Bibliografie tematiche / Resveratrol

Letteratura scientifica selezionata sul tema "Resveratrol"

Autore: Grafiati
Pubblicato: 4 giugno 2021
Ultima modifica: 25 maggio 2024

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Articoli di riviste sul tema "Resveratrol"

1

Zhong, Zixing, Xin Guo e Yanmei Zheng. "Network Pharmacology-based and Molecular Docking Analysis of Resveratrol’s Pharmacological Effects on Type I Endometrial Cancer". Anti-Cancer Agents in Medicinal Chemistry 22, n. 10 (giugno 2022): 1933–44. http://dx.doi.org/10.2174/1871520621666211015140455.

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Background: Resveratrol is a natural polyphenol commonly seen in foods. It has demonstrated an inhibitive effect on endometrial cancer, but the molecular action is still not known. Objective: We aimed to use network pharmacology to systematically study the possible mechanisms of resveratrol’s pharmacological effects on type I endometrial cancer. Methods: Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) were used to predict resveratrol’s possible target genes. They were then converted to UniProt gene symbols. Simultaneously, type I endometrial cancer-related target genes were collected from GeneCards. All data were pooled to identify common target genes. The protein-protein interaction (PPI) network was constructed and further analyzed via STRING Online Database. Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway were also performed afterward. To visualise resveratrol's overall pharmacological effects on type I endometrial cancer, a network of drug components-target gene-disease (CTD) was constructed. Then, we performed in silico molecular docking study to validate the possible binding conformation between resveratrol and candidate targets. Results: There are 150 target genes of resveratrol retrieved after UniProt conversion; 122 of them shared interaction with type I endometrial cancer. Some important oncogenes and signaling pathways are involved in the process of resveratrol’s pharmacological effects on endometrioid cancer. Molecular docking analysis confirmed that hydrogen bonding and hydrophobic interaction are the main interaction between resveratrol and its targets. Conclusion: We have explored the possible underlying mechanism of resveratrol in antagonising type I endometrial cancer through a network pharmacology-based approach and in-silico verification. However, further experiments are necessary to add to the evidence identifying resveratrol as a promising anti-type I endometrial cancer agent.
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2

Jang, Ae-Ra, Jun-Sang Ham, Dong-Wook Kim, Kuk-Hwan Seol, Mi-Hwa Oh, Hyun-Seok Chae, Sang-Ho Kim e Dong-Hun Kim. "Dietary Supplementation of Resveratrol and Methoxylated Resveratrol Affects on Chicken Thigh Meat Quality". Korean Journal of Poultry Science 38, n. 4 (31 dicembre 2011): 315–22. http://dx.doi.org/10.5536/kjps.2011.38.4.315.

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3

Peng, Han, e Fereidoon Shahidi. "The Effects of Acyl Chain Length on Antioxidant Efficacy of Mono- and Multi-Acylated Resveratrol: A Comparative Assessment". Molecules 27, n. 3 (2 febbraio 2022): 1001. http://dx.doi.org/10.3390/molecules27031001.

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Abstract (sommario):
Acylated derivatives of the dietary phenolic, resveratrol, were prepared via enzymatic and chemical transesterification modification with selected vinyl fatty acids to expand the potential application of resveratrol and its acylated derivatives in functional supplement, cosmetic/skincare, and pharmaceutical fields. The acylation was implemented using eight vinyl fatty acids with varying chain lengths (C2:0-C18:0). Eight monoesters enzymatically prepared, eight diesters and four triesters, chemically prepared, were isolated and purified and identified via MS (mass spectra) or/and NMR (nuclear magnetic resonance). The lipophilicity of resveratrol and its acylated derivatives was calculated using ALOGPS 2.1. Compared with related acylated products, resveratrol itself rendered higher antioxidant efficacy in all the antioxidant assays, namely DPPH, ABTS, FRAP, and ferrous chelation tests. Within various ester derivatives of resveratrol, short-chain fatty acid mono- and di-substituted resveratrols, especially the resveratrol monoacetate/diacetate, exhibited higher antioxidant efficacy in DPPH and ABTS assays than the rest of resveratrol derivatives, but the medium-chain monoesters of resveratrol, including caproate, caprylate, caprate, and laurate, showed a higher metal ion chelation ability compared to other acylated resveratrols. These results imply that resveratrol derivatives may be used in lipidic media as health-beneficial antioxidants.
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4

Yanagi, Masayoshi, Noriyuki Uchida e Hiroki Hamada. "Versatile Synthetic Route for Resveratrol Modification via Amine Functionalization". Natural Product Communications 14, n. 9 (settembre 2019): 1934578X1987621. http://dx.doi.org/10.1177/1934578x19876210.

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Resveratrol derivatives containing a primary amine functional group were synthesized by an introduction of N-Boc-bromoethylamine to resveratrol using Williamson ether synthesis and subsequent deprotection of the Boc group with trifluoroacetic acid. After conjugation of fluorescent NBD-F or rhodamine B with isothiocyanate (Rhd B-ITC) using the amine group, resveratrols modified with NBD or Rhd B (Resveratrol-NBD and Resveratrol-Rhd B, respectively) were successfully obtained.
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Alquisiras-Burgos, Iván, Irma Gabriela González-Herrera, Sergio Alcalá-Alcalá e Penélope Aguilera. "Nose-to Brain Delivery of Resveratrol, a Non-Invasive Method for the Treatment of Cerebral Ischemia". Drugs and Drug Candidates 3, n. 1 (26 gennaio 2024): 102–25. http://dx.doi.org/10.3390/ddc3010007.

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Abstract (sommario):
Cerebral ischemia represents a particular condition among neurological diseases due to its high frequency, high associated mortality, and the permanent disability in patients that survive it. Numerous studies in animal models have demonstrated the protective properties of resveratrol against cerebral ischemia. Resveratrol is a soluble molecule in polar solvents with high membrane permeability; however, it is rapidly metabolized at the liver and is also a substrate of the ATP binding cassette transporters located at the blood–brain barrier. These circumstances reduced bioavailability of resveratrol to the brain. In this review, we examined nasal resveratrol’s formulations including nanocarriers such as nanostructured lipid carriers, nanoemulsions, nanoparticles, bilosomes, cubosomal, and transferosomes that are directly transported to the brain. An intranasal administration route evades resveratrol transformation due to liver metabolism. Components of nanoformulations increased resveratrol absorption to the brain by enhancing permeation through specific approaches and also maintaining stability during storage. Both characteristics improved the delivery of resveratrol with conserved antioxidant capacity and protective properties for neurological models. Although demonstration that the nanoformulations prevents resveratrol’s blood–brain barrier retention is missing, properties of resveratrol’s nanoformulation encourage testing in clinical trials; however, regulatory approval for a novel nanocarrier in nasal drug delivery is complicated and needs approval.
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Novakovic, Radmila, Nebojsa Radunovic, Jovana Rajkovic, Vladimir Djokic, Aleksandar Petrovic, Branka Ivkovic, Vitomir Cupic, Vladimir Kanjuh, Helmut Heinlev e Ljiljana Gojkovic-Bukarica. "Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels". Veterinarski glasnik 70, n. 3-4 (2016): 121–29. http://dx.doi.org/10.2298/vetgl1604121n.

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Abstract (sommario):
Resveratrol is a phytoalexin produced in a number of plant species including grapes. The benefit of resveratrol to health is widely reported. Resveratrol has been found to promote relaxation of non-pregnant and pregnant uterus, but its mechanism of action is unclear. The aims of our study were to investigate the involvement of inwardly rectifying potassium channels (Kir) in inhibitory effects of resveratrol on three models of contractions of non-pregnant rat uterus: the spontaneous rhythmic contractions (SRC), oxytocin-elicited phasic contractions and tonic oxytocin-elicited contractions.Uterine strips were obtained from virgin female Wistar rats in oestrus. Strips were mounted into organ bath for recording isometric tension in Krebs-Ringer solution. Experiments followed a multiple curve design. In order to test the involvement of Kirchannels in a mechanism of action of resveratrol(1-100 ?M),BaCl2 (1 mM),a antagonist of inwardly rectifying pota?ssium channels was used. Resveratrol induced a concentration-dependent relaxation of all models of contractions. BaCl2 antagonized the response to resveratrolon SRC and oxytocin-elicited phasic contractions. Relaxation achieved by resveratrolon tonic oxytocin-elicited concentrations was insensitive to BaCl2.The antagonism of resveratrol effects by inwardly rectifying potassium channels antagonist suggests that Kir channels are involved in resveratrol action on phasic contractions of rat uterus. Inhibitory effect of resveratrol on tonic contractions did not include Kir channels.
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Luís, Ângelo, Helena Marcelino, Fernanda Domingues, Luísa Pereira e José Francisco Cascalheira. "Therapeutic Potential of Resveratrol for Glioma: A Systematic Review and Meta-Analysis of Animal Model Studies". International Journal of Molecular Sciences 24, n. 23 (22 novembre 2023): 16597. http://dx.doi.org/10.3390/ijms242316597.

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Abstract (sommario):
Gliomas are aggressive malignant brain tumors, with poor prognosis despite available therapies, raising the necessity for finding new compounds with therapeutic action. Numerous preclinical investigations evaluating resveratrol’s anti-tumor impact in animal models of glioma have been reported; however, the variety of experimental circumstances and results have prevented conclusive findings about resveratrol’s effectiveness. Several databases were searched during May 2023, ten publications were identified, satisfying the inclusion criteria, that assess the effects of resveratrol in murine glioma-bearing xenografts. To determine the efficacy of resveratrol, tumor volume and animal counts were retrieved, and the data were then subjected to a random effects meta-analysis. The influence of different experimental conditions and publication bias on resveratrol efficacy were evaluated. Comparing treated to untreated groups, resveratrol administration decreased the tumor volume. Overall, the effect’s weighted standardized difference in means was −2.046 (95%CI: −3.156 to −0.936; p-value < 0.001). The efficacy of the treatment was observed for animals inoculated with both human glioblastoma or rat glioma cells and for different modes of resveratrol administration. The combined administration of resveratrol and temozolomide was more effective than temozolomide alone. Reducing publication bias did not change the effectiveness of resveratrol treatment. The findings suggest that resveratrol slows the development of tumors in animal glioma models.
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Boo, Yong Chool. "Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications". Antioxidants 8, n. 9 (22 agosto 2019): 332. http://dx.doi.org/10.3390/antiox8090332.

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Abstract (sommario):
Antioxidants are deemed useful in controlling oxidative stress associated with extrinsic skin aging and pigmentation disorders. Resveratrol is a polyphenol compound found in many edible plants such as Vitis vinifera, and its inhibitory effects on the catalytic activity, gene expression, and posttranslational modifications of tyrosinase, a key enzyme in the melanin biosynthetic pathway, provide a mechanistic basis for its antimelanogenic effects seen in melanocytic cells, three-dimensionally reconstituted skin models, and in vivo animal models. As a potent antioxidant and a modulator of nuclear factor erythroid 2-related factor 2 (Nrf2), and sirtuin 1, resveratrol can also regulate multiple signaling pathways associated with inflammation and premature aging. Recent clinical studies have supported the efficacy of resveratrol and its analogs, such as resveratryl triacetate (RTA) and resveratryl triglycolate (RTG), in human skin lightening and antiaging. These findings suggest that resveratrol and its analogs are potentially useful as skin lightening and antiaging agents in cosmetics.
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Farhan, Mohd, e Asim Rizvi. "The Pharmacological Properties of Red Grape Polyphenol Resveratrol: Clinical Trials and Obstacles in Drug Development". Nutrients 15, n. 20 (23 ottobre 2023): 4486. http://dx.doi.org/10.3390/nu15204486.

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Abstract (sommario):
Resveratrol is a stilbenoid from red grapes that possesses a strong antioxidant activity. Resveratrol has been shown to have anticancer activity, making it a promising drug for the treatment and prevention of numerous cancers. Several in vitro and in vivo investigations have validated resveratrol’s anticancer capabilities, demonstrating its ability to block all steps of carcinogenesis (such as initiation, promotion, and progression). Additionally, resveratrol has been found to have auxiliary pharmacological effects such as anti-inflammatory, cardioprotective, and neuroprotective activity. Despite its pharmacological properties, several obstacles, such as resveratrol’s poor solubility and bioavailability, as well as its adverse effects, continue to be key obstacles to drug development. This review critically evaluates the clinical trials to date and aims to develop a framework to develop resveratrol into a clinically viable drug.
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Chen, Xiangxiu, Xu Song, Xinghong Zhao, Yu Zhang, Yiming Wang, Renyong Jia, Yuanfeng Zou, Lixia Li e Zhongqiong Yin. "Insights into the Anti-inflammatory and Antiviral Mechanisms of Resveratrol". Mediators of Inflammation 2022 (12 agosto 2022): 1–11. http://dx.doi.org/10.1155/2022/7138756.

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Abstract (sommario):
Resveratrol is a naturally occurring stilbene phytoalexin phenolic compound, which has been extensively studied on its biological activity. It has been widely accepted that resveratrol possesses anti-inflammatory and antiviral activities. In this review, we summarize the anti-inflammatory dosages and mechanism and antiviral mechanism of resveratrol. Since viral infections are often accompanied by inflammation, we propose that the NF-κB signaling pathway is a key and common molecular mechanism of resveratrol to exert anti-inflammatory and antiviral effects. For future studies, we believe that resveratrol’s anti-inflammatory and antiviral mechanisms can consider the upstream signaling molecules of the NF-κB signaling pathway. For resveratrol antivirus, future studies can be conducted on the interaction of resveratrol with key proteins or important enzymes of the virus. In addition, we also think that the clinical application of resveratrol is very important. In short, resveratrol is a promising anti-inflammatory and antiviral drug, and research on it needs to be expanded.
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Più fonti

Tesi sul tema "Resveratrol"

1

Carvalho, Paula Andréa Sampaio de Vasconcelos [UNESP]. "Concentração de resveratrol e expressão de resveratrol sintase em espécies de Arichis". Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/108549.

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O resveratrol é uma fitoalexina produzida em função de estresses bióticos e abióticos e foi encontrado em um número limitado de espécies de plantas, incluindo o amendoim (Arachis hypogaea) e seus parentes silvestres. Este tem também propriedades antioxidantes e em função disso é um promissor antitumoral, cardioprotetor e neuroprotetor. O amendoim é um alotetraploide de constituição genômica AB sendo A. ipaënsis e A. duranensis os doadores de seus genomas B e A, respectivamente. Estudos prévios demonstraram que algumas espécies silvestres do gênero Arachis produzem resveratrol e que ampla variabilidade genética para diferentes características existe entre acessos das espécies silvestres, incluindo ampla variação nos níveis de resistência a doenças fúngicas e nematoides. Portanto, a avaliação de um maior número do gênero e a investigação da variação da produção de resveratrol também entre acessos é fundamental para uma exploração mais adequada das espécies silvestres do gênero Arachis. O melhor entendimento das causas da variação na produção de resveratrol sem dúvida contribuirá para o uso das mesmas e o primeiro passo para esse entendimento sem duvida passa pela identificação do padrão de expressão da resveratrol sintase (RS). Este trabalho tem como objetivos avaliar a variação na produção de resveratrol entre espécies (A. hypogaea, A. stenosperma, A. valida, A. wiliamsii, A. duranensis, A. ipaënsis e um anfidiploide sintético proveniente do cruzamento artificial entre A. duranensis e A. ipaënsis) e entre acessos de duas espécies(A. hypogaea e A. stenosperma) por meio de HPLC e avaliar a expressão relativa da resveratrol sintase por meio de RT-qPCR em A. hypogaea, A. duranensis, A. ipaënsis e um anfidiploide sintético. Folhas foram coletadas de plantas cultivadas em casa de vegetação para os grupos teste e controle e três repetições biológicas ...
Resveratrol is a phytoalexin produced under biotic and abiotic stresses. It has been found in a restricted number of plant species including peanut (Arachis hypogaea) and its wild relatives. This phytochemical has antioxidant properties, being considered a promising antitumour, cardioprotective and neuroprotective agent. Peanut is an allotetraploid specie with an AABB genomic constitution. Arachis ipaënsis and A. duranensis are the donors of the B genome and the A genome, respectively. Previous studies have shown that wild species of the genus Arachis can produce resveratrol. Therefore, the evaluation of other species of thus genus and the analysis of the variation in the production of resveratrol between accessions is essential for better exploitation of wild species in the genus Arachis. It also important the understanding of the variation in resveratrol concentration between species and accessions and that could be reached through the better understating of the role resveratrol synthase.. . The aims of this work were to evaluate the variation in resveratrol production between species (A. hypogaea, A. stenosperma, A. valida, A. wiliamsii, A. duranensis, A. ipaënsis and in a synthetic amphidiploid derived from these two wild species A. duranensis and A. ipaënsis) and between accessions of the same specie (A. hypogaea and A. stenosperma) through HPLC, and to quantify the expression of resveratrol synthase by RT-qPCR in A. hypogaea, A. duranensis, A. ipaënsis and in a synthetic amphidiploid. Leaves for the test and control groups were collected from plants cultivated in a greenhouse and three biological replicates were evaluated for each specie. The synthesis of resveratrol in leaves was induced by treatment with UV for 2 hours and thirty minutes and then the difference in the concentration of resveratrol between species and between the accessions and cultivars of the same species was analyzed. We found new ...
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Carvalho, Paula Andréa Sampaio de Vasconcelos. "Concentração de resveratrol e expressão de resveratrol sintase em espécies de Arichis /". Botucatu, 2013. http://hdl.handle.net/11449/108549.

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Orientador: Marcos Aparecido Gimenes
Coorientador: Tânia da Silveira Agostini Costa
Coorientador: Ana Cristina Miranda Brasileiro
Banca: Marcia Ortiz Mayo Marques
Banca: Edvaldo Aparecido Amaral da Silva
Resumo: O resveratrol é uma fitoalexina produzida em função de estresses bióticos e abióticos e foi encontrado em um número limitado de espécies de plantas, incluindo o amendoim (Arachis hypogaea) e seus parentes silvestres. Este tem também propriedades antioxidantes e em função disso é um promissor antitumoral, cardioprotetor e neuroprotetor. O amendoim é um alotetraploide de constituição genômica AB sendo A. ipaënsis e A. duranensis os doadores de seus genomas B e A, respectivamente. Estudos prévios demonstraram que algumas espécies silvestres do gênero Arachis produzem resveratrol e que ampla variabilidade genética para diferentes características existe entre acessos das espécies silvestres, incluindo ampla variação nos níveis de resistência a doenças fúngicas e nematoides. Portanto, a avaliação de um maior número do gênero e a investigação da variação da produção de resveratrol também entre acessos é fundamental para uma exploração mais adequada das espécies silvestres do gênero Arachis. O melhor entendimento das causas da variação na produção de resveratrol sem dúvida contribuirá para o uso das mesmas e o primeiro passo para esse entendimento sem duvida passa pela identificação do padrão de expressão da resveratrol sintase (RS). Este trabalho tem como objetivos avaliar a variação na produção de resveratrol entre espécies (A. hypogaea, A. stenosperma, A. valida, A. wiliamsii, A. duranensis, A. ipaënsis e um anfidiploide sintético proveniente do cruzamento artificial entre A. duranensis e A. ipaënsis) e entre acessos de duas espécies(A. hypogaea e A. stenosperma) por meio de HPLC e avaliar a expressão relativa da resveratrol sintase por meio de RT-qPCR em A. hypogaea, A. duranensis, A. ipaënsis e um anfidiploide sintético. Folhas foram coletadas de plantas cultivadas em casa de vegetação para os grupos teste e controle e três repetições biológicas ...
Abstract: Resveratrol is a phytoalexin produced under biotic and abiotic stresses. It has been found in a restricted number of plant species including peanut (Arachis hypogaea) and its wild relatives. This phytochemical has antioxidant properties, being considered a promising antitumour, cardioprotective and neuroprotective agent. Peanut is an allotetraploid specie with an AABB genomic constitution. Arachis ipaënsis and A. duranensis are the donors of the B genome and the A genome, respectively. Previous studies have shown that wild species of the genus Arachis can produce resveratrol. Therefore, the evaluation of other species of thus genus and the analysis of the variation in the production of resveratrol between accessions is essential for better exploitation of wild species in the genus Arachis. It also important the understanding of the variation in resveratrol concentration between species and accessions and that could be reached through the better understating of the role resveratrol synthase.. . The aims of this work were to evaluate the variation in resveratrol production between species (A. hypogaea, A. stenosperma, A. valida, A. wiliamsii, A. duranensis, A. ipaënsis and in a synthetic amphidiploid derived from these two wild species A. duranensis and A. ipaënsis) and between accessions of the same specie (A. hypogaea and A. stenosperma) through HPLC, and to quantify the expression of resveratrol synthase by RT-qPCR in A. hypogaea, A. duranensis, A. ipaënsis and in a synthetic amphidiploid. Leaves for the test and control groups were collected from plants cultivated in a greenhouse and three biological replicates were evaluated for each specie. The synthesis of resveratrol in leaves was induced by treatment with UV for 2 hours and thirty minutes and then the difference in the concentration of resveratrol between species and between the accessions and cultivars of the same species was analyzed. We found new ...
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Nemen, Daiane. "Sistemas nanoestruturados lipídicos contendo resveratrol". reponame:Repositório Institucional da UFSC, 2012. http://repositorio.ufsc.br/xmlui/handle/123456789/93866.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2010
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O resveratrol (RV) é um polifenol pertencente à classe dos estilbenos, presente na dieta humana. Esta substância tem demonstrado inúmeras atividades farmacológicas incluindo antitumoral, anti-inflamatória, antioxidante, cardioprotetora, entre outras. Entretanto, a biodisponibilidade oral desta substância é praticamente nula, em decorrência do seu elevado metabolismo colônico e hepático. Por outro lado, estudos relatam os benefícios do RV sobre a pele, fazendo com que a liberação tópica deste composto constitua uma interessante alternativa à administração oral para o tratamento de várias desordens cutâneas. Neste sentido, a nanoencapsulação do RV pode ser considerada uma alternativa promissora para a aplicação tópica cutânea. Neste trabalho, nanopartículas lipídicas sólidas (NLS), nanoemulsões (NE) e microemulsões (ME) foram preparadas pela técnica de difusão do solvente a quente e avaliadas quanto a sua capacidade de incorporar o RV, assim como de liberar este fármaco através da pele. Visando uma forma farmacêutica para uso tópico, nanogéis foram preparados pela adição de hidroxietilcelulose às dispersões coloidais. Um método analítico por CLAE foi desenvolvido e validado, com o intuito de determinar a concentração de RV nas formulações e monitorar a concentração de fármaco permeado ou retido na pele. O tamanho médio das partículas foi aproximadamente de 221, 119 e 22 nm, para as NLSs, NEs e MEs, respectivamente. Todas as preparações apresentaram potencial zeta negativo. Elevados valores de eficiência de encapsulação foram obtidos para todas as formulações testadas. Entretanto, o teor de RV variou significativamente em função do tipo de nanocarreador e da quantidade de fármaco inicialmente adicionada às formulações. Em especial, a ME apresentou uma maior capacidade de incorporar o RV, aumentando a sua concentração cerca de 28 vezes em relação a sua solubilidade aquosa. As formulações em dispersão e em gel foram avaliadas em estudos de permeação cutânea utilizando células de difusão tipo Franz e pele de orelha de porco como modelo de membrana por um período de 8 horas. O fluxo de permeação, o tempo de latência e o coeficiente de permeabilidade foram estimados após a construção do gráfico da quantidade permeada (µg/cm²) versus tempo (h). Estudos de microscopia confocal de varredura laser (MCVL) foram realizados no intuito de observar a difusão do fármaco incorporado nas NLSs, NEs e MEs através da pele, utilizando o vermelho de Nilo (VN) como marcador fluorescente. A permeação e a retenção do RV foram significativamente afetadas pelo tipo de nanocarreador lipídico. O fluxo e o coeficiente de permeabilidade diminuíram na seguinte ordem: MERV < NLSRV < NERV. Por outro lado, a quantidade permeada através da pele aumentou após a aplicação da ME apresentando a mais elevada concentração de fármaco, quando MEs com diferentes teores de RV foram testadas. O tempo de latência não variou para a maioria das formulações, e a quantidade de fármaco retido na pele demonstrou ser significativamente reduzida, somente quando as NLS foram aplicadas. As fotomicrografias obtidas por MCVL evidenciaram a permeação do VN nas camadas profundas da pele quando as dispersões coloidais foram testadas, o que não foi observado com uma solução do mesmo utilizada como controle, em que o marcador fluorescente permaneceu nas camadas superficiais da pele. Além disso, a menor penetração do corante a partir das MEs pode ser visualizada, confirmando os resultados obtidos nos estudos de permeação.
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Ressler, Daniel. "Synthesis of Resveratrol Ester Derivatives". Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etd/1234.

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The goal of this research project was to synthesize derivatives of transresveratrol. In order for resveratrol to be activated and used by the body it needs to bind to Human Serum Albumin (HSA), a protein in blood plasma. The derivatives were synthesized to improve the ability of resveratrol to enter cells as well as improve their ability to bind to HSA. The three derivatives that were synthesized have converted one of the hydroxyl groups on resveratrol to an ether with a methylene chain terminated by a carboxylic acid. By varying the lengths of the methylene chain we varied the water solubility of the resveratrol derivative. This brought the research closer to the goal of determining how this would affect the binding ability to HSA. Currently three derivatives have been synthesized and purified once by column chromatography.
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Wang, Shan [Verfasser]. "The effect of resveratrol and resveratrol imine analogues on human tumor cell lines / Shan Wang". Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2016. http://d-nb.info/1107794242/34.

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6

Bradaschia, Alice. "Resveratrol, a natural molecule against hypertension and cardiovascular diseases: development of prodrugs to enhance its bioavailability". Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422913.

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Plant polyphenols are a vast family of natural compounds present in many foods and drinks. Many of them have noteworthy biological properties. Resveratrol, for example, can help prevent cardiovascular disease in humans, because it is able to lower blood pressure and lipid peroxidation, to induce vasodilatation and to reduce platelet aggregation. Moreover, resveratrol has antioxidant, anti-inflammatory, and anti-atherosclerotic properties, resulting in protection of the cardiovascular system, improvement of age-related cognitive decline and prevention and therapy of cancer. These potential positive effects are hampered by the low bioavailability of this compound and of polyphenols in general. As a result of a low level of absorption and a rapid metabolism in intestinal and liver cells, only small amounts of polyphenols are found in the bloodstream, and then mostly as metabolites. The major aim of my doctorate work has been the development of “pro-drugs”, resistant to metabolism during absorption and capable of regenerating the natural compound thanks to the action of ubiquitous enzymes. Resveratrol was chosen as model polyphenol. The project is carried out in collaboration with a group of organic chemists who synthesise the compounds and also contribute analytical know-how. Since polyphenols generally have a low solubility in water, and solubility is a key factor contributing to the bioavailability of a compound, a first resveratrol derivative was synthesised in which succinyl linkers connected resveratrol hydroxyls on one side and glucose residues on the other via carboxyester bonds. Pharmacokinetic studies with this compound showed that the levels and the composition of the metabolite mix in the bloodstream were the same as those obtained using resveratrol itself. This suggested that the compound was hydrolysed to resveratrol in the gastro-intestinal tract, before absorption. The carboxyester bond system thus turned out to be too labile in vivo, and therefore of limited usefulness. Other bond systems, such as the ether and sulfonate linkages, proved on the contrary to be too stable We therefore turned to other functionalities. In one approach the acetal bond system was used to link protective/solubilising groups to resveratrol hydroxyls. This type of protecting group is hydrolysed under acid conditions, but turned out to be rather too stable for use in vivo. Ex vivo and in vivo experiments with a series of acetal derivatives bearing short oligo-ethylene glycol chains however allowed us to evaluate and appreciate the positive effect this type of substituents can have on the absorption process. In the search for a protective functionality with ideal stability characteristics, we then turned to yet another, more labile, bond type, which cannot be specified here. To confer water solubility, polyhydroxylated moieties or PEG chains were introduced via this bond system. The work has so far led to satisfactory levels of absorption with two regioisomeric mono-substituted derivatives: uM levels of resveratrol-containing molecules were measured in blood samples, persisting for hours. However, the two free hydroxyl groups in these compounds are targets for glucuronosyltransferases, which largely modify them before the regeneration of resveratrol can be completed. A new approach has now been adopted, incorporating the positive aspects which have emerged from the investigation of acetal derivatives. In these new compounds short oligo-ethyleneglycol chains are linked to all three hydroxyl groups of resveratrol to improve absorption while offering protection. These constructs may be expected to be well absorbed (depending on chain length) and to hydrolyse with suitable kinetics. Only preliminary results with one compound are available at the time this thesis is submitted. During my doctorate I had the opportunity to spend a six-month period in the laboratory of prof. E. Mervaala at the Institute of Biomedicine of the University of Helsinki, Finland. There I performed a preliminary study on the possible positive effects of resveratrol and caloric restriction against sunitinib-induced cardiotoxicity and renal damage in spontaneously hypertensive rats, using normotensive WKY rats as control. Sunitinib is a tyrosine kinase inhibitor (TKI). The results did not reveal statistically significative differences between control and treated rats. Further experiments will be needed before a definite conclusion can be reached. Finally, it should be mentioned that in a side project I participated in studies on the metabolism of polyphenols by cultured cells. Work with monolayers of colonic Caco-2 cells revealed a remarkable heterogeneity in the expression of Phase II metabolism enzymes (sulfo- and glucuronosyl-transferases) within the same cell line. It was however possible to regenerate a uniform activity in the different populations by cultivating the cells with low concentrations of a xenobiotic compound (in our case quercetin).
I polifenoli vegetali sono una vasta famiglia di composti naturali presenti in molti cibi e bevande. Molti di loro possiedono notevoli proprietà biologiche. Il resveratrolo per esempio, può aiutare a prevenire le malattie cardiovascolari, perchè è in grado di abbassare la pressione sanguigna, ridurre la perossidazione lipidica l’aggregazione piastrinica. Inoltre, il resveratrolo ha proprietà antiossidanti, anti infiammatorie e anti aterosclerotiche, risultanti nella protezione del sistema cardiovascolare, nel miglioramento del declino cognitivo legato all’età e nelle prevenzione e terapia del cancro. Questi potenziali effetti terapeutici trovano però un ostacolo nella scarsa biodisponibilità di questo composto e dei polifenoli in generale. Come risultato di un basso livello di assorbimento e di rapido metabolismo nelle cellule intestinali ed epatiche, nel sangue vengono ritrovate solo piccole quantità di polifenoli, e principalmente sotto forma di metaboliti. Lo scopo del mio progetto di dottorato è lo sviluppo di prodrugs di resveratrolo, il nostro polifenolo modello, resistenti al metabolismo durante l’assorbimento intestinale capaci di rigenerare il composto naturale grazie all’azione di enzimi ubiquitari. Il progetto è avvenuto in collaborazione con un gruppo di chimici organici che hanno sintetizzato i composti utilizzati in questa tesi. Dato che i polifenoli generalmente sono poco solubili in acqua, e la solubilità è un fattore determinante per la biodisponibilità di un composto, un primo precursore di resveratrolo è stato ottenuto funzionalizzando gli ossidrili con gruppi glucosio, attraverso un linker succinico (RGS); studi di farmacocinetica con questo composto mostrano che i livelli e la composizione dei metaboliti in circolo sono però del tutto analoghi a quelli ottenuti somministrando resveratrolo; questo suggerisce un’idrolisi del derivato a resveratrolo nel tratto intestinale, prima dell’assorbimento. Quindi, l’utilità del legame carbossiestereo in vivo è limitata. Sono stati successivamente sintetizzati altri precursori del resveratrolo, con un legame acetalico che lega gruppi protettivi/solubilizzanti agli ossidrili. Il legame acetalico è caratterizato da una bassa polarità e da uno scarso ingombro sterico, e si prevede quindi che favorisca il passaggio attraverso le bio-membrane. È suscettibile all’idrolisi in acido ma è comunque ancora troppo stabile per l’uso in vivo. Esperimenti ex vivo ed in vivo, con una serie di derivati acetalici recanti corte catene di oligo-etilene glicole utilizzando segmenti d’intestino, hanno permesso di determinare che la lunghezza della catena del gruppo solubilizzante influenza positivamente l’assorbimento. Alla ricerca di funzionalità protettive con ideali caratteristiche di stabilità, si è quindi passati ad un altro tipo di legame, più labile, che non può essere specificato qui. Tramite questo legame, allo scopo di conferire solubilità, sono state introdotte porzioni poliidrossilate o catene di PEG. Questa strategia ha portato a livelli di assorbimento soddisfacenti con due derivati (regioisomeri) monosostituiti: concentrazioni dell’ordine del uM di derivati del resveratrolo si ritrovano nel sangue, persistenti per ore. Tuttavia, i due idrossili liberi di questi composti sono substrati per le glucuronosiltrasferasi, e questa modificazione avviene prima che la rigenerazione di resveratrolo sia completa. Un nuovo approccio è stato ora adottato, incorporando gli aspetti positivi che sono emersi dagli esperimenti condotti con i derivati acetalici. In questi nuovi composti corte catene di oligo-etileneglicole sono legate ai tre idrossili del resveratrolo per aumentare l’assorbimento e nel contempo fornire protezione. Questi nuovi derivati dovrebbero essere ben assorbiti (in funzione della lunghezza della catena) e con un’adatta cinetica di idrolisi. Al momento della pubblicazione di questa tesi sono disponibili solo risultati preliminari. Durante il mio corso di dottorato ho avuto l’opportunità di trascorrere un periodo di sei mesi presso il gruppo di ricerca del Prof. Mervaala’s all’Università di Helsinki, dove ho condotto uno studio sui possibili effetti positivi del resveratrolo e della restrizione calorica sulla cardiotossicità e il danno renale indotti dal sunitinib in ratti sponteaneamente ipertesi, usando ratti normotesi come controllo. Il sunitinib è un inibitore delle tirosin-chinasi (TKI). I risultati preliminari non hanno permesso di evidenziare differenze statisticamente significative fra i controlli e i ratti trattati. Per trarre conclusioni maggiormente significative, sarà necessario condurre ulteriori esperimenti. Per finire, in durante lo stadio iniziale del progetto ho partecipato ad uno studio sul metabolismo di polifenoli in cellule in cultura. Gli studi di assorbimento/metabolismo con monostrati di cellule intestinali Caco-2 hanno messo in luce l’esistenza di eterogeneità nell’espressione degli enzimi metabolici di Fase II (solfo- e glucuronosil-trasferasi) all’interno della stessa linea cellulare. È comunque possibile uniformare nuovamente popolazioni con diversa attività metabolica coltivando le cellule in presenza di concentrazioni minime di xenobiotico (nel nostro caso quercetina).
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Paulo, Luísa Alexandra Serrano. "Determinação dos teores de resveratrol em vinhos tintos com denominação de origem controlada Beira Interior e avaliação das suas propriedades antimicrobianas". Doctoral thesis, Universidade da Beira Interior, 2011. http://hdl.handle.net/10400.6/1004.

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Reconhece-se actualmente que o vinho tem propriedades benéficas no organismo humano, sendo constituído por compostos que exercem uma influência positiva no metabolismo dos indivíduos que o consomem com regularidade e moderação. O resveratrol (trans-3,4’,5-trihidroxiestilbeno) é uma fitoalexina que está presente em diversos alimentos e bebidas, em particular no vinho tinto. Das várias classes de polifenóis existentes no vinho, o resveratrol (estilbeno) é um dos compostos mais estudados do ponto de vista de importância biológica, devido aos potenciais efeitos benéficos para a saúde humana. Na primeira parte deste trabalho foi desenvolvido e validado um método analítico sensível, com vista a determinar, quantitativamente, as concentrações de resveratrol em amostras de vinhos tintos portugueses, utilizando a extracção em fase sólida (SPE) e a cromatografia líquida de alta eficiência acoplada a um detector de díodos (HPLC-DAD). Na segunda parte, foram implementadas técnicas, tais como, o método de difusão em disco e o método da microdiluição, que permitiram avaliar a actividade antimicrobiana do resveratrol em diversos microrganismos, nomeadamente bactérias Gram-positivas (Bacillus cereus, Staphylococcus aureus e Enterococcus faecalis) e Gram-negativas (Escherichia coli, Klebsiella pnemoniae, Salmonella typhimurium e Pseudomonas aeruginosa). O efeito do resveratrol em bactérias Gram-positivas foi também analisado, recorrendo-se às curvas de morte, de forma a tentar assim compreender se o resveratrol actua como um agente bactericida ou bacteriostático. Analisou-se, ainda, a acção do resveratrol em Bacillus cereus, recorrendo à microscopia e à citometria de fluxo, de forma a tentar compreender o mecanismo de acção deste composto. Finalmente, foi também avaliada a actividade antimicrobiana do resveratrol em diferentes estirpes de Helicobacter pylori, utilizando o método da difusão em disco e o método da diluição em agar. Para além disso, verificou-se a hipótese do resveratrol e amostras de vinho tinto (devidamente quantificadas na primeira parte deste trabalho) inibirem a actividade da urease de H. pylori, considerada um dos principais factores de virulência deste microrganismo. Complementou-se, ainda, o estudo analisando cineticamente a actividade da urease na presença do resveratrol. O método analítico foi validado de acordo com normas internacionalmente aceites quanto a: especificidade, linearidade, limites de detecção (LOD) e de quantificação (LOQ), precisão, exactidão, estabilidade e eficiência de extracção. Verificou-se ainda a aplicabilidade do método, analisando 186 amostras de vinhos tintos comerciais, provenientes de diferentes regiões, castas e anos. Os resultados obtidos demonstraram que os níveis de trans-resveratrol nos vinhos tintos, variaram entre 0,05 e 10,9 μg/mL, enquanto que as concentração de cis-resveratrol variaram entre 0,04 e 8,71 μg/mL. No que diz respeito à actividade antimicrobiana do resveratrol, verificou-se que este composto possui actividade contra todas as bactérias Gram-positivas em estudo. Os resultados demonstraram que o resveratrol tem um efeito bacteriostático que afecta o crescimento da célula bacteriana em todas as estirpes testadas. Quanto ao mecanismo de acção do resveratrol, os resultados obtidos sugerem que o crescimento celular do Bacillus cereus foi inibido, o que por sua vez terá levado à paragem da divisão celular. Na última parte deste trabalho, confirmou-se a actividade antibacteriana do resveratrol em diferentes estirpes de Helicobacter pylori. Para além disso, quer o resveratrol, quer os vinhos tintos analisados demonstraram um efeito inibitório na actividade da urease de Helicobacter pylori. A análise cinética revelou que o resveratrol é um inibidor da urease não competitivo e reversível. O presente trabalho contribuiu por um lado, para o melhor conhecimento do teor de resveratrol nos vinhos portugueses, e por outro demonstrou o potencial do resveratrol como agente antibacteriano, podendo no futuro ter potenciais aplicações tanto na conservação dos alimentos como na terapia clínica.
It is now recognized that wine has beneficial properties for the human health, since it is constituted by compounds that exert a positive influence on the individuals’ metabolism, provided that the consumption is moderate. The phytoalexin resveratrol (3,4’,5-trihydroxistilbene) is commonly found in foodstuffs and drinks, particularly in red wine. From the various classes of polyphenols presented in wine, resveratrol (stilbene) is one of the most studied from the viewpoint of biological importance, due to the possible beneficial effects on the human health. In the first part of this work it was developed and validated a sensitive analytical method for the quantitative analysis of resveratrol in portuguese red wines, using solid phase extraction (SPE) and liquid chromatography coupled with diode array detector (HPLC-DAD). In the second part the antimicrobial activity of the compound was evaluated by means of different techniques, such as the disc diffusion and microdilution methods, and the studied microorganisms included Gram-positive (Bacillus cereus, Staphylococcus aureus and Enterococcus faecalis) and Gram-negative (Escherichia coli, Klebsiella pneumoniae, Salmonella typhimurium and Pseudomonas aeruginosa) bacteria. We also analyzed the effect of resveratrol on Gram-positive organisms using time-kill assays, in order to understand whether resveratrol acts as a bactericide or bacteriostatic. In order to understand the mechanism of action of this compound, its action against Bacillus cereus was analysed by microscopy and flow cytometry. Finally, the antimicrobial activity of resveratrol against different strains of Helicobacter pylori was evaluated using both the disk diffusion and agar dilution methods. In addition, we verified the ability of resveratrol and red wine samples (properly quantified in the first part of this work) to inhibit the urease activity of H. pylori, since this is considered a major virulence factor of this microorganism. Moreover, we complemented the study analyzing kinetically urease activity in the presence of resveratrol. The analytical method was fully validated according to internationally accepted guidelines, regarding specificity, linearity, limits of detection (LOD) and quantification (LOQ), precision, accuracy, stability and extraction efficiency. Once validated, the methodology was applied to 186 commercial red wine samples from different regions, grape varieties and vintage. The results showed that the content of trans-resveratrol in red wines ranged from 0.05 to 10.9 µg/mL, while the concentration of cis-resveratrol ranged from 0.04 to 8.71 µg/mL. Regarding the antimicrobial activity of resveratrol, we found that this compound has activity against all tested Gram-positive bacteria. The results demonstrated that resveratrol has a bacteriostatic effect which affects bacterial cell growth in all tested strains. As regards the mechanism of action of resveratrol, the results suggest that cell growth of Bacillus cereus was inhibited, which may in turn stop cell division. In the last part of this work, we confirmed the antibacterial activity of resveratrol against different strains of Helicobacter pylori. Furthermore, both resveratrol and red wines showed an inhibitory effect on urease activity of Helicobacter pylori. The kinetic analysis revealed that resveratrol is a non-competitive and reversible inhibitor of urease. The present work contributed to the best knowledge of portuguese wines regarding the levels of resveratrol, and demonstrated the possible use of this compound as an antibacterial agent, and may in future have potential applications for both food preservation and clinical therapy.
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Moreno, Carolina dos Santos. "Estudo do efeito radioprotetor do resveratrol". Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-06112009-100431/.

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Resveratrol (3,4,5-trihidroxiestilbeno), um polifenol pertencente ao grupo de compostos denominados fitoalexinas, é sintetizado por uma ampla variedade de plantas, tais como as videiras, em resposta a infecções fúngicas e a exposição à radiação UV. Nos vinhos este composto está presente em elevadas concentrações, sendo considerado um dos constituintes com maior potencial antioxidante. Esta elevada capacidade de absorver os radicais livres presentes em diversos processos biológicos permite ao resveratrol previnir doenças cardiovasculares e diversos tipos de câncer. O principal objetivo do presente estudo foi determinar in vitro o efeito radioprotetor do resveratrol em cultura celular com auxílio dos testes de citotoxicidade do resveratrol (IC50%) e da dose letal 50% da radiação gama (DL50). Os estudos in vitro do nível de toxicidade do resveratrol, verificado pelo ensaio de citotoxicidade utilizando-se o método de incorporação do vermelho neutro, e da determinação da dose letal 50% (DL50) da radiação gama, oriunda de uma fonte de Cobalto-60 (Co-60), foram realizados em cultura de células da linhagem NCTC Clone 929 da ATCC. O IC50% do resveratrol foi de aproximadamente 50 M/L. A DL50 da radiação gama apresentou um valor de aproximadamente 354 Gy. Baseando-se nestes resultados biológicos foram realizados estudos do efeito radioprotetor do resveratrol nas mesmas condições experimentais, constatando-se que o resveratrol nas concentrações entre 12,5 M/L e 25 M/L apresentou um efeito radioprotetor mais acentuado.
Resveratrol (3,4,5 trihydroxystilbene), a phenolic phytoalexin occurring naturally in a wide variety of plants, such as grapevines, in response to injury as fungal infections and exposure to ultraviolet light. In the wines this compound is present at high levels and is considered one of the higest antioxidant constituents. This high capacity to scavenge the free radicals generated by several biologic processes by resveratrol can provide a prevention of human cardiovascular diseases and several types of cancer. The main objective of this study was to determine the in vitro radioprotective effect of resveratrol in cell culture with the aid of the tests of cytotoxicity of resveratrol (IC50%) and lethal dose 50% of gamma radiation (LD50). Studies of the level of resveratrol toxicity, found by cytotoxicity test performed by neutral red uptake assay, and lethal dose 50% (LD50) of gamma radiation from source of Cobalt-60 (Co-60) was performed in cell culture NCTC Clone 929 from ATCC. The IC50% of resveratrol was about 50M/L. The DL50 of gamma radiation showed a value of about 354Gy. On the basis of these biological results, it was performed studies of radioprotective effect of resveratrol on the same experimental conditions, verifying that the resveratrol in concentrations between 12.5M/L and 25M/L showed a more pronounced radioprotective effect.
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Lieben, Louis Xavier. "Resveratrol mediated cardioprotection in obese rats". Journal of Nutritional Biochemistry, 2011. http://hdl.handle.net/1993/29506.

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Obesity is a major epidemic and an independent risk factor for heart disease. Food derived compounds such as resveratrol has been reported to have strong medicinal properties and shown potential in preventing and reversing heart diseases. This study investigated the cardioprotective properties of resveratrol in an animal model of diet induced obesity and possible cellular mechanisms. Obese prone (OP) and obese resistant (OR) rats were fed with high fat diet while, sprague dawley (SD) rats that served as control were fed with normal lab chow for a total of 17 weeks. During the last 5 weeks of study, treatment group received resveratrol daily by oral gavage at a dosage of 2.5 mg/kg body weight. Treatment with resveratrol significantly improved cardiac isovolumic relaxation time (IVRT), thiobarbituric acid reactive substance (TBARS), tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), triglycerides, glucose, low density lipoprotein and increased insulin in OP rats and TNF-α, glucose and leptin in OR rats. Cardiac calcium handling proteins such as sarcoendoplasmic reticulum Ca2+-ATPase2a (SERCA2a), phospholamban (PLB) and phosphorylated PLBthr17 and PLBser16 were unchanged in all the groups. Excess circulating lipids cause cellular dysfunction in major organs. Adult rat cardiomyocytes were incubated for 24 hours with different doses (10, 100 and 200µM) of palmitic acid (PA). One group cardiomyocytes were pretreated with resveratrol for 45minutes prior to addition of PA. Incubation with 200µM PA significantly increased the number of round shaped cardiomyocytes and apoptosis and resveratrol treatment prevented these changes. Cardiomyocytes contractility measurement showed 200µM PA resulted in reduced rate of relaxation and resveratrol prevented this reduction. Western blot analysis showed that the PA induced a 17% decrease in SERCA2a expression and SERCA2A:PLB ratio was preserved with resveratrol treatment. The change in SERCA2a with PA and resveratrol exposure was statistically not significant. In conclusion, resveratrol treatment reversed cardiac abnormalities in OP rats, but not in OR rats. Resveratrol treatment prevented PA induced contractile abnormality in adult cardiomyocytes. Importantly, this study showed that resveratrol can act directly on cardiomyocytes and protect against damage from exposure to high levels of lipids.
February 2015
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MORENO, CAROLINA dos S. "Estudo do efeito radioprotetor do resveratrol". reponame:Repositório Institucional do IPEN, 2009. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9440.

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Dissertacao (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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Libri sul tema "Resveratrol"

1

England) International Conference of Resveratrol and Health (2nd 2012 Leicester. Resveratrol and health. A cura di Brown, Karen (Pharmaceutical chemist), editor, Vang Ole editor e New York Academy of Sciences. Hoboken, N.J: Published on behalf of the New York Academy of Sciences by Wiley Subscription Services, 2013.

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Das, Dipak Kumar, e Ole Vang. Resveratrol and health. Boston, Mass: published by Blackwell Publishing on behalf of the New York Academy of Sciences, 2011.

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1950-, Aggarwal Bharat B., e Shishodia Shishir, a cura di. Resveratrol in health and disease. Boca Raton: CRC/Taylor & Francis, 2006.

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Delmas, Dominique. Resveratrol: Sources, production and health benefits. Hauppauge, N.Y: Nova Science Publisher's, 2012.

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Maroon, Joseph C. The longevity factor: How resveratrol and red wine activate your longevity genes. New York: Atria Books, 2009.

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Geisler, Beth. Resveratrol: Unleashing the benefits of red wine. Summertown, Tenn: Healthy Living Publications, 2011.

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Geisler, Beth, e Beth Geisler. Resveratrol: Unleashing the benefits of red wine. Summertown, Tenn: Healthy Living Publications, 2011.

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Studies towards Selective Synthesis of Resveratrol-based Oligomeric Natural Products. [New York, N.Y.?]: [publisher not identified], 2011.

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A cardiologist's guide to-- anti-aging, antoxidants & resveratrol: How red wine extract, resveratrol and super antioxidants are conquering heart disease, cancer, diabetes, Alzheimer's, obesity, old age. Boca Raton, FL: Renaissance Health Education, 2007.

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Aristotle, Liontas. Biological, biochemical and molecular anti-tumour mechanisms of curcumin and resveratrol in neuroblastoma. Ottawa: National Library of Canada, 2003.

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Capitoli di libri sul tema "Resveratrol"

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Ghidoni, Riccardo. "Resveratrol". In Encyclopedia of Cancer, 1–4. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27841-9_5064-2.

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Ghidoni, Riccardo. "Resveratrol". In Encyclopedia of Cancer, 4033–36. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-46875-3_5064.

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Ghidoni, Riccardo. "Resveratrol". In Encyclopedia of Cancer, 3267–69. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_5064.

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Martinez, José L., Onder Yumrutas, Maite Rodriguez, Miguel Rios, Rao Zahid Abbas, Luisauris Jaimes e Ali Parlar. "Resveratrol". In Ethnobotany, 44–64. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003323969-2.

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Förstermann, Ulrich, e Huige Li. "Resveratrol und Gesundheit". In Kulturgut Rebe und Wein, 199–206. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-8274-2887-5_18.

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McMurtrey, Kenneth D. "Resveratrol in Wine". In ACS Symposium Series, 44–55. Washington, DC: American Chemical Society, 1997. http://dx.doi.org/10.1021/bk-1997-0661.ch005.

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Rashid, Summya. "Chemoprevention by Resveratrol". In Cancer and Chemoprevention: An Overview, 109–14. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-2579-2_16.

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Wang, Jian, Yaping Yang e Yajun Yan. "Bioproduction of Resveratrol". In Biotechnology of Natural Products, 61–79. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-67903-7_3.

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Salas, Mayela Govea, Leticia A. Menchaca Castro, Rafael G. Aráujo, Sujey A. Niño Herrera, Anna Iliná, Roberto Arredondo Valdés, María del Carmen Rodríguez Salazar, Mónica L. Chávez González, E. Patricia Segura Ceniceros e Cristóbal N. Aguilar González. "Resveratrol and Immunomodulation". In Nutraceuticals and Functional Foods in Immunomodulators, 213–51. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-2507-8_9.

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Ibrahim, Gehad G., e Yunjun Yan. "Microbial Production of Resveratrol". In Microbial Production of Food Bioactive Compounds, 1–34. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-81403-8_23-1.

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Atti di convegni sul tema "Resveratrol"

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Tosatti, Jéssica, Adriana Fontes, Paulo Caramelli e Karina Gomes. "EFFECTS OF RESVERATROL SUPPLEMENTATION ON THE COGNITIVE FUNCTION OF PATIENTS WITH ALZHEIMER’S DISEASE: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS". In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda026.

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Background: Alzheimer’s disease (AD) is characterized by a deposition of β-amyloid peptide and the neurofibrillary tangles of tau protein. Resveratrol is a neuroprotective agent, acting in the prevention of redox impairment, and could reduce neuronal damage in patients with AD. Objectives: Systematic review and meta-analysis about the effects of resveratrol supplementation on cognitive and functional performance in patients with AD. Methods: Databases were searched for primary studies that reported cognitive and functional performance based on ADAS-cog, ADCS-ADL or MMSE instruments in AD patients treated with resveratrol. Primary studies published up to May 2021 and without language and publication date restrictions were included. The measure of effect of the meta-analysis was presented as weighted mean difference (WMD). decrease in ADAS-cog scores [WMD: -3.69 points], and significant increases in ADCS-ADL [WMD: 5.65 points] and MMSE scores [WMD: 2.03 points] in the resveratrol intervention group, when compared to the placebo group. Conclusions: Resveratrol supplementation may result in improving cognitive and functional performance in AD patients.
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Diniz, Ítalo Felipe da Silva, e Diogo Leonardo Santos Silva. "EFEITOS ANTICÂNCER DO RESVERATROL". In I CONGRESSO BRASILEIRO INTEGRADO EM SAÚDE PÚBLICA E COLETIVA (I CONBRAISPUC). Literacia Cientifica Editora & Cursos, 2023. http://dx.doi.org/10.53524/lit.edt.978-65-84528-21-5/97.

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José, V. M., J. T. Guillen, M. A. García e N. E. Franco. "Efecto del tratamiento con tamoxifeno y resveratrol en la locomoción de la rata después de daño cerebral penetrante en la corteza motora primaria". In XLI Congreso Nacional de Ingeniería Biomédica. Sociedad Mexicana de Ingeniería Biomédica, 2018. http://dx.doi.org/10.24254/cnib.18.77.

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Los traumas por lesión cerebral penetrante pueden variar desde un daño mínimo, generar defectos cognitivos y motores o incluso causar la muerte, lo que nos lleva a plantear un posible tratamiento. Entre estas alternativas encontramos al tamoxifeno y resveratrol que tienen propiedades antioxidantes, antiinflamatorias anti-apoptóticas y anti-mutagénicas promoviendo así un posible efecto neuroprotector [1-3]. Sin embargo, el resveratrol tiene baja estabilidad química y rápido metabolismo. Esto hace necesario plantear una estrategia para estabilizar la molécula y facilitar su paso por la barrera hemato-encefálica, obteniendo efectos terapéuticos más efectivos. Planteamos una estrategia de tratamiento con tamoxifeno durante el periodo agudo del daño (0-2 post-lesión) y con resveratrol en la fase crónica (3-21 post-lesión), utilizando micropartículas lipídicas como vehículo de administración para el resveratrol y evaluando el efecto del tratamiento conjunto en la actividad locomotora después del daño en corteza motora mediante análisis de la locomoción a los 7, 14, 21 y 28 días post-lesión.
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Agbadua, Orinamhe Godwin, Norbert Kúsz, Tamás Gáti, Gábor Tóth e Attila Hunyadi. "Biomimetic oxidized resveratrol metabolite mixtures". In Fiatal Gyógynövénykutatók Fóruma. Szeged: Magyar Gyógyszerésztudományi Társaság Gyógynövény Szakosztálya, 2022. http://dx.doi.org/10.14232/fgykf.2022.a10.

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Oliveira, Analice Barbosa Santos De. "O RESVERATROL: UM POLIFENOL NO TRATAMENTO DA DEPRESSÃO". In III Congresso Brasileiro de Ciências Farmacêuticas On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/conbracif/65.

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Introdução: O Resveratrol (3,4’, 5-trihidroxiestilbene) é um polifenol abundante na casca e nas sementes da uva e inclusive no vinho, frutas e amendoim e está associado a uma melhora na saúde geral do indivíduo e sabe-se que ele está envolvido na redução de danos neuronais e apoptose e ainda possui uma variedade de bioatividades incluindo propriedades anti doenças cardiovasculares, anticancerígenas, antioxidantes e anti-inflamatórias. É encontrado em uvas vermelhas, vinho tinto, amendoim e outras fontes vegetais. Objetivo: Este trabalho tem por objetivo revisar a literatura existente a respeito do poder do resveratrol no tratamento da depressão. Material e métodos: Para isto, utilizou-se da plataforma Pubmed a partir dos descritores: “polyphenols and depression”, encontrando 164 resultados referentes aos anos de 1996 a 2022 e selecionando 13 estudos. Resultados: Quanto aos resultados, constatou-se que os polifenois podem exercer efeitos positivos na saúde do cérebro no envelhecimento, enfatizando os efeitos nas doenças que mais comumente afetam o cérebro durante o envelhecimento que é a doença de Parkinson, Doença de Alzheimer, demência e a depressão e ainda exercendo papel com diversas propriedades como o estresse oxidativo, atividade contra a glicação, inflamação, neurodegeneração. Percebeu-se que os polifenois, destacando entre eles o resveratrol, micronutrientes não essenciais, afetam várias funções fisiológicas e bioquímicas no organismo no transtorno depressivo. Conclusão: Entende-se que a depressão está associada à desregulação imune induzida pelo estresse e níveis reduzidos de fator neurotrófico derivado do cérebro em regiões cerebrais sensíveis associadas à depressão com níveis elevados de citocinas pró-inflamatórias e o resveratrol pode ser um promissor antidepressivo natural com menos reações adversas.
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Dhayalan, Sreenivasan, Sathish Raam Ravichandran, Chitra Devi Venkatachalam e Mothil Sengottian. "Effective extraction of resveratrol through hydrotropy". In 3RD NATIONAL CONFERENCE ON CURRENT AND EMERGING PROCESS TECHNOLOGIES – CONCEPT 2020. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0011054.

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Agbadua, Orinamhe Godwin. "Studies on oxidized resveratrol metabolite mixtures". In 2nd Symposium of Young Researchers on Pharmacognosy. Szeged: Department of Pharmacognosy, University of Szeged, Faculty of Pharmacy, 2021. http://dx.doi.org/10.14232/syrpharmacognosy.2021.a2.

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Goldhahn, Katrin, Burkhard Kloesch, Farid Aldawsari, Carlos Velazques-Martinez, Klaus Schmetterer e Guenter Steiner. "06.10 Effects of resveratrol and a resveratrol-salicylate hybrid molecule on activation of human cd4+t- cells". In 37th European Workshop for Rheumatology Research 2–4 March 2017 Athens, Greece. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2016-211053.10.

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Zhou, Min, e Xi Chen. "Preparation and Biological Availability of Resveratrol Nanoparticles". In 2016 International Conference on Smart City and Systems Engineering (ICSCSE). IEEE, 2016. http://dx.doi.org/10.1109/icscse.2016.0169.

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Bombelli, Cecilia, Livia Pagano, Stefano Aiello, Foteini Gkartziou, Beatrice Simonis, Francesca Ceccacci, Simona Sennato et al. "Resveratrol-Loaded Glycosylated Liposomes for Targeting Bacteria". In ECMC 2022. Basel Switzerland: MDPI, 2022. http://dx.doi.org/10.3390/ecmc2022-13158.

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Rapporti di organizzazioni sul tema "Resveratrol"

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Wu, Joseph M. Cellular Targets of Dietary Polyphenol Resveratrol. Fort Belvoir, VA: Defense Technical Information Center, settembre 2006. http://dx.doi.org/10.21236/ada462814.

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Whitsett, Timothy G. Chemoprevention Against Breast Cancer with Genistein and Resveratrol. Fort Belvoir, VA: Defense Technical Information Center, marzo 2008. http://dx.doi.org/10.21236/ada483461.

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Whitsett Jr., Timothy G., e Coral A. Lamartiniere. Chemoprevention Against Breast Cancer with Genistein and Resveratrol. Fort Belvoir, VA: Defense Technical Information Center, marzo 2007. http://dx.doi.org/10.21236/ada469973.

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Singh, Chandra K., e Nihal Ahmad. Combination of Resveratrol and Zinc for Prostate Cancer Management. Fort Belvoir, VA: Defense Technical Information Center, maggio 2013. http://dx.doi.org/10.21236/ada580255.

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Momchilova, Albena, Galya Staneva, Rumiana Tzoneva, Ralica Scrobanska, Georgi Georgiev, Mariana Hadzhilazova, Liliana Maslenkova e Roumen Pankov. Resveratrol Affects Sphingomyelin and Cholesterol in Three-dimensional Fibroblast Cultures. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, aprile 2019. http://dx.doi.org/10.7546/crabs.2019.04.07.

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Dharmawardhane, Suranganie. Estrogen and the Dietary Phytoestrogen Resveratrol as Regulators of the Rho GTPase Rac in Breast Cancer Metastasis. Fort Belvoir, VA: Defense Technical Information Center, settembre 2011. http://dx.doi.org/10.21236/ada554793.

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Dharmawardhane, Suranganie. Estrogen and the Dietary Phytoestrogen Resveratrol as Regulators of the Rho GTPase Rac in Breast Cancer Research. Fort Belvoir, VA: Defense Technical Information Center, giugno 2009. http://dx.doi.org/10.21236/ada625286.

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Wu, Lihua, Ling Wu, Yu Liu, Ting Jiang, Ju Yang e Mingquan Li. Can resveratrol protect against renal ischemia/reperfusion injury? A systematic review and meta-analysis of preclinical studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, aprile 2021. http://dx.doi.org/10.37766/inplasy2021.4.0102.

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He, Miao, Sen Wang, Jing You, Jing Shi, Yanbing Yin e Weirong Li. Neuroprotective effects of resveratrol against cerebral ischemia/reperfusion injury through anti-oxidant and anti-inflammatory mechanisms：A Systematic Review and Meta-Analysis in Rodents. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, agosto 2022. http://dx.doi.org/10.37766/inplasy2022.8.0059.

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Fait, Aaron, Grant Cramer e Avichai Perl. Towards improved grape nutrition and defense: The regulation of stilbene metabolism under drought. United States Department of Agriculture, maggio 2014. http://dx.doi.org/10.32747/2014.7594398.bard.

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The goals of the present research proposal were to elucidate the physiological and molecular basis of the regulation of stilbene metabolism in grape, against the background of (i) grape metabolic network behavior in response to drought and of (ii) varietal diversity. The specific objectives included the study of the physiology of the response of different grape cultivars to continuous WD; the characterization of the differences and commonalities of gene network topology associated with WD in berry skin across varieties; the study of the metabolic response of developing berries to continuous WD with specific attention to the stilbene compounds; the integration analysis of the omics data generated; the study of isolated drought-associated stress factors on the regulation of stilbene biosynthesis in plantaand in vitro. Background to the topic Grape quality has a complex relationship with water input. Regulated water deficit (WD) is known to improve wine grapes by reducing the vine growth (without affecting fruit yield) and boosting sugar content (Keller et al. 2008). On the other hand, irregular rainfall during the summer can lead to drought-associated damage of fruit developmental process and alter fruit metabolism (Downey et al., 2006; Tarara et al., 2008; Chalmers et al., 792). In areas undergoing desertification, WD is associated with high temperatures. This WD/high temperature synergism can limit the areas of grape cultivation and can damage yields and fruit quality. Grapes and wine are the major source of stilbenes in human nutrition, and multiple stilbene-derived compounds, including isomers, polymers and glycosylated forms, have also been characterized in grapes (Jeandet et al., 2002; Halls and Yu, 2008). Heterologous expression of stilbenesynthase (STS) in a variety of plants has led to an enhanced resistance to pathogens, but in others the association has not been proven (Kobayashi et al., 2000; Soleas et al., 1995). Tomato transgenic plants harboring a grape STS had increased levels of resveratrol, ascorbate, and glutathione at the expense of the anthocyanin pathways (Giovinazzo et al. 2005), further emphasizing the intermingled relation among secondary metabolic pathways. Stilbenes are are induced in green and fleshy parts of the berries by biotic and abiotic elicitors (Chong et al., 2009). As is the case for other classes of secondary metabolites, the biosynthesis of stilbenes is not very well understood, but it is known to be under tight spatial and temporal control, which limits the availability of these compounds from plant sources. Only very few studies have attempted to analyze the effects of different environmental components on stilbene accumulation (Jeandet et al., 1995; Martinez-Ortega et al., 2000). Targeted analyses have generally shown higher levels of resveratrol in the grape skin (induced), in seeded varieties, in varieties of wine grapes, and in dark-skinned varieties (Gatto et al., 2008; summarized by Bavaresco et al., 2009). Yet, the effect of the grape variety and the rootstock on stilbene metabolism has not yet been thoroughly investigated (Bavaresco et al., 2009). The study identified a link between vine hydraulic behavior and physiology of stress with the leaf metabolism, which the PIs believe can eventually lead to the modifications identified in the developing berries that interested the polyphenol metabolism and its regulation during development and under stress. Implications are discussed below.
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