Articoli di riviste sul tema "Small inhibitory compounds"
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Alvarez-Gonzalez, Juan Antonio, Robert Maul, Rahul M. Kohli e Patricia J. Gearhart. "Small molecule inhibitors of Activation-Induced Deaminase". Journal of Immunology 200, n. 1_Supplement (1 maggio 2018): 48.18. http://dx.doi.org/10.4049/jimmunol.200.supp.48.18.
Yan, Hua, Tomoko Chiba Mizutani, Nobuhiko Nomura, Tadakazu Takakura, Yoshihiro Kitamura, Hideka Miura, Masako Nishizawa, Masashi Tatsumi, Naoki Yamamoto e Wataru Sugiura. "A Novel Small Molecular Weight Compound with a Carbazole Structure That Demonstrates Potent Human Immunodeficiency Virus Type-1 Integrase Inhibitory Activity". Antiviral Chemistry and Chemotherapy 16, n. 6 (dicembre 2005): 363–73. http://dx.doi.org/10.1177/095632020501600603.
Asai, Takashi, Tsutomu Takeuchi, Jeff Diffenderfer e L. David Sibley. "Identification of Small-Molecule Inhibitors of Nucleoside Triphosphate Hydrolase in Toxoplasma gondii". Antimicrobial Agents and Chemotherapy 46, n. 8 (agosto 2002): 2393–99. http://dx.doi.org/10.1128/aac.46.8.2393-2399.2002.
Patkar, Chinmay G., Martha Larsen, Michael Owston, Janet L. Smith e Richard J. Kuhn. "Identification of Inhibitors of Yellow Fever Virus Replication Using a Replicon-Based High-Throughput Assay". Antimicrobial Agents and Chemotherapy 53, n. 10 (3 agosto 2009): 4103–14. http://dx.doi.org/10.1128/aac.00074-09.
Han, Chun, Jiahong Ren, Feng Su, Xiaoqin Hu, Mengyao Li, Zhijun Wang e Lintao Wu. "Hybrids of Quinoline and Anilinopyrimidine: Novel EGFRT790M Inhibitors with Antiproliferative Activity against Non-Small Cell Lung Cancer Cell Lines". Anti-Cancer Agents in Medicinal Chemistry 20, n. 6 (14 giugno 2020): 724–33. http://dx.doi.org/10.2174/1871520620666200302113206.
Abramić, Marija, e Dejan Agić. "Survey of Dipeptidyl Peptidase III Inhibitors: From Small Molecules of Microbial or Synthetic Origin to Aprotinin". Molecules 27, n. 9 (7 maggio 2022): 3006. http://dx.doi.org/10.3390/molecules27093006.
Noueiry, Amine O., Paul D. Olivo, Urszula Slomczynska, Yi Zhou, Ben Buscher, Brian Geiss, Michael Engle et al. "Identification of Novel Small-Molecule Inhibitors of West Nile Virus Infection". Journal of Virology 81, n. 21 (22 agosto 2007): 11992–2004. http://dx.doi.org/10.1128/jvi.01358-07.
Lefas, Georgia, e George Chaconas. "High-Throughput Screening Identifies Three Inhibitor Classes of the Telomere Resolvase from the Lyme Disease Spirochete". Antimicrobial Agents and Chemotherapy 53, n. 10 (13 luglio 2009): 4441–49. http://dx.doi.org/10.1128/aac.00529-09.
Ercan-Fang, Nacide, Miriam R. Taylor, Judith L. Treadway, Carolyn B. Levy, Paul E. Genereux, E. Michael Gibbs, Virginia L. Rath, Younggil Kwon, Mary C. Gannon e Frank Q. Nuttall. "Endogenous effectors of human liver glycogen phosphorylase modulate effects of indole-site inhibitors". American Journal of Physiology-Endocrinology and Metabolism 289, n. 3 (settembre 2005): E366—E372. http://dx.doi.org/10.1152/ajpendo.00264.2004.
Yoo, Jihye, Darong Kim, Jiyoung Park, Young-Kook Kim, Hea-Young Park Choo e Hyun Ae Woo. "Novel Small Molecule Inhibitors Targeting the IL-6/STAT3 Pathway or IL-1β". Molecules 27, n. 9 (22 aprile 2022): 2696. http://dx.doi.org/10.3390/molecules27092696.
Ramesh, Priyanka, e Shanthi Veerappapillai. "Designing Novel Compounds for the Treatment and Management of RET-Positive Non-Small Cell Lung Cancer—Fragment Based Drug Design Strategy". Molecules 27, n. 5 (28 febbraio 2022): 1590. http://dx.doi.org/10.3390/molecules27051590.
Gong, Mengdie, Mingyan Tu, Hongxia Sun, Lu Li, Lili Zhu, Honglin Li, Zhenjiang Zhao e Shiliang Li. "Design, Synthesis, and Structure–Activity Relationship Study of Potent MAPK11 Inhibitors". Molecules 27, n. 1 (29 dicembre 2021): 203. http://dx.doi.org/10.3390/molecules27010203.
Tian, Tao, Guo-Ying Chen, Hao Zhang e Feng-Qing Yang. "Personal Glucose Meter for α-Glucosidase Inhibitor Screening Based on the Hydrolysis of Maltose". Molecules 26, n. 15 (30 luglio 2021): 4638. http://dx.doi.org/10.3390/molecules26154638.
Flaumenhaft, Robert, Lynn VerPlank, James R. Dilks, Price S. Blair, Albert Mairuhu, Joseph Negri, Jason Burbank et al. "A Chemical Genetic Analysis of Platelet Activation." Blood 114, n. 22 (20 novembre 2009): 4009. http://dx.doi.org/10.1182/blood.v114.22.4009.4009.
Choi, Ryan, Mowei Zhou, Roger Shek, Jesse W. Wilson, Logan Tillery, Justin K. Craig, Indraneel A. Salukhe et al. "High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity". PLOS ONE 16, n. 4 (22 aprile 2021): e0250019. http://dx.doi.org/10.1371/journal.pone.0250019.
Ruseva, Nina, Hristina Sbirkova-Dimitrova, Mariyana Atanasova, Ana Marković, Žaklina Šmelcerović, Andrija Šmelcerović, Adriana Bakalova e Emiliya Cherneva. "Synthesis and DNase I Inhibitory Properties of New Squaramides". Molecules 28, n. 2 (5 gennaio 2023): 538. http://dx.doi.org/10.3390/molecules28020538.
Huang, Yuting, Zhaoxing Li, Yuan Ma, Qianqian Wu, Jianping Kong, Lijuan Zhao, Shunxiang Li e Juan Li. "Screening for Active Compounds of Acorus calamus against SARS-CoV-2 Viral Protease and Mechanism Prediction". Pharmaceuticals 17, n. 3 (1 marzo 2024): 325. http://dx.doi.org/10.3390/ph17030325.
Sato, Yoshiaki, Ikuo Kashiwakura, Masaru Yamaguchi, Hironori Yoshino, Takeshi Tanaka, Ken Ikeda, Zhengmao Ye, Hirotsugu Komatsu, Takao Matsuzaki e Masato Hosoda. "Discovery of a Novel Small-molecule Interleukin-6 Inhibitor Through Virtual Screening Using Artificial Intelligence". Medicinal Chemistry 18, n. 6 (luglio 2022): 694–700. http://dx.doi.org/10.2174/1573406418666211116144243.
Paiboonrungruang, chorlada. "Abstract 6237: Small molecule screen identifies pyrimethamine as an inhibitor of NRF2-driven esophageal hyperplasia". Cancer Research 83, n. 7_Supplement (4 aprile 2023): 6237. http://dx.doi.org/10.1158/1538-7445.am2023-6237.
Jiang, Suping, Sean T. Prigge, Lan Wei, Yu-e. Gao, Thomas H. Hudson, Lucia Gerena, John B. Dame e Dennis E. Kyle. "New Class of Small Nonpeptidyl Compounds BlocksPlasmodium falciparum Development In Vitro by Inhibiting Plasmepsins". Antimicrobial Agents and Chemotherapy 45, n. 9 (1 settembre 2001): 2577–84. http://dx.doi.org/10.1128/aac.45.9.2577-2584.2001.
Moi, Davide, Alessandro Deplano, Andrea Angeli, Gianfranco Balboni, Claudiu T. Supuran e Valentina Onnis. "Synthesis of Sulfonamides Incorporating Piperidinyl-Hydrazidoureido and Piperidinyl-Hydrazidothioureido Moieties and Their Carbonic Anhydrase I, II, IX and XII Inhibitory Activity". Molecules 27, n. 17 (23 agosto 2022): 5370. http://dx.doi.org/10.3390/molecules27175370.
Al-Sanea, Mohammad M. "Synthesis and biological evaluation of small molecule modulators of CDK8/Cyclin C complex with phenylaminoquinoline scaffold". PeerJ 8 (13 marzo 2020): e8649. http://dx.doi.org/10.7717/peerj.8649.
Gao, Yinghong, Stephen P. Davies, Martin Augustin, Anna Woodward, Umesh A. Patel, Robert Kovelman e Kevin J. Harvey. "A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery". Biochemical Journal 451, n. 2 (28 marzo 2013): 313–28. http://dx.doi.org/10.1042/bj20121418.
Cruz-Migoni, Abimael, Peter Canning, Camilo E. Quevedo, Carole J. R. Bataille, Nicolas Bery, Ami Miller, Angela J. Russell, Simon E. V. Phillips, Stephen B. Carr e Terence H. Rabbitts. "Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds". Proceedings of the National Academy of Sciences 116, n. 7 (25 gennaio 2019): 2545–50. http://dx.doi.org/10.1073/pnas.1811360116.
Ramshini, Hassan, Reza Tayebee, Alessandra Bigi, Francesco Bemporad, Cristina Cecchi e Fabrizio Chiti. "Identification of Novel 1,3,5-Triphenylbenzene Derivative Compounds as Inhibitors of Hen Lysozyme Amyloid Fibril Formation". International Journal of Molecular Sciences 20, n. 22 (7 novembre 2019): 5558. http://dx.doi.org/10.3390/ijms20225558.
Minhas, Richa, e Yogita Bansal. "iNOS inhibitors: Benzimidazole-coumarin derivatives to combat inflammation". European Journal of Chemistry 13, n. 3 (30 settembre 2022): 307–18. http://dx.doi.org/10.5155/eurjchem.13.3.307-318.2282.
Chattopadhyay, Shrikanta, Alison L. Stewart, Siddhartha Mukherjee, Cherrie Huang, Kimberly A. Hartwell, Peter G. Miller, Leigh Carmody et al. "Niche-Based Screening Identifies Novel Small Molecules That Overcome Stromal Effects in Multiple Myeloma". Blood 120, n. 21 (16 novembre 2012): 571. http://dx.doi.org/10.1182/blood.v120.21.571.571.
Adachi, Ryutaro, Tsuyoshi Ishii, Shinichi Matsumoto, Takuya Satou, Junichi Sakamoto e Tomohiro Kawamoto. "Discovery of Human Intestinal MGAT Inhibitors Using High-Throughput Mass Spectrometry". SLAS DISCOVERY: Advancing the Science of Drug Discovery 22, n. 4 (8 ottobre 2016): 360–65. http://dx.doi.org/10.1177/1087057116673181.
Mavridis, Evangelos, Eleftherios Bermperoglou, Eleni Pontiki e Dimitra Hadjipavlou-Litina. "5-(4H)-Oxazolones and Their Benzamides as Potential Bioactive Small Molecules". Molecules 25, n. 14 (11 luglio 2020): 3173. http://dx.doi.org/10.3390/molecules25143173.
Trenholme, Katharine, Linda Marek, Sandra Duffy, Gabriele Pradel, Gillian Fisher, Finn K. Hansen, Tina S. Skinner-Adams et al. "Lysine Acetylation in Sexual Stage Malaria Parasites Is a Target for Antimalarial Small Molecules". Antimicrobial Agents and Chemotherapy 58, n. 7 (14 aprile 2014): 3666–78. http://dx.doi.org/10.1128/aac.02721-13.
Zhao, Hongchuan, Pu Sun, Wei Guo, Yi Wang, Ao Zhang, Linghua Meng e Chunyong Ding. "Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO-1) Inhibitors Based on Ortho-Naphthaquinone-Containing Natural Product". Molecules 24, n. 6 (18 marzo 2019): 1059. http://dx.doi.org/10.3390/molecules24061059.
Furbish, Amelia B., Ahmed S. Alford, Pieter Burger, Yuri K. Peterson, Tracy Murray-Stewart, Robert A. Casero e Patrick M. Woster. "Identification and Characterization of Novel Small-Molecule SMOX Inhibitors". Medical Sciences 10, n. 3 (30 agosto 2022): 47. http://dx.doi.org/10.3390/medsci10030047.
VENÄLÄINEN, Jarkko I., Risto O. JUVONEN, J. Arturo GARCIA-HORSMAN, Erik A. A. WALLÉN, Johannes A. M. CHRISTIAANS, Elina M. JARHO, Jukka GYNTHER e Pekka T. MÄNNISTÖ. "Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site". Biochemical Journal 382, n. 3 (7 settembre 2004): 1003–8. http://dx.doi.org/10.1042/bj20040992.
Kollár, Levente, Martina Gobec, Matic Proj, Lara Smrdel, Damijan Knez, Tímea Imre, Ágnes Gömöry et al. "Fragment-Sized and Bidentate (Immuno)Proteasome Inhibitors Derived from Cysteine and Threonine Targeting Warheads". Cells 10, n. 12 (6 dicembre 2021): 3431. http://dx.doi.org/10.3390/cells10123431.
Nordio, Giulia, Francesco Piazzola, Giorgio Cozza, Monica Rossetto, Manuela Cervelli, Anna Minarini, Filippo Basagni et al. "From Monoamine Oxidase Inhibition to Antiproliferative Activity: New Biological Perspectives for Polyamine Analogs". Molecules 28, n. 17 (29 agosto 2023): 6329. http://dx.doi.org/10.3390/molecules28176329.
Moon, Sungho, Seon Yeon Cho, Minhye Kim, Soojeong Beak, Jinhyuk Kim, Yongchan Kim, Sungil Park et al. "Abstract B142: Discovery of novel and potent TEAD inhibitors, orally available small molecules with anti-tumor activity in hippo pathway- dysregulated cancers". Molecular Cancer Therapeutics 22, n. 12_Supplement (1 dicembre 2023): B142. http://dx.doi.org/10.1158/1535-7163.targ-23-b142.
Rusina, Polina, Erik Gandalipov, Yana Abdusheva, Maria Panova, Alexandra Burdenkova, Vasiliy Chaliy, Maria Brachs et al. "Imidazole-4-N-acetamide Derivatives as a Novel Scaffold for Selective Targeting of Cyclin Dependent Kinases". Cancers 15, n. 15 (25 luglio 2023): 3766. http://dx.doi.org/10.3390/cancers15153766.
Francini, Cinzia, Francesca Musumeci, Anna Fallacara, Lorenzo Botta, Alessio Molinari, Roberto Artusi, Laura Mennuni, Adriano Angelucci e Silvia Schenone. "Optimization of Aminoimidazole Derivatives as Src Family Kinase Inhibitors". Molecules 23, n. 9 (17 settembre 2018): 2369. http://dx.doi.org/10.3390/molecules23092369.
Kulkarni, Amol A., Ayyiliath M. Sajith, Changwen Zhang, Jiukuan Hao e J. Phillip Bowen. "Small molecule prevents inflammation in microglia by targeting the NLRP3 inflammasome". Journal of Immunology 204, n. 1_Supplement (1 maggio 2020): 160.15. http://dx.doi.org/10.4049/jimmunol.204.supp.160.15.
Rampogu, Shailima, Ayoung Baek, Chanin Park, Shraddha Parate, Saravanan Parameswaran, Yohan Park, Baji Shaik, Ju Hyun Kim, Seok Ju Park e Keun Woo Lee. "Discovery of Small Molecules that Target Vascular Endothelial Growth Factor Receptor-2 Signalling Pathway Employing Molecular Modelling Studies". Cells 8, n. 3 (21 marzo 2019): 269. http://dx.doi.org/10.3390/cells8030269.
Gising, Johan, Saman Honarnejad, Maaike Bras, Gemma L. Baillie, Stuart P. McElroy, Philip S. Jones, Angus Morrison, Julia Beveridge, Mathias Hallberg e Mats Larhed. "The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds". International Journal of Molecular Sciences 25, n. 7 (6 aprile 2024): 4084. http://dx.doi.org/10.3390/ijms25074084.
Curreli, Francesca, Shahad Ahmed, Sofia M. B. Victor, Aleksandra Drelich, Siva S. Panda, Andrea Altieri, Alexander V. Kurkin, Chien-Te K. Tseng, Christopher D. Hillyer e Asim K. Debnath. "Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based Assays". Viruses 14, n. 1 (31 dicembre 2021): 69. http://dx.doi.org/10.3390/v14010069.
Elsawi, Ahmed E., Mai I. Shahin, Hager A. Elbendary, Tarfah Al-Warhi, Fatma E. Hassan e Wagdy M. Eldehna. "1,2,4-Triazole-Tethered Indolinones as New Cancer-Fighting Small Molecules Targeting VEGFR-2: Synthesis, Biological Evaluations and Molecular Docking". Pharmaceuticals 17, n. 1 (8 gennaio 2024): 81. http://dx.doi.org/10.3390/ph17010081.
Porubin, Diana. "Inhibition of in Vitro Nitrosation of Nornicotine". Chemistry Journal of Moldova 2, n. 1 (dicembre 2007): 78–82. http://dx.doi.org/10.19261/cjm.2007.02(1).11.
Montanari, Floriane, Anna Cseke, Katrin Wlcek e Gerhard F. Ecker. "Virtual Screening of DrugBank Reveals Two Drugs as New BCRP Inhibitors". SLAS DISCOVERY: Advancing the Science of Drug Discovery 22, n. 1 (11 luglio 2016): 86–93. http://dx.doi.org/10.1177/1087057116657513.
Zhang, Hao, Feng-Qing Yang e Jian-Li Gao. "A Simple and Portable Personal Glucose Meter Method Combined with Molecular Docking for Screening of Lipase Inhibitors". Evidence-Based Complementary and Alternative Medicine 2022 (22 settembre 2022): 1–9. http://dx.doi.org/10.1155/2022/4430050.
Alkhashrom, Sewar, Jintawee Kicuntod, Sigrun Häge, Johannes Schweininger, Yves A. Muller, Peter Lischka, Manfred Marschall e Jutta Eichler. "Exploring the Human Cytomegalovirus Core Nuclear Egress Complex as a Novel Antiviral Target: A New Type of Small Molecule Inhibitors". Viruses 13, n. 3 (12 marzo 2021): 471. http://dx.doi.org/10.3390/v13030471.
Yang, Cheng-Wei, Yung-Ning Yang, Po-Huang Liang, Chi-Min Chen, Wei-Liang Chen, Hwan-You Chang, Yu-Sheng Chao e Shiow-Ju Lee. "Novel Small-Molecule Inhibitors of Transmissible Gastroenteritis Virus". Antimicrobial Agents and Chemotherapy 51, n. 11 (20 agosto 2007): 3924–31. http://dx.doi.org/10.1128/aac.00408-07.
Liargkova, Thalia, Nikolaos Eleftheriadis, Frank Dekker, Efstathia Voulgari, Constantinos Avgoustakis, Marina Sagnou, Barbara Mavroidi, Maria Pelecanou e Dimitra Hadjipavlou-Litina. "Small Multitarget Molecules Incorporating the Enone Moiety". Molecules 24, n. 1 (7 gennaio 2019): 199. http://dx.doi.org/10.3390/molecules24010199.
Zhang, Yan, e Niefang Yu. "Design, Synthesis and Biological Evaluation: 5-amino-1H-pyrazole-1- carbonyl derivatives as FGFR Inhibitors". Letters in Drug Design & Discovery 17, n. 11 (23 ottobre 2020): 1330–41. http://dx.doi.org/10.2174/1570180817999200608140628.