Articoli di riviste: "Vcakd"

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Lin, Wei Min, Hitoshi Ohmori, T. Suzuki, Yoshihiro Uehara, Y. Watanabe e Shinya MORITA. "Characteristics of Free Form Finishing Applying V-CAM System". Key Engineering Materials 329 (gennaio 2007): 273–78. http://dx.doi.org/10.4028/www.scientific.net/kem.329.273.

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A new CAD system, which is called Volume-CAD (VCAD) have been developed. We carried out research and development of VCAD fabrication process based on VCAD/CAM precision control. In this study, a developed V-CAM had been used for a polishing fundamental experiment of a free form surface. The relationship between NC resolution and form accuracy of polished surface are discussed.

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Pasha, Tayyab, Rafaqat Ahmed, Muhammad Amir, Amir Iqbal e Ayesha Siddiqa. "EARLY OUTCOMES". Professional Medical Journal 23, n. 05 (10 maggio 2016): 583–88. http://dx.doi.org/10.29309/tpmj/2016.23.05.1588.

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Objectives: Off pump TACR/MACR performed in experienced hands hascomparable results to on pump TACR/MACR. Period: January-2012 to December-2015.Material and method: 405 patients with two and three vessel coronary artery disease (two &three VCAD) underwent OPCAB at the department of cardiac surgery, Jinnah hospital, Lahore.73 of them got total or multiple arterial coronary revascularizations. 34 patients (41%) hadtwo VCAD and 47 (59%) had three VCAD. Total arterial revascularization was performed in 70(95.8%) patients using right internal mammary artery and left internal mammary artery and/orradial artery. 3 (4.10%) patients got multiple arterial grafts using BITA, RA and SVG. Results:There was no death reported in first 30 days post operatively. Deep sternal wound infectionoccurred in only one patient. The rate of perioperative stroke and renal failure was zero. Two(2.46%) patients had acute MI and 1 patient was reopened due to bleeding. Conclusion: Weconclude that early outcome of OPCAB total or multiple arterial coronary revascularizations, inexperienced hands, are as safe and effective as ONCAB.

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MASUDA, Takatoshi, e Toshio NAGASHIMA. "165 Nonlinear stress analysis using VCAD Framework". Proceedings of The Computational Mechanics Conference 2006.19 (2006): 583–84. http://dx.doi.org/10.1299/jsmecmd.2006.19.583.

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YOKOTA, Hideo. "S203 Development of VCAD Tools for Biomedical Simulation". Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2008.21 (2009): 341–42. http://dx.doi.org/10.1299/jsmebio.2008.21.341.

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Imai, N., T. Nagashima e K. Kase. "Crack propagation simulator V-X3D based on VCAD framework". IOP Conference Series: Materials Science and Engineering 10 (1 giugno 2010): 012053. http://dx.doi.org/10.1088/1757-899x/10/1/012053.

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NISHIMURA, Masaomi, Tetsuro MURAI, Masakatsu TSUNEKI, Yutaka OTAKE, Hideo YOKOTA, Kiwamu KASE, Ryutaro HIMENO e Akitake MAKINOUTI. "523 Design of tailor made implants using VCAD system". Proceedings of the JSME annual meeting 2006.5 (2006): 101–2. http://dx.doi.org/10.1299/jsmemecjo.2006.5.0_101.

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Ohura, K., Z. Sun, Akitake Makinouchi e Cristian Teodosiu. "Volume-CAD: An Integrated Environment for Virtual Manufacturing and Structural Analysis". Advanced Materials Research 23 (ottobre 2007): 17–24. http://dx.doi.org/10.4028/www.scientific.net/amr.23.17.

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The Volume-CAD System Research Program aims at developing a core technology for data integration of computerized design, analysis, manufacturing, and testing processes. The potential applications of the Volume-CAD environment cover a large area of engineering and biomedical design. In this paper, we shall mainly focus on the VCAD-based software for the structural analysis and the simulation of casting processes.

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Cronin, Blaise, e Yvonne Rogers. "From Victorian visiting card to vCard: the evolution of a communicative genre". Journal of Information Science 29, n. 1 (febbraio 2003): 65–68. http://dx.doi.org/10.1177/016555150302900108.

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Yun, Se-Mi, e Ik-Seong Jo. "The Design and Implementation of Web Agents for vCard Service in Mobile Enviromnent". KIPS Transactions:PartD 9D, n. 3 (1 giugno 2002): 477–86. http://dx.doi.org/10.3745/kipstd.2002.9d.3.477.

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Simoni, Laura, Alessandra Scarton, Claudio Macchi, Federico Gori, Guido Pasquini e Silvia Pogliaghi. "Quantitative and Qualitative Running Gait Analysis through an Innovative Video-Based Approach". Sensors 21, n. 9 (23 aprile 2021): 2977. http://dx.doi.org/10.3390/s21092977.

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Quantitative and qualitative running gait analysis allows the early identification and the longitudinal monitoring of gait abnormalities linked to running-related injuries. A promising calibration- and marker-less video sensor-based technology (i.e., Graal), recently validated for walking gait, may also offer a time- and cost-efficient alternative to the gold-standard methods for running. This study aim was to ascertain the validity of an improved version of Graal for quantitative and qualitative analysis of running. In 33 healthy recreational runners (mean age 41 years), treadmill running at self-selected submaximal speed was simultaneously evaluated by a validated photosensor system (i.e., Optogait—the reference methodology) and by the video analysis of a posterior 30-fps video of the runner through the optimized version of Graal. Graal is video analysis software that provides a spectral analysis of the brightness over time for each pixel of the video, in order to identify its frequency contents. The two main frequencies of variation of the pixel’s brightness (i.e., F1 and F2) correspond to the two most important frequencies of gait (i.e., stride frequency and cadence). The Optogait system recorded step length, cadence, and its variability (vCAD, a traditional index of gait quality). Graal provided a direct measurement of F2 (reflecting cadence), an indirect measure of step length, and two indexes of global gait quality (harmony and synchrony index). The correspondence between quantitative indexes (Cadence vs. F2 and step length vs. Graal step length) was tested via paired t-test, correlations, and Bland–Altman plots. The relationship between qualitative indexes (vCAD vs. Harmony and Synchrony Index) was investigated by correlation analysis. Cadence and step length were, respectively, not significantly different from and highly correlated with F2 (1.41 Hz ± 0.09 Hz vs. 1.42 Hz ± 0.08 Hz, p = 0.25, r2 = 0.81) and Graal step length (104.70 cm ± 013.27 cm vs. 107.56 cm ± 13.67 cm, p = 0.55, r2 = 0.98). Bland–Altman tests confirmed a non-significant bias and small imprecision between methods for both parameters. The vCAD was 1.84% ± 0.66%, and it was significantly correlated with neither the Harmony nor the Synchrony Index (0.21 ± 0.03, p = 0.92, r2 = 0.00038; 0.21 ± 0.96, p = 0.87, r2 = 0.00122). These findings confirm the validity of the optimized version of Graal for the measurement of quantitative indexes of gait. Hence, Graal constitutes an extremely time- and cost-efficient tool suitable for quantitative analysis of running. However, its validity for qualitative running gait analysis remains inconclusive and will require further evaluation in a wider range of absolute and relative running intensities in different individuals.

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Michikawa, Takashi, Kiwamu Kase, Yutaka Ohtake, Zhigang Sun, Cristian Teodosiu e Akitake Makinouchi. "3113 Hexahedral Mesh Generation by VCAD and Dual Meshes for Structural Analysis". Proceedings of Design & Systems Conference 2006.16 (2006): 282–83. http://dx.doi.org/10.1299/jsmedsd.2006.16.282.

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Cronin, B., e Y. Rogers. "Brief Communication. From Victorian visiting card to vCard: the evolution of a communicative genre". Journal of Information Science 29, n. 1 (1 gennaio 2003): 65–68. http://dx.doi.org/10.1177/016555103762202096.

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Luo, Zhi Feng, Chao Sun e Shun Xiang Wu. "Fetching Address Book Info of iPhone OS". Advanced Materials Research 204-210 (febbraio 2011): 1266–69. http://dx.doi.org/10.4028/www.scientific.net/amr.204-210.1266.

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With the rapid development of mobile technology, the mobile phones has gradually become an indispensable part in everybody’s life, and it is replacing the computer’s position step by step. The iPhone is a smart phone made of Apple Company, which opens a new era of software for mobile devices. At the same time, iOS(iPhone’s operating system) has become one of most competitive mobile communications operating systems. The Apple’s protection for security makes the iPhone owners hardly control their phone through the root (highest authority). It is so difficult to manage the information effetely with iPhone, such as contacts’ information or SMS. The paper introduced two approaches to get the contacts’ information in iPhone and restore them with vCard. At last, we managed the output file on MAC.

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MAKINOUCHI, Akitake. "S201 VCAD system : a base for integrating modeling and simulation of multiple processes". Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2008.21 (2009): 337–38. http://dx.doi.org/10.1299/jsmebio.2008.21.337.

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IMAI, Noboru, Toshio NAGASHIMA e Kiwamu KASE. "1306 Implementation of crack propagation simulation to VCAD based analysis software V-X3D". Proceedings of The Computational Mechanics Conference 2009.22 (2009): 364–65. http://dx.doi.org/10.1299/jsmecmd.2009.22.364.

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MAKINOUCHI, Akitake. "W03(1) Integration of modeling and simulation processes based on VCAD system environment". Reference Collection of Annual Meeting 2006.8 (2006): 273–74. http://dx.doi.org/10.1299/jsmemecjsm.2006.8.0_273.

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Itani, Norihiko, Y. Watanabe, W. Lin, Y. Uehara, Shinya MORITA, T. Mishima, Hitoshi Ohmori e Akitake Makinouchi. "R&D of Ray Tracing Simulation Software and Fabrication Technologies Based on VCAD (Volume-CAD) Concept for GRIN Lens". Key Engineering Materials 381-382 (giugno 2008): 109–12. http://dx.doi.org/10.4028/www.scientific.net/kem.381-382.109.

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We have been developing an intellectual manufacturing process applying IT (V-Cam system fabrication processes) based on Volume-CAD (VCAD) system which can express internal information of materials. This paper introduces the ultra-precision grinding, ray tracing (optical path) simulation software ‘V-Opt’ and the measurement of actual optical functions in the development of optical element taking gradient refractive index (GRIN) lens with functionally graded material properties as a model. In finish ground GRIN lens using SD#8000 wheel, the P-V (Peek to Value) of 27.07 nm, surface roughness (Ra) of 1.83 nm is obtained. ‘V-Opt’ developed for GRIN lens have two main functions; one is the visualizations of ray tracing and the other is the evaluation of spot diagram and focal length.

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KASE, Kiwamu, Takashi KANAI e Yutaka OHTAKE. "WS4-3 The outline of Volume-CAD and implicit surfaces on VCAD modeling(2)". Proceedings of the Fluids engineering conference 2006 (2006): _WS4–3–1_—_WS4–3–4_. http://dx.doi.org/10.1299/jsmefed.2006._ws4-3-1_.

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KASE, Kiwamu, Takashi KANAI e Yutaka OHTAKE. "WS4-3 The outline of Volume-CAD and implicit surfaces on VCAD modeling(1)". Proceedings of the Fluids engineering conference 2006 (2006): _WS4–3—a_. http://dx.doi.org/10.1299/jsmefed.2006._ws4-3-a_.

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Akbar, Mochamad Dandi, e Antoni Antoni. "Aplikasi Absensi Pegawai pada Dinas Komunikasi dan Informatika Kabupaten Deli Serdang dengan QR Code Menggunakan Algoritma Bcrypt". sudo Jurnal Teknik Informatika 1, n. 1 (25 marzo 2022): 8–16. http://dx.doi.org/10.56211/sudo.v1i1.2.

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Pengelolaan absensi data pada kantor dinas kominfo kabupaten deli serdang ini masih secara manual dengan tanda tangan pada buku absen. Rekapitulasi kehadiran juga dilakukan secara manual yakni dengan mencatat dan menghitung jumlah pegawai yang hadir, sakit atau tanpa keterangan. Proses rekapitulasi tersebut membutuhkan ketelitian yang tinggi untuk menghindari kekeliruan dalam perhitungan jumlah kehadiran. Selain itu, kelemahan dari absensi manual tersebut dapat terjadi kecurangan yang mungkin dilakukan berupa URL, nomor telepon, pesan SMS, VCard, atau teks apapun. Penelitian ini ini dilakukan untuk mengatasi masalah tersebut dengan menggunakan teknologi QR Code berbasis web. QR Code merupakan kode yang mampu menyimpan dan memberikan data dengan respon dengan cepat. Metode yang digunakan adalah Metode Bcrypt yang berfungsi untuk mengenkripsi password agar password menjadi lebih aman dan tidak mudah dibaca oleh orang lain. Aplikasi yang digunakan adalah aplikasi berbasis web dengan jenis website yang digunakan adalah website dinamis dan dengan menggunakan bahasa pemograman yaitu PHP lalu menggunakan database sebagai tempat penyimpanan.

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Soulimane, Ghizlene, Belkacem Kouninef, Mohamed Senouci e Mohamed Djelti. "QR Codes and Mobile Technology Used in the Blended Learning Approach". International Journal of Technology Diffusion 7, n. 4 (ottobre 2016): 1–13. http://dx.doi.org/10.4018/ijtd.2016100101.

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The purpose of this article is to explore the teaching processes that use Quick Response (QR) codes and mobile devices to support blended learning at the National Institute of Telecommunications and ICT (INTTIC). The satisfactory results of our previous research show that the use of mobile technology could enhance accessibility and communication in a blended learning course. In Algeria, the mobile penetration rate stands at over 111% and 21% with 3G. Since most of our students have access to mobile technology, three in five were smartphones. Using this technology would encourage students to use their phones to send questions to their teachers, listen to a podcast and snip the quick response (QR) codes. This paper introduces the implementations of QR codes, vcard and QR voice as a new tool in the Moodle platform in our institute. The QR code contains the URL of the page of one particular Moodle course and quiz are added to the bottom of Moodle. The students' satisfaction had been acknowledged as an important factor in order to estimate the effectiveness of a blended learning course.

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Nimmy, Sonia Farhana, e M. S. Kamal. "Next generation sequencing under de novo genome assembly". International Journal of Biomathematics 08, n. 05 (13 agosto 2015): 1530001. http://dx.doi.org/10.1142/s1793524515300018.

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The next generation sequencing (NGS) is an important process which assures inexpensive organization of vast size of raw sequence dataset over any traditional sequencing systems or methods. Various aspects of NGS such as template preparation, sequencing imaging and genome alignment and assembly outline the genome sequencing and alignment. Consequently, de Bruijn graph (dBG) is an important mathematical tool that graphically analyzes how the orientations are constructed in groups of nucleotides. Basically, dBG describes the formation of the genome segments in circular iterative fashions. Some pivotal dBG-based de novo algorithms and software packages such as T-IDBA, Oases, IDBA-tran, Euler, Velvet, ABySS, AllPaths, SOAPde novo and SOAPde novo2 are illustrated in this paper. Consequently, overlap layout consensus (OLC) graph-based algorithms also play vital role in NGS assembly. Some important OLC-based algorithms such as MIRA3, CABOG, Newbler, Edena, Mosaik and SHORTY are portrayed in this paper. It has been experimented that greedy graph-based algorithms and software packages are also vital for proper genome dataset assembly. A few algorithms named SSAKE, SHARCGS and VCAKE help to perform proper genome sequencing.

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Malov, Igor’ F., e Oleg I. Malov. "The Cluster Analysis of Pulsar Parameters". International Astronomical Union Colloquium 160 (1996): 57–58. http://dx.doi.org/10.1017/s0252921100041038.

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We have used the catalogue of (Taylor et al., 1993) to investigate the problem of a classification of pulsars. Five samples have been analysed by the main components method and by methods of the cluster analysis.i)15 pulsars with 14 known parameters P, Ṗ, W50,L(Malov et al., 1994),B,z,spectral indexa, frequencies of maximumVMand minimumVcin a spectrum (Malofeev et al., 1994), an angle between magnetic moment and rotation axisβ(Malov, 1994), the transformation coefficientη=L/Ė, magnetic field near the light cylinderBlcand a maximum derivative of a position angleC= (dψ/dφ)max(Malov, 1990).ii)130 objects with 10 parameters (the spectral characteristicsα,VM,VCand the parameter C were excluded from the consideration).iii)218 pulsars with 4 known parameters P, Ṗ, L andz. These parameters can be considered as independent variables.iv)89 sources with the same 4 parameters. This sample consists of two subsamples: 65 pulsars withP> 1 s and 24 ones withP< 0.1 s.v)24 pulsars withP< 0.1 s from the previous sample.

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Firmansyah, Fahmi, Maulida Dwi Kartikasari, Makmur Sujarwo, Teguh Budi Raharjo e Dien Noviany Rahmatika. "Peran Otoritas Jasa Keuangan Dalam Pencegahan Fintech Illegal di Masyarakat". Permana : Jurnal Perpajakan, Manajemen, dan Akuntansi 14, n. 1 (28 febbraio 2022): 168–79. http://dx.doi.org/10.24905/permana.v14i1.215.

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Technological advances have an impact on aspects of life. The emergence of technological finance in online loans makes it easy to get the desired funds in a short and easy process. There are many cases of illegal fintech that we can see in national and international media. One example is the case of the VLoan application owned by PT Vcard Technology Indonesia. The purpose of this research is to see and analyze the role of the Financial Services Authority in preventing illegal activities in society, because the rampant illegal fintech in society is certainly detrimental to several parties. This research uses qualitative research with high-performance qualitative analysis application tools, namely NVivo 12. Based on the research results, the role of the Financial Services Authority in preventing illegal fintech by means of education and socialization has been effective. Obstacles in preventing illegal fintech, namely the low level of public understanding of online loans, low levels of financial literacy. This research is also expected to be a relevant source for the future. Keyword: Finansial Teknologi Illegal, Otoritas Jasa Keuangan, Pencegahan Fraud

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Ohmori, H., Y. Uehara, W. Lin, Y. Watanabe, K. Katahira, T. Naruse, N. Mitsuishi e S. Ishikawa. "New ELID Grinding Technique for Desk-top Grinding System Based on VCAD Concept(Nanoprecision Elid-grinding (continued))". Proceedings of International Conference on Leading Edge Manufacturing in 21st century : LEM21 2005.2 (2005): 703–8. http://dx.doi.org/10.1299/jsmelem.2005.2.703.

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Darma, I. Made, e Putu Jadnya. "Legal Protection of Parties in Online Credit Agreement (Peer to Peer Lending) A Case Study of PT Vcard Technology Indonesia". PADJADJARAN Jurnal Ilmu Hukum (Journal of Law) 06, n. 03 (dicembre 2019): 511–32. http://dx.doi.org/10.22304/pjih.v6n3.a5.

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The development of digital economy has led people to adapt to the use of services in information-technology-based loan or peer-to-peer lending. In early 2019, the V-loan case attracted attention of many people. The case has made debtors depressed, removed from their own houses, etc. Some debtors even were fired from works. In a case, the loan provider misused debtors’ personal data in debtors’ cell phones. The loan provider created WhatsApp groups containing all debtors’ contacts, including the debtors. Then, they uploaded pornographic content. Their objective was to defame debtors. Parties involved in loan agreement should adhere rules and arrange for reasonable loan. To discuss this matter, it is necessary to review agreement based on the Law on Electronic Information and Transaction and the Regulation of Financial Services Authority number 77 of 2016. The study focused on legal protection of parties involving in P2P lending activities. The credit agreement of peer-to-peer lending is considered valid if it is based on Article 47 of the Government Regulation number 82 of 2016. Standard contract must be based on Article 20 of the Regulation of Financial Services Authority number 77 of 2016. Electronic signature is also required based on Article 41 of the Regulation. In addition, the application of information technology and electronic transactions must be carried out based on the principles of legal certainty, benefits, good faith, and the freedom of choice of technology based on Article 3 of Law Number 19 of 2016. Principles and objectives are fundamental elements of legal certainty. Therefore, organizer and the government must protect user of peer-to-peer lending.

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Darma, I. Made, e Putu Jadnya. "Legal Protection of Parties in Online Credit Agreement (Peer to Peer Lending) A Case Study of PT Vcard Technology Indonesia". PADJADJARAN Jurnal Ilmu Hukum (Journal of Law) 06, n. 03 (dicembre 2019): 511–32. http://dx.doi.org/10.22304/pjih.v6n3.a5.

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Abstract (sommario):

The development of digital economy has led people to adapt to the use of services in information-technology-based loan or peer-to-peer lending. In early 2019, the V-loan case attracted attention of many people. The case has made debtors depressed, removed from their own houses, etc. Some debtors even were fired from works. In a case, the loan provider misused debtors’ personal data in debtors’ cell phones. The loan provider created WhatsApp groups containing all debtors’ contacts, including the debtors. Then, they uploaded pornographic content. Their objective was to defame debtors. Parties involved in loan agreement should adhere rules and arrange for reasonable loan. To discuss this matter, it is necessary to review agreement based on the Law on Electronic Information and Transaction and the Regulation of Financial Services Authority number 77 of 2016. The study focused on legal protection of parties involving in P2P lending activities. The credit agreement of peer-to-peer lending is considered valid if it is based on Article 47 of the Government Regulation number 82 of 2016. Standard contract must be based on Article 20 of the Regulation of Financial Services Authority number 77 of 2016. Electronic signature is also required based on Article 41 of the Regulation. In addition, the application of information technology and electronic transactions must be carried out based on the principles of legal certainty, benefits, good faith, and the freedom of choice of technology based on Article 3 of Law Number 19 of 2016. Principles and objectives are fundamental elements of legal certainty. Therefore, organizer and the government must protect user of peer-to-peer lending.

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Desclee, Doriane, David Sohinto e Freddy Padonou. "Sustainability Assessment and Agricultural Supply Chains Evidence-Based Multidimensional Analyses as Tools for Strategic Decision-Making—The Case of the Pineapple Supply Chain in Benin". Sustainability 13, n. 4 (14 febbraio 2021): 2060. http://dx.doi.org/10.3390/su13042060.

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Contributing to Sustainable Development Goals and Agenda 2030 is a shared objective of all institutions and people. The challenges differ according to the characteristics of every context. In developing countries, strongly dependent on the agricultural sector, agricultural supply chains are recognized as crucial for economic growth and enablers for livelihood improvement. Moreover, sustainable development issues are correlated and can meet in agricultural supply chains. For several decades, parallel to decision-makers, the research community has elaborated sustainability assessment tools. Such tools evolved to fit with actuality, but it is challenging to find decision-making support tools for sustainable development adequate in agricultural supply chains and developing countries contexts. There is a necessity to define evidence-based tools and exhaustive analytical frameworks according to sustainability multidimensionality and strategical tradeoffs necessity. The VCA4D method aims to go beyond the limits of previous methods. It proposes a combination of multidisciplinary analytical tools applied empirically to analyze agricultural supply chains in their context. It provides evidence-based analytical results allowing to identify enablers for strategic sustainable and inclusive interventions. However, to even better meet contextual exhaustiveness’s expectations and indicators’ robustness to lead to relevant interventions, we should insist on a stricter framing of contextual data collection processes.

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Jarosz, Krzysztof, Piotr Niesłony e Piotr Löschner. "The effect of changes in depth of cut and cutting speed of CNC toolpaths on turning process performance". Archives of Mechanical Technology and Materials 38, n. 1 (22 agosto 2018): 40–44. http://dx.doi.org/10.2478/amtm-2018-0007.

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Abstract In this article, a novel approach to computer optimization of CNC toolpaths by adjustment of cutting speed vcand depth of cut apis presented. Available software works by the principle of adjusting feed rate on the basis of calculations and numerical simulation of the machining process. The authors wish to expand upon this approach by proposing toolpath optimization by altering two other basic process parameters. Intricacies and problems related totheadjustment of apand vcwere explained in the introductory part. Simulation of different variant of the same turning process with different parameter values were conducted to evaluate the effect of changes in depth of cut and cutting speed on process performance. Obtained results were investigated on the account of cutting force and tool life. The authors have found that depth of cut substantially affects cutting force, while the effect of cutting speed on it is minimal. An increase in both depth of cut and cutting speed affects tool life negatively, although the impact of cutting speed is much more severe. An increase in depth of cut allows for a more significant reduction of machining time, while affecting tool life less negatively. On the other hand, the adjustment of cutting speed helpsto reduce machining time without increasing cutting force component values and spindle load.

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Fukasaku, K., M. Negoro, H. Iwase, K. Yokoi e R. Himeno. "Computational Fluid Dynamics for Brain Circulation and Aneurysm with Therapeutic Devices". Interventional Neuroradiology 10, n. 2_suppl (dicembre 2004): 108–12. http://dx.doi.org/10.1177/15910199040100s220.

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We analysed fluid dynamics at brain arteries having multiple inflow and out flow like Willis ring based on clinical imaging modalities. In addition, we analysed fluid dynamics with therapeutic devices like coils and stents to simulate their influences to blood flow. 3D CTA and MRA obtained three-dimensional structures of the brain vessels. The centreline was obtained from the three dimensional structure. Diameter of the blood vessels was measured by 3D CTA/MRA then smooth surfaced blood vessel models were created. For the fluid analysis, we developed a home brew software which can display parameters such as streamline, etc. In addition, our CFD (computational fluid dynamics) software can work in collaboration with a CAD (computer aided design) software which we also developed (VCAD: Volume CAD). So, therapeutic devices such as coils, balloons and stents could be placed in the models and CFD analysis could be performed placing devices in the models. The flow pattern in the complicated vascular structure could be calculated such as Willis ring which has multiple inputs like ICA, VA and multiple outlets like MCA and PCA with communicating arteries. CFD with therapeutic devices could also analysed with our system.

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Watanabe, Yutaka, Hitoshi Ohmori, Weimin Lin, Yoshihiro Uehara, Toru Suzuki, Shin-ya Morita, Nobuhide Mitsuishi e Akitake Makinouchi. "Development of Aspherical Gradient Index (GRIN) Lens Fabrication System based on VCAD Concept and ELID Grinding(Nanoprecision Elid-grinding (continued))". Proceedings of International Conference on Leading Edge Manufacturing in 21st century : LEM21 2005.2 (2005): 697–702. http://dx.doi.org/10.1299/jsmelem.2005.2.697.

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Usman, Hafiz Tahir, Kashif Ali Hashmi, Mohammad Sohail Saleemi e Ammar Akhtar. "ASSOCIATION OF ST ELEVATION IN LEAD AVR WITH LEFT MAIN STEM AND TRIPLE VESSEL DISEASES IN PATIENTS WITH NON-ST ELEVATION MYOCARDIAL INFARCTION". Pakistan Heart Journal 54, n. 4 (8 gennaio 2022): 348–51. http://dx.doi.org/10.47144/phj.v54i4.2128.

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Objectives: To determine frequency of left main stem (LMS) and triple vessel coronary artery disease (3VCAD) in patients of Non-ST-elevation myocardial infarction (NSTEMI) and to compare the frequency of LMS and 3VCAD in patients with NSTEMI with or without ST elevation in lead aVR. Methodology: Total 346 patients with NSTEMI having age 30-70 years were included in this descriptive cross-sectional study. The data on demographic details was collected. All patients underwent electrocardiography (ECG) and cardiac specific troponin-I assessment. Patients were categorized as NSTEMI with or without ST-elevation in lead aVR. Coronary angiography was performed in all patients and angiographic findings were noted. Results: Mean age of patients was 51.87±10.03 years. There were 218 (63.01%) males and 128 (36.99%) female patients. 182 (52.60%) patients of NSTEMI had ST elevation in aVR. LMS disease was found in 53 (29.10%) patients with ST elevation in aVR. Sensitivity, specificity, positive predive value and negative predictive value of ST elevation in aVR for LMS disease was 62.35%, 50.57%, 29.12% and 80.49% respectively. 3 VCAD was found in 54 (29.70%) with ST elevation in aVR. Sensitivity, specificity, positive predive value and negative predictive value of ST elevation in aVR for 3VCAD was 77.14%, 53.52%, 29.67% and 90.24% respectively. Conclusion: NSTEMI patients with ST elevation in aVR may have higher chances of having LMS disease or 3VCAD. There is high negative predictive value for ST elevation in aVR to predict LMS disease or 3VCAD.

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Shin, Sungho, Seongju Lee, Changhyun Jun e Kyoobin Lee. "BattleSound: A Game Sound Benchmark for the Sound-Specific Feedback Generation in a Battle Game". Sensors 23, n. 2 (10 gennaio 2023): 770. http://dx.doi.org/10.3390/s23020770.

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A haptic sensor coupled to a gamepad or headset is frequently used to enhance the sense of immersion for game players. However, providing haptic feedback for appropriate sound effects involves specialized audio engineering techniques to identify target sounds that vary according to the game. We propose a deep learning-based method for sound event detection (SED) to determine the optimal timing of haptic feedback in extremely noisy environments. To accomplish this, we introduce the BattleSound dataset, which contains a large volume of game sound recordings of game effects and other distracting sounds, including voice chats from a PlayerUnknown’s Battlegrounds (PUBG) game. Given the highly noisy and distracting nature of war-game environments, we set the annotation interval to 0.5 s, which is significantly shorter than the existing benchmarks for SED, to increase the likelihood that the annotated label contains sound from a single source. As a baseline, we adopt mobile-sized deep learning models to perform two tasks: weapon sound event detection (WSED) and voice chat activity detection (VCAD). The accuracy of the models trained on BattleSound was greater than 90% for both tasks; thus, BattleSound enables real-time game sound recognition in noisy environments via deep learning. In addition, we demonstrated that performance degraded significantly when the annotation interval was greater than 0.5 s, indicating that the BattleSound with short annotation intervals is advantageous for SED applications that demand real-time inferences.

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Karan, Radmila, Suzana Cvjeticanin, Natasa Kovacevic-Kostic, Dejan Nikolic, Milos Velinovic, Vladimir Milicevic e Biljana Obrenovic-Kircanski. "Genetic and Environmental Dispositions for Cardiovascular Variability: A Pilot Study". Journal of Clinical Medicine 7, n. 9 (23 agosto 2018): 232. http://dx.doi.org/10.3390/jcm7090232.

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Background: The aim of our study was to evaluate the degree of genetic homozygosity in the group of patients with coronary artery disease (CAD), as well as to evaluate morphogenetic variability in CAD patients regarding the presence of investigated risk factors (RF) compared to a control sample of individuals. Additionally, we aimed to evaluate the distribution of ABO blood type frequencies between tested samples of individuals. Methods: This study analyzed individual phenotype and morphogenetic variability of 17 homozygously-recessive characteristics (HRC), by using HRC test in a sample of 148 individuals in CAD patients group and 156 individuals in the control group. The following RF were analyzed: hypertension, diabetes mellitus, hyperlipidemia, and smoking. Results: The mean value of HRC in CAD patients is significantly higher, while variability decreases compared to the control sample (CAD patients: 4.24 ± 1.59, control sample: 3.75 ± 1.69; VCAD-patients = 37.50%, VC = 45.07%). There is a significant difference in individual variations of 17 HRC between control sample and CAD patients (χ2 = 169.144; p < 0.01), which points out to different variability for tested genes. Mean values of HRC significantly differed in CAD patients in regard to the number of RF present. A blood type (OR = 1.75) is significant predictor for CAD, while O blood type (OR = 0.43) was significantly associated with controls. Conclusion: There is a higher degree of recessive homozygosity in CAD patients versus individuals in the control sample, and the presence of significant variations in the degree of recessive homozygosity as the number of tested RF increases.

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Grayfer, Leon, Francisco De Jesús Andino e Jacques Robert. "Prominent Amphibian (Xenopus laevis) Tadpole Type III Interferon Response to the Frog Virus 3 Ranavirus". Journal of Virology 89, n. 9 (25 febbraio 2015): 5072–82. http://dx.doi.org/10.1128/jvi.00051-15.

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ABSTRACTRanaviruses (Iridoviridae) are posing an increasing threat to amphibian populations, with anuran tadpoles being particularly susceptible to these viral infections. Moreover, amphibians are the most basal phylogenetic class of vertebrates known to possess both type I and type III interferon (IFN)-mediated immunity. Moreover, little is known regarding the respective roles of the IFN mediators in amphibian antiviral defenses. Accordingly, we transcriptionally and functionally compared the amphibianXenopus laevistype I (IFN) and III (IFN-λ) IFNs in the context of infections by the ranavirus frog virus 3 (FV3).X. laevisIFN and IFN-λ displayed distinct tissue expression profiles. In contrast to our previous findings thatX. laevistadpoles exhibit delayed and modest type I IFN responses to FV3 infections compared to the responses of adults, here we report that tadpoles mount timely and robust type III IFN gene responses. Recombinant forms of these cytokines (recombinantX. laevisIFN [rXlIFN] and rXlIFN-λ) elicited antiviral gene expression in the kidney-derived A6 cell line as well as in tadpole leukocytes and tissues. However, rXlIFN-λ was less effective than rXlIFN in preventing FV3 replication in A6 cells and tadpoles and inferior at promoting tadpole survival. Intriguingly, FV3 impaired A6 cell and tadpole kidney type III IFN receptor gene expression. Furthermore, in A6 cultures rXlIFN-λ conferred equal or greater protection than rXlIFN against recombinant viruses deficient for the putative immune evasion genes, the viral caspase activation and recruitment domain (vCARD) or a truncated vIF-2α gene. Thus, in contrast to previous assumptions, tadpoles possess intact antiviral defenses reliant on type III IFNs, which are overcome by FV3 pathogens.IMPORTANCEAnuran tadpoles, including those ofXenopus laevis, are particularly susceptible to infection by ranavirus such as FV3. We investigated the respective roles ofX. laevistype I and type III interferons (IFN and IFN-λ, respectively) during FV3 infections. Notably, tadpoles mounted timely and more robust IFN-λ gene expression responses to FV3 than adults, contrasting with the poorer tadpole type I IFN responses. However, a recombinantX. laevisIFN-λ (rXlIFN-λ) conferred less protection to tadpoles and the A6 cell line than rXlIFN, which may be explained by the FV3 impairment of IFN-λ receptor gene expression. The importance of IFN-λ in tadpole anti-FV3 defenses is underlined by the critical involvement of two putative immune evasion genes in FV3 resistance to IFN- and IFN-λ-mediated responses. These findings challenge the view that tadpoles have defective antiviral immunity and suggest, rather, that their antiviral responses are predominated by IFN-λ responses, which are overcome by FV3.

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Aponte-Daza, Vaneska Cindy, Freddy Ponce Valdivia, Bismarck Pinto Tapia e Felipe Garcia. "Duelo anticipado y afrontamiento al estrés en cuidadores informales de personas de la tercera edad". LIBERABIT. Revista Peruana de Psicología 28, n. 2 (31 dicembre 2022): e621. http://dx.doi.org/10.24265/liberabit.2022.v28n2.621.

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Antecedentes: el duelo anticipado es el proceso por el que pasan algunas personas antes del fallecimiento de un ser querido o de que se confirme su muerte. Ocurre cuando varias circunstancias hacen prever que tarde o temprano un ser querido, como un familiar, una pareja o un amigo, va a morir. Objetivo: el objetivo de estudio fue conocer cuáles son las estrategias de afrontamiento al estrés y factores personales del cuidado y del cuidador que benefician o ponen en riesgo el duelo anticipado en cuidadores informales de personas de la tercera edad. Método: participaron 272 cuidadores informales. Se utilizó la Escala del Duelo en el Cuidador de Meichsner et al. (2016) y la Escala Breve de Afrontamiento al Estrés (COPE 28) de Carver (1997). Resultados: los resultados evidencian que el duelo anticipado es influenciado por el afrontamiento: el dolor emocional por el afrontamiento basado en apoyo (OR = .236), afrontamiento evasión a la emoción (OR = 3.751) y estar todo el día de cuidado (OR = 3.061). La pérdida emocional es estimada por el afrontamiento focalizado en el problema (OR = .201), cuando el cuidador es un adulto mayor (OR = .303) y por el medio tiempo de cuidado (OR = 2.029). La aceptación de la pérdida es influenciada por el afrontamiento focalizado al problema (OR = .172), afrontamiento evasión a la emoción (OR = 4.409), cuidador es adulto joven (OR = 2.361) y por el cuidado durante casi todo el día (OR = .536). Además, la pérdida absoluta se asoció con el afrontamiento focalizado en el problema (r = .249) y el afrontamiento de evasión con sustancias (r = .216). Conclusiones: este estudio logra identificar factores personales y tipos de afrontamiento al estrés que favorecen o disminuyen el duelo anticipado en el cuidador primario informal. Particularmente, la probabilidad de presentar dolor emocional aumenta de acuerdo al afrontamiento basado en el apoyo o el espiritual, pero disminuye con el afrontamiento basado en la evasión emocional y la mayor convivencia con el enfermo. Contribución de autoría VCAD: revisión bibliográfica, elaboración de la introducción, de la justificación, del planteamiento del problema, del marco teórico, selección de la población, toma de pruebas, y elaboración de resultados y conclusiones. FPV: vaciado de datos, elaboración de base de datos, análisis de datos, creación de tablas, elaboración del método, elaboración de resultados y conclusiones. BPT: profesor guía. FG: revisión del artículo y sugerencias de correcciones.

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Goebel, B., C. Salomon, M. Abdulrahman, S. Richter, M. El Garhy, E. Costello, H. Lapp e P. Lauten. "Echocardiographic predictors of the effectiveness of interventional edge-to-edge repair in tricuspid valve regurgitation". European Heart Journal 42, Supplement_1 (1 ottobre 2021). http://dx.doi.org/10.1093/eurheartj/ehab724.083.

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Abstract Background Percutaneous tricuspid valve edge-to-edge repair (pTVR) is a promising interventional technique for patients with tricuspid regurgitation (TR), but guidance regarding patient selection and echocardiographic screening is lacking. The aim of this study was to identify echocardiographic parameters which may predict pTVR success. Methods Before and after pTVR, echocardiographic data, including 3D full-volume datasets, were obtained and quantified. Right ventricular assessments included ejection fraction (RVEF3D) and diastolic (RVVd3D) and systolic (RVVs3D) volumes. Also evaluated were: right atrial (RA) volume, effective regurgitant orifice area by PISA method (EROAPISA), vena contracta area (VCA3D) by multiplanar reconstruction from a 3D colour Doppler loop (Figure 1a), maximal diastolic tricuspid annulus area from a 3D zoom image (Figure 1b), and tricuspid tenting area. TR severity was graded according to EROAPISA and VCA3D as grade 1+ to 5+. Results Patients (n=99, age 79±6 years, 48 male) with at least moderate to severe TR undergoing pTVR were consecutively included. The patients were divided into groups according to their post-pTVR TR grade. Group 1 had TR grade ≤2+, and group 2 had TR grade ≥3+.Echocardiographic parameters before pTVR for both groups are presented in Table 1. As expected, patients with TVR ≥3+ after pTVR had significantly worse pre-intervention echocardiographic measurements of TR severity, valve dimensions, and chamber volumes. ROC curves for the prediction of TR ≤2+ (mild to moderate) after pTVR (defined as VCA3D <0.75 cm2 and EROAPISA <0.4 cm2) were drawn for different echocardiographic features (Figure 2). VCA3D by 3D colour Doppler yielded the highest area under the ROC curve followed by TV anatomy measurements (Annulus area3D, Tenting area) and right atrial volume. Conclusion A thorough evaluation of TR and valve dimensions by 3D echocardiography, particularly the evaluation of VCA3D by 3D colour Doppler, aids in the prediction of the probability of pTVR success. Funding Acknowledgement Type of funding sources: None.

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Goebel, B., C. Salomon, H. Awada, E. Costello, N. Sassenberg, P. Lauten e H. Lapp. "Vena contracta area size predicts effectiveness of interventional edge-to-edge repair in tricuspid valve regurgitation". European Heart Journal - Cardiovascular Imaging 22, Supplement_1 (1 gennaio 2021). http://dx.doi.org/10.1093/ehjci/jeaa356.219.

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Abstract Funding Acknowledgements Type of funding sources: None. Background Percutaneous tricuspid valve edge-to-edge repair (pTVR) is a promising interventional technique for patients with tricuspid regurgitation (TR), but guidance regarding patient selection and echocardiographic screening is lacking. The aim of this study was to identify echocardiographic measurements which may predict pTVR success. Methods Before and after pTVR, echocardiographic data, including 3D full-volume datasets, were obtained and quantified. Right ventricular assessments included ejection fraction (RVEF3D) and diastolic (RVVd3D) and systolic (RVVs3D) volumes. Also evaluated were: right atrial (RA) volume, effective regurgitant orifice area by PISA method (EROAPISA), vena contracta area (VCA3D) by multiplanar reconstruction from a 3D colour Doppler loop (Figure 1a), maximal diastolic tricuspid annulus area from a 3D zoom image (Figure 1b), and tricuspid tenting area. TR severity was graded according to EROAPISA and VCA3D as grade 1+ to 5+. Results Patients (n= 44, age 72 ± 9 years, 20 male) with at least moderate to severe TR undergoing pTVR were consecutively included. The patients were divided into groups according to their post-pTVR TR grade. Group 1 had TR grade ≤2+, and group 2 had TR grade ≥3+.Echocardiographic parameters before pTVR for both groups are presented in Table 1. As expected, patients with TVR ≥3+ after pTVR had significantly worse pre-intervention echocardiographic measurements of TR severity, valve dimensions, and chamber volumes. ROC curves for the prediction of TR ≤2+ (mild to moderate) after pTVR (defined as VCA3D <0.75 cm² and EROAPISA <0.4 cm²) were drawn for different echocardiographic features (Figure 2). VCA3D by 3D colour Doppler yielded the highest area under the ROC curve followed by TV anatomy measurements (Annulus area3D, Tenting area) and right atrial volume. Conclusion A thorough evaluation of TR and valve dimensions by 3D echocardiography, particulary the evaluation of VCA3D by 3D colour Doppler, aids in the prediction of the probability of pTVR success. Abstract Figure.

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Lee, Elizabeth, Liqi Shu, Setareh Salehi Omran, Eric D. Goldstein, Thanh N. Nguyen, James E. Siegler, Farhan Khan, Christoph Stretz, Karen L. Furie e Shadi Yaghi. "Abstract TP173: Differential Outcomes and Treatment in Vertebral versus Carotid Artery Dissections: A National Inpatient Sample Study". Stroke 55, Suppl_1 (febbraio 2024). http://dx.doi.org/10.1161/str.55.suppl_1.tp173.

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Introduction: Cervical artery dissection (CAD) involves the carotid (CCAD) or vertebral artery (VCAD). However, limited studies have compared their clinical features and outcomes. Our study utilized a comprehensive nationwide database to discern these differences. Method: We examined non-traumatic CAD-diagnosed patients from the U.S. National Inpatient Sample (2005-2019) using ICD-9 and ICD-10 codes. The evaluation included patient demographics, comorbidities, in-hospital complications, treatment, and costs. Differences between CCAD and VCAD were assessed using survey-weighted stepwise backward logistic regression, followed by propensity score matched adjusted regressions for outcomes. Result: From 2005 to 2019, we identified 157,086 CAD admissions, of which 79.9% (125,477) were spontaneous CADs, with CCAD outnumbering VCAD (67,671 vs. 57,806). Compared to VCAD, CCAD was significantly associated with older age (54 [44-66] vs. 49 [37-62]), Black race (12.6% vs. 8.7%), atrial fibrillation (6.1% vs. 3.7%), hypertension (58.0% vs. 53.9%), fewer concurrent acute ischemic strokes (AIS) (22.1% vs. 24.7%), higher NIHSS (mean NIHSS 7 [2-16] vs. 2 [0-5]), extended stays (4 days [2-8] vs. 4 days [2-7]) and increased hospitalization charges ($52,005 [$25,759-$118,806] vs. $43,199 [$24,116-$85,701]); all P<0.05. Within the concurrent AIS group, the CCAD group also exhibited an increased likelihood for IV thrombolysis (10.7% vs. 5.7%) and mechanical thrombectomy (14.9% vs. 3.7%). After propensity score matching for NIHSS and age, the CCAD group was associated with less death (adjusted odds ratio [aOR] 0.41, 95% CI 0.26-0.65, P<0.001) but a similar home discharge rate (aOR 1.15, 95% CI 0.78-1.69, P=0.480) (Figure). Conclusion: Our study underscores distinct comorbidity profiles and treatment patterns between CCAD and VCAD groups. These findings advocate for tailored treatment strategies based on dissection type to optimize patient outcomes.

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Jing, Zongxu, Changming Zhang, Xiangtao LI, Huan Zhang, Luyuan Niu, Yaping Feng, Yong Liu, Yunlong Yue, Xuemei Du e Xiaoyun Luo. "Cystic Adventitial Disease of the Popliteal Vein: A Case Report". Vascular and Endovascular Surgery, 27 settembre 2022, 153857442211308. http://dx.doi.org/10.1177/15385744221130842.

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Venous cystic adventitial disease (VCAD) is a rare vascular anomaly located in the common femoral vein in most cases. We describe the case of a 59-year-old female patient with right leg edema who was misdiagnosed with deep vein thrombosis of the lower extremity at another hospital. Magnetic resonance angiography revealed a round mass in the popliteal vein, with a narrow lumen. Considering the location of the lesion, absence of a history of deep venous thrombosis and trauma, and clinical manifestations, the diagnosis is likely a popliteal vein adventitial cyst. Segmental popliteal vein resection and reconstruction were performed using a cylindrical great saphenous vein graft. No joint connection was found during the operation, and the postoperative pathology confirmed VCAD.

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"3D and 4D US for Congenital Defects". Donald School Journal of Ultrasound in Obstetrics and Gynecology 4, n. 4 (2010): 349–60. http://dx.doi.org/10.5005/jp-journals-10009-1155.

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ABSTRACT Invent of 3D and 4D ultrasound has made a dramatic improvement in fetal imaging. Various viewing directions and rendering modes help better demonstration of pathologies suspected on 2D US. Multiplanar mode is the key of the 3D US imaging. Software like magicut and TUI help to understand the anatomy better. Volume ultrasound is an excellent tool for diagnosis of facial defects, spinal abnormalities, limb abnormalities, etc. 4D US shows fetal movements and expressions that are basis for the neurodevelopment of the fetus. STIC and VCAD are the tools that have made detection of fetal cardiac anomalies more precise.

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Goebel, B., C. Salomon, M. Abdulrahman, S. Richter, M. El Garhy, L. Costello-Boerrigter, H. Lapp e P. Lauten. "Effect of interventional edge-to-edge repair in tricuspid regurgitation on ring dimensions". European Heart Journal 42, Supplement_1 (1 ottobre 2021). http://dx.doi.org/10.1093/eurheartj/ehab724.0111.

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Abstract Background The concept of percutaneous tricuspid valve edge-to-edge repair (pTVR) is based on the connection of leaflets in the area of insufficiency using a coaptation device. By closing the coaptation device a considerable tractive force is applied on the leaflets, which might have an effect on the valve ring. Aim of the study was to examine the impact of device implantation on tricuspid ring dimensions. Methods During pTVR 3D zoom loops of tricuspid valve were acquired before and after clip placement using transoesophageal echocardiography. Measurements of TV ring dimensions included the following parameters: ring area (TV area), maximal diameter, minimal diameter, eccentricity index (Figure 1). Tenting area was derived from a four-chamber view of the valve. In addition, regurgitation severity was graded from 1+ to 5+ by measuring vena contracta area (VCA3D) in 3D full volume colour Doppler loop using multiplanar reconstruction. Right atrial (RA) and ventricular volumes (RVVd3D, RVVs3D) and function (RVEF3D) were assessed in a 3D full volume loop. Results The study population comprised 97 patients (age 78±6 years, 47 male), who underwent pTVR at our hospital. As expected cavity dimension correlated with TV area size (for RVVd3D r=0.51, p<0.001 and for RA volume r=0.71, p<0.001). The mean TV ring area was significantly reduced (ring area 8.53±2.23 cm2/m2BSA vs. 7.55±2.18 cm2/m2BSA, p<0.001) and the ring shape became more oval (Eccentricity index 1.2±0.15 vs. 1.29±0.17, p<0.001) after pTVR. The reduction of ring area (12±7%, range 0.7–28%) showed an only modest correlation to the number of implanted coaptation devices (r=0.30, p<0.001) and percentage reduction of VCA3D (r=0.36, p<0.001). In the patient group with a ring area change ≥12% a reduction to TR grade ≤2+ by pTVR was achieved in 83% of cases, whereas only 62% of patients reached moderate TR when area change was below 12%. Conclusion pTVR using coaptation devices reduces the ring area. This effect is related to the number of devices implanted. Funding Acknowledgement Type of funding sources: None.

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Goebel, B., C. Salomon, M. Abdulrahman, S. Richter, M. El Garhy, L. Costello-Boerrigter, H. Lapp e P. Lauten. "Effect of interventional edge-to-edge repair in tricuspid regurgitation on dimensions of the annulus". European Heart Journal - Cardiovascular Imaging 23, Supplement_1 (1 febbraio 2022). http://dx.doi.org/10.1093/ehjci/jeab289.135.

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Abstract Funding Acknowledgements Type of funding sources: None. Background The technique of percutaneous tricuspid valve edge-to-edge repair (pTVR) depends upon the connection of leaflets in the area of regurgitation using a coaptation device. By closing the coaptation device a considerable tractive force is applied on the leaflets, which might have an effect on the valve annulus. The aim of this study was to examine the impact of device implantation on tricuspid annular dimensions. Methods During pTVR, 3D zoom loops of the tricuspid valve (TV) were acquired before and after clip placement using transesophageal echocardiography. Measurements of TV annular dimensions included the following parameters: annulus area (TV area), maximal diameter, minimal diameter, and eccentricity index (Figure 1). Tenting area was derived from a four-chamber view of the valve. Tricuspid regurgitation (TR) severity was graded from 1+ to 5+ by measuring vena contracta area (VCA3D) in 3D full volume color Doppler loop using multiplanar reconstruction. Right atrial (RA) and ventricular volumes (RVVd3D, RVVs3D) and function (RVEF3D) were assessed in a 3D full volume loop. Results The study population consisted of 97 patients (age 78 ± 6 years, 47 male), undergoing pTVR at our hospital. As expected, cavity dimension correlated with TV area size (for RVVd3D r = 0.51, p < 0.001 and for RA volume r = 0.71, p < 0.001). The mean TV annular area was significantly reduced (Annular area 8.53 ± 2.23 cm²/m²BSA vs. 7.55 ± 2.18 cm²/m²BSA, p < 0.001) and the shape of the annulus became more oval (Eccentricity index 1.2 ± 0.15 vs. 1.29 ± 0.17, p < 0.001) after pTVR. The reduction in annular area (12 ± 7%, range 0.7-28%) was only modestly correlated with the number of implanted coaptation devices (r = 0.30, p < 0.001) and the percentage reduction of VCA3D (r =0.36, p < 0.001). In the patient group with an annular area change ≥12%, a decrease in TR grade to ≤2+ by pTVR was achieved in 83% of cases, whereas only 62% of patients achieved moderate TR when the change in area was below 12%. Conclusion pTVR using coaptation devices reduces the area of the TV annulus. This effect may be modestly correlated to the number of devices implanted. Abstract Figure.

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Ambroziak, M., J. Franke, A. Wojcicka, M. Kolanowska e A. Budaj. "SYNE1 gene novel variant is associated with myocardial infarction in young people with a family history of premature atherosclerosis". European Heart Journal 44, Supplement_2 (novembre 2023). http://dx.doi.org/10.1093/eurheartj/ehad655.3263.

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Abstract Introduction Genetic background is thought to be responsible for a family occurred premature atherosclerosis, including myocardial infarction (MI). Purpose The aim of the study was to investigate the role of genetic variants in young patients (aged <50 years) with MI and family history of premature atherosclerosis. Methods The studied group consisted of 70 patients aged 26-49 (mean 43.1, SD ±4.3), 17 women and 53 men, with MI and with family history of premature atherosclerosis, defined as MI or ischaemic stroke in first-degree relatives at age <65 years in women or <55 years in men. The mean BMI in the studied group was 28.8 kg/m2 (SD ±3.5), total cholesterol level 202.3 mg/dl (SD ±3.5), HDL 40.6 mg/dl (SD ±9.6), LDL 124.0 mg/dl (SD ±28.9), triglycerides 164.4 mg/dl (SD ±63.5), glucose 108.3 mg/dl (SD ±19.9) and creatinine 0.9 mg/dl (SD ±0.2). Regarding other risk factors 63 patients (90%) were smokers (mean 24.1 pack-years, SD ±13.0), 44 (62.8%) had hypertension, 11 (15.7%) had diabetes mellitus, and 8 (11.4%) had depression. All patients had diagnosed MI including MI with ST elevation (STEMI) in 18 cases (25.7%) and MI without ST elevation (NSTEMI) in 52 cases (74.3%). All patients, except 2 (no consent), had performed coronary angiography revealing 1-vessel coronary artery disease (VCAD) in 33 patients (47.1%), 2-VCAD in 17 patients (24.3%), and 3-VCAD in 20 patients (28.6%). The mean left ventricular ejection fraction (LVEF) was 51.8% (SD ±8.0). The total DNA has been extracted from whole peripheral blood samples. The targeted enrichment library was prepared and analyzed using New Generation Sequencing method on Hiseq4000, 2x150 cycles. Statistical analyses were performed using the R software package (www.r-project.org/). The results of sequencing were compared to data from the reference control population consisting of 597 healthy people (418 women, 179 men) aged 18-83 (mean 40.5, SD ± 12,4) as a whole and after matching with a studied group by age and gender in a proportion 1:3 (210 people, 51 women and 159 men, aged 18-77, mean 42.1, SD ±10.6) using Propensity Score Matching. Risks associated with detected variants were evaluated using Fisher’s exact test based on the allelic frequencies of variants in both groups. Results SYNE1 gene variant rs36215567 (NM_182961.4: c.20396+22A>G) has been detected in statistically significant higher incidence in the studied group in comparison to the control population (p=0.005) with OR=4,80 (95%CI 1,43-14,45) as well as when compared to the control population matched by age and gender (p=0.004) OR=9,31 (95%CI 1,64-95,41). There were no statistically significant differences in the incidence of familial hypercholesterolemia related gene variants: LDLR c.667G>A, PCSK9 c.658-36G>A, PCSK9 c.996+55C>A and APOB c.12382G>A between both cohorts. Conclusion A novel variant of SYNE1 gene is associated with myocardial infarction in young age patients with a family history of premature atherosclerosis.

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Goebel, B., C. Salomon, M. Abdulrahman, S. Richter, M. El Garhy, L. Costello-Boerrigter, H. Lapp e P. Lauten. "Impact of endocardial leads on the effectiveness of interventional edge-to-edge repair of tricuspid regurgitation". European Heart Journal 42, Supplement_1 (1 ottobre 2021). http://dx.doi.org/10.1093/eurheartj/ehab724.082.

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Abstract Background A considerable proportion of patients who are considered for percutaneous tricuspid valve edge-to-edge repair (pTVR) interventions have endocardial lead induced tricuspid regurgitation (TR). The aim of this study was to examine the impact of lead-leaflet interaction on the effectiveness of pTVR. Methods For each patient, the lead position within the tricuspid valve (central, commissural, or towards one of the three leaflets) and the type of lead-leaflet interaction (leaflet impingement or adhesion) were identified during thorough 2D/3D transthoracic and transesophageal echocardiography examinations. Before and after pTVR, echocardiographic data, including 3D full-volume datasets, were obtained and quantified. TR severity was graded from 1+ to 5+, based upon the effective regurgitant orifice area by the PISA method (EROAPISA) and the vena contracta area (VCA3D) as measured by multiplanar reconstruction from a 3D color Doppler loop. Maximal diastolic tricuspid annulus area from a 3D zoom image, tricuspid tenting area, and right atrial volume were quantified. Right ventricular assessments included ejection fraction (RVEF3D) and diastolic (RVVd3D) and systolic (RVVs3D) volumes. Results Out of 99 patients who underwent pTVR at our hospital, 38 patients had implanted cardiac devices of the following types: pacemakers (n=25, 66%), cardiac defibrillators (n=7, 18%), and biventricular pacemakers (n=6, 16%). In 24 (63%) of these device patients, TR grade was ≤2+ after pTVR. In 14 of the device patients, TR grade remained severe after intervention (Grade 3+ in 15%, grade 4+ in 11%, and Grade 5+ in 11% of the device group). In comparison, in 78% of patients without endocardial leads, only moderate TR was achieved after pTVR. Figure 1 shows the distribution of lead positions within the tricuspid valve. A relevant lead-leaflet interference (rLLI) for pTVR interventions was defined as impingement or adhesion in the target area of the coaptation device (anteroseptal or posteroseptal). Binary logistic regression analysis showed an increase risk (Odds ratio 11, R2 0.34, 95% CI 0.019–0.44, p=0.003) for a suboptimal pTVR result (TR grade >2+ after intervention) in patients with rLLI. Although patients with rLLI (n=17) had significantly higher VCA3D values as compared to patients without rLLI (n=21), it was not predictive for pTVR results. Echocardiographic parameters of right ventricular and tricuspid valve dimensions showed only a trend to higher values in the group with rLLI (Table 1). Conclusion Endocardial lead induced TR negatively impacts the effectiveness of pTVR irrespective of the initial degree of TR. Funding Acknowledgement Type of funding sources: None.

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Goebel, B., C. Salomon, M. Abdulrahman, S. Richter, M. El Garhy, L. Costello-Boerrigter, H. Lapp e P. Lauten. "Impact of endocardial leads on the effectiveness of interventional edge-to-edge repair of tricuspid regurgitation". European Heart Journal - Cardiovascular Imaging 23, Supplement_1 (1 febbraio 2022). http://dx.doi.org/10.1093/ehjci/jeab289.134.

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Abstract Funding Acknowledgements Type of funding sources: None. Background A considerable proportion of patients who are considered for percutaneous tricuspid valve edge-to-edge repair (pTVR) interventions have endocardial lead induced tricuspid regurgitation (TR). The aim of this study was to examine the impact of lead-leaflet interaction on the effectiveness of pTVR. Methods For each patient, the lead position within the tricuspid valve (central, commissural, or towards one of the three leaflets) and the type of lead-leaflet interaction (leaflet impingement or adhesion) were identified during thorough 2D/3D transthoracic and transesophageal echocardiography examinations. Before and after pTVR, echocardiographic data, including 3D full-volume datasets, were obtained and quantified. TR severity was graded from 1+ to 5+, based upon the effective regurgitant orifice area by the PISA method (EROAPISA) and the vena contracta area (VCA3D) as measured by multiplanar reconstruction from a 3D color Doppler loop. Maximal diastolic tricuspid annulus area from a 3D zoom image, tricuspid tenting area, and right atrial volume were quantified. Right ventricular assessments included ejection fraction (RVEF3D) and diastolic (RVVd3D) and systolic (RVVs3D) volumes. Results Out of 99 patients who underwent pTVR at our hospital, 38 patients had implanted cardiac devices of the following types: pacemakers (n = 25, 66%), cardiac defibrillators (n = 7, 18%), and biventricular pacemakers (n = 6, 16%). In 24 (63%) of these device patients, TR grade was ≤2+ after pTVR. In 14 of the device patients, TR grade remained severe after intervention (Grade 3+ in 15%, grade 4+ in 11%, and Grade 5+ in 11% of the device group). In comparison, in 78% of patients without endocardial leads, moderate TR was achieved after pTVR. Figure 1 shows the distribution of lead positions within the tricuspid valve. A relevant lead-leaflet interference (rLLI) for pTVR interventions was defined as impingement or adhesion in the target area of the coaptation device (anteroseptal or posteroseptal). Binary logistic regression analysis showed an increase risk (Odds ratio 11, R2 0.34, 95% CI 0.019-0.44, p = 0.003) for a suboptimal pTVR result (TR grade > 2+ after intervention) in patients with rLLI. Although patients with rLLI (n = 17) had significantly higher VCA3D values as compared to patients without rLLI (n = 21), it was not predictive for pTVR results. Echocardiographic parameters of right ventricular and tricuspid valve dimensions showed only a trend to higher values in the group with rLLI (Table 1). Conclusion Endocardial lead induced TR negatively impacts the effectiveness of pTVR irrespective of the initial degree of TR. Abstract Figure. Abstract Table 1 Echocardiographic parameters

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Vu, Ngoc Tru, e Van Lam Tang. "Studying the effect of the ratio of water to binder and sand to aggregate on the hardness of concrete mixtures and compressive strength of roller-compacted concrete by experimental method". Ministry of Science and Technology, Vietnam online first (29 giugno 2024). http://dx.doi.org/10.31276/vjst.2024.0003.

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In roller-compacted concrete technology, withthe use of low water and cement content, the concrete mixture after kneading has high hardness and compaction equipment must be used to compact and shape the product.Therefore, the content of mixing water, binder, and aggregate are considered decisive factors, greatly affecting the properties of roller compacted concrete in both the fresh state and the hardened state.The paper uses the mathematical method of two-factor rotatable central compositional planning to simulate the effect of volumetric ratios of water-binder (VN/VCKD) and sand-aggregate (VC/VCL) on the objective functions of the test. The selected objective functions are the hardness of the concrete mixture and the compressive strength of the roller-compacted concrete at the age of 28 days.From the obtained objective functions, it is shown that both control variables VN/VCKDand VC/VCLhave a significant influence on the valuesof the experimental model. When the VN/VCKDratio increases, the water content contributes to increasing the plasticityand reducing the hardness of the concrete mixture. At the same time, excess water exists in the concrete mass in the form of air bubbles,pores,and magnetism. That reduces the compressive strength of the product. Furthermore, the VC/VCLratio of the aggregate that is too small or too large tends to cause the compressive strength of the concrete to decrease.

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Pozzi, Ambra, e Raymond C. Harris. "Vanderbilt O'Brien Kidney Center". American Journal of Physiology-Renal Physiology, 28 dicembre 2020. http://dx.doi.org/10.1152/ajprenal.00452.2020.

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The Vanderbilt O'Brien Kidney Center (VOKC) is one of the eight NDDK-P30 funded Centers in the United States. The mission of these core-based Centers is to provide technical and conceptual support to enhance and facilitate research in the field of kidney diseases. The goal of the VOKC is to provide support to understand mechanisms and identify potential therapies for acute and chronic kidney disease. The services provided by the VOKC are meant to help the scientific community to have the right support and tools as well as to select the right animal model, statistical analysis, and clinical study design to perform innovative research and translate discoveries into personalized care to prevent, diagnose and cure kidney disease. To achieve these goals, the VCKD has in place a program to foster collaborative investigation into critical questions of kidney disease; to personalize diagnosis and treatment of kidney disease; and to disseminate information about kidney disease and the benefits of the VOKC services and research. The Center is complemented by state-of-the art Cores and an Education and Outreach program whose goals are to provide an educational platform to enhance the study of kidney disease; to publicize information about services available through the VOKC; and to provide information about kidney disease to patients and other interested members of the community. In this review we highlight the major services and contributions of the VOKC.

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Reference Collection of Annual Meeting 2009.9 (2009): 167–68. http://dx.doi.org/10.1299/jsmemecjsm.2009.9.0_167.

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Journal of the Japan Society for Precision Engineering 75, n. 2 (2009): 249–50. http://dx.doi.org/10.2493/jjspe.75.249.

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