Bibliografie tematiche / SMLC

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Letteratura scientifica selezionata sul tema "SMLC"

Autore: Grafiati
Pubblicato: 4 giugno 2021
Ultima modifica: 13 febbraio 2022

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Articoli di riviste sul tema "SMLC"

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Prieto Castillo, Carolina. "Discurso de clausura. XXV Congreso ALAPAC/ML, III Congreso SMLC Chile, XVII Jornada SMLC, Chile 2021". Revista Mexicana de Patología Clínica y Medicina de Laboratorio 67, n. 4 (2020): 173–75. http://dx.doi.org/10.35366/99462.

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Marx, M., P. Vacha, B. Riis, T. Feyerabend e E. Richter. "444First practical experience with a simulation-multileafcollimator (SMLC)". Radiotherapy and Oncology 40 (gennaio 1996): S114. http://dx.doi.org/10.1016/s0167-8140(96)80453-1.

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Kayacan, Erkan. "Sliding mode learning control of uncertain nonlinear systems with Lyapunov stability analysis". Transactions of the Institute of Measurement and Control 41, n. 6 (13 agosto 2018): 1750–60. http://dx.doi.org/10.1177/0142331218788125.

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This paper addresses the Sliding Mode Learning Control (SMLC) of uncertain nonlinear systems with Lyapunov stability analysis. In the control scheme, a conventional control term is used to provide the system stability in compact space while a type-2 neuro-fuzzy controller (T2NFC) learns system behaviour so that the T2NFC completely takes over overall control of the system in a very short time period. The stability of the sliding mode learning algorithm has been proven in the literature; however, it is restrictive for systems without overall system stability. To address this shortcoming, a novel control structure with a novel sliding surface is proposed in this paper, and the stability of the overall system is proven for nth-order uncertain nonlinear systems. To investigate the capability and effectiveness of the proposed learning and control algorithms, the simulation studies have been carried out under noisy conditions. The simulation results confirm that the developed SMLC algorithm can learn the system behaviour in the absence of any mathematical model knowledge and exhibit robust control performance against external disturbances.
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Nuha, Hilal H., Nachwan M. Andriansyah e Asep Mulyana. "Simulasi Penentuan Lokasi Perangkat Bergerak dengan Metode Enhanced Observed Time Difference". Jurnal Eksplora Informatika 9, n. 2 (31 marzo 2020): 111–23. http://dx.doi.org/10.30864/eksplora.v9i2.306.

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Sebagai alternatif Global Positioning System (GPS) yang berbasis satelit, jaringan seluler yang tersebar di berbagai daerah bisa digunakan untuk penentuan lokasi seperti Enhanced Observed Time Difference (EOTD) yang merupakah teknik penentuan lokasi menggunakan perangkat seluler seperti Base Transceiver Station (BTS) dan Mobile Station (MS). Sistem EOTD membutuhkan komponen tambahan BTS berupa Location Measurement Unit (LMU) dan Serving Mobile Location Center (SMLC). LMU berfungsi memberitahu MS tentang waktu pengiriman sinyal sedangkan SMLC berfungsi sebagai server yang menerima request dari MS dan LMU. Jarak antara MS dan BTS bisa diperkirakan dengan mengalikan selisih waktu dengan kecepatan cahaya. Dengan menggunakan dua buah jarak dari dua buah BTS, maka dua buah hiperbola bisa dibuat dengan titik pusat pada masing-masing koordinat BTS. Posisi dari MS bisa ditentukan dari titik temu dua hiperbola tersebut. Evaluasi teknik penentuan lokasi ini dilakukan dengan simulasi pada berbagai kondisi medan mulai dari kondisi diam dan bergerak dengan kecepatan tertentu dengan frekuensi carrier yang beragam. Sebagai perbandingan, untuk kondisi Non-Line of Sight (NLOS) pada model kanal urban 3GPP, simulasi sistem yang menggunakan laterasi dua buah kurva hiperbola dengan selisih pengukuran maksimum 0.0148 Km yang lebih akurat daripada metode pembanding Estimated-Time of Arrival (ETOA) dengan selisih pengukuran maksimum 0.31858 Km.
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Marx, M., P. Vacha, B. Riis, T. Feyerabend e E. Richter. "413Clinical use of a new simulation-multileaf-collimator (SMLC) in cervical cancer". Radiotherapy and Oncology 40 (gennaio 1996): S106. http://dx.doi.org/10.1016/s0167-8140(96)80422-1.

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Shaikh, Mubin, Jay Burmeister, Michael Joiner, Shalini Pandya, Bo Zhao e Qiang Liu. "Biological effect of different IMRT delivery techniques: SMLC, DMLC, and helical tomotherapy". Medical Physics 37, n. 2 (25 gennaio 2010): 762–70. http://dx.doi.org/10.1118/1.3284369.

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Orozco Rodríguez, Rafael, e Róger Muñoz Hernández. "Efecto de abonos orgánicos en las propiedades químicas del suelo y el rendimiento de la mora (Rubus adenotrichus) en dos zonas agroecológicas de Costa Rica". Revista Tecnología en Marcha 25, n. 1 (21 maggio 2012): 16. http://dx.doi.org/10.18845/tm.v25i1.173.

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<p>El objetivo de esta investigación es evaluar el efecto de dos abonos orgánicos en las propiedades quími- cas del suelo y el rendimiento de plantas de mora (<em>Rubus adenotrichus </em>cv.’Vino’) en dos zonas de Costa Rica.</p> <p>Para ello se establecieron dos experimentos, uno en Buena Vista de Pérez Zeledón (BVPZ) y otro en San Mar tín de León Cor tés (SMLC), ambos en la provin- cia de San José, Costa Rica. La investigación se realizó entre agosto del 2005 y julio del 2008.</p> <p>Se evaluaron tres tratamientos en cada experimen- to: Compost (C) y Lombricompost (L), a razón de 4 kg/planta y 3 kg/planta respectivamente, y un testi- go sin abono (T). La frecuencia de aplicación de los abonos a la siembra se dio a los 6, 12, 18 y 24 meses para un total de 6,6 t/ha para el C y 4,9 t/ha para el L. Se tomaron muestras de suelo a los 0, 6, 12, 18, 24 y 35 meses, después de la siembra para su análisis.</p> <p>Los resultados muestran que, en ambos agro-ecosis- temas, la aplicación del C y L incrementó el pH del suelo, redujo la acidez, incrementó la disponibilidad de Ca, Mg, K, N, y P, y favoreció la capacidad de in- tercambio catiónico efectiva (CICE) y el porcentaje de materia orgánica. No se observó acumulación de Mn, Cu y Zn.</p> <p>En cuanto al rendimiento, en BVPZ solo se encon- traron diferencias significativas (P=0,00188) entre C (1,8 t/ha) y el T (0,9 t/ha); mientras que en SMLC, no se encontraron diferencias estadísticas significativas (P&lt;0,05) entre los tratamientos.</p>
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FURUE, HIROKAZU, ISA NISHIYAMA, JUN YAMAMOTO, HIROSHI YOKOYAMA e JUN HATANO. "Molecular Alignment in SmLC Cells Having a Surface Layer with INS Phase Sequence". Ferroelectrics 310, n. 1 (gennaio 2004): 31–35. http://dx.doi.org/10.1080/00150190490510258.

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Liu, Qiang, Patrick McDermott e Jay Burmeister. "Effect of respiratory motion on the delivery of breast radiotherapy using SMLC intensity modulation". Medical Physics 34, n. 1 (26 dicembre 2006): 347–51. http://dx.doi.org/10.1118/1.2405323.

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Neethu, B., e M. M. Ghangrekar. "Electricity generation through a photo sediment microbial fuel cell using algae at the cathode". Water Science and Technology 76, n. 12 (11 settembre 2017): 3269–77. http://dx.doi.org/10.2166/wst.2017.485.

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Abstract Sediment microbial fuel cells (SMFCs) are bio-electrochemical devices generating electricity from redox gradients occurring across the sediment–water interface. Sediment microbial carbon-capture cell (SMCC), a modified SMFC, uses algae grown in the overlying water of sediment and is considered as a promising system for power generation along with algal cultivation. In this study, the performance of SMCC and SMFC was evaluated in terms of power generation, dissolved oxygen variations, sediment organic matter removal and algal growth. SMCC gave a maximum power density of 22.19 mW/m2, which was 3.65 times higher than the SMFC operated under similar conditions. Sediment organic matter removal efficiencies of 77.6 ± 2.1% and 61.0 ± 1.3% were obtained in SMCC and SMFC, respectively. With presence of algae at the cathode, a maximum chemical oxygen demand and total nitrogen removal efficiencies of 63.3 ± 2.3% (8th day) and 81.6 ± 1.2% (10th day), respectively, were observed. The system appears to be favorable from a resources utilization perspective as it does not depend on external aeration or membranes and utilizes algae and organic matter present in sediment for power generation. Thus, SMCC has proven its applicability for installation in an existing oxidation pond for sediment remediation, algae growth, carbon conversion and power generation, simultaneously.
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Più fonti

Tesi sul tema "SMLC"

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Williams, Matthew John Physics Faculty of Science UNSW. "Investigations into static multileaf collimator based intensity modulated radiotherapy". Awarded by:University of New South Wales. Physics, 2005. http://handle.unsw.edu.au/1959.4/20577.

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Intensity Modulated Radiation Therapy (IMRT) is a modern radiotherapy treatment technique used to obtain highly conformal dose distributions. The delivery of IMRT is commonly achieved through the use of a multileaf collimator (MLC). One of the hindrances at present to the widespread use of IMRT is the increased time required for its planning, delivery and verification. In this thesis one particular method of MLC based IMRT, known as Static Multileaf Collimator based IMRT (SMLC-IMRT), has been studied along with methods for improving it???s delivery efficiency. The properties of an MLC commonly used in SMLC-IMRT have been characterised. The potential ramifications of these properties on the dosimetric accuracy of the delivered IMRT field were also investigated. An Interactive Leaf Sequencing (ILS) program was developed that allowed for the manipulation and processing of intensity maps using a variety of methods. The objective of each method was to improve the delivery efficiency whilst maintaining the dosimetric quality of the IMRT treatment. The different methods investigated were collimator angle optimisation, filtration, and intensity level optimisation. The collimator was optimised by identifying the angle at which the minimum monitor unit???s (MU???s) were required when using a sliding-window delivery method. A Savitzky-Golay filter was applied to random intensity maps and suitable filtration parameters identified for filtering clinical IMRT fields, and the intensity levels were optimised based on a deviation threshold. The deviation threshold identified the acceptable level of difference tolerable between the original and modified intensity map. Several IMRT cases were investigated and the impact of each the methods on MU???s, segments and dose distribution observed. As the complexity of IMRT fields increases the dosimetric impact of the MLC properties increases. Complex SMLC-IMRT fields require longer delivery times due to the increased number of MU???s and segments. Collimator optimisation was shown to be a fast and effective means of improving delivery efficiency with negligible dosimetric change to the optimised plan. Modifying intensity maps by applying a filter and optimising the intensity levels did reduce the complexity and improve the delivery efficiency, but also required a dosimetric compromise of the optimised plan.
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Oliveira, Freire Ricardo. "Desenvolvimento de Modelos Químico - Quânticos para o Estudo de Complexos com Íons Lantanídeos e Actinídeos". Universidade Federal de Pernambuco, 2004. https://repositorio.ufpe.br/handle/123456789/8975.

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Made available in DSpace on 2014-06-12T23:03:37Z (GMT). No. of bitstreams: 2 arquivo9526_1.pdf: 10435939 bytes, checksum: 5999b540f1487bd08bd32fdc679af9c5 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2004
Desde a sua concepção em 1994, o modelo SMLC, Sparkle Model for Lanthanide Complexes, tem sido utilizado apenas para o cálculo das geometrias do estado fundamental de complexos de Eu(III). Neste trabalho, aperfeiçoamos em muito este modelo para o íon Eu(III) e iniciamos o procedimento de extensão do mesmo para os outros íons lantanídeos. Desenvolvemos também uma versão do modelo para actinídeos, SMAC/AM1, em particular para o íon Th(IV). No processo de parametrização destes modelos, dois pontos são de fundamental importância: (i) a escolha de um conjunto de treinamento capaz de representar bem o nosso universo de estruturas de complexos e (ii) a escolha de uma função resposta capaz de possibilitar a reprodução satisfatória das propriedades de interesse, que no nosso caso foram comprimentos e ângulos de ligação envolvendo o íon metálico. Na primeira etapa, a escolha certa de um pequeno, mas representativo conjunto de treinamento foi fundamental, pois no processo de parametrização estas estruturas foram calculadas milhares de vezes até que os parâmetros capazes de reproduzir mais exatamente as estruturas cristalográficas fossem encontrados. Por este motivo, realizamos uma análise de agrupamentos hierárquicos para cada íon utilizando todas as estruturas disponíveis no CSD (Cambridge Structural Database 2003). Esta análise resultou, em geral, na classificação das estruturas em sete grupos distintos onde o critério de separação foi o tipo de ligante presente no complexo. Assim, foi possível, para todos os íons parametrizados, escolher um conjunto de treinamento pequeno, mas capaz de representar qualquer tipo de complexo contendo o íon em questão. Na outra etapa, resolvemos adotar uma função resposta em que as propriedades consideradas, no nosso caso distâncias e ângulos de ligação, estivessem intimamente relacionadas com os parâmetros do íon que estávamos buscando. Esta nova função resposta é composta de duas parcelas: a primeira delas é igual ao quadrado da diferença entre as distâncias interatômicas experimentais, Ri exp e calculadas, Ri calc, que envolvem o íon metálico multiplicado por um peso wi e a segunda parcela é a diferença entre os ângulos experimentais, i exp e os calculados, i calc, em que o íon metálico encontra-se no vértice, multiplicada por um peso wj. Durante o procedimento de parametrização para o íon Eu(III), o primeiro dos lantanídeos a ser parametrizado, inúmeros testes foram realizados e cada termo da função resposta foi exaustivamente analisado até que conseguíssemos encontrar um conjunto de parâmetros que tornasse o nosso método realmente robusto. Com o mesmo procedimento utilizado na concepção dos parâmetros do íon Eu(III), parametrizamos os íons Gd(III) e Tb(III) e estendemos a metodologia para actinídeos - Th(IV). Os modelos foram validados de duas formas distintas. A primeira delas foi através de conjuntos testes contendo várias estruturas para cada íon. A outra forma de validação, foi a realização de cálculos ab initio RHF/STO-3G/ECP para sete estruturas representativas de cada um dos grupos obtidos pela análise de agrupamentos. A análise dos resultados obtidos mostrou que para o íon Eu(III) esta nova versão resolveu vários problemas detectados na versão anterior, SMLC II. Dentre os mais importantes estão: (i) a capacidade de predizer, muito bem, estruturas com qualquer tipo de ligante, ao contrário do SMLC II que só era capaz de predizer muito bem estruturas com ligantes do tipo -dicetonas; (ii) correção dos ligantes nitratos, que nas versões anteriores coordenavam-se de forma monodentada ao íon Eu(III) e que nesta nova versão passaram a coordenar-se corretamente (ligante bidentado); (iii) uma melhora razoável na descrição de ligantes pequenos, como água ou isotiocianato. O avanço do modelo SMLC/AM1 para o íon Eu(III) foi de tal forma significativo que nos possibilitou compará-lo com resultados obtidos a partir de metodologias ab initio. O mesmo foi feito para os outros íons lantanídeos e actnídeos estudados. Para o íon európio (III) o erro médio absoluto obtido com o modelo SMLC/AM1 foi de 0,115 Å e a metodologia ab initio RHF/STO-3G/ECP apresentou um erro médio absoluto de 0,123 Å, ou seja, o modelo SMLC/AM1 foi 6% mais exato. Para os íons Gd(III) e Tb(III), o modelo SMLC/AM1 foi, respectivamente, 16% e 31% mais exato que a metodologia ab initio utilizada. No caso do íon actinídeo Th(IV), o erro médio absoluto obtido com o modelo SMAC/AM1 foi de 0,126 Å e a metodologia ab initio utilizada apresentou um erro de 0,113 Å. Neste caso, o modelo SMAC/AM1 ficou a apenas 10% da metodologia RHF/STO-3G/ECP. Com base nos resultados obtidos com este trabalho, podemos então afirmar que os modelos SMLC/AM1 e SMAC/AM1 apresentaram um nível de exatidão comparável ou, em alguns casos, superior ao da metodologia ab initio, RHF/STO-3G/ECP, na predição, tanto das distâncias entre o íon Ln(III) ou Ac(IV) e os átomos que compõem o poliedro de coordenação, como também entre os átomos do poliedro
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Hunter, Allison M. "Smac-based antagonists of the inhibitors of apoptosis". Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/29351.

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Apoptosis signal pathways converge on the Caspases, a family of proteases that form a self-amplifying cascade, the activation of which generates the characteristic morphological and biochemical features of apoptotic cell death. The Inhibitors of Apoptosis (IAPs) are a family of proteins that bind and inactivate Caspases at both the initiation and terminal effector stages of this cascade. Over-expression of IAPs, as observed in cancer cell lines and tumour biopsy samples, results in a cellular phenotype of resistance to a variety of apoptotic stresses including chemotherapeutic drugs and irradiation. One negative regulator of IAP function, Smac (second mitochondrial activator of Caspases a.k.a.Diablo) has been identified as a mitochondrial protein that is processed and released concomitantly with cytochrome c following an apoptotic stress. Proteolytic processing of the mitochondrial signal peptide sequence generates a novel amino terminus that interacts with XIAP and disrupts XIAP-meditated Caspase-9 inhibition. By disrupting the interaction of XIAP with Caspase-9, Smac is believed to promote apoptotis. Furthermore, the structure determinations of XIAP, in conjunction with either Caspases or Smac, have led to the identification of a critical pocket and groove on the surface of each BIR domain ( Baculovirus IAP Repeat). Within XIAP BIR3, the binding pocket interacts with Caspase-9 and can be disrupted by the presence of Smac, which competes for the same site. In this thesis work, the utility of Smac as a chemo-sensitizing agent for the treatment of cancer was enhanced by three different strategies. The first approach involved the development and characterization of an ubiquitin-Smac fusion system that circumvents the targeting of Smac to the mitochondria and results in the expression of a fully mature, biologically active Smac protein. The second approach entailed developing a strategy for increasing the affinity of Smac binding to the IAPs. A random peptide phage display screen was used to identify novel, high affinity peptide ligands that bind to the IAP-BIR3 motifs. These peptide sequences were similar in structure to the amino terminus of Smac and Caspase-9. The data generated from these two approaches showed that both over-expressed, mature Smac and Smac-like peptide sequences bind to the IAPs in vitro and in vivo and sensitize cells to chemotherapeutic drugs. The third and final approach involved developing a Smac system that was a more potent apoptosis-inducer than wild-type Smac, which would be predicted to have greater therapeutic potential. It has been shown that Smac interactions with the IAP BIR domains may accelerate IAP auto-ubiquitination and destruction via the IAP carboxy terminal RING (Really Interesting New Gene) domain. Adding an IAP-RING domain to the carboxy terminus of Smac was predicted to enhance IAP degradation while maintaining the IAPs in a non-functional protein complex. Indeed, it was observed that generating a Smac protein with RING-conferred E3 ligase activity significantly decreased IAP levels, with a concomitant increase in the sensitivity to apoptosis in the presence of chemotherapeutic agents.
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Buermann, Frank. "Architecture of SMC-kleisin complexes". Diss., Ludwig-Maximilians-Universität München, 2015. http://nbn-resolving.de/urn:nbn:de:bvb:19-183573.

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In all cellular systems, the transmission of bulk genetic information during proliferation occurs in the form of chromosomes. The segregation of these entities upon cell division is of pivotal importance for all forms of life. Structural maintenance of chromosomes (SMC)-kleisin complexes are ubiquitous and essential factors that ensure proper organisation and segregation of the genetic material. Aim of this work was to elucidate evolutionary conserved features in the architecture of SMC-kleisin complexes, and to probe these features for functional relevance. We find that two major architectural themes have been constrained by evolution: (I) SMC-kleisin complexes form asymmetric assemblies with a ring-like topology, whereby a kleisin monomer bridges two different binding sites on a SMC dimer, (II) SMC-kleisin complexes form rod-like structures, whereby the SMC proteins of a given dimer are closely juxtaposed in a well-defined manner. Based on these findings, we propose that SMC-kleisin complexes from all domains of life act by a unifying mechanism.
Die universellen Träger genetischer Information bei der Vermehrung zellulären Lebens sind die Chromosomen. Die Segregation dieser Einheiten während der Zellteilung ist für alle Organismen unabdingbar. Structural Maintenance of Chromosomes (SMC)-Kleisin-Komplexe sind universelle und essentielle Faktoren, welche die korrekte Organisation und Segregation des Erbmaterials sicherstellen. Ziel dieser Arbeit war es, evolutionär konservierte Erscheinungsmerkmale von SMC-Kleisin-Komplexen aufzudecken, und diese Merkmale auf funktionelle Relevanz zu testen. Wir haben zwei evolutionär invariante Leitmotive der Architektur von SMC-Kleisin-Komplexen identifiziert: (I) SMC-Kleisin-Komplexe haben eine asymmetrische Konfiguration, in der ein Kleisin-Monomer zwei unterschiedliche Bindungsstellen eines SMC-Dimers miteinander verbindet, (II) SMC-Kleisin-Komplexe bilden stäbchenförmige Strukturen, in denen die SMC-Proteine eines Dimers in einer wohl definierten Art eng aneinander liegen. Basierend auf diesen Resultaten schlagen wir vor, dass sämtliche SMC-Kleisin-Komplexe aus allen phylogenetischen Domänen einen gemeinsamen Funktionsmechanismus haben.
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Knust, Tobias [Verfasser], e Peter [Akademischer Betreuer] Graumann. "Regulation of SMC by associate proteins and ATP = Regulation von SMC durch assoziierte Proteine und ATP". Freiburg : Universität, 2011. http://d-nb.info/112345888X/34.

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Higgins, Julia. "An exploration of novel physiological roles for Smac/DIABLO". Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110467.

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Abstract (sommario):
Second mitochondrial-derived activator of caspases (Smac), also known as direct IAP-binding protein with low pI (DIABLO) is known as a proapoptotic protein that inhibits the inhibitors of apoptosis family (IAPs). The members of the IAP family were characterized by their ability to inhibit proapoptotic caspases. More recently, the IAPs have also been shown to play major roles in regulating diverse signalling events within the cell. A physiological role for Smac remains elusive, but studies have focused primarily on its roles in regulating the IAPs in the context of apoptosis. In order to critically evaluate possible physiological roles for Smac, we sought to examine non-apoptotic signalling events regulated by the IAPs, including NF-κB induction, mitochondrial antiviral (MAVS) signalling, and necroptosis. While Smac knockdown revealed no obvious roles for Smac in context of MAVS signalling or NF-κB induction, we found that Smac contributes to necroptosis induction in L929 cells. While we hypothesized that Smac null mice would be protected from necroptosis induced by experimental colitis, we unexpectedly found that colitis was more severe in Smac null mice than in wild-type mice. Further investigation of how Smac is involved in the reaction to induced colitis might reveal a physiological role for Smac.
"Second mitochondrial-derived activator of caspases" (Smac), aussi connu sous le nom de DIABLO pour "direct IAP-binding protein with low pI", est une protéine proapoptotique qui effectue son rôle en interagissant avec et inhibant l'action des membres de la famille des inhibiteurs d'apoptose (IAP). Les membres de la famille des IAP ont été caractérisés par leur capacité d'inhiber l'action des caspases proapoptotiques prévenant ainsi l'apoptose cellulaire. Les IAP sont aussi engagés dans diverses autres voies de signalisation, hormis leur rôle dans la régulation de l'apoptose. L'effet de Smac sur les IAP a été étudié dans le contexte de l'apoptose cellulaire et aucun autre rôle physiologique ne lui a été attribué jusqu'à nos jours. Afin d'évaluer diverses possibilités de rôles physiologiques pour Smac, nous désirions examiner les voies de signalisation non-apoptotiques régulées par les IAP, incluant l'induction de NF-κB, la signalisation antivirale mitochondriale (MAVS) ainsi que la nécroptose.Nos résultats révèlent que la sous expression de Smac n'affecte pas l'induction de NF-κB et n'interfère pas avec la voie de signalisation engagée par les MAVS. Par contre Smac induit la mort des cellules L929 par nécroptose.Pour examiner l'effet de Smac in vivo nous avons étudié son rôle dans un modèle de colite expérimentale. Nos résultats révèlent que les souris mutantes rendues nulles pour le gène Smac présentent une colite plus sévère que les souris à phénotype sauvage. Il serait ainsi nécessaire d'examiner de plus près la régulation de Smac dans le modèle de colite expérimentale pour essayer de mieux comprendre son rôle physiologique.
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Hasenjäger, Anne. "Mechanismen der Apoptoseinduktion durch das proapoptotische Protein Smac/DIABLO". [S.l.] : [s.n.], 2004. http://www.diss.fu-berlin.de/2005/4/index.html.

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Sexton, David James. "Investigating the functional role of SMOC-1 in zebrafish". Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/22907.

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True anophthalmia is the most severe congenital eye malformation. With absence of the eye, optic nerve, chiasm and optic tracts. Identifying the genes that cause genetic true anophthalmia should improve our understanding of the critical processes required for development of the eye. Recessive loss-of-function mutations in SMOC1 have been identified as the cause of Ophthalmo-acromelic syndrome (OAS), a multisystem disorder which has true anophthalmia as a prominent feature with characteristic limb and facial malformations. In order to establish the function of SMOC1 in development I used the zebrafish as a model organism to support a link between SMOC-1 and BMP signalling. As a first step I characterised the genomic structure of zebrafish smoc1 gene. I was able to correct an error in the zebrafish genome (Zv8) that annotated zsmoc1 as two fragmented and rearranged orthologous loci. However, using RTPCR I could show that there is in fact a single intact zsmoc1 transcript. In addition, I was able to identify an un-annotated 5’ coding exon using 5' RACE which showed that the full open reading frame includes a signalling peptide. RT-PCR was also used to identify several novel zsmoc1 splice isoforms. To explore the link between zsmoc1 and bmp signalling I used injection of antisense morpholino oligonucleotide and capped mRNA to examine the effects of loss-of-function and overexpression respectively of smoc1 and genes functioning in the bmp signalling pathway. The resulting embryos were analysed using morphometric analysis (Kishimoto scale), a quantitative assay of dorsalisation/ventralisation and live imaging of reporter transgenic fish. I developed a quantitative RT-PCR assay for expression of dorsal (otx2 and runx3) and ventral (eve1 and gata2) marker genes. I established a reliable system for live imaging of zebrafish development between 8 hpf and 24 hpf. By combining this system with fluorescent transgenic reporters marking the eye field (rx3:gfp reporter) and BMP-signaling (BRE:gfp reporter) I was able to accurately quantitate the effect of smoc1 depletion on eye size and SMAD1/5/8 signalling in the eye. These results support the predictions from the Drosophila homologue Pent that zsmoc1 functions as an antagonist of bmp signalling. Finally, I describe my attempt to produce a zebrafish model for OAS using genome editing technology. I designed, produced and validated transcription activator like effectors nucleases (TALENs) targeted to the zsmoc1 open reading frame using the Voytas Goldengate method. I designed and optimised a novel strategy to demonstrate targeted cutting activity for in vitro validation. Following injections of the in vitro validated TALEN into zebrafish embryos I used Ion Torrent sequencing to assess the in vivo activity of the engineered TALEN pairs. Unfortunately these TALENs were not able to cut the targeted locus in vivo.
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Ďuriš, Martin. "Řízení modelu linky SMC MAP 205". Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2015. http://www.nusl.cz/ntk/nusl-232001.

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The thesis deal with a model of electronically controlled assembly minicell MAP-205 based on pneumatic drives and its debugging. Assembly minicell simulates assembling and disassembling of simple four item assembly. Minicell is controlled by Phoenix Contact ILC 150ETH programmable logic controller. The minicell control program is composed of several subroutines/subprograms providing various functionalities to assembly minicell. There is integrated HMI created in Control Web application too. It allows to display actual status of each component and to control each drive in manual mode. Communication between HMI based on PC and PLC controller is supported by Bluetooth module and OPC server.
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Justino, Joana Filipa Fernandes Mendes. "Survivin and Smac/DIABLO: role of apoptosis in experimental PAH". Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/13362.

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Mestrado em Bioquímica - Bioquímica Clínica
Pulmonary hypertension (PH) is a multifactorial, progressive disease, characterized by vasoconstriction, pulmonary vascular remodelling and thrombosis in situ, which lead to augmentation of pulmonary arterial pressure and pulmonary vascular resistance, culminating in right heart failure and ultimately in dead. Pulmonary vascular remodelling, which is one of the major contributors to the development and progression of PH, is characterized by excessive cellular proliferation and reduced apoptosis. However, little is known about the molecular mechanisms underlying this imbalance. So, the present work aimed to study the contribution of apoptosis to the pathogenesis of PAH, through the analysis of cardiac and pulmonary expression of survivin and Smac/DIABLO along hemodynamic and morphometric alterations in an animal model of monocrotaline (MCT)-induced PAH. Results showed that cardiomyocytes were hypertrophied 7 days after MCT injection, preceeding hemodynamic alterations which were only present at day 21. Seven days after MCT administration, survivin overexpression was notorious in the ventricles and progressively increased throughout the development of MCT-induced PAH. On the other hand, although increased 7 days after MCT injection, lung survivin expression progressively decreased between the two days. The upregulation of Smac/DIABLO observed in lung, right and left ventricles 7 days after MCT administration, progressively decreased with the disease progression. In conclusion, data suggest that a deregulation in the balance between survivin and smac/DIABLO might be related with pulmonary vascular remodelling and cardiomyocytes hypertrophy in response to apoptotic stimuli.
A hipertensão pulmonar (HP), é uma doença multifactorial e progressiva, caracterizada pela vasoconstrição, remodelação vascular pulmonar e trombose in situ, com consequente aumento da pressão arterial pulmonar e da resistência vascular pulmonar, frequentemente culminando na insuficiência cardíaca direita e morte. A remodelação vascular pulmonar, um dos principais contribuintes para o desenvolvimento e progressão da HP, é caracterizada por uma proliferação celular excessiva e uma reduzida apoptose. No entanto, pouco se sabe sobre os mecanismos moleculares subjacentes a este desequilíbrio. Assim, o presente trabalho teve como objetivo principal a avaliação da contribuição da apoptose na patogénese da HAP, através da análise da expressão cardíaca e pulmonar da survivina e do Smac/DIABLO e a sua associação às alterações hemodinâmicas e morfométricas. Para o efeito utilizou-se um modelo animal de HAP induzida por administração de monocrotalina (MCT). Os resultados demonstraram que os cardiomiócitos se encontravam hipertrofiados 7 dias após a injeção de MCT o que precedeu as alterações hemodinâmicas que se verificaram apenas ao dia 21. Sete dias após a administração de MCT observou-se sobreexpressão de survivina nos ventrículos, tendo esta aumentado progressivamente com a doença. A nível pulmonar, embora sobreexpressa ao dia 7, a expressão de survivin diminuiu com o desenvolvimento da doença. Apesar de sobreexpressa nos ventrículos e no pulmão 7 dias após injeção de MCT, a expressão do Smac/DIABLO diminuiu progressivamente com a HAP. Em conclusão, os resultados sugerem que a desregulação das vias de sinalização nas quais intervêm a survivina e o Smac/DIABLO está relacionada com a remodelação vascular pulmonar e a hipertrofia dos cardiomiócitos em resposta a estímulos apoptóticos.
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Libri sul tema "SMLC"

1

Badrinarayanan, Anjana, a cura di. SMC Complexes. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9520-2.

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2

Racault, Sylvie. Réflexions sur l'alignement du SMIC. Saint-Denis: Observatoire du développement de la Réunion, 1997.

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Federighi, Paolo, e Francesca Torlone, a cura di. SMOC – Método Abierto de Coordinación de Prevalet. Florence: Firenze University Press, 2011. http://dx.doi.org/10.36253/978-88-6453-267-7.

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Seven European Regional Governments, together with Earlall and universities and research centres, have undertaken to refine a first draft of a Joint Progress Report of Regions on Implementation of European Lifelong Learning Strategies in the perspective of the Europe 2020 Strategy. The purpose of this exercise is to demonstrate the usefulness and need to make an instrument available to European Regional Governments that helps to understand and evaluate the educational conditions of the regional population when compared with other regions. The Report shows how, over the decade, all the Regional Governments have undertaken to adapt training systems to the demographic dynamics characterised by the general ageing of the population and by migratory phenomena. Simultaneously the Report also shows the need for urgent improvements in some fields where the impact of policies is still too modest and where the risk of stagnation must be dealt with (for example, lifelong learning policies and NEET reduction).
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Federighi, Paolo, e Francesca Torlone, a cura di. SMOC-Soft Open Method of Coordination from Prevalet. Florence: Firenze University Press, 2011. http://dx.doi.org/10.36253/978-88-6453-246-2.

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Abstract (sommario):
Seven European Regional Governments, together with Earlall and universities and research centres, have undertaken to refine a first draft of a Joint Progress Report of Regions on Implementation of European Lifelong Learning Strategies in the perspective of the Europe 2020 Strategy. The purpose of this exercise is to demonstrate the usefulness and need to make an instrument available to European Regional Governments that helps to understand and evaluate the educational conditions of the regional population when compared with other regions. The Report shows how, over the decade, all the Regional Governments have undertaken to adapt training systems to the demographic dynamics characterised by the general ageing of the population and by migratory phenomena. Simultaneously the Report also shows the need for urgent improvements in some fields where the impact of policies is still too modest and where the risk of stagnation must be dealt with (for example, lifelong learning policies and NEET reduction).
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Federighi, Paolo, e Francesca Torlone, a cura di. SMOC-Metodo Aperto e Semplificato di Coordinamento da Prevalet. Florence: Firenze University Press, 2011. http://dx.doi.org/10.36253/978-88-6453-254-7.

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Abstract (sommario):
Seven European Regional Governments, together with Earlall and universities and research centres, have undertaken to refine a first draft of a Joint Progress Report of Regions on Implementation of European Lifelong Learning Strategies in the perspective of the Europe 2020 Strategy. The purpose of this exercise is to demonstrate the usefulness and need to make an instrument available to European Regional Governments that helps to understand and evaluate the educational conditions of the regional population when compared with other regions. The Report shows how, over the decade, all the Regional Governments have undertaken to adapt training systems to the demographic dynamics characterised by the general ageing of the population and by migratory phenomena. Simultaneously the Report also shows the need for urgent improvements in some fields where the impact of policies is still too modest and where the risk of stagnation must be dealt with (for example, lifelong learning policies and NEET reduction).
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6

Hariadi, Agustinus. SML ISO 14001: Interpretasi, dokumentasi, dan implementasi. Jakarta: Paradigma Pustaka, 2003.

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7

Bhagooa, Alixe Anne. XGenealogy: Genealogy representation software using SML and XSLT. Oxford: Oxford Brookes University, 2004.

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8

Federighi, Paolo, e Francesca Torlone, a cura di. SMOC – Sanfte offene Koordinierungsmethode – Soft Open Method of Coordination von Prevalet. Florence: Firenze University Press, 2011. http://dx.doi.org/10.36253/978-88-6453-263-9.

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Abstract (sommario):
Seven European Regional Governments, together with Earlall and universities and research centres, have undertaken to refine a first draft of a Joint Progress Report of Regions on Implementation of European Lifelong Learning Strategies in the perspective of the Europe 2020 Strategy. The purpose of this exercise is to demonstrate the usefulness and need to make an instrument available to European Regional Governments that helps to understand and evaluate the educational conditions of the regional population when compared with other regions. The Report shows how, over the decade, all the Regional Governments have undertaken to adapt training systems to the demographic dynamics characterised by the general ageing of the population and by migratory phenomena. Simultaneously the Report also shows the need for urgent improvements in some fields where the impact of policies is still too modest and where the risk of stagnation must be dealt with (for example, lifelong learning policies and NEET reduction).
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9

Smoc Gron Bach. Y Lolfa, 1994.

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10

Bookcover-Sml-Hunter. Gregg Manufacturing, 1994.

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Capitoli di libri sul tema "SMLC"

1

Suski, W., e T. Palewski. "SmLn"2S4". In Pnictides and Chalcogenides II, 1641. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/10713485_638.

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Balaji, Raghunathan, e V. Maiya Rajashekara. "SMAC Primer". In SMACing the Bank, 29–132. Boca Raton, FL : CRC Press, 2017.: Auerbach Publications, 2017. http://dx.doi.org/10.1201/9781315119632-2.

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Gooch, Jan W. "SMC". In Encyclopedic Dictionary of Polymers, 672. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_10787.

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4

Utkin, Vadim, Alex Poznyak, Yury V. Orlov e Andrey Polyakov. "Adaptive SMC". In SpringerBriefs in Mathematics, 99–108. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-41709-3_9.

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Chopin, Nicolas, e Omiros Papaspiliopoulos. "SMC Samplers". In Springer Series in Statistics, 329–55. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-47845-2_17.

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Agarwal, Pratyush, Krishnendu Chatterjee, Shreya Pathak, Andreas Pavlogiannis e Viktor Toman. "Stateless Model Checking Under a Reads-Value-From Equivalence". In Computer Aided Verification, 341–66. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-81685-8_16.

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AbstractStateless model checking (SMC) is one of the standard approaches to the verification of concurrent programs. As scheduling non-determinism creates exponentially large spaces of thread interleavings, SMC attempts to partition this space into equivalence classes and explore only a few representatives from each class. The efficiency of this approach depends on two factors: (a) the coarseness of the partitioning, and (b) the time to generate representatives in each class. For this reason, the search for coarse partitionings that are efficiently explorable is an active research challenge.In this work we present $${\text {RVF-SMC}}$$ RVF-SMC , a new SMC algorithm that uses a novel reads-value-from (RVF) partitioning. Intuitively, two interleavings are deemed equivalent if they agree on the value obtained in each read event, and read events induce consistent causal orderings between them. The RVF partitioning is provably coarser than recent approaches based on Mazurkiewicz and “reads-from” partitionings. Our experimental evaluation reveals that RVF is quite often a very effective equivalence, as the underlying partitioning is exponentially coarser than other approaches. Moreover, $${\text {RVF-SMC}}$$ RVF-SMC generates representatives very efficiently, as the reduction in the partitioning is often met with significant speed-ups in the model checking task.
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Lundén, Daniel, Johannes Borgström e David Broman. "Correctness of Sequential Monte Carlo Inference for Probabilistic Programming Languages". In Programming Languages and Systems, 404–31. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-72019-3_15.

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AbstractProbabilistic programming is an approach to reasoning under uncertainty by encoding inference problems as programs. In order to solve these inference problems, probabilistic programming languages (PPLs) employ different inference algorithms, such as sequential Monte Carlo (SMC), Markov chain Monte Carlo (MCMC), or variational methods. Existing research on such algorithms mainly concerns their implementation and efficiency, rather than the correctness of the algorithms themselves when applied in the context of expressive PPLs. To remedy this, we give a correctness proof for SMC methods in the context of an expressive PPL calculus, representative of popular PPLs such as WebPPL, Anglican, and Birch. Previous work have studied correctness of MCMC using an operational semantics, and correctness of SMC and MCMC in a denotational setting without term recursion. However, for SMC inference—one of the most commonly used algorithms in PPLs as of today—no formal correctness proof exists in an operational setting. In particular, an open question is if the resample locations in a probabilistic program affects the correctness of SMC. We solve this fundamental problem, and make four novel contributions: (i) we extend an untyped PPL lambda calculus and operational semantics to include explicit resample terms, expressing synchronization points in SMC inference; (ii) we prove, for the first time, that subject to mild restrictions, any placement of the explicit resample terms is valid for a generic form of SMC inference; (iii) as a result of (ii), our calculus benefits from classic results from the SMC literature: a law of large numbers and an unbiased estimate of the model evidence; and (iv) we formalize the bootstrap particle filter for the calculus and discuss how our results can be further extended to other SMC algorithms.
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Baum, G. "The SMC Experiment". In High Energy Spin Physics, 407–10. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-86995-2_38.

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Xia, Yuanqing, e Mengyin Fu. "Overview of SMC". In Compound Control Methodology for Flight Vehicles, 1–19. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-36841-7_1.

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Sestoft, Peter. "Compiling Micro-SML". In Undergraduate Topics in Computer Science, 253–81. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60789-4_13.

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Atti di convegni sul tema "SMLC"

1

Althani, Bashair, e Souheil Khaddaj. "The Applicability of System Migration Life Cycle (SMLC) Framework". In 2017 16th International Symposium on Distributed Computing and Applications to Business, Engineering and Science (DCABES). IEEE, 2017. http://dx.doi.org/10.1109/dcabes.2017.38.

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Nagarale, Ravindrakumar, R. H. Chile, B. M. Patre e Pramod A. Kulkarni. "Comparative Study of SMC and SMFLC Robustness Property". In 2007 International Conference on Mechatronics and Automation. IEEE, 2007. http://dx.doi.org/10.1109/icma.2007.4303708.

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Thomas, W. J. R., e A. J. Higson. "An Intercooled Regenerative Rolls-Royce Spey Gas Turbine". In ASME 1985 Beijing International Gas Turbine Symposium and Exposition. American Society of Mechanical Engineers, 1985. http://dx.doi.org/10.1115/85-igt-59.

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This paper aims to describe very briefly the Rolls-Royce 18 MW SMIC marine Spey gas turbine, the development of which was dealt with in more detail in reference 1, and then to show how intercooling and regeneration could be added to increase its power to about 22 MW, with an associated increase in thermal efficiency to about 43%. As the SM1C based “ICR” unit is still very much in the infancy of its design, this paper does not discuss the design in detail; indeed, the details are certainly not all within the Rolls-Royce design sphere, as the Allison Gas Turbine Division of General Motors Corporation and Garrett AiResearch are partners of Rolls-Royce Limited and Rolls-Royce Inc. in the project. The broad principles of the improved cycle are described and then the effects of the use of such a unit on the operational characteristics of warships are discussed, comparing them with those of warships using simple cycle Spey SM1C units in different installation configurations. This paper stands on its own, but may also be regarded as the second part of reference 1.
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Tamura, Atsutaka, e Yuya Kato. "Modeling Prestress-Driven Buckling Behavior of Elastic Lamina in the Aortic Media". In ASME 2019 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/imece2019-10530.

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Abstract Mathematical modeling of the thoracic aorta is important for understanding the development and progression of various cardiovascular diseases, helping to detect extraordinary stress distributions of the hypertensive aortic wall, even in early stages. However, it is difficult to ensure the biofidelity of biological materials in formulating a mathematical model. In a freshly isolated aortic media, composed mainly of smooth muscle cell layers (SMLs) and elastic laminae (ELs), circumferential EL waviness and longitudinal EL undulation are often observed because of the structural “buckling” of ELs. This is considered to be closely associated with residual stresses of SMLs and ELs in the aortic wall but the mechanism underlying such EL buckling behavior remains unclear. In the present study, a series of numerical simulations were designed to identify effective mechanical parameters to reproduce EL buckling in the aortic media. We found that prestress initially administered to ELs in the circumferential and axial directions, and the predefined internodal distance, which couples the SML and EL, are essential to computationally reconstruct the circumferential EL waviness and the longitudinal EL undulation in an unloaded state. We also proposed a set of equations based on the numerical results and successfully predicted EL buckling behaviors of the aorta in vitro.
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Li, Lele, e Zhibin Yu. "SMHC". In the 2019 4th International Conference. New York, New York, USA: ACM Press, 2019. http://dx.doi.org/10.1145/3335484.3335519.

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Pelosi, Gerardo, e Giuseppe Psaila. "SMaC". In the 2010 ACM Symposium. New York, New York, USA: ACM Press, 2010. http://dx.doi.org/10.1145/1774088.1774476.

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Song, Junghwan, Munyoung Lee e Ted "Taekyoung" Kwon. "SMIC". In ICN '18: 5th ACM Conference on Information-Centric Networking. New York, NY, USA: ACM, 2018. http://dx.doi.org/10.1145/3267955.3267971.

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Günnemann, Stephan, Ines Färber, Matthias Rüdiger e Thomas Seidl. "SMVC". In KDD '14: The 20th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining. New York, NY, USA: ACM, 2014. http://dx.doi.org/10.1145/2623330.2623734.

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McHenry, Brian G., e Raymond R. McHenry. "SMAC-87". In SAE International Congress and Exposition. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 1988. http://dx.doi.org/10.4271/880227.

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Yang, Yuhan, Lijun Wei, Jing Wu e Chengnian Long. "Block-SMPC". In ICBCT'20: 2020 The 2nd International Conference on Blockchain Technology. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3390566.3391664.

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Rapporti di organizzazioni sul tema "SMLC"

1

Balkwill, David L. The DOE Subsurface Microbial Culture Collection (SMCC). Office of Scientific and Technical Information (OSTI), maggio 2006. http://dx.doi.org/10.2172/882497.

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Srivastava, Rakesh K. Therapeutic Potential of a Novel Smac/DIABLO in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, febbraio 2005. http://dx.doi.org/10.21236/ada443883.

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Handy, L. E. ''SMAC'' - Sonic Mapping and Caliper research and development. Final report, Phase IB. Office of Scientific and Technical Information (OSTI), dicembre 1985. http://dx.doi.org/10.2172/6200227.

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Fox, M., C. Kassimis e J. Stevens. IBM's Shared Memory Communications over RDMA (SMC-R) Protocol. RFC Editor, agosto 2015. http://dx.doi.org/10.17487/rfc7609.

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White, Greg R. An SML Driven Graphical User Interface and Application Management Toolkit. Office of Scientific and Technical Information (OSTI), gennaio 2002. http://dx.doi.org/10.2172/798994.

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Zhang, Xiaoling. Inhibitory effecT of quercetin on protein expression CtBP1 and migration of hepatocellular carcinoma cell SMMC-7721. Science Repository, giugno 2018. http://dx.doi.org/10.31487/j.cor.2018.02.001.

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AIR FORCE SPACE COMMAND SPACE MISSILE SYS CTR. Space and Missile Systems Center Tailoring: Tailoring of Risk Management Requirements in SMC-S-001 (2013). Fort Belvoir, VA: Defense Technical Information Center, gennaio 2014. http://dx.doi.org/10.21236/ada619441.

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Chervak, Michelle, Tyson Grier, Ryan Steelman, Morgan Anderson e Bruce Jones. Evaluation of Student Injuries at the Sergeants Major Course (SMC), Fort Bliss, Texas, August 2013-May 2014. Fort Belvoir, VA: Defense Technical Information Center, giugno 2016. http://dx.doi.org/10.21236/ad1012898.

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Hurst, Jestin. Lagoon Seepage Testing Plan for the Specific Manufacturing Capability (SMC) Complex Sewage Lagoons at Idaho National Laboratory, Butte County, Idaho. Office of Scientific and Technical Information (OSTI), giugno 2018. http://dx.doi.org/10.2172/1484699.

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Theodore, George. Investigation of the Role of Sialomucin Complex (SMC)/Muc4, a Unique Intramembranous HER-2/ErbB-2 Ligand as a Suppressor of Apoptosis. Fort Belvoir, VA: Defense Technical Information Center, aprile 2004. http://dx.doi.org/10.21236/ada426336.

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