Letteratura scientifica selezionata sul tema "Zheng Pingru"

In this paper, the culture and origins of the Shau Aborigines of Sun Moon Lake in Central Taiwan are examined. Conclusions presented in this article depend on clues from documents and long-term observation, that reveal that the characteristics of the Shau Aborigines are quite different from those of other aboriginal inhabitants of Taiwan. They lived on islands for a long time, were good at trading, and had a high material living standard, versatile language, and facial features similar to Western people. It is assumed from many reasonable interpretations of questions concerning their cultural characteristics that they may be descended from Dutch preachers and their families in Shaulon, Tainan, who married local Pingpu Aborigines. The Shau fled from Soulang when Zheng Chen-Kung (also known as Coxinja) attacked in 1661, moving to Mattauw, then to Dorcko, Tilaossen, and finally to Lehyee, the territory of Chou Aborigines, where they settled at Laichi for a time. When they discovered Sun Moon Lake, they moved to its island where they are today.

Primula pingbaensis Na Zhang, X.Q.Jiang & Z.K.Wu, a new species of Primulaceae from Gaofeng Mountain of Pingba county, Guizhou, China, is described and illustrated. Morphological evidence supports P. pingbaensis as a member of P. sect. Petiolares on account of scape elongating, pedicels conspicuously thickening in fruit, and its capsule cracking irregularly round the top and crumbling away. Amongst the members of subsect. Davidii, the new species is characterized by having a uniquely smooth leaf blade due to inconspicuously raised veinlets and homostylous flowers with the style usually extending beyond the anthers. The distribution, phenology and conservation status of the new species are also provided.

Abstract Background: Tumor-associated antigens and neoantigens serve as primary targets for cancer immunotherapies such as vaccines and T-cell based therapy. However, identifying pancreatic ductal adenocarcinoma (PDAC) associated T-cell epitopes have been challenging due to its low genomic mutational burden. In this study, we attempted to directly identify PDAC T-cell epitopes by using mass spectrometry. Methods: The protein lysate from PDAC specimens and cell lines were subjected to the antibody affinity purification of human major histocompatibility complexes (MHC) including both HLA Class I and Class II complexes. Peptides bound to the MHC were eluted and identified through LC-MS/MS. Peptide sequences were analyzed with MAXQUANT and Novor Denovo. HLA-binding affinity of peptides were predicted using NetMHC4.0 and validated by in vitro T2 binding assays. Their ability to induce T cell response were measured in a cytokine-Flurospot assay. TCRs specific for selected peptides were cloned by single-cell TCR sequencing and their anti-PDAC activity were tested in vivo on the patient-derived xenograft(PDX) models. Results: We identified 6553 unique HLA-I bound 9-mer peptides from eight PDAC specimens and two PDAC cell lines (Panc10.05 and Pan06.03). Among them, 1163 peptides and 1354 proteins were found in two or more PDAC specimens. We identified 8 potentially immunogenic peptides that bind strongly to matched and nonmatched HLA molecules and induced T cell response in peripheral T cells from both HLA-type matched and non-matched patients. We also identified HLA-II bound peptides in six PDAC tissues and found that the HLA-I and HLA-II peptides isolated from the same patient are highly overlapped. These overlapped peptides were able to induce polyfunctional cytokine response (IFN-γ, TNF-α, and IL-2) in peripheral T cells from patient PBMC. We further investigated the anti-tumor capability of T cell receptors (TCR) for an LAMC-2 derived HLA-class I epitope and a TMSB10 derived peptide eluted from both HLA-Class I and Class II affinity purification. Immunohistochemistry revealed both proteins to be more highly expressed in PDAC tissue compared to paranormal normal tissue. We stimulated HLA-type matched patient’s PBMC with LAMC-2 and TMSB10 peptides to induce clonal expansion of epitope-specific CD8+ and CD4+ T-cells, respectively. We subsequently performed single-cell TCR sequencing of these expanded T cells and infected Jurkat cells with the lentivirus expressing TCR of interest. Mice with orthotopically implanted PDAC tumors that were treated with Jurkat cells expressing LAMC-2 specific cells showed significant slowdown tumor growth. We are currently in the processing of testing TMSB10 peptide targeting TCRs. Conclusion: This study provides a novel venue for identifying T cell epitopes in a nonimmunogenic tumor such as PDAC for the design and development of cancer vaccine and T cell therapy. Citation Format: Tengyi Zhang, Jianxin Wang, Yingkuan Shao, Pan Li, Nan Niu, Brian Herbst, Jessica Gai, Juan Fu, Pingbo Zhang, Jun Yu, Kenji Fujiwara, Lei Zheng. Direct identification of MHC class I and class II epitopes for TCR-based T cell therapy for pancreatic cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr LB099.

A preliminary study to determine the group of compound contained in the ethanolic extract of mahagony (Swietenia mahagoni L. Jacq.) seeds and its inhibitory activity to a-glucosidase enzyme has been done. The information from this study will be used in the further investigation about the specific constituents related to the bioactivity. The seed was grounded and then extracted with ethanol by maceration technique. The crude extract was separated with liquid-liquid extraction by using n-hexane, ethyl acetate, and methanol as the solvents. The best eluent for isolation, chloroform:ethanol (1:1), was determined by thin layer chromatography while alumina as stationary phase. The isolation step with column chromatography gave two types of isolates, yellow and colorless isolate. In order to get information about the compound, the crude extract was subjected to phytochemical assignment and the isolate with the better activity was analyzed by infrared spectroscopy. The inhibitory activity for the yellow isolate with IC50 as 19.345 ppm was better than the colorless isolate. Therefore, the IR spectroscopy assay was subjected to the yellow isolate. Based on the comparison IR spectra with literatures, it has suggested that the yellow isolate contains tetranortriterpenoid or limonoid group.Keywords: Swietenia mahagoni L. Jacq., diabetes type 2, a-glucosidase, tetranortriterpenoidREFERENCE World Health Organization. Global report on diabetes. http://www.who.int. Accessed on 18 July 2017.Kementerian Kesehatan Republik Indonesia. 2014. Situasi dan analisis diabetes. Jakarta: Pusat Data dan Informasi Kemenkes RI.Dutta, M., Raychaudhuri, U., Chakroborty, R., and Maji, D. 2011. Role of diet and plants on diabetic patients - a critical appraisal. Science and Culture. 77 (3–4).Eid, A.M.M., Elmarzugi, N.A., and El-Enshasy, H.A. 2013. 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In June 2021, bacterial stem rot-like symptoms were observed on the stems and leaves of watermelon (Citrullus lanatus cv. ‘Zaojia’) in Pingyu County, Zhumadian City, Henan Province, China (32.44N 114.24E), which showed brown to dark brown lesions on the stems (Fig. 1A). The stems then became scorched, and the leaves showed necrotic lesions with small water-soaked spots (Fig. 1B). Watermelon is a very important economic plant in this small county, where the watermelon planting area accounts for about 15% of the arable land area. Approximately 2 hectares of ‘Zaojia’ have been investigated, and the disease incidence rates were almost 20~30%, thus, causing severe economic losses. Ten symptomatic watermelon stems and leaves were randomly collected based on the typical symptoms, brought into the Lab and used to isolate the pathogen. Each infected tissue was excised and cut into small pieces (about 5 mm×5 mm) and surface disinfected with 1% NaClO for 3 min. The pieces were then rinsed three times in sterile distilled water (SDW) and dried by airing. These pieces (4-5 pieces per sample) were macerated in 200 μL SDW for 60 s in a sterile mortar and pestle. A volume of 5 μL suspensions of each sample were streaked onto two LB agar plates and incubated for 48 h at 28 °C in the dark. After incubation, the colonies on LB agar plate were small, round, raised, white to cream-colored, and had smooth margins (Fig. 2). Two strains from each plate were selected. The genomic DNA of all 40 strains was extracted using a Bacterial Genomic DNA Extraction Kit D1600 (Beijing Solarbio Science & Technology Co., Ltd., Beijing, China) according to the manufacturer's instructions. The 16S ribosomal RNA gene (27F:5'-AGA GTT TGA TCC TGG CTC AG-3', /1492R: 5'-CTA CGG CTA CCT TGT TAC GA-3'), and the three housekeeping genes, including gyrB (Trantas et al., 2013), icdA and proA (Ma et al., 2007), were amplified. Sequence analysis showed that 40 strains shared the same sequence, so only one sequence was submitted into GenBanK.The 16s rDNA partial sequences (SUB12134746) shared 100% similarity with E.mori (CP084692.1), and the gyrB (OP676246), icdA (OP676248) and proA (OP676247) genes shared 98.67%, 99.39% and 97.99% homology with those of E. mori (CP084692.1), respectively. Besides, the phylogenetic tree analysis based on multi-housekeeping gene joint gryB-icdA-proA showed that E.mori（OP676246-OP676248- OP676247）from watermelon was culsterd with the E.mori (CP084692.1) from South Korea and E.mori (CP055276.1) from kiwifruit (Fig. 3). Thus, E.mori was confirmed to be the pathogen responsible for bacterial soft rot of watermelon in this study. To confirm the pathogenicity, 15-day-old healthy cv. ‘Zaojia’ watermelon seedlings were inoculated by spraying all the seedlings with a bacterial suspension (1×10 8 CFU mL-1) at an incubation temperature of 28 °C and 70% relative humidity, and sterile distilled liquid LB medium was applied as a negative control treatment. Three times were conducted for the isolate, and each time included nine watermelon plants. After 10 days, only the inoculated cotyledons and leaves with the bacterial suspension showed bacterial leaf spots that resembled those observed on naturally infected watermelon cotyledons and leaves (Fig. 4A-C), whereas the control plants remained asymptomatic (Fig. 4D). Simultaneously, the watermelon stems were inoculated with the bacterium in vitro. Each stem was slightly wounded with a metal sponge and then sprayed with the bacterial suspension (108 CFU mL-1) of each isolate, and the experiment was repeated three times. Water-soaked symptoms were visible on the stems (Fig. 4E), while the control plants remained asymptomatic (Fig. 4F). The strains were then successfully re-isolated and identified by sequence analyses of their 16S ribosomal RNA gene and gyrB, icdA and proA genes. Therefore, the inoculation experiment of the isolatedbacterium fulfilled Koch’s postulates. Previously, E. mori has been reported to cause bacterial wilt on white mulberry (Morus alba L.) (Zhu et al. 2022), peach fruit (Prunus persica) (Ahmad et al. 2021) and kiwifruit (Actinidia deliciosa [A. Chev.] CF Liang et AR Ferguson) (Zhang et al. 2021). To our knowledge, this is the first report of E. mori causing bacterial soft rot on watermelon in world.

This dissertation is about Chinese masculinity. It will raise the issue of Chinese masculinity as it became problematic in the mid-1980s, the first time in the twothousand- year history of Chinese literature, that problems such as male identity, sexuality, and masculinity were seriously formulated and discussed. This study adopts the methods of a feminist reading and a close reading to reexamine works of three well-known contemporary male writers: Zhang Xianliang, Mo Yan and Jia Pingwa in the ideological/cultural context of the resurgence of Confucian patriarchy during the mid- 1980s to the mid-1990s in China. I will provide a detailed and dynamic analysis of how the contemporary male enterprise of reconstructing masculinity heavily relies on women—either by programming women into the author's step-by-step process of reconstructing lost masculinity for the protagonist or by putting women back to their old place prescribed by Confucian patriarchy. By deepening our understanding of Chinese men and women historically, culturally, ideologically and psychologically, and by constructing a dialogue between the past and the present, this study attempts to demonstrate that ideal masculinity in China as defined two thousand years ago is still alive, and serves as a major paradigm of masculinity for modern Chinese intellectuals. The re-examinations of each of the three works will be structured around the following three topics: (1) the major source of men's feelings of powerlessness and feminization (2) the ideological framework from which their ideal concept of masculinity is reconstructed; and (3) how these frameworks establish their gendered position and affect their views and feelings toward women; and thus how they program women's roles into the construction or restoration of their masculinity. My research reveals a stable structure to authors' ideals of masculinity consisting of four constant elements: power is the key attribute in defining Chinese masculinity; hierarchy is the structure within which ideal masculinity is constructed and consolidated; the state, (including politics and nationalism), male intellectuals and women are three indispensable, intertwined dimensions within which male intellectuals maneuver to bargain for their masculinity; and the philosophical/ideological past is the inexhaustible source of inspiration and justification for restoring lost masculinity.
Arts, Faculty of
English, Department of
Graduate

The book’s conclusions return to the premises of the first chapter. The zheng’s history began to be configured by reformers on the Chinese mainland in the 1920s and 30s. Cao Zheng and Liang Tsai-ping were among the zheng experts involved in this effort. The Chinese Communist Party promoted a new ideology for music and the other arts, maintaining that they needed to serve the people. This effort involved “cai feng”: collecting folk music, notating, and sometimes recording it. The very act of notating this music was a consequential step for the music of the zheng. In many cases, it had not been created with the zheng in mind. Although much zheng music was formerly improvised and likely accompanied songs, solo zheng music became the best-known type of zheng music in the twentieth century. Lacking access to the mainland and its massive store of traditional Chinese music, Taiwanese zheng music incorporated creative new compositions. The continuity of historic zheng music is possibly best represented by singer-players such as Cao Dongfu, a master of Henan dadiao quzi, andDou Wun (who sang naamyam in Hong Kong).

In Taiwan, the zheng’s most notable and best understood history began after the Nationalists fled to the island under the leadership of Chiang Kai-shek. Liang Tsai-ping was possibly the most important and best-known zheng expert who emigrated to Taiwan in 1949. He expanded the international renown of the zheng, travelling to Europe and the United States over the course of many years. Liang composed new solo music for the zheng, but he adhered to traditional zheng playing techniques and continued to use a type of zheng with sixteen metal strings and tuning pegs inserted vertically into the soundboard. Changes to the zheng’s repertory, technique, and structure implemented on the mainland were largely unknown in Taiwan until the early 1970s because direct imports from the mainland were forbidden. Taiwanese zheng musicians began to learn of these changes through third parties, including musicians from Hong Kong, Malaysia, and Singapore.

This chapter provides a broad overview of popular Chinese literature during the wartime years, including relevant historical context, such as the attempt at reconciliation between different factions and groups of writers in October 1936. Several authors are discussed, including Zhang Henshui, Ping Jinya, Jin Yi, Wang Dulu, Qin Shou’ou, Zhang Ailing, Cheng Xiaoqing, and Yu Qie. It demonstrates that the popular literature of the time was highly diverse and frequently explored aspects of tradition, modernity, nationalism, character psychology and various narrative styles. Tradition and history were freed from being seen as the enemies of progress and were now used for playful entertainment as well as fostering national pride. Overall, the wartime period saw a collapse of the formerly sharp distinction between “new” and “old” literature and this allowed numerous authors to straddle such divides in novel ways.

Xiang-Ping Hu and Zhuo Zheng of the Dalian Institute of Chemical Physics developed (Organic Lett. 2009, 11, 3226; J. Org. Chem. 2009, 74, 9191) a family of Rh catalysts for the enantioselective hydrogenation of allylic phosphonates such as 1. Hon Wai Lam of the University of Edinburgh established (J. Am. Chem. Soc. 2009, 131, 10386) that an alkenyl heterocycle 3 could be reduced with high ee. The product 4 could be hydrolyzed to the carboxylic acid. Ken Tanaka of the Tokyo University of Agriculture and Technology showed (J. Am. Chem. Soc. 2009, 131, 12552) that an isopropenyl amide 6 could be hydroacylated with high ee. Gregory C. Fu of MIT observed (J. Am. Chem. Soc. 2009, 131, 14231) that nitromethane 9 could be added to the allenyl amide 8 to give 10, the product of γ-bond formation. Robert K. Boeckman Jr. of the University of Rochester devised (Organic Lett. 2009, 11, 4544) what appears to be a general protocol for the construction of alkylated ternary and quaternary centers: enantioselective hydroxymethylation of an aldehyde 11. In another approach to the construction of alkylated quaternary centers, Varinder K. Aggarwal of the University of Bristol demonstrated (Angew. Chem. Int. Ed. 2009, 48, 6289) that an enantiomerically enriched trifluoroborate salt 14 could be added to an aromatic aldehyde 15 with retention of absolute configuration. The salt 14 was prepared from the corresponding high ee secondary benzyl alcohol. Weinreb amides are versatile precursors to a variety of functional groups. Stephen G. Davies of the University of Oxford devised (Organic Lett. 2009, 11, 3254) a chiral Weinreb amide equivalent 17 that could be alkylated with high de. The minor diastereomer from the alkylation was readily separable by silica gel chromatography. Keiji Maruoka of Kyoto University established (Angew. Chem. Int. Ed. 2009, 48, 5014) that a chiral phase transfer catalyst was effective for the enantioselective alkylation of the alkynyl ester 19. Emmanuel Riguet of the Université de Reims Champagne-Ardenne developed (Tetrahedron Lett. 2009, 50, 4283) an improved catalyst for the enantioselective addition of malonate 22 to cyclohexenone 21.

Jianbo Wang of Peking University described (Angew. Chem. Int. Ed. 2010, 49, 2028) the Au-promoted bromination of a benzene derivative such as 1 with N-bromosuccinimide. In a one-pot procedure, addition of a Cu catalyst followed by microwave heating delivered the aminated product 2. Jian-Ping Zou of Suzhou University and Wei Zhang of the University of Massachusetts, Boston, observed (Tetrahedron Lett. 2010, 51, 2639) that the phosphonylation of an arene 3 proceeded with substantial ortho selectivity. Yonghong Gu of the University of Science and Technology, Hefei, showed (Tetrahedron Lett. 2010, 51, 192) that an arylpropanoic acid 6 could be ortho hydroxylated with PIFA to give 7. Louis Fensterbank, Max Malacria, and Emmanuel Lacôte of UMPC Paris found (Angew. Chem. Int. Ed. 2010, 49, 2178) that a benzoic acid could be ortho aminated by way of the cyano amide 8. Daniel J. Weix of the University of Rochester developed (J. Am. Chem. Soc. 2010, 132, 920) a protocol for coupling an aryl iodide 10 with an alkyl iodide 11 to give 12. Professor Wang devised (Angew. Chem. Int. Ed. 2010, 49, 1139) a mechanistically intriguing alkyl carbonylation of an iodobenzene 10. This is presumably proceeding by way of the intermediate diazo alkane. Usually, benzonitriles are prepared by cyanation of the halo aromatic. Hideo Togo of Chiba University established (Synlett 2010, 1067) a protocol for the direct electrophilic cyanation of an electron-rich aromatic 15. Thomas E. Cole of San Diego State University observed (Tetrahedron Lett. 2010, 51, 3033) that an alkyl dimethyl borane, readily prepared by hydroboration of the alkene with BCl3 and Et3 SiH, reacted with benzoquinone 17 to give 18. Presumably this transformation could also be applied to substituted benzoquinones. When a highly substituted benzene derivative is needed, it is sometimes more economical to construct the aromatic ring. Joseph P. A. Harrity of the University of Sheffield and Gerhard Hilt of Philipps-Universität Marburg showed (J. Org. Chem. 2010, 75, 3893) that the Co-catalyzed Diels-Alder cyloaddition of alkynyl borinate 21 with a diene 20 proceeded with high regiocontrol, to give, after oxidation, the aryl borinate 22.