Articoli di riviste: "Skin carcinoma"

1

Rosen, Jordan, Katherine Nolan, Noah Shaikh, Les Rosen e Martin Zaiac. "Coexisting Basal Cell Carcinoma and Squamous Cell Carcinoma in Congenital Nevus Sebaceous". SKIN The Journal of Cutaneous Medicine 2, n. 3 (30 aprile 2018): 181–85. http://dx.doi.org/10.25251/skin.2.3.6.

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Nevus sebaceous is a congenital epidermal hamartoma characterized by hyperplastic changes to the epidermis and adnexa. Nevus sebaceous is associated with an elevated risk of cutaneous neoplasms, most often benign; however, malignant neoplasms, most notably basal cell carcinoma, can also present in these patients. Although a rare occurrence, more often affecting adult patients, squamous cell carcinomas have also been reported to arise at the site of pre-existing nevus sebaceous. Herein we report a unique case of a patient with basal cell carcinoma and squamous cell carcinoma arising concurrently in the same nevus sebaceous.

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Harbold, Jeffery S., Richard G. Wagner e Rick Lin. "Pilomatrical Carcinoma in a 70-Year-Old Hispanic Female". SKIN The Journal of Cutaneous Medicine 4, n. 5 (29 agosto 2020): 460–63. http://dx.doi.org/10.25251/skin.4.5.14.

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Pilomatrical carcinoma is a rare, locally aggressive malignancy of follicular matrix origin. It presents as a rapidly growing, flesh-colored, or blueish, exophytic nodule with tumor asymmetry and poor circumscription. Histological features of these tumors include dominant hyperchromatic basaloid cells with high mitotic rate and nuclear pleomorphism; along with anucleate matrical cells and central necrosis. Pilomatrical carcinomas demonstrate a high rate of recurrence and tendency to metastasize. The most described treatment is wide excision of the tumor with negative margins with or without adjuvant radiation therapy. We present the case of a 70-year-old female patient who presented to the office with a 3-year history of a growing, exophytic lesion on the right nasal ala. A biopsy of the lesion was obtained, and histologic examination was consistent with a diagnosis of pilomatrical carcinoma.

3

Kou, Leon, Austin Wong, Lily Zhong e Sid Danesh. "Cutaneous Metastasis of Thymic Carcinoma to the Frontal Scalp". SKIN The Journal of Cutaneous Medicine 5, n. 4 (9 luglio 2021): 441–44. http://dx.doi.org/10.25251/skin.5.4.20.

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Thymic carcinomas are a rare variant of thymic epithelial tumors. Compared to thymomas, they are much more aggressive, difficult to treat, and have a higher mortality rate. Metastasis outside of the mediastinum is rare and usually to sites such as the lung, lymph nodes, liver, pleura, or bones. We report a case of immunohistochemistry proven thymic carcinoma metastasis to the cutaneous surface of the frontal scalp in a 53-year-old Asian female.

4

Flowers, Lauren, Mandeep Sandhu e Kari Martin. "Skin Cancer". Journal of the Dermatology Nurses' Association 15, n. 6 (26 ottobre 2023): 268–72. http://dx.doi.org/10.1097/jdn.0000000000000764.

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ABSTRACT Basal cell nevus syndrome is a genetically linked multisystem disorder with a hallmark tendency for development of multiple basal cell carcinomas at a young age. It is associated with a multitude of other anomalies including keratocytes of the jaw, palmar or plantar pits, and ectopic intracranial calcifications. This disease is most commonly caused by loss of function in tumor suppressor gene PTCH1 resulting in overactivation of the Hedgehog pathway and basal cell carcinoma formation. Diagnosis is largely clinical; patients must meet criteria of both major and minor categories. Genetic testing is warranted in specific situations where clinical diagnosis is unclear or for genetic counseling purposes. Given that basal cell carcinoma is a very common dermatologic disorder, it is important to recognize when it arises in the setting of genetically associated diseases. Early detection allows for proper management and surveillance of not only basal cell carcinomas but also the other multisystem effects of basal cell nevus syndrome. This review gives an in-depth overview of the etiology, pathogenesis, diagnosis, and management of basal cell nevus syndrome.

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Diaz, Michael, Jasmine Tran, Nicole Natarelli, Akash Sureshkumar e Mahtab Forouzandeh. "Cellular Deconvolution Reveals Unique Findings in Several Cell Type Fractions Within the Basal Cell Carcinoma Tumor Microenvironment". SKIN The Journal of Cutaneous Medicine 7, n. 6 (13 novembre 2023): 1170–73. http://dx.doi.org/10.25251/skin.7.6.15.

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Introduction: Despite therapeutic advancements, locally advanced and metastatic basal cell carcinomas continue to carry poor prognoses and high recurrence rates. Current treatment options remain suboptimal due to limited efficacy and associated adverse events. The objectives of this study are to 1) characterize the basal cell carcinoma immune cell microenvironment and 2) identify novel therapeutic targets. Methods: Transcriptome data representing 25 basal cell carcinoma and 25 control tissue samples were obtained from the Gene Expression Omnibus. Cell type fraction estimates were derived by least-squares deconvolution. Population differences were determined by Mann-Whitney U test. Results: Most significantly, two deconvolution algorithms similarly observed greater B cell infiltration in tumor samples compared to normal tissue (P<0.0001). Conclusion: Importantly, the results of this study provide new insight into the basal cell carcinoma tumor microenvironment and nominate testable immune cell populations for future therapeutic discovery. Study limitations include sample size and applicable background prediction levels of bulk deconvolution tools.

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Owen, Joshua L., Cory Kosche e Jennifer N. Choi. "Verrucous Keratoses Associated with Checkpoint Inhibitor Immunotherapy". SKIN The Journal of Cutaneous Medicine 4, n. 1 (28 gennaio 2020): 64–67. http://dx.doi.org/10.25251/skin.4.1.9.

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Introduction:Checkpoint inhibitor immunotherapy is associated with numerous adverse events, including eruptive keratoacanthomas and squamous cell carcinomas. However, no cases of immunotherapy-associated verrucous keratoses (VKs) have been reported. VKs are proliferative lesions generally considered benign, although they have been suggested to represent premalignant lesions.Cases:We present the first case series of three patients with immunotherapy-associated VKs. The patients were receiving nivolumab for renal cell carcinoma, combination ipilimumab/nivolumab for non-small cell lung carcinoma, and pembrolizumab for malignant melanoma. The VKs appeared 3-7 months after initiation of immunotherapy. Lesions were treated with shave removal or cryosurgery without recurrence. This report adds to the spectrum of cutaneous squamoproliferative lesions induced by checkpoint inhibitor immunotherapy.

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Patel, Jason, Callie Hill, Bonnie Hodge e Carlton Phillips. "Multiple Sebaceous Carcinomas in an African American Patient with Muir-Torre Syndrome". SKIN The Journal of Cutaneous Medicine 6, n. 5 (12 settembre 2022): 398–400. http://dx.doi.org/10.25251/skin.6.5.7.

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Sebaceous carcinoma is a rare, aggressive cutaneous tumor that is known to be associated with Muir-Torre syndrome, an autosomal dominant phenotypic variant of hereditary non-polyposis colorectal cancer or Lynch Syndrome. This case report describes a rare case of multiple sebaceous carcinomas on the back and groin in an African American male in the setting of Muir-Torre syndrome.

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Boularbah, Siham, Sara Elloudi, Sabrina Oujdi, Ghita Gmira, Zakia Douhi, Meryem Soughi, Hanane Bay Bay e Fatima Zahra Mernissi. "Skin cancers of cephalic extremity epidemiology and their anatomical, clinical, therapeutic, and evolutive aspects: A series of 260 cases". Our Dermatology Online 14, n. 4 (1 ottobre 2023): 385–88. http://dx.doi.org/10.7241/ourd.20234.8.

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ABSTRACT Background: The most malignant skin tumors of the head are dominated by epithelial cancers, particularly basal cell carcinomas, followed by squamous cell carcinomas and melanomas. Herein, we present a case series of malignant skin cancers in the cephalic region. We address their epidemiological, clinical, histological, and therapeutic profiles in our context. Materials and Methods: This was a prospective study conducted for descriptive purposes on cases of skin cancer, including melanoma, squamous cell carcinoma, and basal cell carcinoma, followed at the dermatology department of CHU Hassan II Fez between June 2017 and December 2021. Results: We collected a total of 260 patients with different types of skin cancer. 147 cases (57%) were in the cephalic location: 56% presented squamous cell carcinoma, followed by melanoma (22%) and basal cell carcinoma (21%). Conclusion: The early detection of skin cancer is essential to reduce the functional morbidity and mortality associated with these tumors, especially in these cephalic locations. Key words: Cutaneous tumors, Cephalic region, Early diagnosis

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Jain, Sumit, Chetan Singla, Tushar Bhati e Ashutosh Talwar. "Basal Cell Carcinoma on Forearm- A Rare Presentation: A Case Report". SAS Journal of Surgery 9, n. 06 (26 giugno 2023): 601–2. http://dx.doi.org/10.36347/sasjs.2023.v09i06.021.

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Basal cell carcinoma is a type of skin cancer. IT begins in the basal cells — a type of cell within the skin that produces new skin cells as old ones die off. BCC often appears as a slightly transparent bump on the skin. Basal cell carcinoma occurs most often on areas of the skin that are exposed to the sun, such as your head and neck.Most basal cell carcinomas are thought to be caused by long-term exposure to ultraviolet (UV) radiation from sunlight. Avoiding the sun and using sunscreen may help protect against basal cell carcinoma.

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KAJITA, Satoru, Hiroto TERASHI, Mayu MOTOOKA e Shinya TAHARA. "A case of mucinous carcinoma of the skin". Skin Cancer 25, n. 2 (2010): 177–80. http://dx.doi.org/10.5227/skincancer.25.177.

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IIDA, Hideo, Nao KITAMURA, Ryoko SYUKUYA, Takashi YOSHIIKE, Ryo WADA, Kana KONISHI e Takako YAMAAKI. "Two cases of mucinous carcinoma of the skin". Skin Cancer 25, n. 2 (2010): 210–13. http://dx.doi.org/10.5227/skincancer.25.210.

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SATO, Hidetsugu, Seigo HIGASHI, Jun YAMAGUCHI, Kazumi TSUJINO, Shuichi INABA, Takashi YOSHIKAWA, Tsuguo TERAI et al. "Metastatic Skin Carcinoma." JOURNAL OF THE JAPANESE ASSOCIATION OF RURAL MEDICINE 43, n. 4 (1994): 964–68. http://dx.doi.org/10.2185/jjrm.43.964.

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Kaur, Kushaldeep, Amrinder Kaur, Harpal Singh, Shivam Sethi e Harleen Kaur. "Pigmented Squamous Cell Carcinoma of Skin: A Rare Entity". Scholars Journal of Medical Case Reports 12, n. 01 (30 gennaio 2024): 119–22. http://dx.doi.org/10.36347/sjmcr.2024.v12i01.031.

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Squamous cell carcinoma, the second most common form of skin cancer, is caused by the cumulative exposure of skin to UV light. It originates from epidermal keratinocytes or adnexal structures (such as eccrine glands or pilosebaceous units). Squamous cell carcinoma (SCC) has several histologic variants, such as clear cell SCC, signet ring SCC, basaloid SCC, desmoplastic SCC, verrucous and pigmented SCC, among others. Although dendritic melanin containing melanocytes can be seen in a variety of epithelial neoplasms, but only 0.01% to 7% of all squamous cell carcinomas (SCC) are pigmented. Most of which have occurred in the oral and ocular mucosa, with relatively few cases to originate in the skin. The main clinical differential diagnosis for pigmented squamous cell carcinoma are pigmented basal cell carcinoma and melanoma. Herein we report a case of 62 year old male who presented with a blue-black growth over the left inguinal region. Routine lab investigations showed no change and no lymphadenopathy was observed. Biopsy of the growth was received and histopathological evaluation revealed pigmented squamous cell carcinoma. Microscopic examination revealed squamous cell carcinoma with numerous dendritic melanophages showing pigmented melanin. Pigmented SCC can be confused with benign and malignant melanocytic neoplasms, pigmented basal cell carcinoma, actinic keratosis, seborrheic keratosis and pigmented bowen’s disease. In conclusion, this case demonstrates that although pigmented squamous cell carcinomas are relatively rare, they should be included in differential diagnosis of pigmented cutaneous lesions and must be distinguished from other tumors with similar histological findings.

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Claudatus Jr, JC, R. D'Ovidio, M. Lospalluti e CL Meneghini. "Skin tumors and reactive cellular infiltrate: further studies". Acta Dermato-Venereologica 66, n. 1 (1 gennaio 1986): 29–34. http://dx.doi.org/10.2340/00015555662934.

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Twenty-two non-ulcerated basal cell carcinomas and 30 non-ulcerated squamous cell carcinomas were selected to study the reactive cellular infiltrate, utilizing histological, histoenzymatic and immunological methods. Substantial differences in cell behaviour were observed between the two tumors: advanced and metastatic squamous cell carcinoma showed prominent presence of T8+ lymphocytes, Leu 7+ cells, macrophages, mast cells and granulocytes, notably eosinophils. Degranulation of mast cells was seen both in the tumor itself and in the adjacent stroma. The basal cell carcinoma presented a low count of T4+, T8+ lymphocytes, whereas Leu 7+ cells and granulocytes were absent.

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Novice, Taylor Shea, David Oberlin e Chauncey McHargue. "A case of cutaneous metastatic adenosquamous carcinoma of the cervix". SKIN The Journal of Cutaneous Medicine 3, n. 4 (8 luglio 2019): 271–74. http://dx.doi.org/10.25251/skin.3.4.7.

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Introduction:Cutaneous metastasis of cervical carcinoma is very rare, with a reported incidence of .1 to 2%. The adenosquamous carcinoma subtype has been reported the least.3-5 We present a case report of ulceronodular cutaneous metastasis of adenosquamous carcinoma of the cervix.Case Description:A 50-year-old African American female with an eleven-year history of metastatic adenosquamous carcinoma of the cervix presented to the emergency department with an asymptomatic rash in her groin for one-month duration. On physical exam, there were hyperpigmented to violaceous papulonodules across the mons pubis and three ulcerated plaques of the left mons pubis. Punch biopsy was consistent with metastases of cervical adenosquamous carcinoma. No disease specific interventions were taken, and the patient passed away five weeks later.Discussion:Cervical cancer rarely metastasizes to the skin, with a reported incidence of .1 to 2%. Among the subtypes, cutaneous metastasis of cervical adenosquamous carcinoma has been reported the least. In a review of 1185 cases of cervical cancer, Imachi et al found that only 15 cases spread cutaneously, none of which were adenosquamous carcinoma.5 Cutaneous metastases of cervical carcinoma predict a poor prognosis, with an average length of survival of three months.6Our patient developed cutaneous metastases eleven years after diagnosis, which is to our knowledge the longest reported interval from initial diagnosis to development of cutaneous metastases. Although rare, it is important to recognize cutaneous metastases of adenosquamous carcinoma of the cervix as it predicts a poor prognosis and treatment has not been shown to improve outcomes.

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Sidki, Mounia, Maryem Aboudourib, Maryam El Ouazzani, Anass Belbachir, Hanane Rais, Yassine Benchamkha, Ouafa Hocar e Said Amal. "Primary Cutaneous Apocrine Carcinoma: Diagnostic and Management Difficulties of an Uncommon Neoplasm". SKIN The Journal of Cutaneous Medicine 8, n. 3 (13 maggio 2024): 1590–94. http://dx.doi.org/10.25251/skin.8.3.20.

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Primary cutaneous apocrine carcinoma (PCAC) is a rare adnexal neoplasm. Due to its clinical presentation, it can mimic other tumors, especially metastasis. We present a case of primary apocrine carcinoma of the axilla mimicking breast carcinoma metastasis in a 54-year-old woman. The patient presented with a painless, lobed, and erythematous nodule in the left axilla of one year duration. We suspected an adnexal neoplasm but also considered metastasis from breast carcinoma. Histological examination revealed apocrine proliferation. Immunohistochemistry stains of tumor cells were positive for AE1/AE3, and negative for CK7, CK20, p63 and GATA3. Radiological explorations did not reveal any signs of malignancy. Considering all these features, the conclusive diagnosis was primary cutaneous apocrine carcinoma. Treatment was wide excision without adjuvant therapy, and no recurrence was noted. Due to the rarity of this carcinoma, its various clinical presentations, and histological overlaps with breast cancer metastasis, making the diagnosis may be challenging. A comprehensive evaluation of all findings is necessary to rule out other tumors. There is any consensus on the management strategy. The standard treatment is surgical excision, but adjuvant therapies such as radiotherapy or chemotherapy can be proposed in advanced stage disease.

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Faqe Qadir, Chnoor Mohammed, e Karzan Ghafur Khidhir. "Investigating Expression of Skin Basal Cell Carcinoma Molecular Biomarkers". Journal of Zankoy Sulaimani - Part A 22, n. 1 (5 aprile 2020): 265–72. http://dx.doi.org/10.17656/jzs.10791.

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HOMMA, Erina, Satoru AOYAGI, Keiko BABA, Hiroo HATA e Hiroshi SHIMIZU. "A case of primary mucinous carcinoma of the skin". Skin Cancer 26, n. 3 (2011): 348–53. http://dx.doi.org/10.5227/skincancer.26.348.

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NAKAMURA, Hitomi, Toshiaki NAKANO e Hikaru Eto. "A case of primary mucinous carcinoma of the skin". Skin Cancer 28, n. 3 (2014): 340–43. http://dx.doi.org/10.5227/skincancer.28.340.

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Snarskaya, Elena S., L. R. Plieva e I. S. Maximov. "Metatypical basal cell carcinoma in young man". Russian Journal of Skin and Venereal Diseases 19, n. 3 (15 giugno 2016): 132–36. http://dx.doi.org/10.18821/1560-9588-2016-19-3-132-136.

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Malignant epithelial skin tumors are leading among oncological diseases worldwide. In most cases epithelial skin tumors affect areas, susceptible to the action of adverse environmental factors. Metatypical basal cell carcinoma is a variant of basal cell carcinoma that combines the features of basal cell and squamous cell carcinomas. It characterized by infiltrative growth and the destruction of the underlying tissues, pain, bleeding, formation of distant metastases and frequent relapses. Metatypical basal cell carcinoma is more common in women, with the average age is 70.5 years. Historical data, the results of own clinical investigations, rare case of metatypical basal cell carcinoma of the young man, who was successfully treated with recombinant interferon-a2 and prospidinum are presented.

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Krogh, Sara, Mette Bak Nielsen, Linda Skibsted Kornerup e Gitte Dam. "Case of primary low-grade neuroendocrine carcinoma of the skin". BMJ Case Reports 16, n. 12 (dicembre 2023): e257569. http://dx.doi.org/10.1136/bcr-2023-257569.

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A man presents a 4 mm skin tumour at his general practitioner. The tumour is removed on the suspicion of a dermatofibroma. Important differential diagnoses are sebaceous neoplasms, melanomas, Merkel cell carcinomas and large cell neuroendocrine carcinoma, and metastases of neuroendocrine neoplasms from the gut or lung. Immunohistochemical staining excluded sebaceous neoplasm, melanoma and Merkel cell carcinoma, however, was positive for multiple neuroendocrine markers. Relevant scans showed no signs of a primary tumour anywhere else. The final diagnosis was a primary low-grade neuroendocrine carcinoma of the skin. At 30 months follow-up, there was no sign of recurrence.

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Haquang, Joseph, Rocky Li, Kevin Mai, Kuang Cheng Chen, Fardad Sisan e Kuo YuLing. "Epidemiology and Mortality Risk Factors of Sebaceous Carcinoma: A SEER – Based Population Study". SKIN The Journal of Cutaneous Medicine 7, n. 3 (20 maggio 2023): 788–93. http://dx.doi.org/10.25251/skin.7.3.4.

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Background: Sebaceous carcinoma is a rare and potentially aggressive cutaneous malignancy. It is derived from the adnexal epithelium of sebaceous glands and tends to hold a diverse clinical presentation. Although it is often reported in the periocular region, it can manifest from any sebaceous unit in the skin. Due to the rarity of this condition, prognostic and demographic factors are largely indeterminate. Hence, we sought to assess the prognostic impact of demographic and socioeconomic factors on the outcome of patients with sebaceous carcinoma. Methods: A retrospective analysis was performed utilizing data from the Surveillance, Epidemiology, and End Results (SEER) database. From the registries, cases of sebaceous carcinoma from the years 2000 to 2018 were analyzed. Univariate and multivariate cox regression analyses were used to analyze the significance of socioeconomic and demographic factors on the survival of sebaceous carcinoma. Tumor grade and extent were included in the multivariate cox regression to minimize confounding. Results: A total of 4154 cases of sebaceous carcinoma were analyzed within this study. Socioeconomic and demographic factors analyzed includes age, sex, race, and income. On multivariate analysis including tumor grade, tumor extent, age, sex, race and income, African American race was a significant risk indicator for survival (hazard ratio [HR], 1.9; P=.007). Increased age of 70+ were also identified as a significant risk indicator for survival (HR, 5.86; P<0.001). Female sex was identified as a protective indicator for survival (HR, 0.82; P=0.03). Income status did not significantly influence the survival outcome of sebaceous carcinoma. Conclusion: Although income status did not show any significant influence on the survival outcome of sebaceous carcinoma, sex, race, and age characteristics did. The etiology behind these prognostic factors is unclear but may be related to access to medical care or lack of social support.

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Maxi, Margaret Coleman, Joel Byrne, Ardenne Martin e Pamela Martin. "Merkel Cell Carcinoma Presenting as an Indurated Plaque". SKIN The Journal of Cutaneous Medicine 4, n. 6 (27 ottobre 2020): 559–62. http://dx.doi.org/10.25251/skin.4.6.10.

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Merkel Cell Carcinoma (MCC) is a rare and aggressive neuroendocrine carcinoma that most commonly occurs in elderly Caucasian males who have a history of extensive sun exposure. Most cases of Merkel Cell Carcinoma (MCC) present in the outpatient setting and include a single, asymptomatic, red or pink lesion on sun exposed areas with a diameter less than 2 cm. There was a threefold increase in the incidence of MCC from 1986 to 2001, and the incidence of MCC is predicted to continue to increase secondary to the aging “baby boomer” population.To our knowledge, there are only two case reports that describe MCC resembling and receiving the diagnosis of cellulitis at initial presentation. We report an unusual case of MCC presenting as suspected cellulitis of the chest wall in an elderly Caucasian male.

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Abbas, Mariam, e Sunil Kalia. "Trends in Non-Melanoma Skin Cancer (Basal Cell Carcinoma and Squamous Cell Carcinoma) in Canada". Journal of Cutaneous Medicine and Surgery 20, n. 2 (12 ottobre 2015): 166–75. http://dx.doi.org/10.1177/1203475415610106.

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Background: Despite its increased incidence and status as the most prevalent cancer in Canada, there is a paucity of epidemiological data on non-melanoma skin cancer (NMSC). Objective: To assess trends of keratinocyte carcinomas (KC) in Canada over 5 decades. Methods: Articles published from 1960 to 2015 on NMSC in Canada were identified through MEDLINE. Six articles met our search criteria. Results: Overall, KC has increased. However, the rate of increase in the past decade has slowed down and decreased in younger age cohorts. Men had higher incidences of KC. In both sexes, the basal cell carcinoma and squamous cell carcinoma ratio was ≥2.5:1. Keratinocyte carcinomas were most commonly located on the head and neck, and increasing rates are occurring on the trunk. Limitations: The methods of registering skin cancer cases vary among different provinces. Conclusion: Keratinocyte carcinomas incidence is overall increasing; however, there may be evidence that the incidence is leveling off and decreasing in younger age cohorts.

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Thompson, Lester D. R. "Skin basal cell carcinoma". Ear, Nose & Throat Journal 89, n. 9 (settembre 2010): 418–20. http://dx.doi.org/10.1177/014556131008900909.

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Kou, Leon, Lily Zhong e Sid Danesh. "Primary Cutaneous Mucinous Carcinoma of the Nasal Bridge". SKIN The Journal of Cutaneous Medicine 4, n. 6 (27 ottobre 2020): 599–602. http://dx.doi.org/10.25251/skin.4.6.19.

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Mucinous carcinoma is a rare appendage tumor that is resistant to surgery, chemotherapy, and radiotherapy. It has an unremarkable appearance and must be distinguished as a primary tumor or as a metastasis from distant sites. Detailed imaging studies and immunohistochemical investigation are often essential. Here, we report a case of surgery-refractory primary mucinous carcinoma on the left nasal bridge in a 62-year-old female that ultimately required removal by Mohs surgery.

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Onak Kandemir, Nilufer, Figen Barut, Kıvanç Yılmaz, Husnu Tokgoz, Mubin Hosnuter e Sukru Oguz Ozdamar. "Renal Cell Carcinoma Presenting with Cutaneous Metastasis: A Case Report". Case Reports in Medicine 2010 (2010): 1–5. http://dx.doi.org/10.1155/2010/913734.

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Renal cell carcinoma is the most common kidney tumor in adults. Cutaneous metastasis is a rare first symptom of the disease. This paper describes the diagnosis of a renal cell carcinoma that was indicated by cutaneous metastasis in the head and neck region, and considers the etiopathogenesis of such cases. A careful skin examination is important to detect cutaneous metastasis associated with renal cell carcinomas. Metastatic skin lesions in the head and neck region must be taken into consideration during a differential diagnosis.

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Noor, Towhida, Md Shahidullah Sikder, Lubna Khondker, Mohammed Saiful Islam Bhuiyan e Tanvir Rahman. "Behavioral factors associated with the development of skin cancer in patients of arsenicosis". Bangabandhu Sheikh Mujib Medical University Journal 11, n. 2 (27 maggio 2018): 103. http://dx.doi.org/10.3329/bsmmuj.v11i2.35486.

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<p>The study was conducted to evaluate the behavioral factors associated with the development of skin cancer in arsenicosis patients. Arsenicosis patients without skin cancer were taken as control. In the sun-exposed area of the body, 57.2% of skin carcinoma was Bowen’s disease. In the covered area of the body, 56.0% was Bowen’s disease, 36% was squamous cell carcinoma and 8% was basal cell carcinoma. Again, 53.1% of case and 59.4% of control never used fertilizer and pesticide. The majorities were non-smoker (case 53.1%, control 59.3%). Mean cumulative sun exposure was more in the case group (5853.9 ± 2219.7 hours) than in the control group (2219 ± 392.4 hours) and the rate of sun exposure was also higher in the case group. In conclusion, sun exposure was significantly higher in carcinoma patients and since most of the lesions were in the covered areas of the body, it can be said that these carcinomas were due to arsenicosis and not due to sun exposure and smoking status, use of fertilizer and pesticides were not associated with the development of skin carcinoma.</p>

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Shannon, R. L., e D. S. Strayer. "Arsenic-induced Skin Toxicity". Human Toxicology 8, n. 2 (marzo 1989): 99–104. http://dx.doi.org/10.1177/096032718900800203.

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We reviewed available literature on the effects of inorganic arsenic on the skin to determine the potential hazards and to collate information regarding dosage and exposure to the incidence of skin cancer. Arsenic intake may result from occupational or medicinal exposure, or from drinking well water in areas with high arsenic levels in the soil. Arsenic causes a variety of benign skin lesions including hyperpigmentation and hyperkeratosis. Some hyperkeratotic lesions and squamous cell carcinomas in situ may progress to invasive carcinoma; other invasive squamous cell carcinomas will develop de novo. These cutaneous squamous cancers may metastasize; mortality is low, but has been reported. Locally invasive but non-metastasizing basal cell carcinomas may arise as well. These lesions occur in a characteristic pattern of distribution and are usually multiple. Observers reporting medicinally administered arsenic have described dose-response relationships between the amount of arsenic ingested and the frequency of various skin lesions. For arsenic found in drinking water, however, there is more controversy regarding the doses and exposure times necessary for cutaneous toxicity.

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Vasile, Gabriella Francesca, Adam Levin, Raymond Kleinfelder, Daniel Rivlin e Brad Glick. "Renal Cell Carcinoma (RCC) Stain Negative Metastatic Clear Cell Renal Cell Carcinoma Masquerading as a Pyogenic Granuloma on the Scalp". SKIN The Journal of Cutaneous Medicine 4, n. 4 (12 luglio 2020): 345–48. http://dx.doi.org/10.25251/skin.4.4.11.

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Metastasis occurs in 25-50% of patients diagnosed with primary renal cell carcinoma (RCC), although only 6% of RCC metastases manifest on the skin. We present a unique case of a slowly growing clear cell RCC metastasis of the scalp in a middle-aged male that was RCC stain negative. The lesion clinically appeared to be a benign pyogenic granuloma, however, the diagnosis of metastatic clear cell renal cell carcinoma was made based on histology. Because cutaneous metastases may masquerade as other more benign tumors, the physician must be clinically suspicious of vascular appearing lesions on the scalp.

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Onyishi, Nnaemeka T., e Samuel R. Ohayi. "Prevalence of Squamous and Basal Cell Carcinomas in African Albino Skin Cancer Lesions: A Systematic Review and Meta-Analysis of Proportion". Journal of Skin Cancer 2022 (30 agosto 2022): 1–8. http://dx.doi.org/10.1155/2022/5014610.

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Context. Keratinocyte carcinomas are the most common malignant condition in Caucasian populations. African albinos have hypomelanized sensitive skin that is quite susceptible to photocarcinogenesis. Of the keratinocyte carcinomas, squamous cell carcinoma (SCC) has been found more frequent in pigmented Africans, while basal cell carcinoma (BCC) predominates in Caucasians. While some studies report a preponderance of SCC over BCC in African albinos, congruent with the situation in pigmented Africans, other reports have found BCCs to be more frequent and consistent with the pattern in Caucasians. Objective. To estimate the prevalence of cutaneous SCC and BCC in all histologically confirmed skin cancer lesions in African albinos.The following five databases are as follows: African Journals Online (AJOL), PubMed, Europe PMC, and Google Scholar were searched for relevant articles. Study Selection: included studies were case series and cross-sectional studies of histologically confirmed skin cancers in African albinos. Data extraction and synthesis: data extraction and synthesis was informed by the meta-analysis of observational studies in epidemiology guideline. By random effect meta-analysis, we calculated the pooled prevalence of SCC and BCC in skin cancer lesions of the African albinos. Result. We abstracted 695 skin cancer lesions from 540 African albinos (275 male and 241 female albinos with sex not stated in 24 subjects). There were 419 SCCs and 249 BCCs. By meta-analysis, the pooled prevalence of SCC is 64% (95% CI; 50–77%). The prevalence for BCC is 31% (95% CI; 19–45%). Conclusion. Overall, squamous cell carcinoma is the predominant type of keratinocyte carcinoma reported in African albinos. SCC is preponderant in case series of surgical excision biopsies while BCC predominates in studies reporting on albino skin surveillance programmes.

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Sarma, Deba P., Renee B. Dentlinger, Amanda M. Forystek, Todd Stevens e Christopher Huerter. "Poorly Differentiated Squamous Cell Carcinoma Arising in Tattooed Skin". Case Reports in Medicine 2010 (2010): 1–3. http://dx.doi.org/10.1155/2010/431813.

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Introduction. Tattoos have increasingly become accepted by mainstream Western society. As a result, the incidence of tattoo-associated dermatoses is on the rise. The presence of a poorly differentiated squamous cell carcinoma in an old tattooed skin is of interest as it has not been previously documented.Case Presentation. A 79-year-old white homeless man of European descent presented to the dermatology clinic with a painless raised nodule on his left forearm arising in a tattooed area. A biopsy of the lesion revealed a poorly differentiated squamous cell carcinoma infiltrating into a tattoo. The lesion was completely excised and the patient remains disease-free one year later.Conclusion. All previous reports of squamous cell carcinomas arising in tattoos have been well-differentiated low-grade type or keratoacanthoma-type and are considered to be coincidental rather than related to any carcinogenic effect of the tattoo pigments. Tattoo-associated poorly differentiated invasive carcinoma appears to be extremely rare.

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Porter, Hannah, Rebecca Lapides, Keith Morley, Laura Greene e Chin Ho. "Squamous Cell Carcinoma Arising in a Nevus Sebaceus in a 10-Year-Old Male". SKIN The Journal of Cutaneous Medicine 7, n. 6 (13 novembre 2023): 1199–203. http://dx.doi.org/10.25251/skin.7.6.22.

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The patient is a 10-year-old male who presented to a dermatologist regarding a bleeding plaque on the right scalp. The initial pathology report demonstrated an atypical endophytic squamous proliferation with an infiltrative pattern, raising concern for squamous cell carcinoma versus pseudoepitheliomatous hyperplasia. Physical exam showed a painless 4.4 x 1.2 cm elliptical, rough, orange-to-pink plaque with waxy superficial scale on the left forehead. Wide local excision was performed, and pathology confirmed no residual carcinoma. Squamous cell carcinoma arising in a nevus sebaceous in a pediatric patient is exceedingly rare, but as demonstrated by this case, does occur, emphasizing the need for improved guidelines for management to optimize treatment in the pediatric population.

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Iavazzo, C., M. Terzi, P. Arapantoni-Dadioti, V. Dertimas e G. Vorgias. "Vulvar Merkel Carcinoma: A Case Report". Case Reports in Medicine 2011 (2011): 1–2. http://dx.doi.org/10.1155/2011/546972.

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This is a new case of Merkel cell carcinoma of the vulva. It is a rare neuroendocrine carcinoma with an aggressive behavior. Because of its rarity in this location, it is not clear whether it behaves differently from the usual neuroendocrine carcinomas of the skin. A case of a 63-year-old patient with vulvar Merkel carcinoma is presented. The clinical presentation, microscopic and immunohistochemical features, and treatment are discussed.

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Savoia, Paola, Elisa Zavattaro e Ottavio Cremona. "Chemoprevention of Skin Carcinomas in High-Risk Transplant Recipients". Current Medicinal Chemistry 25, n. 6 (21 febbraio 2018): 687–97. http://dx.doi.org/10.2174/0929867324666171003123056.

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Background: Long-term immunosuppressive therapy, as provided to solid organ transplant recipients, inevitably results in a significant inhibition of immune defenses; this leads to frequent skin infections and malignancies, which represent an important cause of morbidity and mortality for transplanted patients. The incidence and risk of skin carcinomas are elevated in solid organ transplant recipients in comparison with the general population, with a 10-fold increased risk for basal cell carcinoma and a 50-100-fold for squamous cell carcinoma. The schedule of immunosuppressive drugs influences the type and timing of skin malignancies, but a crucial role is also played by endogenous and exogenous risk factors. Methods & Results: Here, we will review the state-of-the-art in chemoprevention of epidermal carcinomas in order to provide useful information for clinicians involved in the management of transplant recipients. One-hundred and forteen paper, published on peerreviewed journals, has been included. Conclusion: Chemoprevention would be key in controlling skin carcinogenesis in high-risk patients.

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GUTIÉRREZ-CASTAÑEDA, LUZ DARY, JOHN NOVA e MARÍA IRENE CEREZO-CORTÉS. "Somatic Mutations in TP53 Gene in Colombian Patients With Non-melanoma Skin Cancer". Cancer Diagnosis & Prognosis 2, n. 1 (3 gennaio 2022): 107–14. http://dx.doi.org/10.21873/cdp.10084.

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Background/Aim: Non-melanoma skin cancer is the most common cancer in the world. Somatic mutations in the TP53 gene are associated with the development of this cancer. To describe mutations in exons 5-8 of the TP53 gene in a sample of Colombian patients with non-melanoma skin cancer. Materials and Methods: One hundred and fifteen patients with non-melanoma skin cancer were included. Exons 5-8 were amplified and analyzed by PCR-High Resolution Melting and Sanger sequencing. Results: Fifty-seven patients with basal cell carcinomas and 58 with squamous cell carcinomas were studied. 16% of patients with basal cell carcinoma and 26% of patients with squamous cell carcinoma had mutations in the TP53 gene. The most frequent mutations were substitutions, while three patients had deletions. The most frequent mutation was p.R158G. Conclusion: The analysis showed that Colombian individuals with non-melanoma skin cancer have genetic TP53 variants different from those reported as recurrent for this disease.

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Hope, Landon, Sidra Ibad, Etan Marks, Richard Hope e Clay Cockerell. "Dysmorphic Trichophyton rubrum mimicking Blastomycosis". SKIN The Journal of Cutaneous Medicine 4, n. 2 (8 marzo 2020): 152. http://dx.doi.org/10.25251/skin.4.2.10.

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We will describe a 62 year old immunocompromised, diabetic, male patient who presented with several cutaneous lesions. The patient was 4 years post-nephrectomy due to renal cell carcinoma and 6 months post-renal transplantation at time of presentation. Initial clinical impression was thought to be deep fungal infection or metastatic carcinoma. Trichophyton rubrum with a dysmorphic morphology simulating blastomycosis was ultimately diagnosed.

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Dantal, Jacques, Emmanuel Morelon, Lionel Rostaing, Eric Goffin, Anabelle Brocard, Isabelle Tromme, Nilufer Broeders et al. "Sirolimus for Secondary Prevention of Skin Cancer in Kidney Transplant Recipients: 5-Year Results". Journal of Clinical Oncology 36, n. 25 (1 settembre 2018): 2612–20. http://dx.doi.org/10.1200/jco.2017.76.6691.

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Purpose Transplant recipients who develop cutaneous squamous cell carcinomas are at high risk for multiple subsequent skin cancers. Sirolimus has been shown to reduce the occurrence of secondary skin cancers, but no study included a follow-up exceeding 2 years. We extended at 5 years the TUMORAPA randomized trial of sirolimus-based immunosuppressive regimen versus calcineurin inhibitor–based immunosuppression. Methods Kidney transplant recipients receiving calcineurin inhibitors who had at least one cutaneous squamous cell carcinoma were randomly assigned to receive sirolimus as a substitute for calcineurin inhibitors (n = 64) or to maintain their initial treatment (n = 56). The primary end point was survival free of squamous cell carcinoma at 5 years. Secondary end points included the occurrence of other skin cancers, renal function, patient and graft survival, and treatment tolerance. Results Survival free of cutaneous squamous cell carcinoma was significantly longer in the sirolimus group than in the calcineurin inhibitor group ( P = .007). In the sirolimus group, the number of patients with new skin cancers was significantly lower compared with the calcineurin inhibitor group: 22% versus 59% for squamous cell carcinomas ( P < .001), 34% versus 66% for other skin cancers ( P < .001), and 20% versus 37.5% for basal cell carcinomas ( P < .05). Kidney graft function, patients, and graft survival were similar in both groups. In the sirolimus group, the mean number of serious adverse effects per patient decreased from 1.16 during the first 2 years, to 0.83 between years 2 and 5. Conclusion In kidney transplant recipients with previous cutaneous squamous cell carcinomas, the antitumoral effect of conversion from calcineurin inhibitors to sirolimus was maintained at 5 years, and sirolimus tolerance was satisfactory.

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Koumaki, Dimitra, Georgios Manios, Marios Papadakis, Aikaterini Doxastaki, Georgios Vasileiou Zacharopoulos, Alexander Katoulis e Andreas Manios. "Color Analysis of Merkel Cell Carcinoma: A Comparative Study with Cherry Angiomas, Hemangiomas, Basal Cell Carcinomas, and Squamous Cell Carcinomas". Diagnostics 14, n. 2 (22 gennaio 2024): 230. http://dx.doi.org/10.3390/diagnostics14020230.

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Merkel cell carcinoma (MCC) is recognized as one of the most malignant skin tumors. Its rarity might explain the limited exploration of digital color studies in this area. The objective of this study was to delineate color alterations in MCCs compared to benign lesions resembling MCC, such as cherry angiomas and hemangiomas, along with other non-melanoma skin cancer lesions like basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), utilizing computer-aided digital color analysis. This was a retrospective study where clinical images of the color of the lesion and adjacent normal skin from 11 patients with primary MCC, 11 patients with cherry angiomas, 12 patients with hemangiomas, and 12 patients with BCC/SCC (totaling 46 patients) were analyzed using the RGB (red, green, and blue) and the CIE Lab color system. The Lab color system aided in estimating the Individual Typology Angle (ITA) change in the skin, and these results are documented in this study. It was demonstrated that the estimation of color components can assist in the differential diagnosis of these types of lesions because there were significant differences in color parameters between MCC and other categories of skin lesions such as hemangiomas, common skin carcinomas, and cherry hemangiomas. Significant differences in values were observed in the blue color of RGB (p = 0.003) and the b* parameter of Lab color (p < 0.0001) of MCC versus cherry angiomas. Similarly, the mean a* value of Merkel cell carcinoma (MCC) compared to basal cell carcinoma and squamous cell carcinoma showed a statistically significant difference (p < 0.0001). Larger prospective studies are warranted to further validate the clinical application of these findings.

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Adhikari, Ram Chandra, Mahesh Shah e Anil Kumar Jha. "Histopathological pattern of skin cancer at tertiary referral skin health centre". Journal of Pathology of Nepal 9, n. 2 (29 settembre 2019): 1555–59. http://dx.doi.org/10.3126/jpn.v9i2.25827.

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Background: The skin is a heterogeneous organ, capable of producing various types of skin tumors. The incidence of skin cancers, including melanoma and non-melanoma has been reported to have risen in many parts of the world. In Asian and African countries, individuals with pigmented races have a much lower incidence of skin cancers despite sunny hot weather. This study is aimed to analyze age, sex and site wise of distribution of skin cancers. Materials and Methods: The study included a total of 60 patients with histopathologically proven skin cancers from January 2015 to December 2018 in the department of pathology, DI skin health and referral centre, Kathmandu, Nepal. Results: A total of 60 cases of histopathologically proven skin cancer constituted 3.69% of total skin biopsies. Patient age ranged from 15 to 88 years with mean age being 61 years. The majority of the patients were in the age group of 61-70 yrs. The male to female ratio is 1:1.3. Basal cell carcinoma was the most common skin cancer constituting 43.4%, followed by squamous cell carcinoma (28.3%). The most common site of skin cancer is head & neck (73.3%), followed by lower extremities (8.3%). Other skin cancers were Bowen’s disease, melanoma, verrucous carcinoma, keratoacanthoma, trichilemmal carcinoma, extramammary Paget’s disease, Non-Hodgkin lymphoma and metastatic tumor. Conclusions: The most common type of skin cancer is basal cell carcinoma, followed by squamous cell carcinoma and head & neck being the commonest site.

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Kuraitis, Drew, Yong Lee, Abida Kadi e Andrea Murina. "Eccrine Porocarcinoma Masquerading as Squamous Cell Carcinoma". SKIN The Journal of Cutaneous Medicine 4, n. 6 (27 ottobre 2020): 620–22. http://dx.doi.org/10.25251/skin.4.6.24.

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Schoen, M. W., P. S. Gable e A. M. Reese. "Increased incidence of non-melanomatous skin cancer in patients with chronic lymphocytic leukemia, an 11-year case-control study". Journal of Clinical Oncology 25, n. 18_suppl (20 giugno 2007): 19554. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.19554.

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19554 Background: Chronic Lymphocytic Leukemia (CLL) is a disease of B lymphocytes that affects immune tolerance and surveillance. Patients with CLL have an increased risk of basal and squamous cell skin carcinomas, which tend to be aggressive. We report the incidence of non-melanomatous (NM) in a >80% Caucasian cohort of patients with CLL and compared them to normal controls who reside in Southern California. Methods: A retrospective review was conducted of all patients in the Naval Medical Center San Diego tumor registry with CLL diagnosed between Jan 1, 1995 and Dec 31, 2005. The electronic records of 74 CLL patients and 100 control patients from the internal medicine clinic were assessed for skin biopsies performed at our institution revealing NM skin malignancies. Results: Within our CLL population, the average age at diagnosis was 72.2 years. 34% (25/74) had NM skin cancer with an incidence of 11,457 NM skin cancers per 100,000 person-years. The average number of malignant lesions was 3.7 per patient with one patient receiving 17 biopsies. 27% (7/25) of CLL patients with NM skin cancer had only squamous cell carcinoma and 23% (6/25) had only basal cell carcinoma. 42% (11/25) of patients had both squamous and basal cell cancers and one had a Merkel cell carcinoma. In the control population, the average age at diagnosis was 76.4 years. 16% (16/100) had NM skin malignancies with an incidence of 5,333 NM skin cancers per 100,000 person-years. The average number of malignant lesions was 3.7 per patient with one patient receiving 28 biopsies. 63% (10/16) had basal cell carcinomas, only 25% (4/16) had squamous cell carcinomas and 13% (2/16) had both types of cancer. Conclusions: Patients with CLL are at increased risk of developing NM skin cancers, especially squamous cell carcinomas. Patients with CLL have a 2.1 times higher risk of developing NM skin cancer than our control population, who had an incredibly high rate of skin cancer compared to prior publications. CLL patients should be closely screened for cutaneous malignancies in order to excise them before they cause further morbidity. Increased surveillance is especially prudent for elderly patients with fair skin types who have been exposed to a large amount of UV-light. No significant financial relationships to disclose.

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Ninan, Jiby Soosen, Ajithakumari K. e Tony Mathew. "Primary Cutaneous Mucinous Carcinoma Presenting as an Unusually Large Lesion - A Rare Case Report". Journal of Evolution of Medical and Dental Sciences 10, n. 34 (23 agosto 2021): 2939–41. http://dx.doi.org/10.14260/jemds/2021/599.

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Primary cutaneous mucinous carcinoma (PCMC) also known as primary mucinous carcinoma of the skin (PMCS) or primary mucinous eccrine carcinoma (PMEC) is a rare malignant adnexal tumour of eccrine origin. Many visceral mucinous carcinomas especially of the breast and gastrointestinal tract can metastasize to the skin mimicking PCMC. Hence it is very important to rule out metastatic mucinous carcinomas before making a diagnosis of PCMC. Usually, PCMC presents as a slowgrowing tumour of considerably smaller size compared to our case. The large size and shorter duration are the key features of this case report. Here we report an unusually large-sized rare malignant tumour of skin appendage. Our patient was a 54-year-old lady who presented with progressive swelling of one year duration in the right frontoparietal area. Ultrasonography showed an ill-defined lesion in the subcutaneous plane with multiple cystic spaces within it. No bone involvement was noted. The excised lesion measured 13 x 7 x 2 cms and was diagnosed as primary cutaneous mucinous carcinoma on histopathological examination. The possibility of cutaneous secondaries from elsewhere was ruled out by detailed clinical and radiological investigations. The case is reported considering the unusually bigger size and shorter duration of this rare entity.

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Kadam, Sameer Arun, Kirti G. Pardeshi, Hoogar Mallinath Basalingappa, Satish Bhasale, Vaishali Bhonsle, Nakul Sampat e Arvind Valand. "Multiple-lesion, non-familial basal cell carcinoma-An interesting oddity". IP Journal of Diagnostic Pathology and Oncology 8, n. 4 (15 dicembre 2023): 225–29. http://dx.doi.org/10.18231/j.jdpo.2023.053.

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Basal cell carcinoma (BCC) is the most common primary carcinoma of skin, which accounts for three-fourth of all primary skin tumours. Basal carcinoma occurs commonly as a single lesion, though occasionally it can occur as Multiple lesions, which may occur in close association with heredofamilial conditions such as nevoid basal cell carcinoma syndrome (Gorlin’s syndrome), Bazex syndrome, Rombo syndrome, and unilateral basal cell nevus syndrome. The case of multiple basal cell carcinomas being presented here is unique in its occurrence inasmuch as it is not associated with heredofamilial conditions, and despite not being associated with heredofamilial conditions there is occurrence of multiple basal carcinomas in a patient in a tertiary care hospital in a dominantly tribal region. The patient has no family history of genodermatosis that could increase the incidence of multiple basal cell carcinomas such as xeroderma pigmentosum, and no history of other predisposing conditions including actinic keratosis, Bowen’s Disease, leukoplakia, Erythroplasia of Queyrat, keratoacanthoma, radiation dermatitis and exposure to arsenicals, psoralen and other photosensitizing medications. However, the patient had history of having raised macules over the face which were diagnosed as seborrheic keratosis.

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CHAKRABARTI, I., J. D. WATSON e H. DORRANCE. "Skin Tumours of the Hand". Journal of Hand Surgery 18, n. 4 (agosto 1993): 484–86. http://dx.doi.org/10.1016/0266-7681(93)90153-7.

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A 10-year retrospective study was performed in order to determine the incidence, distribution, histological type and behaviour of skin tumours of the hand that were referred to a regional Plastic Surgery unit. 85 patients were studied and 98 malignant or pre-malignant lesions identified. The majority were squamous cell carcinomas in male manual workers. Recurrence after excision was seen only in lesions greater than 1.5 cm in diameter. The overall incidence of squamous cell carcinoma of the hand (requiring surgical excision) was seen to be five cases per million per year. Other skin tumours were rare.

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Hall, Kathryn, e Adrian Guevara. "Development of Multiple Facial Lipomas During Immunotherapy for Metastatic Squamous Cell Carcinoma". SKIN The Journal of Cutaneous Medicine 7, n. 6 (13 novembre 2023): 1195–98. http://dx.doi.org/10.25251/skin.7.6.21.

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An 85-year-old Caucasian male on immunotherapy for metastatic squamous cell carcinoma presented with enlarging lipomas in the area of his previous invasive squamous cell carcinoma of the lower lip and chin, status post resection, reconstruction and local radiation. The development of multiple lipomas during immunotherapy is a novel association which has yet to be reported in the literature. We discuss a putative mechanism of action of pembrolizumab-induced lipomas and describe the patient's clinical course.

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Wilken, Reason, John Carucci e Mary L. Stevenson. "Skin Cancers and Lung Transplant". Seminars in Respiratory and Critical Care Medicine 42, n. 03 (24 maggio 2021): 483–96. http://dx.doi.org/10.1055/s-0041-1728798.

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AbstractIt is well known that solid-organ transplant recipients (SOTRs) have a 65- to 100-fold increase in the risk of developing skin cancer, namely, nonmelanoma skin cancers (NMSCs) such as cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC). In addition, these patients are also at increased risk for development of melanoma as well as other less common cutaneous malignancies (Merkel's cell carcinoma, Kaposi's sarcoma). SOTRs with NMSC (namely cSCC) are also at significantly increased risk of poor clinical outcomes including local recurrence, nodal and distant metastasis, and disease-specific death relative to patients who are not immunosuppressed. Increased surveillance and monitoring in patients at risk of aggressive disease and poor outcomes who are on immunosuppression is essential in patients with lung transplants given the high degree of immunosuppression. Increased awareness of risks, treatments, and management allows for improved outcomes in these patients. This article will provide an overview of the risk factors for the development of cutaneous malignancies in organ transplant recipients as well as a detailed discussion of various immunosuppressant and prophylactic medications used in this patient population that contribute to the risk of developing cutaneous malignancies, with an emphasis on NMSC (cSCC and BCC) in lung transplant recipients. Finally, this article includes a discussion on the clinical and dermatologic management of this high-risk immunosuppressed population including a review of topical and systemic agents for field therapy of actinic damage and chemoprevention of keratinocyte carcinomas. In addition, indications for additional treatment and preventive measures such as adjuvant radiation treatment after surgical management of cutaneous malignancies and potential modification of immunosuppressive medication regimens are discussed.

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Soni, Monica, Sudesh Aggarwal, Prasoon Soni, Puja Gupta, Shaifali Dadhich e Sharadlata Saini. "Vulvar Merkel Cell Carcinoma: A Rare Entity". Journal of South Asian Federation of Obstetrics and Gynaecology 3, n. 3 (2011): 145–46. http://dx.doi.org/10.5005/jp-journals-10006-1153.

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ABSTRACT Merkel cell carcinoma is a primary small cell carcinoma of the skin that resembles oat cell carcinomas of the lung. This tumor has a predilection for head and neck region but may rarely occur as isolated vulvar tumor. It has aggressive malignant behavior and should not be missed while evaluating vulvar masses. We report a case of 45-year-old Mrs I, who presented with recurrent vulvar swelling and was diagnosed as stage III Merkel cell carcinoma of the vulva. Synonyms Primary neuroendocrine carcinoma, Trabecular carcinoma, Primary small cell carcinoma, Cutaneous apudoma.

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Lee, Myn Wee, George Varigos, Peter Foley e Gayle Ross. "Photodynamic Therapy for Basal Cell Carcinoma in Recessive Dystrophic Epidermolysis Bullosa". ISRN Dermatology 2011 (27 aprile 2011): 1–4. http://dx.doi.org/10.5402/2011/346754.

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A 22-year-old male with recessive dystrophic epidermolysis bullosa with a large superficial and nodular basal cell carcinoma on his right forehead was treated with photodynamic therapy. The treatment was well tolerated, and the site healed well. Patients with epidermolysis bullosa are at increased risk of developing skin cancers, particularly squamous cell carcinomas. However, basal cell carcinomas are rare in recessive dystrophic epidermolysis bullosa. As patients with epidermolysis bullosa have recurrent blistering and poor wound healing, surgery may not be the optimal choice in treating skin cancers. We present this case to highlight that photodynamic therapy may be a helpful and safe technique in the treatment of superficial skin cancers in patients with epidermolysis bullosa, as an alternative to more radical methods.

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Smith, Paula D., e James W. Patterson. "Merkel Cell Carcinoma (Neuroendocrine Carcinoma of the Skin)". Pathology Patterns Reviews 115, suppl_1 (1 giugno 2001): S68—S78. http://dx.doi.org/10.1309/mvxr-8bm1-gpr7-p5np.

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