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1
Burn, Sally. "Origin and morphogenesis of the murine spleen". Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/23965.
Testo completoAbstract (sommario):
This thesis establishes methods to investigate early spleen development in the mouse embryo. An expression analysis of early Nkx2.5 expression is reported, along with the finding that Nkx2.5 may be the earliest marker of splenic precursors in the mouse. Expression of Nkx2.5 is also shown for the first time to overlap considerably with that of Nkx3.2 – a major gut development gene upstream of Nkx2.5. An in silico analysis of the evolutionary conserved regions upstream of Nkx2.5 is presented along with the establishment and analysis of stable transgenic reporter lines expressing LacZ under the control of an Nkx2.5 gut regulatory sequence (NGRS). NGRS confers spleen, posterior stomach, and pyloric sphincter expression, with very little of the cardiac expression associated with endogenous Nkx2.5. This enhancer is thus ideal for gut studies, providing a tool for directing gut-specific expression and genetic manipulations. NGRS was also found not to require Nkx3.2 for its activity. Finally, NGRS is demonstrated to have the potential to mark abnormal spleen development, in a previously unreported splenic mutant: the Rwhs mutant. Potential uses for NGRS are explored. An approach was taken to mark and follow spleen development, using NGRS-LacZ in an organ culture system. Data generated from these experiments shed some light on how the E11.5 spleen develops, providing evidence for migration of splenic precursors along the stomach, and suggesting that an inhibitory “anchor” effect is normally exerted by the posterior spleno-pancreatic mesenchyme, disruption of which permits precocious spleen development. Finally, an analysis of the role of Wnt signalling in development of the spleno-pancreatic region is presented. Wnt signalling is active in the developing spleen at E11.5, E12.5 and E14.5. A number of Wnt and Frz genes are expressed in the E14.5 spleen.
2
Almeida, Mônica de. "Réinventions du "Spleen de Paris" : traduire Baudelaire". Paris 8, 2006. http://www.theses.fr/2006PA082698.
Testo completoAbstract (sommario):
Le poème en prose est considéré comme une notion problématique dans les études sur le langage et malgré plusieurs tentatives pour définir cette écriture, elle représente encore une exception dans l’univers littéraire. Dans Le Spleen de Paris, Baudelaire fait allusion à ses poèmes comme des « accidents », comme un ouvrage « qui n’a ni queue ni tête, puisque tout, au contraire, y est à la fois tête et queue, alternativement et réciproquement ». L’objectif de ce travail est de discuter des aspects concernant le mode de fonctionnement et la singularité des Petits poèmes en prose de Baudelaire, à partir des traductions de ce recueil, surtout en langue portugaise (Brésil), mais aussi en prenant en compte des fragments des versions en anglais et en espagnol. Ces réinventions constituent des projets littéraires autonomes, orientés par des conceptions de langage distincts et en ce sens, chaque réécriture fournit des éléments pour réfléchir sur les différentes stratégies et théories de la traductionThe prose poem is considered as a problematic notion in language studies and despite many attempts to find a definition to this writing, it still remains an irregularity in the universe of literature. In Paris Spleen Baudelaire refers to his poems as an “accident”, as a work “that has neither head nor tail, since everything, on the contrary, is both head and tail, alternatively and reciprocally”. The goal of this research is to discuss some aspects concerning the principles of composition and the peculiarity of the Small Prose Poems, based on the translations of this work in Portuguese (Brazil), and also taking into account fragments of versions in English and in Spanish. These reinventions frame independent literary projects and they are oriented by distinct conceptions of language. In this way, each rewriting presents elements to think on different strategies and theories of Translation
3
McAdoo, Stephen. "The role of spleen tyrosine kinase in glomerulonephritis". Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/40926.
Testo completoAbstract (sommario):
Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase that has an important role in immunoreceptor signalling, including for the B cell receptor and activatory Fc receptors. SYK inhibition has shown efficacy in animal models of non-renal autoimmune disease. The role of SYK in experimental and clinical renal disease, however, is not well defined. I have studied the effects of SYK inhibition using a specific small molecule inhibitor (R788; fostamatinib) in two distinct experimental models of glomerulonephritis in the rat. In experimental autoimmune glomerulonephritis (EAG; a model of anti-glomerular basement membrane disease), I have shown that SYK inhibition with fostamatinib both prevents and treats established disease. Significant attenuation of humoral autoimmune responses was observed, and ELISpot and flow cytometric analysis suggests that this was due to a direct inhibitory effect on B cell activity, rather than overall B cell survival. In addition, SYK inhibition appeared to inhibit antibody-dependent, Fc receptor-mediated pro-inflammatory responses, particularly within glomerular macrophages, in EAG. In experimental autoimmune vasculitis (EAV; a model of anti-neutrophil cytoplasm antibody [ANCA] associated vasculitis), SYK inhibition was an effective treatment for life-threatening manifestations of disease, including glomerulonephritis and lung haemorrhage. I have also examined the pattern of SYK expression by immunohistochemistry in clinical renal biopsy specimens from approximately 100 patients with a spectrum of glomerular pathologies. I found that SYK is expressed and activated in proliferative types of glomerulonephritis, and that expression levels correlate with disease activity in anti-GBM disease, ANCA-associated vasculitis, lupus nephritis and IgA nephropathy. These data suggest that SYK is important in the pathogenesis of proliferative glomerulonephritis. SYK inhibition is an effective treatment strategy for the organ-threatening manifestations of disease in two experimental models, and SYK inhibition therefore warrants further investigation in human renal disease.
4
Edmond, A. M. "The spleen in sickle cell disease in childhood". Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598759.
Testo completo
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Sasaki, Minoru. "Contextualisation poético-politique du spleen moderne chez Baudelaire". 名古屋大学教養教育院, 2012. http://hdl.handle.net/2237/21051.
Testo completo
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Paula, Daniel Rameh de. "Le spleen de Paris : uma estética do confronto". reponame:Repositório Institucional da UnB, 2017. http://repositorio.unb.br/handle/10482/31318.
Testo completoAbstract (sommario):
Dissertação (mestrado)—Universidade de Brasília, Instituto de Letras, Departamento de Teoria Literária e Literaturas, Programa de Pós-Graduação em Literatura, 2017.Submitted by Raquel Almeida (raquel.df13@gmail.com) on 2018-02-22T19:08:26Z No. of bitstreams: 1 2017_DanielRamehdePaula.pdf: 1100981 bytes, checksum: d7c0958ce3e774e645cdc02a435bbc9f (MD5)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
O objetivo deste trabalho é refletir acerca do tema do confronto em Le Spleen de Paris – Petits poèmes en prose, de Charles Baudelaire, um dos inauguradores da lírica moderna. Serão abordados, em especial, três aspectos da ideia de confronto na obra referida: o confronto estético; o confronto com o outro; e o confronto consigo mesmo. Considerando-se que o spleen figura em um dos títulos imaginados por Baudelaire para nomear a coletânea de poemas em questão, é de se supor que esse sentimento contribua para a tendência do sujeito poético da obra a estabelecer relações marcadamente conflituosas. Assim, em síntese, o problema sobre o qual se intenciona debruçar-se neste trabalho pode ser proposto do seguinte modo: em que medida a disseminação do tema do confronto em Le Spleen de Paris pode ser relacionada ao sentimento do spleen? Ao longo desse percurso, tendo como principais referenciais teóricos as teses de Antoine Compagnon, Hugo Friedrich e Walter Benjamin, será necessário evocar características fulcrais da modernidade e refletir acerca da noção de spleen, conceitos que se relacionam entre si e também com o modo como o confronto se espalha na obra em questão.
Ce travail a pour but de réfléchir à propos du sujet de l’affrontement dans Le Spleen de Paris – Petits poèmes en prose, de Charles Baudelaire, l’un des inventeurs de la poésie moderne. De manière plus spécifique, trois aspects de l’idée d’affrontement seront analysés dans l’oeuvre mentionnée: l’affrontement esthétique; l’affrontement à l’autre; l’affrontement à soi-même. En considérant que le spleen figure sur l’un des titres imaginés par Baudelaire pour nommer son recueil de poèmes, on peut supposer que ce sentiment participe à la tendance du je poétique à établir des relations assez turbulentes. En somme, la problématique sur laquelle nous nous proposons de nous concentrer peut être formulée de la manière suivante: dans quelle mesure la dissémination de l’affrontement dans Le Spleen de Paris se lie-t-elle au sentiment du spleen? Au long du parcours, en prenant pour référence théorique surtout les idées d’Antoine Compagnon, Hugo Friedrich et Walter Benjamin, il sera nécessaire d’évoquer des caractéristiques centrales de la modernité et réfléchir à propos de la notion de spleen - des concepts qui se lient l’un à l’autre et aussi à la manière dont l’affrontement se répand dans l’oeuvre ci-analysée.
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Desanti, Guillaume. "Hematopoietic and structuring process of the fetal spleen". Paris 7, 2007. http://www.theses.fr/2007PA077093.
Testo completoAbstract (sommario):
Chez la souris, l'ébauche de la rate foetale apparaît à jour embryonnaire 12,5 et contient des progéniteurs myéloides et érythrocytaires. À ce stade, la circulation sanguine est déjà établie et participe à la diversification du « pool » de cellules hématopoïétiques. Au cours de la vie foetale, les cellules hématopoïétiques de la rate prolifèrent et se différencient. Jusqu'à présent, le développement de la rate, son rôle sur la constitution du système hématopoïétique et les mécanismes qui participent à sa structuration ont été peu étudiés. Au cours de ma thèse, j'ai isolé les cellules stromales CD34 et CD34+ de la rate foetale qui pourraient contribuer activement au recrutement des cellules hématopoiétiques. J'ai étudié le contenu hématopoiétique de la rate foetale à différents stades de développement. J'ai caractérisé par des essais in vitro et in vivo une population CD4'nt qui se compose de progéniteurs T, NK, B et myéloides. Ces progéniteurs se différencieraient in situ et participeraient à l'activité hématopoiétique de la rate foetale. J'ai séparé ces progéniteurs en fonction de leur expression du récepteur Flt3 et du transgène RAG2-GFP et j'ai démontré que certains d'entre eux sont capables de se différencier en cellules inductrices des tissus lymphoïdes (ITL). Les ITL jouent un rôle majeur dans la génération des organes lymphoïdes. Afin d'évaluer la fonction des ITL dans la rate foetale, j'ai étudié leur positionnement et montré leur regroupement autour des vaisseaux sanguins. Grâce à un modèle de greffes spléniques, j'ai mis en évidence que les cellules B et les ITL occupent les mêmes régions. Ces résultats suggèrent que la position des futurs follicules lymphoïdes spléniques sont pré-établis par la régionalisation des ITL dans la rate foetale. Afin de déterminer les propriétés hématopoïétiques de l'environnement de la rate foetale, j'ai participé à l'établissement de 10 lignées de cellules stromales de rate foetales et étudié leurs capacités à soutenir la différenciation lymphoïde et myéloïde. Toutes ces lignées soutiennent l'engagement et la différentiation myéloïdes mais n'ont pas la même capacité à soutenir le développement lymphoïde. Cette diversité serait caractéristique de différentes niches de cellules stromales qui composent la rate foetale. Ces niches représenteraient des structures précoces des pulpes rouge et blancheMouse splenic anlagen appears at embryonic day 12. 5 (E12. 5) and contains erythroid and myeloid progenitors. At this stage, blood circulation is established and contributes to the hematopoietic pool diversification. During fetal life, the hematopoietic cells of the spleen proliferate and differentiate. Few studies have described the development of the spleen, the mechanisms that mediate the apparition of its structure and its role in the hematopoietic System constitution. During my thesis, I have isolated the fetal spleen CD34" and CD34+ stromal cell subsets that could actively contribute to the recruitment of hematopoietic cells. I have studied the fetal spleen hematopoietic content at different stages of development. I have characterized by in vitro and in vivo assays a CD4'm population that is composed of T, NK, B and myeloid progenitors. These progenitors could differentiate in situ and participate to the hematopoietic activity of the fetal spleen. I have further isolated these progenitors by considering their expression of Flt3 and RAG2-GFP transgene and demonstrated that some are able to give rise to the lymphoid tissue inducer (LTi) cells. These LTi cells play a major role in the lymphoid organ generation. To evaluate the LTi cell function in the fetal spleen, I have assessed their localization and shown their gathering around the blood vessels. Using spleen graft strategy, I have shown that LTi cells co-localize with B lymphocytes. These results suggest that the position of the future splenic lymphoid follicles is pre-established by LTi cells regionalization in the fetal spleen. To study the hematopoietic capacities of the fetal spleen environment, I have participated to the establishment of ten different fetal spleen stromal cell lines (FeSS) and determine their capacities to support the myeloid and lymphoid differentiation. All the FeSS promote the myeloid commitment and differentiation despite their heterogeneous ability to support the lymphoid development. This diversity could be related to the different niches of stromal cells that compose the fetal spleen. These different niches could be representative of the early red or white pulp structures
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Ouakaoui, Malek. "Esthétique du spleen dans le cinéma de l'immigration". Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAL026.
Testo completoAbstract (sommario):
Plus que jamais l’immigration est un sujet d’actualité. Elle fait systématiquement l’objet des campagnes électorales des pays d’accueil et révèle en filigrane un malaise grandissant dans les pays de départ. Ce malaise qui est surtout apparu après la décolonisation témoigne de la difficulté pour la plupart des pays du Sud d’accéder à une réelle souveraineté. La jeunesse de ces pays-là ressent alors un sentiment de déception et de mélancolie comparable au spleen vécu par les Romantiques français dans la période postrévolutionnaire. Le voyage vers un ailleurs fantasmé devient alors un moyen de dépassement et parfois même de survie. Mais tandis qu’au XIXe siècle, c’était l’Orient qui paraissait fascinant, notamment en littérature dite orientaliste, aujourd’hui la tendance semble s’être inversée pour donner lieu à un occidentalisme cinématographique.L’immigration suppose un départ : l’émigration ; une installation : l’immigration à proprement parlé ; et parfois même un retour : la « remigration ». Chacun de ces aspect comporte des problématiques particulières sous-jacentes et pas nécessairement en rapport les unes avec les autres. Elles sont largement traitées en études sociologiques, politiques ou même économiques. Mais ces études n’ont pas vocation à nous introduire dans la pensée intérieure de ceux qui vivent les situations. Car l’Histoire à elle seule ne suffit pas à rendre compte des événements, il lui faut aussi les mémoires, et il y a souvent une différence importante entre ceux qui racontent cette Histoire – les migrations en sont un thème majeur – et ceux qui la vivent. Le cinéma, comme la littérature ont cette spécificité de faire ressentir au lecteur ou au spectateur des situations, des sentiments, des émotions. À travers une expérience esthétique, nous sommes plus à même de comprendre les problèmes, et à défaut de pouvoir les résoudre, d’en avoir au moins conscience, comme en psychanalyseToday, more than ever, immigration is one of the most debated issues. It is systematically the subject of the electoral campaigns of the host countries and reveals a growing unease in the countries of origin of the immigrants. This uneasiness, which has especially emerged after decolonization, shows how difficult it is for most countries of the South to gain real sovereignty. The youth of these countries then feel a sense of disappointment and melancholy comparable to the spleen experienced by the French Romantics in the post-revolutionary period. The journey to a fantasy elsewhere then becomes a way both to escape and survive this world. In the nineteenth century, it was the Orient that seemed fascinating, especially in the so-called orientalist literature. Today, however, the trend seems to have reversed to give rise to cinematographic Occidentalism.Immigration presupposes a departure: emigration, settling or settlement: immigration proper; and sometimes even a return: "remigration". Each of these aspects has particular underlying issues and are not necessarily related to each other. They are widely investigated in sociological, political or even economic studies. But these studies are not intended to introduce us to the inner thinking of those who live these situations. Because History alone is not enough to account for events, it also needs memories, and there is often a significant difference between those who tell this History - migration is a major theme - and those who live it. Cinema and literature have this specificity of making the reader or the spectator feel the situations, the feelings and the emotions. Through an aesthetic experience, we are much abler to understand the problems. Though we may fail to fully solve these problems, we can at least be aware of them, as is the case in psychoanalysis
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Brownback, Paul (Paul Eldon). "Effects of Gold Sodium Thiomalate on Murine Spleen Cells". Thesis, North Texas State University, 1986. https://digital.library.unt.edu/ark:/67531/metadc500436/.
Testo completoAbstract (sommario):
The effects of gold sodium thiomalate (GST) on murine spleen cells were investigated using in vitro mitogen blastogenesis techniques. Addition of GST to intact spleen cells resulted in a decreased blastogenic response to the T cell mitogen, concanavalin A (Con A). Thymidine uptake of spleen cells depleted of macrophages and cultured with Con A and GST demonstrated biphasic effects. At 2.5 pg Con A/ml, blastogenesis of macrophage depleted spleen cells was inhibited to a lesser degree than intact spleen cells; whereas, at 0.5 pg Con A/ml, the macrophage depleted spleen cells were inhibited to a greater degree than the intact spleen cells. Addition of GST at intervals ranging from 0 to 48 hours indicated that inhibition occurred within 36 hours following mitogen stimulation. These results suggest that GST inhibits early events of lymphocyte activation by direct interaction with lymphocytes.
10
You, Yuying. "Cross-talk between marginal zone B cells and marginal zone macrophages". Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2010. https://www.mhsl.uab.edu/dt/2010p/you.pdf.
Testo completo
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Bumeister, L. V., e E. O. Galeta. "Determining of patterns of distribution and concentration of white pulp in various parts of the human spleen using scanning electron microscopy". Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/58519.
Testo completoAbstract (sommario):
For the immune function of the spleen is responsible white pulp, which is only 15 - 20% of the mass of the organ. Distribution of white pulp in the spleen is uneven. We can assume that transplantation of splenic tissue, which contains more white pulp, will facilitate faster and more efficient recovery of immune function.
12
Пак, Василь Якович, Василий Яковлевич Пак, Vasyl Yakovych Pak, В. М. Попадинець e В. М. Чоповський. "Оптимізація органозберігаючих операцій на селезінці з урахуванням її морфологічних особливостей". Thesis, Вид-во СумДУ, 2007. http://essuir.sumdu.edu.ua/handle/123456789/5094.
Testo completo
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Пак, Василь Якович, Василий Яковлевич Пак, Vasyl Yakovych Pak, Ольга Іванівна Матлай, Ольга Ивановна Матлай e Olha Ivanivna Matlai. "Оптимізація лікувальної тактики при травмі селезінки". Thesis, Вид-во СумДУ, 2006. http://essuir.sumdu.edu.ua/handle/123456789/7710.
Testo completo
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Луканьова, С. М. "До питання про механізм виникнення акцісорних селезінок". Thesis, Видавництво СумДУ, 2008. http://essuir.sumdu.edu.ua/handle/123456789/11387.
Testo completo
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Кононенко, Микола Григорович, Николай Григорьевич Кононенко, Mykola Hryhorovych Kononenko e А. В. Гоман. "Ошибки при диагностике травматических разрывов селезенки". Thesis, Изд-во СумГУ, 2005. http://essuir.sumdu.edu.ua/handle/123456789/7315.
Testo completo
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Кононенко, Микола Григорович, Николай Григорьевич Кононенко, Mykola Hryhorovych Kononenko e А. В. Гоман. "Клиническая симптоматика двухмоментных разрывов селезенки". Thesis, Изд-во СумГУ, 2005. http://essuir.sumdu.edu.ua/handle/123456789/7313.
Testo completo
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Seifert, Hilary. "The Inflammatory Response Initiated by the Spleen to Ischemic Stroke". Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4767.
Testo completoAbstract (sommario):
The peripheral immune system plays a role in delayed neural injury after stroke. This response originates from the spleen as splenectomy prior to middle cerebral artery occlusion (MCAO) in rats significantly reduces infarct volume in the brain. This research is based on the hypothesis that inhibiting the splenic response will reduce neurodegeneration after stroke. Studies in animals have implicated lymphocytes as the immune cell type that is detrimental following MCAO. Interferon gamma (IFNγ) has been identified as a pro-inflammatory cytokine that is also detrimental following stroke. IFNγ is important because it activates microglia and macrophages in a pro-inflammatory nature that increases neural injury following stroke. Therefore IFNγ was examined in the brain and the spleen following MCAO. IFNγ protein was elevated at 24 h in the spleen and at 72 h in the brain post MCAO. Microglia/macrophages become maximally activated at 72 h in the brain after MCAO. Splenectomy decreases the levels of IFNγ in the brain following MCAO. Systemic administration of IFNγ reversed the protective effects of splenectomy.
The cellular response to MCAO was examined next because of the difference in time between the spike in IFNγ in the spleen and the delayed increase in the brain. The cellular response from the spleen was studied by labeling splenocytes five days prior to MCAO with a fluorescein dye. Tissues were examined 48 and 96 h post MCAO or sham MCAO for fluorescence. These cells were released from the spleen into circulation at 48 h post MCAO and migrated to the brain where the cells produced IFNγ at 96 h post MCAO.
IFNγ appears to play a role in the splenic response to stroke. One protein that is up regulated by cells that have been activated by IFNγ, interferon-inducible protein 10 (IP-10) is part of the inflammatory cycle driven by IFNγ. IP-10 recruits more IFNγ producing T helper (Th) cells to the site of injury. IP-10 has the unique ability to attract Th1 cells, the pro-inflammatory Th cells, and inhibit Th2 cells, the anti-inflammatory Th cells. This leads to more IFNγ production as IFNγ is the signature cytokine of a Th1 response. IP-10 is significantly increased in the brain at 72 h post MCAO, similar to IFNγ expression. In the spleen IP-10 increased at 24 h and remained elevated out to 96 h following MCAO. IFNγ signaling was inhibited by utilizing an IFNγ neutralizing antibody administered beginning 24 h post MCAO. The IFNγ antibody treated group had decreased infarct volumes, IP-10 levels in the brain, and appeared to have decreased T cells in the ipsilateral hemisphere at 96 h post MCAO.
Following ischemic stroke splenocytes are released into circulation and migrate to the brain. They release IFNγ to activate microglia/macrophages in a proinflammatory phenotype causing an increase in IP-10 levels. IP-10 then potentiates the Th1 driven inflammation which inhibits the Th2 response. The elevated levels of IFNγ increase neural injury following MCAO. Blocking IFNγ selectively blocks the inflammatory facet of the immune response to reduce stroke induced neurodegeneration. This leaves the other immune responses intact and able to contribute to tissue repair, regeneration, and able to respond to infections. Selectively inhibiting IFNγ signaling is a promising stroke therapeutic.
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Vines, David John. "The purification and characterisation of tripeptidyl peptidase-1 from spleen". Thesis, St George's, University of London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265248.
Testo completo
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Watkins, Alan James. "Molecular characterization of splenic marginal zone lymphoma". Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609484.
Testo completo
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Wardemann, Hedda. "B-cell development and function in the absence of the spleen". [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963774301.
Testo completo
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Hicks, Julie Ann. "MicroRNAs in the spleen and liver of the developing chick embryo". NCSU, 2007. http://www.lib.ncsu.edu/theses/available/etd-03252007-215944/.
Testo completoAbstract (sommario):
MicroRNAs are small (~19-24nt) non-coding RNAs that are involved in the regulation of gene expression. They are mainly expressed in development and many are expressed in a temporal as well as, a spatial manner. It is thought they may regulate up to 30% of all genes. Pyrosequencing using 454 Life Science technology is becoming the preferred method for microRNA profiling ad sequencing compared to the previous method of cloning and using traditional sequencing techniques. Use of 454 Life Sciences technology allows for a greater coverage of microRNAs and increases the chances of sequence low abundance microRNAs. In the current project we created four small RNA libraries from embryonic chick tissues, the spleen and liver at developmental time points E15 and E20. These libraries were then sequenced using 454 Life Sciences pyrosequencing. A total of 92,919 sequence reads were obtained, representing a total of 52,001 known chicken microRNAs. Of these 92,919 reads, 52,001 represented miRNAs matching the miRBase G. gallus database, and 3,472 were not found in the G. gallus database but were homologues of miRBase miRNAs from other species. Of these homologous reads 391 represented potential novel miRNAs. Other small RNAs, such as tRNA and rRNA, represented 24,672 of the reads, and 12,383 reads represented other types of sequences, such as degraded mRNA. More than one hundred different known miRNAs were identified in this study, and many were expressed in all four libraries. Common miRNAs that yielded multiple reads from all four libraries included miR-125b and miR-21, which are involved in general processes of cellular proliferation. Overall, the spleen libraries had a larger array of miRNAs than the liver libraries. Much of spleen development occurs during the later stages of embryonic development, so we can reasonably expect that many gene expression changes occur during these stages. As a result of this study, we identified nine potential novel chicken miRNAs. These novel miRNAs appear to be tissue-specific. The potential novel miRNAs appeared to be expressed at lower levels than some of the known miRNAs, which could indicate that most of the highly-expressed chicken miRNAs have already been identified, whereas, for the most part, the miRNAs expressed at low levels remain to be discovered.
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Приходько, Ольга Олексіївна, Ольга Алексеевна Приходько, Olha Oleksiivna Prykhodko e M. Salifu. "Morphological changes in the spleen of a rat caused by dehydration". Thesis, Сумський державний університет, 2014. http://essuir.sumdu.edu.ua/handle/123456789/35796.
Testo completoAbstract (sommario):
The spleen of the rat is invariably inseparable with that of the human. The study investigates the various morphological changes that will occur in the spleen of the rat when it is subjected to dehydration for a variable period. The study was conducted and its objectives are stated below;
To understand the basic anatomy of the spleen of the rat and its relationship with that of human.
When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35796
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Alshabanah, Othman A. "Polyamine and acetylpolyamine levels during phenylhydrazine-induced erythropoiesis in mouse spleen". Scholarly Commons, 1988. https://scholarlycommons.pacific.edu/uop_etds/3406.
Testo completoAbstract (sommario):
The phenylhydrazine-induced erythropoietic mouse spleen is used as a model system to demonstrate the relationship between tissue growth and polyamine metabolism. Phenylhydrazine produced significant changes in spleen weights, hematocrits and reticulocyte counts in Swiss-Webster mice. The average spleen weight went up from a control of 155 mg to 875 mg at 96 hours after phenylhydrazine administration, while a 49% reduction in the value of hematocrit was observed at 72 hours. Reticulocyte counts in peripheral blood went from 0.8 to 58% at 168 hours after treatment with phenylhydrazine. Phenylhydrazine at a dose of 40 mg/kg produced significant increases in the levels of putrescine, spermidine and spermine with maxima reached within 72 hours. The levels of N$\sp1$-acetylspermidine reached a maximum of 2.7-fold compared to control at 96 hours. When the dose of phenylhydrazine was increased to 120 mg/kg, peak levels of acetylated polyamines were reached within 96 hours at which time N$\sp1$-acetylspermidine levels rose to 2.9-fold and N$\sp8$-acetylspermidine levels went from not detectable to detectable levels. the levels of putrescine, spermidine and spermine reached maxima at 96 hours of 289, 1248 and 934 nmoles/g, respectively. DL-$\alpha$-difluoromethylornithine hydrochloride monohydrate (DFMO) inhibited the increases in putrescine levels and potentiated the increases in spermine levels induced by phenylhydrazine, while 7-(N-(3-aminopropyl)amino) heptan-2-one.2HCl (APAH) induced significant increases in the levels of N$\sp8$-acetylspermidine. APAH potentiated the increases in spleen weights induced by phenylhydrazine.
24
Lodin, Angelica. "Initiation of spleen contraction resulting in natural blood boosting in humans". Doctoral thesis, Mittuniversitetet, Avdelningen för hälsovetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-25518.
Testo completoAbstract (sommario):
The spleen has been shown to contract in apneic situations in humans as well as in other diving mammals, expelling its stored red blood cell content into circulation. This natural blood boosting may increase the circulating hemoglobin concentration (Hb) by up to 10%, which would enhance the oxygen carrying capacity and likely increase performance. However, the triggers of this response in humans have not been fully clarified. Study I was therefore focused on the effect of hypoxia as a trigger of spleen contraction. It was found that 20 min of normobaric hypoxic breathing evoked a substantial reduction in spleen volume showing that hypoxia is an important trigger for spleen contraction. Knowing the role of hypoxia, Study II compared two different hypoxic situations – a 2 min apnea and 20 min normobaric hypoxic breathing – which resulted in the same level of arterial hemoglobin desaturation. Apnea evoked a twice as great spleen volume reduction, implying that variables other than hypoxia were likely involved in triggering spleen contraction. This may be hypercapnia which is present during apnea but not during normobaric hypoxic breathing. Study III therefore investigated the effects of breathing gas mixtures containing different proportions of CO2 prior to maximal apneas. Pre-breathing mixtures with higher percentages of CO2 resulted in greater spleen contraction, thus demonstrating hypercapnia's likely role as a trigger in addition to hypoxia. Study IV explored whether an all-or-nothing threshold stimulus for triggering spleen contraction existed, or if contraction was graded in relation to the magnitude of triggering stimuli. Exercise was therefore performed in an already hypoxic state during normobaria. Rest in hypoxia produced a moderate spleen volume reduction, with an enhanced spleen contraction resulting after hypoxic exercise, with a concomitant increase in Hb. This implies that spleen contraction is a graded response related to the magnitude of the stimuli. This could be beneficial in environments with varying oxygen content or work loads. Study V examined the possibility that spleen contraction is part of the acclimatization to altitude, during an expedition to summit Mt Everest. The long-term high altitude exposure, combined with physical work on the mountain, had no effects on resting spleen volume but resulted in a stronger spleen contraction, when provoked by apnea or exercise. This indicates that acclimatization to altitude may enhance the contractile capacity of the spleen, which may be beneficial for the climber. From these studies I concluded that hypoxia is an important trigger for spleen contraction but that hypercapnia also contributes in apneic situations. The spleen contraction likely provides a graded expulsion of erythrocytes in response to these stimuli, causing a temporary increase in gas storage capacity that may facilitate activities such as freediving and climbing. The storage of erythrocytes during rest serves to reduce blood viscosity, which would also be beneficial for the climber or diver. The human spleen contraction appears to become stronger with acclimatization, with beneficial effects at altitude. Such an upgraded response could be beneficial both in sports and diseases involving hypoxia.
25
Wild, Corinne. "Involvement of the ephrin-B2 ligand in spleen development and function /". [S.l.] : [s.n.], 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000277025.
Testo completo
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Murtaza, Ghulam, Muhammad Khalid, Majd Kanaa e Jack Stanley Goldstein. "Pancreatic Pseudocyst Complicated by Hemorrhage into the Peritoneal Cavity and Spleen". Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/214.
Testo completoAbstract (sommario):
Pancreatic pseudocysts are a complication of acute or chronic pancreatitis or result from blunt trauma to the pancreas. It is a localized fluid collection around the pancreas surrounded by a wall of fibrous tissue or inflammation. We present a case of a 56-years old male who presented with abdominal pain and sepsis due to spontaneous rupture of the hemorrhagic pancreatic cyst into the peritoneal cavity and spleen.
56-years old male with medical history of gastroesophageal reflux disease presented with epigastric and left upper quadrant intermittent abdominal pain. Patient denied fever, chills, nausea, and vomiting, family history of pancreatic cancer, anticoagulation use, gallstones, alcohol intake and prior history of pancreatitis. On admission, vitals were B.P 137/82, Pulse 102, RR 16, O2 saturation 92% on room air. Physical exam was significant for left upper quadrant and epigastric tenderness. Labs were lipase 230, amylase 112, lactate 0.7, wbc 7.0, hemoglobin of 15.2 and triglyceride levels were 189mg/dl. Computed tomography (CT) abdomen showed acute pancreatitis and a 4.5 x 4.4 x 2.8 cm cystic lesion between the tail of the pancreas and splenic hilum. Ultrasound of the abdomen showed normal gallbladder with no evidence of biliary ductal dilatation. Magnetic resonance cholangiopancreatography (MRCP) abdomen showed 4.3 cm walled off, possibly hemorrhagic fluid collection, between the spleen and the pancreas. Patient had normal CA-19 level. Patient was evaluated by general surgery who recommended conservative management with repeat CT in 6 weeks with possible pancreatectomy and removal of mass if not resolved. Patient was readmitted 3 days after discharge with worsening abdominal pain and sepsis. Physical exam was significant for epigastric and left upper quadrant tenderness without guarding or rebound. Labs showed lactate 3.4, wbc 11.3, hgb 12.1 and lipase 600. Repeat CT scan showed rupture of the hemorrhagic pancreatic cyst with possible extravasation and enlarged spleen with perisplenic and subcapsular blood represent splenic infarcts. Repeat MRCP confirmed CT findings. Patient was planned for splenectomy and distal pancreatectomy.
Most pancreatic pseudocysts resolve spontaneously [1]. Bleeding, infection, rupture, pseudoaneurysm, splenic and biliary complications and portal hypertension are some of the complications if left untreated. Hemorrhage into the pancreatic pseudocyst is a rare complication with a reported incidence of 10-30% with a high mortality rate (40%). Bleeding most commonly involves splenic artery (30–50%), followed by the gastroduodenal artery (17%) and pancreaticoduodenal arteries (11%) [2]. Diagnosis is made by ultrasound, CT scan, MRI or ERCP. Treatment involves either percutaneous drainage, or endoscopic or surgical approach. Spontaneous rupture into the peritoneal cavity is a rare life threatening complication requiring immediate surgical intervention. This case highlights the early recognition of complications of ruptured pancreatic pseudocyst to prevent fatal consequences.
References:
1: Lerch MM, Stier A, Wahnschaffe U, Mayerle J: Pancreatic Pseudocysts: Observation, Endoscopic Drainage, or Resection. Deutsches Ärzteblatt International 2009, 106:614-621.10.3238/arztebl.2009.0614.
2: Novacic K1, Vidjak V, Suknaic S, Skopljanac A: Embolization of a large pancreatic pseudoaneurysm converted from pseudocyst (hemorrhagic pseudocyst). JOP 2008, 9:317-21. joplink.net/prev/200805/13.html
27
Richardson, Matt X. "Hematological changes arising from spleen contraction during apnea and altitude in humans". Doctoral thesis, Mittuniversitetet, Institutionen för naturvetenskap, teknik och matematik, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-7786.
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Sultanian, Richard A. "Characterization of the mechanism of ANF-induced fluid extravasation from the spleen". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0012/MQ59884.pdf.
Testo completo
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IWATA, HISASHI, MASARU OHASHI e HIROSHI SHIGENO. "Glycosaminoglycan in Liver and Spleen of Casein-Induced Experimental Amyloidosis of Mice". Nagoya University School of Medicine, 1985. http://hdl.handle.net/2237/17484.
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30
KONDO, TATSUHEI, HIDEO KAMEI, FUMIHIRO KOBAYASHI, TAKAO YUKAWA, KEISUKE TERABE, YASUHISA HASEGAWA, YOHICHI ITOH e TAKASHI KOJIMA. "Colony-Stimulating Activity in Cultures of Human Spleen and Bone Marrow Cells". Nagoya University School of Medicine, 1986. http://hdl.handle.net/2237/17486.
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31
Schweig, Jonas Elias. "The contribution of spleen tyrosine kinase to the pathobiology of Alzheimer's disease". Thesis, Open University, 2018. http://oro.open.ac.uk/57285/.
Testo completoAbstract (sommario):
Alzheimer's disease (AD) is a neurodegenerative disease that accounts for most cases of dementia. The pathological hallmarks of AD include extracellular A-beta plaques, intracellular tau accumulations or neurofibrillary tangles, as well as neuroinflammation. As of 2018, there exists no disease modifying treatment for AD and the cause of sporadic AD remains elusive. We investigated the contribution of the spleen tyrosine kinase (SYK) in AD pathobiology. Syk is wellknown for its involvement in B-cell receptor (BCR) signaling but our previous data have demonstrated that SYK is also involved in tau yperphosphorylation and A-beta production, therefore suggesting that SYK could contribute to the formation of AD pathological lesions. The goals of our present studies were to determine whether SYK activation occurs in the brain of mouse models of AD and investigate whether the levels of SYK activation vary with the amount of AD pathological lesions. In addition, we aimed to examine the role of SYK in the autophagic degradation of tau via the mammalian target of rapamycin (mTOR) pathway in vitro and in vivo. We investigated SYK activation in different age-groups of A-beta and tau overexpressing mice, as well as human AD specimens. We characterized the activation of SYK in relation to AD pathological lesions including amyloid plaques, activated microglia and astroglia, as well as hyperphosphorylated tau. In addition, our mechanistic in vitro experiments delineated SYK as a regulator of autophagic tau degradation via the mTOR pathway. These data were confirmed in an in vivo study, assessing the effects of a 12-week chronic SYK inhibition on tau burden, neurodegeneration, behavior, and neuroinflammation in a mouse model with established tauopathy. Identifying new targets like SYK that act downstream of A-beta and tau and in turn exacerbate these known pathologies, is crucial to find a treatment for AD.
32
Приходько, Ольга Олексіївна, Ольга Алексеевна Приходько, Olha Oleksiivna Prykhodko, E. Kubikova, Валентина Іванівна Бумейстер, Валентина Ивановна Бумейстер, Valentyna Ivanivna Bumeister e Bennibor Blessed Onisokien. "Determination of biomarkers p53 and Ki- 67 in rats` spleen while dehydration". Thesis, Сумський державний університет, 2016. http://essuir.sumdu.edu.ua/handle/123456789/45061.
Testo completoAbstract (sommario):
The spleen is one of the largest lymphoid organs, it is an organ of the circulatory system. The basic function of rats` spleen is similar to that of a man, which is to clean the blood from damaged old particles of the body itself .The rat`s spleen is equipped with the red and white pulp with a specific structure of blood circulation. Being affected by unfavourable factors, the spleen has a system of protective mechanisms, which are based on the processes of cell renewal and apoptosis.
We analyzed the localization and quantification of the expression of apoptosis markers p53 and Ki-67 proliferation of the rats` spleen during cellular dehydration.
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Hoover, David B., Megan D. Poston, Stacy D. Brown, Sarah E. Lawson, Cherie E. Bond, Anthony M. Downs, David L. Williams e Tammy R. Ozment. "Cholinergic Leukocytes in Sepsis and at the Neuroimmune Junction in the Spleen". Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etsu-works/7845.
Testo completoAbstract (sommario):
The spleen is a key participant in the pathophysiology of sepsis and inflammatory disease. Many splenocytes exhibit a cholinergic phenotype, but our knowledge regarding their cholinergic biology and how they are affected by sepsis is incomplete. We evaluated effects of acute sepsis on the spleen using the cecal ligation and puncture (CLP) model in C57BL/6 and ChATBAC-eGFP mice. Quantification of cholinergic gene expression showed that choline acetyltransferase and vesicular acetylcholine transporter (VAChT) are present and that VAChT is upregulated in sepsis, suggesting increased capacity for release of acetylcholine (ACh). High affinity choline transporter is not expressed but organic acid transporters are, providing additional mechanisms for release. Flow cytometry studies identified subpopulations of cholinergic T and B cells as well as monocytes/macrophages. Neither abundance nor GFP intensity of cholinergic T cells changed in sepsis, suggesting that ACh synthetic capacity was not altered. Spleens have low acetylcholinesterase activity, and the enzyme is localized primarily in red pulp, characteristics expected to favor cholinergic signaling. For cellular studies, ACh was quantified by mass spectroscopy using d4-ACh internal standard. Isolated splenocytes from male mice contain more ACh than females, suggesting the potential for gender-dependent differences in cholinergic immune function. Isolated splenocytes exhibit basal ACh release, which can be increased by isoproterenol (4 and 24 h) or by T cell activation with antibodies to CD3 and CD28 (24 h). Collectively, these data support the concept that sepsis enhances cholinergic function in the spleen and that release of ACh can be triggered by stimuli via different mechanisms.
34
Patterson, Kristin Diane. "Vertebrate tinman-related homeobox genes during heart and spleen development in Xenopus /". Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.
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Fusianto, Cahya Kurnia. "Detection and control of Infectious spleen and kidney necrosis virus in aquaculture". Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/26880.
Testo completoAbstract (sommario):
Infectious spleen and kidney necrosis virus (ISKNV), genus Megalocytivirus, causes disease of fish, with infection reported for more than 52 marine and freshwater species (Subramaniam et al., 2014). The objective of this thesis was to generate knowledge to inform ISKNV disease control in aquaculture. The first approach applied a broad range of diagnostic techniques to investigate an outbreak of high mortality infectious disease in farmed hybrid grouper (Epinephelus spp.) in Indonesia. An epidemiologic framework for disease investigation revealed that ISKNV was the primary aetiologic pathogen despite other potential pathogens including ectoparasites, bacteria, and viruses identified. The second study developed a hybrid capture nucleic acid enrichment technique before Illumina sequencing to generate knowledge about the diversity within the whole genome of ISKNV for 16 samples collected in Southeast Asia between 2011 to 2018. This supported differentiation of genotypes within the species ISKNV, with high genomic similarity within each genotype. Analysis of single nucleotide polymorphisms identified clusters that shared a common collection location. This approach may be valuable to understand local and transboundary spread of ISKNV. The third study evaluated disinfection protocols for ISKNV under high soiling conditions using Murray cod (Maccullochella peelii) as a sensitive bioassay for viral infectivity. The study demonstrated that ISKNV could remain infectious in aquaria without fish for at least 48h at 25°C. Practical efficacious disinfection procedures included heating (65°C for 20 min), chlorine (1000 ppm for 30 min), alteration of pH (3 or 11 for 30 min), Virkon™ 1%, and a quaternary ammonium compound (650 ppm for 10 min). This thesis provides valuable information for effective disease control in aquaculture and recommends priorities to further reduce the growing, global impacts of ISKNV.
36
Payne, Christine Jayne. "Studies of big liver and spleen disease virus of broiler breeder hens". Thesis, Payne, Christine Jayne (2001) Studies of big liver and spleen disease virus of broiler breeder hens. PhD thesis, Murdoch University, 2001. https://researchrepository.murdoch.edu.au/id/eprint/53196/.
Testo completoAbstract (sommario):
Big liver and spleen disease (BLSD) is a disease of broiler breeders first recognised in Australia in 1980. The disease occurs in sexually mature hens and manifests as decreased egg production in association with a slight increase in mortality rates in affected flocks. The predominant lesions in sick hens or dead hens are splenomegaly and hepatomegaly. Previous to the studies reported in this thesis, the cause of the disease had not been identified, although a viral agent was suspected, and agar gel immunodiffusion (AGIO) tests had detected a disease-specific antigen in liver tissue of chickens during the early stages of the disease. The objective of the research reported in this thesis was the identification and characterisation of the putative virus associated with BLSD, tentatively designated big liver and spleen disease virus (BLSV).
Utilising the disease-specific antigen present in the liver of affected hens, which was purified by affinity chromatography, an antibody-detection enzyme-linked immunosorbent assay (ELISA) was developed that enabled the detection of disease-specific antibodies in affected and recovered chickens, presumed to be antibodies against BLSV. The antibody-detection ELISA was more sensitive than the AGIO used previously, and better suited to testing large numbers of samples. This ELISA antigen also stimulated a strong antibody response when used to immunise chickens and inoculated chickens demonstrated a rapid antigen clearance following challenge with infectious BLSV. A monoclonal antibody (mAb 1H4) against the BLSD-specific antigen was produced, and this monoclonal antibody was used to develop a BLSV-antigen-detection ELISA (ACELISA), and an immunoperoxidase technique for the detection of a BLSV-specific protein in cell cultures and tissue sections of affected chickens. BLSV was successfully cultivated in an in ovo system, which provided a means to quantitate infectious virus.
These techniques were then used to study physicochemical characteristics of the virus. Chloroform or ether treatment failed to inactivate infectivity, showing that BLSV was nonenveloped. The buoyant density was estimated to be 1.2 g/ml in continuous sucrose density gradients and the BLSV particle size was estimated to be between 50 and 100 nm by membrane filtration studies.
To further characterise the virus, molecular biological tools were applied to amplify and clone cDNA representing a fragment of the viral nucleic acid, and determine the genomic sequence of this fragment. The sequence obtained was submitted to a database for comparison to other known viral genomes to identify possible familial relationships. There was 62% similarity between BLSV sequence and a region of open reading frame 1 (ORF1) of hepatitis E virus (HEV; Accession no. X98292). A possible relationship between BLSV and human enterically-transmitted HEV, a non-enveloped, single-stranded, positive-sense RNA virus, was introduced as a hypothesis based on the sequence data.
The improved techniques developed were used to study the transmission and epidemiology of the virus. BLSV transmission studies in commercial flocks and in experimental conditions supported the hypothesis that BLSV is an enterically-transmitted virus. BLSV spread readily between chickens within individual sheds, from shed to shed on affected farms, and between experimentally infected and in-contact chickens. Hens experimentally inoculated by intravenous, oral, or conjunctival routes showed serological evidence of BLSV infection, and aerosol transmission occurred over limited distances. BLSV-antigen, detected by AC-ELISA, and infectivity were demonstrated in faeces from experimentally inoculated chickens.
37
Ferrer, Almirall Mireia. "Role of the spleen in Plasmodium vivax: a reticulocyte-prone non-lethal malaria". Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/78936.
Testo completoAbstract (sommario):
“Plasmodium vivax” és el paràsit causant de malària humana amb més àmplia distribució i és responsable cada any de 100-300 milions de casos clinics, incloent algunes manifestacions severes i mort. P. vivax envaeix principalment reticulòcits I és àmpliament acceptat que els reticulòcits infectats no citoadhereixen en els capil•lars d'òrgans interns, tenint un pas obligat per la melsa. Es desconeix com P. vivax escapa del pas per la melsa, el nostre major òrgan limfoide, i evita així ser fagocitat. La nostra hipòtesi postula que aquest paràsit indueix la formació de cèl•lules de barrera a la melsa, on reticulòcits infectats citoadhereixen de manera específica per protegir-se de l’atac dels macròfags. Per avançar en aquesta hipòtesi, hem utilitzat el model murí de malària en ratolins Balb/c infectats amb una soca noletal que infecta principalment reticulòcits, P. yoelii 17X, semblant a P. vivax, i una soca letal amb tropisme per normòcits, P. yoelii 17XL, semblant a P. falciparum. Per investigar la funció i l’estructura de la melsa en la malària, així com les característiques dinàmiques dels processos impulsats pel paràsit, hem implementat la microscòpia intravital i la ressonància magnètica de la melsa del ratolí en infeccions experimentals. Notablement, hem observat major acumulació de paràsits, motilitat reduïda, pèrdua de direccionalitat, augment en el temps de residència i ressonància magnètica alterada només a la melsa dels ratolins infectats amb 17X. D'altra banda, aquestes diferències s’han associat amb la formació d'una barrera d'origen fibroblàstic induïda en la polpa vermella de les melses de ratolins infectats amb la soca no-letal, acompanyada d'evasió dels macròfags de la polpa vermella i adherència dels glòbuls vermells infectats a la barrera. A més, hem confirmat l'adhesió de reticulòcits infectats per P. vivax de pacients humans a crioseccions de melsa humana i explorat el paper de les proteïnes Vir en aquesta adhesió. Les nostres dades suggereixen que en la malària no-letal el pas per la melsa és diferent del que es coneix en altres espècies de Plasmodium i obren noves vies per a estudis funcionals i estructurals d'aquest òrgan limfoide en la malària.Plasmodium vivax is the most widely distributed human malaria parasite and responsible each year for 100-300 million clinical cases including severe disease and death. P. vivax invades predominantly, if not exclusively, reticulocytes and it is amply accepted that it does not sequester in the deep capillaries of inner organs having an obligate passage through the spleen. Questions thus remain as how P. vivax escapes spleen-clearance and establishes chronic infections. We have advanced a hypothesis postulating that this parasite induces the formation of spleen barrier cells where infected reticulocytes specifically cytoadhere protecting themselves from spleen macrophage-clearance. To advance this hypothesis, we have used the rodent malaria model of Balb/c mice infected with the reticulocyteprone non-lethal P. yoelii 17X strain, resembling P. vivax, and the normocyte-prone lethal P. yoelii 17XL strain, resembling P. falciparum. To investigate the function and structure of the spleen in malaria, as well as the dynamic characteristics of parasitedriven processes, we implemented the intravital microscopy and magnetic resonance imaging of the mouse spleen in experimental infections. Noticeably, there was higher parasite accumulation, reduced motility, loss of directionality, increased residence time and altered magnetic resonance only in the spleens of mice infected with 17X. Moreover, these differences were associated with the formation of a strain-specific induced spleen tissue barrier of fibroblastic origin, with red pulp macrophage-clearance evasion and adherence of infected red blood cells to this barrier. We further reported adhesion of P. vivax-infected reticulocytes from human patients to cryosections of human spleens and explored the role of Vir proteins in such an adhesion. Our data suggest that in reticulocyte-prone non-lethal malaria, passage through the spleen is different from what is known in other Plasmodium species and open new avenues for functional/structural studies of this lymphoid organ in malaria.
38
Anfora, Adriana Ingrid. "Grotesco e ironia em Macário de Álvares de Azevedo: transgressão, spleen e utopia". Pontifícia Universidade Católica de São Paulo, 2012. https://tede2.pucsp.br/handle/handle/14693.
Testo completoAbstract (sommario):
Made available in DSpace on 2016-04-28T19:58:45Z (GMT). No. of bitstreams: 1
Adriana Ingrid Anfora.pdf: 629267 bytes, checksum: a904037940bc92d6404af9397dd4f61e (MD5)
Previous issue date: 2012-04-17This analysis aims to study drama Macário of Álvares de Azevedo, in order to point out each of the concepts of the grotesque, irony and trangression, utopia and spleen, and see how each element composing the text structure azevediana, taking into view of the relationship of antagonistic terms that permeates the opposing aspects of reality and dream, enabling thus a macabre atmosphere, the irruption of the supernatural in terms of imbalances of the man who lives below the dilemma in moral precepts established by society in which he lives or let nature guide their principles and values. The grotesque being investigated in this dissertation in the romantic who seeks, above all, the revolto of the individual against the reality that we can live fully and for that reason, it creates a parallel world that their aspirations to take part in this process
A presente análise tem por objetivo o estudo do drama Macário de Álvares de Azevedo, com o propósito de assinalar cada um dos conceitos relativos ao grotesco, ironia, transgressão, utopia e spleen, e verificar como cada elemento compõe a estrutura textual azevediana, tendo em vista a inter-relação entre esses mesmos componentes. A base fundamental da dissertação será a relação entre termos antagônicos que permearão os aspectos contrapostos do real e do onírico, possibilitando deste modo, uma atmosfera macabra, a irrupção do sobrenatural em função dos desajustes do homem que vive o dilema em seguir preceitos moralmente instituídos pela sociedade na qual vive ou deixar-se então guiar por sua natureza, seus princípios e valores. O grotesco, que está sendo investigado nessa dissertação, é o romântico, que visa, sobretudo, à revolta do indivíduo frente à realidade, que não lhe permite viver plenamente e, por essa razão, acaba criando um mundo paralelo, para que suas aspirações tomem parte em todo esse processo
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Silva, Morgana Duarte da. "Atividade antinociceptiva e inflamatória da acupuntura no acuponto spleen 6 (SP6) em camundongos". reponame:Repositório Institucional da UFSC, 2013. https://repositorio.ufsc.br/handle/123456789/107315.
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Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-graduação em Neurociências, Florianópolis, 2013Made available in DSpace on 2013-12-05T23:47:03Z (GMT). No. of bitstreams: 1 318772.pdf: 5433742 bytes, checksum: 9427e87275ec7e918db7e135be86a81c (MD5) Previous issue date: 2013
A acupuntura é uma técnica milenar usada, entre outras aplicações, parao alívio da dor. Neste trabalho buscou-se verificar o efeito da acupunturae seus mecanismos de ação em modelos de nocicepção e inflamação emcamundongos. A acupuntura manual (AM) foi realizada no acupontoSP6 (Spleen 6) e reduziu a nocicepção aguda induzida por ácido acético(AA) e pela formalina. O melhor perfil antinociceptivo foi obtidoatravés de inserção e retenção da agulha por 10 minutos, sendo que seuefeito perdurou por 120 minutos. Verificou-se também que a integridadedas fibras aferentes primárias, em especial do tipo C, foi essencial para oefeito da AM no acuponto SP6. Além disto, foi observado que o SP6 foio acuponto que reduziu de forma mais significativa a nocicepção agudacausada pelo AA e formalina quando comparado com os acupontosST35, BL57, KI3, GB39, LR5 e um não acuponto. A estimulação doacuponto SP6 também foi efetiva em reduzir a dor neuropática,caracterizada pela hipersensibilidade mecânica (HM) e térmica (calor)induzidas pela ligadura parcial do nervo ciático. É importante salientarque a redução da HM permaneceu inicialmente por 1 hora, porém, seprolongou por 6 horas (com 5 tratamentos) e depois 60 horas (com 10tratamentos). Verificou-se que a administração prévia de antagonista dereceptores kappa () opióides, colinérgicos (muscarínico e nicotínico),dopaminérgicos (D2) e adenosinérgicos (A1 perifericamente),preveniram o efeito antinociceptivo do SP6 no modelo do AA.Observou-se também que houve maior atividade da proteína cFos emáreas do encéfalo envolvidas na dor como o locus coeruleus (LC), asubstância cinzenta periaquetal (PAG), o núcleo magno da rafe (rafe), onúcleo paraventricular do hipotálamo (PVN), o hipocampo e a amígdalacentral (Ace), após a AM. A AM no SP6 reduziu o número total deleucócitos, o número de neutrófilos, a atividade da mieloperoxidase, apermeabilidade capilar e restabeleceu os níveis de citocinasIL(interleucina)-10 na cavidade peritoneal de animais submetidos aperitonite induzida por carragenina, sendo que este efeito foi em partedependente de glicocorticóides endógenos. A estimulação do acupontoSP6 também reduziu a HM e térmica (calor) em camundongos quereceberam carragenina (3%) via intramuscular, além de restabelecer osníveis de IL-10 no músculo. Além disto, a AM no SP6 foi capaz dealterar o número de macrófagos anti-inflamatórios com fenótipo M2 emrelação aos macrófagos inflamatórios M1, sem promover aumento nonúmero total de macrófagos no músculo dos animais que receberamcarragenina. Ainda, os efeitos antinociceptivo e anti-inflamatório da AMno SP6 não foram observados em animais nocautes para a citocina IL-10. Assim, os nossos dados estendem os dados da literatura e permitemsugerir que a AM no SP6 possui efeito antinociceptivo e antiinflamatóriopronunciado, devido a liberação de IL-10.
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Di, Giorgi Vincenzo <1988>. "Lo Spleen di Palermo. Rappresentazioni e identità intorno al cibo di strada palermitano". Master's Degree Thesis, Università Ca' Foscari Venezia, 2017. http://hdl.handle.net/10579/9540.
Testo completoAbstract (sommario):
L'alimentazione è oggi al centro di discorsi che si intersecano con svariati ambiti disciplinari. Il cibo di strada, da forma di consumo relativamente legata al commercio informale e ai mercati popolari, è stato rimodellato, rivalutato e promosso fino a raggiunge vette internazionali. Lo studio condotto in questa tesi si concentra sul caso specifico dello street food palermitano, sulle sue caratteristiche identitarie e sulle rappresentazioni che ne fanno venditori, operatori turistici e media.
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Cotterell, Sarah Elizabeth Jane. "The production and recruitment of leukocytes during murine visceral leishmaniasis". Thesis, London School of Hygiene and Tropical Medicine (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321966.
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Кононенко, Микола Григорович, Николай Григорьевич Кононенко, Mykola Hryhorovych Kononenko e А. В. Гоман. "Післяопераційні ускладнення та причини смерті у хворих з закритими пошкодженнями печінки та селезінки". Thesis, Вид-во СумДУ, 2006. http://essuir.sumdu.edu.ua/handle/123456789/7649.
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Пак, Василь Якович, Василий Яковлевич Пак, Vasyl Yakovych Pak e В. А. Полторацький. "Діагностика і лікування травматичного ушкодження селезінки". Thesis, Видавництво СумДУ, 2003. http://essuir.sumdu.edu.ua/handle/123456789/9348.
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Приходько, Ольга Олексіївна, Ольга Алексеевна Приходько, Olha Oleksiivna Prykhodko e С. Я. Удовиченко. "Вплив позаклітинної дегідратації легкого ступеню на структуру селезінки". Thesis, Сумський державний університет, 2015. http://essuir.sumdu.edu.ua/handle/123456789/41754.
Testo completoAbstract (sommario):
Важко назвати інший орган, який був би так всебічно вивчений анатомічно і експериментально, про функції і значення якого для організму було б висловлено стільки припущень і теорій, але й на сьогодні селезінка наполегливо зберігає свої таємниці, не дивлячись на величезну кількість теоретичних і практичних досліджень. Природні та техногенні катаклізми (обвали в шахтах, горах), несприятливі умови жаркого клімату (при посиленій втраті води в умовах впливу високої навколишньої температури), а також хвороби, що супроводжуються рвотою та діареєю, підвищене фізичне навантаження супроводжуються зневодненням організму. Вода і солі (насамперед натрій) втрачаються спочатку з позаклітинної рідини, пізніше починають втрачатися внутрішньоклітинна рідина і калій. Проблемі зневоднення присвятили свої праці багато морфологів, проте дослідження структурних змін, які відбуваються в селезінці при дегідратації залишаються поза увагою широкого кола науковців.
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Пак, Василь Якович, Василий Яковлевич Пак, Vasyl Yakovych Pak, В. М. Чоповський e В. М. Попадинець. "Особливості оперативного ліукування травматичного пошкодження селезінки". Thesis, Вид-во СумДУ, 2007. http://essuir.sumdu.edu.ua/handle/123456789/5087.
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Гринцова, Наталія Борисівна, Наталия Борисовна Гринцова, Nataliia Borysivna Hryntsova e Р. М. Пономарчук. "Морфофункціональні перебудови селезінки за умов адаптаційно-реадаптаційних змін у кістковій системі та клітинної дегідратації організма". Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32429.
Testo completoAbstract (sommario):
Адаптація є якісно новим станом, що характеризується підвищеною опірністю організму до екстремальних впливів, в тому числі клітинної дегідратації та травмуючого агента. Природа формування адаптативних реакцій та реадаптаційних механізмів залишається невідомою. Вивчення адаптаційних можливостей кісткової тканин та особливостей її морфофізіологічних реакцій на стресові фактори залишається актуальним напрямком досліджень у сучасній морфології. Беручи до уваги, що селезінка є однією з базових контролюючих та життєрегулюючих систем, ми припустили, що специфіка її індивідуальних проявів повинна відображатися на особливостях життєвих реакцій у підтриманні гомеостазу, що у кінцевому рахунку повинно виразитися морфологічно.
При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/32429
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Шевченко, Володимир Володимирович, Владимир Владимирович Шевченко, Volodymyr Volodymyrovych Shevchenko, Володимир Миколайович Дейнека, Владимир Николаевич Дейнека, Volodymyr Mykolaiovych Deineka e О. В. Денисенко. "Залежність ефективності відновлення імунологічної функції аутоліентрансплантанту від його морфологічної структури". Thesis, Видавництво СумДУ, 2012. http://essuir.sumdu.edu.ua/handle/123456789/27335.
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Chung, Ida Ho Ting. "Evaluation of the transcriptional response of chicken spleen to highly pathogenic avian influenza (H5N1)". Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 113 p, 2009. http://proquest.umi.com/pqdweb?did=1885480871&sid=5&Fmt=2&clientId=8331&RQT=309&VName=PQD.
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Dor, Frank Johan Marinus Frederik. "Investigations relating to the induction of immunological tolerance through spleen transplantation in miniature swine". [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2006. http://hdl.handle.net/1765/10508.
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Ranasinghe, Charles Neil. "The biochemistry and physiology of a rat spleen cell derived from haemopoietic growth factor". Thesis, University of Liverpool, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317239.
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