Tesi sul tema "Variation (Genetics)"
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De, Bustos Cecilia. "Genetic and Epigenetic Variation in the Human Genome : Analysis of Phenotypically Normal Individuals and Patients Affected with Brain Tumors". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6629.
Testo completoWalker, Tina Kay. "Genetic variation in schistosomes". Thesis, Brunel University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278245.
Testo completoPandya, Arpita. "Human Y-chromosomal DNA variation". Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298658.
Testo completoKeightley, Peter D. "Studies of quantitative genetic variation". Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/12340.
Testo completoLoh, Yong-Hwee Eddie. "Genetic variation in fast-evolving East African cichlid fishes: an evolutionary perspective". Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41148.
Testo completoRoussos, Athanasios. "Morphological variation, population genetics and genetic relatedness in three species of Callopora". Thesis, Swansea University, 2007. https://cronfa.swan.ac.uk/Record/cronfa42590.
Testo completoGunn, Melissa Rose School of Biological Earth & Environmental Science UNSW. "The use of microsatellites as a surrogate for quantitative trait variation in conservation". Awarded by:University of New South Wales. School of Biological, Earth and Environmental Science, 2003. http://handle.unsw.edu.au/1959.4/22457.
Testo completoRudd, Danielle Song. "Genomic copy number variation in schizophrenia". Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/4739.
Testo completoCotsapas, Chris Biotechnology & Biomolecular Sciences Faculty of Science UNSW. "The genetics of variation in gene expression". Awarded by:University of New South Wales. School of Biotechnology and Biomolecular Sciences, 2005. http://handle.unsw.edu.au/1959.4/30204.
Testo completoBromham, Lindell. "Rate variation in DNA sequence evolution". Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339362.
Testo completoRootsi, Siiri. "Human Y-chromosomal variation in European populations /". Tartu : Tartu University Press, 2004. http://dspace.utlib.ee/dspace/bitstream/10062/1252/5/rootsi.pdf.
Testo completoGoropashnaya, Anna. "Phylogeographic Structure and Genetic Variation in Formica Ants". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3803.
Testo completoEhrenreich, Ian Michael. "The Genetics of Phenotypic Variation in Arabidopsis thaliana". NCSU, 2008. http://www.lib.ncsu.edu/theses/available/etd-08062008-162151/.
Testo completoRussell, Joanne Ritchie. "Molecular variation in Theobroma species". Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386981.
Testo completoMathieson, Iain. "Genes in space : selection, association and variation in spatially structured populations". Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:85f051b6-2121-49cf-9468-3ca7ba77cc4a.
Testo completoGresham, David J. "Genetic variation and disease in the Roma (Gypsies)". Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2001. https://ro.ecu.edu.au/theses/1516.
Testo completoMurtagh, Gareth James. "Sex and variation in lichen-forming fungi". Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285566.
Testo completoArcher, Jason Allan. "Genetic variation in the efficiency of feed utilisation by animals". Title page, table of contents and abstract only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09pha6711.pdf.
Testo completoRogell, Björn. "Genetic variation and local adaptation in peripheral populations of toads". Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107395.
Testo completoElis, Mabon. "Evolutionary genetics of flower colour variation in Antirrhinum". Thesis, University of East Anglia, 2018. https://ueaeprints.uea.ac.uk/69572/.
Testo completoStewart, John E. B. (John Edward Bakos). "Genetic Variation in a Population of the Plains Woodrat Neotoma micropus". Thesis, University of North Texas, 1988. https://digital.library.unt.edu/ark:/67531/metadc500709/.
Testo completoRowell, Jennie Lynn. "GENETIC VARIATION IN THE DOMESTICATED DOG AS A MODEL OF HUMAN DISEASE". The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338237356.
Testo completoHamilton, Katherine Elaine. "Structural and regulatory gene variation in Salmonid fishes". Thesis, Queen's University Belfast, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356872.
Testo completoDe, Winter Gunnar. "The ecology and evolution of individual behavioural variation". Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/44995/.
Testo completoKvernes, Macpherson Carina. "Studying genetics of leaf shape variation in Arabidopsis lyrata". Thesis, Umeå universitet, Institutionen för ekologi, miljö och geovetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-160116.
Testo completoFredman, David. "Computational exploration of human genome variation /". Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-025-7/.
Testo completoPatel, Tulsi. "Investigating genetic variation in Alzheimer's disease". Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52447/.
Testo completoScheet, Paul A. "A flexible and computationally tractable model for patterns of population genetic variation/". Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8932.
Testo completoMarcar, Nico Emile. "Genotypic variation for manganese efficiency in cereals /". Title page, abstract and contents only, 1986. http://web4.library.adelaide.edu.au/theses/09PH/09phm313.pdf.
Testo completoYoung, J. R. "The molecular genetics of antigenic variation in Trypanosoma brucei". Thesis, University of Cambridge, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372285.
Testo completoForsberg, Lena. "Genetic variation and regulation of oxidative stress related genes /". Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4241-2/.
Testo completoSharkey, Andrew M. "Genetic variation in the rodent malaria parasite Plasmodium chabaudi". Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/14391.
Testo completoCardno, Alastair George. "The quantitative genetics of clinical variation in psychotic illnesses". Thesis, Cardiff University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394591.
Testo completoWhiteley, Rachel. "Quantitative and molecular genetic variation in Ulmus laevis Pall. /". Uppsala : Dept. of Plant Biology and Forest Genetics, Swedish Univ. of Agricultural Sciences, 2004. http://epsilon.slu.se/s313.pdf.
Testo completoOchola, Harold Martin Owino. "Using genomics and population genetics to understand genetic variation in Malawi Plasmodium falciparum clinical isolates". Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/15753/.
Testo completoModin, Helena. "Multiple sclerosis : linkage analysis and DNA variation in a complex trait /". Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-792-4/.
Testo completoShringarpure, Suyash. "Statistical Methods for studying Genetic Variation in Populations". Research Showcase @ CMU, 2012. http://repository.cmu.edu/dissertations/117.
Testo completoLee, Peter Daniel. "Building a model for mapping genetic variation affecting gene expression". Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85931.
Testo completoWhittaker, S. L. "Genetics of P. infestans - variation in DNA content and ploidy". Thesis, Bangor University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280024.
Testo completoYue, Wei. "Characterization of genetic variation in secondary metabolites in Fusarium". Diss., Kansas State University, 2017. http://hdl.handle.net/2097/36235.
Testo completoGenetics Interdepartmental Program
Christopher Toomajian
Secondary metabolites (SMs), low molecular weight molecules that are not essential for normal organism growth and development, may confer a selective advantage in some environments. Fungal SMs are structurally and functionally diverse and include mycotoxins, plant regulators and pigments, and the genes that work together in SM biosynthetic pathways are physically clustered in the genome. Fusarium, a genus of filamentous fungi, is noted for SM production, especially mycotoxins, which may contribute to plant pathogenesis. Fusarium species exhibit differences in their SM profiles, and comparative genomics studies have found corresponding differences in the SM gene clusters in some Fusarium species. The investigation of differences in the genomes and SM gene clusters between closely related species, such as F. proliferatum and F. fujikuroi, may help explain their phenotypic divergence, including differences in SM profiles. In addition, the study of intra-species SM variation may indicate how SM loci affect a pathogen’s fitness traits. My research includes three main projects that address different aspects of Fusarium SM variability. To carry out my projects, I established a feasible Genotyping-by-Sequencing (GBS) protocol for Fusarium. One project explored the genetic bases underlying phenotypic divergence related to SM profiles and pathogenicity between F. proliferatum and F. fujikuroi using a quantitative genetics approach. Specifically, I 1) constructed the first high density genetic map based on progeny from an interspecific cross between these two species; and 2) detected a novel regulatory locus for gibberellic acid production and identified a region affecting onion virulence that includes the fumonisin gene cluster. The second project characterized the F. proliferatum parent genome from the previous cross and its SM gene clusters using a comparative genomics approach. Specifically, I 1) assembled the F. proliferatum genome into 12 chromosomes with a combined length of ~43 Mb; 2) annotated this assembly and characterized its 50 SM gene clusters; and 3) detected over 100 F. proliferatum specific genes that might play roles in this species’ host specificity and plant pathogenicity. The third project used a population genomics approach to explore how different F. graminearum chemotypes, or isolates classified based on the accumulation of alternate trichothecene toxin types, may differ for fitness traits and whether trichothecene genes are directly responsible for these differences. Specifically, I 1) genotyped over 300 F. graminearum strains from New York and the upper Midwest in the U.S. and from South America using our GBS protocol; 2) detected two major subpopulations that were correlated, though imperfectly, to the predicted 3-acetyl deoxynivalenol (3ADON) and 15-acetyl deoxynivalenol (15ADON) chemotypes in the U.S.; 3) identified a rapid linkage disequilibrium decay over a few tens of kb followed by a slower decay to background levels over a distance of 200 kb to 400 kb in selected subpopulations in the U.S.; and 4) found that neither chemotype has a clear fitness advantage in a small set of isolates from New York, but that isolates belonging to one genetic subpopulation may on average have a fitness advantage over isolates from the other subpopulation.
Judson, Olivia P. "Parasites, sex and genetic variation in a model metapopulation". Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296922.
Testo completoGoulson, David. "Maintenance of phenotypic variation in the butterfly, Maniola jurtina". Thesis, Oxford Brookes University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293305.
Testo completoSmith, Thomas C. A. "Within genome variation of germ-line and somatic mutation". Thesis, University of Sussex, 2017. http://sro.sussex.ac.uk/id/eprint/68212/.
Testo completoSSEKIMPI, PUPULIO SSEMOMBWE NKUNA ABBY. "CHROMOSOME VARIATION IN DROSOPHILA SPECIES OF THE MULLERI COMPLEX". Diss., The University of Arizona, 1986. http://hdl.handle.net/10150/183809.
Testo completoKing, Rachel, e n/a. "Spatial Structure and Population Genetic Variation in a Eucalypt Species Complex". Griffith University. Australian School of Environmental Studies, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20050113.091713.
Testo completoKing, Rachel. "Spatial Structure and Population Genetic Variation in a Eucalypt Species Complex". Thesis, Griffith University, 2004. http://hdl.handle.net/10072/365496.
Testo completoThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Australian School of Environmental Studies
Full Text
Barrera, Luis A. "Towards a Systematic Approach for Characterizing Regulatory Variation". Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:26718710.
Testo completoBiophysics
Sawyer, Sarah Lynn. "Using SNPs to study complex genetic disease : a population and evolutionary genetics perspective /". Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-967-6/.
Testo completoWahyuni, Wiwiek Sri. "Variation among cucumber mosaic virus (CMV) isolates and their interaction with plants". Title page, contents and summary only, 1992. http://web4.library.adelaide.edu.au/theses/09PH/09phw137.pdf.
Testo completoJohansson, Åsa. "Genome Variation in Human Populations : Exploring the Effects of Demographic History and the Potential for Mapping of Complex Traits". Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7293.
Testo completoA major challenge in human genetics is to understand the genetic variation underlying common diseases. In this thesis, I focus on forces creating differences between individuals and genomic regions, methods for characterizing genomic variation, and the association between genomic and phenotypic variation. Genetic markers are widely used to locate genes associated with different phenotypes. In my first paper, I describe novel algorithms for automatic genotype determination of microsatellite markers, a procedure which is currently both time-consuming and error prone.
The co-segregation of genetic markers in a population leads to non-random association of alleles at different loci - linkage disequilibrium (LD). LD varies throughout the genome and differs between populations due to factors such as their demographic history. In my second paper, I discuss the increased power, for mapping of human traits, that results from studying a population with appreciable levels of LD such as is found in the Swedish Sami population.
Lately, large-scale analyses of single nucleotide polymorphisms (SNPs) have become available and efforts have been made to identify a set of SNPs, which captures most of the genome variation in a population (tagSNPs). In my third paper, I describe the limitations of this approach when applied to data from an independent population sample of randomly ascertained SNPs. The transferability of tagSNPs between populations is poor, presumably due to variation in allele frequencies and the bias towards common SNPs used in most studies.
The level of genomic variation is influenced by population structure, recombination and mutation rate, as well as natural selection. During the exodus from Africa, humans have adapted to new environmental conditions. In my fourth paper, I describe a new method for identifying genomic regions carrying signatures of recent positive selection and apply this to an available dataset of millions of SNPs.