Letteratura scientifica selezionata sul tema "Teprin associati"

The life, scientific and pedagogical activities of Vasil Pavlovich Tepin, one of the organizer of the Belarusian State University, are considered in this article. As a dean of the faculty of pre-university education and later – associate professor at the pedagogical faculty – he published number of scientific and methodical works, made a significant contribution not only to the formation of university education, but also in the development of the Belarusian high school. V. P. Tepin was one of the victims of Stalin repressions of 1930s. After the beginning of the Great Patriotic War, he stayed in Minsk and worked in the School Department of local administration. During the German occupation, he wrote his last work, «History of the Belarusian State University», in which he outlined his assessment of the events that preceded the creation of the university, the history of the first years of the BSU activities, his attitude to a number of teachers and political leaders of Belarus during the interwar period. The memoirs of V. P. Tepin, taken in comparison with the memoirs of other BSU staff and students of those two decades, help to reconstruct in more details the little-studied pages of the history of the first Belarusian university.

Grain size parameters and clay mineralogical analyses were used to characterize and compare Okareka Ash and post-Okareka tephric loess sampled at eight sites on a transect in Rotorua district, North Island, New Zealand. Grain size distribution analyses show consistently lower mean size and better sorting of the tephric loess compared with the Okareka Ash. The mean grain size of the loess is strongly influenced by the mean grain size of the tephra. Trends in the distribution of biotite and halloysite support the grain size distribution analyses. Taken with field observations, the analytical evidence allows differentiation between Okareka Ash and overlying associated tephric loess.

The micro, small and medium-sized enterprises (MSMEs) are exposed to a several situations external to their main activities, for that reason MSMEs are forced to develop new strategies that allow them to continue in the business, even in the adversity. In addition, the business association has become a relevant issue in the public and private agenda, because this is a way for the MSMEs to increase their competitiveness and achieve specific objectives, which if done individually it would be a slower process and with less impact for the local economic development. With this background, the objective of this research is to determinate if in Tepic City, Nayarit, the inter-business associations serve or can serve as a strategy for boost the economic development of the area. A semi-structured interview was conducted with two established inter-business associations: Association of Automobile Distributors of Nayarit, and Tepic Hotels and Motels Association. The main result is that the currently established business associations have as main motivation to have power of decision in the sector, moreover to have representation in front of government policies, without forgetting the join structure which has allowed them to improve their quality and training.

Background : Febrile seizures are disorders that arise due to an abnormal increase in body temperature (> 38 0 C). Febrile seizures are often associated with epilepsy and the risk of mental retardation in children. Method : The design of this research is a case study using the subject of 2 pediatric patients who experienced febrile seizures with hyperthermia nursing problems on the first day, nursing care was carried out 3 consecutive days by providing warm compresses or tepid sponge interventions. Results : The results showed the problem of hyperthermia with warm compresses or a tepid sponge, the problem was resolved in reducing the increase in body temperature. Analysis : To carry out nursing care for clients who experience febrile seizures with priority problems of hyperthermia. Conclution : Warm compresses or tepid sponges can be used in hospitals as additional therapy to lower body temperature.

Vochysia tepuiandina is here described and illustrated. It occurs in southern Ecuador and northern Peru, and is associated with the disjunct “Andean Tepuis” forests found within the Andean piedmont and of the Amazonian forests. This species is placed in the Vochysia section Ciliantha subsection Ferrugineae. It is compared with the similar species V. angustifolia and V. sprucei.

Despite recent advances in mass spectrometry, proteomic characterization of transport vesicles remains challenging. Here, we describe a multivariate proteomics approach to analyzing clathrin-coated vesicles (CCVs) from HeLa cells. siRNA knockdown of coat components and different fractionation protocols were used to obtain modified coated vesicle-enriched fractions, which were compared by stable isotope labeling of amino acids in cell culture (SILAC)-based quantitative mass spectrometry. 10 datasets were combined through principal component analysis into a “profiling” cluster analysis. Overall, 136 CCV-associated proteins were predicted, including 36 new proteins. The method identified >93% of established CCV coat proteins and assigned >91% correctly to intracellular or endocytic CCVs. Furthermore, the profiling analysis extends to less well characterized types of coated vesicles, and we identify and characterize the first AP-4 accessory protein, which we have named tepsin. Finally, our data explain how sequestration of TACC3 in cytosolic clathrin cages causes the severe mitotic defects observed in auxilin-depleted cells. The profiling approach can be adapted to address related cell and systems biological questions.

Herbivores and plants have been engaged in a tight co-evolutionary arms race, and saliva played important roles in this process. Some herbivore-derived small molecules or proteins called herbivore-associated molecular patterns (HAMPs) can be recognized by plants and thus trigger plant immune responses. Another type of salivary proteins, called effectors, utilize various strategies to suppress plant defense responses to establish successful feeding. The tomato red spider mite Tetranychus evansi is a worldwide pest of Solanaceous crops and causes enormous economic damage in many regions of the world. During the feeding process, T. evansi secretes saliva into plant cells through cheliceral stylets. Secreted saliva plays crucial roles in modulating plant-mite interaction, such as effectors Te28 and Te84 (Villarroel et al., 2016). We previously identified 136 salivary proteins from T. evansi by transcriptome and LC-MS/MS analyses (Huang et al., 2018). However, the role of these salivary proteins in mite-plant interaction was unknown. Here, we identified a salivary protein involved in the mite-plant interaction (Cui et al., 2022). This protein encodes a protein disulfide isomerase (TePDI) and acts as a HAMP that triggers plant defenses by inducing ROS burst, callose deposition and plant defense-related genes in Nicotiana benthamiana. TePDI can be recognized by multiple Solanaceae plants such as tomato, pepper, and eggplant. TePDI-mediated cell death in N. benthamiana is dependent on the plant signaling molecules SGT1 (suppressor of the G2 allele of skp1) and HSP90 (heat shock protein 90). To better feed on plants, T. evansi inhibited TePDI-triggered cell death and plant defense responses by secreting effectors Te28 and Te84. Further analysis revealed that PDI from phylogenetically distinct herbivorous and non-herbivorous arthropods all triggered cell death and immune response in N. benthamiana. Moreover, silencing PDI gene in spider mites and whiteflies resulted in the reduced survival rate of both pests. Altogether, our study revealed that PDI is a double-edged sword. On the one hand, it is functionally conserved in herbivores and required for their survival; on the other hand, it is recognized by Solanaceae plants and enhances plant resistance against herbivores. Our findings indicate that plants utilize evolutionarily conserved HAMPs to activate plant defense and resist pest damage, providing a potential strategy for pest management.

ABSTRACTThe Tahunaatara sinter, Taupo Volcanic Zone, New Zealand, is a ∼17–20-kyr-old hot-spring deposit of opal-A mineralogy. It is interbedded with fluvial, lacustrine and volcaniclastic sediments, some silicified by infusing thermal waters. The exposed sinter (∼4 m thick, 90 m long) was truncated at its southern margin by a landslide, which deposited a conglomerate (up to 2 m thick, 56 m long) of sinter blocks and associated strata nearby. Kaolinite-rich cobbles at the base of the conglomerate indicate a change in the thermal regime and its probable trigger: acid steamcondensate produced alteration. Clasts in the landslide are oriented SW, the same direction as flattened plant reeds entombed in sinter, and as intercalated fluvial beds. Thus, thermal waters, stream flow and the landslide all likely followed the same palaeo-valley, which is similar in terrain and stratigraphy to the Devonian Rhynie hydrothermal system. The plant-rich, layered, in situ sinter contains fossilised microbes and rare stromatolites, and was deposited on mid- to distal slopes adjacent to marshes. Ash falls, fluvial activity and ponding occurred during and after the thermal activity. Unsilicified tephric Ohakea loess (∼26–17 kyr BP) and Taupo Tephra (1·86 kyr BP) blanket both sinter and landslide. Today, the deposits form resistant remnants in a topographically inverted landscape.

Unitarianism and Presbyterian Dissent had a complex relationship in the nineteenth century. Neither English Unitarians nor their Presbyterian cousins grew much if at all in the nineteenth century, but elsewhere in the United Kingdom the picture was different. While Unitarians failed to prosper, Presbyterian Dissenting numbers held up in Wales and Ireland and increased in Scotland thanks to the Disruption of the Church of Scotland. Unitarians were never sure whether they would benefit from demarcating themselves from Presbyterians as a denomination. Though they formed the British and Foreign Unitarian Association, its critics preferred to style themselves ‘English Presbyterians’ and Presbyterian identities could be just as confused. In later nineteenth-century Scotland and Ireland, splinter Presbyterian churches eventually came together; in England, it took time before Presbyterians disentangled themselves from Scots to call themselves the Presbyterian Church of England. While Unitarians were tepid about foreign missions, preferring to seek allies in other confessions and religions rather than converts, Presbyterians eagerly spread their church structures in India and China and also felt called to convert Jews. Missions offered Presbyterian women a route to ministry which might otherwise have been denied them. Unitarians liked to think that what was distinctive in their theology was championship of a purified Bible, even though other Christians attacked them as a heterodox bunch of sceptics. Yet their openness to the German higher criticism of the New Testament caused them problems. Some Unitarians exposed to it, such as James Martineau, drifted into reverent scepticism about the historical Jesus, but they were checkmated by inveterate conservatives such as Robert Spears. Presbyterians saw their adherence to the Westminster Confession as a preservative against such disputes, yet the Confession was increasingly interpreted in ways that left latitude for higher criticism. Unitarians started the nineteenth century as radical subversives of a Trinitarian and Tory establishment and were also political leaders of Dissent. They forfeited that leadership over time, but also developed a sophisticated, interventionist attitude to the state, with leaders such as H.W. Crosskey and Joseph Chamberlain championing municipal socialism, while William Shaen and others were staunch defenders of women’s rights and advocates of female emancipation. Their covenanting roots meant that many Presbyterians were at best ‘quasi-Dissenters’, who were slower to embrace religious voluntaryism than many other evangelical Dissenters. Both Unitarians and Presbyterians anguished about how to reconcile industrial, urban capital with the gospel. Wealthy Unitarians from William Roscoe to Henry Tate invested heavily in art galleries and mechanics institutes for the people but were disappointed by the results. By the later nineteenth century they turned to more direct forms of social reform, such as domestic missions and temperance. Scottish Presbyterians also realized the importance of remoulding the urban fabric, with James Begg urging the need to tackle poor housing. Yet neither these initiatives nor the countervailing embrace of revivalism banished fears that Presbyterians were losing their grip on urban Britain. Only in Ireland, where Home Rule partially united the Protestant community in fears for its survival, did divisions of space and class seem a less pressing concern.

Abstract Juvenile delinquents with externalizing disorders are a challenging, yet rewarding, population to treat. The externalizing disorders—namely, attention-deficit/ hyperactivity disorder (ADHD), conduct disorder (CD), and oppositional defiant disorder (ODD)—are some of the most common encountered by practitioners working with juvenile delinquents (Kazdin, 2002; Kronenberger & Meyer, 2001). In studies of community and clinic samples, a large percentage of youths with CD or ADHD (e.g., 45% to 70%) also met criteria for the other disorder (Fergusson, Horwood, & Lloyd, 1991), and comorbidity between CD and ODD, anxiety disorders, and depression is common as well (Kazdin, 2002). In a recent epidemiological study that examined psychiatric disorders in juvenile delinquents (Teplin, Abram, McClelland, Dulcan, & Mericle, 2002), the most common disorders were substance use disorders and disruptive behavior disorders (ODD and CD), with more than 40% of males and females meeting criteria for a disruptive behavior disorder. Accordingly, this chapter presents a case exemplar of treating a juvenile delinquent dually diagnosed with conduct disorder and alcohol abuse. First, it is important to highlight the difference between juvenile delinquency and CD. Many readers may be aware of the behaviors associated with a diagnosis of CD, such as aggressive behavior toward others, using a weapon, fire setting, cruelty to animals or persons, vandalism, lying, truancy, running away, and theft (American Psychiatric Association [APA], 2000). The DSM-IV-TR allows for coding a client with one of two subtypes of CD: childhood-onset type (at least one criterion characteristic occurs prior to age 10) and adolescent-onset type (absence of any criteria prior to age 10). While an adolescent may be considered a “juvenile delinquent” after only one delinquent act, to warrant a diagnosis of CD, that same adolescent must be engaged over an extended period (at least 6 months) in a pattern of behavior that consistently violates the rights of others and societal norms. It is critical, therefore, that practitioners take painstaking care in their diagnostic assessments of conduct disorder, as both false positives and false negatives carry potentially serious consequences for both the offender and society (Springer, McNeece, & Arnold, 2003).

Off the coasts of northern Perú and southern Ecuador, warm equatorial waters meet the cold Humboldt Current. Variations in sea temperatures and associated fauna have been known to fishing folk since colonial times. They noticed that toward the end of every year tepid waters appeared between the Gulf of Guayaquil (Ecuador) and Point Pariñas (Perú) and persisted until late February, causing tropical species to be added to the fish they commonly caught. Coupled with the arrival of warm waters was a surge in air humidity and an increase in summer showers. Since this environmental phenomenon occurred around Christmas, the local fishermen called it El Niño, or Child Jesus. Early scientific observations on the nature and extent of these phenomena revealed that they were not regionally restricted to coastal Perú and Ecuador, but extended over the whole tropical Pacific, involving pressure fields and wind flows across the basin. Thus, when referring to this coupled ocean-atmospheric system, both variations of sea temperature across the tropical Pacific and changes of the atmosphere in contact with the ocean must be considered (Neelin et al., 1998). Normally, the tropical Pacific Ocean, from the coast of Ecuador and Perú to longitude 120°W, is dominated by westward- flowing cold waters, which are the prolongation of the Humboldt Current. Near longitude 120°W, sea surface temperatures approach normal equatorial values of ~28°C. When the flow reaches the western Pacific, it creates a sealevel rise of nearly 40 cm, which is maintained by the wind shear of the equatorial easterlies. The thermocline, which marks the lower boundary of the sun-heated water layer, runs at a depth of 40 m between Perú and the Galápagos Islands, but on the Asian side of the Pacific it dips to 120 m, revealing a marked asymmetry in the thickness of the sunheated layer across the Pacific. During El Niño years, the westward flow of cooler waters is weak because there is less wind shear from the easterly winds, and the thermocline plunges to 80 m in the eastern equatorial Pacific.