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Letteratura scientifica selezionata sul tema "Riidat"

Autore: Grafiati

Pubblicato: 29 luglio 2024

Ultima modifica: 31 luglio 2024

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Articoli di riviste sul tema "Riidat"

Gachet, C., A. Astier, H. de la Salle, C. de la Salle, WH Fridman, JP Cazenave, D. Hanau e JL Teillaud. "Release of Fc gamma RIIa2 by activated platelets and inhibition of anti- CD9-mediated platelet aggregation by recombinant Fc gamma RIIa2". Blood 85, n. 3 (1 febbraio 1995): 698–704. http://dx.doi.org/10.1182/blood.v85.3.698.bloodjournal853698.

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Thrombin-activated human platelets and megakaryocyte cell lines release soluble Fc gamma RII (Fc gamma RIIa2) containing the extracellular and intracellular regions of Fc gamma RIIa1, but lacking the transmembrane domain. Use of polyclonal antibodies directed either against the entire intracytoplasmic tail, or against a peptide located near the C-terminal part of the intracellular region of Fc gamma RIIa2, showed the presence of both a complete form of Fc gamma RIIa2 and a C-terminal truncated form in supernatants of platelets after release of their alpha granule contents and in culture supernatants of megakaryocyte cell lines. Furthermore, recombinant Fc gamma RIIa2 inhibited in a dose-dependent manner Fc-dependent anti-CD9 antibody-induced platelet aggregation. Thus, release of Fc gamma RIIa2 by activated platelets could play an important role in the regulation of platelet activation by immune complexes.

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Indik, ZK, JG Park, S. Hunter e AD Schreiber. "The molecular dissection of Fc gamma receptor mediated phagocytosis". Blood 86, n. 12 (15 dicembre 1995): 4389–99. http://dx.doi.org/10.1182/blood.v86.12.4389.bloodjournal86124389.

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Because hematopoietic cells express multiple Fc gamma receptor isoforms, the role of the individual Fc gamma receptors in phagocytosis has been difficult to define. Transfection of Fc gamma receptors into COS-1 cells, which lack endogeneous Fc gamma receptors but have phagocytic potential, has proved valuable for the study of individual Fc gamma receptor function. Using this model system, we have established that a single class of human Fc gamma receptor mediates phagocytosis in the absence of other Fc receptors and that isoforms from each Fc gamma receptor class mediate phagocytosis, although the requirements for phagocytosis differ. In investigating the relationship between structure and function for Fc gamma receptor mediated phagocytosis, the importance of the cytoplasmic tyrosines of the receptor or its associated gamma chain has been established. For example, two cytoplasmic YXXL sequences, in a configuration similar to the conserved tyrosine-containing motif found in Ig gene family receptors, are important for phagocytosis by the human Fc gamma receptor, Fc gamma RIIA. Fc gamma RI and Fc gamma RIIIA do not possess cytoplasmic tyrosines but transmit a phagocytic signal through interaction with an associated gamma subunit that contains two YXXL sequences in a conserved motif required for phagocytosis. The human Fc gamma RII isoforms Fc gamma RIIB1 and Fc gamma RIIB2 do not induce phagocytosis and have only a single YXXL sequence. Cross-linking the phagocytic Fc gamma receptors induces tyrosine phosphorylation of either Fc gamma RIIA or the gamma chain, and treatment with tyrosine kinase inhibitors reduces both phagocytosis and phosphorylation of the receptor tyrosine residues. Activation of protein tyrosine kinases follows Fc gamma receptor engagement of IgG-coated cells. The data indicate that coexpression of the protein tyrosine kinase Syk, which is associated with the gamma chain in monocytes/macrophages, is important for phagocytosis mediated by Fc gamma RI and Fc gamma RIIIA. Furthermore, phosphatidylinositol-3 kinase is required for phagocytosis mediated by Fc gamma RIIA as well as for phagocytosis mediated by Fc gamma RI/gamma and Rc gamma RIIIA/gamma.

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Weng, Wen-Kai, Jeffrey Stavenhagen, Scott Koenig e Ronald Levy. "Rituximab Variants with Re-Engineered Fc with Higher Affinity to Activating Fcγ R Eliminate the Functional Difference between Fcγ R Genotypes." Blood 106, n. 11 (16 novembre 2005): 347. http://dx.doi.org/10.1182/blood.v106.11.347.347.

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Abstract We and others have found that IgG Fc receptor, Fcγ RIIIa Valine/Valine (V/V) and Fcγ RIIa Histidine/Histidine (H/H) genotypes predicted the response to rituximab in follicular lymphoma patients probably due to their higher affinity to the constant region (Fc) of rituximab during antibody-dependent cellular cytotoxicity (ADCC). Patients with low affinity Fcγ RIIIa Phenylalanine (F) carrier (V/F and F/F) and Fcγ RIIa Arginine (R) carrier (H/R and R/R) have much lower chance to respond to rituximab and have a brief remission when they responded. This observation implicates the interaction between the Fc of rituximab and Fcγ R on effectors (NK cells and macrophages) as a determinant for clinical response. Therefore, it may be possible to re-engineer the Fc of rituximab to increase its affinity to Fcγ R and thereby to enhance the antibody’s ability to mediate ADCC and to improve its clinical efficacy. Rituximab variants with re-engineered Fc were generated by MacroGenics. Single amino acid substitutions with increased affinity to different Fcγ R alleles were identified by screening a yeast library containing randomly mutated Fc. Further re-engineering was accomplished by combining multiple amino acid substitutions within both the Fcγ R-binding CH2 and the conformational CH3 domains of the Fc to further improve their affinity. We have tested 12 such variants for their ability to mediate ADCC against primary follicular lymphoma targets. Three variants (4, 10, 12) showed significant enhancement in ADCC compared to rituximab, using effector cells of V/V genotype. We then tested whether the enhancement of ADCC applies to effectors of different Fcγ RIIIa genotypes. In one experiment, at a 30:1 effector/target ratio, specific ADCC lysis for rituximab, Variant 6 (a modest enhancer) and Variant 10 (a strong enhancer) were 37%, 50% and 66%, respectively, with V/V effectors and 23%, 36% and 65%, respectively, with F/F effectors. Thus, enhancement of ADCC by these variants applied to effectors of both high (V/V) and low (F/F) affinity Fcγ Rs. In one case, Variant 10, enhancement of ADCC with effctors of low affinity Fcγ R, brought its activity up to that of effectors with the high affinity Fcγ R. We further examined the ability of these variants to engage and internalize the Fcγ R on NK cells as a measure of primary engagement of Fcγ R. Rituximab-coated tumor cells reduced the surface Fcγ RIIIa on NK cells of V/V genotype by 78% determined by flow cytometric analysis. By comparison, Variant 6 down-regulated surface Fcγ RIIIa by 84% and Variant 10 by 88%. For NK cells of F/F genotype, rituximab down-regulated surface Fcγ RIIIa by 32%, Variant 6 by 64% and Variant 10 by 68%. This result confirmed that two rituximab variants were more effective in interacting with effectors of both high and low affinity Fcγ Rs. This study has demonstrated that several rituximab variants with re-engineered Fc showed increased interaction with Fcγ R on effectors and mediated ADCC more effectively than rituximab even with effectors of low affinity Fcγ R genotypes. These rituximab variants may prove to be more effective therapeutic anti-CD20 antibodies than rituximab, especially for patients with low affinity Fcγ Rs. Figure Figure

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Meisel, P., LE Carlsson, H. Sawaf, J. Fanghaenel, A. Greinacher e T. Kocher. "Polymorphisms of Fcγ-receptors RIIa, RIIIa, and RIIIb in patients with adult periodontal diseases". Genes & Immunity 2, n. 5 (agosto 2001): 258–62. http://dx.doi.org/10.1038/sj.gene.6363777.

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Riis, Erling, Lars-Ulrik Andersen, Nis Bjerre, Ove Poulsen, Siu-Au Lee e John L. Hall. "Riiset al.Reply". Physical Review Letters 62, n. 7 (13 febbraio 1989): 842. http://dx.doi.org/10.1103/physrevlett.62.842.

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Ahlgrimm, Manfred, Evi Regitz, Klaus-Dieter Preuss, Sandra Grass, Viola Poeschel, Markus Kreuz e Michael Pfreundschuh. "Single Nucleotide Polymorphisms (SNPs) of FCγRIIA and FCγRIIIA in Patients with Diffuse Large B-Cell Lymphoma Have No Impact On Treatment Outcome of Elderly Patients with Diffuse Large B-Cell Lymphoma (DLBCL) Treated with CHOP with and without Rituximab: Results From the RICOVER-60 Trial of the German High-Grade Non-Hodgkin Lymhoma Study Group (DSHNHL)." Blood 114, n. 22 (20 novembre 2009): 3956. http://dx.doi.org/10.1182/blood.v114.22.3956.3956.

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Abstract Abstract 3956 Poster Board III-892 BACKGROUND During the last decade the outcome of patients with diffuse large B-cell lymphoma (DLBCL) has significantly improved by the addition of rituximab (R) to the standard chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP). Despite this improvement in response rates, event- progression and overall survival, about one third of the patients with DLBCL will eventually fail. The main therapeutic efficacy of rituximab is not fully elucidated. One major effector mechanism is by antibody dependent cellular cytotoxicity (ADCC) mediated by cell-bound rituximab via its FCg part that activates effector cells by binding to their Fcg receptor (FCγR). Three classes and eight subclasses of FCγR have been described. SNPs have been detected for FcgRIIA at amino acid position (AA) 131 where histidin is substituted by arginin (131 R/H) and for FCγRIIIA at position 158, where phenylalanine is substituted by valine (158 V/F). These SNPs have an increased affinity to Fcg and induce a stronger ADCC which explains better responses to rituximab treatment in follicular lymphoma. The aim of this study was to determine the impact of FCγRIIA and FCγRIIIA SNPs on the outcome R-CHOP chemotherapy in elderly patients with newly diagnosed DLBCL. PATIENTS AND METHODS In the RICOVER-60 therapy study 1222 elderly patients (aged 61-80 years) were randomly assigned to 6 or 8 cycles of CHOP, both with or without rituximab (Pfreundschuh et al., Lancet Oncology 2008). The control group (n=100) consisted of anonymous healthy blood donors of Saarland University Institute of Transfusion Medicine. Available for this study were peripheral blood samples from 570 patients who were representative for the entire RICOVER-60 population. The 2 FCgR SNPs FCγ-RIIa AA 131 R/H and FCγ-RIIIa 158 V/F were determined and univariate and multivariate analyses adjusting for the IPI-relevant risk factors (LDH, ECOG performance status, advanced stage and >1 extranodal involvement) were performed for the entire study population and separately for patients receiving or not receiving rituximab. RESULTS Frequencies of FCγ-RIIa and FCγ-RIIIa polymorphisms were not different in healthy controls compared to DLBCL patients. In our statistical analyses finaly 512 patients were included. The characteristic for the groups were for group 1 (6x CHOP-14) 127 patients (24.8%), for group 2 (8x CHOP-14) 122 patients (23.83%), for group 3 (6x CHOP-14+8x rituximab) 124 patients (24.22%) and for group 4 (8x CHOP-14 + 8x rituximab) 139 patients (27.15%) [fisher test (included vs excluded): p=0.4691]. The median age at admission was the same for included and excluded patients. The gender characteristics for the included patients were well balanced [fisher test (included vs excluded): p=1.0000]. The median observation time for the included vs. excluded patients was 40.25 months vs. 34.50 months. This verification shows that the collective of included patients represents the whole RICOVER-60 population. Statistical analyses of overall survival, 3 year event-free survival and 3 year overall-survival were done for the complete RICOVER-60 population. 3-year event-free survival was 47.2% after six cycles of CHOP-14 (95% CI 41.2-53.3), 53.0% (47.0-59.1) after eight cycles of CHOP-14, 66.5% (60.9-72.0) after six cycles of R-CHOP-14, and 63.1% (57.4-68.8) after eight cycles of R-CHOP-14. 3-year overall survival was 67.7% (62.0-73.5) for six cycles of CHOP-14, 66.0% (60.1-71.9) for eight cycles of CHOP-14, 78.1% (73.2-83.0) for six cycles of R-CHOP-14, and 72.5% (67.1-77.9) for eight cycles of R-CHOP-14. Compared with treatment with six cycles of CHOP-14, overall survival improved by -1.7% (-10.0-6.6) after eight cycles of CHOP-14, 10.4% (2.8-18.0) after six cycles of R-CHOP-14, and 4.8% (-3.1-12.7) after eight cycles of R-CHOP-14. In summary, event-free, progression free, overall survival and complete remission rates were not different among patients with FCγ-RIIa (AA 131R/H) and FCγ-RIIIa (AA 158 V/F) SNPs, irrespective of whether the entire RICOVER-60 population was analysed or when patients treated with and without rituximab were analysed separately. CONCLUSIONS FCγ-RIIa and FCγ-RIIIa SNPs have no influence on the outcome of patients treated with CHOP-14 with or without rituximab. Therefore, modifications of schedule and dose of rituximab according to the underlying FCγ-R SNPs are not justified. Supported by a HOMFOR grant of Saarland University Medical School, Homburg, Germany Disclosures: Pfreundschuh: Roche MabThera Advisory Board: Consultancy, Honoraria.

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Matsuda, M., J. G. Park, D. C. Wang, S. Hunter, P. Chien e A. D. Schreiber. "Abrogation of the Fc gamma receptor IIA-mediated phagocytic signal by stem-loop Syk antisense oligonucleotides." Molecular Biology of the Cell 7, n. 7 (luglio 1996): 1095–106. http://dx.doi.org/10.1091/mbc.7.7.1095.

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The role of Syk kinase in Fc gamma receptor (Fc gamma R) IIA-mediated phagocytosis was examined with two forms of antisense oligodeoxynucleotides (ODNs) designed to hybridize to human Syk mRNA. Monocytes were incubated with linear and stem-loop antisense ODNs targeted to Syk mRNA. When complexed with cationic liposomes, stem-loop Syk antisense ODN with phosphorothioate modification exhibited stability in fetal bovine and human serum. The stem-loop Syk antisense ODN at a concentration of 0.2 microM inhibited Fc gamma RIIA-mediated phagocytosis by 90% and completely eliminated Syk mRNA and protein in monocytes, whereas scrambled-control ODNs had no effect. The Syk antisense ODNs did not change beta-actin mRNA levels and Fc gamma RII cell-surface expression. In addition, stem-loop Syk antisense ODN inhibited Fc gamma RI and Fc gamma RIIIA-mediated phagocytosis. These data indicate the efficacy of stem-loop Syk antisense ODN for targeting and degrading Syk mRNA and protein and the importance of Syk kinase in Fc gamma receptor-mediated phagocytosis. Immunoblotting assay demonstrated that Fc gamma RII tyrosine phosphorylation after Fc gamma RII cross-linking did not change in the absence of Syk protein. These results indicate that Syk kinase is required for Fc gamma RIIA-mediated phagocytic signaling and that Fc gamma RII cross-linking leads to tyrosine phosphorylation of Fc gamma RII independent of Syk kinase.

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Edberg, J. C., e R. P. Kimberly. "Cell type-specific glycoforms of Fc gamma RIIIa (CD16): differential ligand binding." Journal of Immunology 159, n. 8 (15 ottobre 1997): 3849–57. http://dx.doi.org/10.4049/jimmunol.159.8.3849.

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Abstract Fc gamma RIIIa, considered an intermediate affinity receptor, can variably bind monomeric IgG and appears to have a higher affinity for IgG than the lower affinity Fc gamma Rs, Fc gamma RII and Fc gamma RIIIb. We explored this property for both NK cell and monocyte Fc gamma RIIIa and found higher affinity ligand binding by Fc gamma RIIIa expressed on NK cells compared with Fc gamma RIIIa on monocytes. In normal whole blood or plasma (containing 8-11 mg/ml IgG), NK cell Fc gamma RIIIa was fully blocked, but in monocytes Fc gamma RIIIa showed approximately 60% blockade of the binding of mAb 3G8, which binds in or near the ligand binding site. The ligand binding site of NK cell Fc gamma RIIIa was blocked with as little as 2 mg/ml of human IgG, while monocyte Fc gamma RIIIa was only partially (30%) blocked by 2 mg/ml of human IgG. In contrast, plasma containing approximately 26 mg/ml of IgG (obtained from patients receiving therapeutic gamma-globulin) showed complete saturation of monocyte Fc gamma RIIIa with blockade of mAb 3G8 binding. These binding differences are not due to allelic polymorphisms or primary sequence differences between donors. Although NK cell and monocyte Fc gamma RIIIa have identical protein cores, they each undergo differential cell type-specific glycosylation. NK cell Fc gamma RIIIa is glycosylated with high mannose- and complex-type oligosaccharides, while monocyte Fc gamma RIIIa has no high mannose-type oligosaccharides. These results indicate that natural glycoforms of Fc gamma RIIIa (cell type-specific glycosylation variants) bind ligand differently, conferring a lower affinity on monocyte/macrophage Fc gamma RIIIa, which makes the receptor ideal for initial immune complex capture and sensitive to moderate changes in serum IgG levels.

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de Haas, M., H. R. Koene, M. Kleijer, E. de Vries, S. Simsek, M. J. van Tol, D. Roos e A. E. von dem Borne. "A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa." Journal of Immunology 156, n. 8 (15 aprile 1996): 2948–55. http://dx.doi.org/10.4049/jimmunol.156.8.2948.

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Abstract A donor-dependent difference in electrophoretic mobility of deglycosylated released Fc gamma RIIIa derived from NK cells and macrophages was observed. We investigated whether this was based on a polymorphism of the Fc gamma RIIIA gene. Cloning and sequencing of Fc gamma RIIIa-encoding cDNA derived from an apparently heterozygous donor showed one single nucleotide substitution at position 230 (T-->G), which was responsible for a leucine (L)-->arginine (R) substitution at position 48 in the first extracellular Ig-like domain (EC1) of Fc-gamma RIIIa and caused a higher electrophoretic mobility of Fc gamma RIIIa. An allele-specific primer annealing PCR assay was developed to amplify specifically an Fc gamma RIIIA gene-derived fragment, which was digested with AciI (recognizing G230) or MnlI (recognizing T230). MnlI restriction analysis revealed the presence of a third Fc gamma RIIIa allele with a T230-->A substitution, which predicts a change of 48-leucine into 48-histidine (H). A gene frequency of 86% for the T230 (48-L) allele, 6% for G230 (48-R), and 8% for A230 (48-H) was found. A significantly different genotype distribution was found among 12 unrelated Caucasian Fc gamma RIIIB gene-deficient donors. Fc gamma RIIIa-48R and Fc gamma RIIIa-48H showed a higher binding capacity of human (h)IgG1, hIgG3, and hIgG4 compared with Fc gamma RIIIa-48L. Finally, the CD16 mAbs 1D3 and MEM154 bound more strongly and Leu11c (B73.1) bound less to the newly identified Fc gamma RIIIa isoforms.

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Chen, Tiffany F., Stephen L. Sazinsky, Damian Houde, David J. DiLillo, Julie Bird, Kevin K. Li, George T. Cheng et al. "Engineering Aglycosylated IgG Variants with Wild-Type or Improved Binding Affinity to Human Fc Gamma RIIA and Fc Gamma RIIIAs". Journal of Molecular Biology 429, n. 16 (agosto 2017): 2528–41. http://dx.doi.org/10.1016/j.jmb.2017.07.001.

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Più fonti

Tesi sul tema "Riidat"

Seppänen, T. (Terhi). "Kannuksen Eskolanharjun, Kälviän Riipan ja Vaasan Kappelinmäen ampumaratojen pilaantuneisuustutkimukset ja riskinarviointi". Master's thesis, University of Oulu, 2013. http://urn.fi/URN:NBN:fi:oulu-201306061573.

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Etelä-Pohjanmaan elinkeino-, liikenne- ja ympäristökeskuksen toiminta-alueella sijaitsee useita ampumaratoja, jotka ovat olleet aktiivisessa tai harrastelijakäytössä. Ampumaradoilla alue käytettyjen haulien ja savikiekkojen käytön vuoksi voi olla pilaantunutta raskasmetalleilla ja polyaromaattisilla hiilivedyillä. Pilaantuneisuus aiheuttaa riskejä niin ihmisille kuin ympäristölleen. Tutkielman tarkoitus oli tutkia kolmen eri ampumaradan pilaantuneisuutta, pilaantuneisuuden laajuutta, ampumaradoille tyypillisten haitta-aineiden osallisuutta pilaantuneisuuteen ja riskinarviointia. Tutkimuksia suoritettiin ampumaradoilla useina vuosina, mutta pääasiallisesti vuosina 2010–2012. Tutkimuksissa kohteista tutkittiin maaperä- ja pohjavesinäytteistä raskasmetallien pitoisuuksia. Tutkimuksissa kyseisten ampumaratojen maaperä oli pilaantunut suurimmaksi osaksi viidellä eri raskasmetallilla. Maaperänäytteiden pitoisuudet havaittiin pääasiassa pintanäytteistä, ja havaitut haitta-aineet olivat ominaisuuksiltaan hitaasti hajoavia sekä huonosti kulkeutuvia. Havaitut haitta-ainepitoisuudet ylittivät paikoitellen pilaantuneelle maalle annetut ohjearvot. Havaituista haitta-aineista lyijy mahdollisesti aiheuttaa suurimman riskin ympäristölle. Pohjavesinäytteistä havaitut pitoisuudet olivat vähäisiä. Tulosten perusteella kyseisillä ampumaradoilla haitta-aineet olivat pilanneet maaperän. Nämä haitta-aineet aiheuttavat riskin ihmisille ja ympäristölle.

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Stephens, Lauren Ellis. "Interaction of immunoglobulins with primate Fc[gamma]RIIIa". Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708276.

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Heusohn, Frank. "Molekulare Analyse der regulierten Genexpression in NK/T-Zellen am Beispiel des humanen Fc[gamma]RIIIA-Rezeptors [Fc-gamma-RIIIA-Rezeptors]". [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962838004.

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Soberón, Mainero Leticia. "La inteligencia conectiva en la Red informática de la Iglesia en América Latina (RIIAL) /". Roma, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000254135.

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Cooney, Damon Sean. "Proximal signaling events in Fc[gamma]RIIa-mediated phagocytosis /". The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486397841222421.

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Roll, Achim. "Nachweis des Fc[gamma]RIIa-Polymorphismus [Fc-gamma-RIIa-Polymorphismus] bei Patienten mit aggressiver Parodontitis (AP) und einer parodontal gesunden Kontrollgruppe mittels allelspezifischer PCR". Giessen VVB Laufersweiler, 2009. http://d-nb.info/997994878/34.

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Rozan, Caroline. "Développement et caractérisation d'anticorps bispécifiques anti-ace xCD16 pour l'immunothérapie des cancers". Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5032.

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Avec quatorze anticorps utilisés en oncologie, les anticorps monoclonaux ont enfin une place de choix dans l'arsenal thérapeutique anticancéreux. Cependant, l'un des modes d'action les plus importants de ces molécules, la cytotoxicité à médiation cellulaire dépendante des anticorps (ADCC), souffre de plusieurs limites en raison de la nécessité d'une interaction optimale avec le FcγRIIIA. L'équipe du Dr. Daniel Baty a conçu de nouveaux formats d'anticorps bispécifiques basés sur l'utilisation de domaine unique d'anticorps de lamas (sdAb) et capables de contourner la plupart de ces limites. Des banques de phages issus de lamas immunisés ont permis de sélectionner deux sdAbs (d'affinités différentes) dirigés contre le FcγRIIIA exprimé par des cellules NK et les macrophages, ainsi qu'un sdAb dirigé contre l'antigène tumoral carcino-embryonnaire (ACE). En utilisant les domaines CH1 et Ck d'IgG1 humaine comme motif d'hétérodimérisation et les sdabs anti-ACE et anti-FcγRIII précédemment sélectionnés, nous avons développé des formats innovants d'anticorps bispécifiques Fab-like nommés bsFabs. Ces molécules sont faciles à produire, très stables et peuvent déclencher la lyse des cellules tumorales par les cellules NK humaines à des concentrations de l'ordre du picomolaire. Elles ne se lient pas au récepteur inhibiteur FcγRIIB, n'entrent pas en compétition avec des IgG sériques pour la liaison aux récepteurs, et leur activité cytotoxique est indépendante de la glycosylation du Fc et du polymorphisme du FcγRIIIA
With fourteen antibodies used in oncology, monoclonal antibodies finally have a place in the therapeutic arsenal against cancer. However one of the modes of action of the most important of these molecules, cell-mediated cytotoxicity antibody-dependent (ADCC), suffers from several limitations due to the need for optimal interaction with the FcγRIIIA. Daniel Baty's team has developed new formats of bispecific antibodies based on the use of single domain llama antibodies (SdAb) that are capable of circumventing most of the these limitations. Phage libraries from immunized llamas were used to select two sdAbs directed against the FcγRIIIA expressed by NK cells and macrophages (with different affinities for FcγRIII), as well as one SdAb directed against the tumor antigen carcinoembryonic (CEA). Using CH1 and Ck domains of human IgG1 as a motif for heterodimerization and sdabs previously selected, we have developed innovative anti-CEA and anti-FcγRIII formats of bispecific antibodies Fab-like named bsFabs. These molecules are easy to produce, very stable and can trigger tumor cell lysis by human NK cells at picomolar concentrations. They do not bind FcγRIIB inhibitory receptor, do not compete with serum IgG and their cytotoxic activity is independent of FcγRIIIA polymorphism. In addition, they slow tumor growth in mouse model. In terms of pharmacokinetics, although bsFabs have a reasonable tumor retention, one of the limitations of these formats is size, which leads to rapid renal elimination. Such findings led us to consider the creation of new antibody formats to both increase tumor retention and secondly the half-life of antibodies in the body

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Sadl, Virginia. "Herpes virus-based packaging systems for gene delivery of the RIIA sodium channel". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq29774.pdf.

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Sadl, Virginia. "Herpes virus-based packaging systems for gene delivery of the RIIA sodium channel". Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=27399.

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To investigate the localization and targeting of sodium channels in neurons, an efficient means of gene delivery will need to be established. Two amplicon-based viral approaches and a recombinant whole virus approach were attempted in order to package and express RIIA sodium channel tagged with a c-myc epitope (RIIA-myc) with the ultimate purpose of developing a Herpes virus-based model system for targeting studies.
Immunofluorescent staining of transfected epithelial cells was carried out to demonstrate that constructs created for use in these HSV-based approaches were capable of a high level of expression of RIIA-myc. Measurements of $ beta$-galactosidase reporter gene expression observed in cultured cells infected with RIIA amplicon virus suggested successful packaging of amplicon DNA. However, RIIA-myc expression from amplicon virus was not apparent, which may suggest recombination events occurred upon packaging of constructs. Difficulties in selection for recombinants with acyclovir prevented the recombinant whole virus approach from being pursued.

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Allred, Laura K. "Polymorphic variants of Human Fc-GAMMA-RIIIa, gamma-chain, CTLA-4 and Fc-GAMMA-RIIb1 : possible implications for systemic Lupus Erythematosus Pathogenesis /". The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486394475979377.

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Libri sul tema "Riidat"

Konttinen, Riitta. Taiteilijapareja: Riitta Konttinen. Helsingissä: Otava, 1991.

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Buongiorno, Pino. Totò Riina. Milano: Rizzoli, 1993.

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G, Baumanis, a cura di. Riga-Pori-Riika. [Rīga]: Rīgas pilsētas Tauts deputātu padomes izpildkomiteja, 1988.

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Saranpää, Timo. Näyttöenemmyysperiaate riita-asiassa. Helsinki: Suomalainen lakimiesyhdistys, 2010.

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Ervasti, Kaijus. Oikeudenkäyntikulut pääkäsittelyyn edenneissä riita-asioissa. Helsinki: Oikeuspoliittinen tutkimuslaitos, 1997.

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Paasilinna, Erno. Riita maailman kanssa: Kirjoituksia neljältä vuosikymmeneltä. Helsingissä: Otava, 1997.

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Torrealta, Maurizio. Ultimo: Il capitano che arrestò Totò Riina. Milano: Feltrinelli, 1995.

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Raudsepp, Anu. Riia Vaimulik Seminar: 1846-1918. Tartu: Eesti Kirjandusmuuseum, 1998.

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Pantaleone, Michele. Omertà di Stato: Da Salvatore Giuliano a Totò Riina. Napoli: Pironti, 1993.

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Valter, Hannes. Landeswehri sõjast ; Võnnu lahingust ; Riia operatsioonist. Tallinn: Perioodika, 1989.

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Capitoli di libri sul tema "Riidat"

Parmar, Inderjeet. "Sociology of the CFR and RIIA". In Think Tanks and Power in Foreign Policy, 24–47. London: Palgrave Macmillan UK, 2004. http://dx.doi.org/10.1057/9780230000780_2.

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Parmar, Inderjeet. "CFR-RIIA Interconnections: A Transnational Ruling Class, Liberal Atlantic Community or Anglo-American Establishment?" In Think Tanks and Power in Foreign Policy, 189–214. London: Palgrave Macmillan UK, 2004. http://dx.doi.org/10.1057/9780230000780_8.

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"Empty spaces without knowledge and management: Riitta Kuusinen". In Information Society and the Workplace, 76–93. Routledge, 2012. http://dx.doi.org/10.4324/9780203402658-12.

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"Bone Plates and Screws, Bioabsorbable / Riitta Suuronen, Christian Lindqvist". In Encyclopedia of Biomaterials and Biomedical Engineering, 464–70. CRC Press, 2008. http://dx.doi.org/10.1201/9780429154065-44.

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Lehtinen, Anna-Riitta, e Kristiina Aalto. "Reference budgets as tools for everyday life, evaluation and policy making in Finland". In Minimum Income Standards and Reference Budgets, 109–22. Policy Press, 2020. http://dx.doi.org/10.1332/policypress/9781447352952.003.0008.

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Abstract (sommario):

This chapter tackles Anna-Riitta Lehtinen and Kristiina Aalto's work on reference budget methods in Finland in order to establish the decent minimum reference budgets. It illustrates some attempts that were made to establish a programme of reference budget research in the 1990s. It also mentions how reference budget research was revived by Lehtinen and Aalto's work on consensual budgets in 2010 and then in 2018. The chapter examines how the Finnish reference budgets combine focus group discussions with members of the public in order to help improve the reliability and validity of the resulting standards. It reveals the inadequacy of the Finnish social protection system, in which only pensioner incomes reached the reference budget standard while other cash transfers and benefits were about 70 percent of the reference budgets.

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"Riitta Katila Shares How Public/Private Firm Collaborations Became a Research Interest". In Machine Learning and Public/Private Firm Collaboration. United Kingdom: SAGE Publications, Ltd., 2023. http://dx.doi.org/10.4135/9781529666779.n1.

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Noorhani, Piret. "Kohtumispaik Riia. Loodi Balti Audiovisuaalsete Arhiivide Kolleegium". In Võim ja kultuur 2, 381–90. ELM Scholarly Press, 2006. http://dx.doi.org/10.7592/vk2.2006.noorhani.

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"Riitta Katila Discusses Research Methods Using Machine Learning to Study Public/Private Firm Collaborations". In Machine Learning and Public/Private Firm Collaboration. United Kingdom: SAGE Publications, Ltd., 2023. http://dx.doi.org/10.4135/9781529666779.n3.

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"Riitta Katila Discusses Research Question and Design Using Machine Learning to Study Public/Private Firm Collaborations". In Machine Learning and Public/Private Firm Collaboration. United Kingdom: SAGE Publications, Ltd., 2023. http://dx.doi.org/10.4135/9781529666779.n2.

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"Riitta Katila Discusses Data Collection, Analysis, and Findings for Research Using Machine Learning to Study Public/Private Firm Collaborations". In Machine Learning and Public/Private Firm Collaboration. United Kingdom: SAGE Publications, Ltd., 2023. http://dx.doi.org/10.4135/9781529666779.n4.

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Atti di convegni sul tema "Riidat"

Guha, Rutan. "Session details: RIIT Paper 2". In SIGITE/RIIT '15: The 16th Annual Conference on Information Technology Education and the 4th Annual Conference on Research in Information Technology. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/3247531.

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Olagunju, Amos O. "Session details: RIIT Paper 4". In SIGITE/RIIT '15: The 16th Annual Conference on Information Technology Education and the 4th Annual Conference on Research in Information Technology. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/3247530.

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Paterson, Bill. "Session details: RIIT Paper 1". In SIGITE/RIIT '15: The 16th Annual Conference on Information Technology Education and the 4th Annual Conference on Research in Information Technology. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/3247526.

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Sobiesk, Ed. "Session details: RIIT Paper 3". In SIGITE/RIIT '15: The 16th Annual Conference on Information Technology Education and the 4th Annual Conference on Research in Information Technology. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/3247528.

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Steinbach, Terry. "Session details: RIIT lightning talks". In SIGITE/RIIT'14: SIGITE/RIIT 2014. New York, NY, USA: ACM, 2014. http://dx.doi.org/10.1145/3246651.

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Sobiesk, Ed. "Session details: RIIT Lightning Talk 2". In SIGITE/RIIT '15: The 16th Annual Conference on Information Technology Education and the 4th Annual Conference on Research in Information Technology. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/3247529.

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Paterson, Bill. "Session details: RIIT Lightning Talk 1". In SIGITE/RIIT '15: The 16th Annual Conference on Information Technology Education and the 4th Annual Conference on Research in Information Technology. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/3247527.

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Lunt, Barry M., Kaylee Richmond e Dale C. Rowe. "A Profile of SIGITE/RIIT Authors". In SIGITE/RIIT 2016: The 17th Annual Conference on Information Technology Education and the 5th Annual Conference on Research in Information Technology. New York, NY, USA: ACM, 2016. http://dx.doi.org/10.1145/2978192.2978211.

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Tis, Bruce P. "Session details: C1: RIIT Paper Session". In SIGITE/RIIT 2016: The 17th Annual Conference on Information Technology Education and the 5th Annual Conference on Research in Information Technology. New York, NY, USA: ACM, 2016. http://dx.doi.org/10.1145/3248749.

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Renwick, Janet S. "Session details: C2: RIIT Paper Session". In SIGITE/RIIT 2016: The 17th Annual Conference on Information Technology Education and the 5th Annual Conference on Research in Information Technology. New York, NY, USA: ACM, 2016. http://dx.doi.org/10.1145/3248750.

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Rapporti di organizzazioni sul tema "Riidat"

Wright, Michael, Eric Sword e James Younkin. Feasibility and Demonstration of a Cloud-Based RIID Analysis System Annual Report. Office of Scientific and Technical Information (OSTI), ottobre 2013. http://dx.doi.org/10.2172/1096325.

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Johnson, William C. Annual Report: Feasibility and Demonstration of a Cloud-Based RIID Analysis System. Office of Scientific and Technical Information (OSTI), ottobre 2014. http://dx.doi.org/10.2172/1172784.

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