Tesi sul tema "Structure-Based approaches"
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Vankayala, Sai Lakshmana Kumar. "Computational Approaches for Structure Based Drug Design and Protein Structure-Function Prediction". Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4601.
Testo completoTosatto, Silvio Carlo Ermanno. "Protein structure prediction improving and automating knowledge-based approaches /". [S.l. : s.n.], 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10605023.
Testo completoEmami, Fatemesadat. "Prediction of Thermodynamic Properties by Structure-Based Group Contribution Approaches". University of Akron / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1217270074.
Testo completoSelmadji, Anfel. "From monolithic architectural style to microservice one : structure-based and task-based approaches". Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTS026/document.
Testo completoSoftware technologies are constantly evolving to facilitate the development, deployment, and maintenance of applications in different areas. In parallel, these applications evolve continuously to guarantee an adequate quality of service, and they become more and more complex. Such evolution often involves increased development and maintenance costs, that can become even higher when these applications are deployed in recent execution infrastructures such as the cloud. Nowadays, reducing these costs and improving the quality of applications are main objectives of software engineering. Recently, microservices have emerged as an example of a technology or architectural style that helps to achieve these objectives.While microservices can be used to develop new applications, there are monolithic ones (i.e., monoliths) built as a single unit and their owners (e.g., companies, etc.) want to maintain and deploy them in the cloud. In this case, it is common to consider rewriting these applications from scratch or migrating them towards recent architectural styles. Rewriting an application or migrating it manually can quickly become a long, error-prone, and expensive task. An automatic migration appears as an evident solution.The ultimate aim of our dissertation is contributing to automate the migration of monolithic Object-Oriented (OO) applications to microservices. This migration consists of two steps: microservice identification and microservice packaging. We focus on microservice identification based on source code analysis. Specifically, we propose two approaches.The first one identifies microservices from the source code of a monolithic OO application relying on code structure, data accesses, and software architect recommendations. The originality of our approach can be viewed from three aspects. Firstly, microservices are identified based on the evaluation of a well-defined function measuring their quality. This function relies on metrics reflecting the "semantics" of the concept "microservice". Secondly, software architect recommendations are exploited only when they are available. Finally, two algorithmic models have been used to partition the classes of an OO application into microservices: clustering and genetic algorithms.The second approach extracts from an OO source code a workflow that can be used as an input of some existing microservice identification approaches. A workflow describes the sequencing of tasks constituting an application according to two formalisms: control flow and /or data flow. Extracting a workflow from source code requires the ability to map OO conceptsinto workflow ones.To validate both approaches, we implemented two prototypes and conducted experiments on several case studies. The identified microservices have been evaluated qualitatively and quantitatively. The extracted workflows have been manually evaluated relying on test suites. The obtained results show respectively the relevance of the identified microservices and the correctness of the extracted workflows
Stehr, Henning [Verfasser]. "Graph-based approaches to protein structure- and function prediction / Henning Stehr". Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1026266157/34.
Testo completoBIANCO, GIULIA. "Structure-based approaches applied to the study of pharmaceutical relevant targets". Doctoral thesis, Università degli Studi di Cagliari, 2016. http://hdl.handle.net/11584/266709.
Testo completoAnnadurai, Sivakumar. "Lead generation using a privileged structure-based approach". Diss., Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/213119.
Testo completoPh.D.
In drug discovery there are several approaches to lead generation and one traditional approach involves the synthesis and screening of a structurally diverse compound library against a number of biological targets to identify high affinity lead compounds. The use of a `privileged' structure-based compound library represents a viable approach that could lead to drug like lead compounds. Privileged structures are defined as those ligand substructures that may be used to generate high affinity leads for more than one type of receptor. Examples of privileged structures include phenyl substituted monocycles such as biphenyls, diphenyl methane derivatives, 1,4-dihydropyridines, fused ring systems such as chromones, quinoxalines, quinazolines, 2-benzoxazolones, indoles, benzimidazoles and benzofurans. There are several instances in the literature describing the development of compound libraries based on privileged structures with reportedly high hit rates. Privileged structure based approaches has been used with notable success in the identification of high affinity ligands especially for G-protein coupled receptors (GPCRs). The scaffold 2-aminothiazole (fused and non-fused) may be considered a privileged structure because of its occurrence in a wide variety of pharmaceuticals. The scaffold is found in antibacterials, anti-inflammatory agents, glutamate transporter (GLT-1) modulators, serotonin and muscarinic ligands. The present study involves the synthesis of a 2-aminothiazole (fused and non-fused) based compound library (60 compounds) by incorporating bioactive fragments shown to produce hits in the biological targets of interest. Microwave assisted organic synthesis (MAOS) has been employed at key steps of scaffold synthesis as well as in Suzuki coupling to generate the target aminothiazoles. Preliminary biological screening has resulted in the identification of some promising lead compounds. Trifluoromethoxy substituted aminothiazoles were found to be potent antimicrobials with MIC values in the range of 4-16 microgram/ml. Furanone based aminothiazoles showed affinity for muscarinic receptors. Piperidine based aminothiazoles showed greater than 90% of control (8-OH-DPAT) specific agonist response at the 5-HT1A receptor subtype. The Clog P values of the most potent antimicrobials were found to be in the range of 4.5-6.2 indicating the high lipophilicity of the compounds. High lipophilicity is known to cause solubility issues that may hamper future development. Therefore in an effort to make compounds with intermediate lipophilicity, the phenyl core of the potent aminothiazoles will be replaced with pyridine core using literature procedures (Pyridine core containing aminothiazoles showed Clog P < 4). Future plans include expanding the library, improving the yields of compounds and to evaluate the compounds as modulators of glutamate transporter (GLT-1). The work could be extended to include other privileged structures such as 2-aminooxazole, 2-aminobenzoxazole, 2-aminoimidazole and 2-aminobenzimidazole. These mono and bicyclic heterocyles may be considered bioisosteres of 2-aminothiazole.
Temple University--Theses
Rosenberger, David. "From the bottom up - A systematic study of structure based coarse graining approaches". Phd thesis, TUprints, 2019. https://tuprints.ulb.tu-darmstadt.de/8509/1/Phd_thesis.pdf.
Testo completoCheca, Ruano Luis. "Structure-based design of antiviral drugs against respiratory viruses using in silico approaches". Electronic Thesis or Diss., Sorbonne université, 2024. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2024SORUS0743.pdf.
Testo completoProtein-Protein interactions (PPI) play crucial roles in many biological pathways and are being increasingly explored as potential therapeutic targets, including for treating infectious diseases. However, designing small molecule modulators for PPI remains challenging as PPI interfaces have not evolved to bind small molecules like conventional drug targets such as enzymes or membrane receptors. Therefore, proof of their druggability must be made on a case-by-case basis. In this context, computational approaches can be useful in assisting the design of PPI modulators.This work aims to develop new in silico drug design protocols specifically tailored to PPI targets, with the goal of designing new antiviral drugs against two PPI targets: the respiratory syncytial virus (RSV) and the SARS-CoV-2
Speidel, Joshua A. "Computational approaches to structure based ligand design : an illustration for P/CAF bromodomain ligands /". Access full-text from WCMC, 2007. http://proquest.umi.com/pqdweb?did=1453183061&sid=21&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Testo completoSmith, Breland Elise. "Small Molecule Approaches Toward Therapeutics for Alzheimer's Disease and Colon Cancer". Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/337213.
Testo completoCuzzolin, Alberto. "Novel in silico approaches to depict the protein-ligand recognition events". Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424818.
Testo completoLa scoperta e la commercializzazione di un nuovo farmaco è un processo lungo e dispendioso, che si articola in diverse fasi durante le quali vengono determinate le proprietà fisiche, chimiche e terapeutiche dei composti investigati. In particolare, nella prima fase di questo processo si cerca di verificare che il composto riconosca e interagisca efficacemente con la proteina bersaglio. A tale scopo, negli ultimi decenni numerosi strumenti computazionali sono stati sviluppati e utilizzati per supportare i ricercatori che si adoperano nella parte sperimentale. I problemi affrontati presentano un alto livello di complessità, che sarebbero difficili da studiare in toto, perciò gli sviluppatori di metodi e algoritmi devono necessariamente adottare notevoli semplificazioni. Inoltre, le risorse di calcolo (hardware) determinano le tempistiche con le quali è possibile ottenere il risultato richiesto. In tal senso, lo sviluppo tecnologico ha portato a un importante aumento della potenza di calcolo a costi accessibili, stimolando l’interesse per lo sviluppo di tecniche sempre più complesse. Durante questo progetto di dottorato ci si è focalizzati sullo sviluppo e il miglioramento di metodi in silico, che permettono di rispondere ad alcuni interrogativei a costi e tempistiche di molto ridotte. Inoltre, tali metodi sono stati implementati in software dotati di interfaccia grafica (GUI) al fine di poter aiutare l’utente nel loro utilizzo. Le tecniche computazionali spesso richiedono un’elevata conoscenza teorica delle metodologie e anche una certa competenza informatica, come la gestione di diversi tipologie di file e delle risorse hardware da impiegare. Per questo motivo i software da noi sviluppati sono stati organizzati in pipelines, in modo da automatizzare l’intero processo e rendere questi strumenti fruibili anhce a persone non esperte. Infine, l’utilità di queste nuove metodologie è stata comprovata in progetti in cui questi strumenti hanno permesso di delucidare aspetti interessanti e fino ad ora non ancora accessibili nell’ambito del riconoscimento proteina-ligando.
Sarti, Edoardo. "Assessing the structure of proteins and protein complexes through physical and statistical approaches". Doctoral thesis, SISSA, 2015. http://hdl.handle.net/20.500.11767/4863.
Testo completoIOVINELLI, DANIELE. "Structure-based approaches for the rapid identification of tumor microenvironment nutrients, inhibitors and allosteric modulators against soluble and membrane proteins". Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1203165.
Testo completoMardhiah, Ulfah [Verfasser]. "Determination of biotic and abiotic factors influencing soil structure development in a riparian system based on observational and experimental approaches / Ulfah Mardhiah". Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1068504838/34.
Testo completoRosenberger, David [Verfasser], Nico van der [Akademischer Betreuer] Vegt e Martin [Akademischer Betreuer] Hanke-Bourgeois. "From the bottom up - A systematic study of structure based coarse graining approaches / David Rosenberger ; Nico van der Vegt, Martin Hanke-Bourgeois". Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2019. http://d-nb.info/1186258497/34.
Testo completoCarreno, Velazquez Thalia Lizbeth. "Structure-based drug discovery approaches to identify modulators of the Nrf2 pathway and glutamate receptors AMPA GluA2 and Kainate GluK1 and GluK2". Thesis, University of Sussex, 2018. http://sro.sussex.ac.uk/id/eprint/75046/.
Testo completoManzenrieder, Florian. "New approaches to discover protease inhibitors : by de novo rational structure based design (BACE1) and by development and use of 1̲hn31̲hn1P NMR as versatile tool to screen compound libraries /". München : Verl. Dr. Hut, 2009. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=017356959&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Testo completoVerrastro, Ivan. "The redoxomics of PTEN : walking a fine line between damage and signaling : mass spectrometry-based approaches to study the effect of oxidation on PTEN function, structure, and protein-protein interactions". Thesis, Aston University, 2016. http://publications.aston.ac.uk/28891/.
Testo completoRyan, A. "Adult learner strategies in foreign language grammar learning : A task-based study of approaches to the learning of grammatical structure in a micro-language, with a discussion of their implications for language teaching and materials". Thesis, University of Edinburgh, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375802.
Testo completoBae, Kyounghwa. "Bayesian model-based approaches with MCMC computation to some bioinformatics problems". Texas A&M University, 2005. http://hdl.handle.net/1969.1/2396.
Testo completoPanei, Francesco Paolo. "Advanced computational techniques to aid the rational design of small molecules targeting RNA". Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS106.
Testo completoRNA molecules have recently gained huge relevance as therapeutic targets. The direct targeting of RNA with small molecule drugs emerges for its wide applicability to different classes of RNAs. Despite this potential, the field is still in its infancy and the number of available RNA-targeted drugs remains limited. A major challenge is constituted by the highly flexible and elusive nature of the RNA targets. Nonetheless, RNA flexibility also presents unique opportunities that could be leveraged to enhance the efficacy and selectivity of newly designed therapeutic agents. To this end, computer-aided drug design techniques emerge as a natural and comprehensive approach. However, existing tools do not fully account for the flexibility of the RNA. The project of this PhD work aims to build a computational framework toward the rational design of compounds targeting RNA. The first essential step for any structure-based approach is the analysis of the available structural knowledge. However, a comprehensive, curated, and regularly updated repository for the scientific community was lacking. To fill this gap, I curated the creation of HARIBOSS ("Harnessing RIBOnucleic acid - Small molecule Structures"), a database of all the experimentally-determined structures of RNA-small molecule complexes retrieved from the PDB database. HARIBOSS is available via a dedicated web interface (https://hariboss.pasteur.cloud), and is regularly updated with all the structures resolved by X-ray, NMR, and cryo-EM, in which ligands with drug-like properties interact with RNA molecules. Each HARIBOSS entry is annotated with physico-chemical properties of ligands and RNA pockets. HARIBOSS repository, constantly updated, will facilitate the exploration of drug-like compounds known to bind RNA, the analysis of ligands and pockets properties and, ultimately, the development of in silico strategies to identify RNA-targeting small molecules. In coincidence of its release, it was possible to highlight that the majority of RNA binding pockets are unsuitable for interactions with drug-like molecules, attributed to the lower hydrophobicity and increased solvent exposure compared to protein binding sites. However, this emerges from a static depiction of RNA, which may not fully capture their interaction mechanisms with small molecules. In a broader perspective, it was necessary to introduce more advanced computational techniques for an effective accounting of RNA flexibility in the characterization of potential binding sites. In this direction, I implemented SHAMAN, a computational technique to identify potential small-molecule binding sites in RNA structural ensembles. SHAMAN enables the exploration of the target RNA conformational landscape through atomistic molecular dynamics. Simultaneously, it efficiently identifies RNA pockets using small probe compounds whose exploration of the RNA surface is accelerated by enhanced-sampling techniques. In a benchmark encompassing diverse large, structured riboswitches as well as small, flexible viral RNAs, SHAMAN accurately located experimentally resolved pockets, ranking them as preferred probe hotspots. Notably, SHAMAN accuracy was superior to other tools working on static RNA structures in the realistic drug discovery scenario where only apo structures of the target are available. This establishes SHAMAN as a robust platform for future drug design endeavors targeting RNA with small molecules, especially considering its potential applicability in virtual screening campaigns. Overall, my research contributed to enhance our understanding and utilization of RNA as a target for small molecule drugs, paving the way for more effective drug design strategies in this evolving field
Abdalla, Hassan Hamed. "An intelligent multi-controller structure : a knowledge-based approach". Thesis, University of Newcastle Upon Tyne, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387245.
Testo completoGreco, T. "NETWORK META-ANALYSIS: A NOVEL APPROACH BASED ON A HIERARCHICAL DATA STRUCTURE". Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/344198.
Testo completoHossain, Muhammad Shazzad. "New mechanism-based design approaches for spudcan foundations in clay". University of Western Australia. School of Civil and Resource Engineering, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0103.
Testo completoSadawi, Noureddin. "A rule-based approach for recognition of chemical structure diagrams". Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4325/.
Testo completoAbdul, Shukor Shazmin. "A geometrical-based approach to recognise structure of complex interiors". Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/55722/.
Testo completoVillemagne, Baptiste. "Conception, synthèse et dévelopement d'inhibiteurs du répresseur transcriptionnel mycobactérien ETHR selon une approche par fragments. Une nouvelle approche dans la lutte contre la tuberculose". Thesis, Lille 2, 2012. http://www.theses.fr/2012LIL2S052/document.
Testo completoTuberculosis (TB) remains the leading cause of death due to a single infective agent with more than 1.5 million people killed each year. In 2011, the world health organization (WHO) estimated that one third of the world’s population is infected with Mycobacterium tuberculosis, the pathogen responsible for the disease. This phenomenon may be due to an explosive escalation of TB incidence that occurred in the 1980s due to the emergence of both resistant strains and HIV epidemic.In 2000, EthR, a mycobacterial transcriptional repressor, was identified as a key modulator of ethionamide (ETH) bioactivation. ETH is one of the main second-line drugs used to treat drug resistant strains. In 2009, it was shown that co-administration of ETH and drug-like inhibitors of EthR was able to boost ETH activity threefold in a mouse-model of TB-infection, thus validating the target for a new therapeutic strategy.This work deals with the discovery and optimisation of new EthR inhibitors, based on a small molecule, called a “fragment”, co-crystallized with the protein. We combined in silico screening, in vitro evaluation of the hit compounds, study of co-crystal structures and medicinal chemistry to develop three complementary approaches called “fragment growing”, “fragment merging” and “fragment linking” that led to the discovery of very potent inhibitors. Based on these results, we are currently selecting a potential candidate for new in vivo experiments
Pekilis, Barry. "An Ontology-Based Approach To Concern-Specific Dynamic Software Structure Monitoring". Thesis, University of Waterloo, 2006. http://hdl.handle.net/10012/2836.
Testo completoThis thesis introduces ResOwn - an application resource ownership ontology for interactive session-oriented services. ResOwn provides software monitoring with enriched concepts of application resource ownership borrowed from real-world legal and ownership ontologies. ResOwn is formally defined in OWL-DL (Web Ontology Language Description Logic), verified using an off-the-shelf reasoner, and tested using the call processing software for a small private branch exchange (PBX). The ResOwn Prime Directive states that every object in an operational software system is a resource, an owner, or both simultaneously. Resources produce benefits. Beneficiary owners may receive resource benefits. Nonbeneficiary owners may only manage resources. This approach distinguishes resource ownership use from management and supports the ability to detect when a resource's role-based runtime capacity has been exceeded.
This thesis also presents a greybox approach to concern-specific, dynamic software structure monitoring including a monitor architecture, greybox interpreter, and algorithms for deriving monitoring model from a monitored target's formal specifications. The target's requirements and design are assumed to be specified in SDL, a formalism based on communicating extended finite state machines. Greybox abstraction, applicable to both behavior and structure, provides direction on what parts, and how much of the target to instrument, and what types of resource errors to detect.
The approach was manually evaluated using a number of resource allocation and ownership scenarios. These scenarios were obtained by collecting actual call traces from an instrumented PBX. The results of an analytical evaluation of ResOwn and the monitoring approach are presented in a discussion of key advantages and known limitations. Conclusions and recommended future work are discussed at the end of the thesis.
Mirzoev, Alexander. "Multiscale simulations of soft matter: systematic structure-based coarse-graining approach". Doctoral thesis, Stockholms universitet, Institutionen för material- och miljökemi (MMK), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-94756.
Testo completoAt the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 4: Submitted.
Chimni, Jasbinder Singh Carleton University Dissertation Management Studies. "An approach to computer-based support for work breakdown structure development". Ottawa, 1989.
Cerca il testo completoDi, Lascio Francesca Marta Lilja <1979>. "Analyzing the dependence structure of microarray data: a copula–based approach". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/670/1/Tesi_Di_Lascio_Francesca_Marta_Lilja.pdf.
Testo completoDi, Lascio Francesca Marta Lilja <1979>. "Analyzing the dependence structure of microarray data: a copula–based approach". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/670/.
Testo completoGüell, Riera Oriol. "A network-based approach to cell metabolism: from structure to flux balances". Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/292364.
Testo completoLa visió completa del metabolisme cel·lular, és a dir, tenint en compte totes les reaccions que el componen, permet descobrir nous mecanismes i respostes que són impossibles d’obtenir amb els mètodes reduccionistes tradicionals. L’estudi d’una xarxa metabòlica completa requereix eines que pertanyen a la Biologia de Sistemes i a la Ciència de les Xarxes Complexes. La present tesi mostra com la combinació de les eines que pertanyen a aquests dos camps es pot aplicar per a descobrir noves propietats de les xarxes metabòliques. D'aquesta manera, s’han estudiat les xarxes metabòliques de tres bacteris amb les següents eines: (1) algoritme de cascada, que es pot usar per estudiar si les xarxes metabòliques poden sobreviure a inactivacions de determinades reaccions, (2) Flux Balance Analysis, que s’usa per a calcular els fluxos a través de les reaccions que composen la xarxa metabòlica suposant que l’objectiu biològic de l’organisme a estudiar és maximitzar la velocitat de creixement, (3) Disparity Filter, que permet obtenir versions reduïdes de xarxes metabòliques, cosa que facilita el seu estudi i anàlisi, i (4) Hit-And-Run, que permet obtenir totes les solucions metabòliques independentment de que maximitzin el creixement de l’organisme. En aquesta tesi es demostra que el metabolisme de les cèl·lules dels organismes vius ha evolucionat de forma que aconsegueix sobreviure a les inactivacions de les reaccions que el componen. Addicionalment, s’identifiquen les rutes metabòliques responsables dels processos evolutius i adaptatius que es donen en les xarxes metabòliques. A més, també es demostra que la tècnica Flux Balance Analysis dóna una solució de fluxos que no es representativa de totes les possibles solucions. Cal remarcar que això no invalida la tècnica, sinó que les assumpcions que usa donen una solució concreta que té sentit biològic però que és molt diferent de la resta de solucions. És important recalcar que els resultats obtinguts en aquesta tesi podrien emprar-se en aplicacions mèdiques, per exemple estudiar el metabolisme de les cèl·lules cancerígenes, que podia utilitzar-se per a que aquestes cèl·lules no proliferin en el cos dels humans, un fet que causa moltes problemes en l'ésser humà.
Hench, Jürgen Christian Hans. "A combined threading and genetic algorithm based approach to predict protein structure". [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976774739.
Testo completoBratcher, Holly Bea. "Meningococcal genome dynamics : an allele based, population approach to define lineage structure". Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:08db20f8-2bda-4322-a6bc-5745139bbbad.
Testo completoHong, Soonyoung. "An effective data mining approach for structure damage indentification". The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1194903908.
Testo completoSALAM, ABDUL. "Model-based and data-based frequency domain design of fixed structure robust controller: a polynomial optimization approach". Doctoral thesis, Politecnico di Torino, 2022. https://hdl.handle.net/11583/2972836.
Testo completoBrucet, Balmaña Sandra. "Zooplankton structure and dynamics in Mediterranean marshes (Empordà Wetlands): a size-based approach". Doctoral thesis, Universitat de Girona, 2003. http://hdl.handle.net/10803/7649.
Testo completoIn temporary basins the shape of the biomass-size spectra is related to the hydrological cycle. Linear shape spectra are more frequent in flooding situations when nutrient input causes population growth of small-sized organisms, more than compensating for the effect of competitive interactions. During confinement conditions the scarcity of food would decrease zooplankton growth and increase intra- and interspecific interactions between zooplankton organisms which favour the greatest sizes thus leading to the appearance of curved shape spectra.
Temporary and permanent basins have similar taxonomic composition but the latter have higher species diversity, a more simplified temporal pattern and a size distribution dominated mainly by smaller sizes. In permanents basins zooplankton growth is not only conditioned by the availability of resources but by the variable predation of planktivorous fish, so that the temporal variability of the spectra may also be a result of temporal differences in fish predation.
Size diversity seems to be a better indicator of the degree of this community structure than species diversity. The tendency of size diversity to increase during succession makes it useful to discriminate between different succession stages, fact that is not achieved by analysing only species diversity since it is low both under large and frequent or small and rare disturbances.
Amino acid composition differences found among stages of copepod species indicate a gradual change in diet during the life cycle of these copepods, which provide evidence of food niche partitioning during ontogeny, whereas Daphnia species show a relatively constant amino acid composition. There is a relationship between the degree of trophic niche overlap among stages of the different species and nutrient concentration. Copepods, which have low trophic niche overlap among stages are dominant in food-limited environments, probably because trophic niche partitioning during development allow them to reduce intraspecific competition between adults, juveniles and nauplii. Daphnia species are only dominant in water bodies or periods with high productivity, probably due to the high trophic niche overlap between juveniles and adults. These findings suggest that, in addition to the effect of interspecific competition, predation and abiotic factors, the intraspecific competition might play also an important role in structuring zooplankton assemblages.
L'estructura de la comunitat zooplanctònica dels Aiguamolls de l'Empordà, composició específica, dinàmica, diversitat i relacions tròfiques, s'ha estudiat a partir d'una aproximació basada en la mida.
L'aproximació s'ha basat en la modelització de l'espectre de mida-biomassa de la comunitat zooplanctònica a partir de la distribució de Pareto. S'ha observat que la forma de l'espectre de mida-biomassa del zooplàncton canvia segons les condicions ambientals: en situacions d'entrada d'aigua són més freqüents els espectres lineals ja que les entrades de nutrients causen un creixement dels organismes de mida petita de manera que es sobrecompensa l'efecte de les interaccions competitives. Els espectres corbats són més freqüents en situacions de confinament quan els recursos són escassos i les interaccions ecològiques entre els organismes prenen més rellevància de manera que es veuen més afavorides les espècies de mida gran que les de mida petita.
Les comunitats zooplanctòniques de les diferents llacunes de la maresma tenen una composició taxonòmica similar però una diversitat d'espècies, un patró estacional i una distribució de mides diferents. En el patró estacional de les llacunes temporànies es poden distingir sis situacions que estan condicionades per el cicle hidrològic i dominades per les següents espècies: Synchaeta spp, Diacyclops bicuspidatus, Eurytemora velox. Calanipeda aquae-dulcis, Cletocamptus confluens i Brachionus plicatilis. La llacuna permanent, tot i presentar una diversitat més alta que les temporànies, té un patró estacional més simple, amb només dues situacions: la situació de Synchaeta spp. i la de C. aquae-dulcis. Aquest patró estacional més reduït i una distribució de mides dominada principalment per organismes de mida petita s'explicarien per la pressió de depredació dels peixos en aquesta llacuna. Així, la variació en la forma de l'espectre de mida-biomassa de les comunitats zooplanctòniques de la llacuna permanent no està únicament relacionat amb el cicle higrològic sinó amb la pressió de depredació dels peixos.
La distribució de Pareto es pot utilitzar per calcular un índex de diversitat de mides (μs'). En el cas de la comunitat de zooplàncton la diversitat de mides ha resultat ser un millor indicador del nivell d'estructuració que la diversitat d'espècies, els augments de la qual moltes vegades no són deguts a una elevada estructuració de la comunitat. La tendència a augmentar al llarg de la successió fa que la diversitat de mides pugui discriminar entre diferents estadis de la successió, en canvi això no es possible a partir de la diversitat d'espècies ja que pot assolir valors elevats tant en moments de pertorbacions elevades i freqüents com en moments de pertorbacions petites i escasses. En llacunes temporànies, valors alts de diversitat de mides coincideixen en períodes de dominància d'una espècie de calanoid, períodes que representen les situacions més estables en aquestes llacunes.
L'anàlisi de la composició d'aminoàcids (AAC) ens demostra que les espècies de copèpodes dominants als Aiguamolls de l'Empordà mostren un canvi gradual en la seva composició bioquímica al llarg de la seva ontogènesi. Aquestes diferències en la AAC entre estadis no són degudes a diferències filogenètiques ni a les condicions ambientals, sinó a variacions en la dieta. Així, les diferents espècies de copèpodes mostren una repartició del nínxol tròfic entre els seus estadis de desenvolupament. Pel que fa a les espècies de dàfnids, mostren una AAC relativament constant durant el seu desenvolupament, fet que indicaria que tot els estadis s'alimenten del mateix recurs, és a dir, que juvenils i adults mostren un solapament del nínxol tròfic. La relació trobada entre la concentració de nutrients de les llacunes i el grau de solapament entre estadis de les espècies dominants mostra que la repartició del nínxol tròfic entre joves i adults és un possible mecanisme per tal d'evitar la competència intraespecífica. Els copèpodes, que tenen un baix solapament entre estadis, dominen en ambients on el recurs és limitat ja que la repartició del nínxol tròfic durant el desenvolupament els permet reduir la competència per l'aliment entre estadis. En les espècies de dàfnids, l'elevat solapament entre joves i adults els restringeix en llacunes o períodes amb elevada productivitat per tal d'evitar la competència intraespecífica. Així doncs, la competència intraespecífica juga un paper important a l'hora d'estructurar la comunitat de zooplàncton, juntament amb els dos altres factors que sovint són citats, la depredació i la competència interspecífica.
Boulkeroua, Wassila Abdelli. "The application of the fragment-based screening approach to RmlA protein and PA1645 structure". Thesis, University of St Andrews, 2013. http://hdl.handle.net/10023/4477.
Testo completoO'Leary, Brian. "A Vertex-Based Approach to the Statistical and Machine Learning Analyses of Brain Structure". University of Toledo / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1576254162111087.
Testo completoZHU, SHICHAO. "RECURSIVE MULTI-MODEL UPDATING OF BUILDING STRUCTURE: A NEW SENSITIVITY BASED FINITE ELEMENT APPROACH". Doctoral thesis, Politecnico di Torino, 2016. http://hdl.handle.net/11583/2643111.
Testo completoThomas, Sherine Elizabeth. "Targeting Mycobacterium abscessus infection in cystic fibrosis : a structure-guided fragment-based drug discovery approach". Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289126.
Testo completoNguyen, Khac Duy. "Structural damage identification using experimental modal parameters via correlation approach". Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/117289/2/Khac%20Duy%20Nguyen.pdf.
Testo completoAshkani, Zadeh Kianosh. "Seismic analysis of the RC integral bridges using performance-based design approach including soil structure interaction". Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45407.
Testo completoMohammadhosseini, Ali. "A search for optimal structure of carbon-based porous adsorbents for hydrogen storage : numerical modeling approach". Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4736.
Testo completoThe main goal of research presented in this thesis has been a search for optimal carbon-based porous structure capable to achieve the hydrogen storage capacity defined by US Department of Energy (DOE) for mobile applications at room temperature by adsorption at medium-level pressures below 120 bars. The hydrogen is assumed to be stored in a tank filled with adsorbents to be used in transport application, mainly fuel-cell driven vehicles. The known carbon-based adsorbents have low storage capacity. Therefore in this work, I have defined the basic parameters which are responsible for the capacity deficiency of such materials. Special attention has been paid to local pore geometry of adsorbents. I have investigated the pore local structure of carbon-based adsorbents and I present the basis of design and hydrogen adsorption capacity in three-dimensional architecture of new carbon frameworks, a promising class of potential hydrogen storage materials that have not been studied so far. Apart from maximizing the density of hydrogen taken up by this family of structures, I have aimed at characterization of this new category of adsorbents. This is hoped to lead to a guidance how their physical properties can be designed, or `tuned', to optimize their storage properties, and the obtained results seem to achieve this aim and thus provide a good basis for future research
LA, MONICA Gabriele. "Correlation between cell line chemosensitivity and protein expression pattern as new approach for the design of targeted anticancer small molecules". Doctoral thesis, Università degli Studi di Palermo, 2022. https://hdl.handle.net/10447/573085.
Testo completoDonnelly, Stephen Kevin. "Ethnic identity redefinition during acquisition of one's ancestral language (Irish) : an approach based on identity structure analysis". Thesis, University of Ulster, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259582.
Testo completoMcCoy, D. B. "Identity transition in persons undergoing elective interval sterilisation and vasectomy : An approach based on identity structure analysis". Thesis, University of Ulster, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378751.
Testo completoRuiz-Gómez, Gloria, John C. Hawkins, Jenny Philipp, Georg Künze, Robert Wodtke, Reik Löser, Karim Fahmy e M. Teresa Pisabarro. "Rational Structure-Based Rescaffolding Approach to De Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics". Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-215877.
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