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Letteratura scientifica selezionata sul tema "SMALED"

Autore: Grafiati

Pubblicato: 7 dicembre 2024

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Articoli di riviste sul tema "SMALED"

Sharkova, I. V., P. A. Shatalov e E. L. Dadali. "VARIETY OF CLINICAL MANIFESTATIONS IN MUTATIONS IN THE DYNC1H1 GENE". Russian neurological Journal, n. 3 (3 settembre 2019): 31–36. http://dx.doi.org/10.30629/2658-7947-2019-24-3-31-36.

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Introduction. To date, DYNC1H1 gene mutations are known for large number of hereditary diseases. It is believed that different mutations have variable effects to protein function and, accordingly, to various clinical manifestations. Results. There are a clinical and genetic characteristics of two Russian patients with two types of diseases: spinal muscular atrophy with predominant lesion of the lower extremities (SMALED) and non-syndromic mental retardation type 13 (MR13) in combination with a brain malformations and epilepsy due to newly identified mutations in the DYNC1H1 gene. Conclusion There is some evidence in support of the hypothesis that the amino acid sequence changing in the tail domain of dynein lead to the appearance of SMALED, and in the motor domain lead to MR13. Exome or genome sequencing are required as the main method for their diagnosis due to the high genetic heterogeneity of non-syndromic MR and SMALED, the lack of specific clinical markers and hotspot mutations in the DYNC1H1 gene.

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Ribeiro-Mourão, Francisco, Ana Vilan, Sara Passos-Silva, Fernando Silveira, Miguel Leão e Mafalda Sampaio. "Intrafamilial Variability of the R694C Variant in BICD2 Presenting with Lethal Severe Arthrogryposis". Journal of Neonatology 36, n. 1 (11 gennaio 2022): 63–68. http://dx.doi.org/10.1177/09732179211068815.

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Arthrogryposis multiplex congenita (AMC) is a heterogeneous condition comprising congenital multiple joint contractures, and it is secondary to decreased fetal mobility following environmental/genetic abnormalities. BICD2 pathogenic variants have been associated with autosomal dominant spinal muscular atrophy with lower extremity predominance (SMALED2). We report the case of a newborn with decreased fetal movements and ventriculomegaly diagnosed in utero, born with severe AMC, multiple bone fractures, congenital hip dislocation, and respiratory insufficiency that led to neonatal death. His mother had AMC diagnosis without established etiology. Her phenotype characterization was key to guide the genetic investigation. A BICD 2 heterozygous variant (NM_001003800.1; c.2080C > T; p. [Arg694Cys]) was detected both in the mother and the newborn. This variant had previously been reported in 3 cases, all having de novo severe SMALED-type 2B (MIM#618291) phenotype. This is the first report of this variant (p. [Arg694Cys]) presenting with an inherited, severe, and lethal phenotype associated to intrafamilial variability, suggesting a more complex phenotype-genotype correlation than previously stated.

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Aziz, Iqra, Mark Davis e Christina Liang. "Late adult-onset spinal muscular atrophy with lower extremity predominance (SMALED)". BMJ Case Reports 15, n. 3 (marzo 2022): e248297. http://dx.doi.org/10.1136/bcr-2021-248297.

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An elderly man in his early 80s presented with a 6-month history of worsening lower limb weakness on a background of a longer-standing waddling gait. Examination revealed bilateral scapular winging, and weakness in his proximal and distal lower limbs. Electromyography showed widespread chronic partial denervation changes, while sensory and motor nerve conduction parameters were preserved. After little progression over the course of 18 months, motor neuron disease was deemed less likely. Genetic testing revealed BICD2-related spinal muscular atrophy with lower extremity dominance (SMALED2), a disease that is usually of earlier onset. He is the oldest patient in the literature to be diagnosed with SMALED2 while maintaining ambulation, suggesting the milder spectrum of BICD2-related disease.

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Trimouille, Aurélien, Émilie Obre, Guillaume Banneau, Alexandra Durr, Giovanni Stevanin, Fabienne Clot, Perrine Pennamen et al. "An in-frame deletion in BICD2 associated with a non-progressive form of SMALED". Clinical Neurology and Neurosurgery 166 (marzo 2018): 1–3. http://dx.doi.org/10.1016/j.clineuro.2018.01.013.

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Hemerková, Pavlína, Hana Matulová, Pavel Kunc, Lenka Pospíšlová e Jiří Jandura. "Spinal muscular atrophy affecting the lower limbs, dominantly inherited (SMALED), an example of a non-5q form of the disease". Neurologie pro praxi 24, n. 1 (3 marzo 2023): 65–69. http://dx.doi.org/10.36290/neu.2022.051.

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WIELER, SUSANA. "Smale spaces via inverse limits". Ergodic Theory and Dynamical Systems 34, n. 6 (28 giugno 2013): 2066–92. http://dx.doi.org/10.1017/etds.2013.19.

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AbstractA Smale space is a chaotic dynamical system with canonical coordinates of contracting and expanding directions. The basic sets for Smale’s Axiom $A$ systems are a key class of examples. We consider the special case of irreducible Smale spaces with zero-dimensional contracting directions, and characterize these as stationary inverse limits satisfying certain conditions.

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Barinova, M. K., E. Y. Gogulina e O. V. Pochinka. "Omega-classification of Surface Diffeomorphisms Realizing Smale Diagrams". Nelineinaya Dinamika 17, n. 3 (2021): 321–34. http://dx.doi.org/10.20537/nd210306.

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The present paper gives a partial answer to Smale’s question which diagrams can correspond to $(A,B)$-diffeomorphisms. Model diffeomorphisms of the two-dimensional torus derived by “Smale surgery” are considered, and necessary and sufficient conditions for their topological conjugacy are found. Also, a class $G$ of $(A,B)$-diffeomorphisms on surfaces which are the connected sum of the model diffeomorphisms is introduced. Diffeomorphisms of the class $G$ realize any connected Hasse diagrams (abstract Smale graph). Examples of diffeomorphisms from $G$ with isomorphic labeled Smale diagrams which are not ambiently $\Omega$-conjugated are constructed. Moreover, a subset $G_{*}\subset G$ of diffeomorphisms for which the isomorphism class of labeled Smale diagrams is a complete invariant of the ambient $\Omega$-conjugacy is singled out.

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Becker, Lena-Luise, Hormos Salimi Dafsari, Jens Schallner, Dalia Abdin, Michael Seifert, Florence Petit, Thomas Smol et al. "The clinical-phenotype continuum in DYNC1H1-related disorders—genomic profiling and proposal for a novel classification". Journal of Human Genetics 65, n. 11 (12 agosto 2020): 1003–17. http://dx.doi.org/10.1038/s10038-020-0803-1.

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AbstractMutations in the cytoplasmic dynein 1 heavy chain gene (DYNC1H1) have been identified in rare neuromuscular (NMD) and neurodevelopmental (NDD) disorders such as spinal muscular atrophy with lower extremity dominance (SMALED) and autosomal dominant mental retardation syndrome 13 (MRD13). Phenotypes and genotypes of ten pediatric patients with pathogenic DYNC1H1 variants were analyzed in a multi-center study. Data mining of large-scale genomic variant databases was used to investigate domain-specific vulnerability and conservation of DYNC1H1. We identified ten patients with nine novel mutations in the DYNC1H1 gene. These patients exhibit a broad spectrum of clinical findings, suggesting an overlapping disease manifestation with intermixed phenotypes ranging from neuropathy (peripheral nervous system, PNS) to severe intellectual disability (central nervous system, CNS). Genomic profiling of healthy and patient variant datasets underlines the domain-specific effects of genetic variation in DYNC1H1, specifically on toleration towards missense variants in the linker domain. A retrospective analysis of all published mutations revealed domain-specific genotype–phenotype correlations, i.e., mutations in the dimerization domain with reductions in lower limb strength in DYNC1H1–NMD and motor domain with cerebral malformations in DYNC1H1–NDD. We highlight that the current classification into distinct disease entities does not sufficiently reflect the clinical disease manifestation that clinicians face in the diagnostic work-up of DYNC1H1-related disorders. We propose a novel clinical classification for DYNC1H1-related disorders encompassing a spectrum from DYNC1H1–NMD with an exclusive PNS phenotype to DYNC1H1–NDD with concomitant CNS involvement.

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Hoang, Ha Thi, Max A. Schlager, Andrew P. Carter e Simon L. Bullock. "DYNC1H1 mutations associated with neurological diseases compromise processivity of dynein–dynactin–cargo adaptor complexes". Proceedings of the National Academy of Sciences 114, n. 9 (14 febbraio 2017): E1597—E1606. http://dx.doi.org/10.1073/pnas.1620141114.

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Mutations in the human DYNC1H1 gene are associated with neurological diseases. DYNC1H1 encodes the heavy chain of cytoplasmic dynein-1, a 1.4-MDa motor complex that traffics organelles, vesicles, and macromolecules toward microtubule minus ends. The effects of the DYNC1H1 mutations on dynein motility, and consequently their links to neuropathology, are not understood. Here, we address this issue using a recombinant expression system for human dynein coupled to single-molecule resolution in vitro motility assays. We functionally characterize 14 DYNC1H1 mutations identified in humans diagnosed with malformations in cortical development (MCD) or spinal muscular atrophy with lower extremity predominance (SMALED), as well as three mutations that cause motor and sensory defects in mice. Two of the human mutations, R1962C and H3822P, strongly interfere with dynein’s core mechanochemical properties. The remaining mutations selectively compromise the processive mode of dynein movement that is activated by binding to the accessory complex dynactin and the cargo adaptor Bicaudal-D2 (BICD2). Mutations with the strongest effects on dynein motility in vitro are associated with MCD. The vast majority of mutations do not affect binding of dynein to dynactin and BICD2 and are therefore expected to result in linkage of cargos to dynein–dynactin complexes that have defective long-range motility. This observation offers an explanation for the dominant effects of DYNC1H1 mutations in vivo. Collectively, our results suggest that compromised processivity of cargo–motor assemblies contributes to human neurological disease and provide insight into the influence of different regions of the heavy chain on dynein motility.

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Amini, Massoud, Ian F. Putnam e Sarah Saeidi Gholikandi. "Homology for one-dimensional solenoids". MATHEMATICA SCANDINAVICA 121, n. 2 (22 ottobre 2017): 219. http://dx.doi.org/10.7146/math.scand.a-26265.

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Smale spaces are a particular class of hyperbolic topological dynamical systems, defined by David Ruelle. The definition was introduced to give an axiomatic description of the dynamical properties of Smale's Axiom A systems when restricted to a basic set. They include Anosov diffeomeorphisms, shifts of finite type and various solenoids constructed by R. F. Williams. The second author constructed a homology theory for Smale spaces which is based on (and extends) Krieger's dimension group invariant for shifts of finite type. In this paper, we compute this homology for the one-dimensional generalized solenoids of R. F. Williams.

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Tesi sul tema "SMALED"

Calon, Maëliss. "Étude des bases moléculaires et cellulaires de la vulnérabilité des neurones moteurs dans l'amyotrophie spinale distale des membres inférieurs". Electronic Thesis or Diss., Sorbonne université, 2024. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2024SORUS282.pdf.

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Les altérations du transport intracellulaire peuvent provoquer une neurodégénérescence ou entraver le développement des circuits neuronaux. Ainsi, des mutations dominantes dans DYNC1H1 (chaîne lourde de la dynéine) et dans son partenaire BICD2, deux composants essentiels de la machinerie de transport intracellulaire, sont à l'origine d'une maladie neurodéveloppementale des motoneurones appelée amyotrophie spinale avec prédominance des membres inférieurs (SMALED). Dans cette maladie, les motoneurones innervant les membres sont sélectivement affectés indiquant une dépendance graduelle au transport intracellulaire parmi les types neuronaux et même les sous-types spécifiques de motoneurones. Mon travail de thèse a visé à étudier les mécanismes responsables de l'atteinte des motoneurones dans cette maladie. En analysant les premiers modèles murins porteur d'une mutation causale de SMALED dans BICD2, j'ai observé que ce type de mutation peut induire une perte de la protéine BICD2 contrairement à ce qui est observé chez les patients. Cette mutation entraîne la mort in utero des embryons homozygotes mais les animaux hétérozygotes, correspondants à la configuration génétique chez l'homme, ne présente pas de phénotypes. Ces résultats suggèrent que les modèles murins de SMALED pourraient, au moins dans certains cas, mimer imparfaitement la maladie. J'ai alors développé un modèle complémentaire humain basé sur la différenciation en motoneurones de cellules souches pluripotentes induites humaines (CSPih) dérivées de patients SMALED. J'ai montré que les mutations SMALED n'ont pas d'impact sur la spécification et la survie des motoneurones. En revanche, le transport axonal de vésicules impliquées dans la signalisation par les facteurs neurotrophiques (FNTs), semble affecté, ainsi que la réponse au GDNF, un FNT essentiel à l'innervation musculaire et à la survie de certains groupes de motoneurones. Mes résultats suggèrent que SMALED pourrait être dû à des défauts de transport axonal qui perturberaient l'intégration de la signalisation par les FNTs qui sont essentiels au développement et au maintien des circuits locomoteurs, en particulier ceux contrôlant les membres. Le développement de nouvelles conditions de maturation des motoneurones humains lors de ma thèse permettra de mieux comprendre les liens entre signalisation rétrograde par les FNTs, le développement des circuits moteurs et la dérégulation de ces voies dans les maladies au-delà de SMALED
Intracellular transport alterations can cause neurodegeneration or hinder the development of neural circuits. Dominant mutations in DYNC1H1 (dynein heavy chain) and its partner BICD2, two essential components of intracellular transport machinery, underlie a neurodevelopmental motor neuron disease called spinal muscular atrophy with lower extremity predominance (SMALED). In this disease, motor neurons innervating the limbs are selectively affected, indicating a gradual dependence on intracellular transport among neuronal types and even motor neuron subtypes. My thesis work aimed to study the mechanisms responsible for motor neuron impairment in this disease. By analyzing the first mouse models carrying a SMALED-inducing point mutation in BICD2, I observed that this type of mutation can induce a loss of the BICD2 protein, unlike what is observed in patients. This mutation results in the in-utero death of homozygous embryos, but heterozygous animals, which correspond to the genetic configuration in patients, do not present a phenotype. These results suggest that mouse models of SMALED may, at least in some cases, imperfectly mimic the disease. I therefore developed a complementary human model based on the differentiation into motor neurons of human induced pluripotent stem cells (hiPSCs) derived from SMALED patients. I showed that SMALED mutations do not impact the specification and survival of motor neurons. However, the axonal transport of vesicles involved in neurotrophic factor (NTF) signaling seems affected, as well as the response to GDNF, an NTF essential for muscle innervation and the survival of certain motor neuron groups. My results suggest that SMALED could be due to defects in axonal transport that disrupt the integration of NTF signaling, which is essential for the development and maintenance of locomotor circuits, particularly those controlling the limbs. The development of new conditions for the maturation of human motor neurons during my thesis will provide a better understanding of the links between retrograde signaling by NTF, the development of motor circuits and the deregulation of these pathways in diseases beyond SMALED

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Šenk, Miroslav. "Využití spektrální analýzy pro převod trojúhelníkových polygonálních 3D sítí na 3D spline plochy". Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2007. http://www.nusl.cz/ntk/nusl-412770.

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In this work we deal with conversion of 3D triagonal polygonal meshes to the 3D spline patches using spectral analysis. The converted mesh is divided into quadrilaterals using eigenvectors of Laplacian operator. These quadrilaterals will be converted into spline patches. We will present some interesting results of this method. The assets and imperfections of this method will be briefly discussed.

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Potts, Joanne M. "Estimating abundance of rare, small mammals : a case study of the Key Largo woodrat (Neotoma floridana smalli)". Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/2068.

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Estimates of animal abundance or density are fundamental quantities in ecology and conservation, but for many species such as rare, small mammals, obtaining robust estimates is problematic. In this thesis, I combine elements of two standard abundance estimation methods, capture-recapture and distance sampling, to develop a method called trapping point transects (TPT). In TPT, a "detection function", g(r) (i.e. the probability of capturing an animal, given it is r m from a trap when the trap is set) is estimated using a subset of animals whose locations are known prior to traps being set. Generalised linear models are used to estimate the detection function, and the model can be extended to include random effects to allow for heterogeneity in capture probabilities. Standard point transect methods are modified to estimate abundance. Two abundance estimators are available. The first estimator is based on the reciprocal of the expected probability of detecting an animal, ^P, where the expectation is over r; whereas the second estimator is the expectation of the reciprocal of ^P. Performance of the TPT method under various sampling efforts and underlying true detection probabilities of individuals in the population was investigated in a simulation study. When underlying probability of detection was high (g(0) = 0:88) and between-individual variation was small, survey effort could be surprisingly low (c. 510 trap nights) to yield low bias (c. 4%) in the two estimators; but under certain situations, the second estimator can be extremely biased. Uncertainty and relative bias in population estimates increased with decreasing detectability and increasing between-individual variation. Abundance of the Key Largo woodrat (Neotoma floridana smalli), an endangered rodent with a restricted geographic range, was estimated using TPT. The TPT method compared well to other viable methods (capture-recapture and spatially-explicit capture-recapture), in terms of both field practicality and cost. The TPT method may generally be useful in estimating animal abundance in trapping studies and variants of the TPT method are presented.

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Högele, Michael, e Ilya Pavlyukevich. "Metastability of Morse-Smale dynamical systems perturbed by heavy-tailed Lévy type noise". Universität Potsdam, 2014. http://opus.kobv.de/ubp/volltexte/2014/7063/.

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We consider a general class of finite dimensional deterministic dynamical systems with finitely many local attractors each of which supports a unique ergodic probability measure, which includes in particular the class of Morse–Smale systems in any finite dimension. The dynamical system is perturbed by a multiplicative non-Gaussian heavytailed Lévy type noise of small intensity ε > 0. Specifically we consider perturbations leading to a Itô, Stratonovich and canonical (Marcus) stochastic differential equation. The respective asymptotic first exit time and location problem from each of the domains of attractions in case of inward pointing vector fields in the limit of ε-> 0 has been investigated by the authors. We extend these results to domains with characteristic boundaries and show that the perturbed system exhibits a metastable behavior in the sense that there exits a unique ε-dependent time scale on which the random system converges to a continuous time Markov chain switching between the invariant measures. As examples we consider α-stable perturbations of the Duffing equation and a chemical system exhibiting a birhythmic behavior.

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Tognoloni, Cecilia. "Formation of polymer lipid nanodiscs for membrane protein studies". Thesis, University of Bath, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760950.

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Small, LaCee M. "Effects of data-driven instruction and goal setting on science learning and test scores". Montana State University, 2012. http://etd.lib.montana.edu/etd/2012/small/SmallL0812.pdf.

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Data-driven instruction and goal setting are by no means new to the field of education. This study examined how data-driven instruction combined with student goal setting affected test scores and student engagement as well as how it affected my teaching practices. Analysis of surveys, test scores, journals, interviews and observation protocols indicate that while there was no significant improvement in student engagement in science as observed by teachers and self-reported by students, test scores did increase and students enjoyed the goal setting process and felt that it helped their learning.

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Haynes, Elizabeth Lydia. "Smale Flows on Three Dimensional Manifolds". OpenSIUC, 2012. https://opensiuc.lib.siu.edu/dissertations/470.

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We discuss how to realize simple Smale Flows on 3-manifolds. We focus on three questions: (1) What are the topological conjugate classes of Lorenz Smale flows that can be realized on S3? (2) Which 3-manifolds can also admit a Lorenz Smale flow? (3) What are the topological conjugate classes of simple Smale flows whose saddle set can be modeled by &nu(0+,0+,0,0) can be realized on S3? This dissertation extends the work of M. Sullivan and B. Yu.

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Betermin, Laurent. "Energies de réseaux et calcul variationnel". Thesis, Paris Est, 2015. http://www.theses.fr/2015PEST1006/document.

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Dans cette thèse, nous étudions des problèmes de minimisation d'énergies discrètes et nous cherchons à comprendre pourquoi une structure périodique peut être un minimiseur pour une énergie d'interaction, c'est ce que l'on appelle un problème de cristallisation. Après avoir montré qu'un réseau de R^d soumis à un certain potentiel paramétré peut être vu comme un minimum local, nous démontrons des résultats d'optimalité du réseau triangulaire parmi les réseaux de Bravais du plan pour certaines énergies par point, avec ou sans densité fixée. Finalement, nous démontrons, à partir des travaux de Sandier et Serfaty sur les gaz de Coulomb bidimensionnels, la conjecture de Rakhmanov-Saff-Zhou, c'est-à-dire l'existence d'un terme d'ordre n dans le développement asymptotique de l'énergie logarithmique optimale pour n points sur la sphère unité de R^3. De plus, nous montrons l'équivalence entre la conjecture de Brauchart-Hardin-Saff portant sur la valeur de ce terme d'ordre n et celle de Sandier-Serfaty sur l'optimalité du réseau triangulaire pour une énergie coulombienne renormalisée
In this thesis, we study minimization problems for discrete energies and we search to understand why a periodic structure can be a minimizer for an interaction energy, that is called a crystallization problem. After showing that a given Bravais lattice of R^d submitted to some parametrized potential can be viewed as a local minimum, we prove that the triangular lattice is optimal, among Bravais lattices of R^2, for some energies per point, with or without a fixed density. Finally, we prove, from Sandier and Serfaty works about 2D Coulomb gases, Rakhmanov-Saff-Zhou conjecture, that is to say the existence of a term of order n in the asymptotic expansion of the optimal logarithmic energy for n points on the 2-sphere. Furthermore, we show the equivalence between Brauchart-Hardin-Saff conjecture about the value of this term of order n and Sandier-Serfaty conjecture about the optimality of triangular lattice for a coulombian renormalized energy

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Coelho, José Augusto [UNESP]. "Interpretação eletrostática e a conjectura se Smale". Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/94276.

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Made available in DSpace on 2014-06-11T19:26:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-25Bitstream added on 2014-06-13T19:55:24Z : No. of bitstreams: 1 coelho_ja_me_sjrp.pdf: 348011 bytes, checksum: 34e9942042312b5c3c0bd68f0673e590 (MD5)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Nesta dissertação estudamos a conjectura de Smale junto com a maioria dos resultados sobre este assunto e sua interpretação eletrostática. Mostramos alguns testes numéricos sobre a citada conjectura, para podermos analisar sua interpretação eletrostática.
In this dissertation we study a conjecture of smale together with majority of results about this topic and its electrostatic interpretation. We show some numerical tests concerning the conjecture in order to analise its electrostatic interpretation.

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Coelho, José Augusto. "Interpretação eletrostática e a conjectura se Smale /". São José do Rio Preto : [s.n.], 2010. http://hdl.handle.net/11449/94276.

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Orientador: Dimitar Kolev Dimitrov
Banca: Ana Paula Peron
Banca: Cleonice Fátima Bracciali
Resumo: Nesta dissertação estudamos a conjectura de Smale junto com a maioria dos resultados sobre este assunto e sua interpretação eletrostática. Mostramos alguns testes numéricos sobre a citada conjectura, para podermos analisar sua interpretação eletrostática.
Abstract: In this dissertation we study a conjecture of smale together with majority of results about this topic and its electrostatic interpretation. We show some numerical tests concerning the conjecture in order to analise its electrostatic interpretation.
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Libri sul tema "SMALED"

Hager, Mandy. Smashed. Auckland, N.Z: Random House New Zealand, 2007.

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1937-, Williams Gwynne, e Chess Victoria, a cura di. Smalwod. Aberystwyth: Gwasg Cambria, 1991.

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Shohet, Uri. Smalah. Yehud Monoson: Ofir bikurim, 2022.

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Batacan, F. H. Smaller and smaller circles: A novel. Diliman, Quezon City: University of the Philippines Press, 2002.

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Liepins, Laudis. Smalki Laudis. Riga: Liesma, 1990.

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Boyle, Martin. The smalls. Highfield: B&T, 1998.

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Couture, François. Denis Smalley. Paris: INA/GRM, 2010.

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Bonatti, Christian. Difféomorphismes de smale des surfaces. Paris: Société mathématique de France, 1998.

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Bonatti, C. Difféomorphismes de Smale des surfaces. Paris: Société mathématique de France, 1998.

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Putnam, Ian F. A homology theory for Smale spaces. Providence, Rhode Island: American Mathematical Society, 2014.

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Capitoli di libri sul tema "SMALED"

Guerraggio, Angelo. "Stephen Smale". In Mathematical Lives, 191–96. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-13606-1_27.

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Howie, Crawford. "Small is beautiful: Schubert’s smaller sacred works". In The Unknown Schubert, 59–80. Routledge, 2017. http://dx.doi.org/10.4324/9781315085012-4.

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"Foreword". In Small States. Commonwealth, 1998. http://dx.doi.org/10.14217/smalst-1997-1-en.

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"Major Economic Trends in Commonwealth Small States". In Small States, 1–14. Commonwealth, 1998. http://dx.doi.org/10.14217/smalst-1997-2-en.

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"Commonwealth Small States and the International Trading System". In Small States, 15–32. Commonwealth, 1998. http://dx.doi.org/10.14217/smalst-1997-3-en.

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"Manufacturing Competitiveness with Special Reference to Small States". In Small States, 33–51. Commonwealth, 1998. http://dx.doi.org/10.14217/smalst-1997-4-en.

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"Basic Statistics". In Small States, 52–152. Commonwealth, 1998. http://dx.doi.org/10.14217/smalst-1997-5-en.

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"Foreword". In Small States. Commonwealth, 1998. http://dx.doi.org/10.14217/smalst-1998-1-en.

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"Recent Economic Trends in Commonwealth Small States". In Small States, 1–18. Commonwealth, 1998. http://dx.doi.org/10.14217/smalst-1998-2-en.

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"An Overview of Vulnerability Issues". In Small States, 19–23. Commonwealth, 1998. http://dx.doi.org/10.14217/smalst-1998-3-en.

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Atti di convegni sul tema "SMALED"

Wang, Zhenwei, Haiying Zhang e Tingxian Gao. "Small Target Detection Based on Enhanced RFCN Driven By Smaller Data Set". In ICRCA 2019: 2019 The 4th International Conference on Robotics, Control and Automation. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3351180.3351181.

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Loscombe, R. "The ISO 12215 Scantling Standard – Development and Implementation". In Small Craft Regulations. RINA, 2004. http://dx.doi.org/10.3940/rina.sc.2004.06.

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Hanbidge, Philip J. "A Mission-Driven Approach To Vessel Design". In Small Craft Safety. RINA, 2001. http://dx.doi.org/10.3940/rina.sc.2001.03.

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Hentinen, Markku. "Workboat Design with Self-Organising Map Technique (SOM)". In Small Craft Safety. RINA, 2001. http://dx.doi.org/10.3940/rina.sc.2001.02.

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Francescutto, Alberto, Antonio Cardo e Giulio Russo Krauss. "Dynamic Stability and Effect of Water on Deck Small Fishing Vessels". In Small Craft Safety. RINA, 2001. http://dx.doi.org/10.3940/rina.sc.2001.06.

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Kuo, C., S. Houison Craufurd e M. McGowan. "Application of Formal Safety Management to Small Craft Safety". In Small Craft Safety. RINA, 2001. http://dx.doi.org/10.3940/rina.sc.2001.11.

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Deakin, Barry. "The Stability of Beam Trawlers". In Small Craft Safety. RINA, 2001. http://dx.doi.org/10.3940/rina.sc.2001.05.

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Holm, Gunnar. "Critical Safety Principles in Small Craft Design and Rule Development". In Small Craft Safety. RINA, 2001. http://dx.doi.org/10.3940/rina.sc.2001.12.

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Dahle, Emil Aall, Gisli Viggosson e Dag Myrhaug. "Safe Operation of Fishing Vessels Based Upon Continuous Measurements of Environmental Conditions and Vessel Stability". In Small Craft Safety. RINA, 2001. http://dx.doi.org/10.3940/rina.sc.2001.07.

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Boccadamo, G., R. Pennarola, A. Scamardella e G. Simeon. "Working Conditions on Small Fishing Vessels: Accident Investigation, Seaworthiness and Design Aspects". In Small Craft Safety. RINA, 2001. http://dx.doi.org/10.3940/rina.sc.2001.09.

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Rapporti di organizzazioni sul tema "SMALED"

Hangen, Eric, e Michael E. Hangen. CDFIs Can Make the SBA PPP Loan Program Work for Smaller, Minority-Owned, and Women-Owned, Small Businesses. University of New Hampshire Libraries, 2020. http://dx.doi.org/10.34051/p/2020.386.

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Wiersch, AnnMarie, Scott Lieberman e Barbara J. Lipman. Click, Submit 2.0: An Update on Online Lender Applicants from the Small Business Credit Survey. Federal Reserve Bank of Cleveland, dicembre 2019. http://dx.doi.org/10.26509/frbc-cd-20191218.

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Abstract (sommario):

This study presents an analysis of data from the 2018 Small Business Credit Survey. The findings shed light on the types of small firms using online lenders, their application experiences, and credit outcomes. Among the main findings: Firms that apply at online lenders are more likely to be smaller, have lower credit scores, report more financial challenges, and be less profitable than firms that apply at only traditional lenders. In addition, black-owned and Hispanic-owned firms are more likely than white-owned and Asian-owned firms to report they applied at an online lender. Furthermore, online-lender applicants are more likely than traditional-lender applicants to apply for smaller amounts of financing and to seek funding to cover operating expenses. Finally, online-lender applicants reported greater success obtaining credit than traditional-lender-only applicants, despite having lower credit scores, and they are less satisfied with their lenders.

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Olarreaga, Marcelo, e Andreas Lendle. Can Online Markets Make Trade More Inclusive? Inter-American Development Bank, marzo 2014. http://dx.doi.org/10.18235/0006985.

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Technology made available by online markets has signifcantly reducedthe cost of entry into international markets for small and medium sized firms, who can now reach far away consumers and create global reputation as a seller at very low costs. Empirical evidence using data from eBay sellers shows that a large share of online firms exports, even though they are on average much smaller than traditional offline firms. We show that in a world where income inequality is driven by an uneven distribution of capital rents, online markets help to reduce income inequality by providing smaller firms access to international markets.

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Athey, Susan, Christian Catalini e Catherine Tucker. The Digital Privacy Paradox: Small Money, Small Costs, Small Talk. Cambridge, MA: National Bureau of Economic Research, giugno 2017. http://dx.doi.org/10.3386/w23488.

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Koopmann, Patrick, e Jieying Chen. Deductive Module Extraction for Expressive Description Logics (Extended Version). Technische Universität Dresden, 2020. http://dx.doi.org/10.25368/2022.262.

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In deductive module extraction, we determine a small subset of an ontology for a given vocabulary that preserves all logical entailments that can be expressed in that vocabulary. While in the literature stronger module notions have been discussed, we argue that for applications in ontology analysis and ontology reuse, deductive modules, which are decidable and potentially smaller, are often sufficient. We present methods based on uniform interpolation for extracting different variants of deductive modules, satisfying properties such as completeness, minimality and robustness under replacements, the latter being particularly relevant for ontology reuse. An evaluation of our implementation shows that the modules computed by our method are often significantly smaller than those computed by existing methods.

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Westley, Glenn D. Can Financial Market Policies Reduce Income Inequality? Inter-American Development Bank, ottobre 2001. http://dx.doi.org/10.18235/0008882.

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This paper seeks to answer two questions: How can we further develop a country¿s microfinance industry and what impact might this have on the country¿s income distribution?. Also it presents substantial arguments and data to support the contention that improving the access of micro and small enterprises to financial services could have an important salutary impact on a country's income distribution. To demonstrate this, the paper shows first that many poor own or are employed by smaller enterprises, second that smaller enterprises are indeed poorly served with formal and semi-formal credit, and third that providing financial services to smaller enterprises increases their income and employment and reduces income inequality to an important degree. Using household survey data from 15 Latin American countries, the paper finds that while the microenterprise sector accounts for 56 percent of all earners in the region, it includes 70 percent of the region's poor earners (with 35 percent of the poor earners being single-person-firm owners and the other 35 percent microenterprise employees).

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Thorn, R. J. Conductors with small Fermi energies and small gap energies. Office of Scientific and Technical Information (OSTI), settembre 1993. http://dx.doi.org/10.2172/10184534.

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Douville, Travis, Mark Severy, Lorin Wall e Kendall Mongird. Small Hydropower Interconnections: Small Hydropower in the United States. Office of Scientific and Technical Information (OSTI), agosto 2022. http://dx.doi.org/10.2172/1882596.

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Cooper, Rachel. Water in Sustainable Agriculture Standards. Institute of Development Studies (IDS), gennaio 2021. http://dx.doi.org/10.19088/k4d.2021.037.

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This review synthesises evidence on water in sustainable agriculture standards. Sustainable agricultural standards, hereafter standards, is a broad term encompassing certification schemes, tools, and programmes. The International Trade Centre’s Sustainability Standards Map includes 166 agricultural standards . However, there is a smaller number of prominent standards that are popularly used by major retailers or for particular commodities. Two studies looking at how water is considered in standards selected smaller numbers: Morgan (2017) benchmarks 25 popular use conventional agricultural standards and organic standards, whilst Vos & Boelens (2014) selected eight prominent standards for their analysis. The evidence base for this request was limited. Whilst water is included in individual standards, there is limited research on the efficacy or impact of standards on water issues. This review identified an extremely small number of studies that either assessed or benchmarked standards’ water related requirements or the impacts of certification and water requirements on water resources.

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Lacy, Susan Whitney, e Christopher Robert Saunders. The hardware of smaller clusters. Office of Scientific and Technical Information (OSTI), agosto 2018. http://dx.doi.org/10.2172/1465636.

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