Letteratura scientifica selezionata sul tema "Renal histology"
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Articoli di riviste sul tema "Renal histology":
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Spaliviero, Massimiliano, Kelly Lynn Stratton, Timothy F. Donahue, Banumathy Gowrishankar, Charles Ma, Jeremy C. Durack, Stephen Barnett Solomon, Jane Houldsworth e Jonathan A. Coleman. "Fluorescence in situ hybridization (FISH) and array-comparative genomic hybridization (a-CGH) from percutaneous needle biopsy compared to renal mass histology." Journal of Clinical Oncology 31, n. 6_suppl (20 febbraio 2013): 471. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.471.
Abstract (sommario):
471 Background: Image-guided percutaneous needle biopsies are increasingly utilized for the diagnosis of renal tumors. Histologic diagnosis of renal mass subtypes, including malignant clear cell (ccRCC), papillary (pRCC), chromophobe (chrRCC) renal cell carcinoma, and benign oncocytomas (OC) can be challenging due to the low cellularity and damaged architecture of needle biopsy specimens. However, each subtype exhibits unique genetic aberrations that can assist in histologic classification and potentially assist in guiding management decisions. We report our initial experience correlating renal mass histology to subtype-associated genomic alterations detected by FISH and a-CGH of percutaneous needle biopsy specimens. Methods: In an ongoing IRB-approved blinded study, 17 samples obtained from 15 patients with known renal masses were submitted to FISH (FReCaD) and targeted a-CGH (UroGenRA-Kidney). Specimens were classified using a subtype classification decision tree algorithm based on the presence/absence of genomic abnormalities. The results were compared to biopsy histology or surgical specimen when available. Results: Histology revealed ccRCC in 6 patients, pRCC in 4, OC in 2, Angiomyolipoma in 1, and unclassified type RCC in 2. In 6 of 9 cases FISH achieved a diagnosis, which correlated with histology in 4. FISH incorrectly classified as ccRCC two cases with pRCC on histology. A-CGH was diagnostic in 14 of 15 cases and correlated with histology in 13. In one case, a-CGH showed a genomic profile not consistent with ccRCC, pRCC, chrRCC, or OC according to the algorithm. Conclusions: The addition of genetic tumor tissue studies to complement histology from biopsy tissues may supplement or improve the accuracy of classification and biological characterization of renal tumor biopsies and influence treatment planning. In our initial experience, a-CGH showed better correlation with histology in subtype classification of malignant and benign renal masses than FISH. Prospective testing will be required to validate these results.
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Zajjari, Yassir, Taoufiq Aatif, Kawtar Hassani, Sanaa Benbria e Driss El Kabbaj. "Renal histology in diabetic patients". Saudi Journal of Medicine and Medical Sciences 7, n. 1 (2019): 22. http://dx.doi.org/10.4103/sjmms.sjmms_76_18.
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d'Ardenne, A. J., M. S. Dunnill, J. F. Thompson, D. McWhinnie, R. F. Wood e P. J. Morris. "Cyclosporin and renal graft histology." Journal of Clinical Pathology 39, n. 2 (1 febbraio 1986): 145–51. http://dx.doi.org/10.1136/jcp.39.2.145.
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Serón, Daniel, Dolores Burgos e Ángel Alonso. "Histology and proteinuria after renal transplantation". Transplantation Reviews 26, n. 1 (gennaio 2012): 20–26. http://dx.doi.org/10.1016/j.trre.2011.07.009.
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Malluche, H. H., M. C. Langub e M. C. Monier-Faugere. "Pathogenesis and histology of renal osteodystrophy". Osteoporosis International 7, S3 (maggio 1997): 184–87. http://dx.doi.org/10.1007/bf03194369.
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Rice-Stitt, Travis, Aida Valencia-Guerrero, Kristine M. Cornejo e Chin-Lee Wu. "Updates in Histologic Grading of Urologic Neoplasms". Archives of Pathology & Laboratory Medicine 144, n. 3 (1 marzo 2020): 335–43. http://dx.doi.org/10.5858/arpa.2019-0551-ra.
Abstract (sommario):
Context.— Tumor histology offers a composite view of the genetic, epigenetic, proteomic, and microenvironmental determinants of tumor biology. As a marker of tumor histology, histologic grading has persisted as a highly relevant factor in risk stratification and management of urologic neoplasms (ie, renal cell carcinoma, prostatic adenocarcinoma, and urothelial carcinoma). Ongoing research and consensus meetings have attempted to improve the accuracy, consistency, and biologic relevance of histologic grading, as well as provide guidance for many challenging scenarios. Objective.— To review the most recent updates to the grading system of urologic neoplasms, including those in the 2016 4th edition of the World Health Organization (WHO) Bluebook, with emphasis on issues encountered in routine practice. Data Sources.— Peer-reviewed publications and the 4th edition of the WHO Bluebook on the pathology and genetics of the urinary system and male genital organs. Conclusions.— This article summarizes the recently updated grading schemes for renal cell carcinoma, prostate adenocarcinomas, and bladder neoplasms of the genitourinary tract.
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&NA;. "Ciclosporin withdrawal improves renal histology and function?" Inpharma Weekly &NA;, n. 1449 (agosto 2004): 12. http://dx.doi.org/10.2165/00128413-200414490-00028.
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LEE, BENJAMIN R., JEFFREY A. CADEDDU, GYONGYI MOLNAR-NADASDY, DEBBIE ENRIQUEZ, TIBOR NADASDY, LOUIS R. KAVOUSSI e LLOYD E. RATNER. "Chronic Effect of Pneumoperitoneum on Renal Histology". Journal of Endourology 13, n. 4 (maggio 1999): 279–82. http://dx.doi.org/10.1089/end.1999.13.279.
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Van Loon, Elisabet, Evelyne Lerut e Maarten Naesens. "The time dependency of renal allograft histology". Transplant International 30, n. 11 (28 settembre 2017): 1081–91. http://dx.doi.org/10.1111/tri.13042.
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Gaber, L. W., L. W. Moore, L. Reed, W. Russell, R. Alloway, D. Hathaway, M. H. Shokouh-Amiri e A. O. Gaber. "Renal histology with varying FK506 blood levels". Transplantation Proceedings 29, n. 1-2 (febbraio 1997): 186. http://dx.doi.org/10.1016/s0041-1345(97)82525-0.
Tesi sul tema "Renal histology":
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Custodio, Marcelo Graziano. "Análise morfológica renal de ratas prenhes submetidas ao estresse". Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-11122006-102216/.
Abstract (sommario):
O presente trabalho avaliou os rins de ratas Wistar prenhes e não prenhes submetidas ao estresse e seus respectivos controles. O estresse crônico consistiu de estímulo sônico de 100 decibéis por trinta minutos, interrompido por noventa minutos, e superpopulação entre o sétimo e o décimo quarto dia de gestação e o estresse agudo foi representado pela imobilização durante trinta minutos, no décimo oitavo dia da prenhez ou período equivalente nas ratas não prenhes, dois dias antes do final do experimento. Todas as ratas foram sacrificadas no vigésimo dia do protocolo. Foram avaliados os rins de todas as ratas do estudo, assim como o peso das ratas no primeiro, sétimo, décimo quarto e vigésimo dia do experimento, a pressão arterial caudal no quinto e décimo oitavo dia de prenhez, ou período equivalente, e os pesos dos fetos e respectivas placentas. Não foram encontradas alterações à microscopia óptica nos rins das ratas submetidas ao estresse; entretanto foram observadas maiores medidas de pressão arterial caudal sistólica (154,4 ± 14,2 mmHg) e diastólica (89,0 ± 8,7 mmHg) no grupo prenhe estresse (p < 0,05) em relação ao grupo prenhe controle (129,1 ± 13,1 mmHg e 79,9 ± 18,1 mmHg, respectivamente) no décimo oitavo dia e menor peso dos fetos (2,54 ± 0,32g) e das placentas (0,53 ± 0,09 g) de ratas submetidas ao estresse crônico no vigésimo dia de prenhez (p < 0,001) quando comparados aos do grupo controle (2,95 ± 0,53g e 0,60 ± 0,08g, respectivamente). Desta maneira, o modelo analisado pode ser empregado para avaliar a restrição do crescimento intra-uterino de ratos causada pelo estresse crônico, provavelmente decorrente do aumento dos níveis pressóricos maternos durante a prenhezThis study evaluated the kidneys from pregnant and non-pregnant Wistar rats exposed to chronic stress and its respective control groups. The chronic stress consisted of noise exposure (30 minutes of 100-dB each two hours interval) and super-population between the 7th and 14th day and the acute stress of thirty minutes immobilization in the 18th of pregnancy two days before the end of the experiment. All the rats were killed in the 20th day of protocol. The kidneys were studied and also the weight of the rats in the 1st, 7th, 14th and 20th day, the caudal artery blood pressure in the 5th and 18th day, and the fetus and placentas weight. There were not seen any alteration using light microscopy in the kidney of rats submitted to stress; although it was observed a significant increase in systolic (154.4 ± 14.2 mmHg) and diastolic (89.0 ± 8.7 mmHg) caudal blood pressure in the 18th day in the pregnant stress group (p < 0.05) in relation to the control group (129.1 ± 13.1 mmHg and 79.9 ± 18.1 mmHg, respectively) and a decrease in fetal (2.54 ± 0.32g) and placenta (0.53 ± 0.09g) weight in the 20th day in the pregnant stress group (p < 0.001) in relation to the control group (2.95 ± 0.53g and 0.60 ± 0.08g, respectively). The analyzed model may be employed to evaluate the intrauterine growth restriction in rats, caused by chronic stress, probably induced by hypertension during the pregnancy
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Brant, Stephen. "Distribution of renal S100 proteins in physiological and pathological models". Thesis, University of East London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342101.
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White, S. J. "Anion transport in the renal proximal tubule of the rat". Thesis, University of Manchester, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376286.
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Poucher, S. M. "Changes in renal function from carotid baroreceptor and chemoreceptor stimulation in anaesthetised dogs". Thesis, University of Leeds, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355706.
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Oliveira, Paola Rosa de. "Caracterização morfo-histológica do segmento sexual renal e espermatogênese de Notomabuya frenata (Cope, 1862) e Aspronema dorsivittatum (Cope, 1862) (Squamata, Mabuyidae)". Universidade Federal de Juiz de Fora (UFJF), 2017. https://repositorio.ufjf.br/jspui/handle/ufjf/4818.
Abstract (sommario):
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Dentre os estudos sobre características reprodutivas de lagartos, muitos são realizados com espécies de regiões temperadas. Diferentes fatores podem influenciar no ciclo reprodutivo das espécies de lagartos neotropicais como umidade, temperatura e pluviosidade, sendo este último determinante em regiões tropicais. Estudos sobre a biologia reprodutiva de lagartos do gênero Mabuya revelaram características peculiares da reprodução e da história de vida; com isso pode ser considerado um táxon modelo para estudos sobre a evolução dos padrões reprodutivos em vertebrados. As espécies Notomabuya frenata e Aspronema dorsivittatum, apesar de apresentarem alguns aspectos reprodutivos conhecidos, muitas de suas características ainda são desconhecidas. Nesse contexto, o objetivo do presente estudo foi caracterizar morfohistologicamente o segmento sexual renal (SSR) e a espermatogênese de N. frenata e A. dorsivittatum. Os espécimes utilizados neste estudo foram coletados em uma área do bioma Cerrado no estado de Minas Gerais, Brasil. Os rins foram analisados através de microscopia de luz e eletrônica de varredura; e os testículos apenas com microscopia de luz. Ao analisar os rins, constatou-se a presença do SSR apenas em machos sexualmente maduros. O SSR se apresentou revestido por células colunares altas, com núcleo basal e a porção apical repleta de grânulos secretores; tais características morfo-histológicas observadas em ambas as espécies são similares as observadas em outros estudos com diferentes espécies de Squamata. Os testículos foram processados de acordo com técnicas de histologia convencional e analisados por microscopia de luz. Todos os espécimes machos adultos analisados estavam em período reprodutivo, pois apresentavam espermatozoides nos testículos e/ou epidídimos. O epitélio germinativo de ambas as espécies era composto por células germinativas e células de Sertoli, x apresentando um ciclo reprodutivo contínuo. O epidídimo das espécies estudadas apresentouse revestido por epitélio colunar simples, com células altas, núcleos basais e o lúmen completamente preenchido por espermatozoides. Os espécimes de N. frenata e A. dorsivittatum analisadas apresentaram o epitélio germinativo organizado de forma similar a outros Squamatas anteriormente estudados. Existem poucos estudos que abordem a descrição morfo-histológica do segmento sexual renal, células germinativas e espermatogênese de lagartos brasileiros. Dessa forma, o presente estudo acrescenta, não somente o conhecimento sobre a biologia reprodutiva nessas espécies, mas auxilia numa maior compreensão sobre estratégia e biologia reprodutivas em espécies vivíparas e neotropicais.
Among the studies on the reproductive characteristics of lizards, many are carried out with species of temperate regions. Different factors may influence the reproductive cycle of neotropical lizard species such as humidity, temperature and rainfall, being the latter determinant in tropical regions. Studies on the reproductive biology of lizards of the genus Mabuya revealed peculiar characteristics of the reproduction and the history of life; with this it can be considered a model taxon for studies on the evolution of the reproductive patterns in vertebrates. The species Notomabuya frenata and Aspronema dorsivittatum, although presenting some known reproductive aspects, many of its characteristics are still unknown. In this context, the objective of the present study was to characterize the morphologically the sexual segment of the kidney (SSK) and the spermatogenesis of N. frenata and A. dorsivittatum. The specimens used in this study were collected in an area of the Cerrado biome in the state of Minas Gerais, Brazil. The kidneys were analyzed by light microscopy and scanning electron microscopy; and the testis only with light microscopy. When analyzing the kidneys, the presence of SSK was only found in sexually mature males. The SSK was coated by high columnar cells with basal nucleus and the apical portion filled with secretory granules; Such morpho-histological characteristics observed in both species are similar to those observed in other studies with different Squamata species. The testes were processed according to standard histology techniques and analyzed by light microscopy. All the adult male specimens analyzed were in the reproductive period, as they had spermatozoa in the testis and / or epididymis. The germinal epithelium of both species was composed of germ cells and Sertoli cells, presenting a continuous reproductive cycle. The epididymis of the species studied was coated by simple xii columnar epithelium, with high cells, basal nucleus and the lumen completely filled by spermatozoa. The specimens of N. frenata and A. dorsivittatum analyzed presented the germinative epithelium organized in a similar way to other Squamata previously studied. There are few studies that address the morpho-histological description of the renal sexual segment, germ cells and spermatogenesis of Brazilian lizards. Thus, the present study not only adds knowledge about reproductive biology in these species, but also aids in a better understanding of reproductive strategy and biology in viviparous and neotropical species.
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Cavaglieri, Rita de Cássia. "Terapia com células-tronco na nefropatia crônica experimental: é possível bloquear a progressão da doença renal?" Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-19032010-125745/.
Abstract (sommario):
Células-tronco (CT) apresentam potencial terapêutico para a doença renal pela possibilidade de regeneração tecidual e recuperação funcional, possivelmente por efeitos parácrinos. Diversos trabalhos mostraram seu efeito renoprotetor em modelo de insuficiência renal aguda. No entanto, existem poucos trabalhos que avaliaram o efeito da CT em doença renal crônica. Neste contexto, a via de inoculação e o número das CT na região da lesão podem desempenhar um papel crucial. Assim, o transplante de CT pela via EV não parece ser o mais apropriado para prover CT em número expressivo no órgão alvo. Uma técnica alternativa consiste em inocular as CT localmente, na região subcapsular renal. O objetivo do presente estudo foi analisar, em modelo experimental de doença renal crônica por nefrectomia 5/6 (Nx), a migração, a distribuição e o possível efeito renoprotetor da inoculação via subcapsular renal de 2 tipos de CT: derivadas da medula óssea (CTdmo) e mesenquimais (CTm). As CT foram coletadas de fêmur e tíbia de ratos doadores através da técnica de flushing. As CTdmo foram isoladas por gradiente de concentração e as CTm pela sua capacidade de aderência ao plástico e ambas marcadas com DAPI para a visualização no tecido. A caracterização das CT foi feita por citometria de fluxo e pela diferenciação celular in vitro. Foram realizados 2 protocolos experimentais. No protocolo I, CTdmo (1x106) foram inoculadas em ratos fêmeas e, no protocolo II, CTm (2x105) foram inoculadas em ratos machos. A região inoculada foi a subcapsula renal e os animais foram acompanhados por 15 e 30 dias. Os animais foram subdivididos nos grupos: Sham, ratos submetidos à cirurgia fictícia; Sham+CT, ratos submetidos à cirurgia fictícia que receberam CT (CTdmo ou CTm); Nx, ratos submetidos a nefrectomia 5/6; Nx+CT, Nx ratos que receberam CT (CTdmo ou CTm). Para avaliar a localização das CTdmo no tecido renal, utilizou-se a coloração de tricrômio de Masson e foi realizada uma análise semiquantitativa para avaliar o grau de infiltração. Foram analisadas a pressão arterial (PA), a albuminúria e a creatinina sérica. Para os animais que receberam CTm foi realizada a análise de parâmetros histológicos e a análise de marcadores inflamatórios, de células em atividade proliferativa, de miofibroblastos e de podócitos. Os resultados do Protocolo I avaliando a análise da infiltração no tecido renal das CTdmo marcadas com DAPI mostrou, em 5 dias, evidente infiltração das células da região subcapsular em sentido ao córtex e medula, inclusive presente em glomérulos. Ratos fêmeas Nx que receberam a inoculação das CTdmo na região da subcapsular renal não apresentaram melhora nos parâmetros que avaliaram a função renal. Protocolo II: as CTm cultivadas mostraram grande capacidade de aderência, crescimento em colônia e de diferenciação em células osteogênicas. A análise por citometria mostrou-se positiva para CD44 e CD90, com uma pequena população de células de CD34, CD45 e CD31, confirmando a presença preponderante de CTm. A inoculação de CTm em ratos Nx proporcionou um bloqueio da progressão da doença renal. Enquanto ratos Nx machos apresentaram elevada PA com 15 e 30 dias (149,6±9,1 e 191,7±2,8 mmHg) a inoculação de CTm promoveu significante redução após 30 dias (145,2±6,8 mmHg; p<0,05 vs Nx). Em ratos Nx foi observado um aumento na creatinina aos 15 e 30 dias (1,13±0,08 e 1,16±0,26 mg/dL) e a inoculação de CTm promoveu uma marcante redução aos 15 dias (0,58±0,03 mg/dL; p<0,05 vs Nx). A albuminúria foi elevada nos ratos Nx aos 15 e 30 dias (41,7±10,8 mg/24h e 138,7±33,6 mg/24h) enquanto os animais do grupo Nx+CTm aos 15 e 30 dias apresentaram diminuição significativa (4,6±1,5 mg/24h e 23,4±7,7 mg/24h; p<0,0001 vs Nx). A glomeruloesclerose do grupo Nx+CTm apresentou aos 30 dias uma redução significativa em relação ao grupo Nx (5,4±2,5% vs 22,0±6,1%, respectivamente; p<0,0001). A análise da fibrose intersticial não revelou diferença após 15 dias e 30 dias no grupo Nx+CTm em relação ao grupo Nx. Com relação ao número de macrófagos, linfócitos e de células em atividade proliferativa, os animais que receberam CTm apresentaram uma discreta diminuição de sua expressão no tecido renal. A expressão de -actina se reduziu significativamente no grupo Nx+CTm. Quanto à expressão de WT-1, específico para podócitos, os animais Nx+CTm tiveram aumento significativo da marcação em relação ao grupo Nx. Em resumo, após a inoculação de CT na região da subcapsula renal, houve marcante migração e distribuição das mesmas em direção à cortical e à medular. A inoculação de CTm proporcionou um efeito renoprotetor no modelo de nefrectomia 5/6. Sendo assim, a inoculação subcapsular renal pode representar uma importante via de inoculação, permitindo assim que um número maior de células atue na proteção da progressão da doença.Stem cells (SCs) offer therapeutic potential for the treatment of renal diseases, due to the possibility of tissue regeneration and functional recovery. Various studies have shown renoprotection by SCs in experimental models of acute kidney disease. However, only a few studies have studied their effect in chronic kidney disease. The beneficial effect of SCs seems related to their capacity to differentiate or to secrete paracrine/endocrine factors. In this context, the inoculation route or the number of SCs homing in the injured region can play a crucial role. Therefore, transplantation of MSC through the intravenous route does not seem to be best suited for delivery of an important number of cells to the target organ. An alternative technique consists in local delivery of SCs in the subcapsular region of the kidney. The objective of the present study is to analyze the migration, distribution and potential renoprotective effect of the subcapsular inoculation of two types of SC - BSMC and mesenchymal stem cell (MSC) - in an experimental model of chronic kidney disease, the 5/6 nephrectomy (Nx). SCs were collected from the femur and tibia of donor rats by flushing. BSMC were isolated by centrifugation on a concentration gradient and MSCs were isolated by their capacity to adhere to plastic. Both types of SC were stained with DAPI to allow visualization in tissues. SC characterization was carried out by flow cytometry and differentiation in culture. Two experimental procedures were performed. In protocol I, BSMC (106 cells) were injected in female rats and in protocol II, MSCs (2x105 cells) were injected in male rats. Animals were divided into 4 groups: SHAM, sham-operated rats; SHAM+SC, sham-operated rats receiving BSMC or MSCs; Nx, rats undergoing 5/6 nephrectomy; Nx+SC, 5/6 Nx rats receiving BSMC or MSCs. We used Massons Trichrome staining and a semiquantitative analysis according to the degree of infiltration to follow the localization of BSMC in the renal tissue and to quantify their infiltration, respectively. The following parameters were studied: arterial blood pressure (AP), proteinuria (Uprot), albuminuria (Ualb) and serum creatinine (Screat). For the animals receiving SCs, analysis of histology, of inflammatory markers, of proliferating cells and of podocytes was performed. Results from Protocol I assessing DAPI-stained BSMC showed marked infiltration in 5 days from the subcapsular region to the cortex and the medulla, including presence in the glomeruli, over a period of 15 days. Female rats that received subcapsular injection of BSMC did not show improvement of the parameters used to assess kidney function. Protocol II: cultured MSCs demonstrated an ability to adhere to plastic, to grow in colonies and to differentiate in osteogenic cells. Quantitative analysis of cell markers by flow cytometry showed that isolated cells were positive for CD44 and CD90, with a small population of cells positive for CD31, CD34 and CD45, confirming a preponderant presence of MSCs. Inoculation of MSCs in Nx rats blocked the progression of the renal disease. Elevated AP in Nx rats at 15 and 30 days (149.6 ± 9.1 and 191.7 ± 2.8 mm Hg, respectively) was significantly reduced by inoculation of MSCs at 30 days (145.2 ± 6.8 mm Hg, p<0.05 vs Nx). Nx rats showed increased creatinine at 15 and 30 days (1.13 ± 0.08 and 1.16 ± 0.26 mg/dL, respectively) that was significantly reduced by injection of MSCs at 15 days (0.58 ± 0.03 mg/dL, p<0.05 vs Nx). Albuminuria was increased in Nx rats at 15 and 30 days (41.7 ± 10.8 and 138.7 ± 33.6 mg/24h, respectively) and was reduced in the Nx+MSC group at both time points (4.6 ± 1.5, and 23.4 ± 7.7 mg/24h, respectively; p<0.0001 vs Nx). Histologic analysis showed that glomerulosclerosis at 30 days in the Nx+MSC group was significantly reduced as compared to the Nx group (5.4 ± 2.5 % vs 22.0 ± 6.1 %, p<0.0001). Analysis of interstitial fibrosis did not show difference after 15 and 30 days in the Nx+MSC group compared to Nx group. Nx rats receiving MSCs showed slightly decreased inflammation markers, macrophages and lymphocytes, and proliferating cells in the renal tissue when compared to Nx rats. Analysis of myofibroblasts showed a significant decrease in expression of -smooth muscle actin in Nx+MSC rats compared to Nx rats. Podocyte number was analyzed by detection of WT-1, a specific marker. Nx rats receiving MSC had a significantly higher number of podocytes than Nx rats. In conclusion, our results show that after inoculation in the subcapsular region, SCs migrate throughout the cortex in direction of the medulla. Subcapsular inoculation of MSC provides a renoprotective effect in the model of 5/6 nephrectomy. Therefore, subcapsular inoculation could represent an important route of delivery of SCs to the kidney that allows a higher number of cells to act in the protection from progression of the disease.
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Song, Shangqing [Verfasser], e Hans-Joachim [Akademischer Betreuer] Anders. "A histology-based four protein array for postoperative outcome prediction in clear cell renal cell carcinoma / Shangqing Song ; Betreuer: Hans-Joachim Anders". München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/114485718X/34.
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Jaldin, Rodrigo Gibin. "Efeito do clampeamento aórtico no estresse oxidativo e na função renal durante cirurgia aórtica minimamente invasiva estudo experimental em porcos /". Botucatu, 2016. http://hdl.handle.net/11449/141496.
Abstract (sommario):
Orientador: Winston Bonetti YoshidaCoorientador: Ricardo de Alvarenga Yoshida
Resumo: Contexto: O clampeamento infrarrenal e trauma cirúrgico estão associados a alterações hemodinâmicas e oxidativas que podem comprometer a função renal pós-operatória. Ademais, a colite isquêmica é uma grave complicação da cirurgia da aorta abdominal. É possível que ocorram diferenças na fisiopatologia destas complicações associadas às diferentes modalidades de tratamento do aneurisma de aorta abdominal. Objetivo: Avaliar o estresse oxidativo, os distúrbios hemodinâmicos, lesão renal e as alterações histopatológicas em fragmentos de cólon esquerdo de porcos submetidos a modelo experimental de interrupção aguda de fluxo sanguíneo aórtico, comparando os diferentes acessos cirúrgicos: tradicional, endovascular ou videolaparoscópico. Material e Métodos: 30 porcos, fêmeas, com 15-30kg, foram divididos aleatoriamente em 3 grupos, sendo todos submetidos, sob anestesia geral inalatória, a interrupção de fluxo da aorta abdominal por 60 minutos, por diferentes técnicas: Grupo C (n=10), através de laparotomia transperitoneal; Grupo L (n=10), através da técnica totalmente laparoscópica; Grupo EV(n=10), através da via endovascular por insuflação de balão de oclusão de aorta. Foi feita monitorização intraoperatória de pressão arterial, frequência cardíaca, balanço hídrico e coleta de amostras de sangue antes do procedimento e 60 minutos após a reperfusão. Os desfechos primários estudados foram: volume de sangramento, estresse oxidativo sistêmico (dosagens de Malondialdeido, Glutationa Reduzi... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Context: Infrarenal aortic cross-campling and surgical trauma are associated with hemodynamic and oxidative alterations that may impair postoperative renal function. Furthermore, Colonic ischemia is a relatively uncommon but devastating complication of abdominal aortic surgery. Its occurrence and severity is related to operative and anesthetic trauma. Therefore, it is a known complication of all different modalities of treatment of abdominal aortic aneurysm. Objective: To evaluate oxidative stress, hemodynamic disorders, renal injuries and histopathological changes in the left colon fragments of pigs subjected to the experimental model of acute aortic flow interruption, comparing the approaches by laparotomy, endovascular surgery and laparoscopic surgery. Materials and Methods: A total of 30 female pigs weighing 15-30 kg were randomly divided into 3 groups, all of which were subjected, under general ihaling anesthesia, to a 60-minute interruption of abdominal aortic flow by means of different techniques: C Group (n=10), through transperitonial laparotomy; L Group (n=10), through a totally laparoscopic technique; EV Group (n=10), through the endovascular procedures by insufflating the occlusion balloon of the aorta. Blood pressure, heart beat, and water balance intraoperative monitoring was performed and blood samples were collected both before the procedure and 60 minutes after reperfusion. The primary outcomes studied were: bleeding volume, systemic oxidative stress (levels... (Complete abstract click electronic access below)
Doutor
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Mosley, Claudia Foulk. "Fatemapping of Urothelial Cell Lineages During Normal Kidney Development and Renal Pathogenesis". The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543231681321385.
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Jaldin, Rodrigo Gibin [UNESP]. "Efeito do clampeamento aórtico no estresse oxidativo e na função renal durante cirurgia aórtica minimamente invasiva: estudo experimental em porcos". Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/141496.
Abstract (sommario):
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Contexto: O clampeamento infrarrenal e trauma cirúrgico estão associados a alterações hemodinâmicas e oxidativas que podem comprometer a função renal pós-operatória. Ademais, a colite isquêmica é uma grave complicação da cirurgia da aorta abdominal. É possível que ocorram diferenças na fisiopatologia destas complicações associadas às diferentes modalidades de tratamento do aneurisma de aorta abdominal. Objetivo: Avaliar o estresse oxidativo, os distúrbios hemodinâmicos, lesão renal e as alterações histopatológicas em fragmentos de cólon esquerdo de porcos submetidos a modelo experimental de interrupção aguda de fluxo sanguíneo aórtico, comparando os diferentes acessos cirúrgicos: tradicional, endovascular ou videolaparoscópico. Material e Métodos: 30 porcos, fêmeas, com 15-30kg, foram divididos aleatoriamente em 3 grupos, sendo todos submetidos, sob anestesia geral inalatória, a interrupção de fluxo da aorta abdominal por 60 minutos, por diferentes técnicas: Grupo C (n=10), através de laparotomia transperitoneal; Grupo L (n=10), através da técnica totalmente laparoscópica; Grupo EV(n=10), através da via endovascular por insuflação de balão de oclusão de aorta. Foi feita monitorização intraoperatória de pressão arterial, frequência cardíaca, balanço hídrico e coleta de amostras de sangue antes do procedimento e 60 minutos após a reperfusão. Os desfechos primários estudados foram: volume de sangramento, estresse oxidativo sistêmico (dosagens de Malondialdeido, Glutationa Reduzido e atividade de Glutationa Peroxidase) e lesão renal pela histologia e dosagens de Creatinina, de Cistatina-C e avaliação do estresse oxidativo no parênquima renal. Uma amostra transversal total do cólon sigmoide, logo acima de deflexão peritoneal, foi retirada para biópsia. Estas foram submetidas à análise histopatológica pelo H&E e pela imunohistoquímica da Caspase-3 por patologista cego para os grupos. Resultados: O grupo C necessitou maior reposição de cristalóide. O débito urinário foi significativamente maior no grupo EV. Houve redução da temperatura corporal ao longo do procedimento apenas nos grupos C e L e redução da pressão arterial média após a liberação do fluxo sanguíneo aórtico significantiva no grupo C. Houve aumento de Cistatina C no grupo EV. O grupo L apresentou o menor volume de diurese no intraoperatório. A análise histopatológica mostrou alterações do tipo edema e achatamento dos vilos em dois animais L e em um animal EV. Na análise pelo método da Caspase-3 houve maior número de apoptoses e menor número de neurônios nos animais EV. Conclusão: Na via endovascular ocorre manutenção da temperatura corporal e menor perda líquida. A alteração funcional renal foi mais pronunciada em EV e a lesão microestrutural mais frequente em EV e L. O grupo endovascular teve isquemia de cólon mais intensa, provavelmente relacionada com a maior manipulação endovascular com fios-guias e cateteres o que, por sua vez, pode levar a espasmos e microembolizações no leito arterial. Apesar de serem métodos menos invasivos, houve lesões renais discretas e mais pronunciadas nas técnicas endovascular e videolaparoscópica. A ausência de laparotomia e de manipulação intra-abdominal no grupo EV parece ser a grande vantagem do método em relação à estabilidade hemodinâmica intra-operatória. Estudos envolvendo maiores tempos de isquemia e de reperfusão são necessários para elucidar melhor estes efeitos da interrupção de fluxo aórtico sobre a mucosa colônica e o parênquima renal.
Context: Infrarenal aortic cross-campling and surgical trauma are associated with hemodynamic and oxidative alterations that may impair postoperative renal function. Furthermore, Colonic ischemia is a relatively uncommon but devastating complication of abdominal aortic surgery. Its occurrence and severity is related to operative and anesthetic trauma. Therefore, it is a known complication of all different modalities of treatment of abdominal aortic aneurysm. Objective: To evaluate oxidative stress, hemodynamic disorders, renal injuries and histopathological changes in the left colon fragments of pigs subjected to the experimental model of acute aortic flow interruption, comparing the approaches by laparotomy, endovascular surgery and laparoscopic surgery. Materials and Methods: A total of 30 female pigs weighing 15-30 kg were randomly divided into 3 groups, all of which were subjected, under general ihaling anesthesia, to a 60-minute interruption of abdominal aortic flow by means of different techniques: C Group (n=10), through transperitonial laparotomy; L Group (n=10), through a totally laparoscopic technique; EV Group (n=10), through the endovascular procedures by insufflating the occlusion balloon of the aorta. Blood pressure, heart beat, and water balance intraoperative monitoring was performed and blood samples were collected both before the procedure and 60 minutes after reperfusion. The primary outcomes studied were: bleeding volume, systemic oxidative stress (levels of Malondialdehyde, Reduced Glutathione and Glutathione Peroxidase activity) and renal injuries through histology, Creatinine and Cystatin C levels and by assessing oxidative stress on renal parenchyma. A sample of the sigmoid colon, just above the peritoneal deflection, was collected. These were subjected to histopathologic analysis by H & E and immunohistochemical by Caspase-3. Results: C needed a larger amount of crystalloid replacement. Urine output was significantly higher in the EV group. Body temperature only reduced during the procedure in groups C and L and there was a significant reduction in the mean blood pressure in C after the aorta was unclamped. L presented a lower volume of diuresis in the intraoperative period. Histopathological analysis showed changes in edema type and flattened villi in two animals from L and EV groups. Caspase-3 showed more cells undergoing apoptosis and fewer neurons in the EV group. Conclusion: Body temperature is maintained and there is lower fluid loss in the endovascular pathway. Renal function alterations were more evident in EV and the microstructural injury was more frequent in Groups EV and L. The EV group had more severe colonic ischemia, probably related to greater manipulation with endovascular guide wires and catheters, which could lead to spasms and microembolization in small vessels. Although they are less invasive methods, there were discreet and more pronounced renal injuries in the endovascular and video laparoscopic techniques. The great advantage of the method, with respect to hemodynamic stability during the intraoperative period, is the absence of laparotomy and intra-abdominal manipulation in EV. More studies involving longer periods of ischemia and reperfusion may help elucidate the effects of aortic flow disruption on colonic mucosa.
FAPESP: 12/50159-3
Libri sul tema "Renal histology":
1
Sampaio, Francisco J. B. Renal anatomy applied to urology, endourology, and interventional radiology. New York: Thieme Medical Publishers, 1993.
2
Schulthess, Gustav Konrad von. Morphology and function in MRI, cardiovascular and renal systems. Berlin: Springer-Verlag, 1989.
3
Sharpstone, P., e J. A. Trafford. Renal Glomerular Diseases. Springer, 2012.
4
Sharpstone, P., e J. A. Trafford. Renal Glomerular Diseases. Springer Netherlands, 2012.
5
Bardin, Thomas, e Tilman Drüeke. Renal osteodystrophy. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0149.
Abstract (sommario):
Renal osteodystrophy (ROD) is a term that encompasses the various consequences of chronic kidney disease (CKD) for the bone. It has been divided into several entities based on bone histomorphometry observations. ROD is accompanied by several abnormalities of mineral metabolism: abnormal levels of serum calcium, phosphorus, parathyroid hormone (PTH), vitamin D metabolites, alkaline phosphatases, fibroblast growth factor-23 (FGF-23) and klotho, which all have been identified as cardiovascular risk factors in patients with CKD. ROD can presently be schematically divided into three main types by histology: (1) osteitis fibrosa as the bony expression of secondary hyperparathyroidism (sHP), which is a high bone turnover disease developing early in CKD; (2) adynamic bone disease (ABD), the most frequent type of ROD in dialysis patients, which is at present most often observed in the absence of aluminium intoxication and develops mainly as a result of excessive PTH suppression; and (3) mixed ROD, a combination of osteitis fibrosa and osteomalacia whose prevalence has decreased in the last decade. Laboratory features include increased serum levels of PTH and bone turnover markers such as total and bone alkaline phosphatases, osteocalcin, and several products of type I collagen metabolism products. Serum phosphorus is increased only in CKD stages 4-5. Serum calcium levels are variable. They may be low initially, but hypercalcaemia develops in case of severe sHP. Serum 25-OH-vitamin D (25OHD) levels are generally below 30 ng/mL, indicating vitamin D insufficiency or deficiency. The international KDIGO guideline recommends serum PTH levels to be maintained in the range of approximately 2-9 times the upper normal normal limit of the assay and to intervene only in case of significant changes in PTH levels. It is generally recommended that calcium intake should be up to 2 g per day including intake with food and administration of calcium supplements or calcium-containing phosphate binders. Reduction of serum phosphorus towards the normal range in patients with endstage kidney failure is a major objective. Once sHP has developed, active vitamin D derivatives such as alfacalcidol or calcitriol are indicated in order to halt its progression.
6
Renal disease: Classification and atlas. New York: Igaku-Shoin, 1987.
7
Rajakariar, Ravindra, e Muhammad M. Yaqoob. The patient with sarcoidosis. A cura di Giuseppe Remuzzi. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0156.
Abstract (sommario):
Renal involvement in sarcoidosis is common and often under-recognized. The most frequent manifestation is acute kidney injury secondary to hypercalcaemia and granulomatous tubulointerstitial nephritis. The latter can lead to both acute kidney injury and to slowly progressive chronic renal impairment with concomitant chronic damage seen on histology. This chapter describes the types of renal disease that may occur in sarcoidosis and the pathogenesis, clinical presentation, diagnosis, and treatment of the patient with sarcoidosis. Corticosteroid therapy is the cornerstone of therapy. In patients with granulomatous tubulointerstitial nephritis, the authors recommend long-term, low-dose maintenance steroids.
8
Argote-Romero, Graciela. Wilms Tumor. A cura di Kirk Lalwani, Ira Todd Cohen, Ellen Y. Choi e Vidya T. Raman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190685157.003.0041.
Abstract (sommario):
Wilms tumor, known as well as nephroblastoma, is the most common primary malignant renal tumor in children. Over 95% of all renal tumors in patients under the age of 15 are Wilms tumors. The mean age at the time of diagnosis is 3.5 years. Wilms tumors are usually an incidental finding, a large abdominal mass discovered by a family member or pediatrician. Hematuria and hypertension can be present at the time of initial diagnosis. Up to 8% of the patients will have von Willebrand disease; therefore, all patients should have baseline coagulation studies. All patients should have either computed tomography of the abdomen and pelvis with oral and intravenous contrast or magnetic resonance imaging of the abdomen and pelvis with gadolinium. Treatment includes radical nephrectomy, chemotherapy, and, in some cases, radiotherapy. Emergency surgery is rarely. The disease-free survival rate is 86% for favorable-histology tumors and 64% for anaplastic tumors.
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Sakhuja, Vinay, e Harbir Singh Kohli. Malaria. A cura di Vivekanand Jha. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0183_update_001.
Abstract (sommario):
Of the four pathogenic malarial species, clinically significant renal dysfunction is mainly associated with Plasmodium malariae and Plasmodium falciparum infections.P. falciparum infection frequently causes acute kidney injury (AKI). AKI may be the sole manifestation with a complete recovery after treatment or it may be a part of multi-organ failure which is often fatal. AKI due to Plasmodium vivax infection alone or as a result of mixed infection by vivax and falciparum can also occur.‘Quartan malarial nephropathy’ has been attributed to P. malariae infection although this relationship must be regarded as not proven. It describes nephropathy occurring predominantly in children and young adults in Africa. A full-blown nephrotic syndrome is seen in about half the patients and a chronic progressive membranoproliferative glomerulonephritis is usually seen on histology. Spontaneous remission of established nephropathy is rare, and most patients slowly progress to end-stage renal failure over 3 to 5 years even after successful eradication of the infection. The pathological description is such that it could have alternative aetiologies, including other infections.
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Carlson, Neil R., e Melissa Birkett. Physiology of Behavior [RENTAL EDITION]. Pearson Education Canada, 2019.
Capitoli di libri sul tema "Renal histology":
1
Visser, Walter J. "Aluminum induced bone disease: Histology". In Aluminum and renal failure, 241–47. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-1868-9_18.
2
Ditscherlein, G. "Renal Histology in Hypertensive Diabetics". In Diabetes and Hypertension, 36–42. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73232-4_5.
3
Edgley, Amanda J., Renae M. Gow e Darren J. Kelly. "Laser-Capture Microdissection and Pressure Catapulting for the Analysis of Gene Expression in the Renal Glomerulus". In Histology Protocols, 29–40. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-345-9_3.
4
Khadivi, Bahram, e Ehtisham Mahmud. "Angiographic, Physiological, and Virtual Histology Indices of Renal Perfusion to Guide Renal Artery Stenting". In Endovascular Interventions, 389–400. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7312-1_34.
5
Pascual, J., T. Cano, F. J. Burgos, C. Cuesta, A. Tato, G. Fernández-Juárez, V. Gómez, L. Orofino, F. Liaño e J. Ortuño. "Iliac Artery Histology and Renal Allograft Blood Flow Measured by Doppler Spectrum Analysis". In Late Graft Loss, 234. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5434-5_56.
6
Mir, Maria Carmen, Brian I. Rini e Steven C. Campbell. "Clinical and Management Implications Associated with Histologic Subtypes of Renal Cell Carcinomas". In Genitourinary Pathology, 341–54. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2044-0_27.
7
Molloy, Phillip. "Renal Histology". In How To Draw Anatomy, 159–62. Oxford University PressOxford, 2023. http://dx.doi.org/10.1093/med/9780192883322.003.0014.
Abstract (sommario):
Abstract This chapter offers a simple histological diagram of the kidney and adrenal systems. Some useful hot tips will help you to additionally remember different chemicals secreted by the layers of the adrenal gland.
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Lindberg, Matthew R., e Laura W. Lamps. "Ureter and Renal Pelvis". In Diagnostic Pathology: Normal Histology, 296–99. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-323-54803-8.50067-x.
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"URINARY SYSTEM 2: RENAL PELVIS, CALYCES, URETER, BLADDER AND URETHRA". In Organ Histology, 263–71. WORLD SCIENTIFIC, 1997. http://dx.doi.org/10.1142/9789812830272_0018.
10
Kote, Neelkanth. "Renal System". In Practical Manual of Histology for Medical Students, 114. Jaypee Brothers Medical Publishers (P) Ltd., 2014. http://dx.doi.org/10.5005/jp/books/12380_18.
Atti di convegni sul tema "Renal histology":
1
Hsieh, Tsu-Yi, Yi-Ming Chen, Wei-Ting Hung, Hsin-Hua Chen, Kuo-Lung Lai, Ching-Tsai Lin, Yi-Da Wu, Wen-Nan Huang, Chih-Wei Tseng e Yi-Hsing Chen. "SAT0173 RENAL GALLIUM SCAN CORRELATED WITH INFLAMMATION IN RENAL HISTOLOGY OF PATIENTS WITH LUPUS NEPHRITIS". In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.8266.
2
Lucarelli, Nicholas, Donghwan Yun, Dohyun Han, Brandon Ginley, Kyung C. Moon, Avi Rosenberg, John E. Tomaszewski, Seung S. Han e Pinaki Sarder. "Computational integration of renal histology and urinary proteomics using neural networks". In Digital and Computational Pathology, a cura di John E. Tomaszewski e Aaron D. Ward. SPIE, 2022. http://dx.doi.org/10.1117/12.2613500.
3
Nossent, J., W. Raymond, A. Kang, D. Wong, M. Ognejovic e A. Chakera. "AB0586 Current impact of ethnicity on renal histology and outcome of lupus nephritis". In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.2567.
4
Gupta, Laxmi, Barbara Mara Klinkhammer, Peter Boor, Dorit Merhof e Michael Gadermayr. "Stain independent segmentation of whole slide images: A case study in renal histology". In 2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018). IEEE, 2018. http://dx.doi.org/10.1109/isbi.2018.8363824.
5
Zhou, Boran, Alexander Rachev e Tarek Shazly. "Active Stress in the Porcine Renal Artery". In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14427.
Abstract (sommario):
As a typical muscular conduit artery, the renal artery manifests an active response when the vascular smooth muscle is stimulated to contract. To present there are few experimental data [1] and no constitutive formulation of the renal arterial tissue that accounts for the active stress developed when the smooth muscle cells (SMCs) are stimulated to contract. Most studies identify the circumferential and axial active stresses by processing the in-vitro experimentally recorded change in diameter and axial force in a tubular arterial specimen inflated by an internal pressure, kept at constant axial stretch ratio, and with the SMCs stimulated to relax or contract. It is assumed that the stress borne by the extracellular matrix, termed as passive stress, and the active stress generated by the stimulated SMCs are additive. The directions of the active stresses and functional dependence on the strain measures are often postulated on the basis of histology, biophysics of SMC contraction, and an a priori guess, rather than on recordable mechanical information. The only exception is a recently proposed approach that allows decoupling of the passive and active response and identifying the arguments and the analytical form of the active stress directly from experimental data [2]. In this study, we follow this approach and determine the active stress in the porcine renal artery.
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Chen, Jiayuan, Yu Wang, Ruining Deng, Quan Liu, Can Cui, Tianyuan Yao, Yilin Liu et al. "Spatial pathomics toolkit for quantitative analysis of podocyte nuclei with histology and spatial transcriptomics data in renal pathology". In Digital and Computational Pathology, a cura di John E. Tomaszewski e Aaron D. Ward. SPIE, 2024. http://dx.doi.org/10.1117/12.3006318.
7
Boelaert, J., P. Lijnen, R. Daneels, M. Schurgers e A. Amery. "SULPHINPYRAZONE (SP) AS A CAUSE OF ACUTE RENAL FAILURE (ARF): A REVIEW". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644813.
Abstract (sommario):
A total of 41 patients (all but one since 1980, 10 from our own group) have been reported with ARF due to SP. Their mean age was 58 years. 84 % of them received SP for coronary or cerebrovascular disease. Signs of pre-existing renal disease were absent in 91%of cases. Daily dosage of SP was < 400 mg in 21 %, 600 mg in 21 % and 800 mg in 58 % of the cases. ARF appeared within the first day of R/ with SP in31 % of cases(median delay of 4 days). Oliguria was present in 41 % and lumbar or abdominal pain in 26 %. Urinalysis showed uric acid crystals in 13 %. Serum creatinine peaked at a mean of 7.2 mg%. Extrarenal signs (fever, rash) were rare (10 %). 3 patients (8 %) died; renal function recovered in the others, acute dialysis being needed in 6 cases (15 %). Renal histology (11 cases) showed either no lesions (2), minimal tubulo-interstitial lesions (3), discrete interstitial infiltration (2), acute interstitial nephritis (3) or acute tubular necrosis (1).SP can cause ARF by 3 mechanisms which are not mutually exclusive : acute urate nephropathy, acute (immunological) interstitial nephritis or acute ischaemia due to inhibition of the renal synthesis of kallikrein-kinin and/or vasodilatory prostaglandins. We suggest that the latter mechanism is the most prevalent. The effect of SP on the renal prostaglandin synthesis is not settled; thurinary excretion of kallikrein is significantly depressed by SPIn conclusion : since 1980, R/ with SP is a frequent cause of ARF Practically: 1) the indications for sp should be taken with care; 2) a progressive increase in the dosage of SP may decreses the incidence of ARF.
8
SCHLEGEL, N., J. MOAKE, C. LOIRAT, M. F. HURTAUD, S. LEVY-TOLEDANO e H. MATHIEU. "CHILDHOOD HEMOLYTIC UREMIC SYNDROME (HUS) : VON WILLEBRAND FACTOR (vWF) AND PLATELET AGGREGATING ACTIVITY (PAA) STUDIES". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643475.
Abstract (sommario):
It has been suggested that a vWF High Molecular Weight Multi-mers (HMWM) decrease or a PAA were involved in the pathogenesis of HUS. We have studied 8 children (6 girls,_2 boys; 7 months-8_1/2 years old) with HUS : plasma creatinine /μmol/l; mean(range)/=306 (105-524), hemoglobin (g/100ml)-7(6.3-7.8), schistocytes (%)=8(1-18), platelets (x103/mm3)-57(10-115). The vWF was studied quantitatively (antigen ; vWF RAg assay) and qualitatively (multimeric pattern : immunoblotting and autoradiography). PAA studied by incubating the patient's platelet poor plasma (RPR) with washed normal platelets (aggregometer, % light transmission) and confirmed by Thromboxane B2 (TXB2) assay and [14C] Serotonine release study. The PAA was characterized by studying the in vitro effect of several platelet aggregation inhibitors, Immunoglobulins (Igs) and Fresh Frozen Plasma (FFP) on the platelet aggregation.An increase of vWF RAg (%) was observed in 6 cases : mean:330, and possibly related with renal failure. A vWF HMWM decrease was found in 3 patients : 2/3 with associated infection(E.Coli, Pneumococcus), 1/3 with severe hemolysis. Two of these 3 patients had a favourable renal outcome and 1 a severe course (chronic hemodialysis, Arterial Thrombotic MicroAngiopathy at renal histology).An important PAA was evidenced only in 1 patient : post bone-marrow graft HUS during neuroblastoma(NB),arterial hypertension and chronic renal failure. This PAA was Ca++, TXB2 and cAMP dependent; it was moderately inhibited in vitro by Igs and FFP, but persisted after 5 days of Igs infusion (0.3g/Kg/day). Treatment with aspirin and dipyridamole (10mg/Kg/day each) suppressed the patient platelet auto-aggregation although the PAA persisted (follow up:10months). The PAA did not seem to be related with the NB (absence of GD2 ganglioside, specific marker of NB); it could be related with anti platelet antibodies. The coexistence of the two abnormalities could not be demonstrated in our patients.In conclusion, a vWF HMWM decrease was found in 3 out of 8 children patients with HUS. Its presence was not correlated with the severity of the disease. We could demonstrate the presence of PAA during childhood HUS in only 1 post bone-marrow graft case. The PAA characterization is useful for therapeutic decisions and contributes to a better pathogenetic understanding.
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He, Xiaoming, Shawn Mcgee, James E. Coad, Paul A. Iaizzo, David J. Swanlund, Stan Kluge, Eric Rudie e John C. Bischof. "Investigation of the Thermal and Injury Behavior During Microwave Thermal Therapy of Porcine Kidney". In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-32048.
Abstract (sommario):
In this paper, we report on the characterization of microwave therapy of normal porcine kidneys both in vitro and in vivo. This technology is being developed for eventual use in the treatment of small renal cell carcinoma (RCC) by minimally invasive procedures. During experiments, microwave energy was applied through an interstitial microwave probe (Urologix, Plymouth, MN) to the kidney cortex with occasional involvement of the kidney medulla. The thermal histories at several locations were recorded. After treatment, the kidneys were bisected and small tissue slices were cut out at approximately the same depth as the thermal probes. The tissue slices were further processed for histological study. Both cellular injury and the area of microvascular stasis were quantitatively evaluated by histology. Absolute rate kinetic models of cellular injury and vascular stasis were developed and fit to this data. A 3-D finite element thermal model based on the Pennes Bioheat equation was developed and solved using a commercial software package (ANSYS, V5.7). The Specific Absorption Rate (SAR) of the microwave probe was measured experimentally in tissue equivalent gel-like solution. The thermal model was first validated by the measured in vitro thermal histories. It was then used to determine the blood perfusion term in vivo.
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Nascimento, Giovanna Bezerra do, Júlia Yasmin Alves Silva, Max Victor Arruda Alves e Amanda Soares de Vasconcelos. "ASPECTOS HISTOLÓGICOS DA NEFROTOXICIDADE CAUSADA PELO CONSUMO DE CARAMBOLA EM PESSOAS COM FUNÇÃO RENAL ALTERADA". In I Congresso On-line Nacional de Histologia e Embriologia Humana. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/rems/3222.
Abstract (sommario):
Introdução: A carambola (Averrhoa carambola) é uma fruta comum em países tropicais, a exemplo do Brasil. Rica em fontes minerais e vitaminas, bem como em caramboxina e ácido oxálico. Esses últimos podem causar efeitos negativos no corpo humano, resultando na deposição de cristais de oxalato nos túbulos renais, com potencial de gerar lesão tubular renal aguda, quando essa fruta é consumida em excesso ou quando há alteração da função renal. Existem 2 tipos de carambola: a azeda, com o teor de oxalato em torno de 7 mg/g; e a doce, na qual a concentração corresponde a 0,4-0,8 mg/g. Objetivo: Compreender o mecanismo pelo qual a carambola ocasiona danos aos túbulos renais do ponto de vista histológico. Metodologia: Revisão de literatura utilizando as bases de dados ScienceDirect e Pubmed. Foram escolhidos os artigos referentes ao intervalo de tempo 2017-2022, nos idiomas português, inglês e espanhol, através dos termos da área de busca: (“lesão renal” OR “acute kidney injury”) AND (carambola OR “fruit star”). Artigos que tangenciassem o tema, não abordando o objetivo de estudo foram excluídos. Resultados e discussão: A literatura encontrada relaciona a ingestão de carambola com lesões renais a partir da formação de cristais de oxalato nesta região. Nos trabalhos analisados observou-se que o consumo dessa fruta em excesso pode acarretar danos à fisiologia renal, majoritariamente a pacientes portadores de alguma patologia pré-existente nos rins, estando estes mais propícios a evoluir para um quadro de doença renal crônica. Na visão histológica, os artigos observados trazem que os cristais de oxalato de cálcio, vistos através da birrefringência sob luz polarizada, quando depositados ocasionam uma reação inflamatória que resulta em edema e fibrose dos túbulos renais, o que prejudica a função renal; podendo, inclusive, evoluir com necrose tecidual. A filtração e a secreção tubular de oxalato causam aumento excessivo na sua concentração local, o que induz a citotoxicidade do tecido dos túbulos renais com perda deste epitélio. Conclusão: Apesar das evidências, mais estudos são necessários para caracterizar o mecanismo fisiopatológico da toxicidade dos componentes da carambola.