Articoli di riviste: "Rockefeller Center (New York, N.Y.)"

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Cheng, Amanda, Caroline S. Jiang, Mireille McLean, Jan L. Breslow, Peter R. Holt, Rhonda G. Kost, Kimberly S. Vasquez et al. "2184". Journal of Clinical and Translational Science 1, S1 (settembre 2017): 70–71. http://dx.doi.org/10.1017/cts.2017.251.

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OBJECTIVES/SPECIFIC AIMS: To build a multisite deidentified database of female adolescents, aged 12–21 years (January 2011–December 2012), and their subsequent offspring through 24 months of age from electronic health records (EHRs) provided by participating Community Health. METHODS/STUDY POPULATION: We created a community-academic partnership that included New York City Community Health Centers (n=4) and Hospitals (n=4), The Rockefeller University, The Sackler Institute for Nutrition Science and Clinical Directors Network (CDN). We used the Community-Engaged Research Navigation model to establish a multisite deidentified database extracted from EHRs of female adolescents aged 12–21 years (January 2011–December 2012) and their offspring through 24 months of age. These patients received their primary care between 2011 and 2015. Clinical data were used to explore possible associations among specific measures. We focused on the preconception, prenatal, postnatal periods, including pediatric visits up to 24 months of age. RESULTS/ANTICIPATED RESULTS: The preliminary analysis included all female adolescents (n=49,292) and a subset of pregnant adolescents with offspring data available (n=2917). Patients were mostly from the Bronx; 43% of all adolescent females were overweight (22%) or obese (21%) and showed higher systolic and diastolic blood pressure, blood glucose levels, hemoglobin A1c, total cholesterol, and triglycerides levels compared with normal-weight adolescent females (p<0.05). There was a statistically significant association between the BMI status of mothers and infants’ birth weight, with underweight/normal-weight mothers having more low birth weight (LBW) babies and overweight/obese mothers having more large babies. The odds of having a LBW baby was 0.61 (95% CI: 0.41, 0.89) lower in obese compared with normal-weight adolescent mothers. The risk of having a preterm birth before 37 weeks was found to be neutral in obese compared to normal-weight adolescent mothers (OR=0.81, 95% CI: 0.53, 1.25). Preliminary associations are similar to those reported in the published literature. DISCUSSION/SIGNIFICANCE OF IMPACT: This EHR database uses available measures from routine clinical care as a “rapid assay” to explore potential associations, and may be more useful to detect the presence and direction of associations than the magnitude of effects. This partnership has engaged community clinicians, laboratory and clinical investigators, and funders in study design and analysis, as demonstrated by the collaborative development and testing of hypotheses relevant to service delivery.

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Tobin, Jonathan, Amanda Cheng, Caroline S. Jiang, Mireille McLean, Peter R. Holt, Dena Moftah, Rhonda G. Kost et al. "2229 A community-academic translational research and learning collaborative to evaluate the associations among biological, social, and nutritional status for adolescent women and their babies using electronic health records (EHR) data". Journal of Clinical and Translational Science 2, S1 (giugno 2018): 77–78. http://dx.doi.org/10.1017/cts.2018.272.

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OBJECTIVES/SPECIFIC AIMS: To build a multisite de-identified database of female adolescents, aged 12–21 years (January 2011–December 2012), and their subsequent offspring through 24 months of age from electronic health records (EHRs) provided by participating Community Health. METHODS/STUDY POPULATION: We created a community-academic partnership that included New York City Community Health Centers (n=4) and Hospitals (n=4), The Rockefeller University, The Sackler Institute for Nutrition Science and Clinical Directors Network (CDN). We used the Community-Engaged Research Navigation model to establish a multisite de-identified database extracted from EHRs of female adolescents aged 12–21 years (January 2011–December 2012) and their offspring through 24 months of age. These patients received their primary care between 2011 and 2015. Clinical data were used to explore possible associations among specific measures. We focused on the preconception, prenatal, postnatal periods, including pediatric visits up to 24 months of age. RESULTS/ANTICIPATED RESULTS: The analysis included all female adolescents (n=122,556) and a subset of pregnant adolescents with offspring data available (n=2917). Patients were mostly from the Bronx; 43% of all adolescent females were overweight (22%) or obese (21%) and showed higher systolic and diastolic blood pressure, blood glucose levels, hemoglobin A1c, total cholesterol, and triglycerides levels compared with normal-weight adolescent females (p<0.05). This analysis was also performed looking at the nonpregnant females and the pregnant females separately. Overall, the pregnant females were older (mean age=18.3) compared with the nonpregnant females (mean age=16.5), there was a higher percentage of Hispanics among the pregnant females (58%) compared with the nonpregnant females (43.9%). There was a statistically significant association between the BMI status of mothers and infants’ birth weight, with underweight/normal-weight mothers having more low birth weight (LBW) babies and overweight/obese mothers having more large babies. The odds of having a LBW baby was 0.61 (95% CI: 0.41, 0.89) lower in obese compared with normal-weight adolescent mothers. The risk of having a preterm birth before 37 weeks was found to be neutral in obese compared with normal-weight adolescent mothers (OR=0.81, 95% CI: 0.53, 1.25). Preliminary associations are similar to those reported in the published literature. DISCUSSION/SIGNIFICANCE OF IMPACT: This EHR database uses available measures from routine clinical care as a “rapid assay” to explore potential associations, and may be more useful to detect the presence and direction of associations than the magnitude of effects. This partnership has engaged community clinicians, laboratory, and clinical investigators, and funders in study design and analysis, as demonstrated by the collaborative development and testing of hypotheses relevant to service delivery. Furthermore, this research and learning collaborative is examining strategies to enhance clinical workflow and data quality as well as underlying biological mechanisms. The feasibility of scaling-up these methods facilitates studying similar populations in different Health Systems, advancing point-of-care studies of natural history and comparative effectiveness research to identify service gaps, evaluate effective interventions, and enhance clinical and data quality improvement.

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Vassari, Marissa. "Voila!: The Rockefeller Archive Center's Exhibit Creation Process". Collections: A Journal for Museum and Archives Professionals 14, n. 1 (marzo 2018): 95–106. http://dx.doi.org/10.1177/155019061801400105.

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The Rockefeller Archive Center (RAC) in Sleepy Hollow, New York, hosts groups ranging from foundation staff to college-level classes. Over the course of a year, the RAC hosts approximately 30 visiting groups that include from as few as 10 people to as many as 45. The aim is to engage visiting groups with the RAC's vast collections by creating hands-on, tailored exhibits. The RAC has created policies and procedures, exhibit guides, and workflow templates that allow for documentation of each exhibit and encourage inclusiveness and transparency among staff. Employing a new, standardized approach by using these tools has made all phases of the exhibit process more efficient and allows the RAC to provide a rich, immersive archival experience for visitors. This article offers a case study in standardized exhibit creation that may benefit professionals in other institutions who are seeking to develop work processes and policies without diminishing the visitor experience.

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Wolner, Edward W. "Design and Civic Identity in Cincinnati's Carew Tower Complex". Journal of the Society of Architectural Historians 51, n. 1 (1 marzo 1992): 35–47. http://dx.doi.org/10.2307/990639.

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John J. Emery's Carew Tower complex in Cincinnati, Ohio, was an unusual example in the 1920s of the congruence between progressive skyscraper design and planning on the one hand, and progressive social and political tendencies on the other. Although its massing and major ornamental motifs were derived from other work in the decade by French and American designers, it nevertheless exhibited a spatial and circulatory originality unmatched by office buildings, hotels, or mixed-use skyscrapers prior to Rockefeller Center. More fully than any other skyscraper development between 1920 and 1935, the Carew Tower complex integrated significant aspects of local history with the architectural sophistication and the large-scale technological and organizational innovations generally identified with New York City and Chicago. At the same time, in an era when boss rule and political patronage dominated the governments of most large American cities, Emery and the Carew Tower complex were integrally associated with the extensive programs of public works and governmental reforms instituted in Cincinnati between 1924 and 1936.

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Hoefer, Dina, Patricia S. Ruppert, Elizabeth Rausch-Phung, Elizabeth Dufort, Manisha Patel, Manisha Patel, Dylan Johns et al. "LB15. Measles Outbreak in New York State (NYS) Outside of New York City, 2018–2019". Open Forum Infectious Diseases 6, Supplement_2 (ottobre 2019): S999—S1000. http://dx.doi.org/10.1093/ofid/ofz415.2498.

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Abstract Background The United States is experiencing one of the largest and longest measles outbreaks since elimination was declared in 2000 and is at risk of losing this status. Most cases occurring in NYS were reported in undervaccinated communities. Methods We included all confirmed NYS measles cases (excluding NYC) from outbreak counties from October 1, 2018 to July 25, 2019. We used the CSTE measles case definition requiring an acute febrile rash illness and either laboratory confirmation or direct epidemiologic linkage to a lab-confirmed case. For each case, demographic and clinical characteristics were obtained. A medical record review was completed for those reported to have an encounter at a hospital, emergency department, or urgent care center. Results There were 371 cases of measles reported, including 11 internationally imported cases. Most occurred in Rockland county (n = 283); followed by Orange (n = 55), Westchester (n = 18), Sullivan (n = 14) and Greene (n = 1) (Figures 1 and 2). The median age was 5.5 years; 79% of all cases occurred among children younger than 18 years of age (Figure 3). Most cases (79%) had not received any doses of measles vaccine. Of the 371 cases, 263 (71%) were children who had received 0 doses of measles, mumps, rubella vaccine (MMR), 218 (83%) of whom were over 1 year of age (Table 1). There have been no deaths or documented cases of encephalitis. Twenty-eight (8%) patients were diagnosed with pneumonia and 25 (7%) patients were hospitalized. Among 17 hospitalized children, 5 (29%) were admitted to the intensive care unit (ICU) (ages 1 day to 7 years). There were two preterm births at 34 and 25 weeks gestation to women with measles while pregnant. During October 1, 2018–July 31, 2019, providers in outbreak counties vaccinated 72,465 individuals with MMR, a 46% increase from the same period the year prior. Conclusion Unvaccinated children were identified as the largest group affected and experienced severe complications; nearly 30% of hospitalized children were admitted to an ICU. These data support the critical need for continued education and outreach on the risks of measles and the value of vaccination to prevent continued circulation in undervaccinated communities and potential further cases of severe disease. Disclosures Kirsten St. George, MAppSc, PhD, Akonni Biosystems (Other Financial or Material Support), ThermoFisher (Grant/Research Support), Zeptometrix (Other Financial or Material Support, royalty generating collaborative agreement); others, no disclosures reported..

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Fakundiny, Robert. "The New York State Museum: Child of the Geological Survey that Grew to be its Guardian". Earth Sciences History 6, n. 1 (1 gennaio 1987): 125–33. http://dx.doi.org/10.17704/eshi.6.1.9w66h2g183510672.

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The New York State Museum was created by State legislation in 1870 out of the old State Cabinet, which held the specimens collected by the State Geological and Natural History Survey, James Hall, then State Geologist and Palaeontologist within the Survey, was named Director of the Museum. Hall's need to possess and study vast quantities of paleontological specimens required space for collections storage and processing. His collections became the major supply of specimens for the Cabinet and eventually the Museum. After the original Survey was disbanded, in the early 1840's, Hall's presence gave the Cabinet a definite geological character. As the chief geological scientist, Hall considered the geological research of the Cabinet and later the Museum as a product of the "Geological Survey of New York," even though no formal designation of such a unit was ever proclaimed by state legislation. After all, other states were forming geological research units similar to Hall's and calling them geological surveys. It made sense for good communications for Hall and his predecessor State Geologists to refer to their staff as the New York State Geological Survey. Eventually, through a series of other legislative acts, most importantly in 1904 and 1945, the Museum was made the formal administrative home for the Geological Survey and, thus, its guardian. Museum Directors, therefore, have had the principle role in determining the fate of geological and paleontological research within the Geological Survey, After 1926, when the first non-geologist became director, the Museum's research scope grew faster in other natural and social history areas, such as botany, entomology, zoology, archaeology, ethnology, and history. This expansion is exemplified by the addition of a State Historian to the Education Department in 1895. During its 150-year history the Geological Survey has moved six times, and it is now housed in the Cultural Education Center in the Governor Nelson A. Rockefeller Empire State Plaza, Albany, New York.

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Prigoff, Jake, Grace Hillyer, Fletcher Bell e Melissa Kate Accordino. "Effects of COVID-19 on an academic breast oncology center in New York City." Journal of Clinical Oncology 38, n. 29_suppl (10 ottobre 2020): 51. http://dx.doi.org/10.1200/jco.2020.38.29_suppl.51.

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51 Background: The influx of patients to the healthcare system due to COVID-19 impacted healthcare practices including the care of breast cancer patients. Our aim is to describe the impact this pandemic had on breast cancer care delivery at an academic center in NYC to inform policy and procedure for future crises that limit patient access to on-site facilities. Methods: A survey was sent to physicians involved in the care of patients with breast cancer at Columbia University Irving Medical Center in May 2020. Participants were asked about practice structure and changes to breast cancer care. The primary outcome was the degree that providers believed breast oncology patients’ clinical outcomes were significantly impacted by COVID-19. Secondary outcomes included changes in diagnostic and management approaches and advice for future providers faced with a similar pandemic. Results: The response rate was 65.4% (17/26). This included physicians from medical oncology (n = 7), radiology (n = 4), breast surgery (n = 3), radiation oncology (n = 2), and plastic surgery (n = 1). Seventy-six percent of physicians somewhat agreed, agreed, or strongly agreed that oncologic outcomes may be significantly impacted by the COVID-19 pandemic. Nearly half (47%) of respondents reported delays in the workup of patients due to COVID-19 with 50.0% for mammograms, 47.5% for bone scans, 46.0% for ultrasounds, 43.8% for PET scans, and 43.3% for biopsies. Eighty-two percent reported delays in overall oncologic management. Delays to systemic therapy were: intravenous/targeted therapy (37.9%), intramuscular/subcutaneous endocrine therapy (28.3%), oral chemotherapy/targeted therapy (22.9%), and oral endocrine therapy (12.8%). Delays to local therapy were: surgery (64.4%) and radiation therapy (44.6%). Almost two-thirds (64.7%) reported it necessary to use alternative oncologic management strategies. The most common piece of advice our providers offered was to increase testing capacity to all patients, especially when coming to a healthcare facility. Conclusions: The COVID-19 pandemic has caused major disruption to breast cancer practices. Breast oncology physicians reported delays in management in over 80% of patients, and the need to use alternative management strategies in over 60% of patients. Effects of these disruptions on oncologic outcomes are unknown, but over 75% of our physicians believe this will significantly impact breast oncology patients’ outcomes. There's a need for policies and procedures to structure patient care should there be a future crisis that limits patient access to oncologic care.

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John, Kose, e Joshua Ronen. "Information Structures, Optimal Contracts and the Theory of the Firm". Journal of Accounting, Auditing & Finance 5, n. 1 (gennaio 1990): 61–95. http://dx.doi.org/10.1177/0148558x9000500106.

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We are grateful for comments made by participants at the Symposium on the “Measurement of Profit and Productivity: Theory and Practice,” on December 16, 1988, in the University of Florida, cosponsored by the Vincent C. Ross Institute of Accounting Research, Leonard N. Stern School of Business, New York University, the Public Policy Research Center, Graduate School of Business, University of Florida, and The Kruger Center of Finance, Jerusalem School of Business Administration, Hebrew University; at workshops at the Leonard M. Stern School of Business, New York University; at the Accounting Research and Education Center of McMaster University; at the European Accounting Association meeting in Stuttgart, Germany; at workshops at Wharton School University of Pennsylvania; University of California at Berkeley; Northwestern University; French Finance Association Meeting.

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Schene, M. G. "Worthwhile Places: Correspondence of John D. Rockefeller, Jr. and Horace M. Albright. Edited by Joseph W. Ernst. Bronx, New York: Fordham University Press for Rockefeller Archive Center, 1991. 354 pp. Illustrations, maps, sources, further reading, index. Paper $19.95". Forest & Conservation History 37, n. 1 (1 gennaio 1993): 38–39. http://dx.doi.org/10.2307/3983820.

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Hanson, Melissa, Nicholas Hollingshead, Krysten Schuler, William F. Siemer, Patrick Martin e Elizabeth M. Bunting. "Species, causes, and outcomes of wildlife rehabilitation in New York State". PLOS ONE 16, n. 9 (21 settembre 2021): e0257675. http://dx.doi.org/10.1371/journal.pone.0257675.

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Wildlife rehabilitation is a publicly popular practice, though not without controversy. State wildlife agencies frequently debate the ecological impact of rehabilitation. By analyzing case records, we can clarify and quantify the causes for rehabilitation, species involved, and treatment outcomes. This data would aid regulatory agencies and rehabilitators in making informed decisions, as well as gaining insight into causes of species mortality. In New York State, the Department of Environmental Conservation (NYSDEC) has licensed rehabilitators since 1980 and annual reporting is required. In this study, we analyzed 58,185 individual wildlife cases that were attended by New York rehabilitators between 2012 and 2014. These encompassed 30,182 (51.9%) birds, 25,447 (43.7%) mammals, 2,421 (4.2%) reptiles, and 75 (0.1%) amphibians. We identified patterns among taxonomic representation, reasons for presentation to a rehabilitation center, and animal disposition. Major causes of presentation were trauma (n = 22,156; 38.1%) and orphaning (n = 21,679; 37.3%), with habitat loss (n = 3,937; 6.8%), infectious disease (n = 1,824; 3.1%), and poisoning or toxin exposure (n = 806; 1.4%) playing lesser roles. The overall release rate for animals receiving care was 50.2% while 45.3% died or were euthanized during the rehabilitation process. A relatively small number (0.3%) were permanently non-releasable and placed in captivity; 4.1% had unknown outcomes. A comparable evaluation in 1989 revealed that wildlife submissions have increased (annual mean 12,583 vs 19,395), and are accompanied by a significant improvement in release (50.2% in the study period vs 44.4% in 1989) (χ2(1) = 90.43, p < 0.0001). In this manuscript, we aim to describe the rehabilitator community in New York State, and present the causes and outcomes for rehabilitation over a three-year period.

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Kao, Frederick F. "Editorial: The Impact of Chinese Medicine on America". American Journal of Chinese Medicine 20, n. 01 (gennaio 1992): 1–16. http://dx.doi.org/10.1142/s0192415x92000023.

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As a Chinese American born in Peking and educated both in China and in the United States, the author has, for several decades, been interested in the impact of Chinese culture, including medicine, on American society. While holding a professorship in physiology and biophysics at the State University of New York, Downstate Medical Center, the author began to teach a course on Chinese medical history in the early 1960s. In 1972, he founded the Institute for Advanced Research in Asian Science and Medicine (IARASM) which publishes the American Journal of Chinese Medicine, holds international conferences for scholars and physicians interested in indigenous medical systems, trains physicians for acupuncture therapy, and fosters centers for urban primary health care. The author is a member of the World Health Organization's Expert Advisory Panel on Traditional Medicine. He is the Editor-in-Chief of the American Journal of Chinese Medicine which now reaches an audience in 45 countries. The IARASM is a World Health Organization Collaborating Center for Traditional Medicine. The author served on the Rockefeller Commission of New York State on Acupuncture in 1973, and, in the same year, served as a panel member of the National Institutes of Health Conference on Acupuncture. He visited China at the invitation of the Ministry of Public Health of the People's Republic of China or WHO in 1973, 1974, 1977, 1978, 1979, 1980, 1984, and 1987 when he chaired meetings and lectured to faculty of several medical schools. The author envisages that the process of integration of all indigenous medicines of various cultures will end in the 21st century, at which time the "ecumenical medicine" - a term first used by Joseph Needham - movement will not be necessary, for all forms of medicine will be one system. The author has a great interest in the furtherance of indigenous medicine and their integration into one system, but his views and observations, as all endeavors in humanity, are not infallible.

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Pardos de la Gandara, Maria, Juan Antonio Raygoza Garay, Michael Mwangi, Jonathan N. Tobin, Amanda Tsang, Chamanara Khalida, Brianna D'Orazio et al. "Molecular Types of Methicillin-Resistant Staphylococcus aureus and Methicillin-Sensitive S. aureus Strains Causing Skin and Soft Tissue Infections and Nasal Colonization, Identified in Community Health Centers in New York City". Journal of Clinical Microbiology 53, n. 8 (10 giugno 2015): 2648–58. http://dx.doi.org/10.1128/jcm.00591-15.

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In November 2011, The Rockefeller University Center for Clinical and Translational Science (CCTS), the Laboratory of Microbiology and Infectious Diseases, and Clinical Directors Network (CDN) launched a research and learning collaborative project with six community health centers in the New York City metropolitan area to determine the nature (clonal type) of community-acquiredStaphylococcus aureusstrains causing skin and soft tissue infections (SSTIs). Between November 2011 and March 2013, wound and nasal samples from 129 patients with active SSTIs suspicious forS. aureuswere collected and characterized by molecular typing techniques. In 63 of 129 patients, the skin wounds were infected byS. aureus: methicillin-resistantS. aureus(MRSA) was recovered from 39 wounds and methicillin-sensitiveS. aureus(MSSA) was recovered from 24. Most—46 of the 63–wound isolates belonged to the CC8/Panton-Valentine leukocidin-positive (PVL+) group ofS. aureusclone USA300: 34 of these strains were MRSA and 12 were MSSA. Of the 63 patients withS. aureusinfections, 30 were also colonized byS. aureusin the nares: 16 of the colonizing isolates were MRSA, and 14 were MSSA, and the majority of the colonizing isolates belonged to the USA300 clonal group. In most cases (70%), the colonizing isolate belonged to the same clonal type as the strain involved with the infection. In three of the patients, the identity of invasive and colonizing MRSA isolates was further documented by whole-genome sequencing.

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MEHRLING, PERRY. "AN INTERVIEW WITH PAUL A. VOLCKER". Macroeconomic Dynamics 5, n. 3 (giugno 2001): 434–60. http://dx.doi.org/10.1017/s1365100500020058.

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Paul A. Volcker has spent most of his life in public service, at the Treasury under President Kennedy (1962–1965) and then as Undersecretary for Monetary Affairs under President Nixon (1969–1974), as President of the Federal Reserve Bank of New York (1975–1979), and finally as Chairman of the Board of Governors of the Federal Reserve System under both President Carter and President Reagan (1979–1987). Born in 1927, his world view was formed by childhood experience of the Great Depression and World War II, times of great national trial that led ultimately to recommitment and reconstruction. He went into public service in order to be a part of the rebuilding effort, but it was his fate instead to be involved mainly in managing pressures that would ultimately lead to the breakdown of the Bretton Woods system internationally and the Glass–Steagall banking system domestically. Consequently, there is some sadness today when he looks back on his career, but there is also a sense of accomplishment. In spite of everything, there was no depression and there was no world war. The possibility and hope for progress in years to come remains alive.The interview took place in Volcker's office at Rockefeller Center in New York City. His fourth-floor windows look out over the sunken plaza to the gold-leafed statue of Prometheus stealing fire from the gods, and then on farther to the elegant GE building, which is familiar to anyone who has visited New York. Over the front entrance it is just possible to see the inscription adapted from Isaiah 33:6, “Wisdom and Knowledge shall be the stability of thy times.” It strikes me as an appropriate inscription for the building, reminding one that this most beautiful complex was built in the years of the Great Depression. Today, with the forthcoming interview in mind, it reminds me also of the stakes involved in the conduct of monetary policy.

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Fox, Cybelle. "“The Line Must Be Drawn Somewhere”: The Rise of Legal Status Restrictions in State Welfare Policy in the 1970s". Studies in American Political Development 33, n. 02 (25 settembre 2019): 275–304. http://dx.doi.org/10.1017/s0898588x19000129.

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In 1971, Governor Ronald Reagan signed into law a measure barring unauthorized immigrants from public assistance. The following year, New York State legislators passed a bill to do the same, although that bill was vetoed by Governor Nelson Rockefeller. This article examines these cases to better understand why states that had long provided welfare to unauthorized immigrants each sought to bar them from public assistance. Common explanations for the curtailment of immigrant social rights often center on partisan politics, popular nativism, demographic context, or issue entrepreneurs. But these studies often wrongly assume that efforts to limit immigrant social rights began in the 1990s. Therefore, they miss how such efforts first emerged in the 1970s, and how these restrictive measures were initially closely bound up in broader debates over race and welfare that followed in the wake of the War on Poverty and the civil rights movement. Where scholars often argue that immigration undermines support for welfare, I show how the turn against welfare helped to undermine immigrant social rights. I also show how differing interpretations of the scope and reach of Supreme Court decisions traditionally seen as victories for welfare and immigrant rights help explain initial variation in policy outcomes in each state.

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Hottensen, Dory. "Bereavement: Caring for Families and Friends after a Patient Dies". OMEGA - Journal of Death and Dying 67, n. 1-2 (agosto 2013): 121–26. http://dx.doi.org/10.2190/om.67.1-2.n.

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New York-Presbyterian Hospital/Weill Cornell Medical Center is a large academic medical center that provided minimal, if any, bereavement support to families and loved ones of patients who died in the hospital. A comprehensive bereavement program was developed and implemented which included sending condolence cards to family members and friends, follow-up phone calls to screen for complicated grief, individual counseling, bereavement support groups, community referrals, and an annual memorial service for families and staff to provide an opportunity for shared mourning during the grieving process.

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Hasan, Shaakir, Robert H. Press, Arpit Chhabra, J. Isabelle Choi e Charles B. Simone. "Longitudinal Quantitative Analysis of Radiation Oncology Staff Illness in a New York City Center during COVID-19: The Impact of New Guidelines on Operations and Employee Health". International Journal of Particle Therapy 7, n. 1 (1 giugno 2020): 21–27. http://dx.doi.org/10.14338/ijpt-20-00032.1.

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Abstract Purpose The novel coronavirus (COVID-19) forced radiation oncology clinics to overhaul operational policies, but the effect on employee safety has not, to our knowledge, been reported. The New York Proton Center (NYPC), a large freestanding clinic in New York City, New York, presents a 1-month experience of employee-reported health outcomes after the infiltration of COVID-19 and enforcement of policies designed to mitigate its impact. Materials and Methods In March 2020, new operational policies were implemented, including rigorous and frequent sanitation, visitor and treatment restrictions, distribution of personal protective equipment, work-from-home orders, and isolated nursing and radiation therapy teams. Employees of NYPC were prospectively monitored for exposure and symptoms of COVID-19. Work hours lost because of illness or quarantines were quantified from March 1, 2020, to March 31, 2020. Results Among 95 total employees, 23 (24%) were quarantined because of symptoms (n = 15; 65%), high-risk exposure (n = 5; 22%), or self-quarantined with personal concern (n = 3; 13%). Of 44 full-time, on-site employees, 39% (n = 17, including 6 therapists and 5 nurses) missed significant work time, including 6 (14%) with confirmed COVID-19. At full capacity, NYPC would have used 7260 work hours during March 2020 from the full-time, on-site staff, which was reduced by 18.8% overall (25.2% of nursing and 13.3% of therapy work hours), all in the latter half of the month. Among the therapist lost work hours, 92% were from 2 of 7 distinct, isolated therapy teams (29%). Without isolation, the exposure was modeled to have been 100%. Conclusion Despite losing significant staff hours in our department because of COVID-19, early and aggressive adoption of current, recommended policy guidelines outlined in this manuscript allowed NYPC to continue patient operations at full capacity.

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Yung, Janette, Jiehui Li, Rebecca D. Kehm, James E. Cone, Hilary Parton, Mary Huynh e Mark R. Farfel. "COVID-19-Specific Mortality among World Trade Center Health Registry Enrollees Who Resided in New York City". International Journal of Environmental Research and Public Health 19, n. 21 (2 novembre 2022): 14348. http://dx.doi.org/10.3390/ijerph192114348.

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We examined the all-cause and COVID-19-specific mortality among World Trade Center Health Registry (WTCHR) enrollees. We also examined the socioeconomic factors associated with COVID-19-specific death. Mortality data from the NYC Bureau of Vital Statistics between 2015–2020 were linked to the WTCHR. COVID-19-specific death was defined as having positive COVID-19 tests that match to a death certificate or COVID-19 mentioned on the death certificate via text searching. We conducted step change and pulse regression to assess excess deaths. Limiting to those who died in 2019 (n = 210) and 2020 (n = 286), we examined factors associated with COVID-19-specific deaths using multinomial logistic regression. Death rate among WTCHR enrollees increased during the pandemic (RR: 1.70, 95% CL: 1.25–2.32), driven by the pulse in March–April 2020 (RR: 3.38, 95% CL: 2.62–4.30). No significantly increased death rate was observed during May–December 2020. Being non-Hispanic Black and having at least one co-morbidity had a higher likelihood of COVID-19-associated mortality than being non-Hispanic White and not having any co-morbidity (AOR: 2.43, 95%CL: 1.23–4.77; AOR: 2.86, 95%CL: 1.19–6.88, respectively). The racial disparity in COVID-19-specific deaths attenuated after including neighborhood proportion of essential workers in the model (AOR:1.98, 95%CL: 0.98–4.01). Racial disparities continue to impact mortality by differential occupational exposure and structural inequality in neighborhood representation. The WTC-exposed population are no exception. Continued efforts to reduce transmission risk in communities of color is crucial for addressing health inequities.

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Obata, Reiichiro, Tetsuro Maeda, Dahlia Rizk e Toshiki Kuno. "Palliative Care Team Involvement in Patients With COVID-19 in New York City". American Journal of Hospice and Palliative Medicine® 37, n. 10 (8 luglio 2020): 869–72. http://dx.doi.org/10.1177/1049909120940986.

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Background: With the highest number of cases in the world as of April 13, 2020, New York City (NYC) became the epicenter of the global coronavirus disease 2019 (COVID-19) pandemic. The data regarding palliative team involvement in patients with COVID-19, however, remains scarce. We aimed to investigate outcomes of palliative team involvement for the patients with COVID-19 in NYC. Methods: Consecutive 225 patients with confirmed COVID-19 requiring hospitalization in our urban academic medical center in NYC were analyzed. Patients were divided into 2 groups, those with a palliative care consult (palliative group: 14.2% [n = 32]) versus those with no palliative care consult (no palliative group: 85.8% [n = 193]). Results: The palliative group was older and had more comorbidities. During the hospital course, the palliative group had more intensive care unit stays, rapid response team activations, and more use of vasopressors ( P < .05). Patients with palliative care had higher rates of invasive mechanical ventilation than those without (46.9% vs 10.4%, P < .001). Cardiopulmonary resuscitation was performed in 12 patients (6.5% vs 5.2%, P = .77) and death rate was 100% in both subsets. Notably, initial code status was not different between the 2 groups, however, code status at discharge was significantly different between them ( P < .001). The rate of full code decreased by 70% in the palliative group and by 47.5% in the no palliative care group from admission to the time of death. Conclusions: Critically ill patients hospitalized for COVID-19 benefit from palliative team consults by helping to clarify advanced directives and minimize futile resuscitative efforts.

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Keleş, Ruşen. "The periphery in the center: Some political features of Turkish urbanization". Ekistics and The New Habitat 70, n. 420/421 (1 agosto 2003): 211–17. http://dx.doi.org/10.53910/26531313-e200370420/421288.

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The author taught at Ankara University; Faculty of Political Science for many years and served as Dean of the Faculty during 1971- 1975. He was also the Head of both the Ernst Reuter Center for Urban Studies and the Center for Environmental Studies in the same university. He is currently teaching at the Eastern Mediterranean University, North Cyprus. Dr Keleę has published extensively on Comparative Urbanization, Theories of Local Government, Environmental Policies, and Urban Politics. His major publications include The Politics of Urbanization: Government and Growth in Modern Turkey (with Michael N. Danielson, New York, Holmes and Meier, 1985); The Urban Poverty in the Third World, Institute of Developing Economies, Tokyo, 1988; and Housing in the Middle East (with Hiromaso Kano), Institute of Developing Economies, Tokyo, 1986.

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DAVIS, L. J., H. L. ROBERTS, D. D. JURANEK, S. R. FRAMM e R. SOAVE. "A survey of risk factors for cryptosporidiosis in New York City: drinking water and other exposures". Epidemiology and Infection 121, n. 2 (ottobre 1998): 357–67. http://dx.doi.org/10.1017/s095026889800123x.

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We conducted a survey to determine the prevalence of known and theoretical exposure risks for cryptosporidiosis among selected New York City residents. Subjects were recruited from outpatients attending either a practice for persons with HIV infection (n=160), or other medical practices (n=153), at The New York Hospital–Cornell Medical Center. Despite a greater concern for waterborne infection, 82% of HIV-infected subjects reported consuming municipal tap water compared to 69% of subjects from other medical clinics (OR 2·1, 95% CI 1·2–3·6, P=0·006). Although 18% and 31% of subjects, respectively, denied any tap water consumption at home or work, all but one from each cohort responded positively to having at least one possible alternate source of tap water ingestion such as using tap water to brush teeth or drinking tap water offered in a restaurant. 78% and 76% of subjects, respectively, had at least one potential risk for exposure other than municipal water consumption, such as swimming in pools or contact with animals. Our findings indicate that it is possible to stratify the population into subsets by the amount of tap water consumed. This suggests that an observational epidemiologic study of the risk of contracting cryptosporidiosis from everyday tap water consumption is feasible.

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Bilfinger, Thomas, Allison Nemesure, Robert Pyo, Jonathan Weinstein, Giridhar Korlipara, Daniel Montellese, Shamim Khan et al. "Distressed Communities Index in Patients Undergoing Transcatheter Aortic Valve Implantation in an Affluent County in New York". Journal of Interventional Cardiology 2021 (24 agosto 2021): 1–8. http://dx.doi.org/10.1155/2021/8837644.

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Background. The clinical impact of the distressed communities index (DCI), a composite measure of economic well-being based on the U.S. zip code, is becoming increasingly recognized. Ranging from 0 (prosperous) to 100 (distressed), DCI’s association with cardiovascular outcomes remains unknown. We aimed to study the association of the DCI with presentation and outcomes in adults with severe symptomatic aortic stenosis (AS) undergoing transcatheter aortic valve intervention (TAVR) in an affluent county in New York. Methods. The study population included 286 patients with severe symptomatic AS or degeneration of a bioprosthetic valve who underwent TAVR with a newer generation transcatheter heart valve (THV) from December 2015 to June 2018 at an academic tertiary medical center. DCI for each patient was derived from their primary residence zip code. Patients were classified into DCI deciles and then categorized into 4 groups. The primary and secondary outcomes of interest were 30-day, 1-year, and 3-year mortality, respectively. Results. Among 286 patients studied, 26%, 28%, 28%, and 18% were categorized into DCI groups 1–4, respectively (DCI <10: n = 73; DCI 10–20: n = 81; DCI 20–30: n = 80; DCI >30: n = 52). Patients in group 4 were younger with worse kidney function compared to patients in groups 1 and 2. They also had smaller aortic annuli and were more likely to receive a smaller THV. No significant difference in hospital length of stay or distribution of in-hospital, 30-day, 1-year, and 3-year mortality was demonstrated. Conclusions. While the DCI was associated with differences in the clinical and anatomic profile, it was not associated with differences in clinical outcomes in this prospective observational study of adults undergoing TAVR suggesting that access to care is the likely discriminator.

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Bloch, Rebecca A., Grace Faulkner, Elizabeth D. Hilborn, Tina Wismer, Nicole Martin e Sarah Rhea. "Geographic Variability, Seasonality, and Increase in ASPCA Animal Poison Control Center Harmful Blue-Green Algae Calls—United States and Canada, 2010–2022". Toxins 15, n. 8 (15 agosto 2023): 505. http://dx.doi.org/10.3390/toxins15080505.

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Harmful cyanobacteria (blue-green algae) exposures can cause illness or death in humans and animals. We characterized American Society for the Prevention of Cruelty to Animals (ASPCA) Animal Poison Control Center (APCC) harmful blue-green algae (HBGA) call data, compared it to a measure of harmful algal bloom public awareness, and considered its suitability as a public health information source. ASPCA APCC dog and cat “HBGA exposure” calls made 1 January 2010–31 December 2022 were included. We calculated annual HBGA call percentages and described calls (species, month, origin, exposure route). We characterized public awareness by quantifying Nexis Uni® (LexisNexis Academic; New York, NY, USA)-indexed news publications (2010–2022) pertaining to “harmful algal bloom(s)”. Call percentage increased annually, from 0.005% (2010) to 0.070% (2022). Of 999 HBGA calls, 99.4% (n = 993) were dog exposures. Over 65% (n = 655) of calls were made July–September, largely from the New England (n = 154 (15.4%)) and Pacific (n = 129 (12.9.%)) geographic divisions. Oral and dermal exposures predominated (n = 956 (95.7%)). Harmful algal bloom news publications increased overall, peaking in 2019 (n = 1834). Higher call volumes in summer and in the New England and Pacific geographic divisions drove HBGA call increases; public awareness might have contributed. Dogs and humans have similar exposure routes. ASPCA APCC HBGA call data could serve as a public health information source.

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Malapi-Wight, M., J. B. Hébert, R. Buckley, M. L. Daughtrey, N. F. Gregory, K. Rane, S. Tirpak e J. A. Crouch. "First Report of Boxwood Blight Caused byCalonectria pseudonaviculatain Delaware, Maryland, New Jersey, and New York". Plant Disease 98, n. 5 (maggio 2014): 698. http://dx.doi.org/10.1094/pdis-10-13-1102-pdn.

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Boxwood (Buxus spp.) are commercially important evergreen ornamental plants with an annual market value of over $103 million in the United States. The recent U.S. incursion of boxwood blight disease caused by the fungus Calonectria pseudonaviculata (syn. Cylindrocladium pseudonaviculatum, Cy. buxicola) threatens the health and productivity of boxwood in both landscape plantings and nurseries. The first confirmed U.S. reports of the disease were made from Connecticut and North Carolina in November 2011 (2,4), followed by diagnoses in 10 additional states during 2012 and 2013. By August 2013, symptoms consistent with boxwood blight had been observed from B. sempervirens in Delaware, Maryland, New Jersey, and southeastern New York. Affected plants showed rapid onset of disease symptoms: dark brown to black spots or diffuse dark areas on leaves, followed by defoliation. Narrow, elongate black cankers also formed on current season shoots. Symptomatic stems and leaves were placed in petri dishes with moistened filter paper at 22°C for 3 days under continuous light. Conidiophores were excised, then placed on potato dextrose agar amended with streptomycin and neomycin (0.3 g/l). Resultant colonies showed dark brown pigmentation at the colony center surrounded by tan to reddish brown rings with white mycelia at the advancing edge. Conidia (n = 30 per isolate) were hyaline, cylindrical, rounded at both ends, with a single septum (45 to 76 × 4 to 6 μm; avg. 63 × 5 μm). Conidiophores (n = 20 per isolate) comprised a stipe, a hyaline septate stipe extension (length 119 to 192 μm; avg. 150 μm) and a terminal ellipsoidal vesicle (diameter 4 to 10 μm; avg. 7 μm). Based on morphological characteristics, the causal agent was identified as C. pseudonaviculata (1,4). Voucher specimens were deposited in the U.S. National Fungus Collections (BPI 892698 to 701). To verify morphological diagnosis, genomic DNA was extracted from fungal biomass grown in liquid cultures of yeast extract peptone dextrose media. A portion of the β-tubulin gene (TUB2) was PCR amplified and sequenced bi-directionally using primers Bta/Bt2b (3). BLASTn searches of NCBI GenBank databases using the TUB2 sequences (Accession Nos. KF785808 to 11) demonstrated 96 to 100% sequence identity with other C. pseudonaviculata isolates. To confirm pathogenicity, 5-month-old B. sempervirens and B. microphylla seedlings were spray-inoculated with a spore suspension of 1 × 104conidia/ml. One isolate from each state was independently tested with four replicates each. Non-inoculated water-sprayed plants served as negative controls. Plants were maintained in growth chambers at 22°C under constant light. Blight symptoms developed 4 to 5 days post inoculation. C. pseudonaviculata was re-isolated from inoculated plants; no symptoms or signs were observed from control plants. To our knowledge, this is the first report of C. pseudonaviculata in the states of Delaware, Maryland, New Jersey, and New York. This report demonstrates that C. pseudonaviculata is now widespread across the United States eastern seaboard, and represents a substantial threat to boxwood plants in North American landscapes and nurseries.References: (1) P. Crous et al. Sydowia 54:23, 2002. (2) D. F. Farr and A. Y. Rossman. Fungal Databases, USDA-ARS. Retrieved from http://nt.ars-grin.gov/fungaldatabases , 30 August 2013. (3) N. L. Glass and G. C. Donaldson. Appl. Environ. Microbiol. 61:1323, 1995. (4) K. L. Ivors et al. Plant Dis. 96:1070, 2012.

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Hoepting, C. A., H. F. Schwartz e H. R. Pappu. "First Report of Iris yellow spot virus on Onion in New York". Plant Disease 91, n. 3 (marzo 2007): 327. http://dx.doi.org/10.1094/pdis-91-3-0327a.

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Iris yellow spot virus (IYSV [family Bunyaviridae, genus Tospovirus]), a potentially devastating disease of onion vectored by onion thrips (Thrips tabaci Lindeman), has been reported from most states in the western United States where significant onion production occurs, with the most recent report from Texas (1). In June 2006, volunteer onion (Allium cepa) plants in Orleans County, New York (Elba muckland) were found to have symptoms indicative of IYSV infection. The scapes (seed stalks) of the volunteer onions found at the edge of a cull pile from a 2005 onion crop exhibited diamond-shaped lesions, each with a distinct green center and a double yellow border. Approximately 25 of 100 plants of red and yellow onion cultivars exhibited characteristic IYSV lesions. The cull pile was composed primarily of locally grown onions, although a few of the bulbs were grown from imported bare-root transplants imported from Arizona. Symptomatic plants tested positive for IYSV using IYSV-specific antiserum from Agdia Inc. (Elkhart, IN) in a double-antibody sandwich-ELISA. The presence of IYSV was verified by reverse transcription (RT)-PCR using primers derived from the small RNA of IYSV (S-RNA). The primers flanked the IYSV nucleocapsid (N) gene (5′-TAA AAC AAA CAT TCA AAC AA-3′ and 5′-CTC TTA AAC ACA TTT AAC AAG CAC-3′ (3). RT-PCR assays produced a PCR amplicon of expected size (approximately 1.2 kb) and the product was cloned and sequenced. Nucleotide sequence analysis confirmed the identity of the amplicon as that of the IYSV S-RNA. Sequence comparisons showed 95 to 98% identity with known IYSV N gene sequences available in GenBank. The virus is poorly transmitted to onion by mechanical inoculation and we did not have access to a noninfested colony of the onion thrips vector to transfer the virus from these samples to noninfected onions. No asymptomatic plants were tested. Among the onion-growing states in the eastern United States, IYSV has previously only been reported from Georgia (2). To our knowledge, this is the first report of IYSV in New York and the greater northeastern United States. The finding of this disease in New York confirms further spread of the virus within North America and the need for research to develop more effective management options to reduce the impact of IYSV on onion crops. References: (1) M. Miller et al. Plant Dis. 90:1359, 2006. (2) S. W. Mullis et al. Plant Dis. 90:377, 2006. (3) H. R. Pappu et al. Arch. Virol. 151:1015, 2006.

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Marcos, Luis, Kalie Smith, Fredric Weinbaum e Eric Spitzer. "667. An Emerging Tick-Borne Disease in Long Island, New York: Relapsing Fever Caused by Borrelia miyamotoi". Open Forum Infectious Diseases 5, suppl_1 (novembre 2018): S241. http://dx.doi.org/10.1093/ofid/ofy210.674.

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Abstract Background Suffolk County (Long Island, New York) reports annually the highest absolute number of tick-borne diseases in New York. A new Borrelia species, Borrelia miyamotoi which causes a relapsing fever, has been reported in New York recently. The aim of this study was to identify the number of cases of B. miyamotoi diagnosed in Suffolk county. Methods A retrospective chart review was performed in Stony Brook (SB) Medicine hospitals, SB University Hospital (the only tertiary medical center in Suffolk County) and Southampton Hospital (a major hospital in the east end of Suffolk County). Laboratory records were queried for a positive B. miyamotoi PCR test from blood or a positive IgG antibody with a B. miyamotoi-specific EIA that utilizes a recombinant GlpQ antigen (both tests performed in a commercial laboratory). Results Twenty-eight cases were positive for serology (IgG EIA; n = 19) or PCR (n = 9). None of the IgG-positive cases had a positive PCR result indicating that individuals were likely exposed to B. miyamotoi in the past. Of the nine PCR-positive cases (median age:67 years), eight were men, three were diagnosed in the outpatient clinic (33.3%) and six were diagnosed through the emergency department and required hospitalization (66.6%). Thrombocytopenia and transaminitis were common findings. Two-thirds of these nine cases were diagnosed in the period of 2016–2017 and one-third in the period, 2013–2015 (P = 0.17). Conclusion An increasing number of cases of B. miyamotoi were observed in Suffolk County during 2013–2017 and two-thirds required hospitalization. The real burden of this tick borne disease in Suffolk County and the rest of the state is unknown. Disclosures All authors: No reported disclosures.

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Sharma, Rahul K., Maeher R. Grewal, Sallie M. Long, Brendon DiDonna, Joshua Sturm, Susannah E. Hills e Scott H. Troob. "Tracheostomy Outcomes in Patients With COVID-19 at a New York City Hospital". OTO Open 6, n. 2 (aprile 2022): 2473974X2211010. http://dx.doi.org/10.1177/2473974x221101025.

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Objective Tracheostomies have been performed in patients with prolonged intubation due to COVID-19. Understanding outcomes in different populations is crucial to tackle future epidemics. Study Design Prospective cohort study. Setting Tertiary academic medical center in New York City. Methods A prospectively collected database of patients with COVID-19 undergoing open tracheostomy between March 2020 and April 2020 was reviewed. Primary endpoints were weaning from the ventilator and from sedation and time to decannulation. Results Sixty-six patients underwent tracheostomy. There were 42 males (64%) with an average age of 62 years (range, 23-91). Patients were intubated for a median time of 26 days prior to tracheostomy (interquartile range [IQR], 23-30). The median time to weaning from ventilatory support after tracheostomy was 18 days (IQR, 10-29). Of those sedated at the time of tracheostomy, the median time to discontinuation of sedation was 5 days (IQR, 3-9). Of patients who survived, 39 (69%) were decannulated. Of those decannulated before discharge (n = 39), the median time to decannulation was 36 days (IQR, 27-49) following tracheostomy. The median time from ventilator liberation to decannulation was 14 days (IQR, 8-22). Thirteen patients (20.0%) had minor bleeding requiring packing. Two patients (3%) had bleeding requiring neck exploration. The all-cause mortality rate was 10.6%. No patients died of procedural causes, and no surgeons acquired COVID-19. Conclusion Open tracheostomies were successfully and safely performed at our institution in the peak of the COVID-19 pandemic. The majority of patients were successfully weaned from the ventilator and sedation. Approximately 60% of patients were decannulated prior to hospital discharge.

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Comer, James A., William L. Nicholson, James G. Olson e James E. Childs. "Serologic Testing for Human Granulocytic Ehrlichiosis at a National Referral Center". Journal of Clinical Microbiology 37, n. 3 (1999): 558–64. http://dx.doi.org/10.1128/jcm.37.3.558-564.1999.

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An indirect immunofluorescence assay (IFA) was used to identify patients with antibodies reactive to the human granulocytic ehrlichiosis (HGE) agent. Serum samples collected from clinically ill individuals were submitted to the Centers for Disease Control and Prevention by physicians via state health departments from throughout the United States and tested against a panel of ehrlichial and rickettsial pathogens. Antibodies reactive to the HGE agent were detected in 142 (8.9%) of 1,602 individuals tested. There were 19 confirmed and 59 probable (n = 78) cases of HGE as defined by seroconversion or a fourfold or higher titer to the HGE agent than to the Ehrlichia chaffeensis antigens. The average age of patients with HGE was 57 years, and males accounted for 53 (68%) of the patients. Cases of HGE occurred in 21 states; 47 (60%) of the cases occurred in Connecticut (n = 14), New York (n = 18), and Wisconsin (n = 15). Onset of HGE was identified from April through December, with cases peaking in June and July. The earliest confirmed cases of HGE occurred in 1987 in Wisconsin and 1988 in Florida. No fatalities were reported among the 78 patients with confirmed or probable HGE. Reactivity to the HGE agent and to either Coxiella burnetii, Rickettsia rickettsii, or Rickettsia typhi was infrequent; however, 74 (52%) of the 142 individuals who were positive for HGE had at least one serum sample that also reacted to the E. chaffeensis antigen. Thirty-four persons with confirmed or probable human monocytic ehrlichiosis due to E. chaffeensis also had antibodies to the HGE agent in at least one serum sample. The specific etiologic agent for 30 patients was not ascribed because of similarity of titers to both ehrlichial antigens. The use of both antigens may be required to correctly diagnose most cases of human ehrlichiosis, especially in geographic regions where both the HGE agent and E. chaffeensis occur.

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ZHURILO, D. Yu, M. V. GUTNYK e A. G. ZHURILO. "George de Bothezat and his contribution into the world aviation and astronautics". Kosmìčna nauka ì tehnologìâ 28, n. 1 (28 febbraio 2022): 70–80. http://dx.doi.org/10.15407/knit2022.01.070.

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The article dedicated the life and scientific way of George de Bothezat, the first Doctor of Sciences in the field of aviation. Together with Nikolay Zhukovsky, Igor Sikorsky, Stephen Timoshenko, Alexander Fan-der-Flit, and Alexey Lebedev, he was one of the organizers of the Air Fleet of the Russian Empire. He is the author of various inventions: gyroscopic sight and other types of aviation equipment. We analyze works by G. Bothezat on the impulse theory of propellers. In particular, the scientist derived formulas for ensuring the flight stability of airplanes and helicopters. He developed training ballistic tables, which allowed making corrections for the speed of the flight and the direction of the wind. We briefly describe a biography of G. Bothezat, focusing on the student period of his life in Kharkiv, Ukraine, and the reasons for G. Bothezat’s departure to the United States in 1918. It is stated that it was there that his talent as a designer and creator of helicopters of the original system was disclosed in the best way. In 1922, George Bothezat obtained the financial support of the American government to build a workable helicopter model without prototypes and experiments, only based on the results of calculations. The reasons why G.Bothezat did not manage to achieve the launch of the serial production of helicopters are analyzed. We also mention the activities of the company founded by G.Bothezat, which was engaged in the production of fans of a new type for the US Navy. The Bothezat system fans were installed at the Rockefeller Center in New York as well as in American tanks. It is emphasized that I. Sikorsky also used the works by G.Bothezat in his research. It is stated that the flight trajectory calculated by G.Bothezat in air and airless space was used in the development of the American program of a manned landing on the Moon using the “Apollo” system.

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Ris, Ethan W. "The Origins of Systemic Reform in American Higher Education, 1895–1920". Teachers College Record: The Voice of Scholarship in Education 120, n. 10 (ottobre 2018): 1–42. http://dx.doi.org/10.1177/016146811812001007.

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Background/Context The traditional literature on the history of higher education in the United States focuses on linear explanations of the inexorable growth of the size, mission, and importance of colleges and universities. That approach ignores or minimizes a recurrent strain of discontent with the higher education sector, especially from policy elites. Purpose/Objective/Research Question/Focus of Study This article examines the century-old origins of a continuing reform impulse in higher education. It identifies the reforms in question as “systemic,” both because they extended beyond the workings of individual colleges and universities and because they had at their heart the dream of systemization, linking and coordinating policy at groupings of institutions at the state, regional, or national level. The narrative focuses on the establishment, operations, and ideology of two early philanthropic foundations designed to spur systemic reform in the higher education sector: the Carnegie Foundation for the Advancement of Teaching and the General Education Board. Research Design This article relies on historical analysis informed by organizational theory. Data Collection and Analysis The data for this article come from new archival research, mostly conducted at the Rockefeller Archive Center (Sleepy Hollow, NY), Library of Congress Manuscript Division (Washington, DC), and Columbia University Rare Book and Manuscript Library (New York, NY). Conclusions/Recommendations This article identifies an ideologically consistent, interlocked cohort of reformers whom the author calls “the academic engineers.” These individuals, associated with elite universities and philanthropic foundations, articulated a vision of higher education reform based on increasing the efficiency and utility of institutions and linking them together in a hierarchical system. The author identifies four key features of this vision and describes the academic engineers’ efforts to enact them. The reformers had some successes but failed to realize their overarching goals; in the article's conclusion, the author examines the historical context and organizational theory as partial explanations for this shortfall.

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Brackbill, Robert M., Amy R. Kahn, Jiehui Li, Rachel Zeig-Owens, David G. Goldfarb, Molly Skerker, Mark R. Farfel et al. "Combining Three Cohorts of World Trade Center Rescue/Recovery Workers for Assessing Cancer Incidence and Mortality". International Journal of Environmental Research and Public Health 18, n. 4 (3 febbraio 2021): 1386. http://dx.doi.org/10.3390/ijerph18041386.

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Three cohorts including the Fire Department of the City of New York (FDNY), the World Trade Center Health Registry (WTCHR), and the General Responder Cohort (GRC), each funded by the World Trade Center Health Program have reported associations between WTC-exposures and cancer. Results have generally been consistent with effect estimates for excess incidence for all cancers ranging from 6 to 14% above background rates. Pooling would increase sample size and de-duplicate cases between the cohorts. However, pooling required time consuming steps: obtaining Institutional Review Board (IRB) approvals and legal agreements from entities involved; establishing an honest broker for managing the data; de-duplicating the pooled cohort files; applying to State Cancer Registries (SCRs) for matched cancer cases; and finalizing analysis data files. Obtaining SCR data use agreements ranged from 6.5 to 114.5 weeks with six states requiring >20 weeks. Records from FDNY (n = 16,221), WTCHR (n = 29,372), and GRC (n = 33,427) were combined de-duplicated resulting in 69,102 unique individuals. Overall, 7894 cancer tumors were matched to the pooled cohort, increasing the number cancers by as much as 58% compared to previous analyses. Pooling resulted in a coherent resource for future research for studies on rare cancers and mortality, with more representative of occupations and WTC- exposure.

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Thomas, Sumi, Yaser Hussein, Sudeshna Bandyopadhyay, Michele Cote, Oudai Hassan, Eman Abdulfatah, Baraa Alosh, Hui Guan, Robert A. Soslow e Rouba Ali-Fehmi. "Interobserver Variability in the Diagnosis of Uterine High-Grade Endometrioid Carcinoma". Archives of Pathology & Laboratory Medicine 140, n. 8 (3 maggio 2016): 836–43. http://dx.doi.org/10.5858/arpa.2015-0220-oa.

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Context.—Low interobserver diagnostic agreement exists among high-grade endometrial carcinomas. Objective.—To evaluate diagnostic variability in International Federation of Gynecology and Obstetrics (FIGO) grade 3 endometrioid adenocarcinoma (G3EC) in 2 different sign-out practices. Design.—Sixty-six G3EC cases were identified from pathology archives of Wayne State University (WSU, Detroit, Michigan) (general surgical pathology sign-out) and 65 from Memorial Sloan Kettering Cancer Center (MSK, New York, New York) (gynecologic pathology focused sign-out). Each case was reviewed together by 2 gynecologic pathologists, one from each institution, and classified into the G3EC group or a reclassified group. Clinicopathologic parameters were compared. Results.—Twenty-five WSU cases (38%) were reclassified as undifferentiated (n = 2), serous (n = 4), mixed endometrioid and serous carcinomas (n = 12), and FIGO grade 2 endometrioid adenocarcinomas with focal marked nuclear atypia (n = 7). Eleven MSK cases (17%) were reclassified as undifferentiated (n = 5), serous (n = 1), mixed endometrioid and serous carcinomas (n = 4), and mixed endometrioid and clear cell carcinomas (n = 1). Agreement rate between original and review diagnosis was 83% (54 of 65) at MSK and 62% (41 of 66) at WSU (P = .01) with an overall rate of 73% (95 of 131). There were more undifferentiated carcinomas at MSK than there were at WSU (45% [5 of 11] versus 8% [2 of 25]; P = .02). There were more grade 2 endometrioid adenocarcinomas with focal, marked nuclear atypia at WSU (28%; 7 of 25) than there were at MSK (0%) (P = .03). Mixed endometrioid and serous carcinoma was the most common misclassified subtype (44%; 16 of 36). Conclusion.—Moderate interobserver variability exists in the diagnosis of G3EC with a significantly greater diagnostic agreement rate in gynecologic pathology–focused sign-out than in general sign-out practice.

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Fein, Joshua Alexander, Agnes McAuliffe, Kimberly Fischer, Owen Brady, Sean M. Devlin, Silvia Willumsen, Gonca Ozcan et al. "Impact of a shared-care model between community and academic centers for facilitating access to allogeneic and autologous stem cell transplantation." Journal of Clinical Oncology 40, n. 16_suppl (1 giugno 2022): 1510. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.1510.

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1510 Background: Despite curative or disease-controlling roles in AML/MDS and MM, access to allogeneic (allo) and autologous (auto) hematopoietic stem cell transplantation (SCT) remains far from universal. Socioeconomic status (SES) and geographic distance from SCT centers have been shown to be barriers to SCT access. In 2016, Hartford HealthCare (HHC) and the Memorial Sloan Kettering Cancer Center (MSK) pioneered a Shared-Care Model (SCM) to streamline access to allo and auto SCT at MSK, featuring a dedicated nurse SCT coordinator, shared hematology tumor boards, MSK-led didactics for HHC providers, and an electronic health record sharing pipeline. We sought to determine if this has improved access to SCT for HHC patients. Methods: A retrospective chart review was conducted of HHC patients aged 18-70 with new diagnoses of AML, MDS, and MM between 2016 and 2020. Socioeconomic status (SES) was estimated by 9-digit zip-code using the Area Deprivation Index (ADI), shown to be a surrogate for healthcare access. Referral or not to a SCT center, referral to MSK through the SCM, and reasons for non-referral were abstracted from the medical record. For patients referred for SCT at MSK, we also captured the number of peri-SCT days in New York City (NYC) and number of subsequent MSK and HHC clinic visits/hospitalizations within 1-year post-SCT. Results: A total of 126 patients was included, with 81 (64%) treated for AML/MDS and 45 (36%) for MM. The median age was 60 years (interquartile range [IQR]: 53-66). The majority were white (n = 101, 80%) followed by 10% (n = 13) Black/African American; 10% (n = 12) were of Hispanic ethnicity. The median ADI percentile was 38 (IQR: 20-51; higher percentiles reflect decreased SES). The median ADI for MSK SCT referrals from New York, New Jersey, and Connecticut 2016-2020 for the same indications was 19 (IQR: 10-30, p < 0.001). A total of 90 patients (71%) were referred to SCT centers. Leading reasons for no referral were favorable-risk disease (n = 10), goals of care (n = 9), and death prior to referral (n = 5); 3 patients were not referred due to comorbidities/performance status. No differences were found between patients referred to MSK vs. other centers. Thirty-four HHC patients were referred to MSK (21 AML/MDS, 13 MM), vs. 3 between 2010 and 2015. Twelve patients underwent allo SCT, with median 97 days in NYC (range: 68-247); 8 underwent auto SCT, with median 21 days in NYC (range: 15-48). Conclusions: Our findings show the feasibility of a shared-care model between a non-SCT-providing large regional hospital system and a major academic transplantation center. Close collaboration between institutions may minimize time patients spend away from home. The SES of HHC referrals was lower than the general MSK population, suggesting that a shared-care model may facilitate access to SCT for patients with previous barriers for this potentially curative therapy.

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Fein, Joshua Alexander, Agnes McAuliffe, Kimberly Fischer, Owen Brady, Sean M. Devlin, Silvia Willumsen, Gonca Ozcan et al. "Impact of a shared-care model between community and academic centers for facilitating access to allogeneic and autologous stem cell transplantation." Journal of Clinical Oncology 40, n. 16_suppl (1 giugno 2022): 1510. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.1510.

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1510 Background: Despite curative or disease-controlling roles in AML/MDS and MM, access to allogeneic (allo) and autologous (auto) hematopoietic stem cell transplantation (SCT) remains far from universal. Socioeconomic status (SES) and geographic distance from SCT centers have been shown to be barriers to SCT access. In 2016, Hartford HealthCare (HHC) and the Memorial Sloan Kettering Cancer Center (MSK) pioneered a Shared-Care Model (SCM) to streamline access to allo and auto SCT at MSK, featuring a dedicated nurse SCT coordinator, shared hematology tumor boards, MSK-led didactics for HHC providers, and an electronic health record sharing pipeline. We sought to determine if this has improved access to SCT for HHC patients. Methods: A retrospective chart review was conducted of HHC patients aged 18-70 with new diagnoses of AML, MDS, and MM between 2016 and 2020. Socioeconomic status (SES) was estimated by 9-digit zip-code using the Area Deprivation Index (ADI), shown to be a surrogate for healthcare access. Referral or not to a SCT center, referral to MSK through the SCM, and reasons for non-referral were abstracted from the medical record. For patients referred for SCT at MSK, we also captured the number of peri-SCT days in New York City (NYC) and number of subsequent MSK and HHC clinic visits/hospitalizations within 1-year post-SCT. Results: A total of 126 patients was included, with 81 (64%) treated for AML/MDS and 45 (36%) for MM. The median age was 60 years (interquartile range [IQR]: 53-66). The majority were white (n = 101, 80%) followed by 10% (n = 13) Black/African American; 10% (n = 12) were of Hispanic ethnicity. The median ADI percentile was 38 (IQR: 20-51; higher percentiles reflect decreased SES). The median ADI for MSK SCT referrals from New York, New Jersey, and Connecticut 2016-2020 for the same indications was 19 (IQR: 10-30, p < 0.001). A total of 90 patients (71%) were referred to SCT centers. Leading reasons for no referral were favorable-risk disease (n = 10), goals of care (n = 9), and death prior to referral (n = 5); 3 patients were not referred due to comorbidities/performance status. No differences were found between patients referred to MSK vs. other centers. Thirty-four HHC patients were referred to MSK (21 AML/MDS, 13 MM), vs. 3 between 2010 and 2015. Twelve patients underwent allo SCT, with median 97 days in NYC (range: 68-247); 8 underwent auto SCT, with median 21 days in NYC (range: 15-48). Conclusions: Our findings show the feasibility of a shared-care model between a non-SCT-providing large regional hospital system and a major academic transplantation center. Close collaboration between institutions may minimize time patients spend away from home. The SES of HHC referrals was lower than the general MSK population, suggesting that a shared-care model may facilitate access to SCT for patients with previous barriers for this potentially curative therapy.

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Garg, N., G. Husk, T. Nguyen, A. Onyile, S. Echezona, G. Kuperman e J. S. Shapiro. "Hospital Closure and Insights into Patient Dispersion". Applied Clinical Informatics 06, n. 01 (2015): 185–99. http://dx.doi.org/10.4338/aci-2014-10-ra-0090.

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SummaryBackground: Hospital closures are becoming increasingly common in the United States. Patients who received care at the closing hospitals must travel to different, often farther hospitals for care, and nearby remaining hospitals may have difficulty coping with a sudden influx of patients.Objectives: Our objectives are to analyze the dispersion patterns of patients from a closing hospital and to correlate that with distance from the closing hospital for three specific visit types: emergency, inpatient, and ambulatory.Methods: In this study, we used data from a health information exchange to track patients from Saint Vincent’s Medical Center, a hospital in New York City that closed in 2010, to determine where they received emergency, inpatient, and ambulatory care following the closure.Results: We found that patients went to the next nearest hospital for their emergency and inpatient care, but ambulatory encounters did not correlate with distance.Discussion: It is likely that patients followed their ambulatory providers as they transitioned to another hospital system. Additional work should be done to determine predictors of impact on nearby hospitals when another hospital in the community closes in order to better prepare for patient dispersion.Citation: Garg N, Husk G, Nguyen T, Onyile A, Echezona S, Kuperman G, Shapiro JS. Hospital closure and insights into patient dispersion: the closure of Saint Vincent’s Catholic Medical Center in New York City. Appl Clin Inf 2015; 6: 185–199http://dx.doi.org/10.4338/ACI-2014-10-RA-0090

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Kormanik, Natasha L., Mitchell Chan, Jessica Boehmer, Tamy Kim, Gideon Michael Blumenthal e Richard Pazdur. "Project facilitate: A review of the FDA oncology center of excellence expanded access pilot program." Journal of Clinical Oncology 38, n. 15_suppl (20 maggio 2020): 7023. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.7023.

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7023 Background: Expanded Access (EA), also known as “compassionate use,” is a regulatory pathway in which a patient with an immediate life-threatening condition or disease can gain access to an investigational product for treatment when no satisfactory therapy is available. Oncology practices may lack the regulatory experience or administrative support to use EA. In response, FDA OCE launched Project Facilitate (PF), a call center to assist oncology healthcare providers requesting EA. An analysis of single-patient investigational new drugs (IND) was performed to assess the first 10 months of PF compared to the period prior to its launch. Methods: Preliminary data was extracted from the FDA’s central database that yielded 719 single-patient INDs between May 31-November 30, 2018 & 2019 in the Office of Oncologic Diseases (OOD). Data collected included IND receipt date, acknowledgment date, application status, drug name, underlying malignancy of patient, address of requesting physician, withdrawal date, and patient demographics. A manual review of INDs was performed to assess for actual processing dates and to capture demographics not captured by the database. A total of 28 INDs were excluded due to duplications, cancellation by Sponsor prior to issuance of FDA decision, or coding errors in the database. Industry denial explanations were reported by the provider by emails. Results: Data from 692 INDs were analyzed and 692 (100%) were granted safe to proceed. The median processing time was 1 day (mean=2) in 2018 and 1 day (mean= 1.5) in 2019. Our findings indicate that the volume of oncology EA requests increased by 76 (19%) in 2019 vs 2018. A total of 207 unique drugs were requested. Malignancies most frequently involved included: Acute myeloid leukemia (n = 84, 8.3%), soft tissue sarcoma (n = 77, 7.6%), and non-small cell lung cancer (n = 60, 5.9%). States with the highest requests included: California (n = 82, 11.8%), New York (n = 81, 11.7%), and Massachusetts (n = 42, 6.1%). A majority of requests were from major academic centers (77%). All denied requests (N = 9) by industry were due to company’s decision to not provide products outside of a clinical trial. Conclusions: The positive trends in decreased processing times and increased number of requests are consistent with OCE’s mission to improve efficiency of the EA program and ensure equitable access to all oncology patients. [Table: see text]

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Singh, Om, L. Venkateswara Rao, Amitabh Gaur, Niyam C. Sharma, Anis Alam e Gursaran P. Talwar. "Antibody response and characteristics of antibodies in women immunized with three contraceptive vaccines inducing antibodies against human chorionic gonadotropin**This study was conducted in five institutions with the clinical collaboration of the following physicians: Alok K. Banerjee M.D., National Institute of Health & Family Welfare, New Delhi; Kamala Dhall, M.D., Post Graduate Institute of Medical Education and Research, Chandigarh; Vera Hingorani, M.D., All India Institute of Medical Sciences, New Delhi; Usha R. Krishna, M.D., Seth G. S. Medical College & K.E.M. Hospital, Bombay; Shanti M. Shahani, M.D., T. N. Medical College & Nair Hospital, Bombay; and Badri N. Saxena, M.D., Indian Council of Medical Research, New Delhi.††Supported by grants from the S & T Mission Project of the Department of Biotechnology, Government of India, the International Development Research Centre of Canada and the Rockefeller Foundation, and benefited from cooperative interaction with the International Committee for Contraception Research of the Population Council, New York." Fertility and Sterility 52, n. 5 (novembre 1989): 739–44. http://dx.doi.org/10.1016/s0015-0282(16)61024-5.

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Colbeth, Hilary L., Rachel Zeig-Owens, Mayris P. Webber, David G. Goldfarb, Theresa M. Schwartz, Charles B. Hall e David J. Prezant. "Post-9/11 Peripheral Neuropathy Symptoms among World Trade Center-Exposed Firefighters and Emergency Medical Service Workers". International Journal of Environmental Research and Public Health 16, n. 10 (16 maggio 2019): 1727. http://dx.doi.org/10.3390/ijerph16101727.

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Peripheral neuropathy can result from numerous conditions including metabolic disorders, inflammatory disease, or exposure to environmental or biological toxins. We analyzed questionnaire data from 9239 Fire Department of the City of New York (FDNY) World Trade Center (WTC)-exposed firefighters and emergency medical service workers (EMS) to evaluate the association between work at the WTC site and subsequent peripheral neuropathy symptoms using the validated Diabetic Neuropathy Symptom (DNS) score. We grouped the population into an “Indicated” group with conditions known to be associated with paresthesia (N = 2059) and a “Non-Indicated” group without conditions known to be associated (N = 7180). The level of WTC exposure was categorized by time of arrival to the WTC. Overall, 25% of workers aged 40 and older reported peripheral neuropathy symptoms: 30.6% in the Indicated and 23.8% in the Non-Indicated groups, respectively. Multivariable logistic models performed on the Non-Indicated group, and on the Non-Indicated in comparison with non-WTC exposed National Health and Nutrition Examination Survey (NHANES), found that the highest level of WTC-exposure was significantly associated with DNS positive outcomes, after controlling for potential confounders. In conclusion, this study suggests that symptoms of peripheral neuropathy and paresthesias are common and are associated with WTC-exposure intensity.

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De Souza, Monique, Raghuwinder Singh, Nathan E. Harms, John McPhedran e Alicyn N. Smart. "First Report of Leaf Spot Caused by Septoria villarsiae on Nymphoides peltata in the United States". Plant Health Progress 22, n. 2 (1 gennaio 2021): 157–58. http://dx.doi.org/10.1094/php-12-20-0104-br.

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Nymphoides peltata, commonly known as yellow floating heart, is a freshwater aquatic plant with floating leaves. It is a highly invasive aquatic weed that has been introduced into several countries, including Ireland, New Zealand, Sweden, and the United States. In September 2019, N. peltata plants exhibiting leaf spots were collected from a private pond near Buxton, York County, Maine. Leaf spots were present on a majority of plants, and pycnidia were observed in the center of the spots. Individual pycnidia were aseptically transferred to 1/4-strength potato dextrose agar. Dark gray to black slow-growing colonies were observed between 7 and 14 days. Based on the morphological characteristics, the fungus was identified as Septoria sp. Translation elongation factor 1-alpha gene was amplified, and a 570-bp sequence resulted in 100 and 99.74% homology with Septoria villarsiae strains CBS565.88 and CBS514.78 isolated from N. peltata in the Netherlands, respectively. Previously, S. villarsiae has been reported on Limnanthemum nymphoides from India and on N. peltata from Korea, Poland, Romania, and the Netherlands. To our knowledge, this is the first report of leaf spot caused by S. villarsiae on N. peltata in the United States.

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Maull, Deirdre J., Barry H. Grayson, Court B. Cutting, Larry L. Brecht, Fred L. Bookstein, Deljou Khorrambadi, Jon A. Webb e Dennis J. Hurwitz. "Long-Term Effects of Nasoalveolar Molding on Three-Dimensional Nasal Shape in Unilateral Clefts". Cleft Palate-Craniofacial Journal 36, n. 5 (settembre 1999): 391–97. http://dx.doi.org/10.1597/1545-1569_1999_036_0391_lteonm_2.3.co_2.

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Objective: This objective of this study was to determine the effect of presurgical nasoalveolar molding on long-term nasal shape in complete unilateral clefts. Design: The study was retrospective, and the subjects were chosen at random. Nasal casts of the subjects were scanned in three dimensions. Each nose was best fit to its mirror image, and a numerical asymmetry score was determined. Setting: All patients were treated at the Institute of Reconstructive Plastic Surgery, NYU Medical Center, New York, New York. Patients: The study subjects (n = 10) were selected from a group that had undergone presurgical nasal molding in conjunction with alveolar molding. The control subjects (n = 10) were selected from a group that had undergone presurgical alveolar molding alone. Interventions: All subjects underwent presurgical orthopedic treatment until the age of approximately 4 months at which time the primary surgery was performed. Main Outcome Measure: The nasal shape following nasal molding should be more symmetrical than if molding had not been done. Results: The mean asymmetry index for the nasoalveolar molding group was 0.74, and the control group was 1.21. This difference was statistically significant (p < .05). Conclusions: Presurgical nasoalveolar molding significantly increases the symmetry of the nose. The increase in symmetry is maintained long term into early childhood. The limitations of this study include (1) asymmetry alone is not an adequate shape result in most situations, (2) the children evaluated in this study were not fully grown, and (3) the control group was not age matched.

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Berger, Kenneth I., Meredith Turetz, Mengling Liu, Yongzhao Shao, Angeliki Kazeros, Sam Parsia, Caralee Caplan-Shaw et al. "Oscillometry complements spirometry in evaluation of subjects following toxic inhalation". ERJ Open Research 1, n. 2 (ottobre 2015): 00043–2015. http://dx.doi.org/10.1183/23120541.00043-2015.

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The World Trade Center (WTC) destruction released dust and fumes into the environment. Although many community members developed respiratory symptoms, screening spirometry was usually normal. We hypothesised that forced oscillation testing would identify functional abnormalities undetected by spirometry and that symptom severity would relate to magnitude of abnormalities measured by oscillometry.A symptomatic cohort (n=848) from the Bellevue Hospital WTC Environmental Health Center was evaluated and compared to an asymptomatic cohort (n=475) from the New York City Department of Health WTC Health Registry. Spirometry and oscillometry were performed. Oscillometry measurements included resistance (R5) and frequency dependence of resistance (R5−20).Spirometry was normal for the majority of subjects (73.2% symptomatic versus 87.6% asymptomatic, p<0.0001). In subjects with normal spirometry, R5 and R5−20 were higher in symptomatic versus asymptomatic subjects (median (interquartile range) R5 0.436 (0.206) versus 0.314 (0.129) kPa·L−1·s−1, p<0.001; R5−20 0.075 (0.085) versus 0.004 (0.042) kPa·L−1·s−1, p<0.0001). In symptomatic subjects, R5 and R5−20 increased with increasing severity and frequency of wheeze (p<0.05).Measurement of R5–20 correlated with the presence and severity of symptoms even when spirometry was within normal limits. These findings are in accord with small airway abnormalities as a potential explanation of the respiratory symptoms.

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Mgbako, Ofole, Monica Mehta, Donald Dietz, Matthew J. Neidell, Simian (Esther) Huang, Jason Zucker, Sherif Shoucri, Christine J. Kubin e Delivette Castor. "Race and Remdesivir: Examination of Clinical Outcomes in a Racially and Ethnically Diverse Cohort in New York City". Ethnicity and Disease 33, n. 1 (1 gennaio 2023): 1–8. http://dx.doi.org/10.18865/1653.

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Objective To compare clinical characteristics and examine in-hospital length of stay (LOS) differences for COVID-19 patients who received remdesivir, by race or ethnicity. Design Retrospective descriptive analysis comparing cumulative LOS as a proxy of recovery time. Setting A large academic medical center serving a minoritized community in Northern Manhattan, New York City. Participants Inpatients (N=1024) who received remdesivir from March 30, 2020–April 20, 2021. Methods We conducted descriptive analyses among patients who received remdesivir. Patients were described by proxies of social determinants of health (SDOH): race and ethnicity, residence, insurance coverage, and clinical characteristics. We calculated median hospital LOS as the cumulative incidence of hospitalized patients who were discharged alive, and tested differences between groups by using the Gray test. Patients who died or were discharged to hospice were censored at 29 days. Main Outcome Measures The primary outcome was hospital LOS. The secondary outcome was in-hospital mortality. Results Median LOS was 11.9 days (95% CI, 10.8-13.2) overall, with Black patients having the shortest (10.0 days, 95% CI, 8.0-13.2) and Asian patients having the longest (16.2 days, 95% CI, 8.3-27.2) LOS. A total of 214 patients (21%) died or were discharged to hospice, ranging from 16.5% to 23.7% of patients who identified as Black and Other (multiracial, biracial, declined), respectively. Conclusions COVID-19 has disproportionately burdened communities of color. We observed no difference in median LOS between racial or ethnic groups, which supports the notion that the heterogeneous effect of remdesivir in the literature may be explained in part by underrecruitment or participation of Black, Hispanic, and Asian patients in clinical trials.

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Lambert, Ben, Isaac J. Stopard, Amir Momeni-Boroujeni, Rachelle Mendoza e Alejandro Zuretti. "Using patient biomarker time series to determine mortality risk in hospitalised COVID-19 patients: A comparative analysis across two New York hospitals". PLOS ONE 17, n. 8 (18 agosto 2022): e0272442. http://dx.doi.org/10.1371/journal.pone.0272442.

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A large range of prognostic models for determining the risk of COVID-19 patient mortality exist, but these typically restrict the set of biomarkers considered to measurements available at patient admission. Additionally, many of these models are trained and tested on patient cohorts from a single hospital, raising questions about the generalisability of results. We used a Bayesian Markov model to analyse time series data of biomarker measurements taken throughout the duration of a COVID-19 patient’s hospitalisation for n = 1540 patients from two hospitals in New York: State University of New York (SUNY) Downstate Health Sciences University and Maimonides Medical Center. Our main focus was to quantify the mortality risk associated with both static (e.g. demographic and patient history variables) and dynamic factors (e.g. changes in biomarkers) throughout hospitalisation, by so doing, to explain the observed patterns of mortality. By using our model to make predictions across the hospitals, we assessed how predictive factors generalised between the two cohorts. The individual dynamics of the measurements and their associated mortality risk were remarkably consistent across the hospitals. The model accuracy in predicting patient outcome (death or discharge) was 72.3% (predicting SUNY; posterior median accuracy) and 71.3% (predicting Maimonides) respectively. Model sensitivity was higher for detecting patients who would go on to be discharged (78.7%) versus those who died (61.8%). Our results indicate the utility of including dynamic clinical measurements when assessing patient mortality risk but also highlight the difficulty of identifying high risk patients.

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Waters, Michele, Greg Crewse, Cole Manship, Abigail Baldwin-Medsker, Chris Fong, Nikolaus Schultz, Sergio Giralt et al. "Abstract 1009: Direct partnering with employers and unions diversifies cancer center access". Cancer Research 84, n. 6_Supplement (22 marzo 2024): 1009. http://dx.doi.org/10.1158/1538-7445.am2024-1009.

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Abstract Treatment at academic cancer centers can further research and improve patient outcomes. Interventions improving access to treatment across racial, ethnic, and socioeconomic boundaries might increase the generalizability of studies conducted at such centers and reduce healthcare inequities. Memorial Sloan Kettering (MSK) is an academic cancer center based in New York and New Jersey (NY/NJ). Like many other NCI-designated cancer centers, it has historically served a population within its geographic catchment, with limited diversity. MSK Direct is a national cancer benefits program that partners with employers and unions to provide a direct referral service for their employees or members and their families, including in-person care and remote second opinions outside NY/NJ. Whether such programs diversify access to academic cancer care is understudied. To evaluate whether the service diversifies access to academic cancer care, we examined the self-identified race and ethnicity, geographic composition, and imputed socioeconomic status (Yost Index) of MSK Direct and non-MSK Direct (Control) patients with at least one assessment note at MSK since program inception in 2016 until September 21, 2023. We further stratified MSK Direct patients based on referral by employers vs. unions. Groups were compared using Chi-square or Student T tests. The MSK Direct patient population (N=8,604) was more racially diverse than the Control population (N=283,434), with 9.0% Black/African American patients compared to 6.9% Control (p<0.001) patients and 9.3% Asian-Far East/Indian Subcontinental patients compared to 7.5% Control patients (p<0.001). Of MSK Direct patients, 10.5% identified as Hispanic or Latino vs. 7.5% of Control patients (p<0.001). Among MSK Direct patients, 14.2% of union-member patients self-identified as Black vs. 6.1% of non-union members, while Asian patients comprised 12.1% of company-referral patients vs. 5.8% of union patients. Hispanic patients represented 17.4% of union-referral patients vs. 6.5% of company referrals. The median Yost Index of union MSK Direct patients was 25 vs. 12 (non-union) and 17 (Control, p<0.001), signifying a less privileged socioeconomic status for union-referred patients. A total of N=336 MSK Direct patients received guidance through remote second opinions across 41 states, with the most common home states being Georgia, Arizona, and Florida. Addressing healthcare disparities in diverse populations is a complex and systemic challenge. Direct partnerships with employers and unions are a new paradigm that may expand access to academic cancer care outside a center’s usual geographic and sociodemographic catchment. Different partnering strategies may enhance the representation of specific patient populations. Citation Format: Michele Waters, Greg Crewse, Cole Manship, Abigail Baldwin-Medsker, Chris Fong, Nikolaus Schultz, Sergio Giralt, Benjamin Roman, Michelle Johnson, Francesca Gany, Carol Brown, Bob T. Li, Justin Jee. Direct partnering with employers and unions diversifies cancer center access [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 1009.

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Lynch, Thomas B., e Robert F. Wittwer. "n-Tree distance sampling for per-tree estimates with application to unequal-sized cluster sampling of increment core data". Canadian Journal of Forest Research 33, n. 7 (1 luglio 2003): 1189–95. http://dx.doi.org/10.1139/x03-036.

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Samples from the n trees nearest to a point or plot center are sometimes used to estimate per-tree values such as age or growth from increment cores. Clutter et al. (J.L. Clutter, J.C. Fortson, L.V. Pienaar, G.H. Brister, and R.L. Bailey. 1983. Timber management: a quantitative approach. John Wiley & Sons, New York) indicated that this procedure can be biased because it is more likely to sample large trees occupying large amounts of space. This sampling procedure falls into the category of n-tree distance sampling in which the nth closest tree to a point defines a plot radius that can be used to estimate number of trees or amount of volume per hectare. When a ratio of n-tree per-hectare estimates is used to estimate per-tree attributes, the resulting estimator is a weighted average in which weights are the inverse of the n-tree sampling plot size. Since this ratio estimator essentially weights observations inversely with plot size, it is not subject to the objections of Clutter et al. (1983). This estimator is used to estimate age by diameter at breast height class for eastern cottonwood (Populus deltoides Bartr. ex Marsh.) on the Cimarron National Grassland.

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Wagner, JE, J. Rosenthal, R. Sweetman, XO Shu, SM Davies, NK Ramsay, PB McGlave, L. Sender e MS Cairo. "Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease". Blood 88, n. 3 (1 agosto 1996): 795–802. http://dx.doi.org/10.1182/blood.v88.3.795.795.

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Abstract To reduce the morbidity and mortality associated with unrelated donor bone marrow (BM) transplantation and potentially extend the pool of suitable donors, cryopreserved unrelated donor umbilical cord blood was considered as an alternate source of hematopoietic stem cells for transplantation. Patients with leukemia, BM failure syndrome, or inborn error of metabolism were eligible for a phase I clinical trial designed to estimate the risk of graft failure and severe acute graft-versus- host disease after transplantation of umbilical cord blood from unrelated donors. As of December 21, 1995, unrelated donor umbilical cord blood was used to reconstitute hematopoiesis in eighteen patients aged 0.1 to 21.3 years weighing 3.3 to 78.8 kg with acquired or congenital lympho-hematopoietic disorders or metabolic disease. Patients received either HLA-matched (n = 7) or HLA-1 to 3 antigen disparate (n = 11) grafts collected and evaluated by the New York Blood Center (New York, NY). The probability of engraftment after unrelated donor umbilical cord blood transplantation was 100% with no patient having late graft failure to date. The probability of grade III-IV acute graft-versus-host disease at 100 days was 11%. With a median follow-up of 6 months (range, 1.6 to 17 months); the probability of survival at 6 months is 65% in this high risk patient population. We conclude that cryopreserved umbilical cord blood from HLA-matched and mismatched unrelated donors is a sufficient source of transplantable hematopoietic stem cells with high probability of donor derived engraftment and low risk of refractory severe acute graft-versus-host disease. Limitations with regard to recipient size and degree of donor HLA disparity remain to be determined.

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Wagner, JE, J. Rosenthal, R. Sweetman, XO Shu, SM Davies, NK Ramsay, PB McGlave, L. Sender e MS Cairo. "Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease". Blood 88, n. 3 (1 agosto 1996): 795–802. http://dx.doi.org/10.1182/blood.v88.3.795.bloodjournal883795.

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To reduce the morbidity and mortality associated with unrelated donor bone marrow (BM) transplantation and potentially extend the pool of suitable donors, cryopreserved unrelated donor umbilical cord blood was considered as an alternate source of hematopoietic stem cells for transplantation. Patients with leukemia, BM failure syndrome, or inborn error of metabolism were eligible for a phase I clinical trial designed to estimate the risk of graft failure and severe acute graft-versus- host disease after transplantation of umbilical cord blood from unrelated donors. As of December 21, 1995, unrelated donor umbilical cord blood was used to reconstitute hematopoiesis in eighteen patients aged 0.1 to 21.3 years weighing 3.3 to 78.8 kg with acquired or congenital lympho-hematopoietic disorders or metabolic disease. Patients received either HLA-matched (n = 7) or HLA-1 to 3 antigen disparate (n = 11) grafts collected and evaluated by the New York Blood Center (New York, NY). The probability of engraftment after unrelated donor umbilical cord blood transplantation was 100% with no patient having late graft failure to date. The probability of grade III-IV acute graft-versus-host disease at 100 days was 11%. With a median follow-up of 6 months (range, 1.6 to 17 months); the probability of survival at 6 months is 65% in this high risk patient population. We conclude that cryopreserved umbilical cord blood from HLA-matched and mismatched unrelated donors is a sufficient source of transplantable hematopoietic stem cells with high probability of donor derived engraftment and low risk of refractory severe acute graft-versus-host disease. Limitations with regard to recipient size and degree of donor HLA disparity remain to be determined.

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47

Renaud, Jean, e Gustave Goldmann. "Les répercussions du 11 septembre 2001 sur l’établissement économique des nouveaux immigrants au Canada et au Québec". Recherche 46, n. 2 (1 febbraio 2006): 281–99. http://dx.doi.org/10.7202/012175ar.

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Quelles répercussions les événements qui se sont produits au World Trade Center de New York le 11 septembre 2001 ont-ils eues sur l’établissement en emploi des nouveaux immigrants au Canada ? Alors qu’on se serait attendu à une incidence différenciée selon l’origine ethnique, défavorable aux personnes d’origine arabe à cause de la stigmatisation de ce groupe par l’opinion publique, l’analyse ne révèle pas de tels effets. On se retrouve plutôt face à un ralentissement du marché de l’emploi à son resserrement pour les immigrants les plus jeunes et les plus vieux, ralentissement qui se présente de façon différente au Québec et dans le reste du Canada. Cette analyse est possible car la première vague d’entrevues de l’Enquête longitudinale auprès des immigrants du Canada (ELIC) de Statistique Canada était en cours en septembre 2001 (n = 12 040). Les analyses sont réalisées à l’aide de régressions de survie semi-paramétriques.

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48

Gomez, Jose L., Xiting Yan, Carole T. Holm, Nicole Grant, Qing Liu, Lauren Cohn, Vera Nezgovorova et al. "Characterisation of asthma subgroups associated with circulating YKL-40 levels". European Respiratory Journal 50, n. 4 (ottobre 2017): 1700800. http://dx.doi.org/10.1183/13993003.00800-2017.

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The chitinase-like protein YKL-40 mediates airway inflammation and serum levels are associated with asthma severity. However, asthma phenotypes associated with YKL-40 levels have not been precisely defined.We conducted an unsupervised cluster analysis of asthma patients treated at the Yale Center for Asthma and Airways Disease (n=156) to identify subgroups according to YKL-40 level. The resulting YKL-40 clusters were cross-validated in cohorts from the Severe Asthma Research Programme (n=167) and the New York University/Bellevue Asthma Repository (n=341). A sputum transcriptome analysis revealed molecular pathways associated with YKL-40 subgroups.Four YKL-40 clusters (C1–C4) were identified. C3 and C4 had high serum YKL-40 levels compared with C1 and C2. C3 was associated with earlier onset and longer duration of disease, severe airflow obstruction, and near-fatal asthma exacerbations. C4 had the highest serum YKL-40 levels, adult onset and less airflow obstruction, but frequent exacerbations. An airway transcriptome analysis in C3 and C4 showed activation of non-type 2 inflammatory pathways.Elevated serum YKL-40 levels were associated with two distinct clinical asthma phenotypes: one with irreversible airway obstruction and another with severe exacerbations. The YKL-40 clusters are potentially useful for identification of individuals with severe or exacerbation-prone asthma.

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49

Johnston, Robert H. "ImperialRussianForeignPolicvy Edited and translated by Hugh Ragsdale, assisted by V. N. Ponomarev. Cambridge and New York: Woodrow Wilson Center Press and Cambridge University Press, 1993. xv, 457 pp." Canadian-American Slavic Studies 30, n. 2-4 (1996): 299–300. http://dx.doi.org/10.1163/221023996x00402.

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50

Kouides, Peter A., Alice J. Cohen, Donna DiMichele, Mary Jane Petruzzi e Parvin Saidi. "The Variable Success of Managing Bleeding Disorder Related Menorrhagia: A Multicenter Study within the Hemophilia Treatment Center Network." Blood 104, n. 11 (16 novembre 2004): 3089. http://dx.doi.org/10.1182/blood.v104.11.3089.3089.

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Abstract The growing awareness to screen women with menorrhagia for an underlying bleeding disorder has led to an increase in enrollment of identified cases in Hemophilia Treatment Centers (HTCs). However, the outcome of menorrhagia management in these women has not been well-described. Objective : To determine the efficacy/outcome of the management of bleeding disorder-related menorrhagia in patients enrolled within the HTC network. Patients and Methods : Registry study of initial data collection of retrospective obstetrical and gynecological events with prospective yearly follow-up for 5 years for new obstetrical and gynecological events. Results : 99 women from five HTCs in New York-New Jersey Region II have been registered to date, mean age 38±16.3, median age 40. Diagnoses are: von Willebrand disease (VWD) in 71%; thrombocytopathy in 6%; factor deficiency in 23%. Menstrual status and outcomes presently: ⇒32/99 (32%) are not menstruating due to hysterectomy or post/peri-menopausal status; 13/99 have undergone a hysterectomy (n=10) or endometrial ablation (n=3) for menorrhagia control; in 7/10 of the women undergoing a hysterectomy for menorrhagia control, the diagnosis of VWD was previously established; 6/7of these women attempted medical treatment prior to hysterectomy ⇒68/99 (68%) are presently menstruating. Of those menstruating, menstrual status is as follows: Normal menses: 23.5% (16/68) Menorrhagia under control: 23.5% (16/68); of these patients; 11/16 have achieved control with oral contraceptive(OC), the remaining 5 patients have achieved control with intranasal DDAVP or Amicar Menorrhagia presently: 53% (36/68); 22/36 (61%) have undergone a course of ineffective menorrhagia treatment including intranasal DDAVP in 17/22 Conclusions : The majority of women with menorrhagia enrolled in HTCs have persistent menorrhagia despite evaluation and management within the HTC network. Only a small proportion have menorrhagia control due to intranasal DDAVP use and a proportion still necessitate hysterectomy for menorrhagia control. The value in United States HTCs of hemostatic measures alone such as intranasal DDAVP in the management of bleeding disorder related menorrhagia is uncertain at this time. Further study of combined therapy (intranasal DDAVP and Amicar ± OC) and novel approaches (levonorgestrel-intrauterine device) is warranted as are efforts to procure tranexamic acid for use in the U.S.

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