to 40 evaluable women with HR+, HER2 low (IHC 1+/IHC 2+ with negative FISH) MBC, who had progressed on a CDK4/6i and up to 3 lines of ET, who had received ≤ 2 chemotherapy regimens in the metastatic setting. Pts received MCLA-128 (750 mg, 2h IV, flat dose) q3w combined with last ET on which the pt had previously progressed immediately prior to study entry. Disease control rate (DCR; RECIST 1.1, per investigator), best overall response (BOR), overall response rate (ORR), safety, and PK, are evaluated. Data cut off was 14Nov2019. Results: 48 pts were treated, all of whom had progressed on a CDK4/6i. Pts had received a median 2 prior ET lines (range 1-5) and 1 line (range 1-3) of chemotherapy. Pts had a median number of 3 metastatic sites (range 1-6) and 42 (88%) had visceral involvement. Among 42 pts evaluable for efficacy, DCR was 45% (90% CI 32-59) with 2 pts having unconfirmed PR and 19 pts SD as BOR. Common related AEs (all grades; G3-4) were asthenia/fatigue (27%; 2%), diarrhea (25%; 0), nausea (21%; 0). No clinically significant LVEF decline was seen. At the end of cycle 1, mean trough level of MCLA-128 was 15.5 µg/mL, and mean terminal half-live was 102 h (n = 19-21). Data on the primary endpoint, clinical benefit rate at 24 weeks, and biomarkers will be provided. Conclusions: The addition of MCLA-128 to the last line of ET showed clinical activity after ET+CDK4/6i failure and a favorable safety profile. Clinical trial information: NCT03321981 .

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Dong, Shucan, Shengwei Jiang, Biwei Hou, Yaokun Li, Baoli Sun, Yongqing Guo, Ming Deng, Dewu Liu i Guangbin Liu. "miR-128-3p Regulates Follicular Granulosa Cell Proliferation and Apoptosis by Targeting the Growth Hormone Secretagogue Receptor". International Journal of Molecular Sciences 25, nr 5 (27.02.2024): 2720. http://dx.doi.org/10.3390/ijms25052720.

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The proliferation and apoptosis of granulosa cells (GCs) affect follicle development and reproductive disorders, with microRNAs playing a crucial regulatory role. Previous studies have shown the differential expression of miR-128-3p at different stages of goat follicle development, which suggests its potential regulatory role in follicle development. In this study, through the Cell Counting Kit-8 assay, the EDU assay, flow cytometry, quantitative real-time polymerase chain reaction, Western blot, and the dual-luciferase reporter assay, we used immortal human ovarian granulosa tumor cell line (KGN) cells as materials to investigate the effects of miR-128-3p and its predicted target gene growth hormone secretagogue receptor (GHSR) on GC proliferation and apoptosis. The results show that overexpression of miR-128-3p inhibited the proliferation of KGN cells, promoted cell apoptosis, and suppressed the expression of proliferating cell nuclear antigen (PCNA) and B-cell lymphoma-2 (BCL2) while promoting that of Bcl-2 associated X protein (BAX). The dual-luciferase reporter assay revealed that miR-128-3p bound to the 3′ untranslated region sequence of GHSR, which resulted in the inhibited expression of GHSR protein. Investigation of the effects of GHSR on GC proliferation and apoptosis revealed that GHSR overexpression promoted the expression of PCNA and BCL2, enhanced GC proliferation, and inhibited cell apoptosis, whereas the opposite effects were observed when GHSR expression was inhibited. In addition, miR-128-3p and GHSR can influence the expression of extracellular signal-regulated kinase 1/2 protein. In conclusion, miR-128-3p inhibits KGN cell proliferation and promotes cell apoptosis by downregulating the expression of the GHSR gene.

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Papadaki, Chara, Alexia Monastirioti, Konstantinos Rounis, Dimitrios Makrakis, Konstantinos Kalbakis, Christoforos Nikolaou, Dimitrios Mavroudis i Sofia Agelaki. "Circulating MicroRNAs Regulating DNA Damage Response and Responsiveness to Cisplatin in the Prognosis of Patients with Non-Small Cell Lung Cancer Treated with First-Line Platinum Chemotherapy". Cancers 12, nr 5 (19.05.2020): 1282. http://dx.doi.org/10.3390/cancers12051282.

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The expression of microRNA (miR)-21, miR-128, miR-155, and miR-181a involved in DNA damage response (DDR) and tumor responsiveness to platinum was assessed by RT-qPCR in the plasma of patients with non-small cell lung cancer (NSCLC; n = 128) obtained prior to initiation of first-line platinum chemotherapy. U6 small nuclear RNA (snRNA) was used for normalization, and fold change of each miRNA expression relative to the expression in healthy controls was calculated by the 2−ΔΔCt method. MicroRNA expression levels were correlated with patients’ outcomes. Integrated function and pathway enrichment analysis was performed to identify putative target genes. MiR-128, miR-155, and miR-181a expressions were higher in patients compared to healthy donors. MiRNA expression was not associated with response to treatment. High miR-128 and miR-155 were correlated with shorter overall survival (OS), whereas performance status (PS) 2 and high miR-128 independently predicted for decreased OS. In the squamous (SqCC) subgroup (n = 41), besides miR-128 and miR-155, high miR-21 and miR-181a expressions were also associated with worse survival and high miR-155 independently predicted for shorter OS. No associations of miRNA expression with clinical outcomes were observed in patients with non-SqCC (n = 87). Integrated function and pathway analysis on miRNA targets revealed significant enrichments in hypoxia-related pathways. Our study shows for the first time that plasma miR-128 and miR-155 hold independent prognostic implications in NSCLC patients treated with platinum-based chemotherapy possibly related to their involvement in tumor response to hypoxia. Further studies are needed to investigate the potential functional role of these miRNAs in an effort to exploit their therapeutic potential.

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Shen, Cangliang, Yaguang Luo, Xiangwu Nou, Gary Bauchan, Bin Zhou, Qin Wang i Patricia Millner. "Enhanced Inactivation of Salmonella and Pseudomonas Biofilms on Stainless Steel by Use of T-128, a Fresh-Produce Washing Aid, in Chlorinated Wash Solutions". Applied and Environmental Microbiology 78, nr 19 (29.06.2012): 6789–98. http://dx.doi.org/10.1128/aem.01094-12.

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ABSTRACTThe effect of the washing aid T-128 (generally recognized as safe [GRAS] formulation, composed mainly of phosphoric acid and propylene glycol) on inactivation ofSalmonellaandPseudomonaspopulations in biofilms on stainless steel was evaluated under conditions of increasing organic matter loads in chlorinated wash solutions dominated by hypochlorous acid. Biofilms were formed statically on stainless steel coupons suspended in 2% lettuce extract after inoculation withSalmonella entericaserovar Thompson or Newport or withPseudomonas fluorescens. Coupons with biofilms were washed in chlorine solutions (0, 0.5, 1, 2, 5, 10, or 20 mg/liter at pH 6.5, 5.0 and 2.9), with or without T-128, and with increasing loads of organic matter (0, 0.25, 0.5, 0.75, or 1.0% lettuce extract). Cell populations on coupons were dispersed using intermittent, pulsed ultrasonication and vortexing and enumerated by colony counts on XLT-4 orPseudomonasagars. Cell responses to fluorescent viability staining of biofilm treatment washing solutions were examined using confocal laser scanning microscopy. Results showed that 0.1% T-128 (without chlorine) reducedP. fluorescensbiofilm populations by 2.5 log10units but did not reduceSalmonellapopulations. For bothSalmonellaandPseudomonas, the sanitizing effect of free chlorine (1.0 to 5.0 mg/liter) was enhanced (P< 0.05) when it was combined with T-128. Application of T-128 decreased the free chlorine depletion rate caused by increasing organic matter in wash waters and significantly (P< 0.05) augmented inactivation of bacteria in biofilms compared to treatments without T-128. Image analysis of surfaces stained with SYTO and propidium iodide corroborate the cultural assay results showing that T-128 can aid in reducing pathogen viability in biofilms and thus can aid in sanitizing stainless steel contact surfaces during processing of fresh-cut produce.

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Jiang, Yunfeng, Yue Wang, Yu Sun i Hong Jiang. "Long non-coding RNA Peg13 attenuates the sevoflurane toxicity against neural stem cells by sponging microRNA-128-3p to preserve Sox13 expression". PLOS ONE 15, nr 12 (9.12.2020): e0243644. http://dx.doi.org/10.1371/journal.pone.0243644.

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Background Exposure to anesthetics during brain development may impair neurological function, however, the mechanisms underlying anesthetic neurotoxicity are unclear. Recent studies indicate that long non-coding RNAs (lncRNAs) are crucial for regulating the functional brain development during neurogenesis. This study aimed to determine the regulatory effects and potential mechanisms of lncRNA Peg13 (Peg13) on sevoflurane exposure-related neurotoxicity against neural stem cells (NSCs). Methods Mouse embryotic NSCs were isolated and their self-renewal and differentiation were characterized by immunofluorescence. NSCs were exposed to 4.1% sevoflurane 2 h daily for three consecutive days. The potential toxicities of sevoflurane against NSCs were evaluated by neurosphere formation, 5-ethynyl-2'-deoxyuridine (EdU) incorporation and flow cytometry assays. The Peg13, miR-128-3p and Sox13 expression in NSCs were quantified. The potential interactions among Peg13, miR-128-3p and Sox13 were analyzed by luciferase reporter assay. The effects of Peg13 and/or miR-128-3p over-expression on the sevoflurane-related neurotoxicity and Sox13 expression were determined in NSCs. Results The isolated mouse embryotic NSCs displayed potent self-renewal ability and differentiated into neurons, astrocytes and oligodendrocytes in vitro, which were significantly inhibited by sevoflurane exposure. Sevoflurane exposure significantly down-regulated Peg13 and Sox13, but enhanced miR-128-3p expression in NSCs. Transfection with miR-128-3p mimics, but not the control, significantly mitigated the Peg13 or Sox13-regulated luciferase expression in 293T cells. Peg13 over-expression significantly reduced the sevoflurane-related neurotoxicity and increased Sox13 expression in NSCs, which were mitigated by miR-128-3p transfection. Conclusion Such data indicated that Peg13 mitigated the sevoflurane-related neurotoxicity by sponging miR-128-3p to preserve Sox13 expression in NSCs.

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Liu, Shinan, Shuai Gao, Zhaoyu Yang i Peng Zhang. "miR-128-3p reduced acute lung injury induced by sepsis via targeting PEL12". Open Medicine 16, nr 1 (1.01.2021): 1109–20. http://dx.doi.org/10.1515/med-2021-0258.

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Abstract Objective Acute lung injury (ALI) caused by sepsis is clinically a syndrome, which is featured by damage to the alveolar epithelium and endothelium. In this study, we employed mice models of cecal ligation and puncture (CLP) and primary mice pulmonary microvascular endothelial cells (MPVECs) in vitro to investigate the effect of miR-128-3p in ALI caused by sepsis. Methods miR-128-3p agomir or randomized control were injected into adult male C57BL/6 mice 1 week before the CLP surgery. We used miR-128-3p agomir or scrambled control to transfect MPVECs and then employed lipopolysaccharide (LPS) stimulation on the cells. Pellino homolog 2 (PELI2) was predicted to be a direct target of miR-128-3p via luciferase reporter assay. MPVECs were cotransfected with lentiviral vector that expressed PELI2 (or empty vector) as well as miR-128-3p-mimics 1 day before LPS stimulation in rescue experiment. Transcriptional activity of caspase-3, cell apoptosis rate, and the expression levels of miR-128-3p, interleukin-1β (IL-1β), interleukin-6 (IL-6), and PELI2 were analyzed. Results Compared with the sham group, the lung of mice in the CLP group showed pulmonary morphological abnormalities, and the expression of IL-6 and IL-1β, caspase-3 activity, and apoptosis rate were significantly upregulated in the CLP group. Inflammatory factor levels and apoptosis rate were also significantly induced by LPS stimulation on MPVECs. Upregulation of miR-128-3p effectively inhibited sepsis-induced ALI, apoptosis as well as inflammation. miR-128-3p also played a role in antiapoptosis and anti-inflammation in MPVECs with LPS treatment. PEL12 upregulation in MPVECs alleviated miR-128-3p-induced caspase-3 activity inhibition and pro-inflammatory factor production. Conclusions miR-128-3p enabled to alleviate sepsis-induced ALI by inhibiting PEL12 expression, indicating a novel treatment strategy of miR-128-3p for sepsis-induced ALI.

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Wei, Wei, Yang Jie Zhou, Ju Lian Shen, Lu Lu, Xin Ru Lv, Tao Tao Lu, Pei Tao Xu i Xie Hua Xue. "The Compatibility of Alisma and Atractylodes Affects the Biological Behaviours of VSMCs by Inhibiting the miR-128-5p/p21 Gene". Evidence-Based Complementary and Alternative Medicine 2022 (7.07.2022): 1–13. http://dx.doi.org/10.1155/2022/7617258.

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Objective. The compatibility of Alisma and Atractylodes (AA) has been estimated to exhibit antiatherosclerotic effects, but the mechanism remains unclear. This study aimed to identify the role of AA in oxidized low-density lipoprotein (ox-LDL)-induced vascular smooth muscle cell (VSMC) behaviours and to explore the effects of microRNAs (miRNAs). Methods. A scratch wound-healing assay was used to detect the migration of VSMCs, and immunocytochemistry and western blotting for SM22ɑ were used to evaluate phenotypic transformation. Bromodeoxyuridine (BrdU) immunocytochemistry and flow cytometry were applied to detect the proliferation of VSMCs. miRNA microarray profiling was performed using Lianchuan biological small RNA sequencing analysis. VSMCs were transfected with the miR-128-5p mimic and inhibitor, and the migration, phenotypic modulation, and proliferation of VSMCs were investigated. The 3′UTR-binding sequence site of miR-128-5p on the p21 gene was predicted and assessed by luciferase assays. Result. AA and the extracellular regulated protein kinase 1/2 (ERK1/2) blocker U0126 markedly inhibited migration, elevated smooth muscle 22α (SM22α) expression, repressed VSMC proliferation, elevated miR-466f-3p and miR-425-3p expression, and suppressed miR-27a-5p and miR-128-5p expression in ox-LDL-induced VSMCs. miR-128-5p targets the tissue inhibitor of metalloproteinases (TIMPs), silent information regulator 2 (SIRT2), peroxisome proliferator-activated receptor (PPAR), and p21 genes, which are linked to the behaviours of VSMCs. The miR-128-5p mimic promoted the migration and proliferation of VSMCs and suppressed p21, p27, and SM22ɑ expression. The inhibitor increased p21, p27, and SM22ɑ expression and repressed the migration, phenotypic transformation, and proliferation of VSMCs. miR-128-5p directly targeted the 3′UTR-binding sequences of the p21 gene, negatively regulated p21 expression, and supported the proliferation of VSMCs. Conclusion. Our research showed that the migration, phenotypic transformation, and proliferation of ox-LDL-induced VSMCs were repressed by AA through inhibiting miR-128-5p by targeting the p21 gene, which may provide an effective option for the treatment of atherosclerosis.

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Yang, Peng, Jianhua Han, Shigeng Li, Shaoning Luo, Xusheng Tu i Zhiqiang Ye. "miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2". Open Medicine 16, nr 1 (1.01.2021): 274–83. http://dx.doi.org/10.1515/med-2021-0222.

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Abstract Background Sepsis is a systemic inflammatory response that can lead to the dysfunction of many organs. The aberrant expression of miRNAs is associated with the pathogenesis of sepsis. However, the biological functions of miR-128-3p in sepsis remain largely unknown, and its mechanism should be further investigated. This study aimed to determine the regulatory network of miR-128-3p and TGFBR2 in lipopolysaccharide (LPS)-induced sepsis. Methods The expression levels of miR-128-3p and transforming growth factor beta receptors II (TGFBR2) were detected by quantitative polymerase chain reaction (qPCR). The protein levels of TGFBR2, Bcl-2, Bax, cleaved caspase 3, Smad2, and Smad3 were measured by western blot. Cell apoptosis was analyzed by flow cytometry. Cytokine production was detected by enzyme-linked immunosorbent assay (ELISA). The binding sites of miR-128-3p and TGFBR2 were predicted by Targetscan online software and confirmed by dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay. Results The level of miR-128-3p was decreased, and TGFBR2 expression was increased in serum samples of sepsis patients and LPS-induced HK2 cells. Overexpression of miR-128-3p or knockdown of TGFBR2 ameliorated LPS-induced inflammation and apoptosis. Moreover, TGFBR2 was a direct target of miR-128-3p, and its overexpression reversed the inhibitory effects of miR-128-3p overexpression on inflammation and apoptosis in LPS-induced HK2 cells. Besides, overexpression of miR-128-3p downregulated TGFBR2 to suppress the activation of the Smad signaling pathway. Conclusion miR-128-3p could inhibit apoptosis and inflammation by targeting TGFBR2 in LPS-induced HK2 cells, which might provide therapeutic strategy for the treatment of sepsis.

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An, Chunyan, Wei Bai i Donglei Zhang. "Meet-in-the-middle differential fault analysis on Midori". Electronic Research Archive 31, nr 11 (2023): 6820–32. http://dx.doi.org/10.3934/era.2023344.

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<abstract>Midori is a lightweight block cipher designed by Banik et al. and presented at the ASIACRYPT 2015 conference. According to the block size, it consists of two algorithms, denoted as Midori-64 and Midori-128. Midori generates 8-bit S-Boxes from 4-bit S-Boxes and applies almost MDS matrices instead of MDS matrices. In this paper, we introduce the meet-in-the-middle fault attack model in the 4-round cell-oriented fault propagation trail and reduce the key space in the last round by $ 2^{45.71} $ and $ 2^{39.86} $ for Midori-64 and Midori-128, respectively. For Midori-64, we reduce the time complexity from $ 2^{80} $ to $ 2^{28} $, $ 2^{32} $ and $ 2^{56} $ for the different single fault injection approaches. For Midori-128, we provide a 4-round fault attack method, which slightly increases the complexity compared to previous attacks. Our results indicate that the first and last four rounds of Midori must be protected to achieve its security.</abstract>

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Vilibic-Cavlek, Tatjana, Vladimir Stevanovic, Snjezana Kovac, Ema Borko, Maja Bogdanic, Gorana Miletic, Zeljka Hruskar i in. "Neutralizing Activity of SARS-CoV-2 Antibodies in Patients with COVID-19 and Vaccinated Individuals". Antibodies 12, nr 4 (25.09.2023): 61. http://dx.doi.org/10.3390/antib12040061.

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Background: Serological diagnosis of COVID-19 is complex due to the emergence of different SARS-CoV-2 variants. Methods: 164 serum samples from (I) patients who recovered from COVID-19 (n = 62) as well as (II) vaccinated individuals (n = 52) and (III) vaccinated individuals who were infected with different SARS-CoV-2 variants after vaccination (n = 50) were included. All samples were tested using EIA (binding antibodies) and a virus neutralization test (VNT) using the Wuhan strain (NT antibodies). Group III was further tested with a VNT using the Alpha/Delta/Omicron strains. Results: The highest antibody index (AI) was observed in vaccinated individuals infected with COVID-19 (median AI = 50, IQR = 27–71) and the lowest in vaccinated individuals (median AI = 19, IQR = 8–48). Similarly, NT antibody titer was highest in vaccinated individuals infected with COVID-19 (median 128; IQR = 32–256) compared to vaccinated individuals (median 32, IQR = 4–128) and patients with COVID-19 (median 32, IQR = 8–64). The correlation between AI and NT titer was strongly positive in vaccinated individuals and moderately positive in patients with COVID-19. No significant correlation was observed in vaccinated individuals infected with COVID-19. In patients infected with Alpha and Delta, the lowest VNT positivity rate was for the Omicron variant (85.0%/83.3%). Patients infected with the Alpha variant showed the lowest NT titer for the Omicron variant (median titer 32) compared to the Wuhan/Delta variants (64/128). Patients infected with the Delta variant had the lowest NT titer to the Omicron variant (median 32), compared to the Wuhan/Alpha variants (64/128). Patients infected with the Omicron variant showed similar titers to the Delta/Wuhan variants (128) and higher to the Alpha variant (256). Conclusions: The cross-immunity to SARS-CoV-2 is lowest for the Omicron variant compared to the Alpha/Delta variants.

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Zhuang, H., S. S. Chuang i H. K. Das. "Transcriptional regulation of the apolipoprotein B100 gene: purification and characterization of trans-acting factor BRF-2". Molecular and Cellular Biology 12, nr 7 (lipiec 1992): 3183–91. http://dx.doi.org/10.1128/mcb.12.7.3183-3191.1992.

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Apolipoprotein B100 (apoB), the only protein of low-density lipoprotein, is produced primarily in the liver and serves as a ligand for the low-density lipoprotein receptor. Hepatic cell-specific expression of the human apoB gene is controlled by at least two cis-acting positive elements located between positions-128 and -70 (H. K. Das, T. Leff, and J.L. Breslow, J. Biol. Chem. 263:11452-11458, 1988). The distal element (-128 to -85) appears to be liver specific since it shows positive activity in HepG2 cells and negative activity in HeLa cells. The proximal element (-84 to -70) acts as a positive element in both these cell lines, and two rat liver nuclear proteins, BRF-1 and C/EBP, bind to two overlapping sites (-84 to -60 and -70 to -50, respectively). By gel mobility shift assay, we have identified a rat liver nuclear protein (BRF-2) which binds to the distal element (-128 to -85) of the apoB gene. This putative trans-acting factor has been purified to apparent homogeneity by DEAE-cellulose, heparin-agarose, and DNA-specific affinity chromatography. The purified BRF-2 has an apparent molecular mass of 120 kDa and was found to specifically recognize sequence -128 to -85; BRF-2 also produced a strong hypersensitive site at nucleotide position -95 with copper-orthophenanthroline reagent. A double-stranded oligonucleotide (-128 to -85) containing a 3-nucleotide (TTC) insertion between position -95 and -94 was found to abolish DNA binding by BRF-2. This result suggests that the region surrounding the hypersensitive site -95 is important for protein-DNA interaction. By using apoB promoter fragments containing various internal deletions as templates for gel mobility shift assay, the region between -104 and -85 was identified to be crucial for binding by BRF-2. We propose that BRF-2 may play an important role in the tissue-specific regulation of apoB gene transcription.

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Zhuang, H., S. S. Chuang i H. K. Das. "Transcriptional regulation of the apolipoprotein B100 gene: purification and characterization of trans-acting factor BRF-2." Molecular and Cellular Biology 12, nr 7 (lipiec 1992): 3183–91. http://dx.doi.org/10.1128/mcb.12.7.3183.

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Apolipoprotein B100 (apoB), the only protein of low-density lipoprotein, is produced primarily in the liver and serves as a ligand for the low-density lipoprotein receptor. Hepatic cell-specific expression of the human apoB gene is controlled by at least two cis-acting positive elements located between positions-128 and -70 (H. K. Das, T. Leff, and J.L. Breslow, J. Biol. Chem. 263:11452-11458, 1988). The distal element (-128 to -85) appears to be liver specific since it shows positive activity in HepG2 cells and negative activity in HeLa cells. The proximal element (-84 to -70) acts as a positive element in both these cell lines, and two rat liver nuclear proteins, BRF-1 and C/EBP, bind to two overlapping sites (-84 to -60 and -70 to -50, respectively). By gel mobility shift assay, we have identified a rat liver nuclear protein (BRF-2) which binds to the distal element (-128 to -85) of the apoB gene. This putative trans-acting factor has been purified to apparent homogeneity by DEAE-cellulose, heparin-agarose, and DNA-specific affinity chromatography. The purified BRF-2 has an apparent molecular mass of 120 kDa and was found to specifically recognize sequence -128 to -85; BRF-2 also produced a strong hypersensitive site at nucleotide position -95 with copper-orthophenanthroline reagent. A double-stranded oligonucleotide (-128 to -85) containing a 3-nucleotide (TTC) insertion between position -95 and -94 was found to abolish DNA binding by BRF-2. This result suggests that the region surrounding the hypersensitive site -95 is important for protein-DNA interaction. By using apoB promoter fragments containing various internal deletions as templates for gel mobility shift assay, the region between -104 and -85 was identified to be crucial for binding by BRF-2. We propose that BRF-2 may play an important role in the tissue-specific regulation of apoB gene transcription.

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38

Derkach, S. M., M. V. Miahka, V. V. Volkohon, L. T. Nakonechna, S. B. Dimova, N. O. Kravchenko i N. V. Lutsenko. "MORPHOLOGICAL AND CULTURAL, PHYSIOLOGICAL AND BIOCHEMICAL PECULIARITIES OF MICROMYCETES STRAINS INCLUDING IN THE COMPOSITION OF TRICHODERMA HARZIANUM 128 ASSOCIATION". Agriciltural microbiology 28 (10.07.2018): 17–26. http://dx.doi.org/10.35868/1997-3004.28.17-26.

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Objective. Screen the active cellulolytic strains of Trichoderma micromycetes, investigate their morphological and cultural, physiological and biochemical properties for further use in the composting of organic substrates as a straw destroyer. Methods. Microbiological, biochemical, statistical. Results. 150 isolates of cellulolytic microscopic fungi of the genus Trichoderma were obtained from semi-decomposed straw. Among isolated fungi, the most active influence on the destruction of cellulose is typical for the association of micromycetes Trichoderma sp. 128. The components of the association (Trichoderma sp. 128/1 and Trichoderma sp. 128/2, respectively) differ in their nature of growth in the digest medium, colouring of colonies, and cellulolytic activity. Under simultaneous cultivation of the association components in a medium where the only source of carbon is filter paper or straw, higher effect was observed compared with than their separate cultivation. The selected association provides a degree of straw decomposition of up to 33 % over a period of 21 days, which exceeds the activity of the known cellulolytic strain Trichoderma harzianum F-2455. By morphological and cultural, physiological and biochemical properties, the components of the fungal association have been identified as Trichoderma harzianum 128/1 and T. harzianum 128/2 (association – Trichoderma harzianum 128, respectively). Under the study of virulence of microorganisms on the model of white mice, it was established that the association components are not pathogenic for warm-blooded animals, which allows the association to be used in the production. Conclusion. Active cellulolytic association of micromycetes which includes two strains has been selected. The association is identified as Trichoderma harzianum 128. The use of the association of micromycetes can be promising when composting organic matter, in order to accelerate its mineralization.

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39

Guinea, Jesús, Sandra Recio, Pilar Escribano, Teresa Peláez, Beatriz Gama i Emilio Bouza. "In Vitro Antifungal Activities of Isavuconazole and Comparators against Rare Yeast Pathogens". Antimicrobial Agents and Chemotherapy 54, nr 9 (21.06.2010): 4012–15. http://dx.doi.org/10.1128/aac.00685-10.

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ABSTRACT We compared the in vitro activities of isavuconazole, posaconazole, voriconazole, and fluconazole against Dipodascus capitatus (n = 21), Saccharomyces cerevisiae (n = 20), Rhodotorula mucilaginosa (n = 18), and Trichosporon spp. (n = 15). The MIC50s, MIC90s, and MIC ranges (in μg/ml) obtained using the CLSI M27-A3 procedure were as follows: isavuconazole, 0.125, 0.5, and ≤0.015 to 2; posaconazole, 0.5, 2, and ≤0.015 to >16; voriconazole, 0.125, 2, and ≤0.015 to 8; and fluconazole, 4, >128, and ≤0.125 to >128. Isavuconazole showed potent activity against the isolates studied.

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40

Heylen, Line, Els Oris, Elke Wollants, Piet Maes, Margaretha Van Kerrebroeck, Jacques Peeters i Deborah Steensels. "128 days of SARS-CoV-2 viral shedding in a haemodialysis patient". Clinical Kidney Journal 14, nr 4 (24.01.2021): 1284–86. http://dx.doi.org/10.1093/ckj/sfab004.

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41

Bohigas, Joaqun, i Mauricio Tapia. "Sh 2-128: An Hiiand Star-forming Region in the Galactic Outback". Astronomical Journal 126, nr 4 (październik 2003): 1861–70. http://dx.doi.org/10.1086/378054.

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42

Berndt, Andre, Katja Stehfest i Peter Hegemann. "Mutations in Cys 128 cause extreme decelerations of the Channelrhodopsin-2 kinetics". Biophysical Journal 96, nr 3 (luty 2009): 671a. http://dx.doi.org/10.1016/j.bpj.2008.12.3547.

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43

Slott, Sofie, Cecilie Schiøth Krüger-Jensen, Izabela Ferreira da Silva, Nadia Bom Pedersen i Kira Astakhova. "Mutations in microRNA-128-2-3p identified with amplification-free hybridization assay". PLOS ONE 18, nr 8 (22.08.2023): e0289556. http://dx.doi.org/10.1371/journal.pone.0289556.

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We describe a quantitative detection method for mutated microRNA in human plasma samples. Specific oligonucleotides designed from a Peyrard-Bishop model allowed accurate prediction of target:probe recognition affinity and specificity. Our amplification-free tandem bead-based hybridization assay had limit of detection of 2.2 pM. Thereby, the assay allowed identification of single-nucleotide polymorphism mismatch profiles in clinically relevant microRNA-128-2-3p, showing terminal mutations that correlate positively with inflammatory colitis and colorectal cancer.

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44

Guan, Steven, Ko-Tsung Hsu i Parag V. Chitnis. "Fourier Neural Operator Network for Fast Photoacoustic Wave Simulations". Algorithms 16, nr 2 (19.02.2023): 124. http://dx.doi.org/10.3390/a16020124.

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Simulation tools for photoacoustic wave propagation have played a key role in advancing photoacoustic imaging by providing quantitative and qualitative insights into parameters affecting image quality. Classical methods for numerically solving the photoacoustic wave equation rely on a fine discretization of space and can become computationally expensive for large computational grids. In this work, we applied Fourier Neural Operator (FNO) networks as a fast data-driven deep learning method for solving the 2D photoacoustic wave equation in a homogeneous medium. Comparisons between the FNO network and pseudo-spectral time domain approach were made for the forward and adjoint simulations. Results demonstrate that the FNO network generated comparable simulations with small errors and was orders of magnitude faster than the pseudo-spectral time domain methods (~26× faster on a 64 × 64 computational grid and ~15× faster on a 128 × 128 computational grid). Moreover, the FNO network was generalizable to the unseen out-of-domain test set with a root-mean-square error of 9.5 × 10−3 in Shepp–Logan, 1.5 × 10−2 in synthetic vasculature, 1.1 × 10−2 in tumor and 1.9 × 10−2 in Mason-M phantoms on a 64 × 64 computational grid and a root mean squared of 6.9 ± 5.5 × 10−3 in the AWA2 dataset on a 128 × 128 computational grid.

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45

Doerr, C. R., L. W. Stulz, M. Cappuzzo, L. Gomez, A. Paunsecu, E. Laskowski, S. Chandrasekhar i L. Buhl. "2 x 2 wavelength- selective cross connect capable of switching 128 channels in sets of eight". IEEE Photonics Technology Letters 14, nr 3 (marzec 2002): 387–89. http://dx.doi.org/10.1109/68.986822.

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Alsina, Maria, Valentina Boni, Jan H. M. Schellens, Victor Moreno, Kees Bol, Martine Westendorp, L. Andres Sirulnik, Josep Tabernero i Emiliano Calvo. "First-in-human phase 1/2 study of MCLA-128, a full length IgG1 bispecific antibody targeting HER2 and HER3: Final phase 1 data and preliminary activity in HER2+ metastatic breast cancer (MBC)." Journal of Clinical Oncology 35, nr 15_suppl (20.05.2017): 2522. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.2522.

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2522 Background: MCLA-128 is a novel IgG1 bispecific antibody with enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity targeting HER2 and HER3 receptors. We report final phase 1 single agent escalation data, and safety and preliminary activity at the recommended phase 2 dose (RP2D). Methods: In the phase 1 part, patients (pts) with advanced solid tumors received MCLA-128 every 3 weeks (q3w) IV over 1-2 hr from 40 to 900 mg. In the phase 2 part, pts with selected metastatic indications were treated at the RP2D. Antitumor activity was assessed as per RECIST 1.1. Clinical benefit rate (CBR) was defined as CR + PR + SD ≥12 weeks. Results: As of January 2017, 28 advanced solid tumor pts were treated in the escalation part. No dose limiting toxicities were seen. The RP2D was established as 750 mg q3w (flat dose, corticosteroid premedication) based on safety and PK data. Fifteen pts with HER2 amplified tumors were treated at the RP2D (8 MBC, 4 gastric, 2 ovarian, 1 colorectal). Median age was 52 years (range 33-71), ECOG PS 0/1: 3/12, all ≥2 metastatic sites. The safety profile at the RP2D confirmed dose escalation data; the most common AEs were infusion related reactions in 6 pts (40%; G1-2 in 5 pts, G4 in 1 pt), and G1-2 diarrhea, rash, fatigue in 2 pts each (13%). No congestive heart failure or significant LVEF decreases occurred. The 8 MBC pts had a median 5.5 prior lines of metastatic therapy (range 4-14), all had progressed on 3 prior Her2 inhibitor therapies and received a median of 4.5 MCLA-128 cycles (range 2-12); 1 had a confirmed PR, 5 had SD (including 2 sustained, 11 and 12 cycles). SD was also seen in 2 evaluable MBC pts treated at 480 mg in the phase 1 part (7 and 4 cycles). Overall, CBR in these 10 MBC pts was 70%. Evaluation of other indications is ongoing. Conclusions: MCLA-128 showed a well tolerated safety profile. Consistent antitumor activity was seen in heavily pretreated MBC patients progressing on HER2 therapies. Further exploration of MCLA-128 based combinations with chemotherapy or trastuzumab in less pretreated MBC patients progressing after ≥2 prior Her2 inhibitors including TDM-1 is planned. Clinical trial information: NCT02912949.

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Chowdhury, Saleha Begum. "Dr. Shabnom Ferdous Chowdhury". Bangladesh Journal of Obstetrics & Gynaecology 29, nr 2 (27.11.2016): 128. http://dx.doi.org/10.3329/bjog.v29i2.30497.

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Hoque, Kazi Zahidul, Masumul Gani Chowdhury, Abu Sayeed Munsi, Rezoana Rima i Manzoor Hussain. "Surgical Placement of Permanent Pacemaker Following Temporary Trasvenous Pacemaker in a Child with Congenital Heart Block and Moderate Size PDA: A Case Report". Bangladesh Journal of Child Health 40, nr 2 (13.02.2017): 124–28. http://dx.doi.org/10.3329/bjch.v40i2.31569.

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Dong, Guochen, Xuanxue Mo, Zhidan Zhao, Liang Wang i Su Zhao. "Linzizong Volcanic Rocks in Linzhou of Tibet: A Volcanic Petrologic Assemblage in Continental Collision Environment". Himalayan Journal of Sciences 2, nr 4 (29.01.2008): 128. http://dx.doi.org/10.3126/hjs.v2i4.830.

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Ishak, Muhammad Nuaim, Irfan Mohamad i Nik Fariza Husna Nik Hassan. "Dysphagia Even for Barium Swallow, What’s Next?" Journal of Medicine 21, nr 2 (9.11.2020): 127–28. http://dx.doi.org/10.3329/jom.v21i2.50221.

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