Tesi sul tema "Rathwa"
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Karnyski, Margaret A. "Ethnomedical and biomedical health care and healing practices among the Rathwa adivasi of Kadipani village, Gujarat State, India". [Tampa, Fla] : University of South Florida, 2009. http://purl.fcla.edu/usf/dc/et/SFE0003050.
Testo completoMattsson, Cecilia, e Ida Hermanseter. "Att ratta eller rata bilen? : En fallstudie på Östra Torggatan i Karlstad med fokus på mobility management". Thesis, Karlstads universitet, Institutionen för geografi, medier och kommunikation, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-56637.
Testo completoTIXIER, FAVREAU ANNIE. "Les kystes de la fente de rathke : presentation de 3 cas et revue de la litterature". Clermont-Ferrand 1, 1991. http://www.theses.fr/1991CLF13037.
Testo completoVannice, Jeremy M. "Aging and architecture : community rather than isolation". Virtual Press, 2005. http://liblink.bsu.edu/uhtbin/catkey/1327787.
Testo completoDepartment of Architecture
Rosberg, Caitlin. "Capers: Would you rather we wear spandex?" Miami University Honors Theses / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1178290210.
Testo completoDelaney, Angela Beth. "Sketches of someone I'd rather not know". Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2009r/delaney.pdf.
Testo completoTitle from PDF title page (viewed Jan. 29, 2010). Additional advisors: Robert J. Collins, Peter Donahue, Lawrence G. Wharton. Includes bibliographical references (p. 51).
Kennedy, M. Amelia. "Liberation : design that liberates rather than handicaps us /". Online version of thesis, 1989. http://hdl.handle.net/1850/10946.
Testo completoKebede, Endale Birhanu, Wolfgang Lutz, Cuaresma Jesus Crespo e Alexia Fürnkranz-Prskawetz. "Education rather than age structure brings demographic dividend". The National Academies of Sciences, Engineering, and Medicine, 2019. http://dx.doi.org/10.1073/pnas.1820362116.
Testo completoLutz, Wolfgang, Cuaresma Jesus Crespo, Endale Birhanu Kebede, Alexia Fürnkranz-Prskawetz, Warren Sanderson e Erich Striessnig. "Education rather than age structure brings demographic dividend". The National Academies of Sciences, Engineering, and Medicine, 2019. http://dx.doi.org/10.1073/pnas.1820362116.
Testo completoRaths, Evelyn [Verfasser]. "Restwertermittlung in der Unternehmensbewertung / Evelyn Raths". Baden-Baden : Nomos Verlagsgesellschaft mbH & Co. KG, 2019. http://d-nb.info/1183471491/34.
Testo completoRattka, Marta Małgorzata [Verfasser]. "Prokonvulsiva als pharmakologische Strategie zur Epilepsieprävention / Marta Małgorzata Rattka". Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2012. http://d-nb.info/1024503313/34.
Testo completoRathke, Alexander [Verfasser]. "Essays in Monetary Economics and Economic Development / Alexander Rathke". Aachen : Shaker, 2011. http://d-nb.info/107408778X/34.
Testo completoHedström, Jakob, e Petya Dimitrova. "Data Quality : An organizational rather than a technical concern". Thesis, Uppsala universitet, Företagsekonomiska institutionen, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-388349.
Testo completoJuraszek, Adriana. "Ecologia alimentar de carnívoros em remanescentes de mata atlântica entremeados por matriz silvicultural, na região sul do Brasil". Universidade Estadual do Oeste do Parana, 2014. http://tede.unioeste.br:8080/tede/handle/tede/706.
Testo completoThe objective of this study was to investigate the composition of sympatric carnivores diet living in forest fragments of Atlantic forest interspersed with Pinus sp. e Eucalyptus sp.The study was conducted in the county of Vargem Bonita and Ponte Serrada, state of Santa Catarina. The information regarding diet were obtained through analysis of feces collected during the period July 2006 to July 2008. The first chapter discusses the composition of the diet of the coati Nasua Nasua, in a subsequent period of fruiting Merostachys skvortzovii, that due to massive seed production causes a higher population of small rodents phenomenon popularly known as ratada, the hypothesis that this event may have influenced the composition of the diet. As there were no data on the composition of the diet for the study area in the period before fruiting M. skvortzovii, the hypothesis was tested based on other studies on the feeding ecology of the species in an Atlantic forest. The results indicate that mammals are the most important (62.1% ii PO) and more frequent items (FO = 100%). The Cricetidae family stood out based on frequency of occurrence (FO = 95.1%) and percentage of occurrence (PO = 59.0%) and Lutreolina crassicaudata based on biomass consumed (PB = 52.2%). In 39.0% of samples were found plant material, but is category was composed exclusively of foliar blades of grass. The observed results show that the fruiting of M. skvortzovii, may have influenced the diet given that the consumption of mammals differs from that recorded for the species in previous studies in the area Atlantic forest. The second chapter of this study evaluated qualitatively and quantitatively the composition of the diet, the width and dietary overlap of five species of felines and they: Leopardus tigrinus, L. wiedii, L. pardalis, Herpailurus yagouaroundi and Puma concolor. For this 460 fecal samples were analyzed and it was found that mammals are the most important items in the diet of cats with emphasis on family Cricetidade which occurred in 386 samples was expected especially for species with smaller. Overall, the results indicate high overlap values for the pairs L. tigrinus -L. pardalis and L. tigrinus -H. yagouaroundi. Despite high overlap valuesobserved during the sampling period we cannot say that competition for resources, species may occupy similar niches, but not identical to exploit food resources in different proportions over time. Furthermore, the abundance of rodents in this period may have allowed high dietary overlap, fact that can be investigated by analysis of the recent carnivorous diet of these, once not there previous study to the region investigated.
O objetivo geral deste estudo foi investigar a composição da dieta de carnívoros simpátricos que vivem em fragmentos florestais de Mata Atlântica entremeados por plantios de Pinus sp. E Eucalyptus sp.. O estudo foi conduzido nos municípios de Vargem Bonita e Ponte Serrada, estado de Santa Catarina. As informações a respeito da dieta foram obtidas por meio da análise de fezes coletadas durante o período de julho de 2006 a julho de 2008. O primeiro capítulo aborda a composição da dieta do quati Nasua nasua, em um período subsequente a frutificação de Merostachys skvortzovii, que devido a produção massiva de sementes ocasiona um aumento populacional de pequenos roedores fenômeno conhecido popularmente como ratada, tendo como hipótese de que este evento possa ter influenciado a composição da dieta. Como não havia dados sobre a composição da dieta para a área de estudo no período anterior à frutificação de M. skvortzovii, a hipótese foi testada com base em outros estudos que abordam a ecologia alimentar da espécie dentro do domínio Mata Atlântica. Os resultados obtidos indicam que mamíferos são os itens mais importantes (PO= 62,1%) e mais frequentes (FO=100%). A família Cricetidae destacou-se com base na frequência de ocorrência (FO= 95,1%) e porcentagem de ocorrência PO= 59.0% e Lutreolina crassicaudata com base na biomassa consumida PB= 52,2%. Em 39,0% das amostras foi encontrado material vegetal, porém esta categoria foi composta exclusivamente por lâminas folhares de gramíneas. Os resultados observados evidenciam que a frutificação de M. skvortzovii, pode ter influenciado na dieta tendo em vista que o consumo de mamíferos difere do registrado para a espécie em estudos anteriores realizados no domínio Mata Atlântica. O segundo capítulo deste estudo avaliou qualitativamente e quantitativamente a composição da dieta, a largura e a sobreposição de nicho alimentar de cinco espécies de felídeos, sendo elas: Leopardus tigrinus, L. wiedii, L. pardalis, Herpailurus yagouaroundi e Puma concolor. Para isso foram analisadas 460 amostras fecais e constatou-se que os mamíferos são os itens mais importantes na dieta dos felinos com destaque para a família Cricetidade, que ocorreram em 386 amostras, fato esperado principalmente para as espécies com menor porte. De maneira geral foram observados altos valores de sobreposição, sendo os valores mais altos encontrados para os pares L. tigrinus -L. pardalis e L. tigrinus-H. yagouaroundi. Apesar dos altos valores de sobreposição observados durante o período de amostragem, não se pode afirmar que esteja havendo competição por recursos, as espécies talvez ocupem nichos semelhantes, porém não idênticos, de modo a explorarem os recursos alimentares em diferentes proporções ao longo do tempo. Além disso, a abundância de roedores no período pode ter permitido essa alta sobreposição de nicho alimentar, fato que poderia ser investigado por meio da análise atual da dieta desses carnívoros, uma vez que não existem informações anteriores a este estudo para a região investigada.
Clifford, Vicki. "Psychotherapy is a Religious Movement rather than a scientific practice". Thesis, University of Edinburgh, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495083.
Testo completoNesti, Mark Stephen. "Anxiety and sport : time to ask what rather than why". Thesis, University of Hull, 1999. http://hydra.hull.ac.uk/resources/hull:8055.
Testo completoGomes, Eduardo Monteiro de Castro. "Modelo Rathie-Swamee: aplicações e extensão para modelo de regressão". Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/11/11134/tde-26072013-105052/.
Testo completoApplications and extensions to the Rathie-Swamee models are presented in this work. Proposed by Rathie and Swamee (2006), the Rathie-Swamee models were developed as a generalization to the logistic distribution. These models have great flexibility, assuming unimodal and multimodal shapes, and have some of its applications exemplified with bimodal data of shrimp fishing and geyser eruptions. By the use of simulations, the performance of different methods to obtain confidence intervals are compared. The extensions presented for the Rathie-Swamee models refer to the inclusion of covariates, creating regression models. These new regression models are fitted to fishing and eruption data, to exemplify some applications of the models. A new probability distribution is presented as the resulting distribution of quotients and products between independent random variables with Rathie-Swamee distributions. For this new distribution are presented some simulation results along with a table of quantiles for some percentage points of interest.
Silva, Francisca. "Sonaecom: returning to the old profitability strategy rather than growth…". Master's thesis, NSBE - UNL, 2010. http://hdl.handle.net/10362/10283.
Testo completoRaghunath, Rathan [Verfasser]. "A new physically motivated thermoviscoelastic model for filled elastomers / Rathan Raghunath". Magdeburg : Universitätsbibliothek, 2017. http://d-nb.info/1155824393/34.
Testo completoGrondin, Jean. "Hermeneutics is a Way of Doing Philosophy rather Than a School". Pontificia Universidad Católica del Perú - Departamento de Humanidades, 2012. http://repositorio.pucp.edu.pe/index/handle/123456789/112908.
Testo completoWarren, Elliot. "“Rather Than Be Suffered To Perish”/The Gendered Language Of Revolution". W&M ScholarWorks, 2020. https://scholarworks.wm.edu/etd/1616444297.
Testo completoThompson, Joshua David. "A Stepping Stone Rather Than a Destination: Analyzing Seamus Heaney's Pastoral". Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/73494.
Testo completoMaster of Arts
Wooster, Roland Peter. "Optimizing Response Time, Rather than Hit Rates, of WWW Proxy Caches". Thesis, Virginia Tech, 1996. http://hdl.handle.net/10919/36638.
Testo completoMaster of Science
Rathke, Fabian [Verfasser], e Christoph [Akademischer Betreuer] Schnörr. "Probabilistic Graphical Models for Medical Image Segmentation / Fabian Rathke ; Betreuer: Christoph Schnörr". Heidelberg : Universitätsbibliothek Heidelberg, 2015. http://d-nb.info/1180395042/34.
Testo completoPetersson, Agneta. "När språket stör snarare än stödjer (When language disturbs rather than supports)". Thesis, Malmö högskola, Lärarutbildningen (LUT), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-31314.
Testo completoWarhurst, Jannette. "DRUMBEAT© for arthritis “ a shared purpose” rather than a “lonely struggle”". Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2021. https://ro.ecu.edu.au/theses/2452.
Testo completoMartínez, Oró David Pere. "Sense passar-se de la ratlla la normalització dels consums recreatius de drogues". Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/129096.
Testo completoThe normalization of drug consumption has become a sociocultural phenomenon in the last twenty years in Western European countries. This normalization encompasses both the historic process and the present drug consumption scene. After the heroin crises of the eighties the pattern of drug consumption changed. The consumption of ecstasy, cocaine and cannabis spread among the young at parties, where consumption only played a secondary role in people’s lives. The new pattern of consumption moved away from the underground world of heroin and meant less problematic consequences. Over the last twenty years drug consumption has stopped causing alarm and an established cultural acceptance has come about. This means that for people involved in the world of drug consumption, taking drugs at a specific time and in a certain context is a functional act, which is accepted and does not bring about rejection. The present situation is a product of the process of normalization. The vast majority of consumption is compatible with having responsibilities as it causes few problems and the consumers are able to remain socially integrated. As a result, normalization is more and more accentuated and this happens even more so as a higher and higher number of the adult population, for generational reasons, has had satisfactory contact with drugs. As a result of the process of normalization, ideas about normalization have appeared. These delimit acceptable and normal consumption as well as that which is potentially problematic. Each individual consumer carries out a subjective interpretation of the idea of normalization in order to consume but avoid undesirable harm. This interpretation has been called the concept of regulation. The acceptance or rejection of consumption is a result of the idea of regulation, which continually evaluates consumption for pleasure. In order to consider consumption to be normal, the concept of regulation evaluates the context, time, frequency and the consequences it causes. The inter-connection of the factors must be compatible with the consumer’s responsibilities if consumption is to be kept within the limits of normality. If consumers practise problematic consumption, they will be labelled as problematic and they will have to modify their consumption to keep within normality. In the framework of the consumer society, apart from the concept of regulation, the desire to keep institutionalized helps the vast majority of consumers to avoid developing problems. The whole process of the normalization of drug consumption continues to be stigmatized in different formal contexts (workplace, family…) and this is why consumers have to know how to handle this. When faced with interaction, the vast majority choose to compromise, which means that they prefer to hide their consumption to avoid negative consequences, even though they consider the stigmatization to be out of proportion. Others put themselves in the situation of auto-stigmatization because while they themselves are consumers, they also consider drug consumption to be negative. And the last ones, the “transformers”, maintain a political commitment aimed at de-stigmatizing the consumers, considering that consumption forms part of society and the fact of consuming should not be hidden. They present themselves in society as consumers in spite of the possible stigmatization they might suffer. These are the ones who work towards the normalization of drug consumption. In the present scene of drug consumption, policies related to drugs continue with the prohibitive model. In spite of the introduction of risk and harm reduction as an effective practice to tackle consumption, moves towards the normalization of consumption continue to be only a minority. Therefore, in view of the present position of the normalization of consumption and the normality of consumers, a revision of drug policy has become necessary.
DAHLLÖF, AMANDA, e JULIA SVANSBO. ": Design rather than mass-production – analyzing the competitiveness of clothing-manufacturing in Rwanda". Thesis, Högskolan i Borås, Institutionen Textilhögskolan, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-18075.
Testo completoProgram: Textilekonomutbildningen
Carder, Maurice. "Challenging the English-only orthodoxy : linguistic pluralism recognition and diversity rather than assimilation". Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/10019957/.
Testo completoKoreeda, Satoshi. "Basal cell carcinoma cells resemble follicular matrix cells rather than follicular bulge cells". Kyoto University, 2004. http://hdl.handle.net/2433/147556.
Testo completoYen, Chin Stephanie. "Mercury Reduces Avian Reproductive Success through Direct Embryotoxicity Rather Than Altered Parental Behavior". W&M ScholarWorks, 2015. https://scholarworks.wm.edu/etd/1539626792.
Testo completoMarshall, Gregory Paul. "Neurospheres and multipotent astrocytic stem cells neural progenitor cells rather than neural stem cells /". [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0010047.
Testo completoTypescript. Title from title page of source document. Document formatted into pages; contains 97 pages. Includes Vita. Includes bibliographical references.
Viktorsson, Blom Linnéa. ""Sex? I'd rather have a cup of tea" : En maskulinitetsstudie av popfenomenet Boy George". Thesis, Linköpings universitet, Tema Genus, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-66263.
Testo completoLloyd, Justine, University of Western Sydney, of Arts Education and Social Sciences College e School of Cultural Histories and Futures. "I'd rather not be in Marrickville : aerial modernities and the domestication of the sublime". THESIS_CAESS_CHF_Lloyd _J.xml, 2000. http://handle.uws.edu.au:8081/1959.7/450.
Testo completoDoctor of Philosophy (PhD)
Marquis, Louis. "Why is there an international commercial uniform law rather than nothing?, a postmodern manifesto". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ61139.pdf.
Testo completoHardison, John W. "An expository sermon experiment on the virtue of courtship rather than traditional American dating". Theological Research Exchange Network (TREN), 2006. http://www.tren.com/search.cfm?p068-0568.
Testo completoRather, Alessa [Verfasser]. "Maarten van Heemskerck, die antike Überlieferung und die eigene. : Kunstproduktion als Erinnerungswerk. / Alessa Rather". Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1220288225/34.
Testo completoMiller, Nancy Carol. "Perceptions of motivation in developmental mathematics students : I would rather drill my own teeth /". Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004341.
Testo completoLloyd, Justine. "I'd rather not be in Marrickville : aerial modernities and the domestication of the sublime". Thesis, View thesis, 2000. http://hdl.handle.net/1959.7/uws:450.
Testo completoLloyd, Justine. "I'd rather not be in Marrickville : aerial modernities and the domestication of the sublime /". View thesis, 2000. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20050525.102244/index.html.
Testo completoBellman, Suzanne Beth. "I would rather be happy than right: Consumer impulsivity, risky decision making, and accountability". Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/2821.
Testo completoArmsworthy, Shelley L. "Effects of suspended bottom sediment on the feeding activity of the ascidian, Halocynthia pyriformis (Rathke)". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq23775.pdf.
Testo completoArmsworthy, Shelley L. "Effects of suspended bottom sediment on the feeding activity of the ascidian, Halocynthia pyriformis (Rathke)". Thesis, University of New Brunswick, 1996. http://hdl.handle.net/1882/495.
Testo completoSalama, Adnan Jameel. "Effects of food on growth, survival and food utilisation of the prawn Palaemon elegans (Rathke)". Thesis, University of Liverpool, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.291747.
Testo completoRathke, Theresa [Verfasser]. "Erworbene Muskelschwäche auf der Intensivstation – Elektronenmikroskopisches Korrelat in der Frühphase der kritischen Erkrankung / Theresa Rathke". Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2016. http://d-nb.info/1121007538/34.
Testo completoSmith, Patricia Anne Myers. ""Oppositions, rather than heroes" : an examination of dialectical principles in the work of Tom Stoppard". Thesis, University of Cape Town, 1987. http://hdl.handle.net/11427/23373.
Testo completoRathke, Hendrik [Verfasser]. "Validierung interventionell radiologischer Thermoablationsverfahren und ihre Visualisierung in der offenen 1 Tesla Magnetresonanztomographie / Hendrik Rathke". Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1148425462/34.
Testo completoCamats, Tarruella Núria. "Inestabilitat cromosòmica transgeneracional i radioprotecció en rata". Doctoral thesis, Universitat Autònoma de Barcelona, 2009. http://hdl.handle.net/10803/3823.
Testo completoAquesta tesi doctoral apropa la recerca bàsica a la clínica i els seus quatre objectius principals es centren en determinar l'existència dels efectes de la RI (raigs X), de mutàgens químics (afidicolina) i de possibles radioprotectors (triptorelina); així com la determinació de regions genòmicament inestables en l'espècie Rattus norvegicus.
La línia germinal de rates femella ha estat la base d'aquest estudi. No obstant, les cèl·lules objecte d'anàlisi han estat les cèl·lules somàtiques (fibroblasts fetals) descendents dels oòcits I fecundats de les femelles adultes dels diferents grups de tractament. D'aquesta manera, s'ha pogut estudiar la inestabilitat cromosòmica radioinduïda (RICI) transgeneracional amb diferents paràmetres citogenètics. Paral·lelament, s'ha realitzat un estudi reproductiu analitzant directament les femelles tractades.
S'ha demostrat que hi ha RICI transgeneracional. Els efectes de l'exposició a la RI d'oòcits I de rates femelles adultes es transmeten a la seva descendència. Aquesta RICI es presenta amb administració aguda i fraccionada de la dosi, i amb resultats semblants. Pel que fa a l'estudi reproductiu, no s'observa un efecte de la radiació amb els nostres paràmetres.
Els fibroblasts fetals de l'espècie R. norvegicus presenten inestabilitat cromosòmica espontània. Aquesta s'observa tant pels paràmetres quantitatius com pels qualitatius i es manté en tots els experiments que s'han fet.
L'administració del mutagen químic afidicolina als cultius de fibroblasts fetals de rata provoca dany citogenètic. Aquests efectes directes són clarament superiors quan el mutagen químic s'aplica a cèl·lules amb RICI transgeneracional indicant que aquesta en potencia els efectes.
L'anàleg agonista de l'hormona GnRH estudiat, la triptorelina, confereix radioprotecció als oòcits I dels fol·licles primordials de les femelles adultes irradiades. El grau de radioprotecció d'aquest fàrmac depèn del paràmetre analitzat, de la dosi i del tipus d'administració de la radiació ionitzant. En paràmetres citogenètics, la radioprotecció d'aquest anàleg és molt més pronunciada a dosi aguda (fins a un 44 %). Traslladant els nostres resultat a l'espècie humana, els nostres resultats en rata indicarien que els ovaris prepuberals i els ovaris de pacients adultes tractades amb aquest anàleg agonista de la GnRHa són més radioresistents que els ovaris de pacients adultes no tractades amb l'anàleg, confirmant estudis clínics i histològics anteriors.
La triptorelina també té un efecte protector enfront de la inestabilitat cromosòmica espontània, que es traduiria en una millora de la funció gonadal. Aquesta és evident quant als paràmetres citogenètics estudiats, i s'observa com a tendència pel que fa a les condicions reproductives de les femelles.
En relació a l'estudi de regions inestables, s'han identificat disset seqüències telomèriques intersticials classificades com a freqüents i molt freqüents i s'han caracteritzat set llocs fràgils induïts per l'afidicolina en fibroblasts fetals d'aquesta espècie. Ambdós tipus de seqüències estan implicats en processos evolutius i en esdeveniments d'inestabilitat cromosòmica de l'espècie.
Per acabar, s'ha determinat que les bandes cromosòmiques en rata no es trenquen a l'atzar, sinó que hi ha regions que pateixen més alteracions cromosòmiques que altres i que, per tant, són més inestables. Tenint en compte els efectes transgeneracionals de la RI, els efectes d'un mutagen químic, la inestabilitat cromosòmica espontània, els llocs fràgils i les seqüències telomèriques intersticials, les zones més inestables del cariotip de rata es localitzen en els cromosomes RNO1, RNO2 i RNO3. Les bandes cromosòmiques RNO1q22, RNO1q43, RNO2q32 i RNO3p12 són les més inestables del cariotip d'aquesta espècie.
Radiotherapy is one of the indicated treatments against cancer. In women, exposure to ionising radiation (IR) can induce a failure in the ovarian function. Therefore, there is a need for an exhaustive analysis of the X-ray effects in the female gonads and to search for a radio protector agent, so as to decrease these secondary effects.
This Ph.D. thesis attempts to infer conclusions from fundamental research and to apply this in a clinical capacity. Its four prime objectives are focused on the existence of effects of IR (X rays), of chemical mutagens (aphidicolin) and of possible radio protectors (triptorelin); and the determination of unstable genomic regions in the species Rattus norvegicus.
The basis of this study was the germinal line of female rats. However, the objects of analysis were the somatic cells (foetal fibroblasts) originating from the oocytes I of adult females from different treatment groups. In this way, transgenerational radiation-induced chromosomal instability (RICI) was studied with different cytogenetical parameters. At the same time, a reproductive study was performed directly on the treated females.
The existence of transgenerational RICI was demonstrated. Effects of the IR exposure of oocytes I from adult female rats are transmitted to their offspring. This RICI is present in acute and fractioned dosage administration, with similar results. Relating to the reproductive study, no radiation effect was seen with our parameters.
Foetal fibroblasts of R. norvegicus present spontaneous chromosomal instability. It is observed with both the quantitative and qualitative parameters and it is maintained in all the experiments performed.
Chemical mutagen aphidicolin administration to the foetal rat fibroblasts cultures causes cytogenetical damage. These direct effects are clearly superior when the chemical mutagen is applied to cells with transgenerational RICI, which indicates that RICI enhances its effects.
The GnRH hormone agonist studied, triptorelin, confers radioprotection to the oocytes I from the primordial follicles of adult irradiated females. The degree of radioprotection of this drug depends on the analysed parameter, and on the dose and type of administration of ionising radiation. Relating to cytogenetical parameters, radioprotection of this analogue is much more pronounced at an acute dose (up to 44%). If we relate our results to the human species, they would indicate that prepubertal ovaries and those from adult patients treated with this GnRH agonist are more radioresistant than those from non-treated adult patients. This would confirm former histological and clinical studies.
Triptorelin also affords protection from spontaneous chromosomal instability that would be translated into an improved gonadal function. This effect is evident relating to the cytogenetical parameters and it is observed as a tendency with respect to the reproductive conditions of the females.
Concerning to the study of unstable regions, seventeen interstitial telomeric-like sequences, classified as frequent and very frequent, and seven aphidicolin-induced fragile sites in rat foetal fibroblasts were detected. Both types of sequences are involved in evolutive processes and in chromosomal instability events of this species.
To finish, it was determined that chromosomal bands in rats do not break at random. There are chromosomal regions more unstable than others, as they suffer more chromosomal aberrations than others. The more unstable zones of the rat karyotype are located in chromosomes RNO1, RNO2 and RNO3, taking into account the transgenerational effects of IR, the effects of a chemical mutagen, the spontaneous chromosomal instability, fragile sites and interstitial telomeric-like sequences. Furthermore the more unstable chromosomal bands of this species are RNO1q22, RNO1q43, RNO2q32 and RNO3p12.
Lledó, García Rocio. "Estudio farmacocinético poblacional de antirretrovirales en rata". Doctoral thesis, Universitat de València, 2007. http://hdl.handle.net/10803/9762.
Testo completoSaquinavir and ritonavir belong to the protease inhibitors family, being currently used in combination in the management of AIDS. Saquinavir is characterized by a low and variable oral bioavailability which can be increased by the addition of ritonavir. Although the interaction between these drugs has already been reported in previous studies, to date, there is still lack of information regarding the roles of liver and intestine in their first pass metabolism. Thus, the aim of this study was to assess the pharmacokinetic profile for these drugs and their interaction, determining the participation of the metabolic organs.To achieve this aim, assays in rats subjected to the jugular vein cannulation were performed, administering different doses of the drugs by IV, IP and oral routes. The amount of drug in plasma samples was quantified by HPLC/UV technique.The population approach by means of NONMEM showed as main conclusions that the intestine plays the most important role in saquinavir first pass metabolism. In addition, it showed the interaction between these two drugs at the hepatic and intestinal biotransformation level, so that ritonavir inhibits saquinavir metabolism. As well as a displacement of ritonavir plasma protein binding produced when saquinavir is coadministered.
Melin, Susanna. "Thanks! You look rather dashing yourself. : A contrastive pragmatics investigation of Singaporean and American compliment responses". Thesis, Stockholms universitet, Engelska institutionen, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-104459.
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