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1
Henricks, Robert G. "On the whereabouts and identity of the place called ‘K'ung-Sang’ (Hollow Mulberry) in early Chinese mythology". Bulletin of the School of Oriental and African Studies 58, n. 1 (gennaio 1995): 69–90. http://dx.doi.org/10.1017/s0041977x00011861.
Testo completoAbstract (sommario):
One of the places that plays a role in a number of myths and legends that survive from ancient China is the place called K'ung-sang , Hollow Mulberry. Confucius is said to have been born in a place called K'ung-sang, and Yi Yin, the man who served as chief minister to T'ang, founder of the Shang or Yin dynasty (traditional reign dates, 1766–1753 b.c.) was born in an actual hollow mulberry tree. By force of the Confucius connexion, commentaries often identify K'ung-sang as a place in the state of Lu, if not precisely Ch'ü-fu, the home town of Confucius. But K'ung-sang is located and identified in a number of ways in early texts: it is a mountain in the North or the East; it is a place that is being attacked by a demon; it is the capital of various Ti (emperors or gods); and in one source at least, it is the name of a musical instrument, a zither (se).
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Pan, Chun-Hsu, I.-Chun Hsieh, Fon-Chang Liu, Wen-Tsong Hsieh, Ming-Jyh Sheu, Ayano Koizumi e Chieh-Hsi Wu. "Effects of a Chinese Herbal Health Formula, “Gan-Lu-Yin”, on Angiogenesis". Journal of Agricultural and Food Chemistry 58, n. 13 (14 luglio 2010): 7685–92. http://dx.doi.org/10.1021/jf1002254.
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Nienling, Liu. "The Vanguards of the Women's Liberation Movement—Lu Yin, Bingxin, and Ding Ling". Chinese Studies in History 23, n. 2 (dicembre 1989): 22–45. http://dx.doi.org/10.2753/csh0009-4633230222.
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Wan, Fang. "Dominated Females: Lu Yin’s The Heart of Women and the New Woman". Asian Culture and History 14, n. 1 (25 febbraio 2022): 1. http://dx.doi.org/10.5539/ach.v14n1p1.
Testo completoAbstract (sommario):
China’s political, social and cultural environment during the 1920s and 1930s shaped the ‘new woman’ notion, which was a crucial dynamic of female liberation during the May Fourth era. In Lu Yin’s novel The Heart of Women (Nüren de xin 女人的心), the image of new woman is secondary to the cause of China’s modernisation in a male-dominated May Fourth discourse. This essay will explore this position from three perspectives. The construction of the new woman during the May Fourth era characterises the first point. The second is male-dominated discourse of modern identity and new woman in the May Fourth literature. Male lead in The Heart of Women is the third aspect.
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Wu, Po-Chang, Shih-Chao Lin, Lauren Panny, Yu-Kang Chang, Chi-Chien Lin, Yu-Tang Tung e Hen-Hong Chang. "Effect of the Chinese Herbal Medicine SS-1 on a Sjögren’s Syndrome-Like Disease in Mice". Life 11, n. 6 (7 giugno 2021): 530. http://dx.doi.org/10.3390/life11060530.
Testo completoAbstract (sommario):
Sjögren’s syndrome (SS) is an inflammatory autoimmune disease primarily affecting the exocrine glands; it has a major impact on patients’ lives. The Chinese herbal formula SS-1 is composed of Gan Lu Yin, Sang Ju Yin, and Xuefu Zhuyu decoction, which exerts anti-inflammatory, immunomodulatory, and antifibrotic effects. Our previous study demonstrated that SS-1 alleviates clinical SS. This study aimed to evaluate the efficacy and mechanism of the Chinese herbal formula SS-1 for salivary gland protein-induced experimental Sjögren’s syndrome (ESS). These results showed that ESS treatment with the Chinese herbal formula SS-1 (1500 mg/kg) significantly alleviated the severity of ESS. We found that SS-1 substantially improved saliva flow rates in SS mice and ameliorated lymphocytic infiltrations in submandibular glands. In addition, salivary gland protein-induced SS in mice treated with SS-1 significantly lowered proinflammatory cytokines (including IFN-γ, IL-6, and IL-17A) in mouse salivary glands and decreased serum anti-M3R autoantibody levels. In addition, we found that CD4+ T cells isolated from SS-1-treated SS mice significantly reduced the percentages of IFN-γ-producing CD4+ T cells (Th1) and IL-17A-producing CD4+ T cells (Th17). Our data show that SS-1 alleviates ESS through anti-inflammatory and immunomodulatory effects, which provides new insight into the clinical treatment of SS.
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Cheng-Sheng, Tu. "28. Some Problems Concerning the So-Called Survivors of the Yin Dynasty". Early China 9, S1 (1986): 58–60. http://dx.doi.org/10.1017/s0362502800003151.
Testo completoAbstract (sommario):
ABSTRACTThe basic error in Hu Shi's “An Exposition on Confucians” lay in discussing the basic nature of the Confucian school on the basis of the “tragic fate and miserable status of the survivors of the Shang”; for half a century this mistaken premise has been accepted by most historians as proven. On the basis of an analysis of pre-Qin literary sources, this paper first proves that there was no “tragedy of the defeated state”; on the contrary, the Yin survivors continued to possess considerable political power and quite high social status. Second, on the basis of newly un earthed Shang and Zhou inscriptions, the fate and status of the Shang survivors is set forth from three sides: (1) The history of the Wei Shi clan and Lu Sheng clan of the Guanzhong region, for which genealogies of seven-eight or six-seven generations exist, is reconstructed on the basis of, for the former, the Ding bronze horde newly unearthed from Fufeng Zhuangbai, and, for the latter, the inscriptions on already known as well as recently unearthed bronze vessels from the same area. Both clans were survivors from the Shang and close relatives of the Shang king; they possessed cities, subjects, and official positions, as well as holding offices in charge of troops. (2) The same conclusion may be reached in individual cases in various other kingdoms, such as for Mo Situ Sung of the state of Wei , and Dong Hefu of the state of Yan . As for the Ling Shi , Chen Chen and Deng of Cheng Zhou , Cheng Zhou is the ancient home of the Shang survivors, yet they seem not to have been the object of any special restriction or suppression. This section is based solely on inscriptions; the conclusions reached, however, are completely in agreement with those derived from literary evidence in the previous section. Finally an attempt is made to explain why the survivors of the Shang had land, subjects, offices, and power. We believe that it was due to a political and social structure with the clan as the primary unit. A complete explication of this question awaits a detailed study of oracle-bone and archaeological source material.
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Zhang, Ming. "Professor LU De-Ming's experience in clinical application of the method for replenishing qi and nourishing yin". Journal of Chinese Integrative Medicine 3, n. 2 (15 marzo 2005): 141–43. http://dx.doi.org/10.3736/jcim20050217.
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Zhang, Mengzhe. "POLYPHONIC GENRES IN PIANO CREATIVITY OF CHINESE COMPOSERS". Aspects of Historical Musicology 24, n. 24 (13 ottobre 2021): 148–65. http://dx.doi.org/10.34064/khnum2-24.08.
Testo completoAbstract (sommario):
Statement of the problem. The twentieth century marked an increased interest in polyphonic music. The geography of polyphonic works for piano expanded significantly and a creative development of many Chinese composers, writing polyphonic piano pieces, took place. Today, polyphonic pieces make up a significant part of the piano repertoire in China, but they are little studied by musicologists and performers. The objective of this study – to reveal the contribution of Chinese composers to the creation of polyphonic piano repertoire of the XX – early XXI century. Analysis of the research and publications on the theme. А large number of modern authors study polyphony from the point of physical and mathematical research methods (Igarashi, Yu. & Ito, Masashi & Ito, Akinori, 2013; Weiwei, Zhang & Zhe, Chen, & Fuliang, Yin, 2016; Li, Xiaoquan et al. others, 2018). This approach does not reveal the factual musical component of polyphonic genres. In the 20th century, musicologists explored polyphony in musical folklore (Wiant, 1936; Fan Zuyin, 2004; Li Hong, 2015) and in professional Chinese composing (Sun Wei-bo, 2006, Winzenburg, 2018). The scientific novelty. This article studies the role of Chinese composers in the development of the world polyphonic piano repertoire of the XX – early XXI century. The methodological basis for the analysis of polyphonic works was the theoretical concepts of P. Hindemith, Peng Cheng, Fang Zuin, Li Hong, Sun Wei-bo. The results of the study. The research outcomes demonstrate the evolutionary development of the genre diversity of Chinese piano polyphony as well as those composers who created magnificent musical pieces. Conclusions. Chinese composers have fully mastered the art of modern counterpoint, represented by the genres of polyphonic program pieces (He Lu Ting), invention (Xiao Shu Xian, Du Qian, Sun Yun Yin, Chen Chen Quang), polyphonic suite (Ma Gui), large polyphonic cycle ( He Shao, Chen Hua Do, Xiao Shu Xian), fugue (Li Jun Yong, Yu Su Yan, Chen Gang, Tian Lei Lei, Duan Ping Tai, Zheng Zhong, Xiao Shu Xian) and small cycle “Prelude and Fugue” (Ding Shan Te, Chen Zhi Ming, Wang Li Shan). Creatively assimilating and rethinking the experience of Western polyphonists, Chinese composers have filled their polyphonic works with national features, firmly linking them with the origins of Chinese traditional and folk music. The polyphonic way of transmitting musical material becomes the most expressive at the moments of profound creativity and musical dramatization.
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Yun, Eun-seol. "A study on Characteristics of the Mu Dan Ting Zhe Zi Xi in Shen Yin Jian Gu Lu". JOURNAL OF CHINESE HUMANITIES 63 (31 agosto 2016): 249–70. http://dx.doi.org/10.35955/jch.2016.08.63.249.
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Chow, Hei Ching, Tsz Him So, Horace Cheuk Wai Choi e Ka On Lam. "Literature Review of Traditional Chinese Medicine Herbs–Induced Liver Injury From an Oncological Perspective With RUCAM". Integrative Cancer Therapies 18 (gennaio 2019): 153473541986947. http://dx.doi.org/10.1177/1534735419869479.
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Traditional Chinese medicine (TCM) herbs are commonly regarded to be safe with minimal toxicities in Chinese communities. Cancer patients who are receiving Western oncology therapy often concurrently take TCM herbs for anticancer and symptom relief purposes. We performed a literature review for current evidence on TCM herb–induced liver injury from an oncological perspective. A literature search on PubMed was performed to identify publications regarding TCM herbs and concoctions with hepatoprotective or hepatotoxic properties. Lists of commonly used herbs and their causality levels were compiled. In view of the wide range of evidence available, cases assessed by the well-established RUCAM (Roussel Uclaf Causality Assessment Method) algorithm were categorized as the highest level of evidence. More than one case of TCM herb–induced liver injury was confirmed by RUCAM in the following herbs and concoctions: Lu Cha ( Camellia sinensis), Bai Xian Pi ( Dictamnus dasycarpus), Tu San Qi ( Gynura segetum), Jin Bu Huan ( Lycopodium serratum), He Shou Wu ( Polygoni multiflora), Ge Gen ( Pueraria lobata), Dan Lu Tong Du tablet, Shou Wu Pian, Xiao Chai Hu Tang, Xiao Yin pill, and Yang Xue Sheng Fa capsule. Finally, TCM with anticancer or symptom relief uses were discussed in detail with regard to their hepatotoxic or hepatoprotective properties.
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Alp, Hayriye. "Acupuncture Application in Seconder amenorrhea Obese female Patient". Obstetrics Gynecology and Reproductive Sciences 5, n. 04 (15 maggio 2021): 01–02. http://dx.doi.org/10.31579/2578-8965/072.
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Obesity is a disease caused by excessive fat storage in the body. It is an energy balance problem. Obesity can prepare the ground for many diseases. Secondary amenorrhea is the condition of not having menstruation for 6 months. In Traditional Chinese Medicine, it is thought to be caused by Qi and blood deficiency. The 43-year-old nurse applied due to obesity, inability to have menstruation, edema and nodules in goiter. TSH was 4.25, T3 2.87, T4 1.07mU/L. The 78.6 kg 150cm tall TA was 100/70 mmHg.Ten sessions of acupuncture were performed. Yin-tan, DU-20,21, LU-9, H-7, PC-6, SI-3, ST-24,25, REN-7,9, KID-3-6, SP -6.9 uterus, zero, jerome, shen-men hunger, kidney, points were pinned with disposable acupuncture needles. The patient, whose edema was resolved in the second session, started to have menstruation in the third session and lost 9kg in total. The patient had regular periods during the 1-year follow-up. TSH fell to 3.18mU/L.
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Hsieh, Ya Ju, Ming Hong Yen, Ya Wen Chiang, Chia Feng Yeh, Lien Chai Chiang, Den En Shieh, IJeng Yeh e Jung San Chang. "Gan-Lu-Siao-Du-yin, a prescription of traditional Chinese medicine, inhibited enterovirus 71 replication, translation, and virus-induced cell apoptosis". Journal of Ethnopharmacology 185 (giugno 2016): 132–39. http://dx.doi.org/10.1016/j.jep.2016.03.034.
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Lin, I.-Hsin, Ming-Chung Lee e Wu-Chang Chuang. "Application of LC/MS and ICP/MS for establishing the fingerprint spectrum of the traditional Chinese medicinal preparation Gan-Lu-Yin". Journal of Separation Science 29, n. 1 (gennaio 2006): 172–79. http://dx.doi.org/10.1002/jssc.200500147.
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Liu, Fon-Chang, Chun-Hsu Pan, Ming-Tsung Lai, Shu-Jen Chang, Jing-Gung Chung e Chieh-Hsi Wu. "Gan-Lu-Yin Inhibits Proliferation and Migration of Murine WEHI-3 Leukemia Cells and Tumor Growth in BALB/C Allograft Tumor Model". Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/684071.
Testo completoAbstract (sommario):
The aim of this study was to explore the antitumor effect of Gan-Lu-Yin (GLY), a traditional Chinese herbal formula, on leukemia. Ethanolic extract of GLY was applied to evaluate its regulatory mechanisms in proliferation, migration, and differentiation of WEHI-3 leukemic cells as well as antitumor effect on BALB/c mice model. The results showed that GLY markedly reduced cell proliferation and migration with induced differentiation of WEHI-3 cells. The expression level of phosphorylated FAK, Akt, ERK1/2, and Rb was decreased p21 expression while level was increased in WEHI-3 treated with GLY. The results of cell cycle analysis revealed that GLY treatment could markedly induce G1 phase arrest and decrease cell population in S phase. Moreover, experimental results demonstrated that GLY decreased the protein expression and enzyme activity of MMP-2 and MMP-9. GLY treatment also reduced WEHI-3 leukemic infiltration in liver and spleen and tumor growth in animal model. Accordingly, GLY demonstrated an inhibitory effect on tumor growth with a regulatory mechanism partially through inhibiting FAK, Akt, and ERK expression in WEHI-3 cells. GLY may provide a promising antileukemic approach in the clinical application.
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Fei, Huifang, Stefano Passerini e Alberto Varzi. "Stable Ammonium-Ion Batteries in Diluted Electrolyte By Manipulation of H-Bonding Network Via Ethylene Glycol". ECS Meeting Abstracts MA2023-02, n. 4 (22 dicembre 2023): 695. http://dx.doi.org/10.1149/ma2023-024695mtgabs.
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Aqueous rechargeable batteries (ARB) arose considerable interest for stationary energy storage due to low cost, inherent safety, and environmental friendliness.[1] Besides aqueous lithium-ion batteries, various kinds of aqueous batteries have been proposed, utilizing relatively inexpensive charge carriers either based on metal (Na+, K+, Ca2+, Mg2+, Zn2+, Al3+, etc.) or non-metal cations (H3O+, NH4 + etc.).[2] Among non-metallic ion batteries, aqueous ammonium-ion batteries (AAIBs) distinguish themselves by working in near neutral or mild acidic environment, refraining from severe electrode corrosion.[3] However, like other ARB systems, the energy density of AAIBs is limited by the narrow electrochemical stability window of the aqueous electrolyte. In addition, NH4 + ions hydrolyse in water resulting in decreased pH of the electrolyte which promotes the hydrogen evolution reaction (HER).[3] This means that increasing salt concentration may not be an effective strategy to enlarge the stability window of the electrolyte. In fact, according to a previous report, the cathodic stability of 25 m ammonium acetate (NH4Ac) is even slightly inferior than that of 1 M NH4Ac.[4] Developing alternative strategies to inhibit HER in diluted electrolytes is of uttermost importance. In diluted aqueous electrolytes, the continuous and complicated H bond network among water molecules favours fast ionic motion but also causes severe HER. Here, we propose ethylene glycol (EG) as electrolyte component to manipulate the H bond structure in diluted (1 m) NH4Ac solutions. FTIR results are used to study the H-bonding network as function of the EG:water ratio. The diluted aqueous electrolyte containing EG show no freezing point and wider electrochemical window. As a proof-of-concept, full cells composed of Prussian blue derivatives, PTCDI anode, and 1 m NH4Ac with the addition of EG are tested to verify the effectiveness of EG during battery operation. Improved cycling performance and higher coulombic efficiencies are demonstrated compared to those including 1 m NH4Ac in water. References [1] Wang, Y.; Wang, T.; Dong, D.; Xie, J.; Guan, Y.; Huang, Y.; Fan, J.; Lu, Y.-C. Enabling high-energy-density aqueous batteries with hydrogen bond-anchored electrolytes. Matter 2021. DOI: 10.1016/j.matt.2021.10.021. [2] Zheng, R.; Li, Y.; Yu, H.; Zhang, X.; Ding, Y.; Yan, L.; Li, Y.; Shu, J.; Su, B. L. Ammonium Ion Batteries: Material, Electrochemistry and Strategy. Angew Chem Int Ed Engl 2023, e202301629. DOI: 10.1002/anie.202301629. [3] Tian, Z.; Yin, J.; Guo, T.; Zhao, Z.; Zhu, Y.; Wang, Y.; Yin, J.; Zou, Y.; Lei, Y.; Ming, J.; et al. A Sustainable NH4+ Ion Battery by Electrolyte Engineering. Angew Chem Int Ed Engl 2022, 61 (51), e202213757. DOI: 10.1002/anie.202213757. [4] Holoubek, J. J.; Jiang, H.; Leonard, D.; Qi, Y.; Bustamante, G. C.; Ji, X. Amorphous titanic acid electrode: its electrochemical storage of ammonium in a new water-in-salt electrolyte. Chem Commun (Camb) 2018, 54 (70), 9805-9808. DOI: 10.1039/c8cc04713h.
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Yin, Yongmei, Xinhong Wu, Quchang Ouyang, Min Yan, Lihua Song, YunPeng Liu, Zhongsheng Tong et al. "Abstract PS08-08: Updated efficacy and safety of SKB264 (MK-2870) for previously treated metastatic triple negative breast cancer (mTNBC) in Phase 2 study". Cancer Research 84, n. 9_Supplement (2 maggio 2024): PS08–08—PS08–08. http://dx.doi.org/10.1158/1538-7445.sabcs23-ps08-08.
Testo completoAbstract (sommario):
Abstract Background: Patients (pts) with mTNBC have limited treatment options and poor prognosis. The estimated median overall survival (OS) of pts with mTNBC is 12 to 18 months (mo) after diagnosis. SKB264, an antibody drug conjugate (ADC) composed of an anti-TROP2 antibody coupled to a cytotoxic belotecan-derivative via a novel linker with an average Drug to Antibody Ratio (DAR) of 7.4, has shown promising anti-tumor activity and tolerable safety profile in pts with mTNBC (Yin, Y. et al. SABCS 2022). Here, we report the updated data from a Phase 2 expansion cohort for pts with mTNBC (NCT04152499). Methods: Pts with previously treated mTNBC were enrolled to receive SKB264 at 4 mg/kg Q2W or 5 mg/kg Q2W in a non-randomized manner until disease progression or unacceptable toxicity. Tumor assessment was performed every 8 weeks per RECIST v1.1 assessed by investigator. The primary objective was to assess objective response rate (ORR). Secondary objectives included DoR, PFS, and OS. The TROP2 expression was scored using the semi-quantitative H-score method, and a preliminary cutoff was set as 200. TROP2 expression and its association with anti-tumor activity were retrospectively analyzed. Results: At data cut-off date (May 05, 2023), 59 pts were enrolled (23 in 4 mg/kg, 36 in 5 mg/kg), and 88% (52 pts) had received ≥3 prior lines of therapy for metastatic disease. The median follow-up was 22.8 months (mo; 95% CI, 21.3-25.2). The ORR was 42.4% (25/59, 22 confirmed and 3 unconfirmed) and disease control rate (DCR) was 76.3% (45/59). The median duration of response (DoR) was 11.5 mo (range, 3.7 to 22.1+). Median PFS (mPFS) was 5.7 mo (95% Cl: 3.8, 9.1). Median OS (mOS) was 16.8 mo (95% Cl: 12.7, NE), while 12-mo and 24-mo OS rates were 65.0% and 39.5%, respectively. In the subset of pts with high TROP2 expression (H-score>200, N=32), ORR was 53.1% (including 3 complete response), mDoR was 11.1 mo (range, 3.7 to 22.1+), mPFS was 5.8 mo (95% Cl: 3.7, 13.3), mOS was not reached (95% Cl: 9.7, NE), while 12-mo and 24-mo OS rates were 65.3% and 57.3%, respectively. Treatment-related adverse events (TRAEs) of ≥ Grade 3 severity were reported in 57.6% (34/59) of pts. The most common ≥ Grade 3 TRAEs (≥ 10%) were neutrophil count decreased (25.4%), white blood cell count decreased (23.7%), anemia (22.0%) and platelet count decreased (16.9%). TRAEs leading to dose reduction and dose delay occurred in 13.6% (8/59) and 47.5% (28/59) of pts, respectively. Three pts discontinued treatment due to TRAEs (platelet count decreased, dry eye, anaphylactic shock). No cases of interstitial lung disease (ILD), neuropathy or grade ≥3 diarrhea were observed. Serious TRAEs were reported in 28.8% (17/59) of pts; no deaths associated with TRAEs were observed. Conclusions: The updated data continues to demonstrate that pts with heavily pretreated mTNBC could achieve durable response and a trend of long-term OS benefit from SKB264 treatment, along with a manageable safety profile. Higher response rate was seen in mTNBC pts with high TROP2 expression. A Phase 3 study of SKB264 vs. investigator’s choice of chemotherapy in 3L+ mTNBC (NCT05347134) and a Phase 2 study evaluating SKB264 as monotherapy or combination with anti-PD-L1 antibody in first-line setting (NCT05445908) are ongoing in China. Citation Format: Yongmei Yin, Xinhong Wu, Quchang Ouyang, Min Yan, Lihua Song, YunPeng Liu, Zhongsheng Tong, Cuizhi Geng, Ying Wang, Guohua Yu, Xiang Wang, Ying Cheng, Weihong Zhao, Xiaoping Jin, Yina Diao, Gesha Liu, Mengyu Yang, Yue Yang, Yalan Yang, Lian Lu, Junyou Ge, Jin Li, Qun Li. Updated efficacy and safety of SKB264 (MK-2870) for previously treated metastatic triple negative breast cancer (mTNBC) in Phase 2 study [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PS08-08.
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Inagaki, Yuji, Jun-ichi Kido, Yasufumi Nishikawa, Rie Kido, Eijiro Sakamoto, Mika Bando, Koji Naruishi, Toshihiko Nagata e Hiromichi Yumoto. "Gan-Lu-Yin (Kanroin), Traditional Chinese Herbal Extracts, Reduces Osteoclast Differentiation In Vitro and Prevents Alveolar Bone Resorption in Rat Experimental Periodontitis". Journal of Clinical Medicine 10, n. 3 (20 gennaio 2021): 386. http://dx.doi.org/10.3390/jcm10030386.
Testo completoAbstract (sommario):
Gan-Lu-Yin (GLY), a traditional Chinese herbal medicine, shows therapeutic effects on periodontitis, but that mechanism is not well known. This study aims to clarify the precise mechanism by investigating the inhibitory effects of GLY extracts on osteoclastogenesis in vitro and on bone resorption in periodontitis in vivo. RAW264.7 cells are cultured with soluble receptor activator of nuclear factor-kappa B (sRANKL) and GLY extracts (0.01–1.0 mg/mL), and stained for tartrate-resistant acid phosphatase (TRAP) to evaluate osteoclast differentiation. Experimental periodontitis is induced by placing a nylon ligature around the second maxillary molar in rats, and rats are administered GLY extracts (60 mg/kg) daily for 20 days. Their maxillae are collected on day 4 and 20, and the levels of alveolar bone resorption and osteoclast differentiation are estimated using micro-computed tomography (CT) and histological analysis, respectively. In RAW264.7 cells, GLY extracts significantly inhibit sRANKL-induced osteoclast differentiation at a concentration of more than 0.05 mg/mL. In experimental periodontitis, administering GLY extracts significantly decreases the number of TRAP-positive osteoclasts in the alveolar bone on day 4, and significantly inhibits the ligature-induced bone resorption on day 20. These results show that GLY extracts suppress bone resorption by inhibiting osteoclast differentiation in experimental periodontitis, suggesting that GLY extracts are potentially useful for oral care in periodontitis.
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Alp, Hayriye. "Evaluation of anthropometric results after acupuncture and diet applications in obesity patients:an experimental-control study". Acupuncture & Electro-Therapeutics Research 45, n. 2 (8 febbraio 2021): 97–106. http://dx.doi.org/10.3727/036012921x16112663844905.
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Obesity is a disease defined by excessive fat storage in the body. It is an energy balance problem; the increase in body fat is caused by an imbalance between energy intake and energy expenditure. This study aimed to determinate the changes in the anthropometric measurements of patients after acupuncture treatment used in obesity treatment. The present study was a cross-sectional study conducted in 2019 in xxx University's GETAT Center). Patients aged between 18–65 years with a BMI > 25 were included in the study. The participants were divided into two groups: Group 1 (acupuncture and diet) and Group 2 (diet only). Exclusion criteria: Pregnant women, breastfeeding patients , susceptible demographics (acute coronary insufficiency, immunodeficiency, severe psychotic disorder, liver and kidney failure), and those who could not give consent were not included in the study. Weight, BMI, and metabolic age values were measured with a Tanita device; the same diagnostic device was used for all patients. Both body and ear acupuncture were performed. In patients with all acupuncture, the yuan points of abnormal meridians were used for pulse diagnosis. ST 24, 25, and 36 (ZuSanLi); GV 20, 21, 5, 5, and LR 3 (Taichong); SP 6 and 9, GB 34, UB 62, HT 7, LU 9, and PC 6 (Nei Guan); and SI 3 and EXT-HN 3 (Yin-Tang) points were dewed. For ear acupuncture, hunger, kidney, larynx, stomach, jerome, and shen-men points were taken. A t-test was applied to pre- and post-acupuncture measurement values. After acupuncture, the waist circumference of the participants decreased significantly (p < 0.005). The BMI of the participants also decreased significantly after acupuncture (p < 0.005). In these studies, LU 6, ST 40, ST 21, K 4, ST 36 and 25, and LI 11 body points were used, while hunger, stomach, and shen-men points were commonly used as ear points.
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Shikoski, Jovan, Rumen Arnaudov e Tinko Eftimov. "Photonic powering of sensors with bidirectional communication along a single fiber". Photonics Letters of Poland 12, n. 1 (31 marzo 2020): 7. http://dx.doi.org/10.4302/plp.v12i1.919.
Testo completoAbstract (sommario):
In this paper we propose and study simultaneous transmission of photonic power and bidirectional communication to and from sensors via 840/1310 nm WDMs. The photovoltaic converter is used both for power conversion and data transfer from the high power laser at 808nm up to 1Mb/s while the 1310nm link can be up to 155 Mb/s.Full Text: PDF References:J.C.V.da Silva, E.L.A.S.de Souza, V.Garcia, J.B.Rosolem, C.Floridia, M.A.B.Sanches, "Design of a Multimode Fiber Optic Cable to Transmit Optical Energy for Long Reach in PoF Systems", Proceedings of the 63rd IWCS Conference, International Wire & Cable Symposium, Shrewsbury, PA, USA, 2014, pp.832-839. [CrossRef]J.B. Rosolem, E.K.Tomiyama, D.C.Dini, F.R.Bassan, R.S.Penze, A.A.Leonardi, C. Floridia, J.P.Fracarolli, R.M.Teixeira, "A fiber optic powered sensor designed for partial discharges monitoring on high voltage bushings". Proc. of SBMO/IEEE MTT‐S International Microwave and Optoelectronics Conference (IMOC); 3-6 Nov. 2015; Porto de Galinhas, Brazil, pp. 1-5. [CrossRef]T.C. Banwell, R.C.Estes, L.A.Reith, P.W.Shumate, E.M.Vogel, "Powering the fiber loop optically - a cost analysis", IEEE J. of Lightwave Techn., Vol. 11, No. 3, pp. 481-494, 1993. [CrossRef]M. Dumke, G. Heiserich, S. Franke, L. Schulz, and L. Overmeyer, "Power Transmission by Optical Fibers for Component Inherent Communication", Systemics, Cybernetics And Informatics, Vol.8, No.1, pp. 55-60, (2010) [DirectLink]C. Gao, J. Wang, L. Yin, J. Yang, J. Jiang, H. Wan, Optically Powered Active Sensing System for Internet Of Things, Proc. SPIE 9270, Optoelectronic Devices and Integration V, 927016 (24 October 2014) [CrossRef]J. Yan, J. Wang, Y. Lu, J. Jiang, H. Wan, Novel Wireless Sensor System Based on Power-over-Fiber Technique, 14th Int. Conf. on Optical Comm. and Networks (ICOCN) 3-5 July 2015, Nanjing, China, 15382393 [CrossRef]Böttger, G.; Dreschmann, M.; Klamouris, C.; Hü bner, M.; Röger, M.; Bett, A. W.; Kueng, T.; Becker, J.; Freu de, W.; Leuthold, J.: An Otically Powered Video Camera Link. IEEE Photonics Technology Letters, Vol. 20, No. 1, pages 39-41, 2008. [CrossRef]M. Matsuura and J. Sato, Bidirectional Radio-Over-Fiber Systems Using Double-Clad Fibers for Optically Powered Remote Antenna Units, IEEE Photonics J., Vol. 7, No. 1, 2015, 7900609 [CrossRef]J. Wang, Q. Li, J. Yan, Y. Ding, Y. Lu, Y. Zhang, H. Wan, Power-Over-Fiber Technique based Sensing System for Internet оf Things, 15th International Conference on Optical Communications and Networks (ICOCN), Hangzhou, China, Sep. 24-27, 2016. [CrossRef]S. Kartalopoulos, Optical Bit Error Rate: An Estimation Methodology (2004) Willey- IEEE Press. [CrossRef]J. Shikoski, R. Arnaudov, and T. Eftimov, A study of the frequency characteristics of a photovoltaic convertor РРС-4Е, Photonics Letters of Poland, Vol. 10(3), (2018), pp. 70-72 [CrossRef]J. B. Rosolem, Optical Fiber and Wireless Communications, Ed. by R. Róka, Ch. 13, Power‐Over‐Fiber Applications for Telecommunications and for Electric Utilities, Intech Open Ltd, London, 2017, pp.255-278. [CrossRef]
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Dan'shin, Aleksandr. "Forensic Medical Expertise in Traditional China: Legal Regulation and Practice". Bulletin of Kemerovo State University. Series: Humanities and Social Sciences 2021, n. 4 (6 dicembre 2021): 348–57. http://dx.doi.org/10.21603/2542-1840-2021-5-4-348-357.
Testo completoAbstract (sommario):
The article deals with the problems of forensic medical expertise in traditional China in the investigation of crimes related to murder and death of people under unknown circumstances. The research featured legal acts and related comments that regulated the procedure. The author focused on the treatise of the XIII century Sung Tzu's "Washing Away of Wrongs" (Hsi yüan lu), which became the first essay on forensic medicine in world history. This document was far ahead of European works on this topic and was still in use in the early XX century. Constant conflicts between non-official comments and legal norms were one of the most serious problems that judicial practice had to face. For instance, according to the century-long shiht’u practice, specially authorized employees (wutso) with no medical training were responsible for describing internal and external injuries on the human body. Medical education was not mandatory for those performing forensic medical examination because autopsy was prohibited under the threat of punishment in the form of hard labor, and all conclusions about the causes of death were made on the basis of external examination. However, the main problem was the legal responsibility for the falsification of forensic medical examination. It often affected innocent people while real criminals managed to escape punishment, which violated the yin-yang harmony.
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Baley, Patricia. "Acupuncture and Chinese Herbal Therapy for Acute Upper Respiratory Disease in a Geriatric Quarter Horse". American Journal of Traditional Chinese Veterinary Medicine 4, n. 1 (1 febbraio 2009): 52–57. http://dx.doi.org/10.59565/edgh4562.
Testo completoAbstract (sommario):
A 32 year old emaciated rescued Quarter Horse gelding with a very depressed Shen was presented for a Traditional Chinese Veterinary Medical evaluation by a new caretaker. He had a 3 week history of clear nasal discharge which had not resolved with trimethoprim sulfa and enrofloxacin. His TCVM diagnosis was Kidney Jing (Essence) and global Kidney deficiency, causing a secondary Spleen Qi deficiency and Wei Qi deficiency. This had made him suspectible to Wind-Cold invasion. He was treated with acupuncture using dry needles at LU-1, LI-4, LI-20, ST-36, BL-20, BL-23, BL-24, KID-3, KID-7, Bai-hui GV-14 and Tong-tang and the Chinese herbal formula Wei Qi booster containing Huang Qi (Astragalus membranaceus) to tonify the Spleen and augment the Wei Qi. One month later he returned in much better physical condition with weight gain and improved Shen and respiratory signs. The nasal discharge had changed to yellow. A Wind-Heat invasion was then diagnosed and acupuncture was repeated and the Chinese herbal formula Equine Yin Qiao was prescribed for 2 weeks. By the end of this treatment period the horse had completely recovered and returned to work as a lesson horse to teach young children to ride. He was normal and required no further treatment for 18 months.
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Jhang, Jing-Siang, Hanoch Livneh, Shu-Yi Yang, Hui-Ju Huang, Michael W. Y. Chan, Ming-Chi Lu, Chia-Chou Yeh e Tzung-Yi Tsai. "Decreased risk of colorectal cancer among patients with type 2 diabetes receiving Chinese herbal medicine: a population-based cohort study". BMJ Open Diabetes Research & Care 8, n. 1 (marzo 2020): e000732. http://dx.doi.org/10.1136/bmjdrc-2019-000732.
Testo completoAbstract (sommario):
ObjectivesPatients with type 2 diabetes have a higher risk of colorectal cancer (CRC), but whether Chinese herbal medicines (CHMs) can reduce this risk is unknown. This study investigated the effect that CHMs have on CRC risk in patients with type 2 diabetes.Research design and methodsThis cohort study used the Taiwanese National Health Insurance Research Database to identify 54 744 patients, newly diagnosed with type 2 diabetes, aged 20–70 years, who were receiving treatment between 1998 and 2007. From this sample, we randomly selected 14 940 CHMs users and 14 940 non-CHMs users, using propensity scores matching. All were followed through 2012 to record CRC incidence. Cox proportional hazards regression was used to compute the hazard ratio (HR) of CRC by CHMs use.ResultsDuring follow-up, 235 CHMs users and 375 non-CHMs users developed CRC, incidence rates of 1.73% and 2.47% per 1000 person-years, respectively. CHM users had a significantly reduced risk of CRC compared with non-CHM users (adjusted HR=0.71; 95% CI 0.60 to 0.84). The greatest effect was in those receiving CHMs for more than 1 year. Huang-Qin, Xue-Fu-Zhu-Yu-Tang, Shu-Jing-Huo-Xue-Tang, Liu-Wei-Di-Huang-Wan, Ji-Sheng-Shen-Qi-Wan, Gan-Lu-Yin, Shao-Yao-Gan-Cao-Tang and Ban-Xia-Xie-Xin-Tang were significantly associated with lower risk of CRC.ConclusionIntegrating CHMs into the clinical management of patients with type 2 diabetes may be beneficial in reducing the risk of CRC.
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Bao, Wurigumula, e Ying Shirley Meng. "(Invited) Development and Application of Titration Gas Chromatography in Elucidating the Behavior of Anode in Lithium Batteries". ECS Meeting Abstracts MA2023-01, n. 2 (28 agosto 2023): 633. http://dx.doi.org/10.1149/ma2023-012633mtgabs.
Testo completoAbstract (sommario):
The accelerated transition to renewable energy systems worldwide has triggered increasing interest in energy storage technologies, especially in lithium batteries. Accurate diagnosis and understanding of the batteries degradation mechanism are essential. Titration Gas Chromatography (TGC) has been developed to quantitively understand the anode. The inactive Li in the cycled anode can be categorized into two kinds: 1) trapped Li0 (such as trapped lithiated graphite (LixC6), Li0, and lithium silicon alloy (LixSi)) and 2) solid electrolyte interphase (SEI) Li+. Noted that only trapped Li0 can react with the protic solvent to generate the hydrogen (H2), while SEI (Li+) does not1. Therefore, the H2 gas quantification can be correlated to the trapped Li0 as the foundation mechanism of TGC. With the optimal solvent selection, we successfully applied TGC to investigated: 1) the degradation behavior of Si-based anode materials2, 3; 2) corrosion effects on electrochemically deposited Li metal anode4; 3) the cycling behavior of Gr anode; 4) Li inventory quantification in practical Li metal battery5. We demonstrate the various application of TGC techniques in quantitatively examining the Li inventory changes of the anode. Beyond that, the results can provide unique insights into identifying the critical bottlenecks that facilitate battery performance development. References: Fang, C.; Li, J.; Zhang, M.; Zhang, Y.; Yang, F.; Lee, J. Z.; Lee, M. H.; Alvarado, J.; Schroeder, M. A.; Yang, Y.; Lu, B.; Williams, N.; Ceja, M.; Yang, L.; Cai, M.; Gu, J.; Xu, K.; Wang, X.; Meng, Y. S., Quantifying inactive lithium in lithium metal batteries. Nature 2019, 572 (7770), 511-515. Bao, W.; Fang, C.; Cheng, D.; Zhang, Y.; Lu, B.; Tan, D. H.; Shimizu, R.; Sreenarayanan, B.; Bai, S.; Li, W., Quantifying lithium loss in amorphous silicon thin-film anodes via titration-gas chromatography. Cell Reports Physical Science 2021, 2 (10), 100597. Sreenarayanan, B.; Tan, D. H.; Bai, S.; Li, W.; Bao, W.; Meng, Y. S., Quantification of lithium inventory loss in micro silicon anode via titration-gas chromatography. Journal of Power Sources 2022, 531, 231327. Lu, B.; Li, W.; Cheng, D.; Bhamwala, B.; Ceja, M.; Bao, W.; Fang, C.; Meng, Y. S., Suppressing chemical corrosions of lithium metal anodes. Advanced Energy Materials 2022, 2202012. Deng, W.; Yin, X.; Bao, W.; Zhou, X.; Hu, Z.; He, B.; Qiu, B.; Meng, Y. S.; Liu, Z., Quantification of reversible and irreversible lithium in practical lithium-metal batteries. Nature Energy 2022, 7 (11), 1031-1041.
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Li, Hsin-Hua, Hanoch Livneh, Wei-Jen Chen, Ming-Chi Lu, Wen-Yen Chiou, Shih-Kai Hung, Chia-Chou Yeh e Tzung-Yi Tsai. "Chinese Herbal Medicine to Reduce Radiation-Induced Oral Mucositis in Head and Neck Cancer Patients: Evidence From Population-Based Health Claims". Integrative Cancer Therapies 20 (gennaio 2021): 153473542110448. http://dx.doi.org/10.1177/15347354211044833.
Testo completoAbstract (sommario):
Background: Subjects with head and neck cancer (HNC) often experience post-treatment side effects, particularly radiation-induced oral mucositis (RIOM). This study aimed to explore the association of Chinese herbal medicine use with the sequent risk of RIOM among them. Methods: This cohort study used a nationwide health insurance database to identify subjects newly diagnosed with HNC, aged 20 to 60 years, who received treatment between 2000 and 2007. Among them, a total of 561 cases received CHM after HNC onset (CHM users); the remaining 2395 cases were non-CHM users. All patients were followed to the end of 2012 to identify any treatment for RIOM as the end point. Cox proportional hazards regression was used to compute the adjusted hazard ratio (aHR) of RIOM by CHM use. Results: During the follow-up period, 183 CHM users and 989 non-CHM users developed RIOM at incidence rates of 40.98 and 57.91 per 1000 person-years, respectively. CHM users had a lower RIOM risk than the non-CHM users (aHR: 0.68; 95% Confidence Interval: 0.58-0.80). The most potent effect was observed in those taking CHM for more than 1 year. Use of Baizhi, Danshen, Shao-Yao-Gan-Cao-Tang, Gan-Lu-Yin, Huangqin, Shu-Jing-Huo-Xue-Tang, and Xin-Yi-Qing-Fei-Tang, was significantly related to a lower risk of RIOM. Conclusion: Findings of this study indicated that adding CHM to conventional clinical care could be helpful in protecting those with HNC against the onset of RIOM. Further clinical and mechanistic studies are warranted.
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Artiushin, S., J. F. Timoney, J. Nally e A. Verma. "Host-Inducible Immunogenic Sphingomyelinase-Like Protein, Lk73.5, of Leptospira interrogans". Infection and Immunity 72, n. 2 (febbraio 2004): 742–49. http://dx.doi.org/10.1128/iai.72.2.742-749.2004.
Testo completoAbstract (sommario):
ABSTRACT Leptospira interrogans causes a variety of clinical syndromes in animals and humans. Although much information has accumulated on the importance of leptospiral lipopolysaccharide in protective antibody responses, relatively little is known about proteins that participate in immune responses. Identification of those proteins induced only in the host is particularly difficult. Using a novel double-antibody screen designed to identify clones in a gene library of L. interrogans serovar Pomona expressing host-inducible proteins, we have characterized a gene (lk75.3) encoding a sphingomyelinase-like preprotein of 648 amino acids with cytotoxic activity for equine pulmonary endothelial cells and weak hemolytic activity for equine and rabbit erythrocytes. lk73.5 was found as a single gene copy in all serovars of L. interrogans but not in other Leptospira spp. except L. inadai. The open reading frame (ORF) for Lk73.5 is followed by another partially homologous sequence containing an ORF (sph-like 2) for a 28.7-kDa peptide. Lk73.5 and Sph-like 2 share 95.1 and 97.7% amino acid identity with putative sphingomyelinases Sph2 and Sph1 (N terminus) from L. interrogans serovar Lai (S.-X. Ren, G. Fu, X.-G. Jiangk, R. Zeng, Y.-G. Miao, H. Xu, Y.-X. Zhang, H. Xiong, G. Lu, L.-F. Lu, H.-Q. Jiang, J. Jia, Y.-F. Tu, J.-X. Jiang, W.-Y. Gu, Y.-Q. Zhang, Z. Cai, H.-H. Sheng, H.-F. Yin, Y. Zhang, G.-F. Zhu, M. Wank, H.-L. Huangk, Z. Qian, S.-Y. Wang, Wei Ma, Z.-J. Yao, Y. Shen, B.-Q. Qiang, Q.-C. Xia, X.-K. Guo, A. Danchinq, I. S. Girons, R. L. Somerville, Y.-M. Wen, M.-H. Shik, Z. Chen, J.-G. Xuk, and G.-P. Zhao, Nature 422:88-893, 2003). Substantial homologies to sphingomyelinases from other leptospiras and other bacteria are also present. Lk73.5 was not detected in leptospiras cultured at 30 or 37°C. The recombinant protein reacted strongly with sera from recently infected mares but not with sera from horses vaccinated with commercial pentavalent bacterin. The host-inducible immunogenic Lk73.5 should have value in distinguishing vaccine from infection immune response.
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Yan, Q., B. Liu, J. Wang, H. Yin, Q. Li e L. Lu. "POS1267 IGURATIMOD AS AN ALTERNATIVE THERAPY FOR SYSTEMIC SCLEROSIS AND PREVENTION OF ISCHEMIC DIGITAL ULCER OCCURRENCE". Annals of the Rheumatic Diseases 82, Suppl 1 (30 maggio 2023): 977.2–977. http://dx.doi.org/10.1136/annrheumdis-2023-eular.930.
Testo completoAbstract (sommario):
BackgroundSystemic sclerosis (SSc) is not only one of the autoimmune diseases with the highest mortality but rises a severe disease burden through some not directly lethal but suffering complications such as digital ulcers (DU) [1].Iguratimod(IGU) is typically thought of as an anti-inflammatory and immunoregulatory drug [2]. On top of anti-inflammation, IGU has shown potential efficacy on fibrotic complications with autoimmune diseases[3].ObjectivesTo assess the effectiveness of IGU as an alternative treatment for SSc, especially in the prevention of ischemic DU.MethodsWe constructed two cohorts from the Renji SSc registry. In the first cohort, SSc patients receiving IGU were observed prospectively with effectiveness and safety. In the second cohort, we picked up all the DU patients with at least a 3-month follow-up to investigate the prevention of IGU on ischemic DU.Results1) IGU was a plausible alternative treatment for SSc with acceptable tolerance. 91.3% (21/23) of the SSc patients were disease worsening-free during IGU treatment (median follow-up: 61 weeks). 2) We unexpectedly discovered that IGU was protective against ischemic DU. Although with a limited patient number, 72.7% (8/11) of IGU-treated patients had no new DU occurrence in a median follow-up of 39 weeks; further in the second DU cohort (Table1), the protection of IGU was still true for new DU occurrence (adjusted RR = 0.25, 95% CI, 0.05-0.94, adjusted OR = 0.07, 95% CI, 0.01-0.49)(Figure 1).ConclusionOur study indicates IGU as a possible alternative treatment for SSc. Beyond expectation, this study for the first time describes IGU as preventative against ischemic DU occurrence and merits further investigation.References[1]Zelenietz C et al. Ann Rheum Dis. 2010;69(11):2055-6.[2]Jiang H et al. Biomedicine & Pharmacotherapy. 2020;122:109704.[3]Yan Q et al. Ann Rheum Dis. 2019;78(Suppl 2):459.Table 1Baseline Characteristics of the Study Participants with Digital Ulcers.CharacteristicsWith IGU (N=11)Without IGU (N=20)P valueAge of Onset(years), median (IQR)36.0(31.0-53.0)43.0(34.0-54.0)0.457Sex(%)MaleFemale2(18.2)9(81.8)6(30.0)14(70.0)0.676Time since RP onset (years), median(IQR)9.0(3.0-12.0)7.5(3.0-14.8)0.740Time since first non-RP manifestation (years), median (IQR)9.0(2.0-11.0)5.5(2.3-12.8)0.634SSc subtype(%)DiffuseLimitedSine scleroderma9(81.8)2(18.2)010(50.0）8(40.0)2(10.0)0.133ESR(mm/h), median (IQR)29.0(15.5-53.8)27.0(13.5-47)0.880Autoantibodies(%)Anti-Scl70 antibody positiveACA positiveAnti-U1RNP positiveAnti-Th/To positive6(60.0)1(10.0)3(30.0)012(75.0)2(12.5)1(6.3)1(6.3)0.332Smoke(>25 pack-years)(%)04(20.0)0.269Previous DU(s)4(36.4)8(40.0)1.0Vasodilator use (at least one agent) (%)PDE5iERACCBBeraprost11(100)6(54.5)5(45.5)4(36.4)5(45.5)20(100)14(70.0)5(25.0)6(30.0)11(55.0)0.4520.42310.716Pulmonary hypertension(%)3(27.3)6(30.0)1ILD(%)9(81.8)13(65.0)0.429DU new occurrence during follow-up(%)nevernew occurrence8(72.7)3(27.3)5(25.0)15(75.0)0.021Figure 1.Forest plot displaying the association of the outcome (occurrence of ischemic DUs) with IGU treatment.Authors’ detailsQingran Yan1, Bei Liu1, Jieying Wang2, Hanlin Yin1, Qianqian Li1, and Liangjing Lu11Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.2 Clinical Center for Investigation, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.AcknowledgmentsThis work was supported by the National Natural Science Foundation of China (81974251) and Shanghai Municipal Commission of Health and Family Planning (20204Y0088).Abstract number435Declaration of conflict of interestQingran Yan: None declared, Bei Liu: None declared, Jieying Wang: None declared, Hanlin Yin: None declared, Qianqian Li: None declared, and Liangjing Lu: None declared.AcknowledgementsThis work was supported by the National Natural Science Foundation of China (81974251) and Shanghai Municipal Commission of Health and Family Planning (20204Y0088).Disclosure of InterestsNone Declared.
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Li, Haoyan, Yin Wang, Kevin Lin, Varadha Balaji Venkadakrishnan, Martin Bakht, Kaitlyn Tremble, Yue Lu, Himisha Beltran e Di Zhao. "Abstract B022: CHD1 promotes sensitivity to aurora kinase inhibitors by modulating the interaction of AURKA with TPX2". Cancer Research 82, n. 23_Supplement_2 (1 dicembre 2022): B022. http://dx.doi.org/10.1158/1538-7445.cancepi22-b022.
Testo completoAbstract (sommario):
Abstract Clinical studies have shown that subsets of cancer patients achieve a significant benefit from Aurora kinase inhibitors, suggesting an urgent need to identify biomarkers for predicting drug response. Chromodomain-helicase-DNA-binding protein 1 (CHD1) is involved in chromatin remodeling, DNA repair, and transcriptional plasticity. Prior studies have demonstrated that CHD1 has distinct expression patterns in cancers with different molecular features, but its impact on drug responsiveness remains understudied. Here, we show that CHD1 promotes the susceptibility of prostate cancer cells to inhibitors targeting Aurora kinases, while depletion of CHD1 impairs their efficacy in vitro and in vivo. Pan-cancer drug sensitivity analyses revealed that high expression of CHD1 was associated with increased sensitivity to Aurora kinase A (AURKA) inhibitors. Mechanistically, KPNA2 served as a direct target of CHD1 and suppressed the interaction of AURKA with the co-activator TPX2, thereby rendering cancer cells more vulnerable to AURKA inhibitors. Consistent with previous research reporting that loss of PTEN elevates CHD1 levels, studies in a genetically engineered mouse model, patient-derived organoids, and patient samples showed that PTEN defects are associated with a better response to AURKA inhibition in advanced prostate cancer. These observations demonstrate that CHD1 plays an important role in modulating Aurora kinases and drug sensitivities, providing new insights into biomarker-driven therapies targeting Aurora kinases for future clinical studies. Citation Format: Haoyan Li, Yin Wang, Kevin Lin, Varadha Balaji Venkadakrishnan, Martin Bakht, Kaitlyn Tremble, Yue Lu, Himisha Beltran, Di Zhao. CHD1 promotes sensitivity to aurora kinase inhibitors by modulating the interaction of AURKA with TPX2. [abstract]. In: Proceedings of the AACR Special Conference: Cancer Epigenomics; 2022 Oct 6-8; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2022;82(23 Suppl_2):Abstract nr B022.
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Hu, Yumin, Feng Yin, Mingyue Zhao, Wenhua Lu e Tiantian Yu. "Abstract 429: A novel regulatory role of FLT3/ITD mutation in lipid metabolism of leukemia cells: The mechanism and therapeutic implications". Cancer Research 84, n. 6_Supplement (22 marzo 2024): 429. http://dx.doi.org/10.1158/1538-7445.am2024-429.
Testo completoAbstract (sommario):
Abstract Internal tandem duplication in FMS-like tyrosine kinase 3 (FLT3/ITD), is a common type of activating mutation and frequently detected in AML. FLT3/ITD is associated with poor prognosis of AML. In this study, we investigated the regulation of FLT3/ITD mutation on sterol regulatory element-binding protein (SREBP) and the therapeutic vulnerabilities of lipid metabolism in FLT3/ITD leukemia. With the transcriptomics analysis we found that FLT3/ITD controlled lipid metabolism via the transcription factor SREBP. The analysis of TCGA_LAML dataset revealed that a gene signature involved in fatty acid and cholesterol metabolism, which is regulated by SREBP, was upregulated in FLT3/ITD patients compared with FLT3/wild-type patients. The upregulation of SREBP protein expression in FLT3/ITD leukemia was confirmed using a genetically engineered mouse model. We further demonstrated that FLT3/ITD regulates the protein degradation of SREBP through the PI3K/AKT-GSK3β axis. The metabolomics analysis further showed that FLT3/ITD primarily regulates glycerophospholipid synthesis, which contribute to the key structure lipid in the membrane, specifically, the cardiolipin. Moreover, pharmacologic inhibition of SREBP activation and its downstream enzyme fatty acid synthase (FASN) sensitized FLT3-ITD AMLs to the treatment of FLT3 inhibitor quizartinib. Collectively, our findings reveal a novel regulation of FLT3-ITD in metabolic reprogramming and indicate a targetable vulnerability in a subset of refractory leukemia. Citation Format: Yumin Hu, Feng Yin, Mingyue Zhao, Wenhua Lu, Tiantian Yu. A novel regulatory role of FLT3/ITD mutation in lipid metabolism of leukemia cells: The mechanism and therapeutic implications [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 429.
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Xu, Chang, Kie Kyon Huang, Jia Hao Law, Joy Shijia Chua, Taotao Sheng, Natasha M. Flores, Melissa Pool Pizzi et al. "Abstract P28: Comprehensive Molecular Phenotyping of ARID1A-deficient Gastric Cancer Reveals Pervasive Epigenomic Reprogramming and Therapeutic Opportunities". Cancer Research 84, n. 8_Supplement (15 aprile 2024): P28. http://dx.doi.org/10.1158/1538-7445.fcs2023-p28.
Testo completoAbstract (sommario):
Abstract Objective Gastric cancer (GC) is a leading cause of cancer mortality, with ARID1A being the second most frequently mutated driver gene in GC. We sought to decipher ARID1A-specific GC regulatory networks and examine therapeutic vulnerabilities arising from ARID1A loss. Design Genomic profiling of GC patients including a Singapore cohort (>200 patients) was performed to derive mutational signatures of ARID1A inactivation across molecular subtypes. Single-cell transcriptomic profiles of ARID1A-mutated GCs were analyzed to examine tumor microenvironmental changes arising from ARID1A loss. Genome-wide ARID1A binding and chromatin profiles (H3K27ac, H3K4me3, H3K4me1, ATAC-seq) of gastric cell lines were generated to identify gastric-specific epigenetic landscapes regulated by ARID1A. Distinct cancer hallmarks of ARID1A-mutated GCs were converged at the genomic, single-cell, and epigenomic level, and targeted by pharmacological inhibition. Results We observed prevalent ARID1A inactivation across GC molecular subtypes, with distinct mutational signatures and linked to a NFKB-driven pro-inflammatory tumour microenvironment. ARID1A-depletion caused loss of H3K27ac activation signals at ARID1A-occupied distal enhancers, but unexpectedly gain of H3K27ac at ARID1A-occupied promoters in genes such as NFKB1 and NFKB2. Promoter activation in ARID1A-mutated GCs was associated with enhanced gene expression, increased BRD4 binding, and reduced HDAC1 and CTCF occupancy. Combined targeting of promoter activation and tumour inflammation via bromodomain and NFKB inhibitors confirmed therapeutic synergy specific to ARID1A-genomic status. Conclusion Our results suggest a therapeutic strategy for ARID1A-mutated GCs targeting both tumour-intrinsic (BRD4-assocatiated promoter activation) and extrinsic (NFKB immunomodulation) cancer phenotypes. Citation Format: Chang Xu, Kie Kyon Huang, Jia Hao Law, Joy Shijia Chua, Taotao Sheng, Natasha M. Flores, Melissa Pool Pizzi, Atsushi Okabe, Angie Lay Keng Tan, Feng Zhu, Vikrant Kumar, Xiaoyin Lu, Ana Morales Benitez, Benedict Shi Xiang Lian, Haoran Ma, Shamaine Wei Ting Ho, Kalpana Ramnarayanan, Chukwuemeka George Anene-Nzelu, Milad Razavi-Mohseni, Siti Aishah Binte Abdul Ghani, Su Ting Tay, Xuewen Ong, Ming Hui Lee, Yu Amanda Guo, Hassan Ashktorab, Duane Smoot, Shang Li, Anders Jacobsen Skanderup, Michael A. Beer, Roger Sik Yin Foo, Joel Shi Hao Wong, Kaushal Sanghvi, Wei Peng Yong, Raghav Sundar, Atsushi Kaneda, Shyam Prabhakar, Pawel Karol Mazur, Jaffer A. Ajani, Khay Guan Yeoh, Jimmy Bok-Yan So, Patrick Tan, Singapore Gastric Cancer Consortium. Comprehensive Molecular Phenotyping of ARID1A-deficient Gastric Cancer Reveals Pervasive Epigenomic Reprogramming and Therapeutic Opportunities [abstract]. In: Proceedings of Frontiers in Cancer Science; 2023 Nov 6-8; Singapore. Philadelphia (PA): AACR; Cancer Res 2024;84(8_Suppl):Abstract nr P28.
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Guest, Luise. "Gendered bodies: Feminism and Chineseness in the work of Li Xinmo, Xiao Lu and Xie Rong". Journal of Contemporary Chinese Art 10, n. 1 (1 agosto 2023): 85–106. http://dx.doi.org/10.1386/jcca_00077_1.
Testo completoAbstract (sommario):
From its emergence in the post-Mao era of gaige kaifang (Reform and Opening) the performing body in Chinese xingwei yishu (‘performance art’) was most often assumed to be male. The representation of performance practices in exhibitions, festivals – and in the art historical literature – has too often been dominated by male artists. This article turns the gaze onto three women artists, examining their work through lenses of gender, feminism and ‘Chineseness’: Performance artists Xiao Lu (b. 1962), Li Xinmo (b. 1976) and Xie Rong (b. 1983) explore aspects of embodied lived experience in often-encoded ways. Li Xinmo explores experiences of gendered violence through theatrical, immersive performances that have often used ink or pigmented fluids as metaphors for blood and trauma – and through a series of paintings made with actual menstrual blood. In The Death of the Xinkai River (2007) she first explicitly links an embodied feminism with her distress at the destruction of the natural environment. Xiao Lu’s post-menopausal performances move beyond her previously more literal explorations of gender. Works such as Ren (2016) and Suspension () employ ink and water in poetic reference to shufa (‘calligraphy’) and shuimo hua (‘ink-wash painting’). Inserting herself into the visual language of literati scholar painters, an artistic lineage from which she would have been excluded by virtue of her gender, Xiao’s liquid materiality becomes a feminist embodiment. Xie Rong (also known until recently by her English name, Echo Morgan) ‘writes’ ink painting using her hair as her brush in I Am a Brush (2011), Painting Until it Becomes Marble (2019) and Anatomy of . She paints her naked body with images of birds and flowers and blue-and-white porcelain motifs to perform lamentations of grief, loss and longing in works such as Be The Inside of the Vase (2012) and Echo of Posidonia (2022). Framed by Anne Anlin Cheng’s concept of ‘ornamentalism’, Ella Shohat’s notion of a non-western ‘subterranean’ feminism and early twentieth-century anarcho-feminist He-Yin Zhen’s gendering category of nannü, the artists’ embodied practices are understood as creating nannü spaces that reveal female subjectivities and reposition them within the discourses of Chinese performance practice. Emerging from encounters with the artists, in studio visits and (during the pandemic years) online conversations, analysis of their counter-patriarchal work reveals not merely the ghostly presences and absences of women in narratives of performance art in China that have tended to marginalize them, but also the significance of their contributions.
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Yang, Jai-Sing, Chia-Chun Wu, Hong-Zin Lee, Wen-Tsong Hsieh, Feng-Yao Tang, Da-Tian Bau, Kuang-Chi Lai, Jin-Cherng Lien e Jing-Gung Chung. "Suppression of the TNF-alpha level is mediated by Gan-Lu-Yin (traditional Chinese medicine) in human oral cancer cells through the NF-kappa B, AKT, and ERK-dependent pathways". Environmental Toxicology 31, n. 10 (26 febbraio 2015): 1196–205. http://dx.doi.org/10.1002/tox.22127.
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Pulido, Ines, Qiyue Luan, Chenghao Yin, Zimo Yang, Jinhua Lin, Yaya Wang, Yuetong Sun et al. "Abstract B093: Treating KRAS(G12D) inhibitor resistance using a KRAS- and HSP90 chaperone-targeted hetero-bispecific small molecule agent". Molecular Cancer Therapeutics 22, n. 12_Supplement (1 dicembre 2023): B093. http://dx.doi.org/10.1158/1535-7163.targ-23-b093.
Testo completoAbstract (sommario):
Abstract KRAS is the most frequently mutated oncoprotein in human cancers. Although long considered “undruggable”, recent breakthroughs in medicinal chemistry have led to FDA-approval of the KRAS(G12C) mutation-specific inhibitors sotorasib and adagrasib for the treatment of KRAS(G12C)-positive non-small cell lung cancer. However, illustrating the need to develop additional novel agents targeting mutated KRAS, the 5-year relative survival rate for pancreatic cancer, which is commonly associated with a variety of different KRAS mutations, is only 12% (all SEER stages) due to poor early detection and a lack of effective treatments. In particular, KRAS(G12D) is the most common KRAS mutation, being found in 37% of pancreatic ductal adenocarcinomas (PDACs), as well as in 12.5% of colorectal cancer and 4.9% of lung adenocarcinoma (LUAD) patients. MRTX1133 is a highly-selective, non-covalent KRAS(G12D) inhibitor that has recently entered a phase 1 clinical trial. However, here we show that exposure of KRAS(G12D)-mutated PDAC (PANC-1 and AsPC-1) and LUAD (SK-LU-1) cell lines and a patient-derived organoid (PDO) PDAC model (RPAN001) to MRTX1133 resulted in varying degrees of in vitro efficacy. Decreased downstream KRAS signaling in the form of reduced phospho-ERK1/2 levels was observed to rapidly recover within 24 hours of treatment with 500 nM MRTX1133. Moreover, this rebound coincided with increased expression of KRAS, NRAS andHRAS mRNAs. Concurrently, activation of the receptor tyrosine kinases (RTKs) EGFR and MET was observed in PANC-1 and SK-LU-1 cells that displayed innate resistance to MRTX1133, while the sensitive AsPC-1 cells showed no such RTK activation. These results suggest that targeting of both KRAS(G12D) and RTKs may be needed to treat KRAS(G12D) inhibitor-resistant cancers. To address this, we employed a novel hetero-bispecific CHAMP molecule, RNK08179, that simultaneously targets both KRAS(G12D) and HSP90, an RTK-regulating chaperone protein. RNK08179 treatment demonstrated a striking reduction in phospho-ERK1/2 levels, RTK activation and cell viability in MRTX1133-resistant PANC-1 and SK-LU-1 cells. Furthermore, similar efficacy was observed in the MRTX1133-resistant RPAN001 PDO model. In summary, RNK08179 displayed promising efficacy in cancer models harboring KRAS(G12D) by suppressing both mutated KRAS and HSP90-supported RTK signaling. Citation Format: Ines Pulido, Qiyue Luan, Chenghao Yin, Zimo Yang, Jinhua Lin, Yaya Wang, Yuetong Sun, Chuche Liu, Haoxin Zhou, Marek Massad, Ian Papautsky, Thomas L. Prince, Guoqiang Wang, Kevin P. Foley, Weiwen Ying, Takeshi Shimamura. Treating KRAS(G12D) inhibitor resistance using a KRAS- and HSP90 chaperone-targeted hetero-bispecific small molecule agent [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2023 Oct 11-15; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2023;22(12 Suppl):Abstract nr B093.
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YUAN, Yidan. "The continuation of Confucianism and the transformation of culture: Zhang Zhidong’s literati circle in modern academic history, by LU Yin, Beijing, Peking University Press, 2015, 402 pp., ISBN 978-7-301-24150-9". Journal of Modern Chinese History 10, n. 2 (2 luglio 2016): 277. http://dx.doi.org/10.1080/17535654.2016.1237488.
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Dignam, James J., e Vanja M. Dukic. "Comments on: Yin W, Di G, Zhou L, Lu J, Liu G, Wu J, Shen K, Han Q, Shen Z, Shao Z. Time-varying pattern of recurrence risk for Chinese breast cancer patients". Breast Cancer Research and Treatment 116, n. 1 (21 giugno 2008): 209–10. http://dx.doi.org/10.1007/s10549-008-0092-4.
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Yin, Limei, Wenbo Wang, Zhuoran Yao, Jianxin Xue, Ruizhan Tong, Hui Wang, Shuangsi Liao et al. "Abstract 5569: CAR-T cells with αPDL1/CD28 switch-receptor synergize radiotherapy and anti-PD1 therapy in solid tumors". Cancer Research 82, n. 12_Supplement (15 giugno 2022): 5569. http://dx.doi.org/10.1158/1538-7445.am2022-5569.
Testo completoAbstract (sommario):
Abstract The therapeutic efficacy of CAR-T cells in solid tumors, unlike in hematologic tumor, is greatly limited by the insufficient infiltration and persistence of CAR-T cells as well as the immunosuppressive tumor microenvironment. The aim of this study was to overcome these obstacles by introducing an αPDL1/CD28 switch-receptor construct and by seeking combinatorial strategies for CAR-T cells in solid tumors. We found that in non-transduction T cells, the cytokine release and T cell proliferation were repressed in response to PD-L1 protein, while T cells that express αPDL1/CD28 switch-receptor showed enhanced functions, indicating that αPDL1/CD28 could revert PD-L1 inhibition into CD28 costimulation. CAR-T cells with αPDL1/CD28 switch-receptor showed better effector function than that of unitary CAR-T in vitro studies and significant responses in tumor-bearing mice, with more effector memory T cells infiltrated in the tumor. On this basis, PD-1 inhibitor can further enhance the efficacy and persistence of αPDL1/CD28 CAR-T cells, especially in PDL1+ tumor models. We found in vitro studies that radiotherapy increased the expression of T-cell recruiting chemokines and promoted CAR-T cell transmigration. In tumor-bearing mice, synergistic anti-tumor efficacy of mice treated with radiotherapy and αPDL1/CD28 CAR-T cells was further observed. Finally, triple therapy with radiotherapy and anti-PD1 plus αPDL1/CD28 CAR-T cells maximized antitumor responses and induced complete cures in the tumor-bearing mice. Our study suggests that αPDL1/CD28 augments the function of CAR-T cells, and the combinatorial regime of αPDL1/CD28 CAR-T cells, radiotherapy and anti-PD1 in solid tumors could be further investigated. Citation Format: Limei Yin, Wenbo Wang, Zhuoran Yao, Jianxin Xue, Ruizhan Tong, Hui Wang, Shuangsi Liao, Laduona Wang, Yue Zheng, Feifei Na, Min Yu, Xuanwei Zhang, Youling Gong, Meijuan Huang, Xianming Mo, Chong Chen, You Lu. CAR-T cells with αPDL1/CD28 switch-receptor synergize radiotherapy and anti-PD1 therapy in solid tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5569.
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Tertulien, Tamar, Ellen J. Kim, Wenyue Lu, Steven Zhu, Nathaly Rubio-Torio, Evelyn González, Marilyn A. Fraser et al. "Abstract C069: Reducing liver cancer risk through dietary change: Positive results from a community-based educational initiative in three racial/ethnic groups". Cancer Epidemiology, Biomarkers & Prevention 32, n. 1_Supplement (1 gennaio 2023): C069. http://dx.doi.org/10.1158/1538-7755.disp22-c069.
Testo completoAbstract (sommario):
Abstract Background: The existing body of literature suggests that modifiable lifestyle behaviors such as alcohol consumption and dietary behaviors were linked to viral hepatitis B/C and liver cancer. So far, most of the liver cancer awareness campaigns and behavioral interventions have focused on preventive behaviors such as screening, vaccination, and early diagnosis. Not enough efforts have been made to raise awareness of behavioral mechanism of liver cancer prevention, especially in the medically underserved populations. Methods: We used the community-based participatory research (CBPR) approach to implement an education initiative regarding the promotion of liver cancer among the African, Asian, and Hispanic populations within the Philadelphia metropolitan area and New York City. In this study, we used data from the pre-education surveys and follow-up assessments at 6 months post-education to assess the changes in dietary behaviors and alcohol consumption among participants. Results: The study sample includes 344 participants recruited through community-based organizations. The sample consists of 31 African Americans, 174 Asian Americans, and 139 Hispanic Americans. Among the African Americans participants, the consumption of scores such as fruits (2.710 to 3.581) and poultry (2.613 to 3.677) increased significantly, while vegetables and red meats decreased. In Asian Americans, the consumption of non-refined cereals (3.362 to 4.282), red meats (2.655 to 3.195), and dairy (2.851 to 3.701) products decreased. Lastly, among the Hispanic American participants poultry (2.173 to 3.554), dairy products (2.101 to 3.863), and olive oil (3.022 to 3.849) increased, as well as the consumption of alcohol. Conclusion: This community-based educational imitative generated different impacts in the three populations, further highlighting the needs for more targeted, culturally tailored efforts in health promotion among these underprivileged communities. Citation Format: Tamar Tertulien, Ellen J. Kim, Wenyue Lu, Steven Zhu, Nathaly Rubio-Torio, Evelyn González, Marilyn A. Fraser, Ming-Chin Yeh, Lin Zhu, Grace X. Ma, Olorunseun O. Ogunwobi, Yin Tan. Reducing liver cancer risk through dietary change: Positive results from a community-based educational initiative in three racial/ethnic groups [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr C069.
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Liu, Na, Hong Qing Liang, Sebastian Wohlrab e Robert Francke. "A Molecular Copper Catalyst for Electrochemical Conversion of CO2 to C2+ Products". ECS Meeting Abstracts MA2023-02, n. 52 (22 dicembre 2023): 2486. http://dx.doi.org/10.1149/ma2023-02522486mtgabs.
Testo completoAbstract (sommario):
Electrochemical carbon dioxide reduction (CO2RR) is a promising route to address the excessive emission of CO2 and the depletion of fossil fuels.[1] Metallic Cu and Cu-based materials have attracted increased attention, as Cu is the only metal that can reliably convert CO2 into hydrocarbons and oxygenates, such as ethanol, ethylene, and n-propanol.[2] To optimize CO2-to-C2+ conversion, considerable efforts were made to modify the catalyst composition and structure, adjusting the electrolyte, and optimizing the electrochemical setup.[3] In this context, molecular catalysts (i.e. transition metal complexes) are interesting alternatives, since the performance can be precisely tuned via ligand modification and due to the possibility for mechanistic studies at well-defined and uniform active sites.[4] Herein, a catalytic system based on an immobilized dinuclear Cu phenanthroline complex is reported that can be prepared with a straightforward synthetic method. The catalyst exhibits excellent CO2RR selectivity toward C-C coupling in aqueous electrolytes with only small production of H2. The highest Faradaic efficiency (FE) for C2+ products achieved was 62% at -1.85 V vs. Ag/AgCl with less than 10% FE for H2. Furthermore, a steady current density and a stable FE(C2H4) over 10 h continuous operation indicate a good stability of the Cu complex. In this contribution, both the electrolysis results and the relationship between structural aspects and product selectivity will be discussed, the latter based on scanning/transmission electron microscopy, X-ray photoelectron/absorption spectroscopy, and further analytical techniques. Literature: [1] X. Su, Z. Jiang, J. Zhou, H. Liu, D. Zhou, H. Shang, X. Ni, Z. Peng, F. Yang, W. Chen, Z. Qi, D. Wang, Y. Wang, Nat. Commun. 2022, 13, 1322. [2] W. Quan, Y. Lin, Y. Luo, Y. Huang, Adv. Sci. 2021, 8, e2101597. [3] J. Yu, J. Wang, Y. Ma, J. Zhou, Y. Wang, P. Lu, J. Yin, R. Ye, Z. Zhu, Z. Fan, Adv. Funct. Mater. 2021, 31. [4] D. H. Nam, P. De Luna, A. Rosas-Hernandez, A. Thevenon, F. Li, T. Agapie, J. C. Peters, O. Shekhah, M. Eddaoudi, E. H. Sargent, Nat. Mater. 2020, 19, 266.
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Liu, Yen-Lin, Yin-Ju Chen, Shu-Huey Chen, Yu-Mei Liao, Wu Shih-Pei, Yi-Hsuan Chen, Wan-Ling Ho et al. "Abstract 6723: Application of in vitro drug screening of circulating tumor cells in pediatric glioma therapy". Cancer Research 83, n. 7_Supplement (4 aprile 2023): 6723. http://dx.doi.org/10.1158/1538-7445.am2023-6723.
Testo completoAbstract (sommario):
Abstract Twenty-one gliomas in patients aged 0-21 years were evaluated for drug sensitivity by ex vivo expanded circulating tumor cells (CTC). The results were correlated with clinical outcomes. Venous blood samples were obtained prior to drug treatment. Peripheral blood mononuclear cells were processed in a 3D cell culture system (EVA Select™, Cancer Free Biotech Ltd., Taipei, Taiwan) and cultured for 3 weeks. Expanded CTCs were successfully cultured into organoids from 18 out of 21 patients and were analyzed for ATP abundance. Staining with CD45, a marker for blood cells, and pancytokeratin, a marker for keratinocytes, was performed on the cultured cells. Staining of GFAP, a marker of glioma cells, was performed in a subset of samples. These cells were then tested in cytotoxicity assays in triplicate with a panel of chemotherapeutic and targeted agents at clinically relevant concentrations. The surviving fraction was normalized to a buffer-only control. Based on the percentage of cell viability, the agent was chosen for clinical treatment. Comparing the results among low-grade glioma (LGG; n = 6), diffuse midline glioma (DMG; n = 4), and high-grade glioma (HGG, n = 8; including glioblastoma multiforme [GBM; n = 5]), the mean surviving fraction to temozolomide was similarly high across the three tumor types (LGG vs. DMG vs. HGG = 57.5% vs. 50.6% vs. 49.5%, respectively). 6 of 6 patients in the LGG group showed CTC sensitivity to at least one chemotherapeutic agent tested. The clinical response of patients treated with selected agents was evaluated with the RANO criteria at 6 months after initiation of treatment. Among the 24 agents tested with clinical correlation, the CTC surviving fraction after exposure to the agent was significantly higher in patients who had progressive disease within 6 months (n = 11; 68%) vs. in patients with no progression at 6 months (n = 13; 39%; P = 0.039). Treating CTCs with histone deacetylase inhibitors in vitro resulted in a consistently lower surviving fraction (15.1% ± 12.0%) for DMG and HGG/GBM; however, clinical correlation was not available. The 1 patient with clinical correlation with HGG had a 34.9% surviving fraction to a Tyrosine kinase inhibitor (TKI) in vitro and showed a 42.9% shrinkage at 6 months after treatment with the TKI. The expansion of CTCs in patients with relapsed/refractory pediatric gliomas provides the ability to test drug sensitivity of patient-derived organoids. Our data suggest a correlation between the ex vivo drug sensitivity of CTCs and clinical response. Citation Format: Yen-Lin Liu, Yin-Ju Chen, Shu-Huey Chen, Yu-Mei Liao, Wu Shih-Pei, Yi-Hsuan Chen, Wan-Ling Ho, Liang-Yi Juo, Chia-Yau Chang, Jinn-Li Wang, Min-Yu Su, Pei-Chin Lin, Shih-Chung Wang, James S. Miser, Tai-Tong Wong, Yuan-Hung Wu, Peng Yuan Wang, Thierry Burnouf, Jeng-Fong Chiou, Long-Sheng Lu. Application of in vitro drug screening of circulating tumor cells in pediatric glioma therapy. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6723.
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Zhang, Xianyu, Shiyao Lu, Hui Li, Xin Liu, Jun Wang, Liuhong Zeng, Zhipeng Lu et al. "Abstract P1-05-27: Liquid Biopsy for HER2 Status Assessment in Breast Cancer Using Surrogate DNA Methylation Markers". Cancer Research 83, n. 5_Supplement (1 marzo 2023): P1–05–27—P1–05–27. http://dx.doi.org/10.1158/1538-7445.sabcs22-p1-05-27.
Testo completoAbstract (sommario):
Abstract Background: Emerging HER2-targeted drugs especially antibody–drug conjugates (ADCs) are promising and provide more options for breast cancer management. Current assessment of HER2 status and treatment decisions are mainly dependent on immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) on the primary tumor tissues. With the disease progression, the molecular status of the tumor may evolve and become discordant with the primary site. However, longitudinal monitoring of HER2 status is limited by infeasible repeated sampling of the tumor tissues. A non-invasive and accurate approach to obtaining real-time samples for measuring HER2 alterations is thus an unmet need for surveillance and guiding treatment selection in breast cancer. Detecting HER2 aberration in cell-free DNA (cfDNA) can allow repeated sampling and avoid effects from tumor heterogeneity of tissue biopsy. Previous approaches for HER2 status determination using liquid biopsy were mostly dependent on the detection of copy number changes in cfDNA, but the limited signal-to-noise ratio poses a great challenge to the accuracy and robustness of the tests. In this study, we identified a group of DNA methylation markers for determining HER2 status in cfDNA for breast cancer. Methods: Genome-wide DNA methylation sequencing was conducted in tissue (25 HER2-positive and 35 HER2-negative) and plasma (32 HER2-positive and 107 HER2-negative) samples to identify specific methylation markers for HER2 status. HER2-positive samples were defined by IHC 3+ and 2+ with FISH positive, while HER2-negative ones were IHC 0/1+ and 2+ with FISH negative. Candidate markers were verified in another two sets of plasma samples (1. 30 HER2-positive and 40 HER2-negative; 2. 33 HER2-positive and 53 HER2-negative) by using quantitative methylation-specific PCR (qMSP). The performance of the markers was estimated by the Wilcoxon test, receiver operating characteristic curve, and logistic regression modelling. Results: 36 HER2 status-specific markers were discovered from genome-wide DNA methylation sequencing. Based on the qMSP results, 11 markers were verified by the performance analyses. The individual area under the curve (AUC) of these markers was from 0.58 to 0.68. From logistic regression modelling and 2-fold cross-validation, a 7-marker diagnostic model was built and validated on plasma samples, with the highest AUC of 0.812. Conclusion: cfDNA methylation detection inferring HER2 overexpression is a novel and non-invasive option for monitoring HER2 status in breast cancer patients, with a potential application in response prediction of HER2-targeted treatments. Further validation of the test is undergoing in large multi-centre cohorts in China. Citation Format: Xianyu Zhang, Shiyao Lu, Hui Li, Xin Liu, Jun Wang, Liuhong Zeng, Zhipeng Lu, Siyu Liu, Yanling Yin, Marina Bibikova, Zhiwei Chen, Jian-Bing Fan, Da Pang. Liquid Biopsy for HER2 Status Assessment in Breast Cancer Using Surrogate DNA Methylation Markers [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P1-05-27.
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Bhimla, Aisha, Wenyue Lu, Lin Zhu, Yin Tan, Di Zhu, Jade Truehart, Ming-Chin Yeh, Minhhuyen Nguyen e Grace X. Ma. "Abstract C087: Neighborhood influences on chronic hepatitis B monitoring behaviors among Asian Americans residing in Philadelphia county". Cancer Epidemiology, Biomarkers & Prevention 32, n. 1_Supplement (1 gennaio 2023): C087. http://dx.doi.org/10.1158/1538-7755.disp22-c087.
Testo completoAbstract (sommario):
Abstract The incidence of liver and intrahepatic bile duct cancer for Asian Americans is almost 2 times greater in comparison to Non-Hispanic white women and men. A major factor that contributes to liver cancer is hepatitis b (HBV) infection, which disproportionally affects Asian Americans, who represent 7% of the total US population but makes up around 58% of HBV-linked hepatocellular carcinoma cases. The purpose of this study was to examine the relationship between the neighborhood environment, including neighborhood walkability, Asianicity, and neighborhood disadvantage on HBV monitoring related behavior such as doctors' visits and HBV blood testing among Asian HBV patients. A total of 160 study participants were recruited from March 2019 to March 2020 through combined recruitment approaches, including through medical record review by authorized staff from collaborating health clinics, pharmacies, or community health centers and community-based organizations including racial/ethnic based educational and community centers, religion-based organizations, and senior centers. Study measures included baseline assessment information including sociodemographics, HBV infection history, HBV monitoring behavior, and knowledge about HBV prevention, diagnosis and treatment. Neighborhood level measures included neighborhood disadvantage, Asianicity, and neighborhood walkability using census and online measures. Hierarchical generalized linear models (HGLM) were used to account for individual nested within neighborhoods for predicting factors associated with doctor’s visits and blood test. Greater neighborhood disadvantage (OR=0.97, 95% CI=0.95-0.99, p=0.0041) and Asianicity (OR=0.97, 95% CI=0.95-0.98, p=0.0003), and lower neighborhood walkability (OR=1.06, 95% CI=1.02-1.09, p=0.0039) were associated with a lower likelihood of doctor visits for CHB. Greater Asianicity (OR=0.97, 95% CI=0.96-0.99, p=0.0044) was associated with a lower likelihood of HBV blood testing in the past 6 months. Evident neighborhood environment effects suggest the need to incorporate these factors into interventions to enhance HBV self-monitoring behaviors and slow disease progression of chronic HBV. Citation Format: Aisha Bhimla, Wenyue Lu, Lin Zhu, Yin Tan, Di Zhu, Jade Truehart, Ming-Chin Yeh, Minhhuyen Nguyen, Grace X. Ma. Neighborhood influences on chronic hepatitis B monitoring behaviors among Asian Americans residing in Philadelphia county [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr C087.
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Lu, Feng, Weiqun Ding, Guangliang Yang, Yaoqing Jia, Zhaoxiang Wang, Xusheng Yuan, Ming Yin, Zhijian Yang e WenQing Yang. "Abstract LB364: Generation and Application of a Robust Humanized Mouse Tumor Model System for Evaluation of NK-Targeting Therapeutics". Cancer Research 84, n. 7_Supplement (5 aprile 2024): LB364. http://dx.doi.org/10.1158/1538-7445.am2024-lb364.
Testo completoAbstract (sommario):
Abstract With the new waves of anti-tumor immunotherapy development, novel immunotherapies based on NK cells have emerged and advanced rapidly. Considering the inherent mechanisms of NK cells, various strategies are employed in tumor immunotherapy to maximize the efficacy of NK cells, including the following: 1) immune checkpoint inhibitors to relieve NK cell inhibition signals; 2) activation of NK cell activity; 3) targeted antibody therapy for tumor cell killing via antibody-dependent cellular cytotoxicity (ADCC), and 4) cell therapy, such as CAR-NK. Although numerous NK-targeting immune therapeutics or various NK-modulating modalities have been developed or advanced toward clinical trials, there is a lack of clinically relevant preclinical animal models that can be widely accepted for the evaluation of NK-modulating agents, particularly for models that involve functional human NK cells in the test system. This study generated a humanized mouse tumor model system which involves specific reconstitution of functional and durable human NK cells in a murine system, providing a clinically relevant tumor microenvironment. We first engineered a stable monoclonal feeder cell line in vitro to expand NK cells isolated from human peripheral blood mononuclear cells (hPBMCs) using magnetic bead separation. Using this approach, the human primary NK cells were robustly and consistently amplified (up to hundreds of fold) while maintaining their purity and functionality. When compared with primary NK cells using in vitro immune assays including ADCC and FACs, the expanded NK cells showed comparable results as the parental cells. In vivo experimental results indicated that a durable and functional NK reconstitution can be established in tumor-bearing severely immune deficient mice expressing hIL-15. Furthermore, this NK-humanized tumor model system was proven to respond to standard of care (SOC) NK-targeting drugs. In summary, this novel NK humanized in vivo model may represent an effective preclinical tool for assessing NK-modulating drugs, with the hope of facilitating the development process of novel immune therapeutics employing both adaptive and innate immunity. Citation Format: Feng Lu, Weiqun Ding, Guangliang Yang, Yaoqing Jia, Zhaoxiang Wang, Xusheng Yuan, Ming Yin, Zhijian Yang, WenQing Yang. Generation and Application of a Robust Humanized Mouse Tumor Model System for Evaluation of NK-Targeting Therapeutics [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr LB364.
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Yang, Bing, Man Zhang, Yanmei Shi, Yi-Ming Dong, Xingyu Ma, Jingyuan Zhang, Daning Lu, Jian-You Liao e Dong Yin. "Abstract 3550: PerturbDB: A resource for revealing gene functions and cancer-associated phenotypes". Cancer Research 84, n. 6_Supplement (22 marzo 2024): 3550. http://dx.doi.org/10.1158/1538-7445.am2024-3550.
Testo completoAbstract (sommario):
Abstract Perturb-seq is a high-throughput technique that combines clustered regularly interspaced short palindromic repeats (CRISPR)-based screens with single-cell RNA sequencing (scRNA-seq) readouts for high-content phenotypic screens to comprehensively map the transcriptional effects of genetic perturbations, showing great advantages in revealing disease-associated gene functions and mechanisms in high volumes. Despite the rapid accumulation of Perturb-seq datasets, no dedicated database exists for reusing these valuable information. In this study, we developed a platform called PerturbDB (http://research.gzsys.org.cn/perturbdb) to facilitate users to unveil genotype-phenotype relations, especially gene functions and regulatory networks involved in several classical cancer associated phenotypes using 37 Perturb-seq datasets from 15 studies. By reanalyzing 3,429,829 single-cell transcriptomes from the knockdown of 3214 genes across 10 different cell lines, we identified 749 classical cancer phenotype-related genes and 373 functional gene clusters annotating potential novel functions. Utilizing Marker genes scoring and the InferCNV algorithm, we identified genes involved in 9 malignant phenotypes, which consists of sustaining proliferative signaling (362 genes), resisting cell death (120 genes), inducing angiogenesis (145 genes), tissue invasion and metastasis (321 genes), enabling replicative immortality (160 genes), deregulating cellular metabolism (247 genes), avoiding immune destruction (95 genes), unlocking phenotypic plasticity (231 genes), and chromosome instability (231 genes). Additionally, functional clusters were calculated utilizing Principal Component Analysis (PCAs) and the HDBSCAN package to introduce unknown gene functions related to the cancer associated phenotypes. Perturbation clusters (PCs) were identified by comparing similarities in the transcriptomes of perturbed cells, suggesting individual genes in the same functional cluster perform similar gene functions, and therefore novel functions of 735 genes can be inferred from the known functions of neighboring genes. The PGSEA tool was developed to facilitate functional analysis of genes not yet included, which helps users to predict gene functions through a combination of PerturbDB datasets and personalized RNA-seq datasets. This study will greatly expand our understanding of genes involved in emblematic cancer associated phenotypes and their coordinated functions and regulatory networks. Citation Format: Bing Yang, Man Zhang, Yanmei Shi, Yi-Ming Dong, Xingyu Ma, Jingyuan Zhang, Daning Lu, Jian-You Liao, Dong Yin. PerturbDB: A resource for revealing gene functions and cancer-associated phenotypes [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3550.
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WU, Peichen. "Traveling Japan, Writing Japan：The Translation and Publishing of the Travelogue Wareteki Nihon". Border Crossings: The Journal of Japanese-Language Literature Studies 13, n. 1 (30 dicembre 2021): 53–60. http://dx.doi.org/10.22628/bcjjl.2021.13.1.53.
Testo completoAbstract (sommario):
The travelogue Wareteki Nihon was published in December 2018 by Hakushui Sha, and included the work of eighteen Taiwanese writers from various generations. All their works in the text relate to their travels in Japan. These Taiwanese writers are Kan Yao-Ming, Ko Yu-fen, Huang Li-Chun, Wang Sheng-Hong, Jiang E, Chen Bo-Chin, Hu Mu-Ching, Sheng Hao-We, Chu He-Chih, Wu Ming-Yi, Lu Hui-Hsin, Yi Ge-Yan, Yen Shu-Hsia, and Liu Shu-Hui, whose works in this anthology depict Japanese scenery, culture and literature, and so on. This paper will focus on how this publishing project started, the process of producing this travelogue, and the evaluations and responses of Japan’s literary circle and the mass media to it after its publication in Japan.
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Lv, Hong, Qian-Ming Bai, Yin Liu, Zhong-Hua Wang, Ruo-Hong Shui, Hong-Fen Lu, Xiao-Li Xu et al. "Abstract P2-13-11: Response to anti-HER2 neoadjuvant chemotherapy in invasive breast cancers with different HER2 FISH-positive patterns". Cancer Research 82, n. 4_Supplement (15 febbraio 2022): P2–13–11—P2–13–11. http://dx.doi.org/10.1158/1538-7445.sabcs21-p2-13-11.
Testo completoAbstract (sommario):
Abstract Backgrounds: Since human epidermal growth factor receptor 2 (HER2)-positive breast cancers may have different HER2/CEP17 ratios and HER2 copy numbers, outcomes of HER2-positive breast cancer patients treated with anti-HER2 neoadjuvant chemotherapy (NACT) may be different. The aim of this study is to explore the relationship between different groups of HER2 fluorescence in situ hybridization (FISH) positive patterns and response to anti-HER2 NACT. Methods: 513 HER2-positive invasive breast cancers who received anti-HER2 NACT in Fudan University Shanghai Cancer Center, during January 2015 to September 2020, were collected. According to FISH results, 513 patients were divided into three groups. Group A: HER2/CEP17 < 2.0 and HER2 average copy number ≥6.0; Group B: HER2/CEP17≥2.0 and HER2 average copy number ≥4.0 and < 6.0; Group C: HER2/CEP17≥2.0 and HER2 average copy number ≥6.0. Clinicopathological characteristics and pathological complete response(pCR) rates of three groups were analyzed. Results: All 513 patients were treated with anti-HER2 NACT. The anti-HER2 treatment included trastuzumab in 463 (90.3%) patients, trastuzumab plus pertuzumab in 21 (4.1%) patients, trastuzumab plus lapatinib in 3 (0.6%) patients, and trastuzumab plus pyrotinib in 1 (0.2%) patient. 25 (4.9%) cases were unblinded in clinical trials, who were treated either with trastuzumab plus pertuzumab or with trastuzumab plus pyrotinib. Among 513 patients, 237 cases (46.2%)were luminal B (hormone receptor positive and HER2 positive) and 276 cases (53.8%) were hormone receptor negative and HER2 overexpressed (HER2 overexpression type). According to IHC results, cases with HER2 1+,2+ and 3+ were 8 (1.6%), 123 (24.0%) and 382(74.5%), respectively. Among them, 0.0%, 25.2%, and 48.7% achieved pCR (p<0.001). The pCR rate of HER2 overexpression type was higher than that of luminal B type (54.0% vs 28.7%, P<0.001). Lymph nodes with metastasis after NACT in luminal B type was higher than that of HER2 overexpression type (43.0% vs 21.4%, P<0.001). According to HER2-FISH results, 11 cases (2.1%) were group A, 28 cases (5.5%) were group B and 474 cases (92.4%) were group C. Compared with the pCR rate of group A (36.4%) and group C (44.5%), the pCR rate in group B (7.1%) was significantly lower (p<0.001). Conclusions: Among HER2-positive breast cancers, HER2 protein expression level was positively correlated with pCR rate. Luminal B(HER2+)patients benefited less from anti-HER2 NACT than HER2 overexpression patients. Although all were invasive breast cancers with positive HER2-FISH results, patients with HER2/CEP17≥2.0 and HER2 copy number ≥4.0 and <6.0 seemed to respond less favorably to anti-HER2 NACT compared with other groups. The biological characteristics of this group of patients are worthy of further study. Citation Format: Hong Lv, Qian-Ming Bai, Yin Liu, Zhong-Hua Wang, Ruo-Hong Shui, Hong-Fen Lu, Xiao-Li Xu, Bao-Hua Yu, Xiao-Yu Tu, Rui Bi, Yu-Fan Cheng, Xiao-Yan Zhou, Zhi-Min Shao, Wen-Tao Yang. Response to anti-HER2 neoadjuvant chemotherapy in invasive breast cancers with different HER2 FISH-positive patterns [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P2-13-11.
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T, Aswathi, Ammu Surendran, Harsha Enale, Angelina Sarapulova, Qiang Fu, Michael Knapp, Ditty Dixon e Aiswarya Bhaskar. "(Digital Presentation) Cobalt-Free Spinel-Layered Composite As a Positive Electrode for Sodium-Ion Batteries". ECS Meeting Abstracts MA2022-02, n. 4 (9 ottobre 2022): 443. http://dx.doi.org/10.1149/ma2022-024443mtgabs.
Testo completoAbstract (sommario):
Sodium-ion battery (NIB) system is an emerging technology and can be considered as a suitable alternative for lithium-ion batteries (LIBs) due to the large abundance and distribution of sodium on earth and similar working principles to LIB. Among those cathodes for NIBs, layered transition metal oxides (NaxMO2) receive more attention because of their higher capacity, appropriate operating potentials, higher ionic conductivity, and ease of synthesis [1]. According to the stacking sequence of oxygen layers and Na occupation sites, layered transition metal oxides are mainly classified as P2, O3, P3, and O2 structures. The letters P and O imply that the sodium occupies trigonal prismatic sites and octahedral sites, respectively. The numbers indicate the no. of oxygen stacking layers [2]. Among these, the P2 type layered transition metal oxides gained more recognition as cathode materials for NIBs due to their superior rate capability from the migration of sodium ions through the face-sharing trigonal prismatic sites [3]. However, the intercalation/de-intercalation of large sodium ions creates some structural deterioration and irreversibility. Designing multiphase materials is an effective strategy to improve the electrochemical performance of the material to avail the synergistic effects from each phase [3,4]. In this work, a cobalt-free layered-spinel composite was synthesized by sol-gel method as positive electrode material for NIBs. It is highly attractive, as it is cobalt-free and hence, cost-effective and environmentally benign. The layered phase provides a smoother diffusion pathway and the spinel phase could enhance the electronic conductivity [3,4]. The presence of layered and spinel phases was confirmed by the X-ray diffraction technique. Scanning electron microscopic investigations reveal particles of layered morphology with well-defined edges. The electrochemical investigations were done in Na-half cells in the voltage range of 1.5- 4.0 V vs. Na+/Na. The cyclic voltammogram of the layered-spinel composite in Na half-cell shows two sets of peaks corresponding to the redox activity of Mn and Ni. When the upper cut-off voltage was increased above 4 V, contributions from the Fe electrochemical activity were also observed. To investigate the sodium storage performance, galvanostatic charge-discharge studies were done. The material displayed an initial discharge capacity of 171 mAh g-1 and promising high-rate behavior. To investigate the electrochemical mechanism, in operando X-ray absorption spectroscopic studies were done and the results will be discussed in detail. Acknowledgement A.Bhaskar gratefully acknowledges financial support from “DST-IISc Energy Storage Platform on Supercapacitors and Power Dense Devices” through the MECSP-2K17 program under grant no. DST/TMD/MECSP/2K17/20”. D. Dixon acknowledges the financial support from SERB, New Delhi, India through Ramanujan Fellowship, under the grant number SB/S2/ RJN-162/2017. A. Thottungal is grateful to CSIR New Delhi for the CSIR SRF grant and AcSIR, Ghaziabad- 201002, India. DESY, Hamburg, Germany is acknowledged for the beamtime allocation at the P65 beamline at PETRA III and the beamline scientist Dr. Edmund Welter is acknowledged for his support. This work contributes to the research performed at CELEST, and was partially funded by the DFG under Project ID 390874152 (POLiS Cluster of Excellence). Reference D. Slater , D. Kim , E. Lee and C. S. Johnson , Adv. Funct. Mater., 2013, 23 , 947 —958 Delmas, C. Fouassier and P. Hagenmuller, Phys. B, 1980, 99, 81 Zheng, P. Yan, W. H. Kan, C. Wang and A. Manthiram, J. Electrochem. Soc., 2016, 163(3), A584 Hou , J. Yin , X. Lu , J. Li , Y. Zhao and X. Xu , Nanoscale, 2018, 10 , 6671 —6677
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Zhu, Di, Danny Bracy, Wenyue Lu, Lin Zhu, Elizabeth Handorf, Yin Tan, Ming-chin Yeh, Minhhuyen T. Nguyen e Grace X. Ma. "Abstract B109: Depression is a risk factor for noncompliance with antiviral medication treatment among Asian Americans with chronic hepatitis B". Cancer Epidemiology, Biomarkers & Prevention 32, n. 1_Supplement (1 gennaio 2023): B109. http://dx.doi.org/10.1158/1538-7755.disp22-b109.
Testo completoAbstract (sommario):
Abstract Introduction: Asian Americans is a Hepatitis B (HBV) disparity population who only account for 6% of the US population but experience a 60% burden of having HBV, which is associated with 75% of hepatocellular carcinoma (HCC). Adherence to HBV medication is a practical approach to prevent liver cancer. However, limited studies have been conducted on the impacts of depression on HBV medication adherence among underserved Asian American HBV patients. Methods: This study utilized 12-m follow up data from a randomized controlled clinical trial aimed at improving long-term adherence to HBV medication adherence. Eligible Asian American HBV patients were recruited from the Greater Philadelphia Area and New York City. HBV medication adherence was assessed using the 8-Item Morisky Medication Adherence Scale (MMAS-8), and depression was measured with Patient Health Questionnaire-9 (PHQ-9). We conducted OLS regression to examine the association between depression and medication adherence among participants who reported that they were taking antiviral medication for their chronic hepatitis B condition. Results: Among 154 participants (118 Chinese and 36 Vietnamese), 43.57% were female, and 56.49% were male. Nearly all the participants reported having health insurance (92.21%) and having a physician to visit regularly (95.21%). Bivariate analysis showed that depression was negatively significantly associated with medication adherence score (r=-0.55, p<0.001). Multivariable analysis revealed that a higher level of depressive symptoms at baseline significantly predicted poor medication adherence (log odds: -0.16, 95% CI: 4.02-6.89), with other covariates controlled for. In addition, study arm and ethnicity were significant predictors of medical adherence as well. Conclusion: The findings suggest that depression level has significant impacts on medication adherence. This indicates the need for mental health monitoring for CHB patients on antiviral. There are needs for culturally sensitive clinical and community interventions to improve mental health status and medication adherence among this vulnerable population. In addition, we will discuss the successes and challenges in the participant recruitment and intervention implementation process of this study. Citation Format: Di Zhu, Danny Bracy, Wenyue Lu, Lin Zhu, Elizabeth Handorf, Yin Tan, Ming-chin Yeh, Minhhuyen T. Nguyen, Grace X. Ma. Depression is a risk factor for noncompliance with antiviral medication treatment among Asian Americans with chronic hepatitis B [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr B109.
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Li, Jie, Nan Hu, Yilu Zhang, Xiaolong Yang, Minjuan Deng, Wenfeng Gong, Longbo Yin et al. "Abstract 6158: BGB-24714, a novel oral IAP antagonist, displayed significant anti-tumor activities in preclinical models as a monotherapy and in combination with paclitaxel". Cancer Research 83, n. 7_Supplement (4 aprile 2023): 6158. http://dx.doi.org/10.1158/1538-7445.am2023-6158.
Testo completoAbstract (sommario):
Abstract Background: Evasion of apoptosis is identified as one of the essential hallmarks of cancer and upregulation of inhibitor of apoptosis proteins (IAPs) is one of the mechanisms by which tumor cells evade apoptosis. An oral SMAC mimetic and antagonist of cellular IAP1 (cIAP1) and X-linked IAP (XIAP), BGB-24714, is currently investigated in a phase 1a/1b oncology trial in patients with advanced or metastatic solid tumors (NCT05381909). Here, we evaluated the anti-tumor activity of BGB-24714 as a single agent or in combination with paclitaxel in preclinical models. Results: BGB-24714 effectively inhibited cIAP1 by inducing its degradation in MDA-MB-231 cells, with an EC50 of 2.5 nM. BGB-24714 also potently antagonized the inhibitory interaction of XIAP with caspase-9 and induced caspase-9 autoactivation in MDA-MB-231 cells, with an EC50 of 23 nM. In a total of 25 breast cancer cell lines treated with TNFα, BGB-24714 potently inhibited the in vitro proliferation of 5 breast cancer cells with EC50 < 100 nM. In pharmacodynamics studies, single dose administration of BGB-24714 significantly induced degradation of cIAP1 and antagonism of the XIAP: Smac interaction in the MDA-MB-231 xenograft model in a dose dependent manner. Using the same model, BGB-24714 exhibited dose-dependent anti-tumor activities as a single agent. The tumor growth inhibition rates were 30%, 52% and 73% in low to high dosage treatment groups. Furthermore, BGB-24714 at medium dosage level demonstrated synergized anti-tumor activity in HCC1806 xenograft model when used in combination with paclitaxel. In intermittent dosing study, BGB-24714 with the intermittent dosing schedule demonstrated significant but slightly less effective anti-tumor activity than the continuous dosing schedule. In summary, BGB-24714, as a novel oral IAP antagonist, showing significant anti-tumor activities in preclinical models, which is promising and warrants the testing of the compound in human. Citation Format: Jie Li, Nan Hu, Yilu Zhang, Xiaolong Yang, Minjuan Deng, Wenfeng Gong, Longbo Yin, Yong Liu, Yajuan Gao, Wei Wei, Xing Wang, Xinyi Liang, Yanwen Ma, Xuxing Sang, Chang Liu, Jingyuan Wang, Qianqian Lu, Fengtao Song, Xi Yuan, Yibing Wang, Jing Li, Wei Jin, Xuesong Liu, Xiaomin Song. BGB-24714, a novel oral IAP antagonist, displayed significant anti-tumor activities in preclinical models as a monotherapy and in combination with paclitaxel [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6158.
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Zhang, Xu Hannah, Vu N. Ngo, Natalie Sandoval, Qi Cui, Yanhong Shi, Jasmine M. Zain, Christiane Querfeld, Chao Guo, Xiwei Wu e Steven T. Rosen. "Role of p38γ - NFATc4 - IL17A Pathway As a Potential Therapeutic Target in Cutaneous T Cell Lymphoma". Blood 128, n. 22 (2 dicembre 2016): 2725. http://dx.doi.org/10.1182/blood.v128.22.2725.2725.
Testo completoAbstract (sommario):
Abstract Cutaneous T cell lymphoma (CTCL) is an incurable skin homing T cell malignancy. We have previously reported p38 as therapeutic targets for CTCL.1 However, the mechanism underlying p38 signaling is not completely understood. To further investigate p38 and its downstream signaling components, we examined public database of gene expression and found that p38γ is overexpressed in CTCL as compared to normal T cells. In addition, p38γ has negligible expression in normal lymphoid tissues, with the exception of high level expressed in smooth and cardiac muscle cells. We have demonstrated that p38γ over-expression increases cell proliferation and knockdown of p38γ causes Hut78 cell death. p38γ plays an important role in inflammation-associated tumorigenesis3 and inhibition of its activity has emerged as a strategy to treat a spectrum of cancers.4 The transcription factor, NFATc4, downstream of p38γ, is also significantly up-regulated in CTCL cells by microarray analysis, and it is at non-detectable level in normal T cells.1We have demonstrated that shRNA-mediated knockdown of p38γ reduced NFATc4 mRNA levels in Hut78 cells, and that inhibition of NFATc4 by siRNA reduces the proliferation of CTCL cells. We also found that the cytokine IL17A functions downstream of p38γ and NFATc4, as knockdown of either p38γ or NFATc4 significantly reduced IL17A mRNA levels in Hut78 cells. This result suggests that IL17A is a target for transcriptionally activated NFATc4. Previously we have shown that IL17A rescues Hut78 cells from apoptosis induced by combined inhibition of NFAT and NFkB (treated with curcumin and Ly2228820). This implicates IL17A as a key mediator for CTCL survival. Therefore, we propose a novel p38γ - NFATc4 - IL17A signaling pathway in malignant T cells that promotes the survival of CTCL which provides potential therapeutic target against this disease. To further define the role of p38 and identify targets that increase the antitumor efficacy of p38 inhibition, we performed a synthetic lethal RNA interference (RNAi) screen in Hut78 cells treated with 10 µM of the p38 MAPK inhibitor Ly2228820. We transduced control and Ly2228820-treated Hut78 cells with a pooled retroviral RNAi library consisting of 4290 shRNAs that targeted more than 1000 genes involved in human cancers. If a shRNA from the library is not toxic to the control cells, but causes cell death in Ly2228820-treated cells, the gene targeted by this shRNA would be identified by the screen as synthetically lethal to p38 inhibition. Among many hits identified from the screen, we selected UCHL5 for further analysis. UCHL5encodes a deubiquitin enzyme that cleaves K48-linked polyubiquitin chains and plays an important role in the regulation of protein stability. Interestingly, combination of Ly2228820 and b-AP15, a small molecule inhibitor of UCHL5, significantly reduced the protein levels of NFATc4 isoform but not other NFAT isoforms. NFATc4 protein levels are known to be regulated by ubiquitin-proteasome pathway.2 Our finding thus suggests UCHL5 as a potential new regulator that stabilizes NFATc4 protein. Further studies are needed to confirm this prediction. More importantly, combination of Ly2228820 and b-AP15 enhanced apoptosis in CTCL cell lines (HH and Hut78) and primary Sézary cells, but was not toxic in normal PBMC cells. In summary, our findings suggest that the p38γ - NFATc4 - IL17A signaling pathway plays an important role in the survival of CTCL. In addition, improving the efficacy of targeting this pathway via p38 may also benefit from combined inhibition of UCHL5, a potentially important regulator of NFATc4 that needs further characterization. Reference: 1 Bliss-Moreau M, Coarfa C, Gunaratne PH, Guitart J, Krett NL, Rosen ST (2015). Identification of p38beta as a therapeutic target for the treatment of Sezary syndrome. The Journal of investigative dermatology135:599-608. 2 Fan Y, Xie P, Zhang T, Zhang H, Gu D, She M et al (2008). Regulation of the stability and transcriptional activity of NFATc4 by ubiquitination. FEBS letters582:4008-4014. 3 Qi X, Yin N, Ma S, Lepp A, Tang J, Jing W et al (2015). p38gamma MAPK Is a Therapeutic Target for Triple-Negative Breast Cancer by Stimulation of Cancer Stem-Like Cell Expansion. Stem cells33:2738-2747. 4 Yin N, Qi X, Tsai S, Lu Y, Basir Z, Oshima K et al (2015). p38gamma MAPK is required for inflammation-associated colon tumorigenesis. Oncogene. Disclosures Querfeld: Actelion: Membership on an entity's Board of Directors or advisory committees; Celgene: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau.
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Zhou, Liheng, Shuguang Xu, Xiaohong Xue, Yinzhou Zhang, Bei Gu, Baoxing Lin, Junwen Bai et al. "Abstract P2-12-02: Efficacy, safety and survival of neoadjuvant chemotherapy with different estrogen deprivation stratified by menstrual status versus chemotherapy alone in locally advanced breast cancer (SHPD002)—— A randomized multicentre, open-label, phase 3 Triab". Cancer Research 82, n. 4_Supplement (15 febbraio 2022): P2–12–02—P2–12–02. http://dx.doi.org/10.1158/1538-7445.sabcs21-p2-12-02.
Testo completoAbstract (sommario):
Abstract BackgroundAchieving pathologic complete response (pCR) because of neoadjuvant therapy has been correlated with long-term clinical benefit, however, luminal-like tumors achieve a lower rate of pCR in comparison with other subtypes. The Shanghai Pudong (SHPD) 002 trial compares neoadjuvant chemotherapy concurrently with or with different estrogen deprivation therapy separately in premenopausal and postmenopausal patients with locally advanced breast cancer. MethodsIn this prospective, multicentre, neoadjuvant, phase III trial, 236 patients with locally advanced breast cancer were randomly assigned (2:1) to receive neoadjuvant chemotherapy (NCT) with gonadotropin-releasing hormone agonist (GnRHa) in premenopausal women or letrozole in postmenopausal women compared with chemotherapy alone. The primary endpoint was pCR (ypT0/is/ypN0). Secondary endpoints included disease-free survival, overall survival, and safety. This trial is registered with ClinicalTrials.gov, number NCT NCT02221999.Results A total of 236 patients were included. pCR was achieved by 20.4% in the chemotherapy plus ET group and 38.6% in the chemotherapy group. In postmenopausal patients, pCR was observed in 22.6% when treated with letrozole, 32.4% with NCT alone (p=0.276). Premenopausal patients with NCT and GnRHa achieved a significantly lower pCR of 18.8% than those of 42.9% in patients with NCT alone(p=0.003). A posthoc analysis showed CPS+EG score 0-3 was significantly more probable in patients with GnRHa (OR, 0.245; 95% CI, 0.072 to 0.832, P=0.024) than in those without GnRHa in the premenopausal patients who didn’t achieve near-pCR. After a median follow-up of 45 months, there was no significant difference concerning disease-free survival (DFS) (p=0.874) or overall survival (OS) (P =0.947) between the 2 postmenopausal groups. GnRHas significantly improved survival outcome in premenopausal patients (3-year OS, 100% with GnRHas, vs 88.2% without; log-rank p=0.034). Improved DFS (log-rank p = 0.001) and OS (log-rank p=0.003) were strongly associated with pCPS+EG score and GnRHa usage in premenopausal patients.ConclusionsConcurrent administration of GnRHas during neoadjuvant chemotherapy improves OS in premenopausal patients, though it does not increase the pCR rate. The adoption of the CPS+EG score may be a better surrogate endpoint for survival outcomes. The addition of letrozole to neoadjuvant chemotherapy confers no therapeutic advantage in terms of tumor response or survival outcome. Citation Format: Liheng Zhou, Shuguang Xu, Xiaohong Xue, Yinzhou Zhang, Bei Gu, Baoxing Lin, Junwen Bai, Hongwei Zhang, Kejin Wu, Yanping Lin, Yumei Ye, Yueyao Du, Xiaonan Sheng, Yaqian Xu, Jie Zhang, Wenjin Yin, Jinsong Lu. Efficacy, safety and survival of neoadjuvant chemotherapy with different estrogen deprivation stratified by menstrual status versus chemotherapy alone in locally advanced breast cancer (SHPD002)—— A randomized multicentre, open-label, phase 3 Triab [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P2-12-02.
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Kim, Ellen J., LIn Zhu, Wenyue Lu, Safa Ibrahim, Steven Zhu, Nathaly Rubio-Torio, Evelyn González et al. "Abstract B056: Increasing knowledge of colorectal cancer (CRC) risk factors and screening through a community-based education initiative". Cancer Epidemiology, Biomarkers & Prevention 32, n. 1_Supplement (1 gennaio 2023): B056. http://dx.doi.org/10.1158/1538-7755.disp22-b056.
Testo completoAbstract (sommario):
Abstract Background: Colorectal cancer (CRC) screening such as colonoscopy and stool test has been shown to be effective in reducing CRC burden, especially in the underprivileged communities. However, CRC awareness and screening uptake remained suboptimal, especially in racial/ethnic minority populations and non-Hispanic whites. Both CRC incidence and mortality rates are highest in non-Hispanic blacks (approximately 20% and 40%, respectively), and CRC screening uptake rates are lower in racial/ethnic minorities relative to non-Hispanic whites (NHWs). The cause for the disparities in incidence and mortality is multifactorial. One important aspect is the suboptimal knowledge and awareness of risk factors. Methods: To increase awareness of CRC prevention and screening, we collaborated with community-based organizations (CBOs) to develop culturally tailored educational materials targeting African/Black Americans (BAs), Asian Americans (AAs), and Hispanic Americans (HAs). The topics included essential CRC and screening knowledge, a healthy diet (Mediterranean diet), and at-home workout routines. Eligible participants from the Greater Philadelphia area and New York City participated in one-time education. Pre- and post-intervention surveys were designed based on the Colorectal Cancer Quiz provided by the Centers for Disease Control and Prevention (CDC) and were administered to assess the immediate impact of the educational sessions. Results: The analysis sample included 413 participants, among which 388 completed the post-survey. One in ten (10.3%) reported a family history of CRC, and a half (50.6%) had never had a colonoscopy. The baseline CRC knowledge score was 9.5 out of 16, indicating a moderately low level of knowledge. Participants scored particularly low on the age of CRC screening initiation, needs for screening even without symptoms, and the impact of physical activity on CRC risk. The knowledge score significantly increased to 10.9 (p < .001) at post-survey, indicating a significant impact of the educational workshops. Conclusion: The findings of our project confirm that the CRC screening rates are low in racial/ethnic minorities compared to the U.S. national rate of 71.6%. Meanwhile, it also confirmed that culturally tailored, community-based educational initiatives can effectively raise knowledge of CRC in medically underserved populations. Citation Format: Ellen J. Kim, LIn Zhu, Wenyue Lu, Safa Ibrahim, Steven Zhu, Nathaly Rubio-Torio, Evelyn González, Marilyn A. Fraser, Ming-Chin Yeh, Grace X. Ma, Olorunseun O. Ogunwobi, Yin Tan. Increasing knowledge of colorectal cancer (CRC) risk factors and screening through a community-based education initiative [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr B056.