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1
Schneider, Florian, Stefan Schlatt, Nina Neuhaus e Sabine Kliesch. "Fertilätsprotektion bei Mann-zu-Frau trans Personen: Früh an fertilätsprotektive Maßnahmen denken". Zeitschrift für Sexualforschung 33, n. 03 (settembre 2020): 169–71. http://dx.doi.org/10.1055/a-1216-7015.
Testo completoAbstract (sommario):
ZusammenfassungWir stimmen dem in der Leitlinie genannten starken Konsens für Maßnahmen der Reproduktionsmedizin als wichtige Option zur Erfüllung des Kinderwunsches bei trans Personen uneingeschränkt zu. Informationen über diese Maßnahmen müssen Bestandteil von Behandlungen von trans Personen sein. Die geschlechtsangleichende Hormontherapie bei Mann-zu-Frau trans Personen hat jedoch einen negativen Einfluß auf die Spermatogenese. Der Erfolg der Fertiltätsprotektion bei Mann-zu-Frau trans Personen hängt stark von Qualität und Quantität der Spermien bzw. der spermatogonialen Stammzellen ab. Daher sollte die Beratung vor der geschlechtsangleichenden Hormontherapie stattfinden. Zu Beginn sollten eine ausführliche Anamnese, eine körperliche Untersuchung, eine Untersuchung von Serumhormonen (LH, FSH, Testosteron, Östradiol, AMH, Inhibin B) und ggf. eine Untersuchung des Ejakulats erfolgen. Zu den etablierten Methoden der Fertilitätsprotektion zählen Kryokonservierung von Spermien nach Ejakulation, Kryokonservierung von Spermien nach mikrochirurgischer testikulärer Spermienextraktion (mTESE) oder Spermienaspiration aus dem Nebenhoden (MESA) oder Kryokonservierung von spermatogonialen Stammzellen. Letztere sind auch möglich, wenn die geschlechtsangleichende Hormontherapie vor Beginn der Pubertät begonnen wird. Dies ist derzeit noch experimentell. Kryokonservierte Spermien können dazu verwendet werden, im Rahmen einer In-vitro-Fertilisation (IVF) und intrazytoplasmatischen Spermieninjektion (ICSI) mit Frauen eigene Kinder zu zeugen. Leihmutterschaft oder Eizellenspende ist in Deutschland derzeit nicht möglich.Wir wollen betonen, dass das Gespräch über fertilitätsprotektive Maßnahmen so früh wie möglich stattfinden muss, um den Erfolg zu garantieren und Absprachen zwischen den medizinischen Diszplinen zu ermöglichen. Das Ziel sind individuelle Lösungen, die für trans Personen finanzierbar, gangbar und operativ mit einfachen Mitteln zu erreichen sind.
2
Rabouille, C., N. Hui, F. Hunte, R. Kieckbusch, E. G. Berger, G. Warren e T. Nilsson. "Mapping the distribution of Golgi enzymes involved in the construction of complex oligosaccharides". Journal of Cell Science 108, n. 4 (1 aprile 1995): 1617–27. http://dx.doi.org/10.1242/jcs.108.4.1617.
Testo completoAbstract (sommario):
The distribution of beta 1,2 N-acetylglucosaminyltransferase I (NAGT I), alpha 1,3-1,6 mannosidase II (Mann II), beta 1,4 galactosyltransferase (GalT), alpha 2,6 sialyltransferase (SialylT) was determined by immuno-labelling of cryo-sections from HeLa cell lines. Antibody labelling in the HeLa cell line was made possible by stable expression of epitope-tagged forms of these proteins or forms from species to which specific antibodies were available. NAGT I and Mann II had the same distribution occupying the medial and trans cisternae of the stack. GalT and SialylT also had the same distribution but they occupied the trans cisterna and the trans-Golgi network (TGN). These results generalise our earlier observations on the overlapping distribution of Golgi enzymes and show that each of the trans compartments of the Golgi apparatus in HeLa cells contains unique mixtures of those Golgi enzymes involved in the construction of complex, N-linked oligosaccharides.
3
Paula, Flávia Cristina S. de, Josiane Nicácio Silveira, Roberto Gonçalves Junqueira e Edna Maria Alvarez Leite. "Avaliação do ácido trans, trans-mucônico urinário como biomarcador de exposição ao benzeno". Revista de Saúde Pública 37, n. 6 (dicembre 2003): 780–85. http://dx.doi.org/10.1590/s0034-89102003000600014.
Testo completoAbstract (sommario):
OBJETIVO: Avaliar o uso do ácido trans, trans-mucônico urinário como biomarcador na monitorização da exposição ocupacional ao benzeno. MÉTODOS: Foi estudado o comportamento do ácido trans, trans-mucônico em amostras de urina de indivíduos expostos (N=36) e não expostos (N=116) ocupacionalmente ao solvente. A concentração urinária do ácido foi determinada por Cromatografia Líquida de Alta Eficiência. A amostra foi constituída de indivíduos expostos ao benzeno em uma refinaria de petróleo localizada em Belo Horizonte, MG. Foram empregados os testes estatísticos não-paramétricos de Kruskall-Wallis, Mann Witney e de correlação de Spearman, ao nível de significância de 0,05%. RESULTADOS: A exposição média ao benzeno dos trabalhadores selecionados foi de 0,15±0,05 mg/m³ (0,05 ppm) o que resultou em um valor médio do metabólito urinário de 0,19±0,04 mg/g de creatinina. A faixa de referência do ácido trans, trans-mucônico no grupo não exposto variou de 0,03 a 0,26 mg/g de creatinina (média de 0,10±0,08 mg/g de creatinina). Foi encontrada uma diferença significativa entre os níveis de ácido trans, trans-mucônico do grupo exposto e não exposto. Entretanto, não houve correlação entre os níveis do metabólito urinário e do benzeno no ar. Foi observada a correlação entre ácido trans, trans-mucônico e hábito de fumar no grupo de indivíduos expostos. A ingestão de álcool num período de até 48 horas antes da coleta das amostras não mostrou interferir nos níveis do metabólito nos dois grupos estudados. Foi observada a correlação entre ácido trans, trans-mucônico e idade (faixa etária de 18 a 25 anos) no grupo de não expostos. CONCLUSÕES: Os resultados obtidos evidenciaram a importância de ser mais bem avaliada a influência do hábito de fumar e da faixa etária do trabalhador nos níveis urinários do ácido trans, trans-mucônico.
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Hamm, Jonas A., e Timo O. Nieder. "Trans*-Sexualität neu denken: Eine partizipative Interviewstudie zu gelingender Sexualität ohne Genitalangleichung". Zeitschrift für Sexualforschung 34, n. 02 (giugno 2021): 69–78. http://dx.doi.org/10.1055/a-1477-0412.
Testo completoAbstract (sommario):
Zusammenfassung Einleitung Studien zur Sexualität von trans* Personen sind häufig durch das heteronormative Bias geprägt, alle trans* Personen würden eine Genitalangleichung anstreben, um penil-vaginalen penetrativen Geschlechtsverkehr ausüben zu können, als (trans*) Mann in der insertiven, als (trans*) Frau in der aufnehmenden Rolle. Diese Studie untersucht erstmals die Sexualität von trans* Personen, die keine Genitalangleichung anstreben und mit ihrer Sexualität zufrieden sind. Forschungsziele Ziel der Studie ist es, die individuelle Sexualität von Menschen dieser Personengruppe zu beleuchten und die intrapsychischen, interaktionellen und kollektiven Ressourcen zu analysieren, auf die sie dabei zurückgreifen. Darunter fallen auch Strategien, um den scheinbaren Widerspruch von Geschlechtsidentität und Körperlichkeit zu überbrücken. Methoden Es wurden sechs leitfadengestützte qualitative Interviews durchgeführt und mithilfe einer inhaltlich strukturierenden qualitativen Inhaltsanalyse ausgewertet. Die Studie beinhaltete verschiedene partizipative Elemente. So wurden die Ergebnisse im Rahmen einer partizipativen Feedbackschleife durch die Teilnehmenden kommunikativ validiert. Ergebnisse Die Teilnehmer_innen berichten von vielfältigen, genitalen wie non-genitalen sexuellen Praktiken, die unabhängig von den damit assoziierten Geschlechterrollen stattfinden. Dabei greifen sie auf verschiedene Ressourcen und Strategien zurück. Insbesondere wird die geschlechtsanzeigende Funktion von Genitalien auf drei Ebenen dekonstruiert: individuell durch die Teilnehmenden selbst, interaktionell über die Anerkennung ihrer Geschlechtsidentität durch sexuelle Partner_innen und kollektiv durch die Communitys, in denen sie sich bewegen. Schlussfolgerung Die Studie entkräftet die oft unhinterfragte Vorannahme, dass trans* Personen per se ihre Genitalien nur widerwillig oder unter Erfahrungen von körperlicher Dysphorie in der Sexualität einsetzen. Mit den richtigen Ressourcen müssen sexuelle Rolle, Genitalienstatus und Geschlechtsidentität nicht stereotyp zusammenfallen, um gelingende Sexualität zu praktizieren.
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Abreu, Ana Clara Oliveira, Cirley Novais Valente Junior e Adriane Mesquita De Medeiros. "Relationship between Smoking and Vocal Self-perception of Trans Women". Revista de Investigación e Innovación en Ciencias de la Salud 5, n. 2 (30 novembre 2023): 24–36. http://dx.doi.org/10.46634/riics.197.
Testo completoAbstract (sommario):
Objective. To verify the relationship between smoking, age, schooling, and the vocal self-perception of trans women. Methods. Cross-sectional observational quantitative study conducted with 24 trans women over 18 years old, living in their affirmed gender for a minimum of 6 months. Data collection involved selected questions from the translated and authorized Portuguese version of the Trans Woman Voice Questionnaire (TWVQ) and information regarding age, education, occupation, and smoking status. All variables were analyzed descriptively, and the association with smoking was assessed using Pearson's Chi-square, Fisher's Exact, Student's T, and Mann-Whitney tests, with a significance level of 5%. Results. The mean age of trans women was 28.2 +/- 6.5 years (range: 21 - 48). Most participants (41.6%) had completed their high school education and pursued diverse careers. Regarding smoking habits, 58.3% of women were either current smokers or had smoked at least 100 cigarettes in their lifetime. A statistically significant association was found between smoking and age (p = 0.001), with smokers having a lower average age (24.9 years) compared to nonsmokers (32.9 years). However, no statistical significance was observed between smoking, education, and self-perception of vocal femininity. Only 9 (37.5%) trans women perceived their voices as feminine, while 17 (70.7%) desired a more feminine-sounding voice. Limitation. The limited sample size in this study may have constrained the ability to detect significant differences between the analyzed groups using statistical tests. Conclusion. The smoking prevalence was notably high among younger trans women. However, there was no statistically significant difference in vocal self-perception between those who smoked and those who did not. The majority of trans women expressed a desire for their voices to sound more feminine, particularly among smokers.
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Morais, HBlynda. "“Pane no cistema”". Revista Periódicus 1, n. 20 (13 marzo 2024): 45–71. http://dx.doi.org/10.9771/peri.v1i20.54801.
Testo completoAbstract (sommario):
O presente artigo tem por objetivo analisar cinco perfis da rede social Instagram com produção de conteúdos acerca da comunidade não binária. Os perfis utilizados foram: Coletivo Trans Não-Binárie (@coletivotransnaobinarie), Rexistência Não-Binária (@rexistencianaobinaria), Ser Não-Binário (@sernaobinario), Nick Nagari (@nicknagari) e Mar Facciolla (@mardemar.nb); todos eles analisados entre 2021-2022. Essa investigação permite entender como a articulação deste movimento tem criado suas rotas de fuga, subvertendo as armadilhas do CIStema, com o qual rompem, colaborando com o protagonismo trans nas redes. Aqui, debato até que ponto conseguimos cruzar a História com a não binariedade, compreendendo as disputas que há nas narrativas e nos discursos para que construamos histórias não binárias ou uma História da não binariedade no Brasil. Utilizo como aporte teórico: Cristiane Dias (2018), Maria Lugones (2014), Guacira Lopes Louro (2004), Megg Rayara Gomes de Oliveira (2020), Jota Mombaça (2021), Letícia Nascimento (2021), Fernando Seffner (2021), atrelada à Autobixografia (Thallys Mann, 2020) como ferramenta metodológica e minha escrevivência enquanto pessoa não binária para construção das narrativas. Assim, pretendo contribuir ao campo historiográfico dos estudos trans no nosso país.
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Andrea, Zella, e Sri Handayani. "Comparaison De Compréhension Dans La Compétence Transculturelle Chez Les Étudiants Ayant Et N’ayant Pas Le Cours Sur L’interculturalité, À Travers La Bande Dessinée". Didacticofrancia Journal Didactique du FLE 12, n. 2 (1 aprile 2024): 171–83. http://dx.doi.org/10.15294/didacticofrancia.v12i2.67672.
Testo completoAbstract (sommario):
Le but de cette recherche est de comparer la compréhension sur la connaissance transculturelle dans l’activité de la littératie interculturelle à travers la bande dessinée numérique intitulée "Dari Semarang ke Prancis, Perjalanan Lintas Budaya Indonesia - Prancis" chez les étudiants ayant et n’ayant pas le cours sur l’interculturalité. L'échantillon était composé de 56 étudiants de 10 universités en Indonésie. Le type d'échantillon utilisé est l'échantillonnage en grappes. La collecte de données a été effectuée à l'aide d'un test de la compréhension transculturelle sur quatre épisodes avec 20 questions à choix multiples et vrai-faux chacun via Google Form. En testant les données à l'aide du test de Mann-Whitney qui montre la signature Asymp. Sig. (2-tailed) à signification de 95 % de 0,001. Ainsi, il existe une différence significative dans la compréhension dans la littératie transculturelle chez les étudiants ayant et n’ayant pas le cours interculturel. Et puis, la compréhension dans la littératie transculturelle chez des étudiants ayant le cours interculturel sont meilleure que ceux qui n’ayant pas.
The aim of this research is to compare the comprehension of trans-cultural literacy between students who get cross-cultural courses and those who don’t, through digital comic entitled "Dari Semarang ke Prancis, Perjalanan Lintas Budaya Indonesia – Prancis”. The sample consisted of 56 students from 10 universities in Indonesia. The type of sample used is cluster sampling. Data collection was carried out using a trans-cultural comprehension test on four episodes with 20 multiple choice and true-false qestions each via Google Form. Testing the data using the Mann-Whitney test which shows Asymp. Sig. (2-tailed) at a significance level of 95% of 0.001, so there is a significant difference in comprehension of trans-cultural literacy for students who get and don’t get cross-cultural courses.
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Shafiekhani, Soraya, Jung Ae Lee e Griffiths G. Atungulu. "Prediction of Rice Milling Yield and Quality Attributes during Storage Using Regression Analyses". Transactions of the ASABE 62, n. 5 (2019): 1259–68. http://dx.doi.org/10.13031/trans.13441.
Testo completoAbstract (sommario):
Abstract. Regression analyses were performed to determine the storage conditions that exhibited the best outcomes for long-grain, hybrid milled rice yield and quality. This study evaluated mold population on rough rice, milled rice discoloration, and head rice yield (HRY) after storage of rough rice in airtight conditions at moisture contents (MCs) of 12.5%, 16%, 19%, and 21% wet basis and temperatures of 10°C, 15°C, 20°C, 27°C, and 40°C at two-week intervals for 12 weeks. The experiment used a popular long-grain hybrid rice cultivar (XL745). Rice lots were procured from fields with and without conventional treatment of the field with fungicide for plant disease management. Field treatment and no field treatment were considered as a block, and a Mann-Whitney test was conducted to determine effect. The response surface method, an extension of second-order polynomial regression, was used to examine optimal treatment conditions. Mold population and milled rice discoloration from a combination of storage conditions were predicted using regression models. The first-order and second-order terms of temperature indicated a nonlinear relationship between temperature and ln(discoloration). The MC was positively associated with ln(discoloration), but the degree of impact may change with temperature because the interaction term was significant. From the model evaluation (R2 and lack-of-fit test), the discoloration level is expected to be 57% (49% to 66% confidence interval) under conditions of 20% MC, 40°C, and nine weeks of storage for samples procured from fungicide-treated rice fields. This discoloration change is substantial compared to the initial discoloration of 9%. At high temperature (40°C) and MC (21%), discoloration started immediately after two weeks of storage. Anaerobic storage conditions impeded mold growth, especially at high storage temperature (40°C). Low mold populations were observed in rice stored at low MC (16%). According to the regression model, the critical storage temperature that may lead to discoloration is between 27°C and 40°C. Pre-harvest fungicide treatment of rice in the field for disease control significantly improved the HRY but had no significant influence on mold population or discoloration. This study suggests a range of storage conditions to prevent losses in milling yield and quality of rice. In addition, the studied storage conditions mimicked the typical conditions for on-farm, in-bin drying and storage in the U.S. Mid-South, especially for the top layers of rice inside the bin, and therefore provide an important reference for growers and rice processors using in-bin structures to manage the quality of long-grain hybrid rice. Keywords: Discoloration, Head rice yield, Mold population, Regression analysis, Rice quality, Rice storage.
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Küllertz, Gerhard, Sabine Lüthe e Gunter Fischer. "Semiautomated microtiter plate assay for monitoring peptidylprolyl cis/trans isomerase activity in normal and pathological human sera". Clinical Chemistry 44, n. 3 (1 marzo 1998): 502–8. http://dx.doi.org/10.1093/clinchem/44.3.502.
Testo completoAbstract (sommario):
Abstract An UV/VIS spectrophotometric assay technique was developed that was able to routinely monitor peptidylprolyl cis/trans isomerase (PPIase) activity of biological fluids in 96-well microtiter plates. The assay, based on monitoring the cis-to-trans isomerization of succinyl-Phe-cisPro-Phe-4-nitroanilide as substrate in a chymotrypsin-coupled reaction, yields a throughput of 96 samples per 30 min. The assay’s capacity was exemplified by dealing with the PPIase activity in several normal and pathological human sera. Reference values of 151 healthy subjects (83 females, 69 males, 17 to 60 years old) were found to possess significant sex-specific differences. PPIase activity factor K of the sera was significantly greater in males (5th, 50th, 95th percentiles: 17, 36, 55 K) than females (14, 30, 48 K). PPIase activities of sera from healthy donors (n = 151) were significantly higher (Mann–Whitney rank-sum test P <0.0001) than those of patients (n = 47). PPIase activity in serum samples stored at 4 °C was stable for at least 20 h.
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LI, YUHANG, HIDEKAZU SUZUKI, TAMOTSU NAGUMO e JIRO TANAKA. "Auxosporulation, morphology of vegetative cells and perizonium of Fallacia tenera (Hust.) D.G. Mann (Bacillariophyceae)". Phytotaxa 164, n. 4 (11 aprile 2014): 239. http://dx.doi.org/10.11646/phytotaxa.164.4.3.
Testo completoAbstract (sommario):
Specimens of Fallacia tenera were collected from the surface sediment at in a river estuary in Japan. Auxosporulation occurred in a rough culture. Morphological structures of vegetative cells and auxospores were observed in detail. The vegetative cells have one H-shaped chloroplast. The striae were interrupted by two depressed lateral sterna internally and partly covered by a finely porous conopeum on the external surface. The lateral sterna and porous conopea formed two more or less curved longitudinal canals connecting with the exterior via opening pores on both sides of a terminal fissure. This combination of characteristics is unique to the genus Fallacia. The cingulum was composed of three bands, such as an open valvocupula and two comparatively thin pleurae. The two pleurae could be distinguished by the shape of their ligulae. The second band had a triangular ligula, whereas the ligula of the third band is arc-shaped. The auxosporulation was type IA1a in Geitler’s classification. Two paired gametangia formed two anisogametes in each of them. Two auxospores formed in the thecae of the gametangia after a trans physiological anisogamy. The perizonium of the auxospore consisted of a set of transverse bands and five longitudinal bands. The primary transverse band was about twice wider than the secondary ones. The circular incunabular scales were present on the two terminals of the auxospore and on the surface of the primary transverse band. The primary longitudinal band had an acute terminal and was flanked by secondary longitudinal bands. Each side had two secondary longitudinal bands. All longitudinal bands were immediately beneath the transverse bands. Morphological comparison between Fallacia and Pseudofallaica, and the taxonomic position of F. tenera is also discussed.
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Xian, Junfang, Huarui Du, Xinyan Wang, Fei Yan, Zhengyu Zhang, Hui Hao, Bo Zhao, Yajian Tong, Jue Zhang e Demin Han. "Feasibility and value of quantitative dynamic contrast enhancement MR imaging in the evaluation of sinonasal tumors". Chinese Medical Journal 127, n. 12 (20 giugno 2014): 2259–64. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20140712.
Testo completoAbstract (sommario):
Background Quantitative dynamic contrast enhancement MR imaging (DCE-MRI), used to measure properties of tissue microvasculature and tumor angiogenesis, is a promising method for distinguishing benign and malignant tumors and characterizing tumor response to antiangiogenic treatment. The aim of this study was to assess the feasibility of quantitative parameters derived from clinically used DCE-MRI for distinguishing benign from malignant tumors in the sinonasal area, which may be potentially useful for prediction and monitoring of treatment response to chemoradiotherapy of sinonasal tumors. Methods One hundred and forty-three patients with sinonasal tumors, including 78 malignant tumors and 65 benign tumors and tumor-like lesions, underwent clinically used DCE-MRI. Parametric maps were obtained for quantitative parameters including K trans, kep and v e. Two radiologists reviewed these maps and measured K trans, kep and v e in the tumor tissue. Data were analyzed using independent T-test or Mann-Whitney U test analysis and receiver operating characteristic curves. Results K trans, kep and v e showed significant differences between benign and malignant tumors in the sinonasal area (P=0.000 1). The accuracy of K trans, kep and v e in differentiation between benign and malignant sinonasal tumors were 72.0%, 76.2% and 67.1%, respectively. There were significant differences in kep and v e between malignant epithelial sinonasal tumors and lymphomas (P <0.05). Using a ve value of 0.213 as the threshold value differentiated malignant epithelial tumors from lymphomas with an accuracy of 78.3%, sensitivity of 88.2%, specificity of 68.0%, positive predictive value of 66.7%, and negative predictive value of 90.9%. However, no significant difference in K trans and kep was found between malignant epithelial and non-epithelial tumors in the sinonasal area (P >0.05). Conclusions It is feasible that quantitative parameters of tumors can be derived from clinically used DCE-MRI in the sinonasal region. Preliminary findings suggest an increased value for quantitative DCE-MRI in the evaluation of sinonasal tumors in clinical practice.
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Kühn, Shafreena, Andrej Wehle, Marcus Kiehlmann e Ulrich Michael Rieger. "Patientenzufriedenheit nach geschlechtsangleichender Mastektomie in Frau-zu-Mann-transidenten Patienten – eine Analyse unter Verwendung eines modifizierten BREAST-Q-Fragebogens". Handchirurgie · Mikrochirurgie · Plastische Chirurgie 53, n. 06 (dicembre 2021): 564–71. http://dx.doi.org/10.1055/a-1640-0295.
Testo completoAbstract (sommario):
Zusammenfassung Hintergrund Die Mastektomie ist essenzieller Bestandteil der geschlechtsangleichenden Operationen in der Gruppe Frau-zu-Mann(FM)-transidenter Patienten. Einschlägige Studien zeigen eine hohe Patientenzufriedenheit in dieser Kohorte, allerdings etablierte sich bisher kein standardisiertes Verfahren zur Evaluation der Effektivität. Methoden Anhand des etablierten Breast-Q-Fragebogens entwickelten wir eine modifizierte Version unter Berücksichtigung spezifischer Fragestellungen hinsichtlich FM-transidenter Patienten. Demnach erfolgte die Anpassung aller Fragen, welche gezielt die Physiologie von Cis-Frauen adressieren. Im Sinne eines „One-Group Post-Test Only“-Designs kontaktierten wir Patienten nach stattgehabter Mastektomie im Zeitraum von 1991 bis 2017 und evaluierten die Ergebnisse des Fragebogens von insgesamt 28 Patienten. Letzterer beinhaltet 57 Fragen hinsichtlich der grundlegenden Zufriedenheit mit der Brustregion, ebenso wie spezifische Fragen zur Zufriedenheit mit dem Mamillen-Areola-Komplex und hinterfragt Themen wie Erwartungen, Selbstbewusstsein, Sexualleben und Bedauern nach erfolgter Mastektomie. Ergebnisse Insgesamt zeigte sich ein hohes Maß an Patientenzufriedenheit nach stattgehabter Mastektomie. Alle befragten Patienten würden den Eingriff wiederholen und nur wenige äußerten Bedauern. Konklusion Die Mastektomie spielt eine entscheidende Rolle hinsichtlich geschlechtsangleichender Eingriffe bei Trans-Männern und zeigt eine hohe postoperative Zufriedenheit als Ausdruck einer Lebensqualitätsverbesserung.
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Provias, J., e B. Jeynes. "The Role of the Blood-Brain Barrier in the Pathogenesis of Senile Plaques in Alzheimer’s Disease". International Journal of Alzheimer's Disease 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/191863.
Testo completoAbstract (sommario):
The accumulation of beta-amyloid [Aβ] within senile plaques [SP] is characteristic of these lesions in Alzheimer’s disease. The accumulation of Aβ42, in particular, in the superior temporal [ST] cortex may result from an inability of the blood brain barrier (BBB) to regulate the trans-endothelial transport and clearance of the amyloid. Lipoprotein receptor-related protein [LRP] and P-glycoprotein [P-gp] facilitate the efflux of Aβout of the brain, whereas receptor for advanced glycation end products [RAGE] facilitates Aβinflux. Additionally, vascular endothelial growth factor [VEGF] and endothelial nitric oxide synthase [eNOS] may influence the trans-BBB transport of Aβ. In this study we examined ST samples and compared SP burden of all types with the capillary expression of LRP, p-gp, RAGE, VEGF, and e-NOS in samples from 15 control and 15 Alzheimer brains. LRP, P-gp, RAGE, VEGF, and eNOS positive capillaries and Aβ42plaques were quantified and statistical analysis of the nonparametric data was performed using the Mann-Whitney and Kruskal-Wallis tests. In the Alzheimer condition P-gp, VEGF, and eNOS positive capillaries were negatively correlated with SP burden, but LRP and RAGE were positively correlated with SP burden. These results indicate altered BBB function in the pathogenesis of SPs in Alzheimer brains.
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Bohle, Ulrike. "Strategien und Mittel des Genderns zwischen Verfestigung und Destabilisierung von Geschlecht". Betrifft Mädchen, n. 2 (28 aprile 2020): 56–61. http://dx.doi.org/10.3262/bem2002056.
Testo completoAbstract (sommario):
40 Jahre nach Erscheinen der ersten „Richtlinien zur Vermeidung sexistischen Sprachgebrauchs“ ist ihre Notwendigkeit und Legitimität immer noch umstritten. Leitfäden zur geschlechtergerechten Sprache werden einerseits als unzulässiger Eingriff in die Sprache zurückgewiesen, andererseits wird vor einer Verfestigung normativer Geschlechtermodelle gewarnt. Entstanden sind die ersten Empfehlungen im Kontext der neuen Frauenbewegung aus Kritik an der Diskriminierung von Frauen in und durch Sprache. Feministische Sprachkritik wurde bald in der Gesetzgebung aufgegriffen (s. Stickel 1988: 333 f., Schoenthal 1989: 298 f., Kusterle 2011: 19-21 u. a.) und ist heute Teil von Gender Mainstreaming (Wetschanow 2017) – bis vor kurzem implizit gedacht als Gleichstellung von Mann und Frau. Erst das Erstarken der Trans*- und Inter*-Bewegung seit den 1990er Jahren führte zur rechtlichen Anerkennung eines dritten/unbestimmten Geschlechts (§ 22 Abs. 3 PStG). Eng verwoben mit der Frauen- wie der Schwulen-/Lesben-/Bi-/Trans-/Inter*-Bewegung ist die Entwicklung der Frauenund Geschlechterforschung und der queer studies. Im Zusammenwirken von sozialen Bewegungen, Wissenschaft und Gesetzgebung haben sich im Laufe der Jahre verschiedene Formen des Genderns entwickelt. Ziel des Beitrags ist es, die Diskussion zu systematisieren. Im ersten Schritt sollen sprach- und geschlechtertheoretische Grundpositionen skizziert werden, aus denen sich bestimmte sprachpolitische Strategien ableiten lassen. Im zweiten Schritt sollen diesen Strategien die verschiedenen Formen zugeordnet werden.
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Hahn, Britta, Imme Haubitz, Ralf Krug, Gabriel Krastl e Sebastian Soliman. "Influence of Matrix Type on Marginal Gap Formation of Deep Class II Bulk-Fill Composite Restorations". International Journal of Environmental Research and Public Health 19, n. 9 (19 aprile 2022): 4961. http://dx.doi.org/10.3390/ijerph19094961.
Testo completoAbstract (sommario):
Background: To test the hypothesis that transparent matrices result in more continuous margins of bulk-fill composite (BFC) restorations than metal matrices. Methods: Forty standardized MOD cavities in human molars with cervical margins in enamel and dentin were created and randomly assigned to four restorative treatment protocols: conventional nanohybrid composite (NANO) restoration (Tetric EvoCeram, Ivoclar Vivadent, Schaan, Liechtenstein) with a metal matrix (NANO-METAL) versus transparent matrix (NANO-TRANS), and bulk-fill composite restoration (Tetric EvoCeram Bulk Fill, Ivoclar Vivadent, Schaan, Liechtenstein) with a metal matrix (BFC-METAL) versus transparent matrix (BFC-TRANS). After artificial aging (2500 thermal cycles), marginal quality was evaluated by scanning electron microscopy using the replica technique. Statistical analyses were performed using the Mann–Whitney U-test and Wilcoxon test. The level of significance was p < 0.05. Results: Metal matrices yielded significantly (p = 0.0011) more continuous margins (46.211%) than transparent matrices (27.073%). Differences in continuous margins between NANO (34.482%) and BFC (38.802%) were not significant (p = 0.56). Matrix type did not influence marginal gap formation in BFC (p = 0.27) but did in NANO restorations (p = 0.001). Conclusion: Metal matrices positively influence the marginal quality of class II composite restorations, especially in deep cavity areas. The bulk-fill composite seems to be less sensitive to the influence of factors such as light polymerization and matrix type.
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Slotkowski, Rebecca, Matthew Van Ormer, Anum Akbar, Olivia Paetz, Taija Hahka, Maranda Thompson, Alyssa Freeman et al. "Retinol and Pro-Vitamin A Carotenoid Nutritional Status during Pregnancy Is Associated with Newborn Hearing Screen Results". Nutrients 15, n. 4 (4 febbraio 2023): 800. http://dx.doi.org/10.3390/nu15040800.
Testo completoAbstract (sommario):
The prenatal period is critical for auditory development; thus, prenatal influences on auditory development may significantly impact long-term hearing ability. While previous studies identified a protective effect of carotenoids on adult hearing, the impact of these nutrients on hearing outcomes in neonates is not well understood. The purpose of this study is to investigate the relationship between maternal and umbilical cord plasma retinol and carotenoid concentrations and abnormal newborn hearing screen (NHS) results. Mother–infant dyads (n = 546) were enrolled at delivery. Plasma samples were analyzed using HPLC and LC–MS/MS. NHS results were obtained from medical records. Statistical analysis utilized Mann–Whitney U tests and logistic regression models, with p ≤ 0.05 considered statistically significant. Abnormal NHS results were observed in 8.5% of infants. Higher median cord retinol (187.4 vs. 162.2 μg/L, p = 0.01), maternal trans-β-carotene (206.1 vs. 149.4 μg/L, p = 0.02), maternal cis-β-carotene (15.9 vs. 11.2 μg/L, p = 0.02), and cord trans-β-carotene (15.5 vs. 8.0 μg/L, p = 0.04) were associated with abnormal NHS. Significant associations between natural log-transformed retinol and β-carotene concentrations and abnormal NHS results remained after adjustment for smoking status, maternal age, and corrected gestational age. Further studies should investigate if congenital metabolic deficiencies, pesticide contamination of carotenoid-rich foods, maternal hypothyroidism, or other variables mediate this relationship.
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Passang, Stanzin, Susanne Schmidt e Marcus Nüsser. "Topographical Impact on Snow Cover Distribution in the Trans-Himalayan Region of Ladakh, India". Geosciences 12, n. 8 (20 agosto 2022): 311. http://dx.doi.org/10.3390/geosciences12080311.
Testo completoAbstract (sommario):
This article presents the distribution of seasonal snow cover in the Trans-Himalayan region of Ladakh over the observation period of 2000–2019. Seasonal snow cover area and duration have been monitored and mapped based on the MODIS Normalised Difference Snow Index (NDSI). Using different MODIS cloud removal algorithms, monthly mean cloud-covered areas have been reduced to 3%. Pixel-wise approaches using Mann–Kendall (MK) and Sen’s slope trend tests allow to assess seasonal and annual trends of snow cover days (SCD) and snow cover area (SCA) across seven delineated subregions of Ladakh. Analyses include the impact of topographical parameters (elevation, slope, aspect). Overall, the mean annual SCA amounts to 42%, varying from 15% in August to 71% in February. However, large differences of SCA have been detected between and within subregions. The trend analysis of SCA shows a non-significant, slight increase for summer as well as for the entire year and a decrease for spring and winter seasons. The SCD trend analysis indicates more pixels with a significant increase than a decrease. In total, 12% of all pixels show an increasing trend in summer, 6% over the entire year, 3% in autumn, and 2% in spring and winter, whereas less than 2% of all pixels show a decreasing trend in all seasons. The results are important for regional irrigated agricultural production and freshwater supply in the context of climate change.
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Jha, S., V. K. Sehgal, R. Raghava e M. Sinha. "Trend of standardized precipitation index during Indian summer monsoon season in agroclimatic zones of India". Earth System Dynamics Discussions 4, n. 1 (18 aprile 2013): 429–49. http://dx.doi.org/10.5194/esdd-4-429-2013.
Testo completoAbstract (sommario):
Abstract. Standardized precipitation index (SPI) was computed with CRU TS3.0 gridded 0.5 × 0.5° monthly precipitation dataset for each of the 14 mainland agroclimatic zones (ACZs) of India for individual months (June, July, August and September) and season (JJAS) of summer monsoon for 56 yr (1951–2006). Mann Kendall Trend Test with the representative SPI of the ACZs shows that only six out of 14 mainland ACZs have a significant trend during summer monsoon. Trans-Gangetic plain significantly gains wetness during the month of June. West coast plain and hill has a typical feature of significant increasing trend of wetness during June and increasing dryness during July. In general Upper Gangetic plain, Middle Gangetic plain, Central plateau and hill and Eastern plateau and hill have a significantly increasing drying trend during the whole duration of summer monsoon season.
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Lee, Alexander. "My Secret Book. Francesco Petrarca.Ed. and trans. Nicholas Mann. The I Tatti Renaissance Library 72. Cambridge, MA: Harvard University Press, 2016. xviii + 284 pp. $29.95." Renaissance Quarterly 72, n. 4 (2019): 1422–23. http://dx.doi.org/10.1017/rqx.2019.383.
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Devaux, Celine, Xiaoduan Weng, Louise Robin, Harold J. Olney, Gilbert Cornut e Denis Soulières. "Prevalence of Frequent α-Globin Gene Deletions in Neonates with HbH in Cord Blood." Blood 106, n. 11 (16 novembre 2005): 3817. http://dx.doi.org/10.1182/blood.v106.11.3817.3817.
Testo completoAbstract (sommario):
Abstract Introduction: Increasing multiethnicity is likely to make α-thalassemia minor more prevalent in Western metropolitan areas. It also increases the probability of finding newborns with Hemoglobin H disease or hydrops foetalis. Therefore, there is a need to implement screening methods to detect α-thalassemia at birth. Screening should also identify patients and families with specific requirements in genetic counselling. The goal of the present study is to evaluate the value of HbH measurement in cord blood to identify patients with α-globin deletions and patients with genotypes at risk that should be directed towards genetic counselling. Methods: A universal neonatal screening for hemoglobinopathies and thalassemia has been performed at our institution since 2002. Between October 2002 and July 2005, hemoglobin HPLC (High Performance Liquid Chromatography, Bio-Rad Variant II)) analysis performed on ombilical cord blood identified 123 newborns with hemoglobin H (HbH). Subsequently, DNA samples were analysed by m-PCR to detect the most common alpha-globin gene deletions:-α 3.7, -α 4.2, -α 20.5, -- SEA,-- FIL, -- THAI, -- MED. Groups were formed based on the genotype (1 deletion, 2 deletions, 2 deletions in cis, 2 deletions in trans) The mean level of HbH was calculated for each genotype and group. Student t-test was used to compare the level of HbH between the different groups. Due to the heterogeneity of the group populations, a Mann-Whitney test was also used to corroborate results obtained with t-test. Results: At least one α-globin gene deletion was observed in 90.2% of cases.(95%I.C: 83.5%-95.0%). Comparison between the groups based on the number of α-globin gene deletion and their allelic distribution allowed identification of significant differences in the HbH levels. Results were similar with Mann-Whitney (data not shown).Comparisons are presented in Table 1. HbH levels for the specific genotypes are presented in Figure 1. Conclusion: Hemoglobin HPLC analysis performed on umbilical cord blood allows rapid and efficient detection of HbH and highly predicts the presence of common α-globin gene deletions. Moreover a significant correlation is demonstrated between the levels of HbH and the presence of an α-thalassemic genotype. HbH level seems to correlate positively with the clinical severity of the genotype. However, a discriminate level of HbH could not be established to identify patients specifically requiring genotyping and genetic counselling. Further testing is necessary to evaluate the causes of HbH expression when there is no α-globin gene deletion. Genotype and HbH level Genotype and HbH level Mean HbH level (% of total hemoglobin) deletions/allelic distribution HbH level (means) HbH level (range) level of significance 1 deletion 2.10 1.4–5.9 2 deletions 6.96 4.0–12.6 p<0.001 1 deletion 2.10 1.4–5.9 2 deletions trans 6.50 4.0–9.2 p<0.001 1 deletion 2.10 1.4–5.9 2 deletions cis 10.6 7.3–12.6 p<0.01 2 deletions trans 6.50 4.0–9.2 2 deletions cis 10.6 7.3–12.6 p<0.001
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Agbley, Daniel, Henry Holdbrook-Smith e Yao Ahonon. "A comparative evaluation of the efficacy between skeletal traction and skin traction in pre-operative management of femur shaft fractures in Korle Bu Teaching Hospital". Ghana Medical Journal 54, n. 3 (30 settembre 2020): 146–50. http://dx.doi.org/10.4314/gmj.v54i3.4.
Testo completoAbstract (sommario):
Objectives: This study is to compare the outcomes of pre-operative skeletal and skin traction in adult femoral shaft fractures awaiting surgical fixation within two weeks of presentation to the Accident Center of Korle Bu Teaching Hospital.Methods: This study was a clinical trial on 86 recruited patients with closed femoral shaft fractures sustained within 24 hours of presentation grouped into 2 groups. Descriptive and inferential statistics comprising frequency, percentage, Chi-square, independent sample t-test and Mann-Whitney U test were used in analysing the data.Results: Of the total number of patients involved in the study, 74% (n=64) were males and 26% (n=22) were females with a mean age of 39.49 (SD ±15). There was no statistically significant difference in the mean visual analogue scale (VAS) pain assessment between the Skin traction group and Trans-tibia skeletal traction group after traction. With regards to complications, the difference between the Skin traction group and the Skeletal traction group was statistically significant (P=0.001). Moreover, the mean blood loss compared with the open type of reduction in the Transtibia skeletal traction group was significantly less than the Skin traction group (p=0.000).Conclusion: This study has shown that both Skeletal traction and Skin traction were equally effective in controlling pre-operative pain in adult patients with femoral shaft fractures and does not affect intra-operative blood loss and postoperative management. Therefore, pre-operative Skin traction can be considered a useful and cost-effective method of maintaining alignment and pain relief in adult femoral shaft fractures.Keywords: Skin traction, Trans-tibia skeletal, reamed Intramedullary nailing, Intra-operative blood loss, Visual Analogue ScaleFunding: Personal Funding
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Fogel, Joshua A. "Philosophy and Politics in China: The Controversy over Dialectical Materialism in the 1930s. By Werner Meissiner, trans. Richard Mann. Hurst & Company: London, 1990. Pp. VIII, 230." Modern Asian Studies 27, n. 2 (maggio 1993): 448–51. http://dx.doi.org/10.1017/s0026749x00011574.
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Agostini, Clarissa de Oliveira, Ester Zoche, Rafaela da Silveira Corrêa, Eunice Beatriz Martin Chaves, Helena von Eye Corleta e Vera Lúcia Bosa. "Contribution of Ultra-processed Food to the Daily Food Intake of HIV-positive and HIV-Negative Women during Pregnancy". Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics 41, n. 10 (3 settembre 2019): 588–96. http://dx.doi.org/10.1055/s-0039-1695738.
Testo completoAbstract (sommario):
Objective To assess the daily dietary intake and energy contribution of ultra-processed foods among women who are positive and negative for the human immunodeficiency virus (HIV) during pregnancy. Methods This case–control study included 77 HIV-positive and 79 HIV-negative puerperal women between 2015 and 2016. The socioeconomic and maternal demographic data were assessed, and a food frequency questionnaire (FFQ) adapted for pregnant women was applied. The Fisher exact test and the Mann-Whitney test were applied to detect differences between the groups. Linear regression was used to assess the associations between the intake of ultra-processed food and energy, macro- and micronutrients, with values of p < 0.05 considered significant. Results The HIV-positive group was older (p < 0.001) and had lower income (p = 0.016) and level of schooling (p < 0.001) than the HIV-negative group. Both groups presented similar average food intake: 4,082.99 Kcal/day and 4,369.24 Kcal/day for the HIV-positive and HIV-negative women respectively (p = 0.258).The HIV-positive group consumed less protein (p = 0.048), carbohydrates (p = 0.028) and calcium (p = 0.001), and more total fats (p = 0.003). Ultra-processed foods accounted for 39.80% and 40.10% of the HIV-positive and HIV-negative groups' caloric intake respectively (p = 0.893). The intake of these foods was associated with a higher consumption of carbohydrates (p < 0.001), trans fat (p = 0.013) and sodium (p < 0.001), as well as lower protein (p < 0.001) and fiber intake (p = 0.022). Conclusion These findings demonstrate that the energy consumption and ultra-processed food intake were similar in both groups, which reinforces the trend toward a high intake of ultra-processed food in the general population. The intake of ultra-processed food was positively associated with the consumption of carbohydrates, trans fat and sodium, and negatively associated with the consumption of protein and fiber.
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Datta, D., I. Harris, B. Heller, J. Howitt e R. Martin. "Gait, cost and time implications for changing from PTB to ICEX®sockets". Prosthetics and Orthotics International 28, n. 2 (agosto 2004): 115–20. http://dx.doi.org/10.1080/03093640408726696.
Testo completoAbstract (sommario):
The ICEX®system (Ossur, Iceland), allows a socket to be manufactured directly onto the stump and is thought to provide improved comfort due to better pressure distribution whilst being easier to fit and manufacture.The aims of this project were to a) compare gait performance by measuring several gait characteristics, b) compare production and fitting times, c) investigate financial implications and d) attempt to gauge the amputees’ subjective opinions of socket comfort.A randomised, controlled trial was conducted on 27 trans-tibial amputees with an existing patellar tendon bearing (PTB) socket on the Endolite™ system (Chas A. Blatchford, UK). Twenty one (21) subjects completed the study. Of these, 10 in the control group received new PTB sockets while 11 in the experimental group received ICEX®.Gait analysis wearing existing sockets was performed and kinetic data obtained from a force plate. This was repeated with the new sockets after a 6 week period of adjustment. Mann-Whitney tests were used in statistical evaluations with a significance level of 5%. Subjects were asked to score their prosthesis for comfort using the Socket Comfort Score (Hanspal et al., 2003) and the frequency of visits for socket adjustments over a three-month period post-delivery of the sockets was recorded.This study demonstrates no significant difference in any of the gait parameters measured. Though the time required to manufacture a PTB prosthesis was found to be considerably longer than the ICEX®, the overall cost for producing the ICEX®was significantly greater. Subjects showed only minor comfort preference for the ICEX®design and there was no significant difference in the mean number of visits for socket adjustments.In view of the considerable additional cost of providing ICEX®and the lack of evidence of improvement in any parameter tested, the routine provision of ICEX®prostheses to unselected trans-tibial amputees cannot be recommended.
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García-Manzano, Roberto Armando, Sergio García-Méndez, Edgar Gaytán-Escobar, Victor Manuel Flores-Carrillo e Sergio Vásquez-Ciriaco. "Comparación de los desenlaces trans y postquirúrgicos de pacientes tratados con nefrectomía laparoscópica contra abierta en un hospital de tercer nivel". Revista Mexicana de Urología 81, n. 3 (30 luglio 2021): 1–12. http://dx.doi.org/10.48193/revistamexicanadeurologa.v81i3.774.
Testo completoAbstract (sommario):
Objetivo: Comparar los desenlaces trans y postquirúrgicos (tiempo quirúrgico, volumen de sangrado transoperatorio, y días de estancia intrahospitalaria) en pacientes sometidos a nefrectomía por abordaje abierto contra abordaje laparoscópico.
Material y métodos: Análisis retrospectivo, observacional y analítico; incluimos variables demográficas, tipo de patología, tipo de abordaje quirúrgico y desenlaces con estadística descriptiva (medidas de tendencia central y de dispersión) y análisis comparativo entre grupos (x2 y prueba de U de Mann-Whitney), consideramos diferencias estadísticamente significativas cuando p≤0.05.
Resultados: Analizamos expedientes de 66 mujeres (65.3 %) y 35 hombres (34.7%); 66 (65.3%) tenían patología benigna y 35 (34.7%) con patología maligna. Se realizó nefrectomía abierta a 67 (66.3%) pacientes y nefrectomía laparoscópica a 34 (33.7%) pacientes. No hubo diferencias en cuanto al género, edad, tipo de patología y tiempo quirúrgico. El volumen de sangrado y los días de estancia intrahospitalaria fueron significativamente menores en pacientes con nefrectomía laparoscópica (p=0.001 y p=0.041, respectivamente).
Limitaciones del estudio o implicaciones: Estudio retrospectivo.
Originalidad o valor: Primer reporte que describe los resultados postquirúrgicos en nefrectomías realizadas por abordaje abierto y laparoscópico en el sur del país.
Conclusiones: Nuestros resultados son consistentes con la evidencia actual en cuanto a los beneficios de la nefrectomía laparoscópica sobre la nefrectomía abierta.
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Sunarti, Sunarti, Edy Fachrial, Urip Harahap, Delyuzar Delyuzar, Tri Widyawati e Lokot Donna Lubis. "Hepatoprotective effect of red ginger rhizome extract in deep frying oil-fed male wistar rats". Universa Medicina 36, n. 3 (8 dicembre 2017): 228. http://dx.doi.org/10.18051/univmed.2017.v36.228-235.
Testo completoAbstract (sommario):
BACKGROUND<br />Non-alcoholic steatohepatitis (NASH) is a chronic liver disease associated with increased free fatty acids, trans fatty acids and free radical compounds due to the consumption of deep frying oil (DFO). Ginger has hypolipidemic and antioxidant properties, and acts as an insulin sensitizer. The present study was conducted to evaluate the hepatoprotective effect of an ethanol extract of Zingiber officinale Roxb var rubrum (EEZO) in DFO-fed male Wistar rats.<br /><br />METHODS<br />A study of experimental design was conducted involving 24 non-alcoholic steatohepatitis (NASH) male Wistar rats that were randomly divided into 4 groups. Group K1 (control) was given DFO-3 (3 times heated DFO) at a dose of 10 ìl/g BW/day. The treatment groups (P1, P2, P3) were given DFO-3 and red ginger rhizome extract at doses of 100, 200, and 400 mg/kg BW orally for 30 days. The histopathology examination assessed fatty degeneration, and degree of fibrosis. The data were analyzed with the Kruskal-Wallis and Mann-whitney test.<br /><br />RESULTS <br />The Kruskal-Wallis test showed that fatty degeneration (steatosis, lobular inflammation, hepatocyte ballooning and NASH) were significantly different among the four groups (p<0.05). Mann-Whitney test proved that fatty degeneration was not significantly different between control and treatment groups (p>0.05).<br /><br />CONCLUSION<br />Deep frying oil increased fatty degeneration and NASH, and none of red ginger rhizome extract doses was able to inhibit fatty degeneration significantly. For the future research it is intended to prolong the induction time and the administration of red ginger rhizome extract.
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Kaban, Karmila, e Sunarti Sunarti. "EKSTRAK RIMPANG KUNYIT (Curcuma longa Linn) MENURUNKAN PENYAKIT PERLEMAKAN HATI NON-ALKOHOLIK". BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) 5, n. 2 (21 gennaio 2019): 123–30. http://dx.doi.org/10.31289/biolink.v5i2.1800.
Testo completoAbstract (sommario):
The use of recycled frying oil or deep frying oil (DFO) lead to increase in free fatty acid, trans fatty acid and free radical compound. It can cause non-alcoholic fatty liver disease (NAFLD). a chronic liver disease cause the risk for cirrhosis and heart cancer. However, there is no medicine for preventing the disease. The present study was conducted to investigate the turmeric reduces steatosis hepatocyte of male Wistar rat NAFLD model. The study used experimental randomize post-test only control group design. The 24 samples consist of four treatment groups. Group I (control): normal diet + DFO (10 μl/g/day on 6 times heating), Group II, III and IV: normal diet + DFO (10 μl/g/day on 6 times heating)+ turmeric Extract (100, 200, and 400 mg/kg/day) by given for 30 days through oral induction. The results of Kruskal-Wallis test showed a significant difference between the four treatment groups (P= 0.019) .The results of Mann-Whitney test showed significant difference in steatosis hepatocyte between the control group (P1) and treatment group(P3) the dose of 200 mg/kg BW. This suggests that a dose of 200 mg/kg BW is an effective dose in decreasing hepatocyte steatosis.
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Mulyaningsih, Sri, e Agustriyanata Vieri Ansharullah. "Potensi Ekstrak Lengkuas Merah (Alpinia purpurata K. Schum) sebagai Cairan Pencuci Buah". Jurnal Sains dan Kesehatan 4, SE-1 (31 dicembre 2022): 48–54. http://dx.doi.org/10.25026/jsk.v4ise-1.1689.
Testo completoAbstract (sommario):
Mencuci buah merupakan kebiasaan yang dilakukan sebelum mengkonsumsi buah. Pencucian buah dilakukan dengan air atau cairan lain untuk membersihkan kotoran atau bakteri yang menempel. Ekstrak lengkuas merah dilaporkan mempunyai aktivitas antibakteri. Penelitian ini bertujuan untuk meneliti ekstrak etanol rimpang lengkuas merah dalam menginaktivasi jumlah bakteri total dan Escherichia coli serta mengetahui potensinya sebagai cairan pencuci pada buah. Analisis kandungan ekstrak dilakukan dengan menggunakan kromatografi gas spektroskopi massa. Ekstrak diperoleh dengan maserasi menggunakan etanol 96%. Ekstrak dengan konsentrasi 0,5%, 1%, dan 5% selanjutnya digunakan untuk merendam buah takokak selama 5 menit. Penentuan jumlah bakteri menggunakan metode total plate count (TPC) pada media plate count agar (PCA) dan eosin methylene blue (EMB) Agar. Data dianalisis statistik menggunakan uji Kruskal-Wallis dan Mann-whitney. Hasil GCMS komponen ekstrak lengkuas merah merupakan golongan fenol, ester, asam lemak dan minyak atsiri seperti eugenol, trans-kariofilen, dan b-farnesen. Jumlah bakteri total dari air rendaman buah takokak dari ketiga konsentrasi tidak berbeda signifikan dengan kontrol negatif dan kontrol positif. Sementara penurunan jumlah bakteri E. coli akibat perlakuan ekstrak rimpang laos merah berbeda signifikan dibandingkan dengan kontrol negatif maupun kontrol positifnya. Kesimpulannya, ekstrak rimpang lengkuas merah berpotensi sebagai cairan pencuci mengurangi jumlah E. coli, tetapi kurang efektif menurunkan jumlah bakteri total.
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Agustina Risvianti, Eka, Vianty Mutya Sari, Wiwin Widayanti e Nisa Rizki Nurfita. "The Effectiveness of Lavender Aromatherapy on Pain Scores for Post Sectio Caesarea in The Puskesmas Sukahaji Majalengka Regency". Jurnal Medisci 1, n. 3 (16 dicembre 2023): 134–41. http://dx.doi.org/10.62885/medisci.v1i3.140.
Testo completoAbstract (sommario):
Sectio Caesarea (SC) deliveries have a higher risk because the surgery is performed by opening the abdominal wall and uterine wall or a trans-abdominal incision of the uterus. Patients with SC will feel pain. Therefore, pain management will be more effective when combined with non-pharmacological therapy. One of the non-pharmacological therapies that can be applied is aromatherapy. The purpose of this study was to determine the effectiveness of lavender aromatherapy on the pain score of post sc in the area of Puskesmas Sukahaji Kab Majalengka Tahun 2023. The design used is a quasi-experimental with one shoot only, the number of samples is 15 intervention groups and 15 control groups, the sampling technique uses purposive sampling. The results of data analysis obtained an average value in the intervention group of 2.60 and the control group of 7.33. The results of the Mann Whitney test. Research result obtained a value of p = 0.000 or p <0.05 meaning that lavender aromatherapy is effective against post SC maternal pain scores. Lavender aromatherapy is effective for post SC maternal pain scores in the Sukahaji Health Center area in 2023. It is hoped that it can be used as a complementary therapy in pain management so that it becomes a holistic and comprehensive treatment therapy
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Javadi, Vahideh, Farzaneh Ahmadi, Leila Salek Ebrahimi, Ehsan Fakoor, Mohsen Dadashi e Elnaz Mousavi. "Evaluation of cognitive, emotional, and social trans-diagnostic structures in severe predictions in adolescents with and without sub-clinical symptoms of emotional disorders". Medical Journal of Tabriz University of Medical Sciences 44, n. 4 (11 ottobre 2022): 343–50. http://dx.doi.org/10.34172/mj.2022.039.
Testo completoAbstract (sommario):
Background. The purpose of this study was to compare the meta-diagnostic constructs of emotion regulation, negative repetitive thoughts, cognitive flexibility, and social adjustment in two groups of adolescents with and without preclinical symptoms of emotional disorders. Methods. The samples of this cross-sectional and comparative research includes included 140 teenagers who were divided into two groups. Adolescents were divided into two groups based on the diagnostic interview and DASS-21 questionnaire. Statistical analysis of the data was done using the Mann-Whitney and Chi- 2 square tests. Results. Cognitive flexibility and emotion regulation in the group of healthy adolescents was significantly higher than the group of adolescents with preclinical symptoms. However, the level of social adjustment was not significantly different between the two groups of adolescents with preclinical symptoms and healthy adolescents. Conclusion. The significant difference between the two groups of teenagers in meta-diagnostic structures shows the importance of these factors in the process of prevention, diagnosis, and treatment of emotional disorders and symptoms such as anxiety and depression. Practical Implications. Considering the existence of significant differences in the two groups of adolescents in meta-diagnostic cognitive and emotional structures, effective measures can be taken in order toto prevent the complete clinical manifestation of emotional disorders; . As a result of these measures, he took an important step can be taken in to reducing reduce the financial, psychological, and social costs caused by these disorders
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Paudel, Basanta, Zhaofeng Wang, Yili Zhang, Mohan Kumar Rai e Pranesh Kumar Paul. "Climate Change and Its Impacts on Farmer’s Livelihood in Different Physiographic Regions of the Trans-Boundary Koshi River Basin, Central Himalayas". International Journal of Environmental Research and Public Health 18, n. 13 (3 luglio 2021): 7142. http://dx.doi.org/10.3390/ijerph18137142.
Testo completoAbstract (sommario):
The impact of climate change on farmers’ livelihoods has been observed in various forms at the local and regional scales. It is well known that the Himalayas region is affected by climate change, as reflected in the basic knowledge of farmers in the region. A questionnaire-based survey involving a total of 747 households was conducted to gather information on climate change and its impact, where the survey addressed four physiographic regions of the trans-boundary Koshi River Basin (KRB). Moreover, climatic data were used to calculate climatic trends between 1980 and 2018. The Mann–Kendall trend test was performed and the Sen’s slope calculated to analyze the inter-annual climatic trends over time. The survey noted that, for the basin, there was an increase in temperature, climate-induced diseases of crops, an increase in the frequency of pests as well as drought and floods and a decrease in rainfall, all which are strong indicators of climate change. It was perceived that these indicators had adverse impacts on crop production (89.4%), human health (82.5%), livestock (68.7%) and vegetation (52.1%). The observed climatic trends for all the physiographic regions included an increasing temperature trend and a decreasing rainfall trend. The rate of change varied according to each region, hence strongly supporting the farmers’ local knowledge of climate change. The highest increasing trend of temperature noted in the hill region at 0.0975 °C/a (p = 0.0002) and sharpest decreasing trend of rainfall in the mountain region by −10.424 mm/a (p = 0.016) between 1980 and 2018. Formulation of suitable adaptation strategies according to physiographic region can minimize the impact of climate change. New adaptation strategies proposed include the introduction of infrastructure for irrigation systems, the development of crop seeds that are more tolerant to drought, pests and disease tolerance, and the construction of local hospitals for the benefit of farming communities.
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Shimizu, Naomi, Hideaki Bujo, Meizi Jiang, Keigo Nishii, Emiko Sakaida, Chikako Ohwada, Masahiro Takeuchi et al. "Soluble LR11, GCSF−induced Migration Regulator from Myeloid Cells, Is Highly Increased in Chronic Myeloid Leukemia". Blood 124, n. 21 (6 dicembre 2014): 4961. http://dx.doi.org/10.1182/blood.v124.21.4961.4961.
Testo completoAbstract (sommario):
Abstract Introduction: Chronic myeloid leukemia (CML) is characterized by the myeloproliferative clonal hyperplasia caused by the protein product of the BCR-ABL fusion gene. However, the mechanism underlying the release of increased numbers of myeloid cells from bone marrow (BM) to circulation which causes the accompanied remarkably high count of peripheral white blood cells (WBC) has not been fully elucidated. We have recently reported that G-CSF treatment induced the shedding of an LDL receptor family member LR11 (also called SorLA or SORL1) from myeloid cells, and the released soluble receptor accelerate the trans-endothelial migration of myeloid cells in cooperation with an endothelial activator, tumor necrosis factor-a (TNF-a) (Shimizu et al Ann Hematol 2014). Another group showed that the levels of TNF- a and G-CSF production by CML stem/progenitor cells were increased in the BM of CML. Thus, we hypothesized that the expanded mobilization of peripheral cells in CML is caused by the abnormally induced shedding activity which releases the two soluble key molecules for the migration of clonally expanded cells from BM to peripheral blood. Based on these backgrounds, we examined soluble LR11 levels in the BM of CML patients. Materials and methods: We analyzed 11 patients (comprising three CML, six acute myeloid leukemia (AML) and two immune thrombocytopenia (ITP)), who underwent bone marrow aspiration at the time of diagnosis in Chiba University Hospital between 2011 and 2012. We measured the levels of sLR11 in supernatants of BM by an ELISA method. We also examined the levels of TNF-a and MMP9 in some patients. Then we compared with clinical data including WBC and total nuclear cell count (TNC) of BM. Results: sLR11 levels of supernatant of BM in CML patients were significantly higher than AML patients (134.5+-215.7 ng/ml vs 15.0+-46.1 ng/ml, p=0.0389, Mann-Whitney test, Figure 1). The levels of two ITP patients were 14.8, 14.2 ng/ml respectively. There was no significant correlation between TNC and the levels of sLR11 (p=0.4386) in all patients. However, the WBC counts in CML patients (53,400+-60,253/ml) were slightly higher than AML patients (2970+-34,624/ml) (p=0.1967, Mann-Whitney test, Figure 2). We next evaluated myeloid TNF-a and MMP9 levels in patients with CML or other hematological malignancy). A CML patient revealed remarkably higher levels of TNF- a (16.8 pg/ml), and also MMP9 (22,000 pg/ml), compared with other hematological diseases. Conclusions: soluble LR11 levels were largely increased in the BM of patients with CML. Considering that the myeloid TNF-a level was increased in a case among them, the increased soluble LR11 in BM may induce myeloid cell release from BM into peripheral blood through the cooperative activation of trans-endothelial migration in cooperation with TNF-a. Figure 1. The levels of sLR11 in BM in patients with CML and AML. (p=0.0389) Figure 1. The levels of sLR11 in BM in patients with CML and AML. (p=0.0389) Figure 2. The WBC count in the patients, CML and AML. (p=0.1967) Figure 2. The WBC count in the patients, CML and AML. (p=0.1967) Disclosures No relevant conflicts of interest to declare.
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Grohmann, Raquel Margiotte, Vivian Macedo Gomes Marçal, Isabela César Corazza, Alberto Borges Peixoto, Edward Araujo Júnior e Luciano Marcondes Machado Nardozza. "Maternal Blood Fatty Acid Levels in Fetal Growth Restriction". Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics 45, n. 03 (marzo 2023): 127–33. http://dx.doi.org/10.1055/s-0043-1768455.
Testo completoAbstract (sommario):
Abstract Objective: To assess the maternal blood levels of fatty acids (FAs) in pregnancies with fetal growth restriction (FGR). Methods: This prospective cross-sectional study included pregnant women with gestational age between 26 and 37 + 6 weeks with FGR and appropriate for gestational age (AGA) fetuses. The levels of saturated, trans, monounsaturated, and polyunsaturated FAs were measured using centrifugation and liquid chromatography. The Student's t-test, Mann–Whitney test, and general linear model, with gestational age and maternal weight as covariants, were used to compare FA levels and the FGR and AGA groups. The Chi-square was used to evaluate the association between groups and studied variables. Results: Maternal blood sample was collected from 64 pregnant women, being 24 FGR and 40 AGA. A weak positive correlation was found between the palmitoleic acid level and maternal weight (r = 0.285, p = 0.036). A weak negative correlation was found between the gamma-linoleic acid level and gestational age (r = − 0.277, p = 0.026). The median of the elaidic acid level (2.3 vs. 4.7 ng/ml, p = 0.045) and gamma-linoleic acid (6.3 vs. 6.6 ng/ml, p = 0.024) was significantly lower in the FGR than the AGA group. The palmitoleic acid level was significantly higher in the FGR than AGA group (50.5 vs. 47.6 ng/ml, p = 0.033). Conclusion: Pregnant women with FGR had lower elaidic acid and gamma-linoleic acid levels and higher palmitoleic acid levels than AGA fetuses.
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Гаин, М. Ю., С. В. Шахрай e Ю. М. Гаин. "Laser Coagulation through a Wound – Method of Surgical Treatment of Pilonidal Sinus Abscess: Randomized Clinical Trial". Хирургия. Восточная Европа, n. 3 (20 novembre 2020): 181–95. http://dx.doi.org/10.34883/pi.2020.9.3.016.
Testo completoAbstract (sommario):
Цель. Изучить результаты чрезраневой лазерной коагуляции абсцедирующей пилонидальной кисты, провести их сравнительную оценку с результатами традиционного метода санации абсцесса.Материалы и методы. В проспективное исследование отобрано 80 пациентов с абсцедирующими пилонидальными кистами, которые были слепо распределены на две группы (по 40 в каждой) методом простой рандомизации.Пациентам в группе А после вскрытия и дренирования абсцесса на 2-е сутки выполнена лазерная коагуляция полости абсцесса и кисты под местной анестезией. Пациентам группы В (контроль) также выполнялась санация абсцесса, но без лазерной операции. Группы были однородны по полу, возрасту, тяжести заболевания. Через 1 месяц, 1 год было выполнено ультразвуковое исследование крестцово-копчиковой области.Результаты и обсуждение. Средние сроки заживления ран оказались сопоставимы (p=0,8061, z=–0,2459 Mann – Whitney U-test). У 7,5% пациентов в группе В через месяц выявлен вторичный свищ, что позднее потребовало иссечения кисты. Применение лазерной коагуляции пилонидальной кисты достоверно не ухудшало состояние пациентов. Отсутствовали статистически значимые различия при сравнении групп по стационарному койко-дню (p=0,1586, z=1,4097), длительности нетрудоспособности (p=0,2092, z=1,2557 Mann – Whitney U-test). Выявлены преимущества группы А по частоте ремиссии заболевания через месяц и 1 год после начала лечения (Chi-square, p=0,0009, p=0,001). При морфометрии, эхоскопии через год наличие инфильтрата без жидкостных структур и воспаления в основной группе было выявлено в 5% наблюдений, в контрольной – в 22,5%.Заключение. Метод лазерной коагуляции полости абсцесса и пилонидальной кисты обладает преимуществом по сравнению с методом санации абсцесса по частоте ремиссии заболевания в контрольные сроки до 1 года. Существует необходимость дальнейших исследований, изучения отдаленных результатов и дискуссии по вопросу хирургической тактики. Purpose. To study the results of trans-wound laser coagulation of pilonidal sinus abscess, to perform its comparative assessment with the results of abscess incision.Materials and methods. 80 patients with pilonidal sinus abscess were selected for the study. They were blindly distributed into 2 groups (40 in each) by simple randomization.Patients in the group A were subjected to laser coagulation of abscess and sinus cavities under local anesthesia after abscess incision and drainage on the day 2. Group B (control) patients were also subjected to abscess incision, but without laser. The groups were homogeneous by sex, age, severity. In 1 month, 1 year, ultrasound examination of sacral area was performed.Results and discussion. The average wound healing terms were comparable (p=0.8061, z=–0.2459 Mann – Whitney U-test). 7.5% of patients in the group B had fistula in 1 month, which required excision. The use of laser did not significantly worsen patient’s condition. There were no statistically significant differences in the hospital term-stay comparison (p=0.1586, z=1.4097), disability duration (p=0.2092, z=1.2557 Mann – Whitney U-test). The advantages of the group A in the recovery rate in 1 month, 1 year after the start of treatment were revealed (Chi-square, p=0.0009, p=0.001). After ultrasound, the infiltration without liquid and inflammation in the group A were detected in 5% of patients, in the group B – 22.5%.Conclusion. The method of pilonidal sinus laser coagulation has an advantage over the method of abscess incision in terms of disease recovery rate in the control terms of 1 year. There is the need for further research, study of remote results, and discussion about surgical tactics.
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Ellis, Henry B., Nathan Boes, Parker Mitchell, Charles Wyatt e Philip L. Wilson. "Can Combined Trans-physeal and Lateral Extra-Articular Pediatric ACL Reconstruction Techniques Be Employed to Reduce ACL Re-Injury While Allowing for Growth?" Orthopaedic Journal of Sports Medicine 7, n. 7_suppl5 (luglio 2019): 2325967119S0033. http://dx.doi.org/10.1177/2325967119s00332.
Testo completoAbstract (sommario):
Objectives: To describe outcomes, including failure rates, following a pediatric ACL reconstruction (ACLR) employing combined trans-physeal technique with hamstring autograft (TPH) and a hybrid extra-articular technique using iliotibial band autograft (ITB). Methods: Consecutive skeletally immature patients undergoing combined TPH/ITB ACLR from 1/2012 to 4/2017 were reviewed. With the goal of decreasing ACL graft re-injury in this high-risk group; this technique employed anterior-medial portal drilling for TPH, with an extra-osseous femoral ITB technique and intra-articular combined TPH/ITB grafts fixed within the tibial bone tunnel (Figure 1). Inclusion required a minimum 12 months follow up; exclusions were prior knee surgery and multi-ligamentous injury. Demographics, bone-age (hand), standing alignment XR for growth and mechanical axis grade, and PROs were documented. T-tests, Mann-Whitney tests, and Spearman’s correlation coefficients were employed. Results: 60 knees in 59 adolescents underwent the combined TPH/ITB ACLR, with 49 knees meeting inclusion criteria with a mean follow up = 23 months (r = 12-48 m). Only 1/49 knees (2%) sustained ACL re-injury. Mean age was 12.9y (11-16y) with 29 males (mean bone-age = 14.1) and 19 females (mean bone-age =13.3). There was a high level return to pre-operative sport. No families reported cosmetic, functional alignment or length concerns, and no clinical deformity was diagnosed. Outcome measures at final follow up indicated a high functional level with a mean Pedi-IKDC = 90.39 and mean Pedi-Fabs = 22.66. To critically assess growth, a cohort of 22 knees (mean age = 12.8y) with > 18 months of growth remaining at surgery were evaluated at maturity. No difference was seen in mean operative and non-operative leg growth (54.1 mm and 53.0 mm). One patient, 1/22 (4.5%), had a final LLD > 10 mm (12 mm), and peri-operative alignment difference [0-GII (central compartment) valgus]. Growth and alignment were not significantly associated with age, bone age, height, weight, demonstrated growth, or pre-operative alignment. Conclusion: Combined TPH/ITB ACLR in adolescent patients resulted in return to high activity levels (Pedi-Fabs = 22.66), and a low (2%) re-injury rate at an average of 23 months. A novel pediatric ACLR employing combined trans-physeal hamstring and extra-osseous iliotibial band grafts merits further study as a technique for reducing re-injury in high-risk, growing adolescents by maximizing articular graft size while adding anterior-lateral rotational knee control. [Figure: see text]
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Erős, Adrienn, Dóra Dohos, Gábor Veres, András Tárnok, Áron Vincze, Alexandra Tészás, Noémi Zádori, Noémi Gede, Péter Hegyi e Patrícia Sarlós. "Effect of joint transition visits on quality of life in adolescents with inflammatory bowel diseases: a protocol for a prospective, randomised, multicentre, controlled trial (TRANS-IBD)". BMJ Open 10, n. 10 (ottobre 2020): e038410. http://dx.doi.org/10.1136/bmjopen-2020-038410.
Testo completoAbstract (sommario):
IntroductionInflammatory bowel diseases (IBD) are among the most common chronic illnesses diagnosed in childhood. Transition from paediatric to adult care is a crucial phase. The implementation of joint visits during the transition period in IBD is widely recommended, however, strong evidence supporting their benefit is still missing. In this trial, we aim to prove the superiority of joint visits compared with usual care in improving transition outcomes of adolescents with IBD.Methods and analysisThis is a randomised controlled two-arm multicentre trial. A minimum of 160 adolescents with IBD aged between 16.75 and 17 years will be recruited from Hungarian tertiary IBD centres. After randomisation, eligible subjects in the intervention arm attend a total of four joint visits with adult and paediatric gastroenterologist between the ages of 17 and 18. In the control arm, adolescents meet only the paediatric gastroenterologist, but there is a balanced consultation between the two gastroenterologist regarding the patient’s treatment plan. Patients in both groups receive the same training and education, the only determinative difference between the two arms is the presence of the adult gastroenterologist at the joint visits. Data will be collected at inclusion, at transfer and 12 months post-transfer. Primary outcome is the change in health-related quality of life measured with the IMPACT-III questionnaire at 1 year after transfer. Secondary outcomes include the number of patients not lost to follow-up, healthcare utilisation, disease activity, medication adherence, self-efficacy, transition readiness and patient’s satisfaction. To compare the results of the two patient groups, two-sample T-test and Mann-Whitney test will be applied.Ethics and disseminationThe Scientific and Research Ethics Committee of the Hungarian Medical Research Council approved this study (50457-2/2019/EKU). Findings will be disseminated at conferences and in medical journals.Trial registration numberNCT04290156.
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Xu, Anthony A., Luke K. Kennedy, Kristi Hoffman, Donna L. White, Fasiha Kanwal, Hashem B. El-Serag, Joseph F. Petrosino e Li Jiao. "Dietary Fatty Acid Intake and the Colonic Gut Microbiota in Humans". Nutrients 14, n. 13 (29 giugno 2022): 2722. http://dx.doi.org/10.3390/nu14132722.
Testo completoAbstract (sommario):
A high-fat diet has been associated with systemic diseases in humans and alterations in gut microbiota in animal studies. However, the influence of dietary fatty acid intake on gut microbiota in humans has not been well studied. In this cross-sectional study, we examined the association between intake of total fatty acids (TFAs), saturated fatty acids (SFAs), trans fatty acids (TrFAs), monounsaturated fatty acids (MUFAs), polyunsaturated fatty acids (PUFAs), n3-FAs, and n6-FAs, and the community composition and structure of the adherent colonic gut microbiota. We obtained 97 colonic biopsies from 34 participants with endoscopically normal colons. Microbial DNA was used to sequence the 16S rRNA V4 region. The DADA2 and SILVA database were used for amplicon sequence variant assignment. Dietary data were collected using the Block food frequency questionnaire. The biodiversity and the relative abundance of the bacterial taxa by higher vs. lower fat intake were compared using the Mann–Whitney test followed by multivariable negative binomial regression model. False discovery rate–adjusted p-values (q value) < 0.05 indicated statistical significance. The beta diversity of gut bacteria differed significantly by intake of all types of fatty acids. The relative abundance of Sutterella was significantly higher with higher intake of TFAs, MUFAs, PUFAs, and n6-FAs. The relative abundance of Tyzzerella and Fusobacterium was significantly higher with higher intake of SFAs. Tyzzerella was also higher with higher intake of TrFA. These observations were confirmed by multivariate analyses. Dietary fat intake was associated with bacterial composition and structure. Sutterella, Fusobacterium, and Tyzzerella were associated with fatty acid intake.
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Cruz-Ordoñez, Sandra Xochiquetzal, María Fernanda Chein-Vázquez, Omar Dimas Victorio-Vargas, César Cervantes-Palma, Luis Alberto Lemus-Hernández, Mario Alberto Toledo-Díaz, Jesús Javier Torres-Gómez et al. "Comparación de los resultados funcionales post operatorios en enucleación prostática con láser holmio, fotovaporización prostática con láser verde y resección transuretral de próstata en el tratamiento de la hiperplasia prostática obstructiva". Revista Mexicana de Urología 82, n. 3 (30 giugno 2022): 1–13. http://dx.doi.org/10.48193/revistamexicanadeurologa.v82i3.743.
Testo completoAbstract (sommario):
Objetivo: Comparar los resultados funcionales en pacientes operados de resección transuretral de próstata (RTUP), fotovaporización prostática con láser GreenLight ® (FTV) y enucleación prostática con láser Holmio (HOLEP), en el tratamiento de la obstrucción prostática benigna en el Hospital Central Militar. Material y métodos: Se aplicó cuestionario de índice internacional de sintomatología prostática (IPSS), Uroflujometría (Qmax), ultrasonografía vesical pre y postmiccional (PVR) a los pacientes llevados a RTUP, FTV y HOLEP de manera pre y post operatoria de enero del 2018 a marzo del 2019. Se analizaron las pruebas descriptivas y de normalidad de Shapiro-Wilks para las variables cuantitativas; los datos de comportamiento paramétrico se analizaron con pruebas de ANOVA, y los no paramétricos se analizaron con pruebas de U de Mann-Whitney y Kruskal-Wallis. Se utilizó paquete estadístico GraphPad PRISM v7.0. Resultados: Se evaluaron 46 pacientes de RTUP, 62 de HOLEP y 17 de FTV, eliminando aquellos que no lograron seguimiento postoperatorio completo; describiendo las características demográficas, las comorbilidades más frecuentes y los parámetros evaluados de manera preoperatoria. En el seguimiento, HOLEP fue ligeramente mejor que FTV o RTUP; sin encontrar significancia estadística entre los grupos, observando mejoría marcada de los valores de referencia de IPSS, Qmax y PVR pre y post operatorios en todas las poblaciones. Conclusiones: No se comprobó superioridad de alguna de las técnicas en cuanto a resultados funcionales postoperatorios a corto plazo, por lo que se propone realizar estudios a largo plazo, considerando agregar parámetros trans y postoperatorios a fin de demostrar superioridad de estas técnicas.
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Morais, Ana Carolina Bail, Lize Stangarlin-Fiori, Renata Labronici Bertin e Caroline Opolski Medeiros. "Consumers’ knowledge and use of nutritional information on food labels". DEMETRA: Alimentação, Nutrição & Saúde 15 (30 aprile 2020): e45847. http://dx.doi.org/10.12957/demetra.2020.45847.
Testo completoAbstract (sommario):
A rotulagem de alimentos é importante para a comunicação entre produtores e consumidores. No entanto, para ajudar os consumidores a ter maior autonomia em suas escolhas alimentares, é importante interpretar corretamente a rotulagem dos alimentos. Assim, esta pesquisa avaliou o conhecimento e o uso das informações nutricionais apresentadas nos rótulos dos alimentos. Pesquisa quantitativa, exploratória e transversal, realizada em 2018 em uma universidade pública no Brasil, com 415 consumidores com 18 anos ou mais. Para avaliar o conhecimento, aplicou-se questionário estruturado com pontuação de 0 a 24. Os dados foram analisados por meio de análise descritiva, correlação de Spearman e teste de Kruskal-Wallis e Mann Whitney. Participaram indivíduos com idade de 21,02 ± 2,89 anos, dos quais 58,31% eram do sexo feminino. Muitos consumidores liam frequentemente os rótulos dos alimentos (56,39%). A pontuação média de conhecimento foi de 14,99 ± 4,12. A média do escore de conhecimento foi afetada pela idade (p = 0,039) e renda (p = 0,020). Os participantes que utilizaram alegações nutricionais como critério de compra (p = 0,004) obtiveram maiores pontuações. Os maiores problemas na interpretação dos rótulos nutricionais estavam relacionados às reivindicações obrigatórias de nutrientes e aos termos "isento de gordura trans (0%)", "alimento funcional", "dieta" e "light". Considerando que a regulamentação dos rótulos de alimentos está em processo de revisão no Brasil, torna-se importante pesquisar seu uso e conhecimento por consumidores adultos jovens. Isso contribuirá para a discussão da revisão da legislação, além de ajudar os profissionais a orientarem os consumidores na interpretação dos rótulos.
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Faramarz-Gaznagh, Sanaz, Yousef Rasmi, Mohammad-Hasan Khadem-Ansari, Mir-Hossein Seyed-Mohammadzad, Morteza Bagheri, Mohadeseh Nemati, Alireza Shirpoor e Ehsan Saboori. "Transcriptional Activity of Gene Encoding Subunits R1 and R2 of Interferon Gamma Receptor in Peripheral Blood Mononuclear Cells in Patients with Slow Coronary Flow". Journal of Medical Biochemistry 35, n. 2 (1 aprile 2016): 144–49. http://dx.doi.org/10.1515/jomb-2015-0019.
Testo completoAbstract (sommario):
Summary Background: Slow coronary flow (SCF) is a coronary artery disorder characterized with delayed opacification of epicardial coronary arteries without obstructive coronary disease. The pathophysiological mechanisms of SCF remain un clear. One of the possible mechanisms that may participate in the pathology of SCF is endothelial dysfunction related to the inflammatory process. Interferon gamma (IFN-γ) is an inflammatory cytokine that acts through its specific receptor composed of two subunits, IFN-γR1 and IFN-γR2. Trans criptional activity of the gene encoding these subunits influences IFN-γ activity. This study aimed to investigate the gene expression of IFN-γ receptor subunits in peripheral blood mononuclear cells (PBMC) from patients with SCF. Methods: The study was performed with 30 patients (22 male/8 female) aged 35–76 (52.8±11.7 years) with SCF and 15 sex-(11 male/4 female), Body Max Index (BMI)-and age-matched (54.73±9.42 years) healthy subjects. Total mRNA was extracted from PBMC and was determined by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). The relative expression values (2−ΔΔCt) between control and case groups were determined and the Mann-Whitney U test was used for statistical analysis. Results: There was a significant increase in the gene expression of IFN-γR1 in PBMC from SCF patients vs. controls (P< 0.0001); but the differences in IFN-γR2 gene expression were statistically insignificant between patient and control groups (P= 0.853). Conclusions: It can be concluded that IFN-γR1 gene expression may influence the function of microvasculature and thereby contribute to the pathophysiology of SCF.
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Ho, Lok-Man, Sai-Kit Lam, Jiang Zhang, Chi-Leung Chiang, Albert Chi-Yan Chan e Jing Cai. "Association of Multi-Phasic MR-Based Radiomic and Dosimetric Features with Treatment Response in Unresectable Hepatocellular Carcinoma Patients following Novel Sequential TACE-SBRT-Immunotherapy". Cancers 15, n. 4 (9 febbraio 2023): 1105. http://dx.doi.org/10.3390/cancers15041105.
Testo completoAbstract (sommario):
This study aims to investigate the association of pre-treatment multi-phasic MR-based radiomics and dosimetric features with treatment response to a novel sequential trans-arterial chemoembolization (TACE) plus stereotactic body radiotherapy (SBRT) plus immunotherapy regimen in unresectable Hepatocellular Carcinoma (HCC) sub-population. Twenty-six patients with unresectable HCC were retrospectively analyzed. Radiomic features were extracted from 42 lesions on arterial phase (AP) and portal-venous phase (PVP) MR images. Delta-phase (DeltaP) radiomic features were calculated as AP-to-PVP ratio. Dosimetric data of the tumor was extracted from dose-volume-histograms. A two-sided independent Mann–Whitney U test was used to assess the clinical association of each feature, and the classification performance of each significant independent feature was assessed using logistic regression. For the 3-month timepoint, four DeltaP-derived radiomics that characterize the temporal change in intratumoral randomness and uniformity were the only contributors to the treatment response association (p-value = 0.038–0.063, AUC = 0.690–0.766). For the 6-month timepoint, DeltaP-derived radiomic features (n = 4) maintained strong clinical associations with the treatment response (p-value = 0.047–0.070, AUC = 0.699–0.788), additional AP-derived radiomic features (n = 4) that reflect baseline tumoral arterial-enhanced signal pattern and tumor morphology (n = 1) that denotes initial tumor burden were shown to have strong associations with treatment response (p-value = 0.028–0.074, AUC = 0.719–0.773). This pilot study successfully demonstrated associations of pre-treatment multi-phasic MR-based radiomics with tumor response to the novel treatment regimen.
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Brooks, Peter Newman. "Martin Luther. The man and his work. By Walther von Loewenich. (Trans, by Lawrence W. Denef of Martin Luther: Der Mann und das Werk, 1982.) Pp. 446. Minneapolis, Minn.: Augsburg Publishing House, 1986. 0 8066 2019 6". Journal of Ecclesiastical History 40, n. 2 (aprile 1989): 309. http://dx.doi.org/10.1017/s0022046900043244.
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Guérin-Boutaud, Jean-Louis. "L'ombre de la main providentielle de Dieu dans les Sermons paroissiaux de John Henry Newman". Transversalités 128, n. 4 (2013): 91. http://dx.doi.org/10.3917/trans.128.0091.
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Giorgetti, Ana Paula Oliveira, Rafaela de Matos, Renato Corrêa Viana Casarin, Suzana Prese Pimentel, Fabiano Ribeiro Cirano e Fernanda Vieira Ribeiro. "Preemptive and Postoperative Medication Protocols for Root Coverage Combined with Connective Tissue Graft". Brazilian Dental Journal 29, n. 1 (febbraio 2018): 23–29. http://dx.doi.org/10.1590/0103-6440201801452.
Testo completoAbstract (sommario):
Abstract This trial evaluated the preemptive and postoperative effect of dexamethasone and ibuprofen on prevention of pain/discomfort, edema and interference in daily life in patients undergoing root coverage combined with subepithelial connective tissue graft (CAF + CTG). Twenty patients were randomly assigned as follows: NSAID Group: 400mg Ibuprofen 60 min preemptive + 400mg Ibuprofen postoperative; or SAID Group: 4mg Dexamethasone 60 min preemptive + 4mg Dexamethasone postoperative. The postoperative medication was administered 8 and 16 h post-surgery. Each patient received questionnaires based on a numeric scale (101-point numeric scale rate [NRS-101]) and multiple choice questions (four-point verbal rating scale [VRS-4]) about trans-operative pain/discomfort, hourly for 8 h after surgery and once a day for three days. A Visual Analogue Scale (VAS) for edema and interference in daily life during the 1st, 2nd, 3rd and 7th day was also answered. The degree of anxiety was rated statistically by the Chi-square test. The Mann-Whitney and Friedman tests were used for the other questionnaires. The surgery time and number of analgesic pills consumed were compared using Student’s t-test. Patients who used dexamethasone presented a trend toward less pain when compared to individuals who ingested ibuprofen, with a significant difference observed 3 h after the procedure (p<0.05). The use of dexamethasone also promoted less edema until the 2nd day and lower interference in daily life on the third day when compared with ibuprofen (p<0.05). We concluded that the use of dexamethasone as a preemptive and postoperative medication was more suitable as a drug therapeutic protocol for CAF + CTG.
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Lau, David P., Gwyneth Lee, Seng Mun Wong, Yiong Huak Chan, Nam Guan Tan, Linda Rammage e Murray Morrison. "S181 – Injection Laryngoplasty with Hyaluronic Acid". Otolaryngology–Head and Neck Surgery 139, n. 2_suppl (agosto 2008): P136—P137. http://dx.doi.org/10.1016/j.otohns.2008.05.355.
Testo completoAbstract (sommario):
Objectives To determine if particle size affects durability of medialisation in patients undergoing injection laryngoplasty (IL) with hyaluronic acid (HA) for unilateral vocal cord paralysis (UVCP). Hypothesis: Larger particle-size HA persists longer after injection to produce a more durable vocal result. Methods Study Design: Prospective randomized controlled single-blind trial. Years conducted: 2005–2007. Condition studied: UVCP. Subjects: Patients over the age of 18 requiring medialisation for UVCP. Setting: Outpatient clinic setting. Intervention: Patients underwent transcutaneous IL with Restylane (small particle-size HA) or Perlane (large particle-size HA). Outcome measurement: The Voice Handicap Index (VHI) at 6 months post-injection was the primary outcome measure. Secondary outcomes included videostroboscopic findings, and objective acoustic and aerodynamic measures. Statistical methods: Differences between groups were compared using the Mann Whitney U test and adjusted for age & gender using ANCOVA. Results 17 patients (8 Restylane, 9 Perlane) were available for follow-up at 6 months. Normalised VHI scores at 6 months after IL were significantly lower in the Perlane group compared to the Restylane group when not adjusted for age and sex (p=0.027). After adjustment the difference was not significant (p=0.053) but the Perlane group trended towards lower normalised VHI scores. Conclusions The findings support the hypothesis that the larger particle size of Perlane makes this material more durable than Restylane for IL. This material may be considered for temporary medialisation in patients with UVCP in whom medium-term improvement of at least 6 months is desirable. The trans-cutaneous route can be used safely in the office setting in non-anti-coagulated patients.
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Article, Editorial. "TRANS-SIBERIAN MAIN LINE CELEBRATES CENTENARY". World of Transport and Transportation 14, n. 5 (28 ottobre 2016): 197. http://dx.doi.org/10.30932/1992-3252-2016-14-5-34.
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For the English full text of the article please see the attached PDF-File (English version follows Russian version).A bridge in Khabarovsk across the Amur River was opened to regular traffic on 5 October 1916, completing the last stretch of the Trans-Siberian Main Line. Based on releases of press service of JSC Russian Railways
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Turner, T., D. C. Rolland, N. Aldai e M. E. R. Dugan. "Short Communication: Rapid separation of cis9, trans11- and trans7,cis9-18:2 (CLA) isomers from ruminant tissue using a 30 m SLB-IL111 ionic column". Canadian Journal of Animal Science 91, n. 4 (dicembre 2011): 711–13. http://dx.doi.org/10.4141/cjas2011-071.
Testo completoAbstract (sommario):
Turner, T., Rolland, D. C., Aldai, N. and Dugan, M. E. R. 2011. Short Communication: Rapid separation of cis 9, trans 11- and trans 7,c is 9-18:2 (CLA) isomers from ruminant tissue using a 30 m SLB-IL111 ionic column. Can. J. Anim. Sci. 91: 711–713. Rumenic acid (cis9,trans11-18:2) is the main natural isomer of conjugated linoleic acid (CLA). Rumenic acid has many purported health benefits, but effects of most other CLA isomers are unknown. Typically trans7,cis9-18:2 is the second most abundant CLA isomer, but it co-elutes with rumenic acid on conventional polar gas chromatography (GC) columns, requiring complimentary analysis with silver-ion high performance liquid chromatography (Ag+-HPLC). Herein we report a rapid method for analyzing rumenic acid and trans7,cis9-18:2 using a 30 m ionic-liquid GC column. Optimal resolution of the two CLA isomers was at 145°C and analysis of backfat from barley-fed cattle compared well with GC/Ag+-HPLC (y=0.978x – 0.031, r=0.985, P<0.001).
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Boyer, Guillaume. "Les liens de plume. Envois et dédicaces à la main dans la bibliothèque de Paul Bourget". Transversalités 165, n. 2 (3 aprile 2023): 67–76. http://dx.doi.org/10.3917/trans.165.0067.
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Samama, Evelyne C. "A NEW TRANSLATION OF THUCYDIDES - (J.E.) Mann (ed., trans.) Hippocrates, On the Art of Medicine. (Studies in Ancient Medicine 39.) Pp. xii + 279. Leiden and Boston: Brill, 2012. Cased, €110, US$151. ISBN: 978-90-04-22413-1." Classical Review 64, n. 2 (23 giugno 2014): 376–77. http://dx.doi.org/10.1017/s0009840x1400122x.
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Gupta, Satish C., Nathaniel W. Baeumler, Andrew C. Kessler, Melinda K. Brown, William M. Schuh e Kari A. Wolf. "Increased Precipitation as the Main Driver of Increased Streamflow in Tile-Drained Watersheds of the Upper Midwestern U.S." Transactions of the ASABE 61, n. 1 (2018): 207–22. http://dx.doi.org/10.13031/trans.12279.
Testo completoAbstract (sommario):
Abstract. Recent increased streamflow (Q) and its associated impacts on water quality have frequently been linked to land use and land cover (LULC) changes such as increased tile drainage, cultivation of prairies, and adoption of soybean () in modern-day cropping systems. However, many previous studies have assumed minimal to no change in precipitation during their study period. A recent analysis of streamflow records from 29 HUC 8 (Hydrologic Unit Code 008) watersheds in Iowa and Minnesota showed that increased precipitation instead of LULC change was the main driver of increased streamflow. The analysis was done through hierarchical regression of annual streamflow as a function of annual precipitation for the periods prior to 1975 (pre-change period) and after 1976 (post-change period). A statistical shift in annual relationship from the pre- to post-change period was assumed to be an indication of LULC changes, whereas a lack of statistical shift suggested no change in the relationship and higher flows were mainly driven by increased precipitation. In this article, we further show that annual streamflow and annual baseflow were influenced not only by the current year’s precipitation but also by precipitation in the preceding one to two years, and this effect was manifested through increased or decreased stored soil water. The present analysis was done using backward stepwise hierarchical regression with the natural log of annual streamflow as the predictor variable and three to five years of precipitation, the area under soybean production, a group variable simulating pre- and post-change periods, and its interaction terms with precipitation and soybean area as the explanatory variables. This analysis also showed that precipitation was the main driver of annual streamflow or baseflow; however, for some rivers, the area under soybean production and group differences were also significant variables, although at a much smaller confidence level. Annual streamflow testing was done for the Blue Earth River, Redwood River, Cottonwood River, and Whetstone River watersheds in Minnesota and the Maquoketa River and Raccoon River watersheds in Iowa. Annual baseflow testing was done only on the Redwood River and Raccoon River watersheds. Using similar backward stepwise regressions, the analysis showed that changes in Ln(monthly streamflow) were linked to stored soil water through the preceding months’ and years’ precipitation. On a daily scale, comparison of slopes of the hydrograph’s rising limb for two large precipitation events in 1957 (pre-change period) and 1993 (post-change period) showed less watershed connectivity due to LULC changes such as drainage, a finding that is contrary to what has been suggested in the literature. A similar comparison of the falling limb slopes for a given streamflow condition showed similar slope values in pre-change (1947) and post-change (1991) periods, thus suggesting no changes in storage capacity of the watershed as a result of LULC changes. Further comparisons of high-level streamflows (Q > 100 m3 s-1) as a function of average daily storm precipitation showed no effect of drainage between the pre- and post-change periods. A statistical analysis of the relationship between the falling limb slopes as a function of streamflow for low (dQ/dt < -5 m3 s-1 d-1) and medium (dQ/dt varying from -2 to -5 m3 s-1 d-1) slopes also showed no discernable change in the retentive capacity of the Redwood River watershed between the pre- and post-change periods. The above evaluations at three temporal scales further supported our previous conclusion that increased precipitation in recent years is the main driver of the increased streamflow in tile-drained watersheds of the upper Midwestern U.S., and the impacts of LULC change on streamflow characteristics were minimal. We conclude that any comparison of daily, monthly, or annual streamflow and baseflow to evaluate LULC change impacts must be done at comparable stored soil water conditions or with accounting of precipitation from previous days, months, and years. Keywords: Baseflow, Hydrograph, Land use land cover, Precipitation, Streamflow, Tile drainage.