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Tesi sul tema "Sequencer"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 9 febbraio 2022

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1

Persson, Daniel. "Sequi : Tredimensionell sequencer." Thesis, Konstfack, Grafisk Design & Illustration, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:konstfack:diva-4707.

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Music production software has a strong tradition of two-dimensional graphical user interface (GUI), in which the time line is represented as a flat composition either horizontally (from left to right) or vertically (from top to bottom). In my degree work titled Sequi, I approach music composition from a different angle. Instead of a two-dimensional time line with only two possibly ways of progression (forward or backward) I constructed a three-dimensional GUI with the maximum of four different ways of progression from any given point in a composition. The height axis is used to describe time-i

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2

Ait-Ghezala, Ahmed 1976. "Software systems for a DNA sequencer." Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/8931.

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Thesis (M.Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2000.<br>Includes bibliographical references (leaf 49).<br>The initiative to complete the sequencing of the human genome is bringing the need for high-throughput sequencing capabilities to the forefront. We at the BioMEMS engineering group at the Whitehead Institute are designing and building a new sequencing machine that uses a 384 glass "chip" to dramatically increase sequencing rates. This thesis describes the design and implementation of two of the machine's software compo

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3

Crabtree, H. John. "Development of a high throughput, multicapillary DNA sequencer." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq21562.pdf.

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4

Pháº¡m, Paul Tân Tháº¿. "A general-purpose pulse sequencer for quantum computing." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/32106.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2005.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Includes bibliographical references (p. 165-170).<br>Quantum mechanics presents a more general and potentially more powerful model of computation than classical systems. Quantum bits have many physically different representations which nonetheless share a common need for modulating pulses of electromagnetic waves. This thesis pr

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5

Bay, Sue J. "The construction and evaluation of a multiple capillary DNA sequencer." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ34733.pdf.

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6

Zhu, Zhineng. "Low Noise Offset Operational Amplifier for Nanopore-based Gene Sequencer." Fogler Library, University of Maine, 2007. http://www.library.umaine.edu/theses/pdf/ZhuZ2007.pdf.

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7

Bowler, I. "Digital techniques in the storage and processing of audio waveforms for music synthesis." Thesis, Bucks New University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373583.

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8

Brandt, Jason J. "Fault-tolerant sequencer using FPGA-based logic designs for space applications." Thesis, Monterey, California: Naval Postgraduate School, 2013. http://hdl.handle.net/10945/38884.

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Approved for public release; distribution is unlimited.<br>The design of a device that controls the sequence and timing of deployment of CubeSats on the Naval Postgraduate Schools CubeSat Launcher (NPSCuL) is detailed in this thesis. This design is intended to be implemented on a field-programmable gate array (FPGA) installed into the NPSCuL. This configuration allows flexibility in reprogramming the launch sequence and adding additional functionality in future designs. Operating an FPGA on orbit presents unique challenges due to the radiation environment. Radiation from space cannot be shield

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9

Tumati, Raghu. "Solid-State Nanopore Characterization and Low noise Transimpedance Amplifier for Nanopore-Based Gene Sequencer." Fogler Library, University of Maine, 2008. http://www.library.umaine.edu/theses/pdf/TumatiR2008.pdf.

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10

Goff, Jordan K. "Adaptation of a fault–tolerant FPGA–based launch sequencer as a CubeSat payload processor." Thesis, Monterey, California: Naval Postgraduate School, 2014. http://hdl.handle.net/10945/42634.

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Approved for public release; distribution is unlimited<br>The purpose of this thesis is to design and test a fault–tolerant reduced instruction set computer processor running a subset of the multiprocessor without interlocked pipelined stages instruction set. This processor is implemented on a field programmable gate array (FPGA) and will be used as the foundation for a payload processor on a cube satellite developed at the Naval Postgraduate School. This thesis begins by considering the radiation effects present in the space environment and the various fault– tolerant designs used to guard ag

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11

Parobek, Lucas S. "RESEARCH, DEVELOPMENT AND TESTING OF A FAULT-TOLERANT FPGA-BASED SEQUENCER FOR CUBESAT LAUNCHING APPLICATIONS." Monterey, California. Naval Postgraduate School, 2013. http://hdl.handle.net/10945/32882.

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This thesis concerns various means of implementing fault tolerance in logic for use in a general payload processor design. The first specific application of this research is a sequencer developed for deploying CubeSats. The sequencer shall be capable of the timing and accurate deployment of multiple CubeSats from a host spacecraft and shall have the capability for quick reconfiguration prior to launch. This research considers a variety of hardware for suitability toward sequencer construction; field programmable gate arrays (FPGAs) are chosen as the primary device. The design further evolves t

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12

Borgen, Gary. "MICROCONTROLLER BASED PCM ENCODERS FOR TELEMETRY INSTRUMENTATION." International Foundation for Telemetering, 2005. http://hdl.handle.net/10150/604920.

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ITC/USA 2005 Conference Proceedings / The Forty-First Annual International Telemetering Conference and Technical Exhibition / October 24-27, 2005 / Riviera Hotel & Convention Center, Las Vegas, Nevada<br>Pulse Code Modulation (PCM) Encoders used in Telemetry Instrumentation systems have traditionally been implemented using sequencer or state-machine based micro-architectures with distributed control and signal acquisition components. This architecture requires the use of many discrete electronic components and custom micro-code programming or state machine development for the control of the sy

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13

Carrier, Grégory. "Bases moléculaires de la variation clonale chez la vigne (Vitis vinifera L.) : approche pangénomique." Thesis, Montpellier, SupAgro, 2011. http://www.theses.fr/2011NSAM0039/document.

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L'exploitation de la variation clonale est une des voies d'amélioration utilisée chez un grand nombre de plantes d'intérêts agronomiques telles que la pomme de terre, le café et la vigne. En effet, après plusieurs cycles de reproduction végétative, des caractéristiques agronomiques stables apparaissent donnant naissance à une diversité phénotypique remarquable, appelée « diversité clonale ». Chez la vigne, cette diversité clonale est d'une importance majeure pour les viticulteurs puisqu'elle permet une amélioration variétale sans changer d'identité de cépage en conformité avec la réglementatio

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14

Cai, Zheng. "Repetitive sequence analysis for soybean genome sequences." Diss., Columbia, Mo. : University of Missouri-Columbia, 2005. http://hdl.handle.net/10355/4249.

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Thesis (M.S.)--University of Missouri-Columbia, 2005.<br>"May 2005" The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Includes bibliographical references.

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15

Göran, Sandström. "Procedural Sequencing : a New Form of Procedural Music Creation." Thesis, Högskolan Kristianstad, Sektionen för hälsa och samhälle, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-10699.

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With increased availability of smartphones, game consoles and computers with capabilities of synthesizing procedural music in real time comes the challenge of realizing new tools for generative music composition for games, inter-media art and musical live performance.This work defines a new method of creating music, “procedural sequencing”, and it presents a musical software that attempts to solve some of the design challenges of bridging interactive elements and more traditional tools for music composition. The software combines aspects of live coding with tracker sequencing.

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16

Ireland, Ian D. "High sensitivity protein sequencing using fluorescein isothiocyanate for derivatization on a miniaturized sequencer using capillary electrophoresis with laser induced fluorescence detection for product identification." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0009/NQ59975.pdf.

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17

VITTE, PATRICK. "Plus longue sous-sequence commune et analyse de sequences biologiques." Aix-Marseille 2, 1996. http://www.theses.fr/1996AIX22073.

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Cette these est consacree a l'etude des plus longues sous-sequences communes (lcs) a un ensemble de chaines de caracteres et a leur usage dans l'analyse des sequences biologiques. En deux mots, une sous-sequence commune a plusieurs chaines est une suite de caracteres, pas necessairement consecutifs, que l'on trouve dans le meme ordre dans chaque chaine. Les lcs nous interesse selon deux points de vue: algorithmique: peut-on determiner, approximer et encadrer leur longueur ? comment construire une lcs ? peut-on les enumerer ? ces questions sont classiques en optimisation combinatoire et nous av

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18

Arner, Erik. "Solving repeat problems in shotgun sequencing /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-996-3/.

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19

Pray, Keith A. "Apriori Sets And Sequences: Mining Association Rules from Time Sequence Attributes." Link to electronic thesis, 2004. http://www.wpi.edu/Pubs/ETD/Available/etd-0506104-150831/.

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Thesis (M.S.) -- Worcester Polytechnic Institute.<br>Keywords: mining complex data; temporal association rules; computer system performance; stock market analysis; sleep disorder data. Includes bibliographical references (p. 79-85).

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20

Faulkner, Sean (Sean Anthony) Carleton University Dissertation Engineering Electrical. "Composite sequences for rapid acquisition of direct-sequence spread spectrum signals." Ottawa, 1992.

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21

Dvořák, Pavel. "Sekvencer pro obsluhu krátkovlnné radiostanice." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2012. http://www.nusl.cz/ntk/nusl-219884.

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In this paper we will deal involving short-wave radio station and its control by the sequencer. Mostly it will be a time delay of the PA and the antenna switching relay in the transmitter (TX) to receiver (RX) side. Time delays will be controlled programmatically using ATmega 16 microprocessor, which will form part of the main control sequencer. The delay will set the total time of keying in messages, when we take into account the loss due to delayed first symbol. Keying will be done from several sources, among the main sources will be ordered from keying the radio, telegraph keys, and PC. The

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22

Parsons, Jeremy David. "Computer analysis of molecular sequences." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282922.

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23

Lui, Man-Cheung Max. "Generation and evaluation of mechanical assembly sequences using the liaison-sequence method." Thesis, Massachusetts Institute of Technology, 1988. http://hdl.handle.net/1721.1/14544.

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24

Seth, Pawan. "STUDY OF THE RELATIONSHIP BETWEEN Mus musculus PROTEIN SEQUENCES AND THEIR BIOLOGICAL FUNCTIONS." University of Akron / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=akron1176736255.

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25

Lomas, Martin John. "A bioinformatics analysis of sequences and sequence libraries from the moss Physcomitrella patens." Thesis, University of Leeds, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396944.

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26

Farrington, Paul. "The behaviour of sequence transformations as applied to slowly converging sequences and series." Thesis, Keele University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327636.

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27

陳子健 and Chi-kin John Baptist Chan. "A study of binary sequences for direct-sequence spread-spectrum multiple-access communication systems." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1996. http://hub.hku.hk/bib/B31212761.

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28

Chan, Chi-kin John Baptist. "A study of binary sequences for direct-sequence spread-spectrum multiple-access communication systems /." Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B16043005.

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29

Ritter, Geoffrey William. "Lithofaces and Sequence Architecture of the Upper Paradox Formation (Middle Pennsylvanian)in the Subsurface Northern Blanding Subbasin, Paradox Basin, Utah." BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/7319.

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THE PARADOX Basin is a northwest-southeast trending intracratonic basin that formedin southwestern Colorado, southeastern Utah and adjacent parts of Arizona and New Mexicoduring the late Paleozoic Era. During rise of the adjacent Uncompahgre Uplift (Ancestral RockyMountains) the rapidly subsiding basin was filled with over 2000 m of Permo-Pennsylvaniansediments. Stacked depositional sequences accumulated in three roughly parallel facies belts: anortheastern clastic belt (adjacent to uplift), a central salt and black shale belt, and asouthwestern carbonate belt. Over 400 million barrels of oil

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30

Liakhovitch, Evgueni. "Genetic algorithm using restricted sequence alignments." Ohio : Ohio University, 2000. http://www.ohiolink.edu/etd/view.cgi?ohiou1172598174.

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31

Philippe, Nicolas. "Développement de méthodes et d'algorithmes pour la caractérisation et l'annotation des transcriptomes avec les séquenceurs haut débit." Phd thesis, Université Montpellier II - Sciences et Techniques du Languedoc, 2011. http://tel.archives-ouvertes.fr/tel-00842810.

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Depuis leur apparition, les séquenceurs haut débit ont révolutionné l'étude des transcriptomes à l'échelle du génome. En effet, ils offrent la possibilité de générer des millions, voire des milliards de séquences, appelées reads. Des nouvelles approches transcriptomiques, telles que la Digital Gene Expression (DGE) et le RNA-Sequencing (RNA-Seq), permettent aujourd'hui de répertorier, de quantifier, voire reconstruire tous les transcrits d'une cellule, même les plus rares. Parmi ce type de transcrits se trouvent des ARN non-codants régulateurs ; des variants d'épissages créateurs de protéines

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32

Aniba, Mohamed Radhouane. "Knowledge based expert system development in bioinformatics : applied to multiple sequence alignment of protein sequences." Strasbourg, 2010. https://publication-theses.unistra.fr/public/theses_doctorat/2010/ANIBA_Mohamed_Radhouane_2010.pdf.

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L'objectif de ce projet de thèse a été le développement d'un système expert afin de tester, évaluer et d'optimiser toutes les étapes de la construction et l'analyse d'un alignement multiple de séquences. Le nouveau système a été validé en utilisant des alignements de référence et apporte une nouvelle vision pour le développement de logiciels en bioinformatique: les systèmes experts basés sur la connaissance. L'architecture utilisée pour construire le système expert est très modulaire et flexible, permettant à AlexSys d'évoluer en même temps que de nouveaux algorithmes seront mis à disposition.

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33

Wallis, Anne Elizabeth. "Identification of Leishmania genes encoding proteins containing tandemly repeating peptides." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/29447.

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In order to identify Leishmania proteins which may be immunologically relevant or may play a role in interactions between Leishmania and its mammalian host, a Leishmania major genomic DNA library was constructed in the vector λgt11 and screened with antibodies raised to Leishmania major promastigote membranes. Two recombinant DNA clones were identified which encoded repetitive sequences (Clone 20 and Clone 39). Clone 20 encoded a repetitive peptide of 14 amino acids and clone 39 encoded an unrelated repetitive peptide of 10 amino acids. Analysis of one of these clones, Clone 20, indicated that

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34

Lee, Hong-seng Daniel, and 李康善. "Foldback DNA: nucleotide sequence and characterization of MboII repeated sequences in human long foldbackDNA by molecular cloning and hybridization." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1987. http://hub.hku.hk/bib/B31231251.

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35

Dalmaso, Ricardo Curvello. "Identificação e caracterização de grupos de indivíduos segundo padrões de seqüências de atividades multidimensionais." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/3/3138/tde-21072009-144859/.

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O presente estudo procura identificar grupos homogêneos de indivíduos quanto aos padrões de seqüências de atividades diárias que estes realizam. As atividades são caracterizadas por múltiplos atributos, fazendo com que as seqüências sejam multidimensionais. Como atributos, ou características, são considerados a natureza da atividade realizada, ou motivo da viagem, e o período de realização da mesma, ambos separados em categorias. É estudado o efeito da inclusão da forma de acesso à atividade, ou modo de viagem, como uma terceira dimensão. Este atributo, entretanto, dados os resultados obtidos,

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36

Yu, Ning. "A Computational Tool for the Prediction of Small Non-coding RNAs in Genome Sequences." OpenSIUC, 2009. https://opensiuc.lib.siu.edu/theses/79.

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The purpose of researching bacterial gene expression is to control and prevent the diseases which are caused by bacteria. Recently researchers discovered small non-coding RNAs (ncRNA / sRNA) perform a variety of critical regulatory functions in bacteria. The genome-wide searching for sRNAs, especially the computational method, has become an effective way to predict the small non-coding RNAs because sRNAs have the consistent sequence characteristics. This article proposes a hybrid computational approach, HybridRNA, for the prediction of small non-coding RNAs, which integrates three critical tec

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37

Local, Andrea. "Cloning of Carbonic Anhydrase from Cotton (Gossypium hirsutum L.)." Thesis, University of North Texas, 1998. https://digital.library.unt.edu/ark:/67531/metadc279044/.

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Carbonic anhydrase is a ubiquitous zinc-metalloenzyme that catalyzes the interconversion of carbon dioxide and carbonate and has been found to play a wide range of roles in animals, plants and bacteria. Cotton genomic and cDNA libraries were screened for the plastidial isoform of carbonic anhydrase. The nucleotide sequences of two 1.2 Kb partial cDNA clones were determined. These clones exhibit high homology to carbonic anhydrases from other dicot plants and possess all the expected peptide motifs. For example, serine and threonine rich chloroplastic targeting peptide and conserved zinc bindin

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Almeida, André Atanasio Maranhão 1981. "Novas abordagens para o problema do alinhamento múltiplo de sequências." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/275646.

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Orientador: Zanoni Dias<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Computação<br>Made available in DSpace on 2018-08-22T15:29:14Z (GMT). No. of bitstreams: 1 Almeida_AndreAtanasioMaranhao_D.pdf: 2248939 bytes, checksum: b57ed5328b80a2fc7f36d1509558e756 (MD5) Previous issue date: 2013<br>Resumo: Alinhamento de seqüências é, reconhecidamente, uma das tarefas de maior importância em bioinformática. Tal importância origina-se no fato de ser uma operação básica utilizada por diversos outros procedimentos na área, como busca em bases de dados, visualização do efeito da e

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Lee, Hong-seng Daniel. "Foldback DNA : nucleotide sequence and characterization of MboII repeated sequences in human long foldback DNA by molecular cloning and hybridization /." [Hong Kong : University of Hong Kong], 1987. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12263643.

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Müller, Rodrigo Temp. "DESCRIÇÃO E POSICIONAMENTO FILOGENÉTICO DE UM NOVO ESPÉCIME DE SAUROPODOMORFA DA FORMAÇÃO CATURRITA." Universidade Federal de Santa Maria, 2016. http://repositorio.ufsm.br/handle/1/5332.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The present dissertation aims to present the osteological anatomy of an early sauropodomorph found in Triassic rocks from the municipality of Agudo, Rio Grande do Sul (RS), Brazil. In addition, it aims to tests the biostratigraphic utility of this specimen. CAPPA/UFSM 0002 is composed of postcranial elements from the locality called Sítio Wachholz, ascribed to the Caturrita Formation. Some typical features present in prosauropods are verified in the specimen. For instance, the concave caudal margin of the neural spines of the med

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Mallmann, Rafael Mendes. "Arquiteturas em hardware para o alinhamento local de sequências biológicas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/56841.

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Bancos de dados biológicos utilizados para comparação e alinhamento local de sequências tem crescido de forma exponencial. Isso popularizou programas que realizam buscas nesses bancos. As implementações dos algoritmos de alinhamento de sequências Smith- Waterman e distância Levenshtein demonstraram ser computacionalmente intensivas e, portanto, propícias para aceleração em hardware. Este trabalho descreve arquiteturas em hardware dedicado prototipadas para FPGA e ASIC para acelerar os algoritmos Smith- Waterman e distância Levenshtein mantendo os mesmos resultados obtidos por softwares. Descre

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Dew, Patrick. "SEQUENCE." Kent State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=kent1208712717.

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Kwasigroch, Jean-Marc. "Etude de faibles identites de sequences dans les proteines globulaires : proposition d'une taxonomie des boucles et etablissement d'une relation entre sequence et structure." Paris 6, 1996. http://www.theses.fr/1996PA066218.

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Une banque de boucles de trois a huit acides amines de long a ete constituee. D'une analyse statistique des conformations, il ressort que les boucles sont constituees de deux parties: les residus extremes, en contact avec les structures secondaires que la boucle relie, et l'interieur. Les conformations des residus de bord sont correlees a la nature de la structure secondaire voisine. Par contre, les residus centraux adoptent des conformations non correlees d'un residu au suivant. Le fort pourcentage de conformations a#l, principalement dues aux glycines et decroissant avec la taille de la bouc

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Agrawal, Ankit. "Sequence-specific sequence comparison using pairwise statistical significance." [Ames, Iowa : Iowa State University], 2009.

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Leonchiks, Ainars. "Regulation of protein degradation by virus derived repeated amino acid sequences /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-206-x/.

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Gregio, Bruno Chioderoli [UNESP]. "Sequências de números reais e as famosas constantes matemáticas e, π e ϕ". Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/150789.

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Submitted by BRUNO CHIODEROLI GREGIO null (brunogregio@hotmail.com) on 2017-05-30T23:45:02Z No. of bitstreams: 1 dissertação-versão-final.pdf: 1021988 bytes, checksum: c0924e4811037991cd26568ddd59ae7a (MD5)<br>Approved for entry into archive by Luiz Galeffi (luizgaleffi@gmail.com) on 2017-05-31T18:33:45Z (GMT) No. of bitstreams: 1 gregio_bc_me_sjrp.pdf: 1021988 bytes, checksum: c0924e4811037991cd26568ddd59ae7a (MD5)<br>Made available in DSpace on 2017-05-31T18:33:45Z (GMT). No. of bitstreams: 1 gregio_bc_me_sjrp.pdf: 1021988 bytes, checksum: c0924e4811037991cd26568ddd59ae7a (MD5) Previo

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Chia, Nicholas Lee-Ping. "Sequence alignment." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1154616122.

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48

Matthews, Trevor W. "In Sequence." Bowling Green State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1332165226.

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Garbett, Gary. "Insequential Sequence." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2277.

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Since childhood, my passion to create has driven me to search for the simplest truths within the world I live in. Throwbacks of pop culture have always decorated my life and their influences are directly reflected in my work. The nightly news, advertisements, pulp magazines, film, and music all play an extremely important role in my work as each influence becomes a layer of spirit and emotion in my mixed media paintings and photography. It’s those ordinary and mundane gifts that I find in each normal day that spill the truth and the essence of my life into my art. Popular culture has always fi

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Coccia, Marco Anthony. "Identification and cloning of amplified DNA sequences by a modified-in-gel renaturation technique: Isolation of an amplified DNA sequence from a human sarcoma." Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185368.

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A modified in gel renaturation technique has been developed which detects DNA sequence amplifications of ≥10-fold without prior identification of the target gene. In order to determine the sensitivity of detection and applicability of modified in gel renaturation, primary human tumor cultures and drug resistant human cell lines with identified cellular gene amplifications were assayed. The modified in gel renaturation technique was then used to screen 71 human tumor cell lines and direct tumor biopsies for amplified sequences. Particular emphasis was placed on screening cell lines derived from

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