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1
Walsh, Karen. "Fragmentation and the European patent system : a substantive law perspective". Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:935909ac-0873-42ff-b21f-cb63334c4c6f.
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Over fifty years after its original inception, the idea for a European unitary patent system has not yet been realised. Each attempt to introduce such a system has been met with fierce criticism. For the most recent proposal, the so-called unitary patent package, this tradition has continued. One of the most significant issues at the core of a majority of criticisms is that the existing European patent system is fragmented and that the proposed system will further increase this fragmentation. The almost universal assumption of commentators has been that this is a shortcoming of the system. However, to date no proper consideration of the legitimacy of this assumption has been attempted. Commentators have not asked what might the consequences be for the European patent system if fragmentation is a significant feature of the proposed system. This thesis considers the legitimacy of the assumption regarding the dangers of fragmentation for the European patent system, including substantive patent law. The conclusion reached has been that while fragmentation is a central feature of the existing European patent system, and is moreover likely to be a central feature of the proposed European unitary patent system, this is cause for neither criticism nor concern. On the contrary, fragmentation is not only an inherent feature of any European patent system, but also a desirable one. It is an inherent feature because no system has replaced the last, and rather than unifying the area, indirect law making has ensured a level of fragmentation. It is a desirable feature because the goals of European harmonisation and integration are not pursued entirely at the expense of national diversity. The fragmentation that exists within the current and future European patent systems should not be perceived as a negative feature of those systems, but rather embraced as an inherent and positive feature of them.
2
Alazard-Fontbonne, Joëlle. "La commande artistique et littéraire de Charles le Chauve". Paris 10, 2007. http://www.theses.fr/2007PA100185.
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La commande artistique et littéraire de Charles le Chauve est la commande princière la plus importante de l’époque carolingienne. Les œuvres reçues par le roi témoignent tant de sa grande piété que de sa volonté de gouverner selon l’idéal du roi « philosophe » , le souverain cherchant à se gouverner lui-même pour mieux gouverner son peuple et le mener au salut. Les œuvres témoignent en outre des ambitions politiques de Charles qui souhaite accéder à l’Empire. Proclamant la continuité avec l’Empire romain, l’iconographie et les thèmes développés par les sources littéraires et figurées sont extrêmement inspirés de l’époque paléochrétienne. Ceux-ci s’inscrivent par ailleurs dans le sillon des œuvres commandées par Charlemagne, empruntant aussi plus ponctuellement aux œuvres de l’Empire byzantin. Le croisement des sources textuelles et des images permet de mesurer l’influence de Jean Scot et d’Hincmar de Reims sur la production artistique du royaume ; il permet aussi de mieux comprendre l’élaboration de l’image royale (dont les codes se mettent alors en place) et l’utilisation que Charles fit des œuvres pour renforcer son pouvoir, donnant de lui l’image du souverain chrétien idéalThe literary and artistic patronage of Charles the Bald is by far the richest of the carolingian age. The king received works that were either commissioned, or inspired by him. They actually reflect not only his piety, but also his ambition to rule as an enlightened king and to become an Emperor. The works contain the carolingian ideal of continuity with Roman Empire : iconography and themes of the literary sources and the pictures are extremely inspired by the paleochristian age. The artistic and literary patronage reveals the influence of works commisionned by Charlemagne and byzantine emperors too. The study of both texts and images bring to light the influence of John Scotus and Hincmar of Reims on the artistic production of the realm. It allows as well a better understanding of the making of the royal image (whose codes are defined in this period) and the use of the works by Charles the Bald to strengthhen his power, giving of himself the image of an ideal christian king
3
Brousseau, Nicholas. "Recherches sur la diplomatique de Louis le Germanique (817-876) : étude comparatiste". Paris 1, 2005. http://www.theses.fr/2005PA010591.
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Cette thèse est consacrée à l'étude des diplômes royaux de Louis le Germanique (t 876), roi en Francie orientale (833-876). Il s'agissait avant tout d'explorer les linéaments d'une évolution fondamentale pour l'histoire européenne: l'individualisation de la Francie orientale. Mais poser cette question supposait de s'appuyer sur une documentation dont deux des traits principaux ont guidé la démarche de cette thèse: le rôle éminent de l'écrit dans l'expression du pouvoir royal au IXe siècle, tout d'abord, et donc l'attention accordée par ses acteurs aux formes et aux conséquences de l'instrumentation des décisions; la longue chaîne ensuite qui relie ces traces écrites du pouvoir aux historiens qui les examinent aujourd'hui. Les diplômes ont ainsi été étudiés sous trois angles différents: historique, diplomatique et historiographique. Lorsque cela s'avérait pertinent, ils ont été comparés avec les actes des autres rois carolingiens, particulièrement ceux de Charles le Chauve (840-877). Pour comprendre l'évolution de la documentation diplomatique du IXe siècle, il fallut d'abord retracer celle des conditions de production des actes (partie I). Il importa ensuite de retourner à la source, c'est-à-dire d'examiner attentivement les diplômes royaux (partie II). Enfin, une analyse des éditions critiques des actes, publiées aux XIXe-XXe siècles et qui sont les intermédiaires privilégiés entre la source et 1 'historien, vint compléter ce travail (partie III). Notre étude permet de conclure à une évolution distincte des diplômes royaux qui est le reflet d'un projet politique cohérent: la création d'un royaume de Francie orientale par Louis le Germanique
4
Flanagan, Claire Susan. "Observations of glitches in PSR 0833-45 and 1641-45". Thesis, Rhodes University, 1996. http://hdl.handle.net/10962/d1005266.
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An eleven-year series of radio timing observations of 0833- 45 (Vela) and PSR 1641- 45 is presented. During this time, five large spin-ups ("glitches") were observed in 0833- 45 and one in 1641-45. The stellar response to these events is investigated, and the three relat ively long complete inter-glitch intervals in 0833-45 are modeled. The results are of relevance to studies of the interiors of neutron stars. The initial aim of the project - to obtain good observational coverage of large glitches in the Vela pulsar - was successfully achieved, and high quality observations of the periods between glitches were obtained as a by-product. The results of the analysis presented here provide support for the existence of both linear and non-linear coupling in the Vela pulsar, and put a limit on the former in PSR 1641- 45. The recently observed existence of a rapidly recovering component of part of a glitch in Vela was verified in the subsequent glitch, although there is now evidence to contradict the suggestion that this component involves a particular region of the star that is implicated in every glitch. Observations of a recent glitch in the same pulsar have resolved a small component of the spin-up; such a component has not been reported for any other large glitch.
5
Pellerin, Anne. "Coexistence de populations stellaires dand la galaxie IRAS 0833+652". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0015/MQ47228.pdf.
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Kyle, I. Francis. "God's co-worker nineteenth-century "uncommon Christian" James Brainerd Taylor as a model for twenty-first-century evangelism /". Portland, OR : Western Seminary, 2009. http://dx.doi.org/10.2986/tren.002-0843.
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Affum, John Badu. "Images of God examining and expanding formatee's images of God, images that challenge but also fit our particular milieu, a Ghanaian perspective /". Chicago, IL : Catholic Theological Union at Chicago, 2008. http://dx.doi.org/10.2986/tren.033-0853.
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Ashiegbu, Paul Okoro. "Church unity in John 17". Chicago, IL : Catholic Theological Union at Chicago, 2008. http://dx.doi.org/10.2986/tren.033-0843.
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McCrery, Susan. "That all may be one reconfiguration as a contemporary expression of the charism of the Congregation of St. Joseph /". Chicago, IL : Catholic Theological Union at Chicago, 2008. http://dx.doi.org/10.2986/tren.033-0833.
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Obu-Anukam, Angela Ngozi. "The power of the silenced women, agency and conscientization in the Igbo church /". Chicago, IL : Catholic Theological Union at Chicago, 2007. http://dx.doi.org/10.2986/tren.033-0863.
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Schramm, Mark J. "Supervision across cultures directions for ministry supervision during the SVD crosscultural training program /". Chicago, IL : Catholic Theological Union at Chicago, 2008. http://dx.doi.org/10.2986/tren.033-0837.
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Johnson, Carolyn S. "Developing servant leaders in rural Isaan churches through apprenticeship". Theological Research Exchange Network (TREN), 2007. http://www.tren.com/search.cfm?p002-0813.
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Willoughby, Jason. "Pastoring in an addictive age changing how we do ministry when everybody's sick /". Theological Research Exchange Network (TREN), 2008. http://www.tren.com/search.cfm?p002-0833.
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Pritzlaff, Allen. "Evangelizing Russian-speaking Muslims in Kazakhstan through contextualizing the Scriptures a case study /". Theological Research Exchange Network (TREN), 2007. http://www.tren.com/search.cfm?p002-0823.
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Page, William D. "Ministering to the shepherd a guide for when terminal illness strikes the pastor's family /". Theological Research Exchange Network (TREN), 2007. http://www.tren.com/search.cfm?p002-0837.
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Reutterer, Thomas, Kurt Hornik, Nicolas March i Kathrin Gruber. "A data mining framework for targeted category promotions". Springer, 2016. http://dx.doi.org/10.1007/s11573-016-0823-7.
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This research presents a new approach to derive recommendations for
segment-specific, targeted marketing campaigns on the product category level. The
proposed methodological framework serves as a decision support tool for customer
relationship managers or direct marketers to select attractive product categories for
their target marketing efforts, such as segment-specific rewards in loyalty programs,
cross-merchandising activities, targeted direct mailings, customized supplements in
catalogues, or customized promotions. The proposed methodology requires cus-
tomers' multi-category purchase histories as input data and proceeds in a stepwise
manner. It combines various data compression techniques and integrates an opti-
mization approach which suggests candidate product categories for segment-specific
targeted marketing such that cross-category spillover effects for non-promoted
categories are maximized. To demonstrate the empirical performance of our pro-
posed procedure, we examine the transactions from a real-world loyalty program of
a major grocery retailer. A simple scenario-based analysis using promotion
responsiveness reported in previous empirical studies and prior experience by
domain experts suggests that targeted promotions might boost profitability between
15 % and 128 % relative to an undifferentiated standard campaign.
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Rogers, Phil. "Next steps Christian spirituality and discipleship for the next generation /". Theological Research Exchange Network (TREN), 2007. http://www.tren.com/search.cfm?p033-0823.
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Cox, Gary Ransom. "Embracing biblical baptism a review of the salient issues so that elders may effectively defend the doctrine of covenant baptism /". Charlotte, NC : Reformed Theological Seminary, 2007. http://dx.doi.org/10.2986/tren.083-0044.
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Frost, Donald Charles. "Global partnership mission the re-emerging role of the local church in world mission in the 21st century /". Charlotte, NC : Reformed Theological Seminary, 2008. http://dx.doi.org/10.2986/tren.083-0060.
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Manring, Noah D. "The element of dance in worship". Charlotte, NC : Reformed Theological Seminary, Virtual Campus, 2006. http://dx.doi.org/10.2986/tren.083-0038.
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Turley, Stephen R. "Paul, the law, and the dawning of the messianic age an eschatological proposal for the law faith contrast in Galatians 2: 15-21 /". Theological Research Exchange Network (TREN), access this title online, 2006. http://dx.doi.org/10.2986/tren.083-0031.
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Stubbs, Joseph Olan. "Biblical masculinity understanding biblical masculinity /". Theological Research Exchange Network (TREN), access this title online, 2006. http://dx.doi.org/10.2986/tren.083-0032.
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Hansen, Silva Erwin Guillermo. "Nonlinear conditional risk-neutral density estimation in discrete time with applications to option pricing, risk preference measurement and portfolio choice". Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/nonlinear-conditional-riskneutral-density-estimation-in-discrete-time-with-applications-to-option-pricing-risk-preference-measurement-and-portfolio-choice(0369c1bb-0873-42c8-a0cf-d18356b3643e).html.
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In this thesis, we study the estimation of the nonlinear conditionalrisk-neutral density function (RND) in discrete time. Specifically, weevaluate the extent to which the estimated nonlinear conditional RNDvaluable insights to answer relevant economic questions regarding to optionpricing, the measurement of invertors' preferences and portfolio choice.We make use of large dataset of options contracts written on the S&P 500index from 1996 to 2011, to estimate the parameters of the conditional RNDfunctions by minimizing the squared option pricing errors delivered by thenonlinear models studied in the thesis.In the first essay, we show that a semi-nonparametric option pricing modelwith GARCH variance outperforms several benchmarks models in-sample andout-of-sample. In the second essay, we show that a simple two-state regimeswitching model in volatility is not able to fully account for the pricingkernel and the risk aversion puzzle; however, it provides a reasonablecharacterisation of the time-series properties of the estimated riskaversion.In the third essay, we evaluate linear stochastic discount factormodels using an out-of-sample financial metric. We find that multifactormodels outperform the CAPM when this metric is used, and that modelsproducing the best fit in-sample are also those exhibiting the bestperformance out-of-sample.
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Ramsahai, Roland Ryan. "Causal inference with instruments and other supplementary variables". Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:df2961da-0843-421f-8be4-66a92e6b0d13.
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Instrumental variables have been used for a long time in the econometrics literature for the identification of the causal effect of one random variable, B, on another, C, in the presence of unobserved confounders. In the classical continuous linear model, the causal effect can be point identified by studying the regression of C on A and B on A, where A is the instrument. An instrument is an instance of a supplementary variable which is not of interest in itself but aids identification of causal effects. The method of instrumental variables is extended here to generalised linear models, for which only bounds on the causal effect can be computed. For the discrete instrumental variable model, bounds have been derived in the literature for the causal effect of B on C in terms of the joint distribution of (A,B,C). Using an approach based on convex polytopes, bounds are computed here in terms of the pairwise (A,B) and (A,C) distributions, in direct analogy to the classic use but without the linearity assumption. The bounding technique is also adapted to instrumental models with stronger and weaker assumptions. The computation produces constraints which can be used to invalidate the model. In the literature, constraints of this type are usually tested by checking whether the relative frequencies satisfy them. This is unsatisfactory from a statistical point of view as it ignores the sampling uncertainty of the data. Given the constraints for a model, a proper likelihood analysis is conducted to develop a significance test for the validity of the instrumental model and a bootstrap algorithm for computing confidence intervals for the causal effect. Applications are presented to illustrate the methods and the advantage of a rigorous statistical approach. The use of covariates and intermediate variables for improving the efficiency of causal estimators is also discussed.
25
Lim, Diane S. W. "Organosilicon reagents in carbon-carbon bond forming reactions : towards the total synthesis of incednine". Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:beb3e9cb-087d-4c96-97f4-da611d08f9f9.
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This thesis investigates a total synthesis of the incednine aglycon by utilising alkenylsilane reagents to assemble the pentaenyl and tetraenyl systems through cross-coupling reactions. The early chapters develop methodology to access both cyclic alkenylsiloxanes and functionalised (E)-alkenylsilanes by the controlled hydrogenation of alkynylsiloxanes and silylolefination of aldehydes, respectively, and culminate in the synthesis of a C6-C13 bis(alkenylsilane)incednine fragment (Scheme 1). The C1-C5 and C14-C23 coupling partners are synthesised in three and ten steps from propargyl alcohol and L-alanine methyl ester through phosphorous-based olefination strategies. In the final chapter we describe our first generation approach to incednine which entails orthogonal cross-couplings to construct the C5-C6 and C13-C14 bonds (Scheme 2).
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Flores, Díaz Marietta. "A UDP-glucose deficient mutant cell line as a model to study the cytotoxicity of Clostridium perfringens PLC /". Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-7349-087-3/.
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Flöter, Rådestad Angelique. "Testosterone treatment in women : aspects on sexuality, well-being and metabolism /". Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-083-4/.
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Paletschek, Sylvia. "Die permanente Erfindung einer Tradition : die Universität Tübingen im Kaiserreich und in der Weimarer Republik /". Stuttgart : Steiner, 2001. http://hsozkult.geschichte.hu-berlin.de/rezensionen/NG-2002-083.
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Permpoonpattana, Patima. "Clostridium difficile : infection and immunity". Thesis, Royal Holloway, University of London, 2013. http://repository.royalholloway.ac.uk/items/33009ec4-7815-0803-d39b-f968c8d9cdbb/7/.
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Clostridium difficile is a Gram positive pathogen of significant importance in the UK, Europe and the USA. No vaccine has been developed and current treatments are focused on hospital management and the use of antibiotics. The disease is spread in hospitals in the spore form and the role of spores in C. difficile infecton is poorly understood. In this project spores of C. difficile have been characterised. The proteins from the outermost layers of the spore were identified and the genes cloned. Three of these surface proteins have unique enzymatic properties that maybe important for symptoms of disease. The ability of C. difficile spores to adhere to intestinal cells was found to be far greater than with live cells and through this we have identified that the spore may play an important role in colonisation. The regulation of spore coat gene expression during sporulation was also examined and temporal phases of genes expression identified. A major part of this project was to develop a mucosal vaccine to C. difficile. The approach used was to clone the C-terminus of toxin A onto the surface of Bacillus subtilis spores and use these recombinant spores to immunise mice and hamsters. We found that oral delivery of these spores conferred 75% protection to C. difficile infection in a hamster model of infection. Further, parenteral immunisation of the same antigens (toxin A and B) failed to generate mucosal responses and this showed that mucosal immunisation is critical for good protection. Finally, we found that antibodies to the C-terminus of toxin A were cross reactive to the C-terminus of toxin B. This showed that mucosal delivery of just the C-terminus of toxin A is sufficient to confer protection in an animal model of infection. The outcome of this work is that we have shown the parameters for successful immunisation and vaccination against C. difficile.
30
Said, Mahfouz Mohamed. "User-generated video as a new genre of documentary". Thesis, Royal Holloway, University of London, 2012. http://repository.royalholloway.ac.uk/items/b4ce3451-f22c-0875-20c3-820ffb7d3a87/8/.
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This study analyses the behavior of Internet users interested in producing their own documentary videos and assesses the characteristics and techniques that govern the production of such videos. The development and global diffusion of Internet 2.0 technologies have facilitated a rapid proliferation of user-generated video, of varying quality and aesthetic seriousness, on the Internet in recent years. These videos are produced by amateur Internet users, and express the dominant social, cultural, and political trends of their respective milieux while also reflecting the new availability of affordable mobile cameras and editing software. These new tools are helping thousands of ordinary people to explore their political and artistic concerns in an unprecedented, public way. User-generated video is increasingly considered a valid source of information by mainstream media networks, to the point that it is even coming to occupy a central role in some forms of news broadcasting. This study raises an essential question: Can we view user-generated amateur video as a new form of documentary? From this question there derive other important questions about the various forms that these new videos take, the ways that they are produced, the expertise of the people who make them, the distinctive characteristics, if any, of their content, and the extent to which their makers comply with the ethical standards of professional documentary-making. The theoretical part of this study explains the concept of the professional documentary, its formal characteristics, modes, and ethical requirements, as well as highlighting the differences between documentary, news and reality TV. A working definition of user-generated video will then be proposed in light of developments in media studies and new media theory. The practical part of the study centres on an e-workshop for non-professional documentary-makers in Egypt called egdoc. The workshop is set up in such a way as to allow the behavior of amateur users of the site to be analysed and ultimately compared with the behavior of professional documentary-makers. The launching of the egdoc website coincided with the aftermath of the revolution which began in Egypt on 25 January 2011. This dramatic context, and the unprecedented quantity of amateur video documenting revolutionary events, generated a healthy level of interest in the egdoc project and soon gave rise to an adequate sample of amateur video. The egdoc study also serves, in its own right, as a valuable snapshot of Egyptian public opinion in the historic period that it covers. The most important lesson gleaned from the egdoc experience was that the distinction between professional and user-generated amateur documentary is fast becoming blurred. Some of the users of egdoc can hardly be described as amateurs when you compare their final product with a professional production in terms of either content or form. In addition, the egdoc experience suggests that political and social circumstances may contribute to the development of new forms of non-professional documentary in the future.
31
Ma, Hongrui. "Optical diagnostics and combustion analysis in a gasoline direct injection engine". Thesis, University of Oxford, 2006. http://ora.ox.ac.uk/objects/uuid:46364c15-08d3-4984-af3b-819ef0bdc847.
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Gasoline Direct Injection (GDI) engines work with stratified charge at part load and burn with lean mixtures in order to save fuel, whilst at full load, the fuel and air mix homogeneously for maximum power output. The higher compression ratio and the absence of throttling are two of the most significant benefits of GDI engines. The key issues facing GDI combustion include in-cylinder mixture preparation and post-combustion soot formation. This work was intended to investigate these aspects and was undertaken on a dedicated Jaguar single-cylinder optical GDI engine with a spray-guided combustion system. The spray-guided concept does not rely as much on charge motion or piston design, and can avoid wall-wetting effects so as to reduce engine emissions. Relevant engine control hardware and data acquisition equipment were commissioned. Data/image processing software was also developed to suit the measurements. A data-processing case study with data from a small two-stroke glow ignition engine has been conducted to develop a method to combine the burn rate and heat release analyses in the study of engines with premixed charge but compression ignition. Difficulties such as unknown ignition timing and polytropic index have been addressed. Results for all operating conditions have shown good correlations between the two methods. The technique of quantitative planar laser-induced fluorescence is useful for measuring 2-D fuel distribution in GDI engines. The relevant physics and literature were reviewed in depth. A multi-component fuel was designed to give reasonable co-evaporation characteristics with tracers matching different fuel fractions. The absorption and fluorescence features of each fuel component and tracer were characterised. Optimisation of hardware and signal-to-noise ratio was performed. A recirculating loop was set up for the calibration of the technique. The technique of colour-ratio pyrometry (CRP) for estimating the temperature and loading of soot was applied on the GDI engine. Critical features of the candidate CCD colour camera including its spectral response and noise behaviours were fully studied. Validation tests with reference sources together with an error analysis suggested an accuracy of ±50K within the combustion temperature range. Engine combustion images were then taken under various operating conditions. Temperature estimates were shown to be insensitive to the concentration of soot. Simulation with a thermodynamic modelling package, ISIS, was introduced for comparison with the experimental data. With careful tuning, ISIS gave outputs comparable to the CRP and proved to be a cost-effective tool to study GDI engines. High-speed combustion imaging was carried out using a CMOS camera, allowing the study of flame properties as well as crank-angle resolved CRP. By using a lens in the piston crown to give full bore optical access and appropriate image processing, the flame front could be detected reliably throughout the main combustion process.
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Khan, Faisal Farooq. "Design, implementation and experimental validation of a network-based model to predict mitotic microtubule regulating proteins". Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:7c27b09b-08c3-43f5-93c3-0580cf5fd103.
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The purpose of this thesis was to study mitosis in Drosophila, from a network biology perspective. The primary aim was to develop and test a network-based prediction model that could integrate available data in public databases (like Flybase) and, based on that, predict potential mitotic proteins. The approach taken to design the protein interaction network included the use of a priori knowledge about the microtubule composition of the mitotic spindle and the higher likelihood of microtubule-associated proteins (MAPs) to have a putative mitotic function. The design also included the integration of different complementary datasets, from gene expression and functional RNAi screens to cross species conservation of MAPs for fitting a network-based model for predicting mitotic proteins. I begin with the creation of the MAP interactome based on a MAP dataset in Drosophila. This initial network was extended by transferring homologs and interologues of MAP datasets from four other species, i.e. human, mouse, rat and Arabidopsis. These proteins were then used as seed proteins to conduct a virtual pull-down experiment, by adding indirect interactors into the network, i.e. proteins that directly bind to two or more MAPs within the network, which completed the MAP interactome. Data from genome-wide studies in Drosophila were gathered for each node in the MAP interactome. These ‘layers’ of data were then used as features to fit a prediction model that could score each node in the network, based on the likelihood of its role in mitosis. The final model performed with 96% accuracy after 10-fold cross validation and was used to rank all the proteins in the MAP interactome. By analysing the top 100 high scoring predicted mitotic proteins, a highly connected cluster of 33 proteins was identified that was subject to experimental validation in the lab. The first approach was to conduct an in vitro analysis using an RNAi screen to test for any spindle, chromosome or centrosome phenotypes upon gene knockdown. After two independent RNAi screens, around 80% of the proteins produced mutant mitotic phenotypes strongly supporting the results of the MAP prediction model. The second approach was to conduct an in vivo analysis by expressing GFP- fusion constructs of selected genes from the subcluster. These were expressed in Drosophila early embryos to study their subcellular localization during interphase and mitosis. A variety of localizations were observed ranging from chromatin and microtubules to more generic cytoplasmic localizations. These results suggested not all predicted proteins were co-localizing with microtubules, and therefore might not necessarily be microtubule associated proteins but can possibly be functioning as microtubule associated regulator proteins. Proteomics analysis of a subset of these genes showed a large proportion of false positive interactions but also picked new interactions between member proteins that highlighted a module within the subcluster. The RNAi hits from the in vitro analysis and the members of the module within subcluster-16 from the in vivo analysis provide interesting subjects for further characterization.
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Ball, Catherine Jane. "Palladium- and copper-catalysed heterocycle synthesis". Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:589b70fb-0823-4ccf-8b35-1883908f917d.
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A number of privileged starting materials based on aryl halide frameworks have emerged that allow access to a variety of different heterocyclic scaffolds through judicious choice of reaction conditions. This work describes efforts to develop and extend the utility of two of these general heterocycle precursors - ortho-(haloalkenyl)aryl halides A and α-(ortho-haloaryl) ketones B - in conjunction with cascade reactions involving the construction of key carbon-heteroatom bonds via palladium or copper catalysis. Chapter 1 entails an overview of the development of palladium- and copper-catalysed carbon-heteroatom bond forming processes. The application of these processes in heterocycle synthesis using ortho-(haloalkenyl)aryl halide and ortho-haloacetanilides/ α-(ortho-haloaryl) ketone precursors is also described. Chapter 2 focuses on the development of a two-step synthesis of cinnolines using ortho-(haloalkenyl)aryl halides via intermediate protected dihydrocinnoline derivatives C. Chapter 3 demonstrates how the inherent reactivity of protected dihydrocinnoline derivatives C can be harnessed to provide access to functionalised products. A brief target synthesis of a pharmaceutically-relevent cinnoline is also described. Chapter 4 details attempts to develop a novel synthesis of benzothiophenes D from both ortho-(haloalkenyl)aryl halide and α-(ortho-haloaryl) ketone precursors.
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Poblete, Pacheco Paulina Isabel. "The need for, and the use of, three dimensional simulation in dental education". Thesis, University of Dundee, 2017. https://discovery.dundee.ac.uk/en/studentTheses/a45d8c20-0874-44f5-a5a1-dee7a927b477.
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Despite the growing number of publications relating to three-dimension (3D) and education, the need for this technology, its usability and educational impact are not clear for dental education with the exception of haptics. The first stage of this doctoral research used a mixed method to examine key stakeholders’ views about those areas of dentistry that would benefit from having a 3D learning resource. Two hundred and five dental students, academics and graduates responded to the survey (134 females and 71 males). Results suggested that several areas of dentistry would benefit from 3D animations or simulations. Anatomy of the Temporomandibular joint (TMJ) was the top priority area from the list of the identified items. After identifying the areas of need, the researcher determined principles for e-learning and instructional design; followed by a feasibility study that identified a suitable authoring tool for the construction of a resource capable of containing 3D interactive models. A multidisciplinary team headed by the researcher developed the first iBook addressing the Tooth Morphology of the permanent dentition. The researcher collected feedback from users of the tooth morphology iBook using a mixed method experimental study, which included a questionnaire and a focus group session. Scottish and Chilean participants (n=138), from the University of Dundee and The Andes respectively, indicated that the iBook was well designed and it was a valuable resource where they could interact with the 3D models provided. These results informed the construction of a second iBook addressing the anatomy of the temporomandibular joint (TMJ) and masticatory system. Two versions of the TMJ iBook were created: a 3D version containing interactive models and a 2D version holding images. The researcher designed a comparative study including a pre-test/post-test intervention and a questionnaire to compare results from the two groups (3D and 2D). Twenty-seven first-year and thirty-two third-year dental students from the University of Dundee participated. The results of the intervention revealed statistically significant improvements in the results of first-years students who used the 3D version iBook compared to those who used the 2D one. The third-year cohort results revealed no significant difference between the 2D and 3D groups. The researcher arranged two focus group sessions to gain a deeper insight into the results. From those who took part in the intervention, eleven volunteered for the focus group sessions (six first years and five third-years). Results indicated that the TMJ iBook was a valuable resource for learning. Regardless the year of study, all participants preferred the use of the 3D interactive models as they had the potential to simplify visualisation and orientation, and enhance motivation for learning. Three key findings arose from this doctoral study. The first one indicates that several areas of dentistry would benefit from 3D resources and they would satisfy dental students’ needs. The second conclusion suggests that iBooks are a powerful, straightforward and valuable resource for creating new e-learning interactive material capable of displaying 3D models. The final finding suggests that the use of 3D interactive models have the potential to enhance learning in novice dental students, while they are capable of motivating and aiding visualisation both in junior and experienced students.
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James, Carl. "Optimising strategies to enhance endurance running performance under hot and humid conditions". Thesis, University of Brighton, 2016. https://research.brighton.ac.uk/en/studentTheses/e587e092-0878-4d44-8666-3469fedf27c8.
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The purpose of this thesis was to optimise preparation for endurance runners competing in a hot environment. A multidisciplinary approach was adopted, investigating acute and chronic interventions to identify the most effective preparation. The determinants of endurance performance model (Bassett & Howley 2000) facilitated simultaneous investigation of the efficacy of interventions as well as the physiological mechanisms through which interventions influence performance. Finally, a retrospective analysis was conducted to identify the relationship between physiological markers and endurance running in the heat, in order to inform training prioritisation. Study 1 investigated the validity and reliability of skin temperature (TSKIN) measurement tools at rest and during treadmill running, to identify an appropriate measurement tool for use in subsequent studies, without restrictive trailing wires. A thermal camera provided insufficient levels of validity and reliability for safe monitoring of TSKIN, while telemetry thermistors provided a viable and more convenient alternative to the criterion measure of hard-wired thermistors. Study 2 investigated the effect of evidenced and practical internal (eg. ice slurry ingestion) and external precooling (eg. ice packs, forearm immersion and cold garments) strategies during incremental running in the heat. No differences were observed across the determinants of endurance performance between cooling techniques, with both eliciting modest reductions in blood lactate accumulation, compared with no cooling, which may prevent a decrement in the lactate turnpoint speed under heat stress. However, external cooling elicited a greater reduction in TSKIN and thermal sensation, alleviating perceived thermal strain further than internal cooling. Study 3 investigated ischaemic preconditioning (IP), which may enhance endurance performance through haemodynamic and/or metabolic mechanisms, prior to incremental running in the heat. IP had no effect on the determinants of endurance performance. The thermoregulatory responses to exercise-induced hyperthermia may supersede previously reported effects of IP, which is not recommended as an ergogen prior to exercise in the heat. Study 4 investigated the effect of a chronic strategy, involving five days of controlled hyperthermia heat acclimation (HA), on the determinants of endurance performance and a 5 km time trial in the heat. Heat acclimation improved V̇O2max, the lactate thresholds and 5 km performance. Alleviated physiological, thermal and metabolic strain were observed, likely attributable to enhanced cardiovascular stability and heat dissipation. Five days of controlled hyperthermia HA appears to be a potent strategy to support endurance running in the heat. Study 5 directly compared acute (external precooling), chronic (HA) and combined (precooling & HA) strategies during 5 km running. Precooling did not improve performance following HA, despite modest alleviation of physiological strain, which may indicate an inappropriate pacing strategy. Heat acclimation improved performance further than precooling (HA +6.6%, precooling +3.7%), indicating HA should be prioritised, although precooling appears beneficial when acclimation is not possible. Multiple, linear regression indicated the physiological determinants of endurance performance do not accurately predict endurance performance in the heat (R2=0.72, standard error of the estimate =105.6 s). The unexplained variation during endurance performance in the heat may reflect a greater prominence of perceptual measures to influence running in the III heat. Preparation for competition in the heat should therefore prioritise improving perceived thermal and exertional strain under heat stress, alongside improving traditional physiological markers.
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gaudens, gérald. "Espaces profinis et problèmes de réalisabilité de structures algébriques comme cohomologie d'un espace topologique". Phd thesis, Université de Nantes, 2002. http://tel.archives-ouvertes.fr/tel-00002406.
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\medskip\noindent{\it Résumé.~} En utilisant une méthode due à L. Schwartz, nous établissons une conjecture due à N. Kuhn qui affirme que l'action de l'algèbre de Steenrod sur la cohomologie d'un espace topologique à coefficients dans le corps premier $\mathbb{F} _2$ est soit localement finie, soit non polynômiale. Pour cela, nous construisons une suite spectrale d'Eilenberg-Moore dans le cadre de la théorie homotopique des espaces profinis de F. Morel (cette partie du travail est une collaboration avec F.-X. Dehon). \smallskip\noindent Nous démontrons pour cette suite spectrale, qui converge toujours au sens naïf, un théorème de convergence forte, dans l'esprit de celui de W. G. Dwyer. Nos preuves sont simplifiées par la propreté du calcul homotopique des espaces profinis, que nous établissons. \smallskip\noindent Nous montrons également qu'une algèbre instable connexe dont l'idéal d'augmentation n'est pas localement nilpotent admet une série de Loewy infinie 'aux nilpotents près'. \smallskip\noindent Enfin, nous donnons quelques exemples de modules instables non réalisables en utilisant des méthodes élémentaires.
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Fotoohi, Alan Kambiz. "Pharmacological and molecular investigations on the mechanisms underlying resistance of human leukaemia cells to the antimetabolites methotrexate, 6-mercaptopurine and 6-thioguanine /". Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-087-9/.
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Holm, Lena. "Epidemiological aspects on pain in whiplash-associated disorders /". Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-083-1/.
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Steele, Catherine A. "Measuring career anchors and investigating the role of career anchor congruence". Thesis, Coventry University, 2009. http://curve.coventry.ac.uk/open/items/4d808ce0-304f-08e3-36e3-c12a4460c409/1.
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This thesis empirically examines the career orientations inventory (COI) as a measure of career anchors and then, using this measure, it goes on to investigate the relationship between career anchor congruence and work related outcomes, specifically job satisfaction and organisational commitment. The psychometric properties of the 40 item COI (presented by Igbaria and Baroudi, 1993) were explored by the administration of the measure to a sample of 658 individuals from 27 organisations in the UK. Through factor analysis an eight factor structure was demonstrated in line with that proposed by Schein (1993). The factor structure was replicated with a second sample. The COI demonstrated good levels of internal consistency (.59-.83) and test retest reliability (.68-.90). Similarly it was deemed to have acceptable levels of face validity and construct validity when compared to Mantech’s (1983) Work Values Questionnaire (WVQ). An analysis of the prevalence of career anchors and the demographic differences within the current sample was undertaken. This analysis provided evidence to suggest that certain career anchors may be increasing in prevalence while others are decreasing. These findings are in line with current research on the way in which workplace changes are impacting upon careers (Baruch, 2004). Evidence was found that indicated gender differences in scores on the COI subscales. Specifically women were found to score higher on the lifestyle anchor and men to score higher on the general management anchor. Differences were also found between the age groups considered in this study in the general management, creativity, pure challenge and lifestyle anchors. Interaction effects for age and gender were found for the general management and sense of service anchors. The COI was then used to develop a commensurate measure of job career anchors. This job career anchor measure discriminated between jobs within one police organisation. The measure was then used to explore the relationship between career anchors, career anchor congruence (congruence between individual and job career anchors), job satisfaction and organisational commitment. Evidence was found to suggest that career anchors and career anchor congruence have a direct effect on job satisfaction (predicting 10% and 4% of the variance respectively). The analysis also showed support for the role of career anchor congruence as a moderator to the relationship between career anchors and job satisfaction. This thesis makes full consideration of the academic contributions and practical implications of the research presented whilst also considering its limitations. A number of suggestions for the direction of future research have been made.
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Hassine, Khaled. "Contribution à l'élaboration d'une approche de décomposition des traitements itératifs sur des architectures MIMD : application aux traitements de séquences d'images sur réseau de transputers". Valenciennes, 1994. https://ged.uphf.fr/nuxeo/site/esupversions/6059845e-087a-474f-94a6-09cb96fbf246.
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L’objectif de cette thèse consiste à étudier les modèles de parallélisation pour répondre aux besoins en puissance de calcul de deux outils de mesure de la direction du regard et d'analyse gestuelle. Le support, étant des séquences d'images, a introduit des contraintes temporelles sévères. Une étude algorithmique des traitements de séquences d'images et de nos applications a permis de dégager leur adaptation au parallélisme. La conception parallèle est par la suite abordée. Différentes techniques de parallélisation sont décrites. Le modèle Spmd (same program multiple data), le plus adapté à nos traitements, est détaillé. Ce modèle ne tient pas compte explicitement des surcharges inhérentes au parallélisme. Pour remédier à ces insuffisances, une approche de décomposition basée sur le modèle Spmd est proposée. L’approche présente une restructuration du parallélisme inhérent à une application en optimisant les différentes surcharges dues au parallélisme. Une transparence vis-à-vis de la machine cible est assurée. Les éventuelles contraintes temporelles liées aux applications sont prises en considération. L’approche est appliquée pour les traitements envisagés par les deux applications sur un réseau de transputers. Les résultats expérimentaux sont analysés en fonction des contraintes temporelles imposées. Des idées d'extensions sont proposées concernant le développement des applications et l'approche de parallélisation.
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Schiavon, Laurent. "Conditions de monotonie de la courbure pour les courbes et splines d'interpolation". Valenciennes, 2002. https://ged.uphf.fr/nuxeo/site/esupversions/ebd449f2-087e-4588-b4a1-bedcc9b86660.
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Pour une courbe, la courbure est une grandeur géométrique déterminante pour sa forme. Dans de nombreuses applications de la CAO (automobile, aéronautique), les courbes que l'on cherche à modéliser doivent être à courbure monotone, dans le but d'obtenir des formes aérodynamiques et esthétiques. Dans ce travail, nous apportons des solutions via les courbes polynomiales cubiques et rationnelles quadratiques (arcs coniques) quisont controlées par un ensemble de points (et de masses dans le cas rationnel)For a curve, the curvature is a deciding geometric feature for its shape. For some applications of CAD (automotive, aeronautics), it is important to maintain monotone curvature along the curve we aim to modelize in order to obtain aerodynamic and aesthetic shapes. In this work, solutions are given via the cubic polynomial curves and the quadratic rational curves (conic segments) which are controlled by a set of points (and weights in the rational case)
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Stehly, Ralph. "Le Ṣaḥīḥ de Bukhārî : texte avec versions parallèles, traduction et commentaire des hadiths 1 à 25 : contribution à l'étude du hadith". Bordeaux 3, 1995. http://www.theses.fr/1995BOR30019.
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Il s'agit d'une presentation critique des 25 premiers hadiths du sahih de bukhari. Pour chaque hadith sont indiques. 1) le texte arabe divise en versets 2) la synopse verset par verset des versions paralleles dans les six livres canoniques et dans le musnad d'ahmad b. Hanbal. 3) la traduction francaise annotee. Suivent plusieurs niveaux de commentaire. Le commentaire personnel se fonde sur la logique interne de bukhari et sur les elements qu l'on peut tirer de la comparaison des diverses versions, en dehors de la comprehension traditionnelle du texte par les exegetes musulmans de l'epoque classique. Cette derniere est fournie sous la forme d'un apercu des opinions de qastallani et de asqalani. Un eclairage d'histoire comparee des religions est donne pour le hadiths qui s'y pretentThis work is a critical presentation of the 25 first hadiths of al-bukhari's sahih. For each hadith we give. 1)the arabic text divided into verses 2) the verse by verse synopsis of the parallel versions found in the six canonical bokks and ahmad b. Hanbal's musnad. 3) the french translation with footnotes. Several levels of commentary follow. Our personnal commentaryis based on al0bulhari's internal logic which can be drawn from the comparison between the different versions and on the history of religions, outside the frame of the traditionnal understnading by classical muslim commentators. This understanding in given through the example of qastallani's and asqalani's commentaries
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Jugulytė, Kristina. "LR ambasadų komunikacinės veiklos formuojant šalies įvaizdį Europoje". Master's thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110217_161712-08753.
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Magistro darbe analizuojamas LR ambasadose formuojamas Lietuvos valstybės įvaizdis Europoje. Darbo objektas – komunikacinės ir viešųjų ryšių priemones, kuriomis diplomatai reprezentuoja valstybę, viešina ambasadoje vykstančius renginius ir bendrauja su užsienio tikslinėmis auditorijomis.
Tyrimas buvo atliekamas keliais etapais. Pirmiausia, apibrėžtas Lietuvos diplomatinių atstovybių vaidmuo formuojant valstybės įvaizdį, identifikuotos naudojamos viešųjų ryšių priemonės ir bendravimo su auditorijomis būdai. Kaip ambasados įgyvendina komunikacines veiklas, analizuota pasitelkiant anketinę apklausą bei interviu su skirtingose Europos valstybėse dirbančiais diplomatais. Galiausiai atlikti interviu su ekspertais padėjo įvertinti diplomatinių ir komunikacinių veiklų tikslingumą bei valstybės įvaizdžio formavimo galimybes viešosios diplomatijos kontekste.
Tyrimas atskleidė, jog skirtingose LR ambasadose yra naudojamos vienodos komunikacinės priemonės, kurių dažnumas priklauso nuo ambasadoje vykstančių renginių, dirbančių diplomatų skaičiaus bei turimo biudžeto. Tuo tarpu santykiai su žiniasklaida, kuri yra svarbus informacijos platinimo kanalas, atskirose valstybėse ne visada yra efektyvūs, nes ambasadų pateikiama informacija neretai laikoma propaganda bei lieka neaišku, ar žinutė pasiekė adresatą. Todėl daugiau dėmesio viešosios diplomatijos kontekste skiriama kultūriniams renginiams, kurie pristato ne tik šalį, bet ir atskirus jos kūrėjus, menininkus. Kultūrinė diplomatija... [toliau žr. visą tekstą]In this master paper the image of Lithuania in Europe, formed by the embassies of the Republic of Lithuania, is being analyzed. The object of the paper- communication and public relations measures, which are used by diplomats to represent the state, to publicize the events occurring in the embassy and to communicate with foreign target audiences. The research was done in several stages. At first the role of the Lithuanian diplomatic missions of forming the image of the state was determined, measures public relations and methods of communication with audiences were identified. The ways how the embassies establish communication activities were analyzed using questioning survey and interviews with the diplomats working in different European states. Finally the interviews with experts helped to evaluate the expediency of the diplomatic and communication activities and the state image formation possibilities in the context of public diplomacy. The research revealed that in different embassies of the Republic of Lithuania the same communication measures were being used and the frequency depends on the events in the embassy, number of diplomats working and budget. Meanwhile the relations wit mass media - which is important channel of information distribution – is not always effective in different states, because the information presented by embassies is often seen as propaganda and it is unclear if the message reaches the target. Therefore in the context of public diplomacy more... [to full text]
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Simonova, Jelena. "Kalba ir kalbėjimas Maurice'o Merleau-Ponty fenomenologinėje filosofijoje". Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110204_101857-08763.
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Kalba ir kalbėjimas Maurice’o Merleau-Ponty fenomenologinėje filosofijoje
Disertacijoje apmąstoma kalbos ir kalbėjimo dichotomija. Ferdinando de Saussure’o įvesta ir Merleau-Ponty interpretuota bei vaisingai išplėtota perskyra analizuojama todėl, kad individualus kalbėjimas, pasitelkus fenomenologinę perspektyvą, atsiskleidžia kaip gyvas ir intencionalus, – šiuo požiūriu jis įgyja pranašumų kalbos, kaip uždaros ženklų sistemos, atžvilgiu. Kalbėjimo reikšmės diakritiškumo problema darbe artikuliuojama, turint omenyje, kad juslinis suvokimas yra diakritinis. Dar daugiau, juslinis suvokimas pirmapradiškai yra išraiškingas ir visada koreliuoja su gyvenamo kūno ekspresyvumu, todėl Merleau-Ponty filosofijoje semantika yra įkūnyta semantika. Disertacijos autorei pritariant Merleau-Ponty įžvalgai, postuluojama, jog tapyba, literatūra bei filosofija taip pat yra kalbėjimo formos, kurių šaltinis inkrustuotas žmogaus kūniškume. Pratęsdamos gestą ir būdamos apspręstos prigimtinio žmogaus troškimo išreikšti ir pasakyti kažką vis naujai, jos išreiškia pirmapradį žmogaus patiriamą santykį su pasauliu bei liudija kalbinės žmogaus veiklos kreatyvumą.
Formuluojant šio tyrimo objektą, tikslinga išskirti ir paties Merleau-Ponty filosofavimo stilių bei ypatingą, analogo neturinčią kalbėjimo manierą. Ji išlaisvina bei pagrindžia kiekvieno žmogaus giliai asmeninio santykio su jo paties kalbėjimu galimybę ir atveria kelią naujai filosofavimo tendencijai, kuri numano žmogiškojo aš savęs bei jo... [toliau žr. visą tekstą]The thesis reflects on the dichotomy of language and speech. The separation, introduced by Ferdinand de Saussure and successfully interpreted and developed by Merleau-Ponty, is analyzed from a phenomenological perspective where the individual speech appears as live and intentional act; from this perspective, it gains advantages against the language as a system of signs. The problem of the diacricity of the meaning of speech is articulated keeping in mind that sensory perception is also diacritical. Moreover, sensory perception is expressive initially and always correlates to the expressivity of the lived body; therefore, the semantics of the philosophy of Merleau-Ponty represents embodied semantics. The author of the thesis agrees with the insight of Merleau-Ponty and his postulates that artistic painting, literature, and philosophy are forms of speaking whose resources are incrusted in the corporeity of human beings. Representing the extension of gestures and being determined by natural willingness of human beings to say and express something new, such forms of expression disclose the initial relationship of human beings with the world and witness the creativity of the linguistic activities of human beings. Defining the object of the research, it is reasonable to set the philosophical style and unmatched manner of speaking of Merleau-Ponty. It deliberates and substantiates the possibility of individual relationship of every human being with his/her speaking, and opens the... [to full text]
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Mentz, Søren. "The English gentleman merchant at work Madras and the City of London 1660-1740 /". Kbh. : Museum Tusculanum, 2007. http://www.mtp.dk/library/uni/kub/?isbn=978-87-635-0823-0.
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Reiff, Sean. "Utilizing Reversible Bruton’s Tyrosine Kinase Inhibitors to Circumvent Acquired Resistance to Ibrutinib". The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1523372591057698.
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Mallet, Dominique, i Muḥammad ibn Muḥammad Abū Naṣr al Fārābī. "La dialectique dans la philosophie d'Abū Naṣr al-Fārābī". Bordeaux 3, 1992. http://www.theses.fr/1992BOR30026.
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La these comprend, outre une etude sur la place de la dialectique dans la logique et dans la philosophie d'al-farabi (m. 950 ap. J. -c. ) l'edition critique a partir de cinq manuscrits du xviie et la traduction francaise annotee de deux traites, le k. Al-gadal (la dialectique) et le k. Al-tahlil (la resolution), attribues a al-farabi et expliquant, pour le premier les livres i et viii des topiques d'aristote, et pour le second le livre ii du meme traite de l'organon. L'etude montre que ces deux textes temoignent d'une ancienne redistribution du contenu des topiques : le second de leurs huit traites, consacre aux "lieux de l'accident", fut annexe aux premiers analytiques i, 27-30 pour leur fournir une "theorie des premisses" percue (malgre le contenu des categories et du de interpretatione) comme manquante; il venait ainsi completer la theorie des syllogismes qui s'y trouvait. Outre la construction de cette theorie originale des "lieux", les topiques fournirent le motif d'une reinterpretation de la dialectique dans le contexte d'une revendication, de la part des falasifa de l'heritage de la philosophie grecque et hellenistique : la dialectique devient l'instrument privilegie de l'enseignement aux arabes et dans leur langue d'une philosophie menacee par les clercs de l'islam et de l'"arabite". La dialectique permet de rendre sensible dans la grammaire des arabes les partages de la logique et d'illustrer, par des exemples qui leur sont familiers, les lois de la raison. Elle donne en outre au philosophe la cle qu'il lui faut pour faire, a la theologie musulmane, une place dans le dispositif de sa philosophie politiqueThis thesis contains a new edition and a french annotated translation of two alfarabi's logical treatises about dialectic. The first one (one dialectic) is the introductive part (i, 1-12) of an extended commentary of aristotle's topics i & viii; the second one (on resolution) is a brief survey of topics ii taken as an explicative part of prior analytics i, 27-30 : the topoi are supposed to provide prior analytics with the theory of premisses they need it. These two treatises have to be perceived as an historical testimony of a medieval "re-interpretation" concerning aristotle's logical works. Volume i of this thesis is devoted to a extensive study about alfarabi's recently edited logical treatises, sending new light on place and status of dialectical methods of teaching (and learning) classical greek & hellenistic patrimony as an arabic inheritance. This study supplys also medieval arabic philosophy's history with a serious examination of epistemological status of "dialectical theology" in alfarabi's political philosophy
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Ouahrani, Ali. "Conception et réalisation d'un outil de recherche appliquée à la traduction française du Sahîh al-Bukhârî proposée par O. Houdas et W. Marçais". Lille 3, 2005. http://www.theses.fr/2005LIL30040.
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Le Sahîh d'al-Bukhârî est considéré dans le monde musulman sunnite comme le deuxième livre après le Coran. La version française de O. Houdas se présente en 4 volumes pour 2707 pages. Les quatre tomes se divisent en 97 "livres" formés de 3450 "chapitres" regroupant 7563 hadîth-s traditions. Les textes du Sahîh abordent des domaines multiples tels que ceux du dogme, des rapports sociaux, du droit canon, des actes d'adoration, de l'histoire religieuse. Notre objectif est de mettre à la disposition des chercheurs, professeurs et étudiants non familiers de la langue arabe, un outil de recherche pratique et efficace qui leur permettra d'exploiter le Sahîh en leur facilitant l'accès aux données qu'il contient. O. Houdas n'ayant pas pu faire ce travail, nous nous proposons de réaliser à la suite de travaux préalables, un outil de recherche composé d'une quinzaine d'index (index : thématique, des traditions, des noms de prophètes, d'hommes, de femmes, de transmetteurs, des groupes humains, des lieux, des sourates du Coran, des versets du Coran, une table synoptique des titres, index des poésies). La thèse se présentera en trois parties essentielles : 1)Présentation et étude des versions arabes et françaises du Sahîh 2) Conception de l'outil et définition de son champ d'application 3) Construction de l'outil de recherche. Des notes introductives insérées sous les entrées onomastiques et thématiques enrichiront les index pour les faire évoluer vers des dictionnaires index de recherche
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Echevarria, Jaime Iris Deivi. "Propuesta de estrategias metodológicas que favorecen el manejo del clima de aula para mejorar el aprendizaje de los niños y niñas de la I. E. I. 087 Llícuar - Sechura”: plan de acción". Bachelor's thesis, Pontificia Universidad Católica del Perú, 2018. http://tesis.pucp.edu.pe/repositorio/handle/123456789/11120.
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El concepto de práctica educativa se reduce muchas veces a la enseñanza del docente, su estilo, experiencia y saberes; sin embargo, este concepto parece no involucrar el uso de las estrategias didácticas y materiales educativos disponibles. Tampoco, se conecta a la familia con los aprendizajes y la formación para la vida, por ello es necesario revalorar el uso de estrategias didácticas, recursos y materiales no estructurados en la educación básica regular, y así fortalecer las capacidades docentes, en la aplicación de estrategias metodológicas, activas para promover el pensamiento crítico reflexivo de los estudiantes, e incentivar el adecuado uso de recursos y materiales mejorando así, el desarrollo de capacidades, con el involucramiento familiar en las tareas escolares, lo cual facilitará la implementación y ejecución de un plan de refuerzo escolar para estudiantes con dificultades en los aprendizajes, propiciando así el trabajo colegiado a través de la formación de comunidades profesionales de aprendizaje, y contribuir a un clima escolar favorable como escenario alternativos de aprendizaje.
La teoría nos ayuda con esta experiencia, pues Investigadores como Arce (2016) afirman que los estudiantes no logran aprendizajes significativos y presentan bajo rendimiento académico y desmotivación debido al uso de métodos tradicionales, y la no utilización del entorno natural como recurso didáctico; por ello, Hernández (2014) también afirma que es necesario el uso de estrategias metodológicas activas porque estás facilitan el aprendizaje Así mismo, la implementación de este plan de acción pretende alcanzar que el 50 % de los docentes modifiquen sus prácticas pedagógicas y utilicen: estrategias didácticas y metodológicas activas y significativas; materiales estructurados y no estructurados, desarrollen sesiones de clase fuera del aula tradicional, y reafirmar así que el rol del directivo como líder pedagógico, es clave para promover el compromiso de la comunidad educativa y a lograr proyectos sostenibles.Trabajo académico
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Martins, Ana Sofia da Fonseca Costa. "Promoção de um ambiente seguro em pediatria". Master's thesis, [s.n.], 2012. http://hdl.handle.net/10400.26/16128.
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