Tesi sul tema "Tumeurs du cerveau – secondaire"
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Imbs, Sylvain. "Les nitrosourees de deuxieme generation : apports therapeutiques dans le traitement des tumeurs cerebrales primitives et secondaires : exemple de la fotemustine (muphoran)". Université Louis Pasteur (Strasbourg) (1971-2008), 1991. http://www.theses.fr/1991STR1M050.
Ogunleke, Abiodun. "Imagerie chimique 3D de tumeurs du cerveau". Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0040/document.
Three-dimensional (3D) histology is a new advanced tool for cancerology. The whole chemical profile and physiological characteristics of a tissue is essential to understand the rationale of pathology development. However, there is no analytical technique, in vivo or histological, that is able to discover such abnormal features and provide a 3D distribution at microscopic resolution.Here, we introduce a unique high- throughput infrared (IR) microscopy method that combines automated image correction and subsequent spectral data analysis for 3D-IR image reconstruction. I performed spectral analysis of a complete organ for a small animal model, a mouse brain with animplanted glioma tumor. The 3D-IR image is reconstructed from 370 consecutive tissue sectionsand corrected using the X-ray tomogram of the organ for an accurate quantitative analysis of thechemical content. A 3D matrix of 89 x 106 IR spectra is generated, allowing us to separate the tumor mass from healthy brain tissues based on various anatomical, chemical, and metabolic parameters. I demonstrate for the first time that quantitative metabolic parameters (glucose, glycogen and lactate) can be extracted and reconstructed in 3D from the IR spectra for the characterization of the brain vs. tumor metabolism (assessing the Warburg effect in tumors). Our method can be further exploited by searching for the whole spectral profile, discriminating different anatomical landmarks in the brain. I demonstrate this by the reconstruction of the corpus callosum and basal ganglia region of the brain
DEBAVELAERE, VINCENT. "Polyamines erythrocytaires et tumeurs cerebrales". Lille 2, 1991. http://www.theses.fr/1991LIL2M048.
Cicero, Julien. "TrkA dans les métastases cérébrales des cancers du sein triple négatifs". Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS031.
Nearly 90% of deaths in breast cancer patients are due to metastasis. Triple-negative(TN) breast cancer is characterized by its aggressive nature and high propensity to metastasize. Among the various sites of metastasis, the development of brain metastasis is associated with the worst prognosis, with a greater impact on patients'quality of life. The mechanisms underlying the progression of brain metastases in triplenegativebreast cancer are incompletely understood. To address this gap, we have used several experimental models to study the behavior of breast cancer cells during the process of dissemination to the brain. These models include an in vitro human blood-brain barrier (BBB) model, in vitro 3D organotypic extracellular matrix, ex vivo co-cultures of mouse brain slices, and in vivo xenograft experiments. By recapitulating the final key steps of brain metastasis in these models, we sought to better understand the underlying molecular mechanisms. In this work, we demonstrate the involvement of TrkA and its co-receptors (e.g. EphA2) in the development of brain metastases. First, we identified the TrkA/EphA2 receptor complex as a mediator of proNGF-induced BBB transmigration. Furthermore, our results showed that combined inhibition of TrkA and EphA2 significantly reduced brain metastasis in a preclinical breast cancer model. These results challenge the current understanding of the mechanisms of brain metastasis and highlight the role of proNGF as a key factor in the brain tropism of metastatic TN breast cancer
DESENCLOS, CHRISTINE. "Les tumeurs du troisieme ventricule : 24 observations". Lille 2, 1993. http://www.theses.fr/1993LIL2M237.
LARRIEU, ELISABETH. "Tumeurs cerebrales primaires multiples d'histologie differente : a propos d'une observation (considerations etiologiques)". Bordeaux 2, 1988. http://www.theses.fr/1988BOR25048.
Bonnenfant, Mézeray Valérie. "Les tumeurs cerebrales a revelation antenatale : experience nanceienne et revue de la litterature". Nancy 1, 1993. http://www.theses.fr/1993NAN11199.
DIAZ, JUAN. "Tumeurs cerebrales a expression psychiatrique : a propos d'un cas de meningiome temporal". Université Louis Pasteur (Strasbourg) (1971-2008), 1993. http://www.theses.fr/1993STR1M042.
Khotanlou, Hassan. "Segmentation 3D de tumeurs et de structures internes du cerveau en IRM". Phd thesis, Télécom ParisTech, 2008. http://pastel.archives-ouvertes.fr/pastel-00003662.
CHEVALIER, GAULTIER NATHALIE. "Evolution du traitement des tumeurs germinales malignes cerebrales : a propos de 12 observations". Lille 2, 1988. http://www.theses.fr/1988LIL2M120.
DAVROUX, CHRISTINE, e OLIVIER GUINARD. "Les tumeurs germinales cerebrales malignes secretant de l'alpha foetoproteine : approche diagnostique et therapeutique actuelle". Lille 2, 1993. http://www.theses.fr/1993LIL2M022.
GERVESY, GILLES. "Ponction percutanee des tumeurs cerebrales sous guidage scanner : a propos de 86 observations". Lyon 1, 1991. http://www.theses.fr/1991LYO1M360.
Jost, Jean-Brice. "Tumeurs cérébrales non rehaussées en TDM et IRM : aspects diagnostiques et évolutifs". Université Louis Pasteur (Strasbourg) (1971-2008), 1991. http://www.theses.fr/1991STR1M176.
DE, SURVILLE BRESSAC SANDRINE. "Tumeurs cerebrales chez des enfants irradies pour l. A. L". Nantes, 1993. http://www.theses.fr/1993NANT256M.
Mallol, Nathalie Clavel Jacqueline. "Caractéristiques périnatales et risques de tumeur maligne du système nerveux central de l'enfant". [S.l.] : [s.n.], 2006. http://www.scd.uhp-nancy.fr/docnum/SCDMED_T_2006_MALLOL_NATHALIE.pdf.
SUC, ETIENNE. "Tumeurs cerebrales chez les enfants de moins de trois ans : etude retrospective de 98 cas traites a l'institut gustave roussy". Toulouse 3, 1990. http://www.theses.fr/1990TOU31082.
Lefevre, Philippe. "Tumeurs cérébrales primitives de l'enfant : expérience du service de cancérologie de Bordeaux". Bordeaux 2, 1994. http://www.theses.fr/1994BOR23088.
CANNONI, ZATTARA HELENE. "Apport de la cytogenetique et de l'hybridation in situ (fish) au pronostic des tumeurs cerebrales". Aix-Marseille 2, 1993. http://www.theses.fr/1993AIX20907.
ZAHAF, NAOUFEL. "Place de la radiotherapie dans le traitement des tumeurs cerebrales : a propos de 32 cas traites dans le centre hospitalier de rodez". Toulouse 3, 1988. http://www.theses.fr/1988TOU31192.
Tanter, Mickael. "Application du retournement temporel à l'hyperthermie ultrasonore du cerveau". Paris 7, 1999. https://pastel.archives-ouvertes.fr/pastel-00650031.
PECHALAT, PHILIPPE. "Le risque de neoplasme transmis a partir d'organes transplantes : aspect particulier des tumeurs cerebrales : a propos de quatre dossiers cliniques". Lyon 1, 1988. http://www.theses.fr/1988LYO1M365.
Piel, Clément. "Tumeurs du système nerveux central et expositions agricoles aux pesticides". Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0466/document.
In the international literature, agricultural exposures to pesticides have been put forward as a key hypothesis to explain the excess of brain tumours observed in farmers. The aim of this thesis, based on data from the Agrican cohort, was to investigate the role of agricultural exposures to pesticides in the incidence of the main histological types of central nervous system tumours. With more than 180,000 participants followed since 2005, the Agrican cohort is one of the largest studies on health in agriculture. Internal comparisons adjusted for the main important confounders showed increases in risk among farmers, more pronounced risk among pesticide users, and with strong variations according to the types of crop and livestock farming. Following these initial analyses, work identified carbamate pesticides as a priority to study in relation to brain tumours. Next, further development of the Pestimat served to reconstitute the history of carbamate uses since 1950 in the main French agricultural contexts. After these intermediate steps, survival analyses conducted among Agrican participants showed increased risks of glioma and meningioma in farmers exposed to (dithio/thio)-carbamates, particularly with those recommended for use on vineyards, fruits, potatoes and beets. These findings reinforce the evidence of carcinogenicity among pesticides already suspected for other cancers, and draw attention to other active ingredients, less documented in the literature but relatively homogeneous in terms of chemical structures. Therefore, on the basis of these conclusions and with a public health objective in mind, it seems essential to pursue efforts to reduce farmers' exposure to pesticides
Levrier, Olivier. "Aspects en imagerie par resonance magnetique des tumeurs supratentorielles de la ligne mediane chez l'adulte". Aix-Marseille 2, 1990. http://www.theses.fr/1990AIX20834.
Alric, Matthieu. "Conception et modélisation modulaire d'un robot bio-inspiré extensible pour l'accès aux tumeurs dans le cerveau". Phd thesis, Université Blaise Pascal - Clermont-Ferrand II, 2009. http://tel.archives-ouvertes.fr/tel-00724718.
Kucharczak, Jérôme. "Neuropeptides et migration cellulaire : une étude du transcriptome dans les cellules tumorales de côlon et de cerveau". Montpellier 1, 2001. http://www.theses.fr/2001MON13504.
Monteil, Pascal. "Modifications de la semeiologie clinique des tumeurs cérébrales sus-tentorielles depuis l'introduction de la tomodensitométrie". Bordeaux 2, 1990. http://www.theses.fr/1990BOR23035.
Plas, Martine. "A propos d'un cas de corticosurrénalome malin découvert à partir d'une hypersomnie : observation-revue de la littérature-discussion". Montpellier 1, 1991. http://www.theses.fr/1991MON11140.
Bonzom, Sébastien. "Développement et caractérisation d'une sonde radiosensible dédiée à l'assistance au traitement chirurgical des tumeurs cérébrales". Paris 7, 2006. http://www.theses.fr/2006PA077076.
Chirurgical excision is still the more efficient treatment for high grade brain tumors. Pre-operative imaging techniques (scanner, RMI) give informations to neurosurgeon like the localization or the size of the tumor. However, these locales are lost during the surgery because of the brain shift of tissues due to the intracranium pressure. Intra-operative imaging techniques give access to real time informations on the tumor during the operation. The radiosensitive beta probe TRIOP which is the subject of this document is an intra-operative detecter dedicated to brain tumor surgery coupled to the excision tool (an ultrasound aspirator). The surgeon will be able to control an area of thé brain and to excise it without moving his aspirator. This scanning procédure allows to minimize the correlation mistakes between the image given by the détecter and the real position of the tumor into the operative wound. TRIOP is built around plastic scintillating fibers and its optimum geometry was defined by Monte Carlo simulations using the MCNP code. A first prototype built on thé spécifications give by the simulations had been evaluated on radioactive phantoms representing the clinical context. TRIOP was able to detect small areas c tumor (up to 5 mm of diameter) when using radiopharmaceuticals currently available. Following these promising results, an evaluation on some patients will be realized in the next months
Même, Sandra. "Caracterisation tissulaire en irm par l'analyse de texture : etude du tissu musculaire et de tumeurs intracraniennes". Rennes 1, 1999. http://www.theses.fr/1999REN1B039.
Maffeo, Véronique. "Statut et rôle des images médicales du cerveau humain dans l'enseignement secondaire français : approches didactique, épistémologique et socio-historique". Lyon 1, 1999. http://www.theses.fr/1999LYO10321.
Delisle, Marie-Bernadette. "Les gliomatoses cérébro-méningées : discussion de leur place dans l'histoire des gliomes". Aix-Marseille 2, 1987. http://www.theses.fr/1987AIX21913.
ESTABLET, HELENE. "La gh favorise-t-elle la recidive des tumeurs cerebrales chez l'enfant ? revue de la litterature ; experience du service de pediatrie du chu de nice". Nice, 1993. http://www.theses.fr/1993NICE6568.
Campagne, Gérard. "Le syndrome de turcot : polypose recto-colique familiale et tumeurs malignes du systeme nerveux central : a propos d'une observation : revue de la litterature". Bordeaux 2, 1987. http://www.theses.fr/1987BOR25117.
Taillandier, Luc. "Etude des facteurs pronostiques cliniques, radiologiques, anatomopathologiques et lies a la cinetique cellulaire des tumeurs astrocytaires sus-tentorielles, primitives de l'adulte : a propos de 119 observations". Nancy 1, 1993. http://www.theses.fr/1993NAN11164.
Minéo, Jean-François. "Evaluation de l'immunothérapie locale par anticorps monoclonal anti-CD20 pour le traitement du lymphome primitif cérébral et intraoculaire dans un modèle murin immunocompétent". Lille 2, 2009. http://www.theses.fr/2009LIL2S012.
Marchal, Frédéric. "Approche expérimentale du traitement local des métastases hépatiques : hyperfréquence, thérapie photodynamique, modèles animaux". Nancy 1, 2005. http://docnum.univ-lorraine.fr/public/SCD_T_2005_0224_MARCHAL.pdf.
Padovani, Laëtitia. "Caractérisation moléculaire des tumeurs cérébrales circonscrites de l'enfant". Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM5018.
The OMS classification for pediatric brain tumors includes glial tumors and mixed glial and glioneuronal tumors, diffuse and no diffuse glioma. All strategic decision making are based on this current classification but it drives to some limits of diagnosis reproductibility.The goal of our study was to define molecular profils for low grade no diffuse pediatric brain tumors including pilocytic astrocytoma (PA), dysembryoplasic neuroepithelial tumor (DNT), pleiomorphic xanthoastrocytoma (PXA) and benign gangliogliome (GG), to improve the quality of diagnosis, define different subgroups with different prognosis and then to improve treatment strategy decision making.No molecular difference was found between cortical grade II glioma (GC) and DNT regarding IDH1 and 2 TP53 alterations and 1p19q deletion. Similarly 50 % of no specific form of DNT share the same molecular profil with GC with CD34 expression and V600E mutation of BRAF. PXA demonstrated BRAFV600E mutation in 60 % of cases. PXA could then be very close glioneuronal tumors. Finally in PA we confirmed the negative impact of hypothalochiasmatic location, pilomyxoid diagnosis and age lower than 36 months and partial resection. We could work on the elaboration of a new classification and define the group named “Histone dependant” for tumors with histone aberrations and the group named “MAPKinases dependant” for tumors with either KIAA 1543-BRAF fusion or V600E BRAF mutation.In conclusion, this work has led to improve the molecular profil characteristics of glioneuronal tumors of childhood with different easy diagnostic markers that can be used in routine practice, and could potentially replace DNA sequencing
Venteo, Lydie. "Etude des proteines du cycle cellulaire, de la résistance aux inhibiteurs des topoisomérases et des virus polyoma dans 84 tumeurs cérébrales humaines astrocytaires et oligogliales : immunohistochimie, hybridation in situ et biologie moléculaire". Reims, 2007. http://www.theses.fr/2007REIMP214.
Fellah, Slim. "Exploration par IRM multimodale des tumeurs cérébrales de l'enfant et de l'adulte. : Lésions épileptogènes, tumeurs oligodendrogliales et glioblastome". Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5035.
Conventional MRI is considered as the gold standard method for the non-invasive diagnosis, pretherapeutic assessment and follow-up of brain tumors in adults and in children. However, due to its lack of specificity for both differential diagnosis and evaluation of the response to treatment, several MR modalities are now added to the conventional exam in order to refine the exploration of these tumors. The use of a single modality is however not yet sufficient to establish an accurate diagnosis or prognosis for brain tumors. For this reason, we were interested in the combination of data from different MR modalities in order to obtain a better characterization of these neoplasms. In this context, we used multimodal MRI to investigate 1) pediatric epileptogenic tumors, for which it is crucial to establish a preoperative diagnosis in order to make appropriate surgical and therapeutic decisions; 2) oligodendroglial tumors in adults, hardly distinguishable and which therapeutic decisions are mainly based on the determination of the tumoral grade and molecular profile; and 3) the response of glioblastoma to anti-angiogenic treatments. Through this work, we have shown that the association of different imaging modalities provides a significant contribution to the differential pre-therapeutic diagnosis of epileptogenic brain lesions in children and also of oligodendroglial tumors in adults as well as a support for the early assessment of tumoral response to anti-angiogenic therapies
Vertongen, Pascale. "Contribution à l'étude du rôle du PACAP et du VIP dans le cerveau ainsi que dans des tumeurs d'origine neuroectodermique et hypophysaire". Doctoral thesis, Universite Libre de Bruxelles, 1997. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212224.
Le, Joncour Vadim. "Étude du remodelage tumoral associé aux effets du peptide vasoactif urotensine II sur la néoangiogenèse et la croissance des glioblastomes". Rouen, 2015. http://www.theses.fr/2015ROUENR01.
Chapus, Jean-Jacques. "Sclérose tubéreuse de Bourneville et insulinome : association fortuite ? : à propos d'un cas, revue de la littérature". Bordeaux 2, 1994. http://www.theses.fr/1994BOR2M143.
Parisot, Sarah. "Compréhension, modélisation et détection de tumeurs cérébrales : modèles graphiques et méthodes de recalage/segmentation simultanés". Phd thesis, Ecole Centrale Paris, 2013. http://tel.archives-ouvertes.fr/tel-00944541.
Vasiljevic, Alexandre. "Caractérisation des fonctions neuroprotectives des interfaces sang-cerveau au cours du développement normal, dans les tumeurs périventriculaires et dans un modèle d’excitotoxicité périnatale". Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1328/document.
Blood-brain interfaces including blood-brain barrier (BBB), choroid plexuses (CP) or circumventricular organs (CVO) are physiological barriers required for brain homeostasis. These barriers are “physical”, with tight junctions, and “enzymatic”. Though long considered immature in fetuses, these barriers are present from an early stage of development. Their characteristics and their properties are largely unknown in humans. Our work demonstrates that CP express tight junction-associated proteins claudins (CLDN) 1, 2, and 3 at early stages of development in rat and human. This expression is dynamic during development as shown by the progressive increase of CLDN2 immunopositivity that may follow increase in cerebrospinal fluid secretion. CLDN 1 and 3 are identified in human fetal subcommissural organ (SCO), one of the CVO. CLDN5 is early expressed in rat and human BBB and its expression is disrupted by excitotoxic injury. Our work also shows that CLDN immunohistochemical profile is useful in tumoral pathology, notably to better understand and diagnose tumors arising from CP or the SCO. Finally, various antioxidant and detoxifying enzymes such as the microsomal epoxide hydrolase are expressed at 22 weeks of gestation in the human fetus, mainly in CP. These results suggest a high detoxifying capacity for the CP during development in humans
Charrier, Colette. "Polyglobulie secondaire à un fibrome utérin : à propos d'un cas , mise en évidence d'une activité érythropoi͏̈etique dans le sang, les urines et la tumeur : revue de la littérature". Bordeaux 2, 1989. http://www.theses.fr/1989BOR25324.
Hemm, Simone. "Mise en concordance d'images sous cadre stéréotaxique : applications neurochirurgicales". Montpellier 1, 2005. http://www.theses.fr/2005MON1T010.
Simon, Thomas. "Traitement anti-angiogénique par le bevacizumab des tumeurs gliales malignes : étude in vitro dans une matrice tridimensionnelle". Rouen, 2014. http://www.theses.fr/2014ROUES032.
Glioblastomas (grade IV gliomas) are one of the most invasive and aggressive solid tumors. Bevacizumab, a humanized monoclonal antibody directed against the pro-angiogenic factor Vascular and Endothelial Growth Factor-A (VEGF-A), is used in the treatment of glioblastomas. Although most patients respond initially to this treatment, studies have shown that glioblastomas eventually recur. Several non-mutually exclusive theories based on the anti-angiogenic effect of bevacizumab have been proposed to explain these mechanisms of resistance. In this report, we studied whether bevacizumab can act directly on malignant glioblastoma cells. We observe changes in the expression profiles of components of the VEGF/VEGF-R pathway and in the response to a VEGF-A stimulus following bevacizumab treatment. In addition, we show that bevacizumab itself acts on glioblastoma cells by activating intracellular survival signaling pathways. Bevacizumab also enhances proliferation and invasiveness of glioblastoma cells in Hyaluronic Acid (HA) hydrogel. We propose that the paradoxical effect of bevacizumab on glioblastoma cells could be due to changes in the VEGF-A-dependent autocrine loop as well as in the intracellular survival pathways, leading to the enhancement of tumor aggressiveness. Identification of mediators involved in the direct effect of bevacizumab on glioblastoma cells and the resulting downstream signaling pathways will help to develop multi-targeted therapies useful in the treatment of glioblastomas
Tayrac, Marie de. "Analyse génomique et transcriptomique des glioblastomes multiformes". Rennes 1, 2009. http://www.theses.fr/2009REN1B126.
Glioblastomas are among the most devastating of human nervous system tumors. Advances in Functional Genomic and particularly in the development of high-throughput technologies - such as microarrays -, allow the analysis of both DNA alterations and gene expression changes on a genome-wide scale. They make possible the identification of molecules involved in tumor initiations, development and progression as well as the discovery of useful biomarkers to improve patient care. The present research takes place in such a context. Our initial objective was to provide genomic and transcriptomic characterization of glioblastomas. We had specificially to identify the DNA alterations that directly drives the disease process - i. E. Alterations that may exert their tumor-promoting effect by modifying the expression or function of distinct genes, so as to deregulate growth factor signaling and survivor pathways. Completion of this project has firstly required a methodological development to allow the simultaneous analysis of large scale data sets coming from different "-omic" areas. Glioblastoma genome and transcriptome profiling were obtained and combined to provide a robust molecular signature characterizing these tumors. We have also expanded our work to search for biomarkers for diagnosis and prognosis of patient with malignant gliomas. This thesis has been driven by a multidisciplinary approach - such an approach being necessary to the analysis of high throughput studies. We therefore wished to provide a substantial introduction, which would help everyone - clinicians, biologists, and statisticians - to get the fundamentals required to understand our work
Dou, Weibei. "Segmentation d'images multispectrales basée surla fusion d'informations : application aux images IRM". Phd thesis, Université de Caen, 2006. http://tel.archives-ouvertes.fr/tel-00111904.
fusion d'informations basée sur la théorie floue pour la segmentation
d'une cible à partir de plusieurs sources d'images. Notre application
principale porte sur la segmentation des images IRM multispectrales. Nous proposons une approche de segmentation automatique basée sur la fusion des caractéristiques extraites de chaque source d'image. Ces caractéristiques sont modélisées par des fonctions d'appartenance, obtenues à partir de fonctions analytiques, qui prennent en compte des connaissances a priori sur la possibilité d'appartenance à une cible (tumeur ou tissus cérébraux) donnée par l'expert, et aussi la gradation d'intensité du signal de la cible.
La segmentation d'une cible consiste finalement à fusionner les
différents degrés d'appartenance de la cible. Une étape supplémentaire basée sur une croissance 3D des régions floues est proposée pour améliorer le résultat de la fusion. Pour évaluer les résultats de segmentation représentés par un ensemble flou, une extension du coefficient Kappa de Cohen, nommée " Kappa flou " est proposée, qui est une méthode d'évaluation globale sur la proportion d'agrément d'un classement flou.
Cette architecture développée est mise en œuvre pour la segmentation des tumeurs cérébrales à partir des images IRM qui comprennent pour l'instant les séquences de routine : T1, T2 et densité de protons. Les résultats sur sept patients atteints de tumeur montrent l'efficacité de notre système.
Li, Xiaobing. "Automatic image segmentation based on level set approach: application to brain tumor segmentation in MR images". Reims, 2009. http://theses.univ-reims.fr/exl-doc/GED00001120.pdf.
The aim of this dissertation is to develop an automatic segmentation of brain tumors from MRI volume based on the technique of "level sets". The term "automatic" uses the fact that the normal brain is symmetrical and the localization of asymmetrical regions permits to estimate the initial contour of the tumor. The first step is preprocessing, which is to correct the intensity inhomogeneity of volume MRI and spatially realign the MRI volumes of the same patient at different moments. The plan hemispherical brain is then calculated by maximizing the degree of similarity between the half of the volume and his reflexion. The initial contour of the tumor can be extracted from the asymmetry between the two hemispheres. This initial contour is evolved and refined by the technique "level set" in order to find the real contour of the tumor. The criteria for stopping the evolution have been proposed and based on the properties of the tumor. Finally, the contour of the tumor is projected onto the adjacent images to form the new initial contours. This process is iterated on all slices to obtain the segmentation of the tumor in 3D. The proposed system is used to follow up patients throughout the medical treatment period, with examinations every four months, allowing the physician to monitor the state of development of the tumor and evaluate the effectiveness of the therapy. The method was quantitatively evaluated by comparison with manual tracings experts. Good results are obtained on real MRI images