Tesi sul tema "T cells"
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Carson, Bryan David. "Impaired T cell receptor signaling in regulatory T cells /". Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8337.
Testo completoLloyd, Angharad. "Gene editing in T-cells and T-cell targets". Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/98512/.
Testo completoStefkova, Martina. "Regulatory T cells control the CD4 T cell repertoire". Doctoral thesis, Universite Libre de Bruxelles, 2016. https://dipot.ulb.ac.be/dspace/bitstream/2013/233151/3/Table.pdf.
Testo completoRecent studies conducted in mice and humans have suggested a role for the TCR repertoire diversity in immune protection against pathogens displaying high antigenic variability. To study the CD4 T cell repertoire, we used a mouse model in which T cells transgenically express the TCRβ chain of a TCR specific to a MHCII-restricted peptide, env122-141. Upon immunization with peptide-pulsed dendritic cells, antigen-specific Vα2+ CD4+ T cells rapidly expand and display a restricted TCRα repertoire. In particular, analysis of receptor diversity by high-throughput TCR sequencing in immunized mice suggests the emergence of a broader CDR3 Vα2 repertoire in Treg-depleted mice. These results suggest that Tregs may play a role in the restriction of the CD4 T cell repertoire during an immune response, raising therefore the possibility that in addition to controlling the magnitude of an immune response, regulatory cells may also control the diversity of TCRs in response to antigen stimulation.
Doctorat en Sciences
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Butcher, Sarah A. "T cell receptor genes of influenza A haemagglutinin specific T cells". Thesis, University College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315271.
Testo completoCrawford, A. "How B cells influence T cell responses". Thesis, University of Edinburgh, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.645118.
Testo completoSarris, Milka. "Dynamics of helper T cell and regulatory T cell interactions with dendritic cells". Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611896.
Testo completoSmith, Trevor Robert Frank. "Modulation of CD4+ T cell responses by CD4+CD25+ regulatory T cells and modified T cell epitopes". Thesis, Imperial College London, 2004. http://hdl.handle.net/10044/1/11317.
Testo completoMurray, Nicholas. "Costimulation of T cells and its role in T cell recognition of malignant colorectal cells in vitro". Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301247.
Testo completoLi, Ming 1957. "Generation of CD8+ T cell immunity with help from CD4+ T cells". Monash University, Dept. of Pathology and Immunology, 2002. http://arrow.monash.edu.au/hdl/1959.1/8476.
Testo completoSoper, David Michael. "Interleukin-2 receptor and T cell receptor signaling in regulatory T cells /". Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8344.
Testo completoSommermeyer, Daniel. "Generation of dual T cell receptor (TCR) T cells by TCR gene transfer for adoptive T cell therapy". Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16051.
Testo completoThe in vitro generation of T cells with a defined antigen specificity by T cell receptor (TCR) gene transfer is an efficient method to create cells for immunotherapy. One major challenge of this strategy is to achieve sufficiently high expression levels of the therapeutic TCR. As T cells expressing an endogenous TCR are equipped with an additional TCR, there is a competition between therapeutic and endogenous TCR. Before this work was started, it was not known which TCR is present on the cell surface after TCR gene transfer. Therefore, we transferred TCR genes into murine and human T cells and analyzed TCR expression of endogenous and transferred TCR by staining with antibodies and MHC-multimers. We found that some TCR have the capability to replace other TCR on the cell surface, which led to a complete conversion of antigen specificity in one model. Based on these findings we proposed the concept of ‘‘strong’’ (well expressed) and “weak” (poorly expressed) TCR. In addition, we found that a mouse TCR is able to replace both “weak” and “strong” human TCR on human cells. In parallel to this result, it was reported that the constant (C)-regions of mouse TCR were responsible for the improved expression of murine TCR on human cells. This led to a strategy to improve human TCR by exchanging the C-regions by their murine counterparts (murinization). However, a problem of these hybrid constructs is the probable immunogenicity. Therefore, we identified the specific parts of the mouse C-regions which are essential to improve human TCR. In the TCRalpha C-region four and in the TCRbeta C-region five amino acids were identified. Primary human T cells modified with TCR containing these nine “murine” amino acids showed an increased function compared to cells modified with wild type TCR. For TCR gene therapy the utilization of these new C-regions will reduce the amount of foreign sequences and thus the risk of immunogenicity of the therapeutic TCR.
Nadal-Melsio, Elisabet. "Regulatory T cells after allogeneic stem cell transplantation". Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.523746.
Testo completoMahajan, Simmi. "Development of T cell help for B cells". Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/12548.
Testo completoMavin, Emily. "Regulatory T cells in haematopoietic stem cell transplantation". Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2731.
Testo completoRobertson, Anna-Karin L. "T cells in atherogenesis /". Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-032-X/.
Testo completoRobb, S. A. "T cells in myasthenia". Thesis, University of Newcastle Upon Tyne, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376234.
Testo completoCabbage, Sarah E. "Reversible regulatory T cell-mediated suppression of myelin basic protein-specific T cells /". Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/5034.
Testo completoWright, G. P. "Generation of antigen-specific regulatory T cells by T cell receptor gene transfer". Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/18952/.
Testo completoNagai, Yuya. "T memory stem cells are the hierarchical apex of adult T-cell leukemia". Kyoto University, 2015. http://hdl.handle.net/2433/202670.
Testo completoTerry, Alexandra Margaret. "The Roles of CD4+ T cells and Regulatory T cells in Antitumour Immunity". Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/17331.
Testo completoNishioka, Tomohisa. "CD4[+]CD25[+]Foxp3[+] T cells and CD4[+]CD25[-]Foxp3[+] T cells in aged mice". Kyoto University, 2007. http://hdl.handle.net/2433/135647.
Testo completoJavorovic, Miran. "T-Cell Stimulation by Melanoma RNA-Pulsed Dendritic Cells". Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-30569.
Testo completoBansal, Raj Rani. "B cell help provided by human γδ T cells". Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/36649/.
Testo completoCrawford, Alison. "Role of B cells in influencing T cell responses". Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/13483.
Testo completoMulati, Kumuluzi. "VISTA expressed in tumor cells regulates T cell function". Kyoto University, 2019. http://hdl.handle.net/2433/242370.
Testo completoRaeiszadeh, Mohammad. "Reconstitution of CMV-specific T-cells following adoptive T-cell immunotherapy and haematopoietic stem cell transplantation". Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6968/.
Testo completoKanazawa, Nobuo. "Fractalkine and macrophage-derived chemokine : T cell attracting chemokines expressed in T cell area dendritic cells". Kyoto University, 2000. http://hdl.handle.net/2433/180886.
Testo completoHimmel, Megan Elizabeth. "Phenotypic and functional characterization of T cells and Foxp3⁺ T regulatory cells in inflammatory bowel disease : steps towards T regulatory cell therapy in mucosal disease". Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42517.
Testo completoYe, Song Cheung H. Tak. "Identification of a thymic extracellular matrix protein that promotes strong thymocyte adhesion". Normal, Ill. Illinois State University, 1990. http://wwwlib.umi.com/cr/ilstu/fullcit?p9115234.
Testo completoTitle from title page screen, viewed December 2, 2005. Dissertation Committee: H. Tak Cheung (chair), Herman Brockman, Harry Huizinga, Anthony Otsuka, Brian Wilkinson. Includes bibliographical references (leaves 116-127) and abstract. Also available in print.
Salcido-Ochoa, Francisco. "Anergic T cells & immunoregulation". Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418002.
Testo completoTaylor, P. M. "Cytotoxic T-cells in influenza". Thesis, Brunel University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234171.
Testo completoMottet, Christian. "Biology of regulatory T cells". Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433353.
Testo completoThompson, Claire. "Characterisation of regulatory T cells". Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436941.
Testo completoHildalgo, Ester. "T cells in Rheumatoid Arthritis". Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/1715/.
Testo completoAloufi, Nawaf. "The role of sCD127 in IL-7-Mediated T Cell Homeostasis in Vivo". Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41089.
Testo completoFergusson, Joannah R. "Mucosal associated invariant T cells and related CD161 expressing T lymphocytes". Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:c5490bde-61c4-4715-bbf9-728ec9a8d51a.
Testo completoParra, Eduardo. "Molecular basis for costimulation of human T lymphocytes". Lund : Lund University, 1998. http://books.google.com/books?id=SgFrAAAAMAAJ.
Testo completoRivet, Catherine Aurelie. "Study of early signaling events in T cell activation enabled through a modular and multi-time point microfluidic device". Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/31674.
Testo completoCommittee Chair: Kemp, Melissa; Committee Member: Brand, Oliver; Committee Member: Lu, Hang. Part of the SMARTech Electronic Thesis and Dissertation Collection.
Kurioka, Ayako. "Mucosal associated invariant T cells and CD161 expressing natural killer cells". Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:f994e661-d241-4a1c-ac56-b6bea73346ac.
Testo completoDittmer, Marie. "Influence of regulatory T cells on oligodendrocyte lineage cells". Thesis, Queen's University Belfast, 2017. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.725831.
Testo completoGrero, Dhanya. "Cytotoxicity of Vγ9Vδ2 T cells towards Colon Cancer Cells". Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-230976.
Testo completoZheng, Biao. "Inductive interactions between antigen presenting cells and T cells". Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314796.
Testo completoKwong, Amelia. "Crosstalk Between T Cells, Dendritic Cells, Cytokines, and Chemokines". Thesis, The University of Arizona, 2010. http://hdl.handle.net/10150/146198.
Testo completoMühle, Kerstin. "Interaction of CD8+CD40L+ T cells with B cells". Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19127.
Testo completoCTLs are important for the elimination of infected and degenerated cells by inducing apoptosis of the target cells. Recently our group identified a sub-population of CD8+ T cells expressing CD40L instead of common CTL markers. To that date, transient CD40L expression on T cells has been only described as a function of activated CD4+ T cells, which displays this key molecule for CD4+ T cell mediated help by binding to the CD40 receptor on other immune cells. Particularly, CD40L signaling provided by CD4+ T cells is indispensable for T cell dependent B cell activation and GC responses, which generate B cells secreting high affinity antibodies that protect the host from invading pathogens. Due to its associated helper functions, this thesis aimed to dissect whether CD40L positive CD8+ T cells are restricted to cytotoxic killing or if this sub-population possesses similar properties as CD4+ T cells when interacting with B cells. In vitro co-culture experiments showed that 50% of murine antigen specific CD8+ T cells up-regulated CD40L upon activation by antigen presenting B cells. When compared to CD40L deficient CD8+ T cells, the interaction of CD8+ CD40L+ T cells induced remarkable changes in B cells on the RNA and protein level and triggered a B cell phenotype resembling that of B cells primed by CD4+ T cells. By the infection of mice with the B cell trophic virus MHV-68, it was found that E8IcrexCD40Lflox transgenic mice lacking CD40L only on matured CD8+ T cells, exhibited a significant decrease of GC B cells in superficial cervical lymph nodes at the acute state of infection compared to WT mice. A closer look into the memory B cell repertoire revealed a preferred usage of the murine IGHJ3 gene family that modifies the CDR3 and thus the recognition groove of the B cell antibody in E8IcrexCD40Lflox mice. In summary, this work provides sufficient evidence that CD8+ CD40L+ T cells adopt helper-like functions by supporting B cell activation and subsequent GC formation.
Le, Gouge Kenz. "Modelling the T-cell repertoires of circulating T-cells and its application in cardiovascular diseases". Electronic Thesis or Diss., Sorbonne université, 2023. http://www.theses.fr/2023SORUS705.
Testo completoCardiovascular diseases (CVD) are the leading cause of mortality in Europe, surpassing various cancers, and are a major current public health concern. The immune system is involved in the aetiology of these diseases. Among the many components of the immune system, T lymphocytes play a predominant role in the development, progression, or tissue repair of CVD. T lymphocytes carry out their function following their activation, which is determined by their ability to specifically recognise proteins or antigens, whether they are exogenous, such as those from pathogens or allergens, or endogenous, such as those from physiological cell renewal or tumour cells. This recognition is mediated by a specific receptor called the TCR, which stands for T-cell receptor. Unlike most genes, the TCR is generated through a random somatic recombination process involving around a hundred genes belonging to three major families: V for Variable, D for Diversity, and J for Junction. This unique mechanism, particular to genes encoding antigen-specific receptors, takes place in the thymus during the development and differentiation of T lymphocytes and results in the production of several billion different TCRs in an individual. This diversity forms the TCR repertoire and provides each individual with the ability to recognize any antigen, whether exogenous or endogenous, and initiate an immune response. Therefore, the TCR repertoire is shaped throughout an individual's life depending on variable and successive exposures to the antigenic environment they encounter. In the context of my thesis, my goal was to assess the connection between the composition of the TCR repertoire and its dynamics with the development and progression of cardiovascular diseases. First, I evaluated the reliability of sequencing technologies that allow for a detailed analysis of the TCR repertoire's composition through the quantification of sequences from thousands of TCRs. During this work, I developed a quality control tool that enabled me to identify a contamination phenomenon related to the sequencing platform utilizing the exclusion amplification technology and devised an algorithm for data detection and decontamination. Furthermore, I characterized the TCR repertoire in different cardiovascular disease (MCV) situations. Through a national collaboration, I characterized the circulating TCR repertoire in paediatric cases of multisystem inflammatory syndrome following COVID-19. This study was fundamental in confirming the remote superantigen effect of a Sars-CoV2 infection and demonstrating the relevance of TCR sequencing data in addition to clinical observations for diagnostic assistance. In an international collaboration, we had access to blood samples from patients who had experienced a myocardial infarction. The aim of my work was to identify, from the TCRs in these patients' blood, a set of TCRs capable of predicting cardiac repair in these patients. These efforts demonstrated the feasibility of a method to identify a TCR signature distinguishing good from poor repairers. Finally, in a second cohort of myocardial infarction patients, I explored the relevance of network analysis of TCRs for low-coverage sequencing data. These studies showed that the signatures associated with cardiac repair prognosis were not linked to TCRs known for cardiac specificity. Collectively, these results have helped to better define the possibilities that massive TCR sequencing can offer in the context of cardiovascular diseases
Murphy, Craig Antony. "Characterisation of T cells in rats that develop independently of the thymus : lymphocytes with potential regulatory roles /". Title page, abstract and contents only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phm9771.pdf.
Testo completoMay, Kenneth F. "T cell costimulation in anti-tumor immunity and autoimmunity". Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1085004772.
Testo completoDocument formatted into pages; contains xv, 178 p. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2006 May 20.
Ebert, Lisa Michelle. "The regulation of chemokine receptor expression upon T lymphocyte activation". Title page, contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phe165.pdf.
Testo completoRigby, Mark R. "R T 6: a Bifunctional Protein of Regulatory T Cells". eScholarship@UMMS, 1995. http://escholarship.umassmed.edu/gsbs_diss/283.
Testo completoSmits, Hermelijn Hélène. "Instruction of effector T cell programs by flexible dendritic cells". [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/86946.
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