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Tesi sul tema "Transferases"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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1

Corrigall, Anne Vint. "Human glutathione S-transferases : characterization, tissue distribution and kinetic studies." Doctoral thesis, University of Cape Town, 1988. http://hdl.handle.net/11427/27205.

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In this study the purification of human basic and near-neutral liver, and human basic and acidic lung glutathione S-transferases (GSH S-T) was undertaken. Purification of the basic and near-neutral GSH S-T was achieved using a combination of affinity chromatography, chromatofocusing and immunoaffinity chromatography. Affinity and ion exchange chromatography were employed in the purification of the basic and acidic lung forms. The purified proteins had similar physicochemical characteristics to the GSH S-T purified by others. The binding of 1-chloro-2,4-dinitrobenzene (CDNB) to the 3 classes of

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2

Goold, Richard David. "The glutathione S-transferases : kinetics, binding and inhibition." Doctoral thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/27175.

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The glutathione S-transferases are a group of enzymes which catalyse the conjugation of reduced glutathione with a variety of electrophilic molecules, and they are therefore thought to play a major role in drug biotransformation and the detoxification of xenobiotics. The cytosolic GSH S-transferase isoenzymes of rat, man and mouse have been assigned to three groups, Alpha, Mu and Pi, based on N-terrninal amino acid sequences, substrate specificities, immunological cross-reactivity and sensitivities to inhibitors. The kinetic mechanism of the GSH S-transferases is controversial, due to the obse

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3

Mosi, Renée M. "Mechanistic studies on Ã-glycosyl transferases." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ34594.pdf.

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4

Dixon, David Peter. "Glutathione transferases in maize (Zea mays)." Thesis, Durham University, 1998. http://etheses.dur.ac.uk/4788/.

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The glutathione transferases (GSTs) of maize have been the most studied GSTs in plants, however much is still not known about these enzymes. In the course of the current study six GST subunits (Zm GSTs I, II and III, which have been reported previously, and Zm GSTs V, VI and VII, which have not been previously reported) have been identified in the dimers Zm GST I-I, I-II, I-III, V-V, V-VI and V-VII. Maize GSTs are known to be important in herbicide detoxification and the purified maize enzymes were each found to have differing activities toward a number of herbicides, and also a range of other

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5

Barrozo, Alexandre. "Promiscuity and Selectivity in Phosphoryl Transferases." Doctoral thesis, Uppsala universitet, Struktur- och molekylärbiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-279693.

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Phosphoryl transfers are essential chemical reactions in key life processes, including energy production, signal transduction and protein synthesis. They are known for having extremely low reaction rates in aqueous solution, reaching the scale of millions of years. In order to make life possible, enzymes that catalyse phosphoryl transfer, phosphoryl transferases, have evolved to be tremendously proficient catalysts, increasing reaction rates to the millisecond timescale. Due to the nature of the electronic structure of phosphorus atoms, understanding how hydrolysis of phosphate esters occurs i

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6

Hayes, Peter C. "Glutathione S-transferases in the pancreas." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/19832.

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Glutathione S-transferase (GST) is an important xenobiotic metabolising enzyme which has been extensively studied in the liver. In the first part of this study immunohistochemistry was used to identify the presence and histological localisation of different GST isoenzymes in various gastrointestinal tract tissues in the human in health and disease. GSTP was found throughout the gastrointestinal and biliary tract whilst the position and quantity of other isoenzymes varied locally. Increased expression of GSTP was observed in cholangiocarcinoma and colonic adenocarcinoma, but not hepatocellular

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7

DAWOOD, KUTAYBA F. "New physiological roles of glautathione transferases." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/923.

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Glutathione transferases (GSTs) are enzymes able to conjugate GSH to a lot of toxic compounds thereby favoring their excretion. Recently, other protective roles of these enzymes have been discovered. In particular, it has been observed that a peculiar and strong interaction exists between some mammalian GSTs and an endogenous carrier of nitric oxide, the dinitrosyl-diglutathionyl iron complex (DNDGIC). This iron complex is a paramagnetic molecule with a characteristic EPR spectrum centered at g = 2.03, that is spontaneously formed when NO enters the cell. This complex is a strong irreversible

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8

Dolan, Catherine. "Regulation of mouse hepatic glutathione S-transferases." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/23855.

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The glutathione S-transferases (GST) are a multi-gene family of dimeric proteins which catalyse the conjugation of glutathione to a wide range of electrophilic compounds. Three classes of mouse cytosolic GST have been isolated, alpha, mu and pi, comprising Ya-, Yb- and Yf-type subunits respectively. A marked sexual dimorphism in mouse hepatic GST has been observed. The YfYf GST is the most abundant form in the male, constituting approximately 70% of total hepatic GST content. By contrast, the Yf subunit represents only a minor form in the livers of female mice. The hormonal controls which regu

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9

Meikle, Ian. "Glutathione S-transferases in the adrenal cortex." Thesis, University of Edinburgh, 1992. http://hdl.handle.net/1842/19139.

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Data available prior to this thesis had shown that, of all bovine organs examined, the adrenal cortex exhibited the second highest level of glutathione S-transferase (GST) expression behind the liver. This finding, along with increasing evidence implicating the importance of GST in endogenous detoxification processes, formed the basis for a further extensive investigation of the GST isoenzymes expressed by the adrenal cortex. Investigation of the GST isoenzymes expressed by a number of different bovine organs using affinity chromatography on S-hexylglutathione-Sepharose 6B (S-hexG-Ag) revealed

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10

Hill, Alison Elspeth. "Regulation of glutathione S-transferases during stress." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/19846.

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Elevation of glutathione S-transferases (GST) in tumour cells can be responsible for resistance to a variety of chemotherapeutic agents. It has been hypothesised that GSTs may be induced as part of a stress response, similar to that of the prokaryotic adaptive response. To further this investigation I studied the induction of GSTs in a variety of permanent and transient stress models. A chlorambucil resistant CHO cell line which was known to express increased levels of Alpha-class GST was studied to determine the nature of the increase in protein. Northern and Southern blot analysis revealed a

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11

Entova, Sonya. "Structure-function relationships in monotopic phosphoglycosyl transferases." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122206.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2019<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Complex glycans play essential roles in prokaryotic and eukaryotic biology. While this ubiquitous post-translational modification takes a diversity of forms, many glycoconjugate biosynthesis pathway across domains of life follows a common logic. Glycan assembly is initiated by a phosphoglycosyl transferase (PGT) that transfers a phosphosugar from a nucleotide donor to a polyprenol phosphate (PrenP) chain embedded in the membrane.

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12

Thumser, Alfred Ernst Adolf. "The glutathione S-transferases : inhibition, activation, binding and kinetics." Thesis, University of Cape Town, 1990. http://hdl.handle.net/11427/28958.

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13

Eklund, Birgitta I. "Role of Multiple Glutathione Transferases in Bioactivation of Thiopurine Prodrugs : Studies of Human Soluble Glutathione Transferases from Alpha, Kappa, Mu, Omega, Pi, Theta, and Zeta Classes." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7102.

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14

Smith, Lisa Stievater. "Factors influencing glutathione S-transferases in (Daphnia magna)." College Park, Md. : University of Maryland, 2006. http://hdl.handle.net/1903/3801.

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Thesis (M.S.) -- University of Maryland, College Park, 2006.<br>Thesis research directed by: Marine, Estuarine, Environmental Sciences Graduate Program. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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15

Howie, Alexander Forbes. "Measurement of human glutathione S-transferases by radioimmunoassay." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/24005.

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A purification scheme was devised for human glutathione S-transferase (GST) pi that resulted in a high yield of homogeneous protein from human placenta, lung and erythrocytes. Polyclonal antisera against GST pi from lift lung and placenta was raised in eight rabbits. The GST pi proteins purified from placenta, lung and erythrocytes were found to have identical isoelec-tric points (pl= 4.8), subunit molecular weights (Mr= 24 800) and were found to be immunologically identical. The antibody demonstrating the best specificity and sensitivity was employed to develop a radioimmunoas-say (RIA) for t

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16

Matas, Nada. "Molecular genetics of human arylamine N-acetyl transferases." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338241.

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17

Thom, Russell. "Structural studies of glutathione S-transferases from plants." Thesis, University of Glasgow, 2000. http://theses.gla.ac.uk/6648/.

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The aim of this thesis was to structurally characterise a range of plant GSTs to increase the understanding as to which structural features determine substrate specificity. During the course of this work, a total of ten plant GSTs from species including Maize, Wheat, Carnation, Petunia and Arabidopsis thaliana were overexpressed in E. coli. Nine of these overexpressed GSTs were purified the produce protein for crystallisation using a range of matrices such as Orange A agarose, S-hexyl glutathione and metal chelate followed by ion-exchange and/or gel filtration chromatography depending on the p

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18

Andrews, Christopher John. "Glutathione transferases in soybean Glycine max (L.) Merr." Thesis, Durham University, 1999. http://etheses.dur.ac.uk/4857/.

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Abstract (sommario):

Glutathione transferases, also known as Glutathione S-transferases (GSTs), are a diverse group of enzymes that catalyse the conjugation of the tri-peptide glutathione to a wide range of electrophilic substrates. Their biological function in endogenous metabolism in plants is not well characterised, although their role in herbicide metabolism and herbicide selectivity is well documented. Many herbicides used in soybean. Glycine max (L.) Merr., are selective against weeds due to their rapid detoxification in the crop through conjugation with homoglutathione (γ-glu-cys-β-ala), the predominant fre

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19

Banger, Kulwinder Kaur. "Glutathione S-transferases of the rat nasal cavity." Thesis, Liverpool John Moores University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261475.

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20

Harris, Jonathan Malcolm. "The glutathione S-transferases of rat liver mitochondria." Thesis, University College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325084.

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21

Taylor, James Philip. "Synthesis of novel acceptor substrates for mannosyl transferases." Thesis, University of Exeter, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317390.

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22

Guelfi, Andréa. "Bioinformática estrutural aplicada à evolução das glutationas transferases." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-04052006-161903/.

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As glutationas transferases compõem uma superfamíla de proteínas que atuam na fase II do sistema de desintoxicação das células. Participam principalmente através do processo de conjugação da glutationa com moléculas hidrofóbicas e eletrofílicas, como por exemplo os herbicidas. No entanto, outras funções foram descritas como a tolerância ao estresse oxidativo, inseticidas, antibióticos microbianos, transporte de produtos secundários tóxicos, sinalização da célula durante as respostas ao estresse e fenômenos de resistência envolvendo agentes de quimioterapia contra o câncer. Nesta tese procurou

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23

Stockman, Paul Kennedy. "The glutathione S-transferases in human liver cytosol." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/26977.

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A purification scheme is described for the basic and neutral glutathione S-transferases which occur in human liver. Three forms with basic isoelectric points, B-|Bi (pl'8.9), B-|B2 (pi 8.75) and B2B2 (pi 8.4) and two forms with neutral isoelectric points, N-j (pi 6.1) and N2 (pi 4.6), were obtained. Not every liver examined expressed transferase N-] or transferase N2^ An acidic enzyme from human lung, GST \ (pi 4.8), was included in the study for the purpose of comparison. Sodium dodecylsulphate/polyacrylamide-gel electro? phoresis demonstrated that each enzyme comprises two subunits of identi

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24

Copp, Janine Naomi Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Catalysed activation of cyanobacterial biosynthetic pathways by phosphopantetheinyl transferases." Awarded by:University of New South Wales. School of Biotechnology and Biomolecular Sciences, 2005. http://handle.unsw.edu.au/1959.4/33254.

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Cyanobacteria produce a diverse array of natural products with significant potential in many biotechnological, clinical and commercial applications. These include pharmaceuticals, such as antitumour products, antibiotics, immunosuppressants, anticholesterolemics and anti-parasitic agents, as well as veterinary therapies and agrochemicals. These compounds are synthesised by complex secondary metabolism pathways involving polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS), both of which require an essential phosphopantetheinyl transferase (PPT) for their activity. PPTs activ

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25

Ati, Jihen. "Leishmanian Galactofuranosyltransferases as promising versatile tools for therapeutic and chemoenzymatic approaches." Thesis, Orléans, 2018. http://www.theses.fr/2018ORLE2043.

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Les cellules exposent à leurs surface glycoconjugués qui jouent important dans des événements biologiques importants tels que la communication entre cellules, la croissance de cellules saines ou cancéreuses et les processus d'infection d'agents pathogènes. Certaines structures polysaccharidiques qui contiennent le résidu Galf ont attiré beaucoup d’intérêt au cours des dernières décennies. En effet, le galactofuranose peut être exprimé chez de nombreuses espèces pathogènes, telles que Mycobacterium tuberculosis, Aspergillus et Leishmania, mais il est absent chez les mammifères. Par conséquent,

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26

Molin, Eva U. "In vitro characterization of glutathione transferases from Sarcoptes scabiei /." Uppsala : Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, 2009. http://epsilon.slu.se/200980.pdf.

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27

Fedulova, Natalia. "Alpha-class Glutathione Transferases from Pig: a Comparative Study." Doctoral thesis, Uppsala universitet, Institutionen för biokemi och organisk kemi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-144119.

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Abstract (sommario):

Glutathione transferases (GSTs, EC 2.5.1.18) possess multiple functions and have potential applications in biotechnology. This thesis contributes to knowledge about glutathione transferases from Sus scrofa (pig). The study is needed for better understanding of biochemical processes in this species and is desirable for drug development, for food industry research and in medicine. A primary role of GSTs is detoxication of electrophilic compounds. Our study presents porcine GST A1-1 as a detoxication enzyme expressed in many tissues, in particular adipose tissue, liver and pituitary gland. Based

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28

Hatton, Pamela J. "Role of glutathione transferases in herbicide detoxification in weeds." Thesis, Durham University, 1996. http://etheses.dur.ac.uk/5443/.

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Glutathione transferases (GSTs) catalyse the conjugation of the electrophilic herbicides atrazine, metolachlor, alachlor and fluorodifen with the tripeptide glutathione (GSH). Maize (Zea mays L), contains multiple GSTs with differing substrate specificities which confer tolerance to a variety of herbicides. In contrast far less is known regarding the GSTs in competing weed species. In vivo metabolism studies using seedlings of maize and the weeds Panicum miliaceum. Digitaria sanguinalis, Sorghum bicolor. Setaria faberi. Abutilon theophrasti and Echinochloa crus-galli demonstrated that all spec

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29

Flaherty, Christopher. "Glycosyl derivatives as acceptors and inhibitors of mycobacterial transferases." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341460.

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30

Todorova, Tatina. "Glutathione S-transferases and oxidative stress in Saccharomyces cerevisiae." Université Louis Pasteur (Strasbourg) (1971-2008), 2007. https://publication-theses.unistra.fr/public/theses_doctorat/2007/TODOROVA_Tatina_2007.pdf.

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Les glutathion S-transférases répresentent une famille d'enzymes impliquée dans la détoxification de composés d’origine éxogène et endogène. Les GSTs peuvent avoir des activités péroxidase ou isomérase et également d’exprimer fonctions non-catalytiques, comme l’interaction avec differents ligands ou la modulation de la signalisation cellulaire. Un éventail des mutants de S. Cerevisiae a été choisi pour étudier le rôle des GSTs dans la réponse au peroxide et à l’arsenic. Notre criblage a montré l’existance de deux GSTs, qui peuvent avoir un rôle dans la détoxification de ces composés. Tef4p est

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31

Todorova, Tatina Vuilleumier Stéphane Kujumdzieva Anna. "Glutathione S-transferases and oxidative stress in Saccharomyces cerevisiae." Strasbourg : Université Louis Pasteur, 2007. http://eprints-scd-ulp.u-strasbg.fr:8080/814/01/Todorova_Tatina_2007.pdf.

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Thèse de doctorat : Aspects moléculaires et cellulaires de la biologie : Strasbourg 1 : 2007. Thèse de doctorat : Aspects moléculaires et cellulaires de la biologie : Sofia - Bulgarie : 2007.<br>Thèse soutenue en co-tutelle. Titre provenant de l'écran-titre. Bibliogr. f. 143-155.

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32

Lyon, Robert Patrick. "Enzymology at the dimer interface of cytosolic glutathione S-transferases /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/8165.

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Bamber, Dianne Elizabeth. "Polymorphism in loci encoding detoxyfying enzymes : its role in cancer susceptibility and outcome." Thesis, Keele University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246867.

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34

Scott, Trevor Robert. "The identification, purification and characterization of the fetal rat liver glutathione S-transferase isoenzyme YcYfetus." Doctoral thesis, University of Cape Town, 1988. http://hdl.handle.net/11427/27171.

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This study has examined the expression of the glutathione S-transferases (GSH S-T) in fetal rat livers in order to provide more information about the role played by this important group of enzymes in the fetus. The study commenced with an examination of the subunit composition of adult and fetal rat liver GSH S-T using affinity chromatography followed by polyacrylamide gel electrophoresis in sodium dodecyl sulphate. Adult livers contained four major GSH S-T subunits. An additional and previously unidentified subunit was detected in fetal livers. This subunit, which differed from that found in

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35

Mutanda, Taurai. "Purification, characterisation and application of inulinase and transferase enzymes in the production of fructose and oligosaccharides." Thesis, Rhodes University, 2008. http://hdl.handle.net/10962/d1007734.

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Inulin hydrolysis can occur as a result of the action of exoinulinases and endoinulinases acting alone or synergistically. Exoinulinases cleave the non-reducing β-(2, I) end of inulin releasing fructose while endoinulinases act on the internal linkages randomly to release inulotrioses (F₃), inulotetraoses (F₄) and inulopentaoses (F₅) as major products. Fructosyltransferases act by cleaving a sucrose molecule and then transferring the liberated fructose molecule to an acceptor molecule such as sucrose or another oligosaccharide to elongate the short chain fructooligosaccharide. The production o

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36

Bastos, Frederico Freire. "Melatonina, isoenzimas de glutationa S-transferases e estresse oxidante em pacu Piaractus mesopotamicus (Holmberg, 1887)." Universidade do Estado do Rio de Janeiro, 2010. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2991.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>O oxigênio é fundamental para os vertebrados. No entanto, variações dos níveis de oxigênio na água podem provocar estresse oxidante em peixes porque privação de oxigênio seguida de reoxigenação forma espécies reativas de oxigênio (ERO) em células. Níveis intracelulares de ERO aumentados favorecem que moléculas de proteínas, fosfolipídios e ácidos nucleicos sofram alterações, vindo a prejudicar muitas funções celulares. No Pantanal, habitat do pacu, o nível de oxigênio varia circadianamente na água das lagoas rasas que acabam isol

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Kurtovic, Sanela. "Directed Evolution of Glutathione Transferases Guided by Multivariate Data Analysis." Doctoral thesis, Uppsala University, Department of Biochemistry and Organic Chemistry, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8718.

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<p>Evolution of enzymes with novel functional properties has gained much attention in recent years. Naturally evolved enzymes are adapted to work in living cells under physiological conditions, circumstances that are not always available for industrial processes calling for novel and better catalysts. Furthermore, altering enzyme function also affords insight into how enzymes work and how natural evolution operates. </p><p>Previous investigations have explored catalytic properties in the directed evolution of mutant libraries with high sequence variation. Before this study was initiated, funct

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38

Caniard, Anne M. "Glutathione transferases : probing for isoform specificity using dynamic combinatorial chemistry." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/4731.

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Cytosolic glutathione transferases (GSTs) are a large family of enzymes that play an important role in detoxification of xenobiotics. They catalyse the conjugation of the glutathione tripeptide (GSH) to a wide range of toxic electrophilic acceptors. The overall 3D folds and architectures of the catalytic sites of many GSTs are conserved. They are composed of a well conserved glutathione binding site (G-site) and a promiscuous hydrophobic binding site (H-site). The 3D structure and ligand specificity has allowed the sub-classification of the multiple isoforms within the soluble GST superfamily.

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Li, Yaxiao. "Diverse roles of protein S-acyl transferases in Arabidopsis thaliana." Thesis, University of Bath, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.715280.

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S-acylation, commonly known as S-palmitoylation, is a reversible posttranslational lipid modification in which fatty acid, usually palmitic acid, covalently attaches to specific cysteine residues of proteins via thioester bonds. Palmitoylation enhances the hydrophobicity of proteins and contributes to their membrane association. It plays roles in protein trafficking, signalling, protein-protein interaction, protein stability and other important cellular functions. A family of Protein S-acyl Transferases (PATs) is responsible for this reaction. PATs are multi-pass transmembrane proteins that po

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Schmidt, Marie-Joëlle. "Characterisation of cytoplasmic uridyl transferases in yeast and human cells." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:e3831ff6-2b5f-4456-a91c-4ac0cca52594.

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Regulation of gene expression by terminal addition of uridyl residues to RNA substrates has recently emerged as a widespread phenomenon in eukaryotes. Studies in organisms ranging from fission yeast to human cells have shown that uridylation of RNA 3' ends stimulates rapid RNA degradation. However, many questions regarding the specificity of the uridyl transferases, the broad range of their substrates and the consequences of their loss are still unanswered. In light of this, the uridyl transferases Cid1 in Schizosaccharomyces pombe and ZCCHC11 in human cells and their roles in the regulation o

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Favrot, Lorenza. "Structure and Enzymatic Characterization of Mycobacterium tuberculosis Transferases." University of Toledo / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1404588587.

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Sparrow, Helen. "The role of glutathione transferases in the detoxification of TNT." Thesis, University of York, 2010. http://etheses.whiterose.ac.uk/1470/.

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Manufacture, use, storage and improper disposal of the explosive 2,4,6-trinitrotoluene (TNT) have led to widespread, global contamination of soil and groundwater. TNT is highly toxic and recalcitrant to degradation resulting in environmental build-up with far reaching ecological and health implications. It is therefore a priority to remove contaminating TNT from the environment. Phytoremediation is a promising solution; suitable plants possess some natural ability to transform TNT, high biomass, deep root systems, requirement for minimal nutrient input and ability to reduce contamination sprea

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43

Sharath, B. "Structure and kinetics of gamma glutamyl transferases from bacillus species." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2008. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2665.

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44

Jonsson, Stefan. "The mechanism of Formyl-Coenzyme A transferase, a Family III CoA transferase, from Oxalobacter formigenes." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0007068.

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45

Ricagno, Stefano. "Formyl-coenzyme A transferase, structure and enzymatic mechanism /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-028-1/.

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46

Hilton, John Frederick. "The molecular basis of glutamate formiminotransferase deficiency /." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33776.

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Abstract (sommario):

Glutamate formiminotransferase deficiency (OMIM 229100) is an autosomal recessive disorder marked by clinical heterogeneity. The severe phenotype, first identified in patients of Japanese descent, includes high levels of formiminoglutamate (FIGLU) in the urine in response to histidine loading, megaloblastic anemia, and mental retardation. The mild phenotype is marked by high levels of FIGLU in the urine in the absence of histidine loading, mild developmental delay and no hematological abnormalities. The gene for human glutamate formiminotransferase-cyclodeaminase consists of 15 exons and is lo

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47

Jiang, Hong, and 姜紅. "Effects of estrogen on human catechol-O-methyl transferase." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31241864.

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48

Jiang, Hong. "Effects of estrogen on human catechol-O-methyl transferase." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23273744.

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49

Lu, Weiya Douglas. "Photophysical consequences from interactions of glutathione S-transferases with the photodynamic sensitizer hypericin /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/8638.

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50

Street, Ian Philip. "Fluorinated carbohydrates as probes of mechanism and specificity in glycosyl transferases." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/29434.

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Abstract (sommario):

The Compounds 2-deoxy-2-fluoro-β-D-glucosyl fluoride (1), 2,4-dinitrophenyl 2-deoxy-2-fluoro-β-D-glucoside (2), 2-deoxy-2-fluoro-β-D-galactosyl fluoride (3) and 2-deoxy-2-fluoro-β-D-mannosyl fluoride (4) were all found to be potent covalent inhibitors of β-glucosidase from Alcaligenes faecalis (pABG5 β-glucosidase), which function through the accumulation of a stable glycosyl-enzyme intermediate. The mechanism of action for these inhibitors was investigated and found to be both specific and active site directed, involving a 1:1 stoichiometric formation of an enzyme inhibitor complex. Investig

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