Bibliografie tematiche / U.S. vs. Germany

Letteratura scientifica selezionata sul tema "U.S. vs. Germany"

Autore: Grafiati

Pubblicato: 26 luglio 2024

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Articoli di riviste sul tema "U.S. vs. Germany"

Giergiel, Sabina. "Ciało, trup, śmierć w utworze Götz i Meyer Davida Albahariego". Slavica Wratislaviensia 168 (18 aprile 2019): 553–64. http://dx.doi.org/10.19195/0137-1150.168.47.

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Body, corpse and death in David Albahari’s Gotz and MeyerThe article investigates the broadly understood record of Jewish death that emerges from the text of the Serbian prose writer David Albahari. Emphasizing the dominance of economy in the Nazi system, the author indicates those procedures described in Albahari’s book which justify such an assessment e.g. human reification, the body as debris, technical syntax used by German officials. Additionally, these considerations on death representation are supplemented with an endeavor to establish the Belgrade dwellers’ attitude towards the fortunes of the Jews. According to the author, the novel explicitly marks the spatial opposition enclosure vs. opening, the camp vs. the city center that is reinforced by the river, which during World War II divided the capital into Zemun belonging to the Independent State of Croatia, also the place where the camp was situated and Belgrade’s Serbian center. This demarcation intensifies the victims’ feelings of separation and loneliness, at the same time enabling the capital’s dwellers to occupy a comfortable position of bystanders. Telo, mrtvac, smrt u romanu Gec i Majer Davida AlbaharijaRad se bavi vidovima smrti u romanu Gec i Majer Davida Albaharija. Pokazuje mehanizme koje potvrđuju opštepoznatu činjenicu da je u nacističkom sistemu dominirala ekonomija. U te mehanizme se ubrajaju, između ostalih: reifikacija čoveka, tretiranje tela kao otpada i tehnička leksika koju upotrebljavaju nemački funkcioneri. Analiza uključuje i pokušaj odgovora na pitanje kakav je bio odnos stanovnika Beograda prema sudbini Jevreja. Istraživanje pokazuje prostornu opoziciju zatvoren i otvoren prostor, logor i centar grada. Nju naglašava reka koja je za vreme Drugog svetskog rata delila srpsku prestonicu na Zemun, gde je bio smešten logor, a koji je pripadao NDH, i srpski centar Beograda. Ova granica je vezana za osećaj separacije i usamljenost žrtava, s jedne starne, i udobnost i bajstander-efekat stanovnika prestonice, s druge strane

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Weirich, Melanie, e Adrian Simpson. "Effects of Gender, Parental Role, and Time on Infant- and Adult-Directed Read and Spontaneous Speech". Journal of Speech, Language, and Hearing Research 62, n. 11 (22 novembre 2019): 4001–14. http://dx.doi.org/10.1044/2019_jslhr-s-19-0047.

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Purpose The study sets out to investigate inter- and intraspeaker variation in German infant-directed speech (IDS) and considers the potential impact that the factors gender, parental involvement, and speech material (read vs. spontaneous speech) may have. In addition, we analyze data from 3 time points prior to and after the birth of the child to examine potential changes in the features of IDS and, particularly also, of adult-directed speech (ADS). Here, the gender identity of a speaker is considered as an additional factor. Method IDS and ADS data from 34 participants (15 mothers, 19 fathers) is gathered by means of a reading and a picture description task. For IDS, 2 recordings were made when the baby was approximately 6 and 9 months old, respectively. For ADS, an additional recording was made before the baby was born. Phonetic analyses comprise mean fundamental frequency (f0), variation in f0, the 1st 2 formants measured in /i: ɛ a u:/, and the vowel space size. Moreover, social and behavioral data were gathered regarding parental involvement and gender identity. Results German IDS is characterized by an increase in mean f0, a larger variation in f0, vowel- and formant-specific differences, and a larger acoustic vowel space. No effect of gender or parental involvement was found. Also, the phonetic features of IDS were found in both spontaneous and read speech. Regarding ADS, changes in vowel space size in some of the fathers and in mean f0 in mothers were found. Conclusion Phonetic features of German IDS are robust with respect to the factors gender, parental involvement, speech material (read vs. spontaneous speech), and time. Some phonetic features of ADS changed within the child's first year depending on gender and parental involvement/gender identity. Thus, further research on IDS needs to address also potential changes in ADS.

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May, Matthias, Philipp Spachmann, Steffen Lebentrau, Harald Schumacher, Christian Gilfrich, Hans-Martin Fritsche, Malte Vetterlein et al. "Fühlen sich Chirurgen gerüstet für die komplexen Fragestellungen im Umgang mit multiresistenten Erregern? – Ergebnisse der Fragebogenstudie MR2". Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie 142, n. 03 (giugno 2017): 297–305. http://dx.doi.org/10.1055/s-0042-120546.

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Zusammenfassung Hintergrund Es liegen derzeit keine Untersuchungen darüber vor, welchen Kenntnisstand Chirurgen im Vergleich mit Nichtchirurgen über multiresistente Erreger (MRE) und den rationalen Einsatz von Antibiotika haben (Antibiotic Stewardship/ABS). Methode Im Rahmen der MR2-Studie (Multiinstitutional Reconnaissance of practice with MultiResistant bacteria – a survey focussing on German hospitals) wurde ein Fragebogen mit 4 + 35 Punkten in 18 deutschen Krankenhäusern an Urologen, Internisten, Gynäkologen und Chirurgen verteilt. Mit multivariaten logistischen Regressionsmodellen wurde der Einfluss der Fachrichtung auf verschiedene prädeterminierte Endpunkte geprüft. Ergebnisse Es konnten 456 auswertbare Fragebögen analysiert werden, wobei sich die Rücklaufquote bei Chirurgen (156/330, 47%) und Nichtchirurgen (300/731, 41%) nur insignifikant unterschied (p = 0,061). Chirurgen gaben in der Selbsteinschätzung im Vergleich mit Nichtchirurgen eine signifikant geringere Sicherheit bei der korrekten Wahl von Dosierung, Frequenz und Dauer der Antibiotikagabe (p = 0,005), der Entscheidung einer intravenösen vs. oralen Antibiotikaverordnung (p = 0,005) sowie der korrekten Interpretation der mikrobiologischen Befunde (p = 0,023) an. Sowohl Chirurgen als auch Nichtchirurgen schätzten ihr Wissen zu ABS als gering ein. Die Kenntnis der lokalen E.-coli-Resistenz gegen Ciprofloxacin unterschied sich zwischen Chirurgen und Nichtchirurgen nur insignifikant (27,6 vs. 35,3% waren in der richtigen Kategorie; p = 0,114), wobei 64% der Chirurgen diese lokalen Resistenzen unterschätzten. Beide Gruppen sahen in dem häufigen Einsatz von Breitspektrumantibiotika ein wesentliches Problem, das für die Zunahme von MRE verantwortlich ist. Andererseits wurde das gewählte Fallbeispiel einer stark symptomatischen Patientin mit unkomplizierter Harnwegsinfektion von beiden Gruppen ähnlich häufig mit einem Breitspektrumantibiotikum behandelt (34,0 vs. 29,3%; p = 0,331). Gemäß der multivariaten Modelle besuchten Chirurgen im Vergleich zu Nichtchirurgen in den letzten 12 Monaten nicht häufiger eine Weiterbildungsveranstaltung zum Thema der MRE/ABS und gaben auch keine bessere Qualität ihrer Klinikepikrisen hinsichtlich der exakten Auflistung von MRE an. Schlussfolgerungen Es sollten in den Kliniken obligat ABS-Programme implementiert werden, die u. a. eine regelmäßige Fortbildung der Kollegen unabhängig von ihrer Fachrichtungen vorsehen.

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Triantafyllias, K., M. Bach, S. Boegel e A. Schwarting. "OP0297 DIAGNOSTIC VALUE OF LABIAL MINOR SALIVARY GLAND BIOPSY IN THE DIAGNOSIS OF SJÖGREN’S SYNDROME: HISTOLOGIC FINDINGS OF 678 BIOPSIES AND ASSOCIATIONS WITH LABORATORY MARKERS, CLINICAL AND PATIENT ASSOCIATED PARAMETERS." Annals of the Rheumatic Diseases 81, Suppl 1 (23 maggio 2022): 197.1–198. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1988.

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BackgroundHistologic findings of salivary gland biopsy are a crucial part of the current ACR-EULAR classification criteria of Sjögren’s cyndrome (SS) (1). Particularly, the finding of a focal lymphocytic sialadenitis (focus score ≥ 1/4 mm2) corresponds to 3 scoring points out of 4 needed to reach a positive classification for SS [1]. Moreover, there is increasing evidence that salivary gland biopsy can provide prognostic information regarding systemic involvement and the development of lymphoma in the context of the disease.ObjectivesThe aim of this study was to analyze the minor labial salivary gland (MLSG) biopsy findings of a large SS cohort and to examine their associations with disease specific laboratory markers, clinical and patient associated parameters.MethodsWe included all patients from two large rheumatological medical departments in Germany having undergone a diagnostic MLSG between 01/2010 and 12/2019. The data have been collected partly in a retrospective and party in a prospective manner. Next to the examination of histological results we focused on activity and chronicity parameters of the underlying disease, autoantibodies, presence of systemic and haematological involvement, as well as on current and previous comorbidities. The statistical analyses included sensitivity and specificity examinations via receiver operating characteristics (ROC), correlation analyses, Mann-Whitney-U-Tests and ANOVA.ResultsIn total, 678 patients have been included (615 ♀, median age 55 years [47-63, IQR]). 306 patients (45.1%) had a positive focus score. The remaining 372 patients with a negative focus score served as a control group. There were significant correlations between the level of the focus score and nicotine use (p=0.002), hypergammaglobulinemia [1.27 (0.71-3.36, IQR) vs. 0.73 (0.0-0.76, IQR); p<0.001], ANA positivity [1.18 (0.11-3, IQR) vs. 0.64 (0-1.34, IQR); p<0.001] and rheumatoid factor positivity (p<0.001). Moreover, focus score levels correlated significantly with disease modifying antirheumatic treatment [1 (0-2.34, IQR) vs. 0.87 (0-1.8, IQR); p=0.004] and weakly significantly with erythrocyte sedimentation rate (r=0.235, p<0.001).Within the group of patients with primary SS there were significant correlations between the level of the focus score and presence of systemic involvement [2 (1.1 - 4, IQR) vs. 1.44 (1-2.62, IQR); p=0.015], glandular involvement [4 (2.98-6.2, IQR) vs. 0.72 (1.6-3, IQR); p=0.007] and haematologic manifestations (p=0.002). SSA-antibodies showed the best diagnostic performance compared to MLSG, as examined by ROC (Table 1).Table 1.Diagnostic value of SSA-antibodies, Sicca, Schirmer´s and Saxon´s test compared to minor labial salivary gland biopsy findings (reference focus score ≥ 1/ 4 mm2)SpecificitySensitivityArea under the curveSSA-Ro antibodies88.2%43.4%0.658Sicca15%91.9%0.535Schirmer´s test27.3%73%0.507Saxons´s test57.9%39%0.541Interestingly enough, among 159 patients who were admitted due to the diagnosis of primary fibromyalgia (FM), 63 (39.6%) could be diagnosed with SS on the basis of histologic findings and the ACR-EULAR classification criteria.ConclusionBy examining one of the largest cohorts in the literature we could show that MLSG biopsy findings not only play a key role in the classification and diagnosis of SS, but could also provide important information regarding the presence of a systemic, glandular or haematological involvement. Furthermore, MLSG can help differentiate patients with FM and other chronic pain disorders from patients with subclinical SS who suffer primarily from chronic pain.References[1]Shiboski CH, et al. International Sjögren’s Syndrome Criteria Working Group. 2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren’s Syndrome. Arthritis Rheumatol. 2017 Jan;69(1):35-45.Disclosure of InterestsNone declared

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Arnold, S., J. Mahrhold, A. Kerstein-Staehle, E. Csernok, B. Hellmich, N. Venhoff, J. Thiel et al. "POS0829 SPECTRUM OF ANCA-SPECIFICITIES IN EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS IN A RETROSPECTIVE MULTICENTER STUDY". Annals of the Rheumatic Diseases 81, Suppl 1 (23 maggio 2022): 705–6. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3083.

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BackgroundAnti-neutrophil cytoplasmic autoantibodies specific for myeloperoxidase (MPO-ANCA) are found in 10-70% of the patients with eosinophilic granulomatosis with polyangiitis (EGPA) depending on disease activity, methodological aspects and cohort examined [1-3]. Recently, a higher prevalence of anti-pentraxin 3 (PTX3)-ANCA has been reported in EGPA compared to granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) [4].ObjectivesTo investigate the spectrum of ANCA specificities in a multicenter cohort of patients with EGPA and identify novel ANCA antigens.MethodsWe conducted a retrospective analysis of 73 patients with EGPA treated between 2015 and 2020 in 3 tertiary referral centers. In addition to in-house ANCA testing with indirect immunofluorescence (IFT) on fixed human granulocytes and antigen-specific enzyme-linked immunosorbent assays (ELISA), ANCA specificities were determined using a cell-based assay (CBA; Euroimmun, Lübeck, Germany). Diagnosis was based on Chapel Hill consensus conference definitions, ACR- and MIRRA-criteria for EGPA. Patient characteristics and clinical manifestations were evaluated and compared based on ANCA status. Fisher`s exact test was employed for comparison of patient groups.ResultsANCA findings are summarized in Table 1. MPO- and proteinase 3 (PR3)-ANCA positive patients (13.7%) had a higher prevalence of peripheral neuropathy (70% vs. 44.4%, p = 0.0003) and glomerulonephritis (20% vs. 14.3%, not significant). MPO- and PR3-ANCA-negative patients (86.3%) had a higher prevalence of heart (10% vs. 46%, p <0.0001), central nervous system (CNS) (0% vs. 14.3%, p <0.0001) and gastrointestinal (10% vs. 22.2%, p = 0.0327) involvement. PTX3-ANCA were associated with a higher prevalence of ear-nose-throat (ENT) (100% vs. 85.3%, p <0.0001), lung (100% vs. 89.7%, p = 0.0015), gastrointestinal involvement (60% vs. 17.6%, p <0.0001) and peripheral neuropathy (100% vs. 48.5%, p <0.0001). Kidney (0% vs. 16.2%, p <0.0001) and CNS involvement (0% vs. 13.2%, p = 0.0002) occurred less frequently in PTX3-ANCA positive patients. The 2 olfactomedin 4 (OLM4)-ANCA positive patients presented with ENT, lung and kidney involvement, and polyneuropathy, respectively.Table 1.ANCA in EGPA cohort (n = 73). BPI = bactericidal permeability-increasing protein.IFT / ELISANo. of patients (%)P-ANCA11 (15.1)C-ANCA5 (6.8)MPO-ANCA8 (10.9)PR3-ANCA2 (2.7)BPI-ANCA1 (1.4)PTX3-ANCA5 (6.8)OLM4-ANCA2 (2.7)ConclusionWe report on the detection of PTX3-, BPI- and OLM4-ANCA in addition to MPO- and PR3-ANCA in EGPA. OLM4-ANCA has been reported in 2 patients with non-vasculitic inflammatory symptoms previously [5]. Herein, detection of OLM4-ANCA in EGPA is reported for the first time. Our study shows that the presence of ANCA with various specificities other than MPO and PR3 contribute to a higher prevalence of ANCA in EGPA. Moreover, clinical manifestations differ between ANCA-negative EGPA and ANCA-positive EGPA, and between patients with different ANCA-specificities.References[1]Schönermarck U, et al. Prevalence and spectrum of rheumatic diseases associated with proteinase 3-antineutrophil cytoplasmic antibodies (ANCA) and myeloperoxidase-ANCA. Rheumatology 2001;40:178-84.[2]Bremer P, et al. Getting rid of MPO-ANCA: a matter of disease subtype. Rheumatology 2013:752-4.[3]Comarmond C, et al. Eosinophilic granulomatosis with polyangiitis (Churg-Strauss): clinical characteristics and long-term followup of the 383 patients enrolled in the French Vasculitis Study Group cohort. Arthritis Rheum 2013;65:270-81.[4]Padoan R, et al. IgG anti-Pentraxin 3 antibodies are a novel biomarker of ANCA-associated vasculitis and better identify patients with eosinophilic granulomatosis with polyangiitis. J Autoimmun 2021;124:102725.[5]Amirbeagi F, et al. Olfactomedin-4 autoantibodies give unusual c-ANCA staining patterns with reactivity to a subpopulation of neutrophils. J Leukoc Biol 2015;97:181-9.Disclosure of InterestsNone declared

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Mai, Stephan, Jens Wilhelmi e Ulrich Barjenbruch. "WAVE HEIGHT DISTRIBUTIONS IN SHALLOW WATERS". Coastal Engineering Proceedings 1, n. 32 (19 gennaio 2011): 63. http://dx.doi.org/10.9753/icce.v32.waves.63.

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In shallow waters the wave height distribution significantly differs from Rayleigh distribution during extreme wind conditions. The EurOtop manual (Pullen et al. 2007) recommends the use of a composite Rayleigh-Weibull distribution proposed by Battjes and Groenendijk (2000) in order to describe the wave statistics in shallow waters. A test of this recommendation by using wave measurements with continuously operated radar level gauges at three different sites at the German North Sea coast for comparison revealed the necessity for a change in the parameterization given in the EurOtop manual. References Barjenbruch, U., S. Mai, N. Ohle, and U. Mertinatis. 2002. Monitoring Water Level, Waves and Ice with Radar Gauges, Proceedings of the Hydro 2002 Conference, DHyG, 328-337. Barjenbruch, U., and J. Wilhelmi. 2008. Application of radar gauges to measure the water level and the sea state, Proceedings of 31st International Conference on Coastal Engineering, ASCE, 687-695. Battjes, J.A., and H.W. Groenendijk. 2000. Wave height distributions on shallow foreshores, Coastal Engineering, 40, 161-182. http://dx.doi.org/10.1016/S0378-3839(00)00007-7 Burcharth, H.F., P. Frigaard, J. Uzcanga, J.M. Berenguer, B.G. Madrigal, and J. Villanueva. 1996. Design of the Ciervana breakwater, Bilbao, Advances in coastal structures and breakwaters, Thomas Telford, London, 26-43. Forristall, G. 2008. Offshore LNG terminal designs must overcome complications of shallow water, Oil & Gas Journal, 106(43). IAHR Working Group on Wave Generation and Analysis. 1989. List of Sea-State Parameters, Journal of Waterway, Port, Coastal and Ocean Engineering, 115(6), pp. 793-80 http://dx.doi.org/10.1061/(ASCE)0733-950X(1989)115:6(793) Klopman, G., and M.J.F. Stive. 1989. Extreme waves and wave loading in shallow water, Proceedings of E&P Forum Workshop: Wave and current kinematics and loading, Paris, Oct. 25-26. Longuet-Higgins, M. S. 1952. On the Statistical Distribution of the Heights of Sea Waves. Journal of Marine Research, 11(3), 245–266. Mai, S. 2008. Statistics of Waves in the Estuaries of the Rivers Ems and Weser - Measurement vs. Numerical Wave Model, Proceedings of the 7th Int. Conf. on Coastal and Port Engineering in Developing Countries COPEDEC, CD-ROM. Nelson, R.C. 1994. Depth limited design wave heights in very flat regions, Coastal Engineering, 23, 43-59. http://dx.doi.org/10.1016/0378-3839(94)90014-0 Pullen, T., N.W.H. Allsop, T. Bruce, A. Kortenhaus, H. Schüttrumpf, and J.W. van der Meer. 2007. EurOtop – Wave Overtopping of Sea Defences and Related Structures: Assessment Manual, Die Küste, 73, 193 pp. (online:

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Korte, Wolfgang, e Jeanette Greiner. "Variables Influencing the the Protein C Pathway Response in Children with ALL." Blood 114, n. 22 (20 novembre 2009): 2986. http://dx.doi.org/10.1182/blood.v114.22.2986.2986.

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Abstract Abstract 2986 Poster Board II-962 Introduction: The protein C pathway is believed to be a crucial regulator of coagulation. Similar to the adult population, it is of utmost importance in pediatric patients to maintain the balance between pro- and anticoagulatory signals (Petaja and Manco-Johnson 2003). Cancer patients have been shown to have cancer and cancer-therapy associated pathologies of the protein C pathway. (Nijziel, van Oerle et al. 2003; Woodley-Cook, Shin et al. 2006). A test evaluating the response of the protein C pathway after activation of endogenous protein C has been shown to be a sensitive tool to screen for protein C deficiency and APC resistance whereas protein S deficiency is detected less reliably (Toulon, Halbmeyer et al. 2000). This is in line with findings suggesting that any pathology of this assay is related to an increased risk of VTE, independent of the pathology related to the abnormality of the test result (Toulon, Perez et al. 2007). Similarly, patients with idiopathic pregnancy loss were found to have a pathological response independent of the pathology related (Sarig, Lanir et al. 2002). Methods: We therefore evaluated the influence of different variables on the results of the global protein C assay (Pro C Global on a BCS analyzer, Siemens, Marburg, Germany) in 431 children enrolled into the Thrombotect study. The Thrombotect study is a prospective, randomized trial evaluating unfractionated heparin vs low molecular weight heparin vs antithrombin replacement for prevention of thromboembolism in children undergoing asparaginase containing chemotherapy for acute lymphoblasic leukaemia within the BFM protocol. A multivariate linear regression analysis on results obtained before treatment was performed (MedCalc 10.0.1). Results: To date (as of 8/09), 720 children have been randomized in the Thrombotect trial. At the time, we had complete data for laboratory evaluation available for 431 children on day 0 of the treatment protocol. Free protein S, IgG antibodies against cardiolipin or phosphatidlyserine, dRVVT, fibrinogen, the presence of F II G20210A, homocystein concentration, Lp(a) concentration and PAI-1 activity had no predictive value towards the protein C pathway assay result in this multivariate analysis. In contrast, the protein C pathway activity was expectedly shown to be dependent on the presence of the F V Leiden mutation (p<0.0001), protein C activity (p<0.0001) and F VIIIc (p=0.0001). Unexpectedly, the protein C pathway activity was also dependent on antithrombin activity (p=0.0166), F XIIc (p=0.0137) and IgM (but not IgG) antibodies against cardiolipin (p=0.0304) and phosphatidylserine (p=0.0006) in this multivariate analysis. Importantly, the association between protein C pathway activity and the “unexpected” predictors were independent of whether or not the results were in the reference range or not (median [95% CI] antithrombin activity 0.95 [0.93-0.97], median F XIIc 0.94 [0.90-0.98], median ACL IgM 2 [2-3] U/ml, median APS IgM 2 [2-3] U/ml). Conclusions: The protein C pathway is believed to be a crucial regulatory element of haemostasis. Our results from a large cohort (n = 431) of children with ALL and thus at risk for thromboembolism indicate that the protein C pathway is -expectedly (such as F V Leiden mutation, protein C activity, F VIIIc) and unexpectedly (such as antithrombin activity and the concentration of antiphospholipid IgM antibodies) - interdependent with many other variables of the coagulation system. These data provide evidence that the protein C pathway ex vivo in children with ALL is targeted by various elements of other haemostasis pathways in a significant manner in multivariate analysis. Disclosures: No relevant conflicts of interest to declare.

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Iaremenko, O., e G. Mykytenko. "AB0177 ASSOCIATION OF SEROLOGICAL STATUS WITH THE FREQUENCY OF CLINICAL AND RADIOLOGICAL REMISSION IN RHEUMATOID ARTHRITIS". Annals of the Rheumatic Diseases 81, Suppl 1 (23 maggio 2022): 1218.1–1218. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2297.

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BackgroundAchieving remission is one of the main goal in the management of patients (pts) with rheumatoid arthritis (RA). According to the literature, one of the determining predictor of the disease course is the serological variant of RA [1]. However, there are conflicting data in scientific publications concerning relationship between the presence/titre of antibodies to cyclic citrullinated peptide (ACCP) or rheumatoid factor (RF) and the frequency/rate of remission [1].ObjectivesTo examine associations of ACCP- and RF-status with possibility and timing of clinical and radiological remission in Ukrainian pts with RA while taking the main non-biological disease modifying anti-rheumatic drugs (DMARD).MethodsIn enrolled pts RF titer was determined by the latex agglutination method (Humatex, Germany), reference values <20 IU/ml; ACCP level - by ELISA (IBL-Hamburg, Germany), the diagnostic limit of ACCP was ≥15U/ml, the maximum value ≥ 345U/ml. All pts received non-biological DMARD: methotrexate, leflunomide, sulfasalazine or its combination with hydroxychloroquine. At baseline and after 6, 12 and 24 months (mth) of treatment the disease activity and achievement of remission (by DAS28; Sharpe-van der Heide scale) in different subgroups of RA pts were analysed.Results128 pts with RA were included in the study; the mean (SD) age was 54 (12.7) years and follow-up was for 2.0 (1.3) years. Most were women (72.4%), mean disease duration 18.4± 3.18 mth. ACCP-positive were 64.8% and RF - 57.1% pts. According to serological status at baseline, pts were stratified into four classes: ACCP+RF- (n=19), RF+ACCP- (n=9), dual positive (n=64) and dual negative (n=36). There were no significant differences between the analysed groups in age, sex, RA duration, disease activity, radiological changes and prescribed therapy (p>0.05).During the 2-year follow-up, clinical remission was achieved in a total of 27 (21.1%) pts, including early remission (during first 6 mth) in 25 (19.5%). The percentage of pts in remission were 36.1, 33.3, 15.8, and 12.5 respectively for RF−/ACCP−, ACCP−/RF+, ACCP+/RF−, and ACCP+/RF+ (χ2 = 7.74, p<0.05 RF−/ACCP− vs ACCP+/RF+; χ2 = 4.55, p <0.05 ACCP−/RF+ vs ACCP+/RF+). The rate of remission (frequency of early remission in the structure of general remission) in four analysed groups did not differ significantly and was 75%, 66.6%, 66.6% and 84.6%, respectively. The ACCP titer in pts who achieved and didn’t achieve remission were respectively 240.8 ± 38.5 U / ml and 187.8 ± 13.7 U / ml, p>0.05. There also wasn’t difference between RF titer and the frequency of remission in these groups (257.9±233.8 IU / ml vs 293.2±257.3 IU / ml, p> 0.05). According to our data, there was no correlation between the level of RF / ACCP and the frequency of remission.Radiological remission was achieved in 46.7% of ACCP-negative patients and only in 10.6% of ACCP-positive patients (p <0.01). The absence of RF in the blood was also associated with a more frequent achievement of radiological remission (in 34.2% of pts) compared with the RF-positive cohort of pts (in 15.4%, p <0.05). Double seronegative pts achieved remission three times more often (48.1% pts) than double seropositive (13.9%, p<0.01).ConclusionOur data suggest that the frequency of clinical remission, including early, is three times higher in patients with RA, negative for ACCP. The rate of clinical remission (ratio of early in the structure of the general) doesn’t depend on the serological variant of RA: about two thirds of pts in all analysed groups achieve remission in the first 6 mth of DMARD therapy. ACCP- and RF-titers in the onset of the disease don’t influence on the possibility of achieving clinical and radiological remission. Radiological remission is observed three times more often in seronegative (for ACCP or RF) pts. Double seropositivity has an additive effect on subsequent joint destruction.References[1]Yilmaz-Oner S. et al. Predictors and the optimal duration of sustained remission in rheumatoid arthritis. Clin Rheum. 2019;38(11):3033-3039.Disclosure of InterestsNone declared

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Smyser, W. R. "U. S. S. R.-Germany: A Link Restored". Foreign Policy, n. 84 (1991): 125. http://dx.doi.org/10.2307/1148786.

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Меліса Грабовач e Капранов Олександр. "Syntactic Complexity at the Intermediate Level in EFL Writing by Early Balanced Bilinguals". East European Journal of Psycholinguistics 3, n. 1 (30 giugno 2016): 55–64. http://dx.doi.org/10.29038/eejpl.2016.3.1.gra.

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The present article involves an empirical psycholinguistic study aimed at examining syntactic complexity in English as a Foreign Language (EFL) by early balanced Bosnian/Swedish bilingual EFL learners. 15 early balanced bilingual Bosnian/Swedish EFL learners were recruited for the study and matched with their respective control groups of intermediate EFL learners (15 speakers of Bosnian as their first language (L1) and 15 speakers of Swedish as their L1). The experimental task involved an unprepared writing assignment in English about the most significant invention of the 20th century. The corpus of the participants’ written assignments was analysed in L2 Syntactic Complexity Analyzer and SPSS software programs respectively. Data analysis involved measures of syntactical complexity. It has been found that the participants’ written assignments are characterised by statistically significant number of T-units scores in comparison with the Swedish L1 monolingual controls. These findings are further presented and discussed in the article. References Ahmadian, M. J., & Tavakoli, M. (2011). The effects of simultaneous use of careful onlineplanning and task repetition on accuracy, complexity, and fluency in EFL learners’ oralproduction. Language Teaching Research, 15(1), 35-59. Alotaibi, A. M. (2016). Examining the Learnability of English Relative Clauses: Evidencefrom Kuwaiti EFL Learners. English Language Teaching, 9(2), 57. Bardovi-Harlig, K., & Bofman, T. (1989). Attainment of syntactic and morphologicalaccuracy by advanced language learners. Studies in Second Language Acquisition, 11(01),17-34. Byrnes, H. (2009). Emergent L2 German writing ability in a curricular context: Alongitudinal study of grammatical metaphor. Linguistics and Education, 20(1), 50–66. Ben-Zeev, S. (1977). The influence of bilingualism on cognitive strategy and cognitivedevelopment. Child Development, 48(3), 1009–1018. Bialystok, E. (1988). Levels of bilingualism and levels of linguistic awareness.Developmental Psychology, 24, 560–567. Bialystok, E., Majumder, S., & Martin, M.M. (2003). Developing phonological awareness:Is there a bilingual advantage? Applied Psycholinguistics, 24, 27–44. Cenoz, J. (1998). Beyond bilingualism: multilingualism and multilingual education.Clevedon, England Multilingual Matters Cenoz, J. & Valencia, J. (1992). The role of bilingualism in foreign language acquisition:Learning English in the Basque country. Journal of Multilingual and MulticulturalDevelopment Cummins, J. (2000). Language, Power, and Pedagogy: Bilingual Children in theCrossfire. Clevedon, England: Multilingual Matters Daiute, C.A. (1981). Psycholinguistic Foundations of the Writing Process. Research in theTeaching of English, 15, 1, 5–22 Dekydtspotter, L., & Renaud, C. (2014). On second language processing and grammaticaldevelopment: The parser in second language acquisition. Linguistic Approaches toBilingualism, 4(2), 131–165. Gaies, S. J. (1979). Linguistic input in formal second language learning: The issues ofsyntactic gradation and readability in ESL materials. TESOL quarterly, 41–50. Gaies, S. J. (1980). T-unit analysis in second language research: Applications, problemsand limitations. TESOL quarterly, 53–60. Grodner, D., Gibson, E., & Tunstall, S. (2002). Syntactic complexity in ambiguityresolution. Journal of Memory and Language, 46(2), 267–295. Grosjean, F. (2008). Studying Bilinguals. Journal of linguistics, 45, 3, 715–719. Herdina, P, & Jessner U. (2000). The dynamics of third language acquisition. In J. Cenozand U. Jessner (eds) English in Europe: The Acquisition of a Third Language, (pp. 84–98).Clevedon: Multilingual Matters. Ho-Peng, L. (1983). Using T-unit measures to assess writing proficiency of university ESLstudents. RELC Journal, 14(2), 35–43. Hunt, K. (1965). Grammatical structures written at three grade levels. NCTE Researchreport, 3. Champaign, IL. Hunt, K. W. (1970). Syntactic maturity in schoolchildren and adults. Monographs of thesociety for research in child development, 35(1), iii–67. Inoue, C. (2016). A comparative study of the variables used to measure syntacticcomplexity and accuracy in task-based research. The Language Learning Journal, 1–19. Iwashita, N. (2006). Syntactic complexity measures and their relation to oral proficiency inJapanese as a foreign language. Language Assessment Quarterly: An InternationalJournal, 3(2), 151–169. Kapranov, O. (2015). Self-Evaluation of Speech Fluency in English as a Second Languageby Korean Exchange Students Studying in Sweden. In L. Szymanski & M. Kuczynski(eds.) Language, Thought and Education: Exploring Networks. (pp. 61–77). Zielona Gora:Oficyna Wydawnicza Uniwersytetu Zielenogorskiego. Kapranov, O. (2013). Beginner Students’ Speech Fluency in a Second LanguageCompared across Two Contexts of Acquisition. In E. Piechurska-Kuciel & E. SzymanskaCzaplak (eds.) Language in Cognition and Affect (pp.81-95). Berlin: Springer. Kobayashi, H., & Rinnert, C. (1992). Effects of First Language on Second LanguageWriting: Translation versus Direct Composition. Language Learning, 42(2), 183–209. Lambert, W.E. (1974). Culture and language as factors in learning and education. Culturalfactors in learning and education. Bellingham, WA: Fifth Western WashingtonSymposium on Learning. Lu, X. (2010). Automatic analysis of syntactic complexity in second language writing,International Journal of Corpus Linguistics, 15(4), 474–496. Macnamara, B. N., & Conway, A. R. (2014). Novel evidence in support of the bilingualadvantage: Influences of task demands and experience on cognitive control and workingmemory. Psychonomic bulletin & review, 21(2), 520–525. Molnár, T. (2011). Second language versus third language acquisition: A comparison ofthe English lexical competence of monolingual and bilingual students. Toronto WorkingPapers in Linguistics, 33(1). Navés, T., Torras, M. R., & Celaya, M. L. (2003). Long-term effects of an earlier start: Ananalysis of EFL written production. Eurosla yearbook, 3(1), 103–129. Norbert, F. (2012). Bilingual competence and bilingual proficiency in child development.Massachusetts: MIT Press. Ortega, L. (2003). Syntactic complexity measures and their relationship to L2 proficiency:A research synthesis of college‐level L2 writing. Applied linguistics, 24(4), 492–518. Shaw, P., & Liu, E. T. K. (1998). What develops in the development of second-languagewriting?. Applied linguistics, 19(2), 225–254. Slavoff, G.R. & Johnson, J. S. (1995). The effects of age and the rate of learning a secondanguage. Studies in Second Language Acquisition, 17 (1), 1–16. Sotillo, S. M. (2000). Discourse functions and syntactic complexity in synchronous andasynchronous communication. Language Learning & Technology, 4(1), 82–119. Weissberg, B. (2000). Developmental relationships in the acquisition of English syntax:writing vs. speech. Learning and Instruction 10, 37–53. Wolfe-Quintero, K., Inagaki, S, & Kim, H-Y. (1998). Second Language Development inWriting: Measures of Fluency, Accuracy and Complexity Honolulu: University of Hawai'i,Second Language Teaching and Curriculum Center. Wolff, D. (2000). Second language writing: a few remarks on psycholinguistic andinstructional issues. Bergische Universita¨t Gesamthochschule Wuppertal: Wuppertal,Germany. Xiaofei, L. (2010). L2 Syntactical Complexity Analyzer. Software program. Yau, M. S., & Belanger, J. (1984). The Influence Mode on the Syntactic Complexity ofEFL Students at Three Grade Levels. TESL Canada Journal, 2(1), 65–77. Youn, S. J. (2014). Measuring syntactic complexity in L2 pragmatic production:Investigating relationships among pragmatics, grammar, and proficiency. System, 42, 270–287.

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Tesi sul tema "U.S. vs. Germany"

LIN, CHIH SHARN, e 池祥麟. "A COMPARATIVE STUDY ON GOVERNMENT BOND FUTURES CONTRACTS IN U. S., JAPAN, GERMANY, FRANCE, AND U.K.：COMMENTS ON TAIWAN GOVERNMENT BOND FUTURES CONTRACTS．". Thesis, 1993. http://ndltd.ncl.edu.tw/handle/33530117050750570029.

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Bonneau, Éric. "Études structurales par résonance magnétique nucléaire du ribozyme VS de Neurospora". Thèse, 2015. http://hdl.handle.net/1866/12305.

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Le ribozyme VS de Neurospora catalyse des réactions de clivage et de ligation d’un lien phosphodiester spécifique essentielles à son cycle de réplication. Il est formé de six régions hélicales (I à VI), qui se divisent en deux domaines, soit le substrat (SLI) et le domaine catalytique (tiges II à VI). Ce dernier comprend deux jonctions à trois voies qui permettent de reconnaître le substrat en tige-boucle de façon spécifique. Ce mode de reconnaissance unique pourrait être exploité pour cibler des ARN repliés pour diverses applications. Bien que le ribozyme VS ait été caractérisé biochimiquement de façon exhaustive, aucune structure à haute résolution du ribozyme complet n’a encore été publiée, ce qui limite la compréhension des mécanismes inhérents à son fonctionnement. Précédemment, une approche de divide-and-conquer a été initiée afin d’étudier la structure des sous-domaines importants du ribozyme VS par spectroscopie de résonance magnétique nucléaire (RMN) mais doit être complétée. Dans le cadre de cette thèse, les structures de la boucle A730 et des jonctions III-IV-V et II-III-VI ont été déterminées par spectroscopie RMN hétéronucléaire. De plus, une approche de spectroscopie RMN a été développée pour la localisation des ions divalents, tandis que diverses approches de marquage isotopique ont été implémentées pour l’étude d’ARN de plus grandes tailles. Les structures RMN de la boucle A730 et des deux jonctions à trois voies révèlent que ces sous-domaines sont bien définis, qu’ils sont formés de plusieurs éléments structuraux récurrents (U-turn, S-turn, triplets de bases et empilement coaxial) et qu’ils contiennent plusieurs sites de liaison de métaux. En outre, un modèle du site actif du ribozyme VS a été construit sur la base des similarités identifiées entre les sites actifs des ribozymes VS et hairpin. Dans l’ensemble, ces études contribuent de façon significative à la compréhension de l’architecture globale du ribozyme VS. De plus, elles permettront de construire un modèle à haute résolution du ribozyme VS tout en favorisant de futures études d’ingénierie.
The Neurospora VS ribozyme catalyzes the cleavage and the ligation of a specific phosphodiester bond, which is essential for its replication cycle. It is formed of six helical regions (I to VI) that are divided in two domains: the substrate (SLI) and the catalytic domain (stems II-VI). The latter contains two three-way junctions that allow recognition of the stem-loop substrate in a specific manner. This unique mode of substrate recognition could be exploited to target folded RNAs for diverse applications. Even though the VS ribozyme has been extensively characterized biochemically, no high-resolution structure of the complete ribozyme has been published yet and this limits our mechanistic understanding. A divide-and-conquer approach was previously initiated to study the structure of the important subdomains of the VS ribozyme by nuclear magnetic resonance (NMR), but this approach needs to be completed. In this thesis, the structures of the A730 loop, the III-IV-V junction and the II-III-VI junction were determined by heteronuclear NMR spectroscopy. Moreover, a unique NMR approach was developed for localizing divalent metal ions, whereas several isotope-labeling strategies were implemented to facilitate the study or large RNA molecules. The NMR structures of the A730 loop and the two three-way junctions reveal that these subdomains are well defined, that they are formed by several recurrent structural elements (U-turn and S-turn motifs, base triples and coaxial stacking) and that they contain several metal-binding sites. Interestingly, structural similarities were identified between the VS and hairpin ribozymes, which allowed the modeling of the VS ribozyme active site. In summary, these studies significantly contribute to a better understanding of the global architecture of the VS ribozyme. In addition, they will allow the construction of a high-resolution model of the complete VS ribozyme and facilitate future engineering studies.

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Libri sul tema "U.S. vs. Germany"

Association, Light Rail Transit, e Arbeitsgemeinschaft Blickpunkt Strassenbahn, a cura di. Tramway & light railway atlas Germany 1996: Tramway, U-Bahn, S-Bahn, trolleybus. Berlin: Arbeitsgemeinschaft Blickpunkt Straßenbahn, 1995.

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Peterson, Megan Cooley, Matt Chandler e Carol Kim. Fact vs. Fiction in U. S. History. Capstone, 2021.

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Peterson, Megan Cooley, Matt Chandler e Carol Kim. Fact vs. Fiction in U. S. History. Capstone, 2023.

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Peterson, Megan Cooley, Matt Chandler e Carol Kim. Fact vs. Fiction in U. S. History. Capstone, 2021.

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Peterson, Megan Cooley, Matt Chandler e Carol Kim. Fact vs. Fiction in U. S. History. Capstone, 2021.

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Peterson, Megan Cooley, Matt Chandler e Carol Kim. Fact vs. Fiction in U. S. History. Capstone, 2023.

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Stone, Melanie, e Jeremy Stone. Trump Returns For 2025!: The U. S. vs China. Independently Published, 2021.

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Sharp, D. U. S. Midterm Election Results: 2018 vs. 2016 Turnout. Independently Published, 2019.

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Livingston, Robert Gerald, Martin J. Hillenbrand, Uwe Thaysen e Nelson W. Polsby. U. S. Congress and the German Bundestag. Taylor & Francis Group, 2019.

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J, Nelson Daniel. History of U. S. Military Forces in Germany. Taylor & Francis Group, 2019.

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Ettlie, John E., e Peter Swan. "U .S.-Japanese Manufacturing Joint Ventures and Equity Relationships". In Engineered In Japan, 278–308. Oxford University PressNew York, NY, 1995. http://dx.doi.org/10.1093/oso/9780195095555.003.0012.

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Abstract Recent headlines read “GM to Sell Its 50% Stake in GMF annual, a Robotics Firm, to Japanese Partner” (Wall Street Journal, June 4, 1992, Business Briefs section) and “IBM, Toshiba, Siemens to Team Up” (Ann Arbor News, July 13, 1992). The dissolution and formation of joint ventures (]Vs) in manufacturing continue to be high drama in the world competitive scene, but the reasons for formation and dissolution of these ventures are still not well understood.

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Abraham, David. "Circumcision. Muslims, Jews, and Constitutional Identity in Germany and the U. S." In Wer gehört zu uns?, 135–57. Wallstein Verlag, 2019. http://dx.doi.org/10.5771/9783835343290-135.

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Doraiswamy, L. K. "Rates and Equilibria in Organic Reactions : The Thermodynamic and Extrathermodynamic Approaches". In Organic Synthesis Engineering. Oxford University Press, 2001. http://dx.doi.org/10.1093/oso/9780195096897.003.0007.

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In any reversible reaction such as . . . vA A + vB B ↔ vR R + vS S [2.1] . . . the system inevitably moves toward a state of equilibrium, or maximum probability. This equilibrium state is very important in analyzing chemical reactions because it defines the limit to which any reaction can proceed. Organic reactions, particularly those constituting a synthetic scheme for a fine chemical, usually involve molecules reacting in the liquid phase. The effects of reactant structure and of the solvent (medium) in which the reaction occurs (the solvation effects) are not included in the conventional macroscopic approach to thermodynamics. Therefore, the treatment of liquid-phase reactions tends to be less exact than that of gas-phase reactions involving simpler molecules without these influences. A convenient way of approaching this problem is to start with the conventional macroscopic or thermodynamic approach and add enough microscopic detail to allow for the effects of solute (reactant) structure and the medium. This approach is called the extrathermodynamic approach and may be regarded as bridging the gap between the two rather disparate fields of rates and equilibria represented by kinetics and thermodynamics, respectively. Such an approach is particularly useful in organic synthesis and forms the subject matter of this chapter. An important consideration in process calculations is the change that results in the basic thermodynamic properties, internal energy (U), enthalpy (H), Helmholtz work function (A), and Gibbs free energy (G) when a closed system of constant mass moves from one macroscopic state to another. For a homogeneous fluid, these change equations can be expressed in terms of four differential equations, which then can be written in difference form by employing the operator Δ to represent the change from state 1 to state 2: Of these, the enthalpy and free energy change equations are the most frequently used in the analysis of reactions.

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STRZELBICKI, JERZY, BOZENA STRZELBICKA, KARL SCHÜGERL e RICHARD A. BARTSCH. "Crown Ethers in Separation of Alkali Metal Cations1 1This Research Was Supported By The Division Of Chemical Sciences Of The Office Of Basic Energy Sciences Of The U. S. Department Of Energy (For J.S., B.S. And R.A.B.) And By The Alexander Von Humboldt Foundation (West Germany) (Fellowship For J.S.)." In Solvent Extraction 1990, Part B, 1523–28. Elsevier, 1992. http://dx.doi.org/10.1016/b978-0-444-88677-4.50070-2.

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STRZELBICKI, JERZY, BOZENA STRZELBICKA, ELZBIETA LUBBOCH e RICHARD A. BARTSCH. "Separation of Alkali Metal Cations by Polymer-Supported Liquid Membranes Using Ionizable Crown Ethers12 1This Paper Was Presented At The Isec'90 By Prof. Dr. Karl SchÜGerl Of The Institute Of Technical Chemistry, University Of Hannover (West Germany). 2This Research Was Supported By The Division Of Chemical Sciences Of The Office Of Basic Energy Sciences Of The U. S. Department Of Energy." In Solvent Extraction 1990, Part B, 1517–22. Elsevier, 1992. http://dx.doi.org/10.1016/b978-0-444-88677-4.50069-6.

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"Both opponents and proponents of food irradiation have been sources of misinformation or valid information presented in a misleading way (20). As described by a leading British consumer representative: “ The battle to get irradiation of food accepted as a beneficial food processing technique has been waged for some 30 years. It is an interesting case of warring factions glaring at each other across a gulf of incomprehension” ( ). In this book an attempt will be made to provide factual data as a basis for a more rational approach to these controversies. The seminar jointly held by IOCU (International Organization of Consumer Unions) and ICGFI (International Con sultative Group on Food Irradiation) in 1993 (22) has raised hopes that this gulf of incomprehension can be narrowed, perhaps even closed. There is voluminous scientific literature on food irradiation, but it is not easy to come by because contributions have come from so many disciplines. Relevant reports have been published in journals of food technology, nutrition, microbiol ogy, analytical chemistry, food chemistry, radiation chemistry, radiation physics, toxicology, health physics, and other fields. There is only one scientific journal devoted exclusively to food irradiation research: Shokuhin-Shosha (Food Irradia tion, Japan), published by the Japanese Research Association for Food Irradiation since 1965; articles are in Japanese, with English abstracts. In order to facilitate access to this literature a computerized irradiation information database called IRREFCO (Irradiation Reference Collection) has been installed at the National Agricultural Library in the United States. It is initially aimed at making available the research contract reports generated in programs sponsored by the U. S. Army and U. S. Atomic Energy Commission in the 1950s and 1960s. Those reports are not accessible through ordinary library services. A selected annotated bibliogra phy is offered since 1993 (23). A bibliography on food irradiation has been prepared since 1955 by the Federal Research Center for Nutrition, Karlsruhe, Germany; it now contains over 10,000 documents. The whole database is pro cessed and stored on computer, and is also available in printed form. In recent years one issue of the printed bibliography has been published annually, each with 300-600 references (24). In the following chapters only a small fraction of these documents can be mentioned. The author endeavors to quote primarily those studies that will guide the reader to key issues, to review articles, and to other works showing a path to the remaining literature. Useful documentation of developments in food irradiation research can be found in three newsletters. Food Irradiation Quarterly International Newsletter (Saclay) was published in English and French by the European Information Center for Food Irradiation, Saclay, France, from 1960 to 1971. The International Project in the Field of Food Irradiation issued Food Irradiation Information (Karlsruhe) from 1972 until 1982. The Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency, has Published Food Irradiation Newsletter (Vienna) since 1976." In Safety of Irradiated Foods, 24–26. CRC Press, 1995. http://dx.doi.org/10.1201/9781482273168-18.

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"Both types of RhnuN cells (amorph and regulator types) lacked the Rh proteins and other proteins, and showed some functional abnormalities. No Rh glycoprotein is immune precipitated by anti-D but it is present in membranes from some RhnuNs as shown by immunoblotting studies with the monoclonal antibody MB-2D10 [30]. The LW protein is missing and some other antibodies only react weakly: anti-U, Duclos, anti-FY5, BRIC 125 (anti-CD47) and the monoclonal antibody 1D8. That so many determinants encoded by genetically independent loci are not fully expressed in RhnuN cells has led to the idea of a protein complex or cluster which involves the Rh proteins, Rh glycoproteins and other proteins [31,32,33]. Since D and CE proteins are integral proteins with about 12 transmembrane domains, it is hypothesised that they and the other proteins interact, perhaps affecting insertion into the membrane. Some of the variation observed in Rh antigens may not depend on mutations in the Rh genes but may reflect alterations in other proteins of the Rh protein complex. D , the most important antigen, has been exhaustively studied. Quantitative and qualitative variation of D is well documented [see 34]. Several other Rh antigens show quantitative and qualitative variation. We have observed variation in C, E, c, e, G, V, VS, Rh17 and Rh29 antigens. Possibly it is a common finding for Rh antigens. Variation of C antigen Table III shows some of the Blood Group Unit’s results of testing samples with rare Rh phenotype against polyclonal anti-C. ComC represents commercial anti-C reagents, all others are single donor antibodies. The first three reagents do not contain any anti-D, the next three contain incomplete anti-D so are not suitable for tests with enzyme treated cells. The different patterns of reaction would make one suspect that these cells carried different variants of C; most variants are also distinguished by their reactions with antibodies to low incidence Rh antigens (Table III). Low incidence antigen JAL (RH48) JAL+ cells have a very weak C antigen, it is most easily detected with commercial reagents (Table III). The antibody in Mrs S Allen’s serum was studied for many years in several laboratories interested in low incidence antigens. There were some hints that it might be an Rh antigen, although Mrs Allen’s husband had been an unremarkable cDe. Eventually several samples expressing the JAL antigen were identified. However, family studies had not proved that JAL was an Rh antigen, although 3 of the propositi had a depressed c antigen and 4 had a depressed C antigen, 2 of whom also had a depressed e antigen [35]. A second immune example of anti-JAL, which caused haemolytic disease of Mrs Pas’ third". In Transfusion Immunology and Medicine, 193. CRC Press, 1995. http://dx.doi.org/10.1201/9781482273441-12.

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Atti di convegni sul tema "U.S. vs. Germany"

Iris, Radermacher, Beckedahl Jutta, Scholz Ute, Pezeshkpoor Behnaz, Preisler Barbara, Oldenburg Johannes e Pavlova Anna. "Diagnostic of Large Genetic Defects in Blood Coagulation Genes: NGS vs. MLPA". In Hamburger Hämophilie Symposion Hamburg, Germany. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1721612.

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Fleischer, T., C. Ulke, S. Speerforck, T. Gfesser, H. Mühlan, H. Glaesmer, JM Fegert et al. "East vs. West: Differences in the prevalence of child maltreatment in Germany before the reunification". In Das Soziale in Medizin und Gesellschaft – Aktuelle Megatrends fordern uns heraus 56. Jahrestagung der Deutschen Gesellschaft für Sozialmedizin und Prävention (DGSMP). Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1732105.

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Cortelazzo, S., D. Castagna, M. Galli, T. Barbui e G. de Gaetano. "INCREASED RESPONSE TO ARACHIDONIC ACID AND U-46619 AND RESISTANCE TO INHIBITORY PR0STAGLANDING IN PATIENTS WITH CHRONIC MYELOPROLIFE RATIVE DISORDERS". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643381.

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The potency of prostaglandins (PGs) D2, I2 and as inhibitors of platelet aggregation induced by threshold aggregating concentration (TAC) of arachidonic acid (AA) and U-46619 was determined in platelet rich plasma from 20 normal subjects and 20 patients with thrombocytosis (≥500×l09 platelets/L) secondary to myeloproliferative disorders. Patients had a significantly increased response to both AA and U-46619 (p< 0.02) than the control group (i.e. TAC for AA, mean+SD, was 0.41±0.10 mM vs 0.48±0.12 mM ; TAC for U-46619 was 220±155 nM vs 375±102 nM). In contrast, platelet sensitivity to all three inhibitoty PGs was significantly lower in patients than in normal subjects. Indeed the threshold inhibiting concentrations (nM) of PGs against AA were the following: PGD2 20.33±4.16 vs 7.00±2.62 (p< 0.001), PGI2 0.76±0.46 vs 0.34±0.22 (p< 0.01) and PGE1 11.83±3.97 vs 6.50±2.22 (p<0.001). The corresponding inhibitory concentrations (nM) against U-46619 were the following: PGD2 4.67±4.24 vs 0.76±0.30 (p< 0.02), PGI2 1.15±0.96 vs 0.03±0.01 (p< 0.0001) and PGE1 21.12±15.27 vs 0.68± 0.30 (p< 0.0001). Selective pharmacologic inhibition of TxA2 sinthase by 40 μM dazoxiben resulted in 6 out of 11 “responders” in patients and 7 out of 10 in normal subjects, a difference not statistically significant. Serum TxB2 was slightly, but not significantly lower in patients than in controls (360±143 ng vs 390±155 ng/3×109 platelets/mL). It is suggested that in patients with myeloproliferative disorders platelet arachidonate metabolism is normal, but the functional response to aggregating and antiag-gregating prostanoids is altered towards a potential hyperaggrega bility. The relevanbe of this “in vitro” finding to thrombotic or haemorragic complications in these patients remains to be establi shed.

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Green, D., T. Cohn, P. Filbrandt, V. Ito, M. Y. Lee, J. Press e W. C. Vandenberg. "THROMBOEMBOLISM PROPHYLAXIS IN SPINAL CORD INJURY: FIXED VS ADJUSTED DOSE HEPARIN". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643596.

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We had previously estimated the incidence of deep vein thrombosis (DVT) in untreated spinal cord injury patients with complete motor paralysis to be 78% (Paraplegia 20:227, 1982). Therefore, we have begun to randomize patients to receive prophylaxis with either fixed dose heparin (5,000 u every 12 h subcutaneously) or adjusted dose heparin (mean dose, 13,890 u every 12 h). Treatment is started within 72 hrs of injury, and continued for 12 weeks. Nineteen subjects have received the fixed dose for 155 weeks, and 21 the adjusted dose for 153 weeks (p = N.S.). Patients have had daily clinical examinations for thromboembolism/bleeding, and weekly doppler flow and impedance plethysmography studies. All suspected DVTs have been confirmed by venography. The activated partial thromboplastin time (aPTT) with the fixed dose has average 26 ± 1.5s (S.D.) and with the adjusted dose, 39.6 ± 7.6s (p < 0.001). There have been 2 episodes of pulmonary embolism and 2 DVTs in the fixed dose group and 1 DVT in an adjusted dose patient whose aPTT never rose above 26s. The thromboses were noted after 2, 3, 3, 4, and 6 weeks of prophylaxis. Bleeding occurred in 2 patients on the adjusted dose regimen and required withdrawal of the heparin; no subject on the fixed dose bled. Our preliminary conclusion is that heparin prophylaxis significantly reduced the frequency of thromboembolism in spinal cord injury patients. While fewer and less severe thrombotic events have occurred in those receiving adjusted doses, the decrease has not yet reached statistical significance (x2 = 1.16). Furthermore, there appears to be a small, but definite risk of bleeding on this regimen. Thus, additional patients are being studied to determine the optimum use of heparin in this population.

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Bagge, L., E. Holmer, S. O. Nystroöm, H. Tydeén e T. Wahlberg. "FRAGMIN VS HEPARIN AT RECYCLING OE HUMAN BLOOD IN HEART-LUNG MACHINE (HLM)". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643042.

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During cardio-pulmonary bypass (CPB), Heparin inhibits EXa (EXal), thrombin and platelet activity and is also reported to induce fibrinolysis. Eragmin (Erag) has 25% thrombin inhibition capacity as related to that of Heparin (Hep). An in_vitro study was performed to compare Frag with Hep by circulating blood in a pure artificial system. In 20 experiments, 400 ml of freshly collected blood with Frag or Hep were recycled for 2 h. HLM was primed with 400 ml of Ringeracetate. Blood sampling: donor, blood pack and every 20 min from the oxygenator. V_a£i£ble£/jassay/:ACT/Hemochron/5 APTT , TT and NT/Nyegaard/;FXaI, FVIII and ATIiT t"ATA)/amydolytic/; AT 111 (ATAg) and vWF/IEP/;Plasminogen (Pig) and albumine/immuno-diffusion/;FDP/Wellcome/;Platelet function/Adeplat S/;Fibrinogen (Fbg)/clottable/;Hemolysis (HL)/photometric/; (β -Thromboglobulin ((βTG)/RTA/;EVF, Hb, platelet count (PC) and Leucocyte count (LC)/ conventional). Corrections for hemo-/plasma dilutions were calculated. Dosages (n): Frag: 750 (1), 1500 (3), 2100 (4), 2500 (4) FXal-U (U); Hep: 1000 (3), 1500 (6) IU clinical level. Clotting only occurred at Frag 750 (1) and 1500 (2) U, when ACT, APTT, FVIII, Fbg and ATA were significantly lowered. Generally, PC fell 75% during the recycling, while PF was constant'∼20% and (βTG increased. Neither presence of FDP nor Pig consumption were detected. FXal, ACT, APTT, TT and NT were dose dependent for both drugs. ATA was directly dose-related to Frag but inversely to Hep. LC decreased with the Frag-dose but inversely to that of Hep. HL increased generally. Several proteins increased (clotting excl): Fbg 30%, ATAg 25%, ATA 45?o and vWF 60%. Conclusions. Prevention of clotting required about the double dosage of Frag. Shortened ACT and APTT predicted clotting while the levels of FXal, TT and NT did not. Thus, an effective thrombin inhibition is needed under this conditions. Consumptions of FVIII, Fbg and ATA but no further drop in PC at clotting, indicate weak platelet aggregation involvement. Absence of fibrinolytic signs supports that the fibrinolysis seen at CPB, is not a genuine effect of Hep (or Frag). Increases in some proteins may be caused by cytolysis. The rise in vWF is probably due to release from platelet surfaces.

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Gerhart, T., H. Yett, A. Donovan, M. A. Lee, M. Smith e E. W. Salzman. "ORGANON 10172 VS. WARFARINTO PREVENT VENOUS THROMBOSIS AFTER HIP FRACTURE". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643686.

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Deep venous thrombosis (DVT) remains a serious and frequent complication after fracture of the hip, and even the mostefficacious prophylactic agents, e.g., warfarin, may fail to prevent DVT in up to 2056 of cases. There is evidence that low molecular weight heparin or heparin-like agents may have advantages in antithrombotic prophylaxis with reduced hemorrhagic sideeffects in patients at risk of DVT. We are engaged in a randomized prospective trial comparing the antithrombotic effect ofwarfarin (PT 1.5x control)with that of Organon 10172, a mixture ofsulfated low molecular weight glycosamioglycans (750 anti-Xa u b.i.d. sc., begunpreop and continued 9 days, followe by warfarin). Diagnosis is by 125-1 fibrinogen scan and impedence plethysmography with confirmatory phlebography. At present71 patients have been admitted, and patient groups are comparable in age, sex, type of fracture, and all other significant respects. DVT has been diagnosed in 7of 36 patients given warfarin an in 1 of35 patients who received Organon10172. Pulmonary embolism has not beenencountered. GI bleeding has occurred twice on warfarin and once on Organon 10172 There has been no difference in estimated operative blood loss, transfusion requirements, or other major bleeding complications.One patient on warfarin died ofmyocardial infarction and pneumonia. There were no other adverse reactions.The study is still in progress. The present trend in the results suggests that the heparinoid Organon 10172 may be a promising new agent to prevent DVT in high risk patients, such as those with fractures of the hip.

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Nakstad, Britt, e Torstein Lyberg. "LOCAL ACTIVATION OF COAGULATION AND FIBRINOLYSIS IN LUNG DISEASE IS REFLECTED IN BR0NCH0ALVE0LAR LAVAGE FLUID". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643054.

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Fibrin deposition in the alveolar space and the lung interstitium is a prominent feature of many types of pulmonary inflammatory diseases.Ce11s of the monocyte/ macrophage lineage have a dualistic role in the balance between coagulation and fibrinolysis having the ability to synthesize both procoagulant factors and plasminogen activators. In the present studies bronchoa1veo1 ar lavage were performed on 128 patients with various lung diseases and 29 healthy controls.Both lung alveolar macrophages (LAM) and the supernatant bronchoalveolar lavage fluid (BALF) expressed two types of procoagulant activities a)thromboplastin and b) a direct factor X activator.The procoagulant in BALF was associated with membrane vesicles which sedimented at 100000g,lh.By electron microscopy the BALF ultrasediment was seen to consist for a large part of membrane material and this was confirmed by monitoring the content of different marker enzymes for specific subcellular structures. LAM from patients had significantly higher specific thromboplastin activity than LAM from controls (4,36 -0.98(SEM)vs.0.81± 0.14 U/mg cell protein).BALF collected from patients had significantly higher levels than BALF from controls of a ) thrombop1 astin(0.66-0.18vs.0.07 ±0.01 U/ml) b ) factor VII activity(1.33±0.31vs.0.48±0.06 U/ml) c)fibrin degradation products(presentin 28,7vs.0% of the cases) and d) fibronectin(491±103 vs.35±5 ng/ml ) In addition,the level of plasminogen activator was higher in controls than in patients(294±68 vs.!02±14 m U/m1).These studies show that activation products of the coagulation and fibrinolytic systems can be detected in BALF and that lung disease often is associated with abberations in the balance between these systems.Fibrin serves as a substrate for fibronectin and the increases in lavage fibronectin may reflect the development of lung fibrosis.

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Nilsson, T., O. Johnson e F. Lithner. "MOLECULAR MARKERS OF ENDOTHELIAL CELL DYSFUNCTION: OBSERVATIONS ON EXTRINSIC FIBRINOLYSIS IN SURVIVORS OF MYOCARDIAL INFARCTION AND IN TYPE-1 DIABETES MELLITUS". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643102.

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We have studied the extrinsic fibrinolytic system in survivors, below 70 years, from myocardial infarction (AMI) treated in Umeci during 1983; in 43 type-1 diabetics; and in controls. Elderly controls underwent chest x-ray, ECG, EEG, brain CT scan to verify their health. Tissue plasminogen activator (tPA) activity was measured with a fibrin-stimulated rate assay, before and after a 10 min venous occlusion test (VO), tPA antigen (Ag) with an ELISA, and plasminogen activator inhibitor (PAI) by incubating samples with purified tPA and measuring remaining tPA with a polylysine-stimulated rate assay.In the diabetics, PAI and tPA:Ag were similar to the controls. tPA:Ag correlated with age (r=0.6). Diabetics had much higher specific activity of tPA (61,300 vs 21,900), and had also much higher tPA activity after VO (2.2 vs 1.2 U/ml). The tPA activities after VO correlated well with HbA1c (r=0.39). A significant effect of smoking was disclosed. Smoking diabetics had higher PAI and tPA antigen but also lower specific activity of tPA (60,600 vs 115,700 U/mg). Ex-smokers were very similar to smokers, not to the non-smokers. Retinopathy, nephropathy, or hypertension didn’t appear to affect fibrinolysis independently.In the AMI survivors (sampled 3 months after discharge from hospital), PAI was 6-fold higher than in elderly controls (p less than 0.0001). tPA activity after VO was much higher (3.2 vs 1.2 U/ml), as was tPA:Ag. tPA specific activity was lower. Among AMI patients with PAI over 10 U/ml, PAI correlated with triglycerides (r=0.4) and negatively with age (r=™0.4): these relations were not seen in the patients with PAI less than 10. The effects of smoking seen in diabetics were not observed among the AMI patients, von Willebrand factor was not increased among AMI nor diabetic patients, except for those with retinopathy.The results suggest that the tPA/PAI system is a more sensitive indicator than vWF of endothelial cell dysfunction. It relates to effects of age, atherosclerotic vascular disease, and among diabetics also to degree of metabolic control and to tobacco smoking habits.

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KG, Simon, Y. Serfert, P. Buggisch, S. Mauss, Böker KH, H. Klinker, T. Müller et al. "Evolution of hepatitis C virus genotype 1a vs. 1b distribution reflects profound changes of HCV epidemiology in Germany between 2004 and 2018 - Analysis of 17,093 patients from five consecutive registries including the German Hepatitis C-Registry (DHC-R)". In DGVS Digital: BEST OF DGVS. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1716166.

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Stuart, M. J., P. D. Sadowitz e B. N. Y. Setty. "PLATELET 12-HYDROXY-5,8,10-HEPTADECATRIENOIC ACID (HHT) STIMULATES PROSTACYCLIN PRODUCTION BY ENDOTHELIAL CELLS". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642836.

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Abstract (sommario):

Although HHT accounts for approximately one third of the ara-chidonic acid (AA) metabolites produced by stimulated platelets, no well defined function has been attributed to this platelet product. We report that HHT stimulates prostacyclin production by endothelial cells, and have identified the mechanism for this effect. In human umbilical venous endothelial cells HHT (0.5 and 1pM) stimulated prostacyclin (RIA for 6KPGF1α) by 32±10% (1 SE) and 42±13% (P<0.05 and (0.01). Similar changes were observed when the effect of HHT on exogenous [1 -14C] AA metabolism in fetal bovine aortic endothelial cells (FBAECs) was studied. 6KPGF1α was stimulated by 25±9% and 30±6% at HHT cones, of 0.5 and 1μM (P<0.05) . While prelabelling experiments with [1-14c] AA revealed that HHT (1μM) did not affect the ionophore stimulated release of AA from FBAEC membrane lipids (29521±11837 cpm/well control vs 32458+8811 in HHT treated cells, mean ±1SD) kinetic analyses revealed that HHT affected vascular cyclooxygenase. HHT (1μM) increased Vmax in test microsomes (706±21 pmol/mg/min) when compared to controls (529±20; P<0.02). No effect on Km was observed (6.2±0.3μM control vs. 7.2±0.4 in HHT treated microsomes). The effect of HHT on platelet AA metabolism was next studied. Preincubation of washed platelets with HHT (1μM) did not enhance thrombin (0.2 U/ml) induced pit. TXB2 (2.27±1.34 pmol/106 platelets control vs 2.28±1.62 in HHT treated platelets). In platelets prelabelled with [ 1-14c] AA, HHT (1μM) also had no effect on AA release post thrombin stimulation (5794_423 cpm per 108 platelets control vs. 6135±612 for paired HHT treated cells). Conversion to cyclooxygenase metabolites was also not enhanced (2605±265 vs 2806±332 for test platelets). HHT thus stimulates vascular prostacyclin without a concomitant effect on platelet AA metabolism. Our findings may explain the discrepancies relative to prostacyclin production in atherosclerosis and diabetes. In these disorders while ex vivo production of prostacyclin by vascular tissue is decreased, in vivo production is elevated. HHT may also be an important local modulator of platelet plug formation and could play a protective antithrombotic role by its hitherto unrecognized effect on vascular prostacyclin.

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