Letteratura scientifica selezionata sul tema "RNA-Targeted small molecules"
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Articoli di riviste sul tema "RNA-Targeted small molecules"
Costales, Matthew G., Haruo Aikawa, Yue Li, Jessica L. Childs-Disney, Daniel Abegg, Dominic G. Hoch, Sai Pradeep Velagapudi et al. "Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer". Proceedings of the National Academy of Sciences 117, n. 5 (21 gennaio 2020): 2406–11. http://dx.doi.org/10.1073/pnas.1914286117.
Testo completoNagano, Konami, Takashi Kamimura e Gota Kawai. "Interaction between a fluoroquinolone derivative and RNAs with a single bulge". Journal of Biochemistry 171, n. 2 (16 novembre 2021): 239–44. http://dx.doi.org/10.1093/jb/mvab124.
Testo completoSun, Saisai, Jianyi Yang e Zhaolei Zhang. "RNALigands: a database and web server for RNA–ligand interactions". RNA 28, n. 2 (3 novembre 2021): 115–22. http://dx.doi.org/10.1261/rna.078889.121.
Testo completoTadesse, Kisanet, e Raphael I. Benhamou. "Targeting MicroRNAs with Small Molecules". Non-Coding RNA 10, n. 2 (14 marzo 2024): 17. http://dx.doi.org/10.3390/ncrna10020017.
Testo completoWu, Liping, Jing Pan, Vala Thoroddsen, Deborah R. Wysong, Ronald K. Blackman, Christine E. Bulawa, Alexandra E. Gould et al. "Novel Small-Molecule Inhibitors of RNA Polymerase III". Eukaryotic Cell 2, n. 2 (aprile 2003): 256–64. http://dx.doi.org/10.1128/ec.2.2.256-264.2003.
Testo completoAngelbello, Alicia J., Suzanne G. Rzuczek, Kendra K. Mckee, Jonathan L. Chen, Hailey Olafson, Michael D. Cameron, Walter N. Moss, Eric T. Wang e Matthew D. Disney. "Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model". Proceedings of the National Academy of Sciences 116, n. 16 (29 marzo 2019): 7799–804. http://dx.doi.org/10.1073/pnas.1901484116.
Testo completoAlagia, Adele, Jana Tereňová, Ruth F. Ketley, Arianna Di Fazio, Irina Chelysheva e Monika Gullerova. "Small vault RNA1-2 modulates expression of cell membrane proteins through nascent RNA silencing". Life Science Alliance 6, n. 6 (10 aprile 2023): e202302054. http://dx.doi.org/10.26508/lsa.202302054.
Testo completoFrancois-Moutal, Liberty, David Donald Scott e May Khanna. "Direct targeting of TDP-43, from small molecules to biologics: the therapeutic landscape". RSC Chemical Biology 2, n. 4 (2021): 1158–66. http://dx.doi.org/10.1039/d1cb00110h.
Testo completoSmola, Matthew J., Krista Marran, Sarah E. Thompson, Brittani Patterson, Roheeth K. Pavana, Caleb Sutherland, Jessica A. Sorrentino e Katherine D. Warner. "Abstract 680: Leveraging an RNA-targeting platform for the discovery of cell-active c-MYC mRNA-binding small molecules". Cancer Research 84, n. 6_Supplement (22 marzo 2024): 680. http://dx.doi.org/10.1158/1538-7445.am2024-680.
Testo completoMirón-Barroso, Sofía, Joana S. Correia, Adam E. Frampton, Mark P. Lythgoe, James Clark, Laura Tookman, Silvia Ottaviani et al. "Polymeric Carriers for Delivery of RNA Cancer Therapeutics". Non-Coding RNA 8, n. 4 (2 agosto 2022): 58. http://dx.doi.org/10.3390/ncrna8040058.
Testo completoTesi sul tema "RNA-Targeted small molecules"
Panei, Francesco Paolo. "Advanced computational techniques to aid the rational design of small molecules targeting RNA". Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS106.
Testo completoRNA molecules have recently gained huge relevance as therapeutic targets. The direct targeting of RNA with small molecule drugs emerges for its wide applicability to different classes of RNAs. Despite this potential, the field is still in its infancy and the number of available RNA-targeted drugs remains limited. A major challenge is constituted by the highly flexible and elusive nature of the RNA targets. Nonetheless, RNA flexibility also presents unique opportunities that could be leveraged to enhance the efficacy and selectivity of newly designed therapeutic agents. To this end, computer-aided drug design techniques emerge as a natural and comprehensive approach. However, existing tools do not fully account for the flexibility of the RNA. The project of this PhD work aims to build a computational framework toward the rational design of compounds targeting RNA. The first essential step for any structure-based approach is the analysis of the available structural knowledge. However, a comprehensive, curated, and regularly updated repository for the scientific community was lacking. To fill this gap, I curated the creation of HARIBOSS ("Harnessing RIBOnucleic acid - Small molecule Structures"), a database of all the experimentally-determined structures of RNA-small molecule complexes retrieved from the PDB database. HARIBOSS is available via a dedicated web interface (https://hariboss.pasteur.cloud), and is regularly updated with all the structures resolved by X-ray, NMR, and cryo-EM, in which ligands with drug-like properties interact with RNA molecules. Each HARIBOSS entry is annotated with physico-chemical properties of ligands and RNA pockets. HARIBOSS repository, constantly updated, will facilitate the exploration of drug-like compounds known to bind RNA, the analysis of ligands and pockets properties and, ultimately, the development of in silico strategies to identify RNA-targeting small molecules. In coincidence of its release, it was possible to highlight that the majority of RNA binding pockets are unsuitable for interactions with drug-like molecules, attributed to the lower hydrophobicity and increased solvent exposure compared to protein binding sites. However, this emerges from a static depiction of RNA, which may not fully capture their interaction mechanisms with small molecules. In a broader perspective, it was necessary to introduce more advanced computational techniques for an effective accounting of RNA flexibility in the characterization of potential binding sites. In this direction, I implemented SHAMAN, a computational technique to identify potential small-molecule binding sites in RNA structural ensembles. SHAMAN enables the exploration of the target RNA conformational landscape through atomistic molecular dynamics. Simultaneously, it efficiently identifies RNA pockets using small probe compounds whose exploration of the RNA surface is accelerated by enhanced-sampling techniques. In a benchmark encompassing diverse large, structured riboswitches as well as small, flexible viral RNAs, SHAMAN accurately located experimentally resolved pockets, ranking them as preferred probe hotspots. Notably, SHAMAN accuracy was superior to other tools working on static RNA structures in the realistic drug discovery scenario where only apo structures of the target are available. This establishes SHAMAN as a robust platform for future drug design endeavors targeting RNA with small molecules, especially considering its potential applicability in virtual screening campaigns. Overall, my research contributed to enhance our understanding and utilization of RNA as a target for small molecule drugs, paving the way for more effective drug design strategies in this evolving field
Chung, Janet. "Investigation of small molecule - SL1 RNA interactions and implications in drug design targeted at HIV-1 genomic dimer maturation". Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390040.
Testo completoLibri sul tema "RNA-Targeted small molecules"
Slabý, Ondřej. MicroRNAs in solid cancer: From biomarkers to therapeutic targets. Hauppauge, N.Y: Nova Science, 2011.
Cerca il testo completoCapitoli di libri sul tema "RNA-Targeted small molecules"
Fladung, Matthias, Hely Häggman e Suvi Sutela. "Application of RNAi technology in forest trees." In RNAi for plant improvement and protection, 54–71. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789248890.0007.
Testo completoFladung, Matthias, Hely Häggman e Suvi Sutela. "Application of RNAi technology in forest trees." In RNAi for plant improvement and protection, 54–71. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789248890.0054.
Testo completoUrsu, Andrei, Matthew G. Costales, Jessica L. Childs-Disney e Matthew D. Disney. "Chapter 15. Small-molecule Targeted Degradation of RNA". In Protein Degradation with New Chemical Modalities, 317–36. Cambridge: Royal Society of Chemistry, 2020. http://dx.doi.org/10.1039/9781839160691-00317.
Testo completoDamski, Caio, e Kevin V. Morris. "Targeted Small Noncoding RNA-Directed Gene Activation in Human Cells". In Methods in Molecular Biology, 1–10. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0931-5_1.
Testo completoWilson, W. David, e Ananya Paul. "Reversible Small Molecule–Nucleic Acid Interactions". In Nucleic Acids in Chemistry and Biology, 477–521. The Royal Society of Chemistry, 2022. http://dx.doi.org/10.1039/9781837671328-00477.
Testo completoOktay, Yavuz. "Metabolomiks ve Uygulamaları". In Moleküler Biyoloji ve Genetik, 311–28. Türkiye Bilimler Akademisi, 2023. http://dx.doi.org/10.53478/tuba.978-625-8352-48-1.ch12.
Testo completoHampson, Ian, Gavin Batman e Thomas Walker. "RNA interference technology". In Tools and Techniques in Biomolecular Science. Oxford University Press, 2013. http://dx.doi.org/10.1093/hesc/9780199695560.003.0006.
Testo completoIqbal, Nashra, Priyanka Vishwakarma e Vidya Meenakshi. "NEXT GENERATION SEQUENCING FOR CANCER DIAGNOSIS". In Futuristic Trends in Biotechnology Volume 3 Book 21, 137–51. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bkbt21p1ch11.
Testo completoScarpino, Stefania, e Umberto Malapelle. "Liquid Biopsy: A New Diagnostic Strategy and Not Only for Lung Cancer?" In Histopathology and Liquid Biopsy [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.94838.
Testo completoAtti di convegni sul tema "RNA-Targeted small molecules"
Kahen, Elliot J., Darcy Welch, Jamie Teer, Andrew S. Brohl, Sean J. Yoder, Yonghong Zhang, Ling Cen e Damon Reed. "Abstract 3010: Osteosarcoma cell lines display both shared and unique vulnerabilities to 140 targeted small molecules with RNA-seq revealing putative mechanisms". In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-3010.
Testo completoKahen, Elliot J., Darcy Welch, Jamie Teer, Andrew S. Brohl, Sean J. Yoder, Yonghong Zhang, Ling Cen e Damon Reed. "Abstract 3010: Osteosarcoma cell lines display both shared and unique vulnerabilities to 140 targeted small molecules with RNA-seq revealing putative mechanisms". In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-3010.
Testo completo