Letteratura scientifica selezionata sul tema "Syntenin/syndecan interaction"
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Articoli di riviste sul tema "Syntenin/syndecan interaction":
Zimmermann, Pascale, Zhe Zhang, Gisèle Degeest, Eva Mortier, Iris Leenaerts, Christien Coomans, Joachim Schulz, Francisca N’Kuli, Pierre J. Courtoy e Guido David. "Syndecan Recyling Is Controlled by Syntenin-PIP2 Interaction and Arf6". Developmental Cell 9, n. 3 (settembre 2005): 377–88. http://dx.doi.org/10.1016/j.devcel.2005.07.011.
Zimmermann, Pascale, Zhe Zhang, Gisèle Degeest, Eva Mortier, Iris Leenaerts, Christien Coomans, Joachim Schulz, Francisca N’Kuli, Pierre J. Courtoy e Guido David. "Syndecan Recycling Is Controlled by Syntenin-PIP2 Interaction and Arf6". Developmental Cell 9, n. 5 (novembre 2005): 721. http://dx.doi.org/10.1016/j.devcel.2005.10.011.
BASS, Mark D., e Martin J. HUMPHRIES. "Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling". Biochemical Journal 368, n. 1 (15 novembre 2002): 1–15. http://dx.doi.org/10.1042/bj20021228.
Lee, Hawon, Yeonhee Kim, Youngsil Choi, Sojoong Choi, Eunkyung Hong e Eok-Soo Oh. "Syndecan-2 cytoplasmic domain regulates colon cancer cell migration via interaction with syntenin-1". Biochemical and Biophysical Research Communications 409, n. 1 (maggio 2011): 148–53. http://dx.doi.org/10.1016/j.bbrc.2011.04.135.
Imjeti, Naga Sailaja, Kerstin Menck, Antonio Luis Egea-Jimenez, Celine Lecointre, Frederique Lembo, Habib Bouguenina, Ali Badache et al. "Syntenin mediates SRC function in exosomal cell-to-cell communication". Proceedings of the National Academy of Sciences 114, n. 47 (6 novembre 2017): 12495–500. http://dx.doi.org/10.1073/pnas.1713433114.
Pradhan, Anjan K., Jinkal Modi, Santanu Maji, Amit Kumar, Praveen Bhoopathi, Padmanabhan Mannangatti, Chunqing Guo et al. "Abstract 3394: Simultaneous targeting of the PDZ1 and PDZ2 domains of MDA-9 inhibits melanoma metastasis". Cancer Research 83, n. 7_Supplement (4 aprile 2023): 3394. http://dx.doi.org/10.1158/1538-7445.am2023-3394.
Zhao, Tian, Xiaolan Yang, Guangfei Duan, Jialin Chen, Kefeng He, Yong‐Xiang Chen e Shi‐Zhong Luo. "Phosphorylation‐regulated phase separation of syndecan‐4 and syntenin promotes the biogenesis of exosomes". Cell Proliferation, 11 aprile 2024. http://dx.doi.org/10.1111/cpr.13645.
Pradhan, Anjan K., Jinkal Modi, Santanu Maji, Amit Kumar, Praveen Bhoopathi, Padmanabhan Mannangatti, Chunqing Guo et al. "Dual Targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin Inhibits Melanoma Metastasis". Molecular Cancer Therapeutics, 18 settembre 2023, OF1—OF13. http://dx.doi.org/10.1158/1535-7163.mct-22-0653.
Hoffer, Laurent, Manon Garcia, Raphael Leblanc, Mikael Feracci, Stéphane Betzi, Khaoula Ben Yaala, Avais M. Daulat et al. "Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein–Protein Interaction: A Semi-Automated “Hit Identification-to-Optimization” Approach". Journal of Medicinal Chemistry, 20 marzo 2023. http://dx.doi.org/10.1021/acs.jmedchem.2c01569.
Liu, Jing, Weiwei Bai, Tianxing Zhou, Yongjie Xie, Bo Yang, Jingyan Sun, Yifei Wang et al. "SDCBP promotes pancreatic cancer progression by preventing YAP1 from β-TrCP-mediated proteasomal degradation". Gut, 24 febbraio 2023, gutjnl—2022–327492. http://dx.doi.org/10.1136/gutjnl-2022-327492.
Tesi sul tema "Syntenin/syndecan interaction":
Garcia, Manon. "Développement de nouveaux agents anticancéreux inhibiteurs de la syntenin". Electronic Thesis or Diss., Aix-Marseille, 2021. http://theses.univ-amu.fr.lama.univ-amu.fr/210312_GARCIA_59el396udxeux306vl471dzd_TH.pdf.
The thesis describes the identification and optimization of selective inhibitors targeting the syntenin/syndecan complex, using a “Fragment-based drug design” (FBDD) strategy, which could pave the way for new anticancer therapies. The syntenin/syndecan interaction plays a major role in the recycling of endosomes to the plasma membrane, as well as in the biogenesis and release of exosomes derived from tumor cells. Therefore, we performed an FBDD program targeting selectively the syntenin/syndecan interaction. To do this, two different fragment library screenings were performed, one experimental the other virtual, and two fragments hits were identified that specifically inhibit the interaction of the syntenin/syndecan complex. The resolution of 3D crystallographic structures of the complexes between these two fragments and syntenin allowed their optimization by a structure-based drug design approach based on information about their binding site and the mode. SAR studies and fragment growing optimization steps, based on molecular docking studies, were carried out. My work consisted in synthesizing chemical libraries of targeted analogues resulting from molecular docking and demonstrating strong interactions with syntenin. Among all the synthesized analogues, we identified the most promising inhibitors which exhibit sub-micromolar IC50 and which affect the release pathway of exosomes derived from tumor cells, dependent on syntenin/syndecan activity