Letteratura scientifica selezionata sul tema "Vaccins à ARN messager"
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Articoli di riviste sul tema "Vaccins à ARN messager"
REYNES, Jacques. "Les vaccins à ARN messager : perspectives en infectiologie". Actualités Pharmaceutiques 62, n. 629 (ottobre 2023): S17—S18. http://dx.doi.org/10.1016/s0515-3700(23)00476-7.
Testo completoREYNES, Jacques. "Les vaccins à ARN messager anti-Covid-19". Actualités Pharmaceutiques 62, n. 629 (ottobre 2023): S11—S16. http://dx.doi.org/10.1016/s0515-3700(23)00475-5.
Testo completoMiauton, Alix, Juliette Besson, Yannick Muller e Blaise Genton. "Vaccins à ARN messager contre le Covid-19 : piqûre de rappel". Revue Médicale Suisse 17, n. 758 (2021): 1910–14. http://dx.doi.org/10.53738/revmed.2021.17.758.1910.
Testo completoDieu-Nosjean, Marie-Caroline, e Jean-Luc Teillaud. "Prix Nobel de physiologie ou médecine 2023 : Katalin Karikó et Drew Weissman". médecine/sciences 40, n. 2 (febbraio 2024): 186–91. http://dx.doi.org/10.1051/medsci/2024002.
Testo completoMarion, O., N. Longlune, M. B. Nogier, C. Gabilan, C. Cartou, B. Seigneuric, A. Del Bello, J. Izopet, S. Faguer e N. Kamar. "Immunogénicité des vaccins à ARN messager chez les dialysés chroniques : une étude monocentrique". Néphrologie & Thérapeutique 17, n. 5 (settembre 2021): 297. http://dx.doi.org/10.1016/j.nephro.2021.07.138.
Testo completoPOUCHAIN, D., R. BOUSSAGEON e E. FERRAT. "DECRYPTER LA NATURE ET LA QUANTITE DES BENEFICES ET DES RISQUES DES VACCINS ARN MESSAGER POUR PREVENIR LA COVID-19". EXERCER 32, n. 170 (1 febbraio 2021): 71–78. http://dx.doi.org/10.56746/exercer.2021.170.71.
Testo completoTangy, Frédéric, e Jean-Nicolas Tournier. "Les virus au service de la santé : la vaccination". médecine/sciences 38, n. 12 (dicembre 2022): 1052–60. http://dx.doi.org/10.1051/medsci/2022168.
Testo completoSahnoun, R., M. Ksentini, R. Athymen, I. Bouaziz, K. Ksouda, H. Affes, L. Ben Mahmoud, S. Hammemi e K. Zghal. "Polysérite après vaccin COVID-19 à ARN messager". Revue Française d'Allergologie 63, n. 3 (aprile 2023): 103509. http://dx.doi.org/10.1016/j.reval.2023.103509.
Testo completoGrunenwald, S., G. Lethellier, P. Imbert, C. Dekeister e P. Caron. "Orbitopathie inflammatoire après vaccin ARN messager anti-SARS-CoV-2". Annales d'Endocrinologie 84, n. 1 (febbraio 2023): 109. http://dx.doi.org/10.1016/j.ando.2022.12.058.
Testo completoBaratali, Laila, e Jean Perdrix. "Vaccin prometteur à ARN messager contre le virus respiratoire syncytial". Revue Médicale Suisse 20, n. 860 (2024): 326. http://dx.doi.org/10.53738/revmed.2024.20.860.326.
Testo completoTesi sul tema "Vaccins à ARN messager"
Sebane, Mohammed Karim. "Développement d’une approche vaccinale antitumorale basée sur la délivrance d’ARN messager". Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ039.
Testo completoImmunotherapy has recently taken on a central role in cancer treatment. Antitumor vaccines stand out as one of the most targeted approaches. Recently, messenger RNA (mRNA) has emerged as a promising vaccine platform, thanks in particular to the development of lipid nanoparticles (LNPs) capable of encapsulating it. However, the latter can induce the appearance of anti-LNP antibodies. Our aim was therefore to develop new vectors for the delivery of mRNA vaccines based on cell-penetrating peptides (CPPs), short peptide sequences capable of crossing cell membranes to deliver therapeutic molecules. This work has led to the identification of CPPs derived from sequences of the antimicrobial peptide LAH4, the viral protein Vpr and hemagglutinin as potential vectors for mRNA delivery to dendritic cells.The CPPs we have developed could represent a viable and efficient alternative for mRNA vectorization, opening up new prospects in the field of antitumor vaccines
Coolen, Anne-Line. "Formulation et vectorisation d’un ARN messager vaccinal codant l’antigène Gag du VIH-1 à l’aide de nanoparticules biodégradables de poly(acide lactique)". Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1292.
Testo completoMRNA-based vaccines currently raise a growing interest in vaccinology. However, the transport and delivery of mRNAs to DC cytoplasm in order to induce antigen production and immune responses remains challenging. The objective of this thesis concerns the design and evaluation of novel strategies to vectorize vaccine mRNAs by poly(lactic acid) nanoparticles (PLA-NPs). We developed a strategy based on mRNA adsorption onto PLA-NPs using, as intermediate, LAH4-L1, an amphipathic cationic peptide. To do this, mRNAs were condensed by LAH4-L1 to form polyplexes which was then adsorbed onto PLA-NPs in a second step to form nanocomplexes. The LAH4-L1/mRNA polyplexes and PLA-NP/LAH4-L1/mRNA nanocomplexes ability to target DCs and induce immune responses in vitro was evaluated. We showed that formulations induce an efficient transfection of mRNA in DCs in vitro. The addition of PLA-NPs in formulations seems to increase sustained expression of mRNAs. DC treatment by inhibitors revealed that polyplexes and nanocomplexes are taken up by phagocytosis and clathrin-dependent endocytosis, and escape endosomes by a v-ATPase-dependent mechanism. Transfection of monocyte-derived DCs (moDCs) showed that LAH4-L1/mRNA polyplexes and PLA-NP/LAH4-L1/mRNA nanocomplexes trigger innate-sensing activation with pro-inflammatory responses. This activation is associated with moDCs maturation, MHC-I and MHC-II presentation, and the secretion cytokines and chemokines involved in adaptive immunity.These data highlight the interest of these new platform formulations to vectorize mRNAs, target DCs and induce immune responses, which in the context of HIV-1, could help the immune system to control the viral load
Gaudin, Cyril. "Nouvelles caractérisations structurales de l'ARN transfert-messager". Rennes 1, 2004. http://www.theses.fr/2004REN10023.
Testo completoAlves, Annabelle. "Analyse fonctionnelle du complexe Nup 107-160 des pores nucléaires au cours du cycle cellulaire des vertébrés". Paris 11, 2005. http://www.theses.fr/2005PA112069.
Testo completoIn eucaryotic cell, nuclear pore complexes (NPCs) allow traffic between nuclear and cytoplasmic compartments. NPCs are large assemblies of proteins, named nucleoporins, that are anchored within the nuclear envelope. During my PhD, I have analyzed the function of a NPC sub-complex, the Nup107-160 complex. The study of this complex using an RNA interference approach in human cells confirmed that this complex has an important role in messengers RNA export in interphase, a feature that might be linked to its appearance in intranuclear foci. In parallel, I have studied the function of the Nup107-160 complex during vertebrate mitosis. I observed that depletion of some components of the Nup107-160 complex by RNA interference induces a decreased staining at the nuclear envelope of numerous nucleoporins and a drastic decrease of NPC number. These data together with in vitro experiments done in collaboration with Dr Mattaj’s laboratory have demonstrated that the Nup107-160 complex plays a critical role during NPC post-mitotic reassembly. Furthermore, the Nup107-160 complex also localizes at kinetochores. We found a potential partner of this complex within these structures. In addition, analysis of the phenotypes induced by Nup107-160 complex depletion at kinetochores show that this complex might be important for proper chromosome segregation during mitosis. The data included in this manuscript have therefore demonstrated that the Nup107-160 complex plays an important role in NPC formation and open new perspectives for the understanding of the mechanisms underlying its involvement in RNA export and chromosome segregation
Hutchison, Stephen. "Caractérisation de deux élements introniques modulant l'épissage alternatif de l'ARN pré-messager du gene de hnRNP A1". Sherbrooke : Université de Sherbrooke, 2001.
Cerca il testo completoRouquier, Sylvie. "La protéine des calculs pancréatiques de rat : structure de l'ARN messager et régulation nutritionnelle". Aix-Marseille 3, 1991. http://www.theses.fr/1991AIX30011.
Testo completoLegendre, Matthieu. "Recherche de motifs d'ARN non-codants : du messager au microARN". Aix-Marseille 2, 2005. http://theses.univ-amu.fr.lama.univ-amu.fr/2005AIX22066.pdf.
Testo completoAzizi, Hiva. "Mechanistic insights of SIDER2 retroposon-mediated mRNA decay in Leishmania". Doctoral thesis, Université Laval, 2017. http://hdl.handle.net/20.500.11794/27725.
Testo completoLeishmania spp. are important human pathogens which put lives of over 350 million people at risk, worldwide. Apart from being an important human pathogen, Leishmania has unique features in terms of gene regulation, rendering it an excellent model organism to study gene regulation mechanisms. Notably, Leishmania and other trypanosomatids lack control at the level of transcription initiation and therefore most of the regulation of gene expression takes place post-transcriptionally. Cis-acting elements in 3ʹ-untranslated regions (3ʹUTRs) of Leishmania messenger RNAs (mRNAs) are central to the regulation of mRNA decay or translation efficiency. We have identified a novel class of cis-acting retroposons, termed SIDERs (Short Interspersed DEgenerate Retroposons) that are widely distributed in the parasite genome (>2000 copies of SIDER1 and SIDER2), mostly within 3ʹUTRs. Transcripts bearing SIDER2 in their 3ʹUTR are degraded via a deadenylation-independent pathway involving endonucleolytic cleavage within the conserved signature II (SII) sequence of SIDER2 elements. My research project aimed at determining the sequence requirements for endonucleolytic cleavage and identifying the trans-acting factor(s) contributing to SIDER2-mediated mRNA decay. We employed a tethering approach using the MS2 system to capture the trans-acting proteins in vivo. Amongst the proteins specifically tethered to SIDER2, the Pumilio protein PUF6 was shown to downregulate the SIDER2-harboring reporter transcript. Furthermore, inactivation of the PUF6 gene resulted in upregulation and increased transcript stability, indicating that PUF6 contributes to SIDER2-mediated decay. Mutational analysis within the conserved SII region, known to regulate decay, highlighted the importance of the previously mapped putative cleavage sites in mediating degradation of SIDER2-containing transcripts. Furthermore, two additional regions closer to the end of the SIDER2 sequence were found to contribute to mRNA destabilization. Finally, we addressed the requirement of translation for SIDER2 mediated decay and showed that degradation of SIDER2 transcripts is linked to ongoing translation, underscoring significance of the translation apparatus in global regulation of SIDER2-containing transcripts.
Rochdi, Moulay Driss. "Les régions 3' non-traduites (3'UTRs) de l'ARNm de la calpastatine : leur organisation, structure et implication dans des intéractions de type ARN-protéine". Sherbrooke : Université de Sherbrooke, 2000.
Cerca il testo completoHerissant, Lucas. "Ubiquitination de l'Histone H2B et Biogenèse des ARN messagers". Paris 7, 2013. http://www.theses.fr/2013PA077222.
Testo completoUbiquitination of histone H2B is a cotranscriptionnal modification which controls nucleosome dynamic and other histones modifications, in particular, methylation on Histone H3. First, I contributed to the analyzis of the regulation of H2B ubiquitination. We showed that the AAA-ATPase Cdc48 facilitates H2B modification by influencing its ubiquitination machinery in the yeast S. Cerevisiae. Then, we investigated the roles of H2B ubiquitination in mRNA biogenesis. We showed that the H2B ubiquitination controls the integrity and stability of the CPF complex, which is involved in 3' end maturation of mRNAs, via its action on the Swd2 protein. This protein facilitates recruitment of nuclear export factors on newly synthetised mRNAs. Thus, H2B ubiquitination allows efficient export of mRNAs from the nucleus to the cytoplasm. In order to determine if H2B ubiquitination is involved in other mRNA maturation steps, we analyzed splicing of all intron-containing genes by specific splicing-arrays as well as the global composition of ribonucleoproteic particules (mRNPs) by mass spectrometry in H2B mutant strain. We observed that H2B ubiquitination promotes splicing of some genes by controlling the recruitment of the early splicing machinery, the snRNPs Ul and U2, on pre¬mRNAs. H2B ubiquitination is thus involved in a crosstalk between transcriptionnal events and mRNP maturation. These results show that the chromatin environnement can affect different essential steps of mRNPs biogenesis in the nucleus
Libri sul tema "Vaccins à ARN messager"
D, Richter Joel, a cura di. mRNA formation and function. San Diego: Academic Press, 1997.
Cerca il testo completoLamond, Angus I. Pre-mRNA processing. New York: Springer-Verlag, 1995.
Cerca il testo completoLamond, Angus I. Pre-mRNA processing. Austin: R.G. Landes Co., 1995.
Cerca il testo completoLemonnier, Jérôme, e Chantal Pichon. Marathon du Messager: Histoire des Vaccins à ARN Messager. EDP Sciences, 2022.
Cerca il testo completoCrisis communication related to vaccine safety: Technical guidance. Pan American Health Organization, 2021. http://dx.doi.org/10.37774/9789275123126.
Testo completoEukaryotic mRNA processing. Oxford: New York, 1997.
Cerca il testo completoCommunicating about Vaccine Safety: Guidelines to help health workers communicate with parents, caregivers, and patients. Pan American Health Organization, 2021. http://dx.doi.org/10.37774/9789275122822.
Testo completoChu, Carolyn, e Christopher M. Bositis. HIV Transmission Prevention. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190493097.003.0004.
Testo completoCapitoli di libri sul tema "Vaccins à ARN messager"
"4 2020 : le triomphe des vaccins à ARNm anti-Covid". In Le marathon du messager, 187–206. EDP Sciences, 2022. http://dx.doi.org/10.1051/978-2-7598-2664-3.c025.
Testo completoNorshira Wan Mohd Ghazali, Wan, Shafizan Mohamed, Soadah Wok e Mohd Helmi Yusoh. "Vaccine Communication and the Media Credibility in Addressing Vaccine Hesitancy: A Focus on Malaysia". In Journalism: The Ethical Dilemma [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108353.
Testo completoTunde Gbonjubola, Yusuff, Daha Garba Muhammad, Nwaezuoke Chisom Anastasia e Tobi Elisha Adekolurejo. "Maximizing COVID-19 Vaccine Acceptance in Developing Countries". In Vaccine Development. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102369.
Testo completoDiers-Lawson, Audra, e Nanna Alida Grit Fredheim. "Designing Strategic Communication Messages for Health in a High Trust Society: Analyzing the Factors Behind Vaccine Confidence in Norway". In Strategic Communication – Contemporary Perspectives, 37–64. Cappelen Damm Akademisk/NOASP, 2024. http://dx.doi.org/10.23865/noasp.208.ch3.
Testo completoDevereux, Paul G., Sarah Y. T. Hartzell e Molly M. Hagen. "Crafting Effective Messages to Encourage COVID-19 Vaccination". In The Social Science of the COVID-19 Pandemic, 182–94. Oxford University PressNew York, 2024. http://dx.doi.org/10.1093/oso/9780197615133.003.0014.
Testo completoCapraro, Valerio, Paulo S. Boggio, Robert Böhm, Matjaž Perc e Hallgeir Sjåstad. "Cooperation and Acting for the Greater Good During the COVID-19 Pandemic". In The Social Science of the COVID-19 Pandemic, 164–81. Oxford University PressNew York, 2024. http://dx.doi.org/10.1093/oso/9780197615133.003.0013.
Testo completoKatika, Afroditi, Emmanouil Zoulias, Vassiliki Koufi e Flora Malamateniou. "Mining Greek Tweets on Long COVID Using Sentiment Analysis and Topic Modeling". In Studies in Health Technology and Informatics. IOS Press, 2023. http://dx.doi.org/10.3233/shti230554.
Testo completoArulmozhiselvan L, Uma E e Jayasri R. "COVID-19: Role of Deep Learning and Cloud Through Identification of Kidney, Pancreas and Intestine". In Advances in Parallel Computing Technologies and Applications. IOS Press, 2021. http://dx.doi.org/10.3233/apc210128.
Testo completoH. Samset, Bjørn. "Styrke og veiledning: Forskningsformidling i møte med særinteresser". In Interessekonflikter i forskning, 231–52. Cappelen Damm Akademisk/NOASP, 2019. http://dx.doi.org/10.23865/noasp.63.ch11.
Testo completoSharif, Salman, e Faridah Amin. "COVID-19 Pandemic; Anxiety and Depression among frontline healthcare workers: Rising from the Ashes". In Anxiety, Uncertainty, and Resilience During the Pandemic Period - Anthropological and Psychological Perspectives [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.98274.
Testo completoAtti di convegni sul tema "Vaccins à ARN messager"
Broadnax, Pier A. "African American Nurse’s Hesitancy to Obtain COVID-19 Vaccinations". In 2nd Annual Faculty Senate Research Conference: Higher Education During Pandemics. AIJR Publisher, 2022. http://dx.doi.org/10.21467/proceedings.135.7.
Testo completoDacumos, Shielanie Soriano. "Lexical Features of Medicine Product Warnings in the Philippines". In 10th International Conference on Computer Networks & Communications (CCNET 2023). Academy and Industry Research Collaboration Center (AIRCC), 2023. http://dx.doi.org/10.5121/csit.2023.130411.
Testo completoDumitran, Angela. "TRANSLATION ERROR IN GOOGLE TRANSLATE FROM ENGLISH INTO ROMANIAN IN TEXTS RELATED TO CORONAVIRUS". In eLSE 2021. ADL Romania, 2021. http://dx.doi.org/10.12753/2066-026x-21-078.
Testo completoRapporti di organizzazioni sul tema "Vaccins à ARN messager"
Lopez Boo, Florencia, Giuliana Daga e Sofia Madariaga. Combating COVID-19 Vaccine Hesitancy: Behaviorally Informed Campaigns in the Caribbean. Inter-American Development Bank, dicembre 2022. http://dx.doi.org/10.18235/0004581.
Testo completoPresseau, Justin, Laura Desveaux, Upton Allen, Trevor Arnason, Judy L. Buchan, Kimberly M. Corace, Vinita Dubey et al. Behavioural Science Principles for Supporting COVID-19 Vaccine Confidence and Uptake Among Ontario Health Care Workers. Ontario COVID-19 Science Advisory Table, marzo 2021. http://dx.doi.org/10.47326/ocsat.2021.02.12.1.0.
Testo completoLippman, Betsy, Rebecca Sutton, Allyson Doby, Zeynep Ilkkursun, Gulsah Kurt, Shaffa Hameed, Ceren Acarturk e Brigitte Rohwerder. Covid-19: Understanding the Impact of the Pandemic on Forcibly Displaced Persons. Institute of Development Studies (IDS), gennaio 2022. http://dx.doi.org/10.19088/cc.2021.010.
Testo completoStall, Nathan M., Kevin A. Brown, Antonina Maltsev, Aaron Jones, Andrew P. Costa, Vanessa Allen, Adalsteinn D. Brown et al. COVID-19 and Ontario’s Long-Term Care Homes. Ontario COVID-19 Science Advisory Table, gennaio 2021. http://dx.doi.org/10.47326/ocsat.2021.02.07.1.0.
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