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Tesi sul tema "Riidat"

Autore: Grafiati

Pubblicato: 29 luglio 2024

Ultima modifica: 31 luglio 2024

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1

Seppänen, T. (Terhi). "Kannuksen Eskolanharjun, Kälviän Riipan ja Vaasan Kappelinmäen ampumaratojen pilaantuneisuustutkimukset ja riskinarviointi". Master's thesis, University of Oulu, 2013. http://urn.fi/URN:NBN:fi:oulu-201306061573.

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Etelä-Pohjanmaan elinkeino-, liikenne- ja ympäristökeskuksen toiminta-alueella sijaitsee useita ampumaratoja, jotka ovat olleet aktiivisessa tai harrastelijakäytössä. Ampumaradoilla alue käytettyjen haulien ja savikiekkojen käytön vuoksi voi olla pilaantunutta raskasmetalleilla ja polyaromaattisilla hiilivedyillä. Pilaantuneisuus aiheuttaa riskejä niin ihmisille kuin ympäristölleen. Tutkielman tarkoitus oli tutkia kolmen eri ampumaradan pilaantuneisuutta, pilaantuneisuuden laajuutta, ampumaradoille tyypillisten haitta-aineiden osallisuutta pilaantuneisuuteen ja riskinarviointia. Tutkimuksia suoritettiin ampumaradoilla useina vuosina, mutta pääasiallisesti vuosina 2010–2012. Tutkimuksissa kohteista tutkittiin maaperä- ja pohjavesinäytteistä raskasmetallien pitoisuuksia. Tutkimuksissa kyseisten ampumaratojen maaperä oli pilaantunut suurimmaksi osaksi viidellä eri raskasmetallilla. Maaperänäytteiden pitoisuudet havaittiin pääasiassa pintanäytteistä, ja havaitut haitta-aineet olivat ominaisuuksiltaan hitaasti hajoavia sekä huonosti kulkeutuvia. Havaitut haitta-ainepitoisuudet ylittivät paikoitellen pilaantuneelle maalle annetut ohjearvot. Havaituista haitta-aineista lyijy mahdollisesti aiheuttaa suurimman riskin ympäristölle. Pohjavesinäytteistä havaitut pitoisuudet olivat vähäisiä. Tulosten perusteella kyseisillä ampumaradoilla haitta-aineet olivat pilanneet maaperän. Nämä haitta-aineet aiheuttavat riskin ihmisille ja ympäristölle.

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2

Stephens, Lauren Ellis. "Interaction of immunoglobulins with primate Fc[gamma]RIIIa". Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708276.

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3

Heusohn, Frank. "Molekulare Analyse der regulierten Genexpression in NK/T-Zellen am Beispiel des humanen Fc[gamma]RIIIA-Rezeptors [Fc-gamma-RIIIA-Rezeptors]". [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962838004.

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4

Soberón, Mainero Leticia. "La inteligencia conectiva en la Red informática de la Iglesia en América Latina (RIIAL) /". Roma, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000254135.

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5

Cooney, Damon Sean. "Proximal signaling events in Fc[gamma]RIIa-mediated phagocytosis /". The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486397841222421.

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6

Roll, Achim. "Nachweis des Fc[gamma]RIIa-Polymorphismus [Fc-gamma-RIIa-Polymorphismus] bei Patienten mit aggressiver Parodontitis (AP) und einer parodontal gesunden Kontrollgruppe mittels allelspezifischer PCR". Giessen VVB Laufersweiler, 2009. http://d-nb.info/997994878/34.

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7

Rozan, Caroline. "Développement et caractérisation d'anticorps bispécifiques anti-ace xCD16 pour l'immunothérapie des cancers". Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5032.

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Avec quatorze anticorps utilisés en oncologie, les anticorps monoclonaux ont enfin une place de choix dans l'arsenal thérapeutique anticancéreux. Cependant, l'un des modes d'action les plus importants de ces molécules, la cytotoxicité à médiation cellulaire dépendante des anticorps (ADCC), souffre de plusieurs limites en raison de la nécessité d'une interaction optimale avec le FcγRIIIA. L'équipe du Dr. Daniel Baty a conçu de nouveaux formats d'anticorps bispécifiques basés sur l'utilisation de domaine unique d'anticorps de lamas (sdAb) et capables de contourner la plupart de ces limites. Des banques de phages issus de lamas immunisés ont permis de sélectionner deux sdAbs (d'affinités différentes) dirigés contre le FcγRIIIA exprimé par des cellules NK et les macrophages, ainsi qu'un sdAb dirigé contre l'antigène tumoral carcino-embryonnaire (ACE). En utilisant les domaines CH1 et Ck d'IgG1 humaine comme motif d'hétérodimérisation et les sdabs anti-ACE et anti-FcγRIII précédemment sélectionnés, nous avons développé des formats innovants d'anticorps bispécifiques Fab-like nommés bsFabs. Ces molécules sont faciles à produire, très stables et peuvent déclencher la lyse des cellules tumorales par les cellules NK humaines à des concentrations de l'ordre du picomolaire. Elles ne se lient pas au récepteur inhibiteur FcγRIIB, n'entrent pas en compétition avec des IgG sériques pour la liaison aux récepteurs, et leur activité cytotoxique est indépendante de la glycosylation du Fc et du polymorphisme du FcγRIIIA
With fourteen antibodies used in oncology, monoclonal antibodies finally have a place in the therapeutic arsenal against cancer. However one of the modes of action of the most important of these molecules, cell-mediated cytotoxicity antibody-dependent (ADCC), suffers from several limitations due to the need for optimal interaction with the FcγRIIIA. Daniel Baty's team has developed new formats of bispecific antibodies based on the use of single domain llama antibodies (SdAb) that are capable of circumventing most of the these limitations. Phage libraries from immunized llamas were used to select two sdAbs directed against the FcγRIIIA expressed by NK cells and macrophages (with different affinities for FcγRIII), as well as one SdAb directed against the tumor antigen carcinoembryonic (CEA). Using CH1 and Ck domains of human IgG1 as a motif for heterodimerization and sdabs previously selected, we have developed innovative anti-CEA and anti-FcγRIII formats of bispecific antibodies Fab-like named bsFabs. These molecules are easy to produce, very stable and can trigger tumor cell lysis by human NK cells at picomolar concentrations. They do not bind FcγRIIB inhibitory receptor, do not compete with serum IgG and their cytotoxic activity is independent of FcγRIIIA polymorphism. In addition, they slow tumor growth in mouse model. In terms of pharmacokinetics, although bsFabs have a reasonable tumor retention, one of the limitations of these formats is size, which leads to rapid renal elimination. Such findings led us to consider the creation of new antibody formats to both increase tumor retention and secondly the half-life of antibodies in the body

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8

Sadl, Virginia. "Herpes virus-based packaging systems for gene delivery of the RIIA sodium channel". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq29774.pdf.

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9

Sadl, Virginia. "Herpes virus-based packaging systems for gene delivery of the RIIA sodium channel". Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=27399.

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To investigate the localization and targeting of sodium channels in neurons, an efficient means of gene delivery will need to be established. Two amplicon-based viral approaches and a recombinant whole virus approach were attempted in order to package and express RIIA sodium channel tagged with a c-myc epitope (RIIA-myc) with the ultimate purpose of developing a Herpes virus-based model system for targeting studies.
Immunofluorescent staining of transfected epithelial cells was carried out to demonstrate that constructs created for use in these HSV-based approaches were capable of a high level of expression of RIIA-myc. Measurements of $ beta$-galactosidase reporter gene expression observed in cultured cells infected with RIIA amplicon virus suggested successful packaging of amplicon DNA. However, RIIA-myc expression from amplicon virus was not apparent, which may suggest recombination events occurred upon packaging of constructs. Difficulties in selection for recombinants with acyclovir prevented the recombinant whole virus approach from being pursued.

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10

Allred, Laura K. "Polymorphic variants of Human Fc-GAMMA-RIIIa, gamma-chain, CTLA-4 and Fc-GAMMA-RIIb1 : possible implications for systemic Lupus Erythematosus Pathogenesis /". The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486394475979377.

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11

Beil, Elizabeth. "Identification of fcγRIIA STAT6 Interaction and the Subsequent Effects". University of Toledo Health Science Campus / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=mco1332933291.

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12

Junnila, Riia Karoliina [Verfasser], Gudrun [Akademischer Betreuer] Brockmann, Werner [Akademischer Betreuer] Kloas e Christian [Akademischer Betreuer] Strasburger. "In vitro characterization of human growth hormone mutants / Riia Karoliina Junnila. Gutachter: Gudrun Brockmann ; Werner Kloas ; Christian Strasburger". Berlin : Humboldt Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://d-nb.info/1015046517/34.

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13

Ertner, Julia Kathrin [Verfasser], e Christoph [Akademischer Betreuer] Garlichs. "Fc-gamma-RIIa- und Gen-Polymorphismen des C-reaktiven Proteins bei Patienten mit koronarer Restenose / Julia Kathrin Ertner. Betreuer: Christoph Garlichs". Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2013. http://d-nb.info/103677497X/34.

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14

Roll, Achim [Verfasser]. "Nachweis des FcγRIIa-Polymorphismus [Fc-gamma-RIIa-Polymorphismus] bei Patienten mit aggressiver Parodontitis (AP) und einer parodontal gesunden Kontrollgruppe mittels allelspezifischer PCR / vorgelegt von Achim Roll". Giessen : VVB Laufersweiler, 2009. http://d-nb.info/997994878/34.

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15

Iriemenam, Nnaemeka C. "Antibody responses and Fc gamma receptor IIa polymorphism in relation to Plasmodium falciparum malaria". Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-27541.

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Immunity to asexual blood-stage of Plasmodium falciparum malaria is believed to be associated with protective antibodies of certain immunoglobulin classes and subclasses. This thesis addressed the importance of antibodies in relation to malaria infection and their effective interactions with Fc gamma receptor IIa (FcyRIIa) polymorphisms. Our data indicate that the frequency of FcyRIIa-R/R131 genotype was statistically significantly higher in Sudanese patients with severe malaria, while the FcyRIIa-H/H131 genotype showed a significant association with mild malaria. The levels of IgG1 and IgG3 subclass antibodies were statistically higher in the mild malaria patients. The Fulani ethnic group in West Africa has been shown to be relatively resistant to malaria. We investigated the possible impact of FcyRIIa polymorphisms in the Fulani and non-Fulani in Mali and Sudan, and analysed their malaria-reactive IgG subclass profiles. The FcyRIIa-H/H131 genotype and H131-allele were found to be prevalent in the Fulani while R131-allele was prevalent in non-Fulani. The Fulani had higher serum levels of IgG1-3, with higher proportion of IgG2 than the non-Fulani. Most clinico-epidemiology studies have been in areas with holo- and hyper-malaria endemicity. We have analysed antibody responses to a panel of six blood-stage antigens in relation to clinical malaria outcome in mesoendemic Sudan. Our results revealed a linear association with anti-AMA-1 IgG1 antibodies and reduced risk of severe malaria while a non-linear relationship with IgG3 antibodies was observed for MSP-2, MSP-3 and GLURP. In the combined final model, the highest levels of IgG1 subclass antibodies to AMA-1, GLURP-R0, and the highest levels of IgG3 subclass antibodies reactive to 3D7 MSP-2 were independently associated with a reduced risk of clinical malaria. Taken together, these data suggest a possible association between FcyRIIa-R/H131 and anti-malarial antibody responses in the clinical outcome of malaria.

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16

Major, Michael A. "Participatory communication in development integrating women into forestry projects in Costa Riica /". 1987. http://catalog.hathitrust.org/api/volumes/oclc/17503086.html.

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Thesis (M.S.)--University of Wisconsin--Madison, 1987.
Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 114-118).

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17

Renner, Riitta Susanna [Verfasser]. "Etablierung eines murinen Lungentumormodells zur Untersuchung von ortsspezifischer magnetischer Deposition und Ultraschall-induzierter Freisetzung von siRNA / von Riitta Susanna Renner". 2009. http://d-nb.info/993528368/34.

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18

Zhang, Christine. "Trafficking of FcγRIIA and FcγRIIB2 upon Endocytosis of Immune Complexes". Thesis, 2012. http://hdl.handle.net/1807/35753.

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Fcγ receptors (FcγR) which recognize the Fc fraction of IgG play key roles in the modulation of a range of cellular responses as part of the host defense against foreign microbes and antigens. An important function of FcγR is to mediate internalization of soluble IgG-containing immune complexes via endocytosis. The mechanisms of internalization and intracellular transport of FcγR after internalization are less clear. In this thesis, I investigated the trafficking behaviours of human FcγRIIA and FcγRIIB2 upon clustering with immune complexes. In Chapter 3, I demonstrate FcγRIIA, when engaged with multivalent heat aggregated IgG (agIgG), is delivered along with its ligand to lysosomal compartments for degradation, whereas FcγRIIB2 becomes dissociated from the ligand and routed separately into a recycling pathway. FcγRIIA sorting to lysosomes requires receptor multimerization, but does not require either Src family kinase (SFK) activity or receptor ubiquitylation. Upon co-engagement, these two receptors are sorted independently to distinct final fates after dissociating from their co-clustering ligand. In Chapter 4, I show that while the ubiquitin-conjugating system is required for FcγRIIA-mediated endocytosis, it is not required for FcγRIIB2 endocytosis. FcγRIIB2 internalizes immune complexes at a faster rate than FcγRIIA and accelerates the endocytosis of FcγRIIA upon receptor co-engagement. Taken together, these results reveal fundamental differences in the trafficking behaviour of FcγRIIA and FcγRIIB2 both during the initial induction of endocytosis as well as during subsequent intracellular sorting.

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19

Cendron, Angela. "The development of peptide-based inhibitors of the low affinity Fc receptor, Fc [gamma] RIIa". Thesis, 2005. https://vuir.vu.edu.au/15580/.

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FcyRIIa is an activatory receptor and contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain, involved in the initiation of signalling events. There is now strong evidence from transgenic mouse models and human genetic susceptibility studies that implicate FcyRIIa in a number of immune diseases including, rheumatoid arthritis, systemic lupus erythematosus (SLE) and immune thrombocytopenia purpura (ITP). FcyRHa is therefore a promising target for the development of therapeutics to treat these diseases.

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20

Heusohn, Frank [Verfasser]. "Molekulare Analyse der regulierten Genexpression in NK/T-Zellen am Beispiel des humanen FcγRIIIA-Rezeptors [Fc-gamma-RIIIA-Rezeptors] / von Frank Heusohn". 2001. http://d-nb.info/962838004/34.

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21

Sarkar, Saumendra Narayan. "Expressing And Characterization Of Rat Brain Sodium Channels In Cho Cells". Thesis, 1995. https://etd.iisc.ac.in/handle/2005/1602.

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22

Sarkar, Saumendra Narayan. "Expressing And Characterization Of Rat Brain Sodium Channels In Cho Cells". Thesis, 1995. http://etd.iisc.ernet.in/handle/2005/1602.

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23

PIGHI, CHIARA. "Impact of anti-CD20 tumor-targeting therapeutic monoclonal antibodies on human Natural Killer cell responsiveness and plasticity: relevance of FcgammaRIIIA/CD16 affinity ligation conditions". Doctoral thesis, 2018. http://hdl.handle.net/11573/1116013.

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My study is focused on understanding the mechanisms underlying the modulation of NK cell responsiveness and plasticity induced by tumor targeting therapeutic anti-CD20 monoclonal antibodies (mAbs) nowadays routinely used in the treatment of B-cell malignancies and autoimmune disorders. Anti-CD20 mAbs are grouped into type I and II subtypes. Type I mAbs induce CD20 redistribution into lipid rafts and display a remarkable ability to activate complement-dependent cytotoxicity (CDC). On the other hand, type II mAbs, which are not able to localize CD20 complexes into lipid rafts and induce weak or no CDC, evoke more homotypic adhesion and direct killing of target cells. Both type I and II mAbs demonstrate efﬁcient phagocytosis and antibody-dependent cytotoxicity (ADCC). Natural Killer (NK) cell-mediated ADCC, based on the recognition of IgG-opsonized targets by the low affinity Fc receptor for IgG FcgammaRIIIA/CD16, represents one of the main mechanisms by which anti-CD20 mAbs mediate their anti-tumor effects. Besides ADCC, CD16 ligation also results in the production of cytokines such as IFN-gamma that plays a key role in the shaping of adaptive immune responses. Rituximab is a chimeric type I anti-CD20 mAb of 1st generation and is considered the reference molecule for the comparison with new generation anti-CD20 mAbs, designed to optimize clinical efficacy. Among them, obinutuzumab is a humanized Fc-glycoengineered type II anti-CD20 mAb of 3rd generation designed to increase the affinity for CD16 receptor and consequently the killing of mAb-opsonized targets. However, the impact of CD16 ligation in optimized affinity conditions on NK functional program is not completely understood. Herein, I demonstrated that CD16 affinity ligation conditions may dictate both the amplitude of NK responsiveness (cytotoxicity and IFN-gamma production) as well as the ability to shift the NK functional program. Indeed, I observed that the interaction of NK cells with obinutuzumab-opsonized targets results in enhanced cytotoxicity and IFN-gamma production as compared with the parental non-glycoengineered mAb or the reference molecule rituximab, independently from the CD16-158V/F allotype. The affinity ligation conditions also strictly correlate with the ability to induce CD16 surface down-modulation and lysosomal targeting of receptor-coupled signaling elements. Indeed, a preferential degradation of FcepsilonRIgamma chain and Syk tyrosine kinase was observed upon obinutuzumab stimulation independently from the CD16-158V/F allotype. Notably, although the down-regulation of FcepsilonRIgamma/Syk module hesitates in the impairment of cytotoxic function induced by CD16, NKp46 and NKp30 activating receptors, obinutuzumab-experienced NK cells exhibit an increased ability to produce IFN-gamma in response to cytokines and target stimulation as well as to obinutuzumab-mediated CD16 re-stimulation. Relying on the observation that obinutuzumab-experienced NK cells, under molecular and functional profile, resemble the distinctive features of the long-lived and highly functional “memory” NK cells, a population recently identified in HCMV seropositive individuals, I assessed the capability of anti-CD20 mAbs to affect the expansion as well as the phenotypic and functional properties of the “memory” NK subset. My data show that the majority of the analysed healthy donors is HCMV seropositive and exhibits a detectable population of “memory” NK cells (CD3- CD56+ FcepsilonRIgamma- CD16+) accounting for 3 to 50% of peripheral blood NK cells. I observed that “memory” NK cells selectively undergo 2- to 12-fold expansion upon co-culturing with anti-CD20-opsonized targets; on the opposite, the proliferation of “conventional” NK cells (CD3- CD56+ FcepsilonRIgamma+ CD16+) is not affected by CD16 stimulation. I also noted that anti-CD20 mAb in vitro expanded “memory” NK cells show the molecular and functional hallmarks of their freshly isolated counterpart, including the increased expression of NKG2C receptor, the reduced expression of NKp46 receptor associated to an enhanced functional activity in response to CD16 re-stimulation, particularly in terms of IFN-gamma production.

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24

Mangold, Melanie [Verfasser]. "Interaktion von C-reaktivem Protein mit FcγRI [Fc-gamma-RI] und FcγRIIa [Fc-gamma-RIIa] auf COS-7 Zellen: bindet CRP an Fc-Rezeptoren? / vorgelegt von Melanie Mangold". 2004. http://d-nb.info/995612684/34.

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