Letteratura scientifica selezionata sul tema "Telomere Position Effect"
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Articoli di riviste sul tema "Telomere Position Effect":
Dahlén, Maria, Per Sunnerhagen e Teresa S. F. Wang. "Replication Proteins Influence the Maintenance of Telomere Length and Telomerase Protein Stability". Molecular and Cellular Biology 23, n. 9 (1 maggio 2003): 3031–42. http://dx.doi.org/10.1128/mcb.23.9.3031-3042.2003.
de Bruin, Derik, Sara M. Kantrow, Rachel A. Liberatore e Virginia A. Zakian. "Telomere Folding Is Required for the Stable Maintenance of Telomere Position Effects in Yeast". Molecular and Cellular Biology 20, n. 21 (1 novembre 2000): 7991–8000. http://dx.doi.org/10.1128/mcb.20.21.7991-8000.2000.
Park, Yangsuk, e Arthur J. Lustig. "Telomere Structure Regulates the Heritability of Repressed Subtelomeric Chromatin in Saccharomyces cerevisiae". Genetics 154, n. 2 (1 febbraio 2000): 587–98. http://dx.doi.org/10.1093/genetics/154.2.587.
Yu, Eun Young, Olga Steinberg-Neifach, Alain T. Dandjinou, Frances Kang, Ashby J. Morrison, Xuetong Shen e Neal F. Lue. "Regulation of Telomere Structure and Functions by Subunits of the INO80 Chromatin Remodeling Complex". Molecular and Cellular Biology 27, n. 16 (11 giugno 2007): 5639–49. http://dx.doi.org/10.1128/mcb.00418-07.
Runge, K. W., e V. A. Zakian. "TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae." Molecular and Cellular Biology 16, n. 6 (giugno 1996): 3094–105. http://dx.doi.org/10.1128/mcb.16.6.3094.
Mason, James M., Alexander Y. Konev, Mikhail D. Golubovsky e Harald Biessmann. "Cis- andtrans-acting Influences on Telomeric Position Effect inDrosophila melanogasterDetected With a Subterminal Transgene". Genetics 163, n. 3 (1 marzo 2003): 917–30. http://dx.doi.org/10.1093/genetics/163.3.917.
Denisenko, Oleg, e Karol Bomsztyk. "Yeast hnRNP K-Like Genes Are Involved in Regulation of the Telomeric Position Effect and Telomere Length". Molecular and Cellular Biology 22, n. 1 (1 gennaio 2002): 286–97. http://dx.doi.org/10.1128/mcb.22.1.286-297.2002.
Biessmann, Harald, Sudha Prasad, Marika F. Walter e James M. Mason. "Euchromatic and heterochromatic domains at Drosophila telomeres". Biochemistry and Cell Biology 83, n. 4 (1 agosto 2005): 477–85. http://dx.doi.org/10.1139/o05-053.
Suzuki, Y., e M. Nishizawa. "The yeast GAL11 protein is involved in regulation of the structure and the position effect of telomeres". Molecular and Cellular Biology 14, n. 6 (giugno 1994): 3791–99. http://dx.doi.org/10.1128/mcb.14.6.3791-3799.1994.
Suzuki, Y., e M. Nishizawa. "The yeast GAL11 protein is involved in regulation of the structure and the position effect of telomeres." Molecular and Cellular Biology 14, n. 6 (giugno 1994): 3791–99. http://dx.doi.org/10.1128/mcb.14.6.3791.
Tesi sul tema "Telomere Position Effect":
Rey-Millet, Martin. "Les télomères, des éléments de régulation de la transcription dans les cellules sénescentes". Electronic Thesis or Diss., Université Côte d'Azur, 2021. http://www.theses.fr/2021COAZ6022.
Telomeres, the nucleoprotein structures located at the end of eukaryotic DNA, protect chromosomal integrity. These structures undergo changes during development and aging, including length shortening and alterations in the levels of the proteins associated to them called sheltering, all this affecting genome stability as the cells age. However, telomeres also behave as transcriptional regulators acting not only on genes present at subtelomeres but also on more distantly located genes presented throughout the genome. This process is referred as Telomere Position Effect (TPE) and was initially discovered in budding yeast, but also seen in drosophila, fission yeast, plasmodium and more recently in humans. In all these organisms, genes located in the subtelomeres are repressed by an epigenetic mechanism that is dependent on telomere DNA length, telomere nucleoprotein composition and higher order chromatin organization adopted by telomeres and subtelomeres. The TPE mechanism can be described as the spreading of a heterochromatin-like structure toward the centromere most likely accompanied by the formation of large chromatin loops to further extend the transcriptional regulation emanating from a telomere to genes internally located.In this context, the goal of my thesis is to decipher whether telomeres are involved in the transcriptional remodelling occurring in human cellular senescence. For that, we performed RNA-sequencing in young versus replicative senescent lung fibroblast MRC-5 cells. Interestingly, we found an enrichment of upregulated genes in the subtelomeric regions of senescent cells suggesting a TPE alleviation. This alleviation is not homogeneous in the genome, as only some subtelomeres were enriched in upregulated genes at senescence.Finally, we tested the hypothesis that shelterin proteins may also be part of the TPE regulation. For that, we re-stored the levels of the shelterin protein TRF2 (Telomeric Repeat Binding Factor 2) whose expression is decreased as the cells approach senescence. We found that TRF2 is indeed modulating the expression of subtelomeric genes in senescent cells, and this is in part mediated by a long-range chromatin reorganization of subtelomeres as observed by conformation changes in 3D chromatin conformation by FISH.Overall, this work reveals the contribution of telomeres in the transcriptional program of senescent cells and set the basis for the relevance of TPE in the senescence/aging process
Schulz, Vera [Verfasser]. "Identifizierung von Kandidatengenen für einen "Telomer-Positions-Effekt" beim Hutchinson-Gilford-Progerie Syndrom / Vera Schulz". Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1043196927/34.
Jedrusik-Bode, Monika. "Molekulare Analyse der differentiellen Funktionen von Linkerhiston-Isoformen bei Caenorhabditis elegans". [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=964334933.
Baur, Joseph Anthony. "Telomere position effect in human cells". 2003. http://edissertations.library.swmed.edu/pdf/baurJ032003/BaurJoseph.pdf.
"Functional studies of the C-terminal domain of Sir3 (CTD) and histone H2A in telomeric position effect (TPE)". Tulane University, 2006.
acase@tulane.edu
Libri sul tema "Telomere Position Effect":
Aparicio, Oscar Martin. Telomeric position effect in S. cerevisiae: A model for the establishment of alternative transcriptional states under epigenetic control. 1993.
Capitoli di libri sul tema "Telomere Position Effect":
"Telomere Position Effect". In Encyclopedia of Genetics, Genomics, Proteomics and Informatics, 1944. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_16774.
"Telomere Position Effect". In Encyclopedia of Gerontology and Population Aging, 4974. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-22009-9_302380.
Kipling, David. "Chromatin structure and position effects". In The Telomere, 146–67. Oxford University PressOxford, 1995. http://dx.doi.org/10.1093/oso/9780199634675.003.0008.
"Telomere Position Effect and the Evolution of the Genome". In Origin and Evolution of Telomeres, 146–60. CRC Press, 2008. http://dx.doi.org/10.1201/9781498713498-14.
Pecorino, Lauren. "Regulation of gene expression". In Molecular Biology of Cancer. Oxford University Press, 2021. http://dx.doi.org/10.1093/hesc/9780198833024.003.0003.
"Telomeric Silencing (telomeric position effect)". In Encyclopedia of Genetics, Genomics, Proteomics and Informatics, 1946. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_16780.
Beaumont, David. "Physical Health—Te Taha Tinana". In Positive Medicine, 111–20. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780192845184.003.0009.
Braunstein, Miriam, Scott G. Holmes, e James R. Broach. "Heterochromatin and regulation of gene expression in. Saccharomyces cerevisiae". In Nuclear Organization, Chromatin Structure, and Gene Expression, 250–75. Oxford University PressOxford, 1997. http://dx.doi.org/10.1093/oso/9780198549239.003.0015.
Atti di convegni sul tema "Telomere Position Effect":
Tempaku, P. F., V. D'Almeida, S. M. A. Silva, L. Bittencourt, S. I. Belangero e S. Tufik. "Effect of Continuous Positive Airway Pressure on Telomere Length and Its Associated Mechanisms". In XIX Congresso Brasileiro do Sono. Thieme Revinter Publicações Ltda., 2023. http://dx.doi.org/10.1055/s-0043-1770238.