Articoli di riviste: "Silica nanochannel"

1

Zucchetto, Nicola, e Dominik Brühwiler. "Tuning the aspect ratio of arrays of silica nanochannels". RSC Advances 5, n. 91 (2015): 74638–44. http://dx.doi.org/10.1039/c5ra16913e.

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Morikawa, Kyojiro, Yutaka Kazoe, Yuto Takagi, Yoshiyuki Tsuyama, Yuriy Pihosh, Takehiko Tsukahara e Takehiko Kitamori. "Advanced Top-Down Fabrication for a Fused Silica Nanofluidic Device". Micromachines 11, n. 11 (9 novembre 2020): 995. http://dx.doi.org/10.3390/mi11110995.

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Abstract (sommario):

Nanofluidics have recently attracted significant attention with regard to the development of new functionalities and applications, and producing new functional devices utilizing nanofluidics will require the fabrication of nanochannels. Fused silica nanofluidic devices fabricated by top-down methods are a promising approach to realizing this goal. Our group previously demonstrated the analysis of a living single cell using such a device, incorporating nanochannels having different sizes (102–103 nm) and with branched and confluent structures and surface patterning. However, fabrication of geometrically-controlled nanochannels on the 101 nm size scale by top-down methods on a fused silica substrate, and the fabrication of micro-nano interfaces on a single substrate, remain challenging. In the present study, the smallest-ever square nanochannels (with a size of 50 nm) were fabricated on fused silica substrates by optimizing the electron beam exposure time, and the absence of channel breaks was confirmed by streaming current measurements. In addition, micro-nano interfaces between 103 nm nanochannels and 101 μm microchannels were fabricated on a single substrate by controlling the hydrophobicity of the nanochannel surfaces. A micro-nano interface for a single cell analysis device, in which a nanochannel was connected to a 101 μm single cell chamber, was also fabricated. These new fabrication procedures are expected to advance the basic technologies employed in the field of nanofluidics.

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Chen, Gengbiao, e Zhiwen Liu. "Effect of Hydrophobic Silica Nanochannel Structure on the Running Speed of a Colloidal Damper". Applied Sciences 11, n. 15 (24 luglio 2021): 6808. http://dx.doi.org/10.3390/app11156808.

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A colloidal damper (CD) can dissipate a significant amount of vibrations and impact energy owing to the interface power that is generated when it is used. It is of great practical significance to study the influence of the nanochannel structure of hydrophobic silica gel in the CD damping medium on the running speed of the CD. The fractal theory was applied to observe the characteristics of the micropore structure of the hydrophobic silica gel by scanning electron microscopy (SEM), the primary particles were selected to carry out fractal analysis, and the two-dimensional fractal dimension of the pore area and the tortuous fractal dimension of the hydrophobic silica gel pore structure were calculated. The fractal percolation model of water in hydrophobic silica nanochannels based on the slip theory could thus be obtained. This model revealed the relationship between the micropore structure parameters of the silica gel and the running speed of the CD. The CD running speed increases with the addition of grafted molecules and the reduction in pore size of the silica gel particles. Continuous loading velocity testing of the CD loaded with hydrophobic silica gels with different pore structures was conducted. By comparing the experimental results with the calculation results of the fractal percolation model, it was determined that the fractal percolation model can better characterize the change trend of the CD running velocity for the first loading, but the fractal dimension was changed from the second loading, caused by the small amount of water retained in the nanochannel, leading to the failure of fractal characterization.

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Sokolov, I., V. Kalaparthi, D. O. Volkov, S. Palantavida, N. E. Mordvinova, O. I. Lebedev e J. Owens. "Control and formation mechanism of extended nanochannel geometry in colloidal mesoporous silica particles". Physical Chemistry Chemical Physics 19, n. 2 (2017): 1115–21. http://dx.doi.org/10.1039/c6cp07057d.

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Fernández, Iñigo, Alfredo Sánchez, Paula Díez, Paloma Martínez-Ruiz, Prospero Di Pierro, Raffaele Porta, Reynaldo Villalonga e José M. Pingarrón. "Nanochannel-based electrochemical assay for transglutaminase activity". Chem. Commun. 50, n. 87 (2014): 13356–58. http://dx.doi.org/10.1039/c4cc05083e.

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Yang, Qian, Xingyu Lin, Yafeng Wang e Bin Su. "Nanochannels as molecular check valves". Nanoscale 9, n. 46 (2017): 18523–28. http://dx.doi.org/10.1039/c7nr05924h.

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Yan, Fei, Jie Chen, Qifan Jin, Huaxu Zhou, Ajabkhan Sailjoi, Jiyang Liu e Weizhong Tang. "Fast one-step fabrication of a vertically-ordered mesoporous silica-nanochannel film on graphene for direct and sensitive detection of doxorubicin in human whole blood". Journal of Materials Chemistry C 8, n. 21 (2020): 7113–19. http://dx.doi.org/10.1039/d0tc00744g.

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Zhang, Wenfei, e Dongqing Li. "Low speed water flow in silica nanochannel". Chemical Physics Letters 450, n. 4-6 (gennaio 2008): 422–25. http://dx.doi.org/10.1016/j.cplett.2007.11.043.

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Ding, Jialian, Xinru Li, Lin Zhou, Rongjie Yang, Fei Yan e Bin Su. "Electrodeposition of nickel nanostructures using silica nanochannels as confinement for low-fouling enzyme-free glucose detection". Journal of Materials Chemistry B 8, n. 16 (2020): 3616–22. http://dx.doi.org/10.1039/c9tb02472g.

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Morikawa, Kyojiro, Ryoichi Ohta, Kazuma Mawatari e Takehiko Kitamori. "Metal-Free Fabrication of Fused Silica Extended Nanofluidic Channel to Remove Artifacts in Chemical Analysis". Micromachines 12, n. 8 (31 luglio 2021): 917. http://dx.doi.org/10.3390/mi12080917.

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Abstract (sommario):

In microfluidics, especially in nanofluidics, nanochannels with functionalized surfaces have recently attracted attention for use as a new tool for the investigation of chemical reaction fields. Molecules handled in the reaction field can reach the single–molecule level due to the small size of the nanochannel. In such surroundings, contamination of the channel surface should be removed at the single–molecule level. In this study, it was assumed that metal materials could contaminate the nanochannels during the fabrication processes; therefore, we aimed to develop metal-free fabrication processes. Fused silica channels 1000 nm-deep were conventionally fabricated using a chromium mask. Instead of chromium, electron beam resists more than 1000 nm thick were used and the lithography conditions were optimized. From the results of optimization, channels with 1000 nm scale width and depth were fabricated on fused silica substrates without the use of a chromium mask. In nanofluidic experiments, an oxidation reaction was observed in a device fabricated by conventional fabrication processes using a chromium mask. It was found that Cr6+ remained on the channel surfaces and reacted with chemicals in the liquid phase in the extended nanochannels; this effect occurred at least to the micromolar level. In contrast, the device fabricated with metal-free processes was free of artifacts induced by the presence of chromium. The developed fabrication processes and results of this study will be a significant contribution to the fundamental technologies employed in the fields of microfluidics and nanofluidics.

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Liu, Bing, Xiaoqi Li, Chao Qi, Tingyi Mai, Kaiyun Zhan, Li Zhao e Yue Shen. "Pressure-driven supercritical CO2 transport through a silica nanochannel". RSC Advances 8, n. 3 (2018): 1461–68. http://dx.doi.org/10.1039/c7ra11746a.

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Shiohara, Amane, Christopher D. Easton, Beatriz Prieto-Simon e Nicolas H. Voelcker. "Electrochemical Biosensors Based on Convectively Assembled Colloidal Crystals". Biosensors 12, n. 7 (30 giugno 2022): 480. http://dx.doi.org/10.3390/bios12070480.

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Rapid, sensitive, selective and portable virus detection is in high demand globally. However, differentiating non-infectious viral particles from intact/infectious viruses is still a rarely satisfied sensing requirement. Using the negative space within monolayers of polystyrene (PS) spheres deposited directly on gold electrodes, we fabricated tuneable nanochannels decorated with target-selective bioreceptors that facilitate the size-selective detection of intact viruses. Detection occurred through selective nanochannel blockage of diffusion of a redox probe, [Fe(CN)6]3/4−, allowing a quantifiable change in the oxidation current before and after analyte binding to the bioreceptor immobilised on the spheres. Our model system involved partial surface passivation of the mono-assembled PS spheres, by silica glancing angle deposition, to confine bioreceptor immobilisation specifically to the channels and improve particle detection sensitivity. Virus detection was first optimised and modelled with biotinylated gold nanoparticles, recognised by streptavidin immobilised on the PS layer, reaching a low limit of detection of 37 particles/mL. Intact, label-free virus detection was demonstrated using MS2 bacteriophage (~23–28 nm), a marker of microbiological contamination, showing an excellent limit of detection of ~1.0 pfu/mL. Tuneable nanochannel geometries constructed directly on sensing electrodes offer label-free, sensitive, and cost-efficient point-of-care biosensing platforms that could be applied for a wide range of viruses.

13

Zhou, Yucheng, Hongxin Wang, Fengna Xi e Chao Lu. "Sensitive Electrochemical Detection of Carcinoembryonic Antigen Based on Biofunctionalized Nanochannel Modified Carbonaceous Electrode". Molecules 29, n. 4 (15 febbraio 2024): 858. http://dx.doi.org/10.3390/molecules29040858.

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The convenient construction of carbon-based electrochemical immunosensors with high performance is highly desirable for the efficient detection of tumor biomarkers. In this work, an electrochemical immunosensor was fabricated by integrating a biofunctionalized mesoporous silica nanochannel film with a carbon-based electrode, which can enable the sensitive determination of carcinoembryonic antigen (CEA) in serum. The commonly used carbonaceous electrode, glassy carbon electrode (GCE), was employed as the supporting electrode and was pre-treated through electrochemical polarization to achieve the stable binding of a vertically ordered mesoporous silica film with amino groups (NH2-VMSF) without the use of any adhesive layer. To fabricate the immunorecognition interface, antibodies were covalently immobilized after the amino groups on the outer surface of NH2-VMSF was derivatized to aldehyde groups. The presence of amino sites within the high-density nanochannels of NH2-VMSF can facilitate the migration of negatively charged redox probes (Fe(CN)63-/4-) to the supporting electrode through electrostatic adsorption, leading to the generation of electrochemical signals. In the presence of CEA, the formation of immunocomplexes on the recognitive interface can reduce the electrochemical signal of Fe(CN)63-/4- on the supporting electrode. Based on this principle, the sensitive electrochemical detection of CEA was achieved. CEA can be determined to range from 0.01 ng mL−1 to 100 ng mL−1 with a limit of detection of 6.3 pg mL−1. The fabricated immunosensor exhibited high selectivity, and the detection of CEA in fetal bovine serum was achieved.

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Liu, Yue, Ping Li, Li Xie, Dingyan Fan e Shasheng Huang. "β-cyclodextrin modified silica nanochannel membrane for chiral separation". Journal of Membrane Science 453 (marzo 2014): 12–17. http://dx.doi.org/10.1016/j.memsci.2013.10.064.

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Giussani, Lara, Gloria Tabacchi, Salvatore Coluccia e Ettore Fois. "Confining a Protein-Containing Water Nanodroplet inside Silica Nanochannels". International Journal of Molecular Sciences 20, n. 12 (18 giugno 2019): 2965. http://dx.doi.org/10.3390/ijms20122965.

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Incorporation of biological systems in water nanodroplets has recently emerged as a new frontier to investigate structural changes of biomolecules, with perspective applications in ultra-fast drug delivery. We report on the molecular dynamics of the digestive protein Pepsin subjected to a double confinement. The double confinement stemmed from embedding the protein inside a water nanodroplet, which in turn was caged in a nanochannel mimicking the mesoporous silica SBA-15. The nano-bio-droplet, whose size fits with the pore diameter, behaved differently depending on the protonation state of the pore surface silanols. Neutral channel sections allowed for the droplet to flow, while deprotonated sections acted as anchoring piers for the droplet. Inside the droplet, the protein, not directly bonded to the surface, showed a behavior similar to that reported for bulk water solutions, indicating that double confinement should not alter its catalytic activity. Our results suggest that nanobiodroplets, recently fabricated in volatile environments, can be encapsulated and stored in mesoporous silicas.

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Yan, Liang, Shuai Xu e Fengna Xi. "Disposal Immunosensor for Sensitive Electrochemical Detection of Prostate-Specific Antigen Based on Amino-Rich Nanochannels Array-Modified Patterned Indium Tin Oxide Electrode". Nanomaterials 12, n. 21 (28 ottobre 2022): 3810. http://dx.doi.org/10.3390/nano12213810.

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Sensitive detection of prostate-specific antigens (PSA) in serum is essential for the prevention and early treatment of prostate cancer. Simple and disposable electrochemical immunosensors are highly desirable for screening and mobile detection of PSAs in high-risk populations. Here, an electrochemical immunosensor was constructed based on amino-rich nanochannels array-modified patterned, inexpensive, and disposable indium tin oxide (ITO) electrodes, which can be employed for the sensitive detection of PSA. Using an amino-group-containing precursor, a vertically ordered mesoporous silica nanochannel film (VMSF) containing amino groups (NH2-VMSF) was rapidly grown on ITO. When NH2-VMSF contained template surfactant micelle (SM), the outer surface of NH2-VMSF was directionally modified by aldehyde groups, which enabled further covalent immobilization of the recognitive antibody to prepare the immuno-recognitive interface. Owing to the charge-based selective permeability, NH2-VMSF can electrostatically adsorb negatively charged redox probes in solution (Fe(CN)63−/4−). The electrochemical detection of PSA is realized based on the mechanism that the antigen–antibody complex can reduce the diffusion of redox probes in solution to the underlying electrode, leading to the decrease in electrochemical signal. The constructed immunosensor can achieve sensitive detection of PSA in the range from 10 pg/mL to 1 μg/mL with a limit of detection (LOD) of 8.1 pg/mL. Sensitive detection of PSA in human serum was also achieved. The proposed disposable immunosensor based on cheap electrode and nanochannel array is expected to provide a new idea for developing a universal immunosensing platform for sensitive detection of tumor markers.

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Yan, Zhengzheng, Shiyue Zhang, Jiyang Liu e Jun Xing. "Homogeneous Electrochemical Aptamer Sensor Based on Two-Dimensional Nanocomposite Probe and Nanochannel Modified Electrode for Sensitive Detection of Carcinoembryonic Antigen". Molecules 28, n. 13 (3 luglio 2023): 5186. http://dx.doi.org/10.3390/molecules28135186.

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A rapid and convenient homogeneous aptamer sensor with high sensitivity is highly desirable for the electrochemical detection of tumor biomarkers. In this work, a homogeneous electrochemical aptamer sensor is demonstrated based on a two-dimensional (2D) nanocomposite probe and nanochannel modified electrode, which can realize sensitive detection of carcinoembryonic antigen (CEA). Using π-π stacking and electrostatic interaction, CEA aptamer (Apt) and cationic redox probe (hexaammineruthenium(III), Ru(NH3)63+) are co-loaded on graphite oxide (GO), leading to a 2D nanocomposite probe (Ru(NH3)63+/Apt@GO). Vertically ordered mesoporous silica-nanochannel film (VMSF) is easily grown on the supporting indium tin oxide (ITO) electrode (VMSF/ITO) using the electrochemical assisted self-assembly (EASA) method within 10 s. The ultrasmall nanochannels of VMSF exhibits electrostatic enrichment towards Ru(NH3)63+ and size exclusion towards 2D material. When CEA is added in the Ru(NH3)63+/Apt@GO solution, DNA aptamer recognizes and binds to CEA and Ru(NH3)63+ releases to the solution, which can be enriched and detected by VMSF/ITO electrodes. Based on this mechanism, CEA can be an electrochemical detection ranging from 60 fg/mL to 100 ng/mL with a limit of detection (LOD) of 14 fg/mL. Detection of CEA in human serum is also realized. The constructed homogeneous detection system does not require the fixation of a recognitive aptamer on the electrode surface or magnetic separation before detection, demonstrating potential applications in rapid, convenient and sensitive electrochemical sensing of tumor biomarkers.

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Li, Feng, Qianqian Han e Fengna Xi. "The Fabrication of a Probe-Integrated Electrochemiluminescence Aptasensor Based on Double-Layered Nanochannel Array with Opposite Charges for the Sensitive Determination of C-Reactive Protein". Molecules 28, n. 23 (30 novembre 2023): 7867. http://dx.doi.org/10.3390/molecules28237867.

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The effective and sensitive detection of the important biomarker, C-reactive protein (CRP), is of great significance in clinical diagnosis. The development of a convenient and highly sensitive electrochemiluminescence (ECL) aptasensor with an immobilized emitter probe is highly desirable. In this work, a probe-integrated ECL aptamer sensor was constructed based on a bipolar silica nanochannel film (bp-SNF) modified electrode for the highly sensitive ECL detection of CRP. The bp-SNF, modified on an ITO electrode, consisted of a dual-layered SNF film, including the negatively charged inner SNF (n-SNF) and the outer SNF with a positive charge and amino groups (p-SNF). The ECL emitter, tris(bipyridine) ruthenium (II) (Ru(bpy)32+), was stably immobilized in a nanochannel of bp-SNF using the dual electrostatic interactions with n-SNF attracting and p-SNF repelling. The amino groups on the outer surface of bp-SNF were aldehyde derivatized, allowing for the covalent immobilization of recognitive aptamers (5′-NH2-CGAAGGGGATTCGAGGGGTGATTGCGTGCTCCATTTGGTG-3′), leading to the recognition interface. When CRP bound to the aptamer on the recognition interface, the formed complex increased the interface resistance and reduced the diffusion of the co-reactant tripropylamine (TPA) into the nanochannels, leading to a decrease in the ECL signal. Based on this mechanism, the constructed aptamer sensor could achieve a sensitive ECL detection of CRP ranging from 0.01 to 1000 ng/mL, with a detection limit (DL) of 8.5 pg/mL. The method for constructing this probe-integrated ECL aptamer sensor is simple, and it offers a high probe stability, good selectivity, and high sensitivity.

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Zhao, Meijiao, Wanhao Wu e Bin Su. "pH-Controlled Drug Release by Diffusion through Silica Nanochannel Membranes". ACS Applied Materials & Interfaces 10, n. 40 (13 settembre 2018): 33986–92. http://dx.doi.org/10.1021/acsami.8b12200.

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Ma, Ning, Shuai Xu, Weidong Wu e Jiyang Liu. "Electrochemiluminescence Aptasensor with Dual Signal Amplification by Silica Nanochannel-Based Confinement Effect on Nanocatalyst and Efficient Emitter Enrichment for Highly Sensitive Detection of C-Reactive Protein". Molecules 28, n. 22 (19 novembre 2023): 7664. http://dx.doi.org/10.3390/molecules28227664.

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The rapid and sensitive detection of the important biomarker C-reactive protein (CRP) is of great significance for monitoring inflammation and tissue damage. In this work, an electrochemiluminescence (ECL) aptasensor was fabricated based on dual signal amplification for the sensitive detection of CRP in serum samples. The sensor was constructed by modifying a silica nanochannel array film (SNF) on a cost-effective indium tin oxide (ITO) electrode using the Stöber solution growth method. Gold nanoparticles (AuNPs) were grown in situ within the nanochannels using a simple electrodeposition method as a nanocatalyst to enhance the active electrode area as well as the ECL signal. The negatively charged nanochannels also significantly enriched the positively charged ECL emitters, further amplifying the signal. The recognition aptamer was covalently immobilized on the outer surface of SNF after modification with epoxy groups, constructing the aptasensor. In the presence of CRP, the formation of complexes on the recognitive interface led to a decrease in the diffusion of ECL emitters and co-reactants to the supporting electrode, resulting in a reduction in the ECL signal. Based on this mechanism, ECL detection of CRP was achieved with a linear range of 10 pg/mL to 1 μg/mL and a low limit of detection (7.4 pg/mL). The ECL aptasensor developed in this study offers advantages such as simple fabrication and high sensitivity, making promising applications in biomarker detection.

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Syukri, Rycce Sylviana Pratikha e Novesar Jamarun. "SYNTHESIS AND CHARACTERIZATION OF MODIFIED MESOPOROUS SILICA-IMOBILIZED Cu(II)-ACETONITRILE COMPLEX AND ITS APPLICATION IN TRANSESTERIFICATION OF FRYING OIL". Jurnal Riset Kimia 7, n. 2 (12 febbraio 2015): 174. http://dx.doi.org/10.25077/jrk.v7i2.184.

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ABSTRACTMesoporous silica has attracted rapidly growing attention in catalysis. In this work, mesoporoussilica was synthesized by using CTAB surfactant and then modified by AlCl3. Such materialwas used as support for Cu(II)--acetonitile complex and applied in transesterification of fryingoil. The XRD pattern of the obtained silica confirms the availability of chracteristic peak onsilica surface while its TEM exhibits the uniformity of nanochannel of the mesoporous silica.The particle size of silica support has become smaller after grafting process showed by SEMimages. FT-IR spectra of the materials indicated that the Cu(II) grafted on the mesoporoussilica was in the form of its acetonitrile complex. Supprisingly, the Cu loading the graftedcatalyst was found to be very high. That was 21%, when the catalyst applied ontransesterification of the examined frying oil the amount of total methyl ester yielded were of65%.Keywords: mesoporous silica, AlCl3, Cu(II)-acetonitrile complex, transesterification

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Zhou, Ping, e Bin Su. "Enhanced electrochemiluminescence at silica nanochannel membrane studied by scanning electrochemical microscopy". Journal of Electroanalytical Chemistry 904 (gennaio 2022): 115943. http://dx.doi.org/10.1016/j.jelechem.2021.115943.

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Zhang, Bo, Marissa Wood e Hyunae Lee. "A Silica Nanochannel and Its Applications in Sensing and Molecular Transport". Analytical Chemistry 82, n. 8 (15 aprile 2010): 3404. http://dx.doi.org/10.1021/ac100675w.

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Zhang, Bo, Marissa Wood e Hyunae Lee. "A Silica Nanochannel and Its Applications in Sensing and Molecular Transport". Analytical Chemistry 81, n. 13 (luglio 2009): 5541–48. http://dx.doi.org/10.1021/ac9009148.

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Yan, Fei, Lina Yao, Kenxin Chen, Qian Yang e Bin Su. "An ultrathin and highly porous silica nanochannel membrane: toward highly efficient salinity energy conversion". Journal of Materials Chemistry A 7, n. 5 (2019): 2385–91. http://dx.doi.org/10.1039/c8ta10848j.

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Ma, Ning, Xuan Luo, Weidong Wu e Jiyang Liu. "Fabrication of a Disposable Electrochemical Immunosensor Based on Nanochannel Array Modified Electrodes and Gated Electrochemical Signals for Sensitive Determination of C-Reactive Protein". Nanomaterials 12, n. 22 (11 novembre 2022): 3981. http://dx.doi.org/10.3390/nano12223981.

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Abstract (sommario):

Sensitive determination of C-reactive protein (CRP) is of great significance because it is an early indicator of inflammation in cardiovascular disease and acute myocardial infarction. A disposable electrode with an integrated three-electrode system (working, reference, and counter electrodes) has great potential in the detection of biomarkers. In this work, an electrochemical immunosensing platform was fabricated on disposable and integrated screen-printed carbon electrode (SPCE) by introducing nanochannel arrays and gated electrochemical signals, which can achieve the sensitive detection of CRP in serum. To introduce active reactive groups for the fabrication of immuno-recognitive interface, vertically-ordered mesoporous silica-nanochannel film (VMSF) with rich amino groups (NH2-VMSF) was rapidly grown by electrochemical assisted self-assembly (EASA). The electrochemically reduced graphene oxide (ErGO) synthesized in situ during the growth of NH2-VMSF was used as a conductive adhesive glue to achieve stable bonding of the nanochannel array (NH2-VMSF/ErGO/SPCE). After the amino group on the outer surface of NH2-VMSF reacted with bifunctional glutaraldehyde (GA/NH2-VMSF/ErGO/SPCE), the converted aldehyde surface was applied for covalent immobilization of the recognitive antibody (Ab) followed with the blocking of the non-specific sites. The fabricated immunosensor, Ab/GA/NH2-VMSF/ErGO/SPCE, enables sensitive detection of CRP in the range from 10 pg/mL to 100 ng/mL with low limit of detection (LOD, 8 pg/mL, S/N = 3). The immunosensor possessed high selectivity and can realize reliable determination of CRP in human serum.

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Zhou, Ping, Lina Yao, Kexin Chen e Bin Su. "Silica Nanochannel Membranes for Electrochemical Analysis and Molecular Sieving: A Comprehensive Review". Critical Reviews in Analytical Chemistry 50, n. 5 (27 luglio 2019): 424–44. http://dx.doi.org/10.1080/10408347.2019.1642735.

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Lin, Xingyu, Bowen Zhang, Qian Yang, Fei Yan, Xin Hua e Bin Su. "Polydimethysiloxane Modified Silica Nanochannel Membrane for Hydrophobicity-Based Molecular Filtration and Detection". Analytical Chemistry 88, n. 15 (22 luglio 2016): 7821–27. http://dx.doi.org/10.1021/acs.analchem.6b01866.

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Wang, Yafeng, Xingyu Lin e Bin Su. "Redox cycling with ITO electrodes separated by an ultrathin silica nanochannel membrane". Electrochemistry Communications 72 (novembre 2016): 1–4. http://dx.doi.org/10.1016/j.elecom.2016.08.016.

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Zhao, Meijiao, Yanhuan Liu e Bin Su. "Anomalous Proton Transport across Silica Nanochannel Membranes Investigated by Ion Conductance Measurements". Analytical Chemistry 91, n. 21 (ottobre 2019): 13433–38. http://dx.doi.org/10.1021/acs.analchem.9b01914.

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Duan, Lixia, Chaoyan Zhang, Fengna Xi, Danke Su e Wenhao Zhang. "Direct and Sensitive Electrochemical Determination of Total Antioxidant Capacity in Foods Using Nanochannel-Based Enrichment of Redox Probes". Molecules 29, n. 11 (21 maggio 2024): 2423. http://dx.doi.org/10.3390/molecules29112423.

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Abstract (sommario):

Simple and sensitive determination of total antioxidant capacity (TAC) in food samples is highly desirable. In this work, an electrochemical platform was established based on a silica nanochannel film (SNF)-modified electrode, facilitating fast and highly sensitive analysis of TAC in colored food samples. SNF was grown on low-cost and readily available tin indium oxide (ITO) electrode. Fe3+-phenanthroline complex-Fe(III)(phen)3 was applied as the probe, and underwent chemical reduction to form Fe2+-phenanthroline complex-Fe(II)(phen)3 in the presence of antioxidants. Utilizing an oxidative voltage of +1 V, chronoamperometry was employed to measure the current generated by the electrochemical oxidation of Fe(II)(phen)3, allowing for the assessment of antioxidants. As the negatively charged SNF displayed remarkable enrichment towards positively charged Fe(II)(phen)3, the sensitivity of detection can be significantly improved. When Trolox was employed as the standard antioxidant, the electrochemical sensor demonstrated a linear detection range from 0.01 μM to 1 μM and from 1 μM to 1000 μM, with a limit of detection (LOD) of 3.9 nM. The detection performance is better that that of the conventional colorimetric method with a linear de range from 1 μM to 40 μM. Owing to the anti-interfering ability of nanochannels, direct determination of TAC in colored samples including coffee, tea, and edible oils was realized.

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Yu, Ruliang, Yujiao Zhao e Jiyang Liu. "Solid Electrochemiluminescence Sensor by Immobilization of Emitter Ruthenium(II)tris(bipyridine) in Bipolar Silica Nanochannel Film for Sensitive Detection of Oxalate in Serum and Urine". Nanomaterials 14, n. 5 (20 febbraio 2024): 390. http://dx.doi.org/10.3390/nano14050390.

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Convenient and highly sensitive detection of oxalate ions in body fluids is of crucial significance for disease prevention, diagnosis, and monitoring of treatment effectiveness. Establishing a simple solid-state electrochemiluminescence (ECL) sensing system for highly sensitive detection of oxalate ions is highly desirable. In this work, a solid ECL sensor was fabricated by immobilizing the commonly used emitter ruthenium(II)tris(bipyridine) (Ru(bpy)32+) on a double-layered bipolar silica nanochannel array film (bp-SNA)-modified electrode, enabling sensitive detection of oxalate ions in serum or urine samples. Cost-effective and readily available indium tin oxide (ITO) was used as the supporting electrode. Convenient fabrication of multiple negatively charged SNA (n-SNA)-modified ITO electrodes was achieved through the one-step Stöber solution growth method. Subsequently, a positive outer layer film (p-SNA) was rapidly prepared using an electrochemical-assisted self-assembly method. The double-layered bipolar silica nanochannel array film achieved stable immobilization of Ru(bpy)32+ on the electrode surface, facilitated by the electrostatic adsorption of Ru(bpy)32+ by n-SNA and the electrostatic repulsion by p-SNA. Utilizing oxalate ions as a co-reactant for Ru(bpy)32+, combined with the electrostatic enrichment of oxalate ions by p-SNA, the constructed sensor enabled highly sensitive detection of oxalate ions ranging from 1 nM to 25 μM and from 25 μM to 1 mM, with a detection limit (LOD) of 0.8 nM. The fabricated ECL sensor exhibited high selectivity and good stability, making it suitable for ECL detection of oxalate ions in serum and urine samples.

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Deng, Xiaochun, Xueting Lin, Huaxu Zhou, Jiyang Liu e Hongliang Tang. "Equipment of Vertically-Ordered Mesoporous Silica Film on Electrochemically Pretreated Three-Dimensional Graphene Electrodes for Sensitive Detection of Methidazine in Urine". Nanomaterials 13, n. 2 (5 gennaio 2023): 239. http://dx.doi.org/10.3390/nano13020239.

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Direct, rapid, and sensitive detection of drugs in complex biological samples is essential for drug abuse control and health risk assessment. In this work, an electrochemical sensor was fabricated based on equipment of vertically-ordered mesoporous silica film (VMSF) on an electrochemically pre-treated three-dimensional graphene electrode (p-3DG), which can achieve direct and sensitive determination of methylthiopyridazine (TR) in urine. Three-dimensional graphene (3DG) with a continuous and interpenetrating graphene network was used as the supporting electrode and simple electrochemical polarization was employed to pre-treat 3DG to improve surface hydrophilicity and electrocatalytic performance. VMSF was easily grown using an electrochemical assisted self-assembly method within 10 s and was stably bound to the p-3DG surface. The nanochannel array on the as-prepared VMSF/p-3DG sensor enriched positively charged TR, leading to significantly improved electrochemical signal. Combined with the high electric activity of p-3DG and the enrichment of nanochannels, VMSF/p-3DG realized sensitive determination of TR ranging from 50 nM to 10 μM with a low detection limit (DL, 30 nM). Owing to the anti-fouling and anti-interference performance of VMSF, the common electroactive molecules including ascorbic acid (AA) and uric acid (UA) did not interfere with the detection. In addition, the detection of TR in buffer and urine exhibited similar sensitivity. Accurate detection of TR in urine was realized.

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Ma, Kai, Luoxing Yang, Jun Liu e Jiyang Liu. "Electrochemical Sensor Nanoarchitectonics for Sensitive Detection of Uric Acid in Human Whole Blood Based on Screen-Printed Carbon Electrode Equipped with Vertically-Ordered Mesoporous Silica-Nanochannel Film". Nanomaterials 12, n. 7 (31 marzo 2022): 1157. http://dx.doi.org/10.3390/nano12071157.

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Screen-printed carbon electrodes (SPCEs) bear great potential in the detection of biomarker in clinical samples with low sample consumption. However, modification of electrode surfaces to improve the anti-interference ability and sensitivity is highly desirable for direct electroanalysis of whole blood samples. Here, a reliable and miniaturized electrochemical sensor is demonstrated based on SPCE equipped with vertically-ordered mesoporous silica-nanochannel film (VMSF). To achieve stable binding of VMSF and improve the electrocatalytic performance, electrochemically reduced graphene oxide (ErGO) is applied as a conductive adhesion layer, that is in situ reduced from GO nanosheets during fast growth (less than 10 s) of amino groups modified VMSF (NH2-VMSF) using electrochemically assisted self-assembly (EASA). In comparison with bare SPCE, NH2-VMSF/ErGO/SPCE exhibits decreased oxidation potential of uric acid (UA) by 147 mV owing to significant electrocatalytic ability of ErGO. The dual signal amplification based on electrocatalysis of ErGO and enrichment of nanochannels leads to enhanced peak current by 3.9 times. Thus, the developed NH2-VMSF/ErGO/SPCE sensor enables sensitive detection of UA in the range from 0.5 μM to 180 μM with a low limit of detection (LOD, 129 nM, S/N = 3). Owing to good anti-fouling ability and high selectivity of the sensor, direct and rapid detection of UA in human whole blood is realized with very low sample consumption (50 μL).

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Yang, Qian, Xingyu Lin e Bin Su. "Molecular Filtration by Ultrathin and Highly Porous Silica Nanochannel Membranes: Permeability and Selectivity". Analytical Chemistry 88, n. 20 (7 ottobre 2016): 10252–58. http://dx.doi.org/10.1021/acs.analchem.6b02968.

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36

Xiao, Yi, Suhua Chen, Guocan Zhang, Zhimao Li, Han Xiao, Chuanpin Chen, Chunlian He, Ran Zhang e Xiaoping Yang. "Simple and rapid nicotine analysis using a disposable silica nanochannel-assisted electrochemiluminescence sensor". Analyst 145, n. 14 (2020): 4806–14. http://dx.doi.org/10.1039/d0an00588f.

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Zhou, Xile, Qianqian Han, Jinming Zhou, Chaoxu Liu e Jiyang Liu. "Reagentless Electrochemical Detection of Tumor Biomarker Based on Stable Confinement of Electrochemical Probe in Bipolar Silica Nanochannel Film". Nanomaterials 13, n. 10 (15 maggio 2023): 1645. http://dx.doi.org/10.3390/nano13101645.

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The development of simple and probe-integrated aptamer sensors for the electrochemical detection of tumor biomarkers is of great significance for the diagnosis of tumors and evaluation of prognosis. In this work, a probe-integrated aptamer sensor is demonstrated based on the stable confinement of an electrochemical probe in a bipolar nanochannel film, which can realize the reagentless electrochemical detection of the tumor biomarker carcinoembryonic antigen (CEA). To realize the stable immobilization of a large amount of the cationic electrochemical probe methylene blue (MB), a two-layer silica nanochannel array (SNF) with asymmetric charge was grown on the supporting electrode from bipolar SNF (bp-SNF). The inner SNF is negatively charged (n-SNF), and the outer-layer SNF is positively charged (p-SNF). The dual electrostatic interaction including the electrostatic adsorption from n-SNF and the electrostatic repulsion from p-SNF achieve the stable confinement of MB in bp-SNF. The recognitive interface is fabricated by the covalent immobilization of the CEA aptamer on the outer surface of bp-SNF, followed by the blocking of non-specific binding sites. Owing to the stable and abundant immobilized probes and highly specific aptamer interface, the developed aptamer sensor enables the sensitive detection of CEA in the range of 1 pg/mL to 1 μg/mL with a low limit of detection (LOD, 0.22 pg/mL, S/N = 3). Owing to the high selectivity and stability of the developed biosensor, reagentless electrochemical detection of CEA in serum was realized.

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Wang, Kai, Luoxing Yang, Huili Huang, Ning Lv, Jiyang Liu e Youshi Liu. "Nanochannel Array on Electrochemically Polarized Screen Printed Carbon Electrode for Rapid and Sensitive Electrochemical Determination of Clozapine in Human Whole Blood". Molecules 27, n. 9 (24 aprile 2022): 2739. http://dx.doi.org/10.3390/molecules27092739.

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Rapid and highly sensitive determination of clozapine (CLZ), a psychotropic drug for the treatment of refractory schizophrenia, in patients is of great significance to reduce the risk of disease recurrence. However, direct electroanalysis of CLZ in human whole blood remains a great challenge owing to the remarkable fouling that occurs in a complex matrix. In this work, a miniaturized, integrated, disposable electrochemical sensing platform based on the integration of nanochannel arrays on the surface of screen-printed carbon electrodes (SPCE) is demonstrated. The device achieves high determination sensitivity while also offering the electrode anti-fouling and anti-interference capabilities. To enhance the electrochemical performance of SPCE, simple electrochemical polarization including anodic oxidation and cathodic reduction is applied to pretreat SPCE. The electrochemically polarized SPCE (p-SPCE) exhibits an enhanced electrochemical peak signal toward CLZ compared with bare SPCE. An electrochemically assisted self-assembly method (EASA) is utilized to conveniently electrodeposit a vertically ordered mesoporous silica nanomembrane film (VMSF) on the p-SPCE, which could further enrich CLZ through electrostatic interactions. Owing to the dual signal amplification based on the p-SPCE and VMSF nanochannels, the developed VMSF/SPCE sensor enables determination of CLZ in the range from 50 nM to 20 μM with a low limit of detection (LOD) of 28 nM (S/N = 3). Combined with the excellent anti-fouling and anti-interference abilities of VMSF, direct and sensitive determination of CLZ in human blood is also achieved.

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Wang, Kai, Luoxing Yang, Huili Huang, Ning Lv, Jiyang Liu e Youshi Liu. "Nanochannel Array on Electrochemically Polarized Screen Printed Carbon Electrode for Rapid and Sensitive Electrochemical Determination of Clozapine in Human Whole Blood". Molecules 27, n. 9 (24 aprile 2022): 2739. http://dx.doi.org/10.3390/molecules27092739.

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Abstract (sommario):

Rapid and highly sensitive determination of clozapine (CLZ), a psychotropic drug for the treatment of refractory schizophrenia, in patients is of great significance to reduce the risk of disease recurrence. However, direct electroanalysis of CLZ in human whole blood remains a great challenge owing to the remarkable fouling that occurs in a complex matrix. In this work, a miniaturized, integrated, disposable electrochemical sensing platform based on the integration of nanochannel arrays on the surface of screen-printed carbon electrodes (SPCE) is demonstrated. The device achieves high determination sensitivity while also offering the electrode anti-fouling and anti-interference capabilities. To enhance the electrochemical performance of SPCE, simple electrochemical polarization including anodic oxidation and cathodic reduction is applied to pretreat SPCE. The electrochemically polarized SPCE (p-SPCE) exhibits an enhanced electrochemical peak signal toward CLZ compared with bare SPCE. An electrochemically assisted self-assembly method (EASA) is utilized to conveniently electrodeposit a vertically ordered mesoporous silica nanomembrane film (VMSF) on the p-SPCE, which could further enrich CLZ through electrostatic interactions. Owing to the dual signal amplification based on the p-SPCE and VMSF nanochannels, the developed VMSF/SPCE sensor enables determination of CLZ in the range from 50 nM to 20 μM with a low limit of detection (LOD) of 28 nM (S/N = 3). Combined with the excellent anti-fouling and anti-interference abilities of VMSF, direct and sensitive determination of CLZ in human blood is also achieved.

40

Huang, Zhongnan, Xuan Luo, Fei Yan e Bo Zhou. "Homogeneous Electrochemical Aptasensor for Sensitive Detection of Zearalenone Using Nanocomposite Probe and Silica Nanochannel Film". Molecules 28, n. 21 (24 ottobre 2023): 7241. http://dx.doi.org/10.3390/molecules28217241.

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Developing rapid and efficient analytical methods is of great importance for food safety Herein, we present a novel homogeneous electrochemical aptasensor for ultrasensitive quantitative determination of zearalenone (ZEN) based on a nanocomposite probe and silica nanochannel film. X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy and UV–Vis characterization techniques confirm that graphene oxide (GO) bears an aromatic conjugated structure, along with hydroxyl and carboxyl groups, facilitating the subsequent adsorption of cationic redox hexa-ammine-ruthenium (III) (Ru(NH3)63+) and anionic ZEN aptamer, to form a Ru(NH3)63+–ZEN aptamer–GO nanocomposite probe in a homogeneous solution. Vertically-ordered mesoporous silica films (VMSF) bearing silanol groups can be simply grown on the solid indium tin oxide (ITO) electrode surface and enable the selective preconcentration of Ru(NH3)63+, eventually leading to signal amplification. Since the detachment of Ru(NH3)63+ from the GO surface by the recognized ZEN aptamer in the presence of ZEN, more free Ru(NH3)63+ is released in solution and produces enhanced redox signals at the VMSF modified ITO electrode, allowing quantitative detection of ZEN. On the basis of the above sensing strategy, the proposed homogeneity, due to the assistance of graphene, as well as of the signal amplification and anti-fouling effects of VMSF, accurate analysis of ZEN can be realized in maize and Chinese chestnut samples.

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Zhang, Huihua, Chaoyan Zhang, Hui Qu e Fengna Xi. "Immunosensor with Enhanced Electrochemiluminescence Signal Using Platinum Nanoparticles Confined within Nanochannels for Highly Sensitive Detection of Carcinoembryonic Antigen". Molecules 28, n. 18 (11 settembre 2023): 6559. http://dx.doi.org/10.3390/molecules28186559.

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Rapid, highly sensitive, and accurate detection of tumor biomarkers in serum is of great significance in cancer screening, early diagnosis, and postoperative monitoring. In this study, an electrochemiluminescence (ECL) immunosensing platform was constructed by enhancing the ECL signal through in situ growth of platinum nanoparticles (PtNPs) in a nanochannel array, which can achieve highly sensitive detection of the tumor marker carcinoembryonic antigen (CEA). An inexpensive and readily available indium tin oxide (ITO) glass electrode was used as the supporting electrode, and a layer of amino-functionalized vertically ordered mesoporous silica film (NH2-VMSF) was grown on its surface using an electrochemically assisted self-assembly method (EASA). The amino groups within the nanochannels served as anchoring sites for the one-step electrodeposition of PtNPs, taking advantage of the confinement effect of the ultrasmall nanochannels. After the amino groups on the outer surface of NH2-VMSF were derivatized with aldehyde groups, specific recognition antibodies were covalently immobilized followed by blocking nonspecific binding sites to create an immunorecognition interface. The PtNPs, acting as nanocatalysts, catalyzed the generation of reactive oxygen species (ROS) with hydrogen peroxide (H2O2), significantly enhancing the ECL signal of the luminol. The ECL signal exhibited high stability during continuous electrochemical scanning. When the CEA specifically bound to the immunorecognition interface, the resulting immune complexes restricted the diffusion of the ECL emitters and co-reactants towards the electrode, leading to a reduction in the ECL signal. Based on this immune recognition-induced signal-gating effect, the immunosensor enabled ECL detection of CEA with a linear range of 0.1 pg mL−1 to 1000 ng mL−1 with a low limit of detection (LOD, 0.03 pg mL−1). The constructed immunosensor demonstrated excellent selectivity and can achieve CEA detection in serum.

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Liu, Xiangyang, Xiaotong Zong, Sa Xue, Hui Liu e Maogang He. "Molecular structure and transport of ionic liquid confined in asymmetric graphene-coated silica nanochannel". Journal of Molecular Liquids 345 (gennaio 2022): 117869. http://dx.doi.org/10.1016/j.molliq.2021.117869.

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Okazaki, Masaharu, e Kazumi Toriyama. "Inhomogeneous Distribution and Collective Diffusion of Solution Molecules in the Nanochannel of Mesoporous Silica". Journal of Physical Chemistry B 107, n. 31 (agosto 2003): 7654–58. http://dx.doi.org/10.1021/jp0345351.

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Yan, Youguo, Chuanyong Li, Zihan Dong, Timing Fang, Baojiang Sun e Jun Zhang. "Enhanced oil recovery mechanism of CO 2 water-alternating-gas injection in silica nanochannel". Fuel 190 (febbraio 2017): 253–59. http://dx.doi.org/10.1016/j.fuel.2016.11.019.

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45

Wang, Yafeng, Qian Yang, Meijiao Zhao, Jianmin Wu e Bin Su. "Silica-Nanochannel-Based Interferometric Sensor for Selective Detection of Polar and Aromatic Volatile Organic Compounds". Analytical Chemistry 90, n. 18 (13 agosto 2018): 10780–85. http://dx.doi.org/10.1021/acs.analchem.8b01681.

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46

Zhang, Haidong, e Xiaohong Li. "Novel Mesoporous Silica Materials with Hierarchically Ordered Nanochannel: Synthesis with the Assistance of Straight-Chain Alkanes and Application". Journal of Chemistry 2016 (2016): 1–16. http://dx.doi.org/10.1155/2016/5146573.

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The straight-chain alkane-assisted synthesis of hierarchical mesoporous silica materials (MSM) results in variable mesostructures and morphologies due to remarkably different self-assembly routes of template agent from those without the assistance of straight-chain alkanes. The textural properties, particularly pore size, channel structure, morphology, and hierarchical structure of those MSM make them demonstrate peculiar effects in the immobilization of homogeneous catalysts.

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Rao, Qi, Yidong Xia, Jiaoyan Li, Milind Deo e Zhen Li. "Flow reduction of hydrocarbon liquid in silica nanochannel: Insight from many-body dissipative particle dynamics simulations". Journal of Molecular Liquids 344 (dicembre 2021): 117673. http://dx.doi.org/10.1016/j.molliq.2021.117673.

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48

Yao, Lina, Kexin Chen e Bin Su. "Unraveling Mass and Electron Transfer Kinetics at Silica Nanochannel Membrane Modified Electrodes by Scanning Electrochemical Microscopy". Analytical Chemistry 91, n. 24 (21 novembre 2019): 15436–43. http://dx.doi.org/10.1021/acs.analchem.9b03044.

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Zhang, Yue, Shiyue Zhang, Jiyang Liu e Dongyuan Qin. "Label-Free Homogeneous Electrochemical Aptasensor Based on Size Exclusion/Charge-Selective Permeability of Nanochannel Arrays and 2D Nanorecognitive Probe for Sensitive Detection of Alpha-Fetoprotein". Molecules 28, n. 19 (5 ottobre 2023): 6935. http://dx.doi.org/10.3390/molecules28196935.

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Abstract (sommario):

The labeling-free and immobilization-free homogeneous aptamer sensor offers advantages including simple operation, low cost, and high sensitivity, demonstrating great potential in rapid detection of tumor biomarkers in biological samples. In this work, a labeling-free and immobilization-free homogeneous aptamer sensor was conveniently fabricated by combining size exclusion and charge-selective penetration of a nanochannel-modified electrode and two-dimensional (2D) nanorecognition probe which can realize selective and highly sensitive detection of alpha-fetoprotein (AFP) in serum. Vertically ordered mesoporous silica film (VMSF) with ultra-small, uniform, and vertically aligned nanochannels was easily grown on the simple, low-cost, and disposable indium tin oxide (ITO) electrode. Through π-π interaction and electrostatic force, the AFP aptamer (Apt) and electrochemical probe, tris(bipyridine)ruthenium(II) (Ru(bpy)32+), were coloaded onto graphene oxide (GO) through simple incubation, forming a 2D nanoscale recognition probe (Ru(bpy)32+/Apt@GO). Owing to the size exclusion effect of VMSF towards the 2D nanoscale probe, the electrochemical signal of Ru(bpy)32+/Apt@GO could not be detected. In the presence of AFP, the specific binding of AFP to the aptamer causes the dissociation of the aptamer and Ru(bpy)32+ from GO, resulting in their presence in the solution. The efficient electrostatic enrichment towards Ru(bpy)32+ by negatively charged VMSF allows for high electrochemical signals of free Ru(bpy)32+ in the solution. Linear determination of AFP ranged from 1 pg/mL to 1000 ng/mL and could be obtained with a low limit of detection (LOD, 0.8 pg/mL). The high specificity of the adapter endowed the constructed sensor with high selectivity. The fabricated probe can be applied in direct determination of AFP in serum.

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Zhang, Ming, Y. Bando e K. Wada. "Silicon dioxide nanotubes prepared by anodic alumina as templates". Journal of Materials Research 15, n. 2 (febbraio 2000): 387–92. http://dx.doi.org/10.1557/jmr.2000.0061.

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Abstract (sommario):

Aligned slicon dioxide nanotubes with diameters of 30–40 nm synthesized by the sol-gel template method are presented. This process involves the growth of nanotubes from ordered nanochannel-array pores in anodic alumina. For a silica sol aged at room temperature and dipped for 1 min, nanowires were formed in a shorter period of aging time (2 days); nanotubes connecting with solid nanofibers were obtained in a longer aging time (30 days). The formation of nanotubes depends strongly on the temperature of the sol. For a short dipping time (<1 min), bamboolike nanofibers were prepared when the sol was at high temperature (50 °C); however, perfect nanotubes with the sharp wall were synthetized for the lower sol temperature (5 °C). The lower sol temperature is, the smoother the inside wall of nanotubes is. It is proved that viscosity plays an important role on the morphology of nanotubes.

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