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Articoli di riviste sul tema "Smart nanoparticles"

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Autore: Grafiati

Pubblicato: 8 giugno 2024

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1

Jia, Lina, Peng Zhang, Hongyan Sun, Yuguo Dai, Shuzhang Liang, Xue Bai e Lin Feng. "Optimization of Nanoparticles for Smart Drug Delivery: A Review". Nanomaterials 11, n. 11 (21 ottobre 2021): 2790. http://dx.doi.org/10.3390/nano11112790.

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Nanoparticle delivery systems have good application prospects in the treatment of various diseases, especially in cancer treatment. The effect of drug delivery is regulated by the properties of nanoparticles. There have been many studies focusing on optimizing the structure of nanoparticles in recent years, and a series of achievements have been made. This review summarizes the optimization strategies of nanoparticles from three aspects—improving biocompatibility, increasing the targeting efficiency of nanoparticles, and improving the drug loading rate of nanoparticles—aiming to provide some theoretical reference for the subsequent drug delivery of nanoparticles.

2

Li, Tongtao, Kwok Hoe Chan, Tianpeng Ding, Xiao-Qiao Wang, Yin Cheng, Chen Zhang, Wanheng Lu, Gamze Yilmaz, Cheng-Wei Qiu e Ghim Wei Ho. "Dynamic thermal trapping enables cross-species smart nanoparticle swarms". Science Advances 7, n. 2 (gennaio 2021): eabe3184. http://dx.doi.org/10.1126/sciadv.abe3184.

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Bioinspired nano/microswarm enables fascinating collective controllability beyond the abilities of the constituent individuals, yet almost invariably, the composed units are of single species. Advancing such swarm technologies poses a grand challenge in synchronous mass manipulation of multimaterials that hold different physiochemical identities. Here, we present a dynamic thermal trapping strategy using thermoresponsive-based magnetic smart nanoparticles as host species to reversibly trap and couple given nonmagnetic entities in aqueous surroundings, enabling cross-species smart nanoparticle swarms (SMARS). Such trapping process endows unaddressable nonmagnetic species with efficient thermo-switchable magnetic response, which determines SMARS’ cross-species synchronized maneuverability. Benefiting from collective merits of hybrid components, SMARS can be configured into specific smart modules spanning from chain, vesicle, droplet, to ionic module, which can implement localized or distributed functions that are single-species unachievable. Our methodology allows dynamic multimaterials integration despite the odds of their intrinsic identities to conceive distinctive structures and functions.

3

Capek, Ignác. "Smart Biodecorated Hybrid Nanoparticles". Current Bionanotechnology 1, n. 1 (28 luglio 2015): 60–78. http://dx.doi.org/10.2174/2213529401666150630170400.

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4

Liu, Rihe, Brian K. Kay, Shaoyi Jiang e Shengfu Chen. "Nanoparticle Delivery: Targeting and Nonspecific Binding". MRS Bulletin 34, n. 6 (giugno 2009): 432–40. http://dx.doi.org/10.1557/mrs2009.119.

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AbstractTargeted cancer therapies focus on molecular and cellular changes that are specific to cancer and hold the promise of harming fewer normal cells, reducing side effects, and improving the quality of life. One major challenge in cancer nanotechnology is how to selectively deliver nanoparticles to diseased tissues while simultaneously minimizing the accumulation onto the nanoparticle of unwanted materials (e.g., proteins in the blood) during the delivery process. Once therapeutic nanoparticles have been created, very often they are linked or coated to other molecules that assist in targeting the delivery of nanoparticles to different cell types of the body. These linkers or coatings have been termed targeting ligands or “smart molecules” because of their inherent ability to direct selective binding to cell types or states and, therefore, confer “smartness” to nanoparticles. Likewise, “smartness” can be imparted to the nanoparticles to selectively repel unwanted entities in the body. To date, such smart molecules can consist of peptides, antibodies, engineered proteins, nucleic acid aptamers, or small organic molecules. This review describes how such smart molecules are discovered, enhanced, and anchored to nanoparticles, with an emphasis on how to minimize nonspecific interactions of nanoparticles to unintended targets.

5

Arif, Muhammad. "Catalytic degradation of azo dyes by bimetallic nanoparticles loaded in smart polymer microgels". RSC Advances 13, n. 5 (2023): 3008–19. http://dx.doi.org/10.1039/d2ra07932a.

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6

Kimura, Atsushi, Miho Ueno, Tadashi Arai, Kotaro Oyama e Mitsumasa Taguchi. "Radiation Crosslinked Smart Peptide Nanoparticles: A New Platform for Tumor Imaging". Nanomaterials 11, n. 3 (12 marzo 2021): 714. http://dx.doi.org/10.3390/nano11030714.

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Nanoparticles have been employed to develop nanosensors and drug carriers that accumulate in tumors. Thus, it is necessary to control the particle size, surface potential, and biodegradability of these nanoparticles for effective tumor accumulation and safe medical application. In this study, to form a nanoparticle platform suitable for diagnostic and drug delivery system (DDS) applications, peptides composed of aromatic amino acid residues were designed and synthesized based on the radiation crosslinking mechanism of proteins. The peptide nanoparticles, which were produced by γ-ray irradiation, displayed a positive surface potential, maintained biodegradability, and were stable in water and phosphoric buffer solution during actual diagnosis. The surface potential of the peptide nanoparticles could be changed to negative by using a fluorescent labeling reagent, so that the fluorescent-labeled peptide nanoparticles were uptaken by HeLa cells. The radiation-crosslinked nanoparticles can be applied as a platform for tumor-targeting diagnostics and DDS therapy.

7

Kong, Xiangqi, Yi Liu, Xueyan Huang, Shuai Huang, Feng Gao, Pengfei Rong, Shengwang Zhang, Kexiang Zhang e Wenbin Zeng. "Cancer Therapy Based on Smart Drug Delivery with Advanced Nanoparticles". Anti-Cancer Agents in Medicinal Chemistry 19, n. 6 (10 luglio 2019): 720–30. http://dx.doi.org/10.2174/1871520619666190212124944.

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Background: Cancer, as one of the most dangerous disease, causes millions of deaths every year. The main reason is the absence of an effective and thorough treatment. Drug delivery systems have significantly reduced the side-effect of chemotherapy. Combined with nanotechnology, smart drug delivery systems including many different nanoparticles can reduce the side-effect of chemotherapy better than traditional drug delivery systems. Methods: In this article, we will describe in detail the different kinds of nanoparticles and their mechanisms emphasizing the triggering factors in drug delivery. Besides, the application of smart drug delivery systems in imaging will be introduced. Results: Combined with nanotechnology, smart drug delivery systems including many different nanoparticles can reduce the side-effect of chemotherapy better than traditional drug delivery systems. Conclusion: Despite considerable progress in nanoparticle research over the past decade, such as smart drug delivery systems for the treatment of cancer, molecular imaging probes and the like. The range of nanoparticles used in multifunction systems for imaging and drug delivery continues to grow and we expect this dilatation to continue. But to make nanoparticles truly a series of clinical products to complement and replace current tools, constant exploration efforts and time are required. Overall, the future looks really bright.

8

Gulia, Khushabu, Abija James, Sadanand Pandey, Kamal Dev, Deepak Kumar e Anuradha Sourirajan. "Bio-Inspired Smart Nanoparticles in Enhanced Cancer Theranostics and Targeted Drug Delivery". Journal of Functional Biomaterials 13, n. 4 (28 ottobre 2022): 207. http://dx.doi.org/10.3390/jfb13040207.

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Globally, a significant portion of deaths are caused by cancer.Compared with traditional treatment, nanotechnology offers new therapeutic options for cancer due to its ability to selectively target and control drug release. Among the various routes of nanoparticle synthesis, plants have gained significant recognition. The tremendous potential of medicinal plants in anticancer treatments calls for a comprehensive review of existing studies on plant-based nanoparticles. The study examined various metallic nanoparticles obtained by green synthesis using medicinal plants. Plants contain biomolecules, secondary metabolites, and coenzymes that facilitate the reduction of metal ions into nanoparticles. These nanoparticles are believed to be potential antioxidants and cancer-fighting agents. This review aims at the futuristic intuitions of biosynthesis and applications of plant-based nanoparticles in cancer theranostics.

9

Tolle, Christian, Jan Riedel, Carina Mikolai, Andreas Winkel, Meike Stiesch, Dagmar Wirth e Henning Menzel. "Biocompatible Coatings from Smart Biopolymer Nanoparticles for Enzymatically Induced Drug Release". Biomolecules 8, n. 4 (28 settembre 2018): 103. http://dx.doi.org/10.3390/biom8040103.

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Nanoparticles can be used as a smart drug delivery system, when they release the drug only upon degradation by specific enzymes. A method to create such responsive materials is the formation of hydrogel nanoparticles, which have enzymatically degradable crosslinkers. Such hydrogel nanoparticles were prepared by ionotropic gelation sodium alginate with lysine-rich peptide sequences—either α-poly-L-lysine (PLL) or the aggrecanase-labile sequence KKKK-GRD-ARGSV↓NITEGE-DRG-KKKK. The nanoparticle suspensions obtained were analyzed by means of dynamic light scattering and nanoparticle tracking analysis. Degradation experiments carried out with the nanoparticles in suspension revealed enzyme-induced lability. Drugs present in the polymer solution during the ionotropic gelation can be encapsulated in the nanoparticles. Drug loading was investigated for interferon- (IFN-) as a model, using a bioluminescence assay with MX2Luc2 cells. The encapsulation efficiency for IFN- was found to be approximately 25%. The nanoparticles suspension can be used to spray-coat titanium alloys (Ti-6Al-4V) as a common implant material. The coatings were proven by ellipsometry, reflection-absorption infrared spectroscopy, and X-ray photoelectron spectroscopy. An enzyme-responsive decrease in layer thickness is observed due to the degradation of the coatings. The Alg/peptide coatings were cytocompatible for human gingival fibroblasts (HGFIB), which was investigated by CellTiterBlue and lactate dehydrogenase (LDH) assay. However, HGFIBs showed poor adhesion and proliferation on the Alg/peptide coatings, but these could be improved by modification of the alginate with a RGD-peptide sequence. The smart drug release system presented can be further tailored to have the right release kinetics and cell adhesion properties.

10

Friedman, Adam, Sarah Claypool e Rihe Liu. "The Smart Targeting of Nanoparticles". Current Pharmaceutical Design 19, n. 35 (1 settembre 2013): 6315–29. http://dx.doi.org/10.2174/13816128113199990375.

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Ou, Yu-Chuan, Xiaona Wen e Rizia Bardhan. "Cancer Immunoimaging with Smart Nanoparticles". Trends in Biotechnology 38, n. 4 (aprile 2020): 388–403. http://dx.doi.org/10.1016/j.tibtech.2019.11.001.

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Chakraborty, Dr. "Nanoparticles as smart pharmaceutical delivery". Frontiers in Bioscience 18, n. 3 (2013): 1030. http://dx.doi.org/10.2741/4161.

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Nakayama, Yoshitaka, Mislav Mustapić, Haleh Ebrahimian, Pawel Wagner, Jung Ho Kim, Md Shahriar Al Hossain, Joseph Horvat e Boris Martinac. "Magnetic nanoparticles for “smart liposomes”". European Biophysics Journal 44, n. 8 (17 luglio 2015): 647–54. http://dx.doi.org/10.1007/s00249-015-1059-0.

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Arif, Muhammad. "A Critical Review of Palladium Nanoparticles Decorated in Smart Microgels". Polymers 15, n. 17 (30 agosto 2023): 3600. http://dx.doi.org/10.3390/polym15173600.

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Palladium nanoparticles (Pd) combined with smart polymer microgels have attracted significant interest in the past decade. These hybrid materials have unique properties that make them appealing for various applications in biology, environmental remediation, and catalysis. The responsive nature of the microgels in these hybrids holds great promise for a wide range of applications. The literature contains diverse morphologies and architectures of Pd nanoparticle-based hybrid microgels, and the architecture of these hybrids plays a vital role in determining their potential uses. Therefore, specific Pd nanoparticle-based hybrid microgels are designed for specific applications. This report provides an overview of recent advancements in the classification, synthesis, properties, characterization, and uses of Pd nanostructures loaded into microgels. Additionally, the report discusses the latest progress in biomedical, catalytic, environmental, and sensing applications of Pd-based hybrid microgels in a tutorial manner.

15

Khdary, Nezar H. "Determination of Ultra-Trace of Herbicides Using Smart Nanoparticles". Advanced Materials Research 699 (maggio 2013): 144–49. http://dx.doi.org/10.4028/www.scientific.net/amr.699.144.

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18- Smart Nanoparticles was synthesized using sol-gel process. The spherical particles were obtained using appropriate parameters such as solvent. Modification of C18-Smart Nanoparticles was carried out using trichloro and trimethoxy octadecylsilane. The modified particles were designed for extraction and preconcentration of herbicides as illustrated in figure 1. Herbicides molecules were easily recognized by C18- Smart Nanoparticles and the recoveries were varied from 59-82%.

16

Kwon, Ester J., Justin H. Lo e Sangeeta N. Bhatia. "Smart nanosystems: Bio-inspired technologies that interact with the host environment". Proceedings of the National Academy of Sciences 112, n. 47 (23 novembre 2015): 14460–66. http://dx.doi.org/10.1073/pnas.1508522112.

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Nanoparticle technologies intended for human administration must be designed to interact with, and ideally leverage, a living host environment. Here, we describe smart nanosystems classified in two categories: (i) those that sense the host environment and respond and (ii) those that first prime the host environment to interact with engineered nanoparticles. Smart nanosystems have the potential to produce personalized diagnostic and therapeutic schema by using the local environment to drive material behavior and ultimately improve human health.

17

Martins, A. J., M. Benelmekki, V. Teixeira e P. J. G. Coutinho. "Platinum Nanoparticles as pH Sensor for Intelligent Packaging". Journal of Nano Research 18-19 (luglio 2012): 97–104. http://dx.doi.org/10.4028/www.scientific.net/jnanor.18-19.97.

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Pt nanoparticles were produced by reverse micelle templating using DTAB. The resulting nanoparticles showed sizes between 250nm and 500nm and formed clusters. Thioglycolic acid (TGA) was covalently attached to the nanoparticle surface as a stabilizer and as. The Pt nanoparticles were dispersed in water and the dependence of its absorvance on the pH of the solution was studied. The spectra showed surface plamon absorption band at 280nm and also red shifted bands that were attributed to clusters of nanoparticles. It was found that the fraction of cluster population depends on the pH of the aqueous solution and that the response of the Pt nanoparticles to pH variations has a memory effect (hysteresis). The possibility of using these Pt nanoparticles in smart labels for food packaging is outlined.

18

Yeganeh, Faten Eshrati, Amir Eshrati Yeganeh, Bahareh Farasati Far, Afsoun Mansouri, Belay Zeleke Sibuh, Saravanan Krishnan, Soumya Pandit, Walaa F. Alsanie, Vijay Kumar Thakur e Piyush Kumar Gupta. "Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe2O4 Nanoparticles for Anticancer and Antibacterial Applications". Nanomaterials 12, n. 13 (3 luglio 2022): 2286. http://dx.doi.org/10.3390/nano12132286.

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In the present study, nickel ferrite (NiFe2O4)-based smart magnetic nanoparticles were fabricated and coated with methionine. Physiochemical characterization of the obtained Met-NiFe2O4 nanoparticles revealed the presence of methionine coating over the nanoparticle surface. Drug release study indicated that Tet-Met-NiFe2O4 nanoparticles possess pH-responsive controlled drug release behavior for tetracycline (Tet). The drug loading content for Tet was found to be 0.27 mg/L of nanoparticles. In vitro cytotoxicity test showed that the Met-NiFe2O4 nanoparticles is biocompatible. Moreover, this magnetic nanostructured material shown strong anticancer property as these nanomaterials significantly reduced the viability of A375 cells when compared to free Tet solution. In addition, Tet-Met-NiFe2O4 nanoparticles also showed strong antibacterial activity against different bacterial pathogens.

19

Ballauff, Matthias, e Yan Lu. "“Smart” nanoparticles: Preparation, characterization and applications". Polymer 48, n. 7 (marzo 2007): 1815–23. http://dx.doi.org/10.1016/j.polymer.2007.02.004.

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Alves, Sérgio, Catarina Santos, André P. da Costa, Mara Silva, Carlos Baleizão e José Paulo S. Farinha. "Smart polymeric nanoparticles for boron scavenging". Chemical Engineering Journal 319 (luglio 2017): 31–38. http://dx.doi.org/10.1016/j.cej.2017.02.139.

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Yu, Zhecheng, Xingyue Shen, Han Yu, Haohong Tu, Chuda Chittasupho e Yunqi Zhao. "Smart Polymeric Nanoparticles in Cancer Immunotherapy". Pharmaceutics 15, n. 3 (26 febbraio 2023): 775. http://dx.doi.org/10.3390/pharmaceutics15030775.

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Cancer develops with unexpected mutations and causes death in many patients. Among the different cancer treatment strategies, immunotherapy is promising with the benefits of high specificity and accuracy, as well as modulating immune responses. Nanomaterials can be used to formulate drug delivery carriers for targeted cancer therapy. Polymeric nanoparticles used in the clinic are biocompatible and have excellent stability. They have the potential to improve therapeutic effects while significantly reducing off-target toxicity. This review classifies smart drug delivery systems based on their components. Synthetic smart polymers used in the pharmaceutical industry, including enzyme-responsive, pH-responsive, and redox-responsive polymers, are discussed. Natural polymers derived from plants, animals, microbes, and marine organisms can also be used to construct stimuli-responsive delivery systems with excellent biocompatibility, low toxicity, and biodegradability. The applications of smart or stimuli-responsive polymers in cancer immunotherapies are discussed in this systemic review. We summarize different delivery strategies and mechanisms that can be used in cancer immunotherapy and give examples of each case.

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Torres-Lopez, Ernesto, Nora Elizondo, Luz H. Verastegui, Jose J. Quijano, Rosa María Estrada-Martinez, Celia Mendiburu e Víctor M. Castaño. "Smart Antibody-Conjugated Gold Nanoparticles for Bioengineered Polymers". Science of Advanced Materials 13, n. 2 (1 febbraio 2021): 217–21. http://dx.doi.org/10.1166/sam.2021.3887.

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Au and Ag nanoparticles (NP) were synthesized using a green method that allows control of both particle size and surface chemistry. The gold and silver nanoparticles were coated with a fluorescent goat anti-body IgG that chemically incorporated the nanoparticles and the internalization behavior was studied by phagocytosis in murine peritoneal macrophages. Despite that, in principle, the presence of a simple metal induces a greater degree of cell death following the particle uptake, our results suggest that a large part of the silver and gold nanoparticles enter cells by means other than endocytosis and phagocytosis, as truly intelligent nanoparticles. This represents a potential for immunotherapy and studies to modulate the innate immune response as truly smart nanoparticles.

23

Vasiliu, Silvia, Stefania Racovita, Ionela Aurica Gugoasa, Maria-Andreea Lungan, Marcel Popa e Jacques Desbrieres. "The Benefits of Smart Nanoparticles in Dental Applications". International Journal of Molecular Sciences 22, n. 5 (4 marzo 2021): 2585. http://dx.doi.org/10.3390/ijms22052585.

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Dentistry, as a branch of medicine, has undergone continuous evolution over time. The scientific world has focused its attention on the development of new methods and materials with improved properties that meet the needs of patients. For this purpose, the replacement of so-called “passive” dental materials that do not interact with the oral environment with “smart/intelligent” materials that have the capability to change their shape, color, or size in response to an externally stimulus, such as the temperature, pH, light, moisture, stress, electric or magnetic fields, and chemical compounds, has received much attention in recent years. A strong trend in dental applications is to apply nanotechnology and smart nanomaterials such as nanoclays, nanofibers, nanocomposites, nanobubbles, nanocapsules, solid-lipid nanoparticles, nanospheres, metallic nanoparticles, nanotubes, and nanocrystals. Among the nanomaterials, the smart nanoparticles present several advantages compared to other materials, creating the possibility to use them in various dental applications, including preventive dentistry, endodontics, restoration, and periodontal diseases. This review is focused on the recent developments and dental applications (drug delivery systems and restoration materials) of smart nanoparticles.

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Gschwend, Grégoire C., Evgeny Smirnov, Pekka Peljo e Hubert H. Girault. "Electrovariable gold nanoparticle films at liquid–liquid interfaces: from redox electrocatalysis to Marangoni-shutters". Faraday Discussions 199 (2017): 565–83. http://dx.doi.org/10.1039/c6fd00238b.

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Control over the physical properties of nanoparticle assemblies at a liquid–liquid interface is a key technological advancement to realize the dream of smart electrovariable nanosystems. Electrified interfaces, such as the interface between two immiscible electrolytes solutions (ITIES), are almost an ideal platform for realizing this dream. Here, we show that the Galvani potential difference across soft interfaces can be effectively used to manipulate: (i) the reactivity of gold nanoparticle assemblies through varying the Fermi level (both chemically and electrochemically); (ii) the location distribution of the nanoparticles at the liquid–liquid interface. In the first case, in addition to our previous studies on electron transfer reactions (ET) across the ITIES, we used intensity modulated photocurrent spectroscopy (IMPS) to study the kinetics of photo-induced electrochemical reactions at the ITIES. As expected, the direct adsorption of gold nanoparticles at the interface modifies the kinetics of the ET reaction (so-called, interfacial redox electrocatalysis), however it did not lead to an increased photocurrent by “plasmonic enhancement”. Rather, we found that the product separation depends on double layer effects while the product recombination is controlled by the Galvani potential difference between the two phases. In the second case, we demonstrated that polarizing the ITIES caused migration of gold nanoparticles from the middle region of the cell to its periphery. We called such systems “Marangoni-type shutters”. This type of electrovariable plasmonic system did not experience diffusion limitation in terms of the adsorption/desorption of nanoparticles and the entire movement of nanoparticle assemblies happened almost instantly (within a second). It opens a fresh view on electrovariable plasmonics and presents new opportunities to create smart nanosystems at the ITIES driven with an electric field.

25

Chugh, Gaurav, Kadambot H. M. Siddique e Zakaria M. Solaiman. "Nanobiotechnology for Agriculture: Smart Technology for Combating Nutrient Deficiencies with Nanotoxicity Challenges". Sustainability 13, n. 4 (7 febbraio 2021): 1781. http://dx.doi.org/10.3390/su13041781.

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Nanobiotechnology in agriculture is a driver for modern-day smart, efficient agricultural practices. Nanoparticles have been shown to stimulate plant growth and disease resistance. The goal of sustainable farming can be accomplished by developing and sustainably exploiting the fruits of nanobiotechnology to balance the advantages nanotechnology provides in tackling environmental challenges. This review aims to advance our understanding of nanobiotechnology in relevant areas, encourage interactions within the research community for broader application, and benefit society through innovation to realize sustainable agricultural practices. This review critically evaluates what is and is not known in the domain of nano-enabled agriculture. It provides a holistic view of the role of nanobiotechnology in multiple facets of agriculture, from the synthesis of nanoparticles to controlled and targeted delivery, uptake, translocation, recognition, interaction with plant cells, and the toxicity potential of nanoparticle complexes when presented to plant cells.

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Yin, Shu, Anung Riapanitra e Yusuke Asakura. "Nanomaterials for infrared shielding smart coatings". Functional Materials Letters 11, n. 05 (ottobre 2018): 1830004. http://dx.doi.org/10.1142/s1793604718300049.

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Synthesis and characterization of functional nanoparticles and their applications for smart window are reviewed. Various kinds of nanomaterials and their composites are successfully synthesized by solvothermal process. Thin films on glass substrate can be fabricated by doctor blade method using nanoparticles as starting materials. The mixed valence state tungsten-based homogeneous nanomaterials possess excellent infrared (IR) light shielding properties, implying their potential applications for the heat ray shielding and indoor energy saving effect in summer. On the other hand, VO2 monoclinic-based nanoparticles possess smart and excellent thermochromic properties, show excellent heat ray shielding effect in summer and heating effect of winter indoors. Also, multifunctionality of thin films can be realized by fabricating the composites with various functional components, implying their potential applications for IR shielding, photocatalysis and self-cleaning at the same time. The design of composites and structure of thin films might result in the enhancement or properties of practice applications on window materials.

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van Rijt, Sabine, e Pamela Habibovic. "Enhancing regenerative approaches with nanoparticles". Journal of The Royal Society Interface 14, n. 129 (aprile 2017): 20170093. http://dx.doi.org/10.1098/rsif.2017.0093.

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In this review, we discuss recent developments in the field of nanoparticles and their use in tissue regeneration approaches. Owing to their unique chemical properties and flexibility in design, nanoparticles can be used as drug delivery systems, to create novel features within materials or as bioimaging agents, or indeed these properties can be combined to create smart multifunctional structures. This review aims to provide an overview of this research field where the focus will be on nanoparticle-based strategies to stimulate bone regeneration; however, the same principles can be applied for other tissue and organ regeneration strategies. In the first section, nanoparticle-based methods for the delivery of drugs, growth factors and genetic material to promote tissue regeneration are discussed. The second section deals with the addition of nanoparticles to materials to create nanocomposites. Such materials can improve several material properties, including mechanical stability, biocompatibility and biological activity. The third section will deal with the emergence of a relatively new field of research using nanoparticles in advanced cell imaging and stem cell tracking approaches. As the development of nanoparticles continues, incorporation of this technology in the field of regenerative medicine will ultimately lead to new tools that can diagnose, track and stimulate the growth of new tissues and organs.

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Baleizão, Carlos, e José Paulo S. Farinha. "Hybrid smart mesoporous silica nanoparticles for theranostics". Nanomedicine 10, n. 15 (agosto 2015): 2311–14. http://dx.doi.org/10.2217/nnm.15.102.

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Ozalp, Veli Cengiz, Fusun Eyidogan e Huseyin Avni Oktem. "Aptamer-Gated Nanoparticles for Smart Drug Delivery". Pharmaceuticals 4, n. 8 (15 agosto 2011): 1137–57. http://dx.doi.org/10.3390/ph4081137.

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Chen, Jinjin, Zhongyu Jiang, Yu Shrike Zhang, Jianxun Ding e Xuesi Chen. "Smart transformable nanoparticles for enhanced tumor theranostics". Applied Physics Reviews 8, n. 4 (dicembre 2021): 041321. http://dx.doi.org/10.1063/5.0061530.

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Shrestha, Binita, Lijun Wang, Eric M. Brey, Gabriela Romero Uribe e Liang Tang. "Smart Nanoparticles for Chemo-Based Combinational Therapy". Pharmaceutics 13, n. 6 (8 giugno 2021): 853. http://dx.doi.org/10.3390/pharmaceutics13060853.

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Cancer is a heterogeneous and complex disease. Traditional cancer therapy is associated with low therapeutic index, acquired resistance, and various adverse effects. With the increasing understanding of cancer biology and technology advancements, more strategies have been exploited to optimize the therapeutic outcomes. The rapid development and application of nanomedicine have motivated this progress. Combinational regimen, for instance, has become an indispensable approach for effective cancer treatment, including the combination of chemotherapeutic agents, chemo-energy, chemo-gene, chemo-small molecules, and chemo-immunology. Additionally, smart nanoplatforms that respond to external stimuli (such as light, temperature, ultrasound, and magnetic field), and/or to internal stimuli (such as changes in pH, enzymes, hypoxia, and redox) have been extensively investigated to improve precision therapy. Smart nanoplatforms for combinational therapy have demonstrated the potential to be the next generation cancer treatment regimen. This review aims to highlight the recent advances in smart combinational therapy.

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Yang, Eun-Jeong, Jiyoung Jang, Seungjae Kim e In-Hong Choi. "Silver Nanoparticles as a Smart Antimicrobial Agent". Journal of Bacteriology and Virology 42, n. 2 (2012): 177. http://dx.doi.org/10.4167/jbv.2012.42.2.177.

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Li, Jun, Anantha-Iyengar Gopalan e Kwang-Pill Lee. "Synthesis of Magnetic Nanoparticles Incorporated Smart Gel". Journal of Nanoscience and Nanotechnology 15, n. 9 (1 settembre 2015): 7202–10. http://dx.doi.org/10.1166/jnn.2015.10568.

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Gref, R., e D. Duchêne. "Cyclodextrins as “smart” components of polymer nanoparticles". Journal of Drug Delivery Science and Technology 22, n. 3 (2012): 223–33. http://dx.doi.org/10.1016/s1773-2247(12)50033-x.

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Liu, Hai-Jun, e Peisheng Xu. "Smart Mesoporous Silica Nanoparticles for Protein Delivery". Nanomaterials 9, n. 4 (2 aprile 2019): 511. http://dx.doi.org/10.3390/nano9040511.

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Abstract (sommario):

Mesoporous silica nanoparticles (MSN) have attracted a lot of attention during the past decade which is attributable to their versatile and high loading capacity, easy surface functionalization, excellent biocompatibility, and great physicochemical and thermal stability. In this review, we discuss the factors affecting the loading of protein into MSN and general strategies for targeted delivery and controlled release of proteins with MSN. Additionally, we also give an outlook for the remaining challenges in the clinical translation of protein-loaded MSNs.

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Lin, Guimei, Hong Zhang e Leaf Huang. "Smart Polymeric Nanoparticles for Cancer Gene Delivery". Molecular Pharmaceutics 12, n. 2 (7 gennaio 2015): 314–21. http://dx.doi.org/10.1021/mp500656v.

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Iuliano, Mariagrazia, Claudia Cirillo, Francesca Fierro, Claudia Florio, Gaetano Maffei, Andrea Loi, Todor Batakliev, Renata Adami e Maria Sarno. "Titania nanoparticles finishing for smart leather surface". Progress in Organic Coatings 192 (luglio 2024): 108457. http://dx.doi.org/10.1016/j.porgcoat.2024.108457.

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Аntonova, Оlga Yu, Olga Yu Коchetkova e Igor L. Kanev. "Light-to-Heat Converting ECM-Mimetic Nanofiber Scaffolds for Neuronal Differentiation and Neurite Outgrowth Guidance". Nanomaterials 12, n. 13 (23 giugno 2022): 2166. http://dx.doi.org/10.3390/nano12132166.

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The topological cues of fibrous scaffolds (in particular extracellular matrix (ECM)-mimetic nanofibers) have already proven to be a powerful tool for influencing neuronal morphology and behavior. Remote photothermal optical treatment provides additional opportunities for neuronal activity regulation. A combination of these approaches can provide “smart” 3D scaffolds for efficient axon guidance and neurite growth. In this study we propose two alternative approaches for obtaining biocompatible photothermal scaffolds: surface coating of nylon nanofibers with light-to-heat converting nanoparticles and nanoparticle incorporation inside the fibers. We have determined photoconversion efficiency of fibrous nanomaterials under near infrared (NIR) irradiation, as well as biocompatible photothermal treatment parameters. We also measured photo-induced intracellular heating upon contact of cells with a plasmonic surface. In the absence of NIR stimulation, our fibrous scaffolds with a fiber diameter of 100 nm induced an increase in the proportion of β3-tubulin positive cells, while thermal stimulation of neuroblastoma cells on nanoparticles-decorated scaffolds enhanced neurite outgrowth and promoted neuronal maturation. We demonstrate that contact guidance decorated fibers can stimulate directional growth of processes of differentiated neural cells. We studied the impact of nanoparticles on the surface of ECM-mimetic scaffolds on neurite elongation and axonal branching of rat hippocampal neurons, both as topographic cues and as local heat sources. We show that decorating the surface of nanofibers with nanoparticles does not affect the orientation of neurites, but leads to strong branching, an increase in the number of neurites per cell, and neurite elongation, which is independent of NIR stimulation. The effect of photothermal stimulation is most pronounced when cultivating neurons on nanofibers with incorporated nanoparticles, as compared to nanoparticle-coated fibers. The resulting light-to-heat converting 3D materials can be used as tools for controlled photothermal neuromodulation and as “smart” materials for reconstructive neurosurgery.

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Jingen, Deng, Saviour Bassey Egwu e Zhao Xionghu. "Smart Fluids and Their Applications in Drilling Fluids to Meet Drilling Technical Challenges". Advances in Materials Science and Engineering 2022 (4 ottobre 2022): 1–12. http://dx.doi.org/10.1155/2022/2335406.

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This article presents extensive analysis and review on recent developments in smart fluids as well as future opportunities of smart drilling fluids utilization in oil and gas well drilling while focusing on the following smart fluids: smart nanoparticles, electrorheological, magnetorheological, and viscoelastic surfactant (VES) fluids. The distinctive properties of nanoparticles such as tiny particle sizes, high specific surface area, mechanical strength, and thermal stability make them suitable for utilization in drilling fluids. In bentonite water-based drilling fluid systems, this review suggests that charged nanoparticles are capable of displacing exchangeable ions in between bentonite clay platelets, thereby forming intercalates which can interact with clay surfaces through electrostatic attraction or repulsion. In improving wellbore stability, it is presented in this review that nanoparticles are able to invade and plug ultratiny pore spaces in shale formations, thereby further enhancing shale formations’ mechanical strength and wellbore stability. According to this review, the magnitude of changes in properties of smart electrorheological and magnetorheological fluids largely depends on the intensity of applied electric and magnetic fields. The intensity of smart fluids properties alteration due to applied field would equally depend on wt.% concentration and chemical compositions of particles susceptible to electric and magnetic fields. Based on review carried out on VES smart fluids, attractive and repulsive forces in the smart VES fluids solution result in the formation of micelles which can cause changes in viscoelastic property of the formulated smart viscoelastic fluids. The more the concentration of charged ions in the base fluid which VES fluids come in contact with, the higher the viscoelasticity of the smart VES fluids. According to this review, utilization of smart materials in drilling fluids can result in meeting oil and gas well drilling technical challenges including enhancing wellbore stability, improving hole cleaning performance, lost circulation control, fluid loss control, enhancing rate of penetration, pressure drop control, and easing cutting carrying efficiency of drilling fluids. This review equally suggests that the utilization of smart fluids such as smart magnetorheological and electrorheological fluids would facilitate drilling automation and real-time data acquisition processes, which is the future technology in oil and gas drilling.

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Lin, Xiaoying, Feng Wu, Yunqing He e Mingxian Liu. "Flexible and Wearable Strain–Temperature Sensors Based on Chitosan/Ink Sponges". Molecules 28, n. 10 (14 maggio 2023): 4083. http://dx.doi.org/10.3390/molecules28104083.

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A simple and economic strategy to construct a chitosan-ink carbon nanoparticle sponge sensor was proposed by freeze-drying of chitosan and Chinese ink mixture solution. The microstructure and physical properties of the composite sponges with different ratios are characterized. The interfacial compatibility of chitosan and carbon nanoparticles in ink is satisfied, and the mechanical property and porosity of chitosan was increased by the incorporation of carbon nanoparticles. Due to excellent conductivity and good photothermal conversion effect of the carbon nanoparticles in ink, the constructed flexible sponge sensor has satisfactory strain and temperature sensing performance and high sensitivity (133.05 ms). In addition, these sensors can be successfully applied to monitor the large joint movement of the human body and the movement of muscle groups near the esophagus. Dual functionally integrated sponge sensors show great potential for strain and temperature detection in real time. The prepared chitosan-ink carbon nanoparticle composite shows promising applications in wearable smart sensors.

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Adhikary, Rishi Rajat, Prachi More e Rinti Banerjee. "Smart nanoparticles as targeting platforms for HIV infections". Nanoscale 7, n. 17 (2015): 7520–34. http://dx.doi.org/10.1039/c5nr01285f.

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Ata, Sadia, Anila Tabassum, Ismat Bibi, Farzana Majid, Misbah Sultan, Samina Ghafoor, Muhammad Arif Bhatti, Naseem Qureshi e Munawar Iqbal. "Lead Remediation Using Smart Materials. A Review". Zeitschrift für Physikalische Chemie 233, n. 10 (25 ottobre 2019): 1377–409. http://dx.doi.org/10.1515/zpch-2018-1205.

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Abstract The nanoparticles have been prepared and employed as excellent adsorbents for the sequestration of heavy metal ions and hazardous impurities from the aqueous media. The surface morphological, textural and structural properties of nanoparticles have been modified, which are capable and potentially useful for the remediation of metal ions. Several metals (oxides, doped, nanocomposites of Fe, Ti, Zn, SiO2, SiC, Mo, Co, Ni, Zr, Mn, Si, S, Al, Cu, Ce, graphene, CNTs) were reported an efficient adsorbents for the removal of lead (Pb) ions from aqueous media and polluted water. The present review focuses on different kinds of nanoparticles such as metal oxides, carbon based and host supported employed for removal of Pb ions under varying experimental conditions such as pH, temperature, contact time and concentrations. The preparation strategies, physicochemical properties and adsorption are also discussed. Based on studies, it was found that the smart materials are affective adsorbents for the purification of wastewater containing Pb ions and could possibly extended for the remediation of other heavy metal ions.

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Suvarli, Narmin, Max Frentzel, Jürgen Hubbuch, Iris Perner-Nochta e Michael Wörner. "Synthesis of Spherical Nanoparticle Hybrids via Aerosol Thiol-Ene Photopolymerization and Their Bioconjugation". Nanomaterials 12, n. 3 (8 febbraio 2022): 577. http://dx.doi.org/10.3390/nano12030577.

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Hybrid nanomaterials possess the properties of both organic and inorganic components and find applications in various fields of research and technology. In this study, aerosol photopolymerization is used in combination with thiol-ene chemistry to produce silver poly(thio-ether) hybrid nanospheres. In aerosol photopolymerization, a spray solution of monomers is atomized, forming a droplet aerosol, which then polymerizes, producing spherical polymer nanoparticles. To produce silver poly(thio-ether) hybrids, silver nanoparticles were introduced to the spray solution. Diverse methods of stabilization were used to produce stable dispersions of silver nanoparticles to prevent their agglomeration before the photopolymerization process. Successfully stabilized silver nanoparticle dispersion in the spray solution subsequently formed nanocomposites with non-agglomerated silver nanoparticles inside the polymer matrix. Nanocomposite particles were analyzed via scanning and transmission electron microscopy to study the degree of agglomeration of silver nanoparticles and their location inside the polymer spheres. The nanoparticle hybrids were then introduced onto various biofunctionalization reactions. A two-step bioconjugation process was developed involving the hybrid nanoparticles: (1) conjugation of (biotin)-maleimide to thiol-groups on the polymer network of the hybrids, and (2) biotin-streptavidin binding. The biofunctionalization with gold-nanoparticle-conjugates was carried out to confirm the reactivity of -SH groups on each conjugation step. Fluorescence-labeled biomolecules were conjugated to the spherical nanoparticle hybrids (applying the two-step bioconjugation process) verified by Fluorescence Spectroscopy and Fluorescence Microscopy. The presented research offers an effective method of synthesis of smart systems that can further be used in biosensors and various other biomedical applications.

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Xu, Ruijie. "Feasible construction of a pH-responsive nanoparticle for smart drug delivery". Highlights in Science, Engineering and Technology 69 (6 novembre 2023): 463–69. http://dx.doi.org/10.54097/hset.v69i.12220.

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Endosomal pH-responsive micellar nanoparticles have been prepared by amphiphilic poly (ethylene glycol)-Schiff base-Adriamycin (PEG-Schiff-DOX，PSD) prodrug, and wrapped DOX drugs in the hydrophobic core of the polymeric nanoparticles. Under normal conditions, these nanoparticles showed good stability over a storage period of 7 days but decomposed rapidly under the weakly acidic conditions. These nanoparticles possessed a high drug loading capacity and good cell compatibility that would be promising for the drug carries in the drug delivery system.

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Włodarczyk, Agnieszka, Szymon Gorgoń, Adrian Radoń e Karolina Bajdak-Rusinek. "Magnetite Nanoparticles in Magnetic Hyperthermia and Cancer Therapies: Challenges and Perspectives". Nanomaterials 12, n. 11 (25 maggio 2022): 1807. http://dx.doi.org/10.3390/nano12111807.

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Until now, strategies used to treat cancer are imperfect, and this generates the need to search for better and safer solutions. The biggest issue is the lack of selective interaction with neoplastic cells, which is associated with occurrence of side effects and significantly reduces the effectiveness of therapies. The use of nanoparticles in cancer can counteract these problems. One of the most promising nanoparticles is magnetite. Implementation of this nanoparticle can improve various treatment methods such as hyperthermia, targeted drug delivery, cancer genotherapy, and protein therapy. In the first case, its feature makes magnetite useful in magnetic hyperthermia. Interaction of magnetite with the altered magnetic field generates heat. This process results in raised temperature only in a desired part of a patient body. In other therapies, magnetite-based nanoparticles could serve as a carrier for various types of therapeutic load. The magnetic field would direct the drug-related magnetite nanoparticles to the pathological site. Therefore, this material can be used in protein and gene therapy or drug delivery. Since the magnetite nanoparticle can be used in various types of cancer treatment, they are extensively studied. Herein, we summarize the latest finding on the applicability of the magnetite nanoparticles, also addressing the most critical problems faced by smart nanomedicine in oncological therapies.

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Ishihara, Kazuhiko, Wei Xin Chen e Yuuki Inoue. "Bioinspired and Multifunctional Phospholipid Polymer Nanoparticles". Advances in Science and Technology 102 (ottobre 2016): 3–11. http://dx.doi.org/10.4028/www.scientific.net/ast.102.3.

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Photoreactive and cytocompatible polymer nanoparticles for immobilizing and photoinduced releasing proteins were prepared. A water-soluble and amphiphilic phospholipid polymer, poly (2-methacryloyloxyethyl phosphorylcholine (MPC)-co-n-butyl methacrylate (BMA)-co-4-(4-(1-methacryloyloxyethyl)-2-methoxy-5-nitrophenoxy) butyric acid (PL)) (PMB-PL) was synthesized. The PMB-PL underwent a cleavage reaction at the PL unit by photoirradiation at a wavelength of 365 nm. Additionally, the PMB-PL took polymer aggregate in aqueous medium and was used to modify the surface of biodegradable poly (L-lactic acid) (PLA) nanoparticle as an emulsifier. The morphology of the PMB-PL/PLA nanoparticle was spherical and approximately 130 nm in diameter. The carboxylic acid group in the PL unit could be used for immobilization of proteins by covalent bonding. The bound proteins were released by a photoinduced cleavage reaction. Within 60 sec, up to 90% of the immobilized proteins were released by photoirradiation and activity of the protein released in the medium was maintained as well as that the original proteins before immobilization. Octa-arginine (R8) could promote internalization of the protein/PLA/PMB-PL nanoparticles into cells when the R8 was co-immobilized on the nanoparticles. After that, photoirradiation induced protein release from the nanoparticles and proteins distributed more evenly inside cells. From these results, we concluded that PMB-PL/PLA nanoparticles have the potential to be used as smart carriers to deliver proteins to biological systems, such as the inside of living cells.

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Park, Dongjin, Youngnam Cho, Sung-Ho Goh e Yongdoo Choi. "Hyaluronic acid–polypyrrole nanoparticles as pH-responsive theranostics". Chem. Commun. 50, n. 95 (2014): 15014–17. http://dx.doi.org/10.1039/c4cc06349j.

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Bongiovanni Abel, Silvestre, María A. Molina, Claudia R. Rivarola, Marcelo J. Kogan e Cesar A. Barbero. "Smart polyaniline nanoparticles with thermal and photothermal sensitivity". Nanotechnology 25, n. 49 (19 novembre 2014): 495602. http://dx.doi.org/10.1088/0957-4484/25/49/495602.

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Brändel, Timo, Viktor Sabadasch, Yvonne Hannappel e Thomas Hellweg. "Improved Smart Microgel Carriers for Catalytic Silver Nanoparticles". ACS Omega 4, n. 3 (4 marzo 2019): 4636–49. http://dx.doi.org/10.1021/acsomega.8b03511.

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Soleimani, Mohsen, Jeffrey C. Haley, Daniel Majonis, Gerald Guerin, Willie Lau e Mitchell A. Winnik. "Smart Polymer Nanoparticles Designed for Environmentally Compliant Coatings". Journal of the American Chemical Society 133, n. 29 (27 luglio 2011): 11299–307. http://dx.doi.org/10.1021/ja203080p.

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