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Letteratura scientifica selezionata sul tema "RANTES"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 20 febbraio 2023

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Articoli di riviste sul tema "RANTES"

1

Hoover, David M., Jeffrey Shaw, Zygmunt Gryczynski, Amanda E. I. Proudfoot, Tim Wells e Jacek Lubkowski. "The crystal structure of met-rantes: comparison with native rantes and aop-rantes". Protein & Peptide Letters 7, n. 2 (aprile 2000): 73–82. http://dx.doi.org/10.2174/092986650702221206112548.

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Abstract: Met-RANTES is a modified version of the chemokine RANTES, which has an additional amino acid at the amino terminus. To compare Met-RANTES with the native protein as well as with another antagonist, AOP RANTES, we have solved the structure of Met-RANTES at 1.6 A by X-ray crystallography and investigated the dimerization of all three proteins by fluorescence anisotropy. The dimerization of AOP-RANTES shows an altered aggregation profile. The delineation of slight differences in binding sulfate anions by Met- and AOP RANTES might be linked to specific yet different interactions between these proteins and glycosaminoglycans.

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2

McLean, Adam. "Regulation with RANTES". Lancet 343, n. 8891 (gennaio 1994): 189–90. http://dx.doi.org/10.1016/s0140-6736(94)90985-7.

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3

Pattison, James M., Peter J. Nelson e Alan M. Krensky. "The RANTES Chemokine". Clinical Immunotherapeutics 4, n. 1 (luglio 1995): 1–8. http://dx.doi.org/10.1007/bf03259067.

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4

Proudfoot, Amanda E. I., Raphaële Buser, Fredéric Borlat, Sami Alouani, Dulce Soler, Robin E. Offord, Jens-Michel Schröder, Christine A. Power e Timothy N. C. Wells. "Amino-terminally Modified RANTES Analogues Demonstrate Differential Effects on RANTES Receptors". Journal of Biological Chemistry 274, n. 45 (5 novembre 1999): 32478–85. http://dx.doi.org/10.1074/jbc.274.45.32478.

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5

Rutherford, Adam, e Jonathan Weitzman. "Split-personality RANTES mutation". Trends in Molecular Medicine 7, n. 1 (gennaio 2001): 12. http://dx.doi.org/10.1016/s1471-4914(00)01893-1.

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6

Hayashi, Kunio, Shosaku Nomura, Atsuko Mugitani, Minoru Hasegawa, Nobuhiko Uoshima, Takayuki Takubo, Masahiro Kami, Tsunehiko Komatsu, Tamae Hamaki e Toshio Shimokawa. "Chemokine RANTES (Regulated upon Activation, Normal T Cell Expressed and Secreted) in Multiple Myeloma and MGUS (Monoclonal Gammopathy of Undetermined Significance)." Blood 110, n. 11 (16 novembre 2007): 4756. http://dx.doi.org/10.1182/blood.v110.11.4756.4756.

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Abstract Introduction: Bone disease in patients with myeloma is the devastating complication. RANTES (CCR chemokine, Regulated upon Activation,Normal T Cell Expressed and Secreted) is involved in the bone remodeling that is made by coupled functions of osteoclasts and osteoblasts. Osteoclasts represent the RANTES receptor CCR1 and product RANTES. Osteoblasts express CCR1,3,4,5, and also product RANTES. Osteoblasts chemotaxicaly move to osteoclasts to repair the absorbed bone lesions (Shozo Yano et al., Endocrinology Vol.145, No.5, 2324–2335). The bone pathophysiology of multiple myeloma is the distortion of the well-balanced functions of osteoclast and osteobast. The change of RANTES may be representative of this distortion and the restoration of bone. Method: Blood samples were collected from 54 patients with Multiple Myeloma, 15 patients with MGUS, 41 from donors (30 healthy people or 11 people who have no bone disease). Plasma samples were separated and analyzed by ELISA to determine the levels of RANTES. Result: In healthy people, RANTES changes in proportion to ages with sexual difference. The value of RANTES is 155000pg/ml in20ys male, 51100pg/ml in 20ys female, 133000pg/ml in 40ys male and 78933 pg/ml in 40ys female. The difference of male and female becomes smaller and the value becomes nearly 60000pg/ml at sixty ages in male and female. Serum-bone specific alkaline phosphatase (BAP) is a biochemical indicator of bone turnover and urinary collagen type 1 cross-linked N-telopeptide (NTX) excretion normalized to creatinine (NTX/Cr) from urine sample is a bone resorption marker. At sixty ages, BAP and NTX/Cr become lower in accord with RANTES. In Myeloma cases, RANTES is about 20000pg/ml lower than the age-related value in female and about 75000pg/ml higher in male. After the treatment, RANRES increases in most of patients (both male and female) who have got response after chemotherapy. The rise of female is average 34566pg/ml but the rise of male is very small, average 5250pg/ml, because RANTES has already increased before chemotherapy. Beyond our expectation,RANTES of MGUS is almost the same as Myeloma. Discussion: The bone remodeling activity of male is higher than female and may be easily induced by the chance of bone absorption. The data suggest that tumor growth suppression produces the recovery of the remodeling. The value of RANTES of MGUS indicates why some patients with MGUS have the punched-out lesions like Myeloma. Conclusion: This study has turned out for the first time that RANTES is associated with the bone pathophysiology of multiple myeloma and MGUS.

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7

Rodríguez-Frade, José M., Antonio J. Vila-Coro, Ana Martín, Marta Nieto, Francisco Sánchez-Madrid, Amanda E. I. Proudfoot, Timothy N. C. Wells, Carlos Martínez-A e Mario Mellado. "Similarities and Differences in RANTES- and (AOP)-RANTES–triggered Signals: Implications for Chemotaxis". Journal of Cell Biology 144, n. 4 (22 febbraio 1999): 755–65. http://dx.doi.org/10.1083/jcb.144.4.755.

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Chemokines are a family of proinflammatory cytokines that attract and activate specific types of leukocytes. Chemokines mediate their effects via interaction with seven transmembrane G protein–coupled receptors (GPCR). Using CCR5-transfected HEK-293 cells, we show that both the CCR5 ligand, RANTES, as well as its derivative, aminooxypentane (AOP)- RANTES, trigger immediate responses such as Ca2+ influx, receptor dimerization, tyrosine phosphorylation, and Gαi as well as JAK/STAT association to the receptor. In contrast to RANTES, (AOP)-RANTES is unable to trigger late responses, as measured by the association of focal adhesion kinase (FAK) to the chemokine receptor complex, impaired cell polarization required for migration, or chemotaxis. The results are discussed in the context of the dissociation of the late signals, provoked by the chemokines required for cell migration, from early signals.

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8

Mack, Matthias, Bruno Luckow, Peter J. Nelson, Josef Cihak, Graham Simmons, Paul R. Clapham, Nathalie Signoret et al. "Aminooxypentane-RANTES Induces CCR5 Internalization but Inhibits Recycling: A Novel Inhibitory Mechanism of HIV Infectivity". Journal of Experimental Medicine 187, n. 8 (20 aprile 1998): 1215–24. http://dx.doi.org/10.1084/jem.187.8.1215.

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CCR5, a chemokine receptor expressed on T cells and macrophages, is the principal coreceptor for M-tropic HIV-1 strains. Recently, we described an NH2-terminal modification of the CCR5 ligand regulated on activation, normal T cell expressed and secreted (RANTES), aminooxypentane-RANTES (AOP-RANTES), that showed potent inhibition of macrophage infection by HIV-1 under conditions where RANTES was barely effective. To investigate the mechanism of AOP-RANTES inhibition of HIV infectivity we examined the surface expression of CCR5 using a monoclonal anti-CCR5 antibody, MC-1. We demonstrate that AOP-RANTES rapidly caused >90% decrease in cell surface expression of CCR5 on lymphocytes, monocytes/ macrophages, and CCR5 transfected Chinese hamster ovary (CHO) cells. RANTES also caused a loss of cell surface CCR5, although its effect was less than with AOP-RANTES. Significantly, AOP-RANTES inhibited recycling of internalized CCR5 to the cell surface, whereas RANTES did not. When peripheral blood mononuclear cells are cultured for prolonged periods of time in the presence of RANTES, CCR5 expression is comparable to that seen on cells treated with control medium, whereas there is no CCR5 surface expression on cells cultured in the presence of AOP-RANTES. Immunofluorescence indicated that both AOP-RANTES and RANTES induced downmodulation of cell surface CCR5, and that the receptor was redistributed into endocytic organelles containing the transferrin receptor. When RANTES was removed, the internalized receptor was recycled to the cell surface; however, the receptor internalized in the presence of AOP-RANTES was retained in endosomes. Using human osteosarcoma (GHOST) 34/CCR5 cells, the potency of AOP-RANTES and RANTES to inhibit infection by the M-tropic HIV-1 strain, SF 162, correlated with the degree of downregulation of CCR5 induced by the two chemokines. These differences between AOP-RANTES and RANTES in their effect on receptor downregulation and recycling suggest a mechanism for the potent inhibition of HIV infection by AOP-RANTES. Moreover, these results support the notion that receptor internalization and inhibition of receptor recycling present new targets for therapeutic agents to prevent HIV infection.

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Terao, Satoshi. "Chemokine RANTES in brain infarction". Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism) 28, n. 2 (2017): 327–31. http://dx.doi.org/10.16977/cbfm.28.2_327.

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10

Graziano, Frank M., Ellen B. Cook e James L. Stahl. "Cytokines, Chemokines, RANTES, and Eotaxin". Allergy and Asthma Proceedings 20, n. 3 (1 maggio 1999): 141–46. http://dx.doi.org/10.2500/108854199778553055.

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Più fonti

Tesi sul tema "RANTES"

1

Fish, Richard James. "RANTES derivatives and CCR5". Thesis, University of York, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369362.

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2

PORTAS, DANUSA DEPES. "IMÁGENES MI(G)RANTES". PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2014. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=29990@1.

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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO
COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO
PROGRAMA DE SUPORTE À PÓS-GRADUAÇÃO DE INSTS. DE ENSINO
Esta tese se propõe à construção de uma perspectiva teórica que observe as aporias e antinomias reveladas pelo regime contemporâneo das imagens. As imagens constituem um ponto de peculiar fricção e desconforto junto às ciências humanas, não só como um tópico de estudo, mas como característica cultural divisada. Esse campo vem se definindo de modo interdisciplinar e alargando sua perspectiva na linha de pesquisa denominada Cultura Visual (Visual Culture). T.W. Mitchell fala de um pictorial turn ou inclusive um visual turn que estariam relacionados com um enfoque apoiado por infiltrações mútuas entre duas epistemologias, a visual e a linguística, o que problematiza a premissa naturalizada de se entender o ato interpretativo como o núcleo da competência profissional dos especialistas de nossa área. As imagens ou as visualidades demandam seus próprios modos de análise e exigem do investigador um tratamento operacional e uma consequente definição de termos que suportem suas particularidades. Ao tópico, acrescenta-se a reinstalação warburguiana que coincide, não por acaso, com este giro e induz à pesquisa fundamental atenção em algumas vertentes heurísticas do trabalho de Aby Warburg, pensador alemão que ao princípio do século XX explorou um campo de inter-relações entre a antropologia, imagens e arte. No exemplo do projeto Der Bilderatlas Mnemosyne, antecipa-se a reflexão atual. As proposições de Warburg, bem como as pesquisas teóricas de importante exegeta de sua obra George Didi-Huberman, buscam entender qualquer imagem como um cruzamento de múltiplas migrações – tanto em seu modelo de tempo, Nachleben, como em seu modelo de sentido, Pathosformel – e oferecem ferramenta metodológica central a essa investigação. A partir de uma moldura teórica sistêmica, a tese enfoca o projeto de artistas visuais, como Harun Farocki, cujo trabalho realiza uma arqueologia do saber visual através da prospecção e montagem de tempos heterogêneos, mediante imagens animadas por uma energia expressiva e por uma enorme espessura histórico-cultural. A análise desses agenciamentos procura delinear sua inserção ambivalente na cena contemporânea em que o sistema de comunicação impõe-se como força estruturante de novas formas de socialização através de práticas culturais e tecnologia, com amplas consequências para o campo humanístico, oferecendo enfoques inovadores à dinâmica de articulação de formas de vida e de cultura com as tecnologias de imediação. A dimensão transnacional do tráfico e da produção de imagens situa a imagem no centro dos debates sobre o papel da representação nas culturas globais. Estas questões poderiam cumprir-se em dois problemas fundamentais, a hibridação dos campos disciplinares e a relação entre a imagem e o arquivo com relação à memória, à história, à justiça. No horizonte destes problemas, o objetivo da tese é distinguir o papel constitutivo das sobrevivências (Nachleben) na dinâmica da imaginação ocidental e as funções politicas dos agenciamentos memorialísticos de que se revelam portadores.
Esta tesis se propone a la construcción de una perspectiva teórica que amaitine las aporías y antinomias reveladas por el régimen contemporáneo de imágenes. Las imágenes son un punto de fricción y desasosiego junto de las ciencias humanas, no sólo como un tema de estudio, sino como característica cultural percebida. Este campo se ha definido de manera interdisciplinaria y amplía su perspectiva a una línea de investigación denominada Cultura Visual (Visual Culture). T. W. Mitchell habla de un pictorial turn o incluso un visual turn que estarían relacionados con un enfoque respaldado por infiltraciónes recíprocas entre dos epistemologías, visual y lingüística, lo que cuestiona la premisa naturalizada de comprender el acto interpretativo como el núcleo de la competencia profesional de los especialistas en nuestra área. Las imágenes o visualidades exigen sus propios modos de análisis y requieren del investigador un tratamiento operativo y una consecuente definición de términos que sostenga sus particularidades. Al tema, se suma la reinstalación warburguiana que coincide, no por causalidad, con este giro e induce a investigación fundamental atención sobre la figura y algunas vertientes heurística del trabajo de Aby Warburg, pensador alemán que exploró a principios del siglo XX, un campo de interrelaciones entre antropología, imágenes y arte. En el exemplo Der Bilderatlas Mnemosyne, se anticipa todo una reflexión actual. Las proposiciones de Warburg, así como la investigación teórica de importante exégeta de su obra George Didi-Huberman buscan entender cualquier imagen como un cruce de múltiples migraciones – tanto en su modelo de tiempo, Nachleben, como en su modelo de sentido, Pathosformel – y ofrecen herramienta metodológica central a esta investigación. Desde un marco teórico sistémico, la tesis enfoca el proyecto de artistas visuales, como Harun Farocki, cuyo trabajo realiza una arqueología del saber visual a través de la prospección y montaje de tiempos heterogéneos, mediante imágenes animadas por una potencia expresiva y por un enorme espesor histórico-cultural. La análisis de estos agenciamientos busca delinear su inserción ambivalente en la escena contemporánea, donde se impone el sistema de comunicación como una fuerza estructurante de nuevas formas de socialización a través de prácticas culturales y tecnología, con amplias consecuencias para el campo humanístico, ofrecendo enfoques innovadores a dinámica de articulación de formas de vida y de cultura con las tecnologías de inmediación. La dimensión transnacional del tráfico y la producción de imágenes situa la imagen en el centro de los debates sobre el papel de la representación en las culturas globales. Estas cuestiones podrían cumplirse en dos problemas fundamentales, la hibridación de los campos disciplinarios, la relación entre la imagen y el archivo con respecto a la memoria, la historia, la justicia. En el horizonte de estos problemas, el objetivo de este trabajo consiste en distinguir el papel constitutivo de supervivencias (Nachleben) en la dinámica de la imaginación occidental y las funciones políticas de los agenciamientos de que se revelan portadores.

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3

Turner, Lynn. "RANTES and T lymphocytes". Thesis, University of Bath, 1996. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307048.

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4

Machado, Renes de Resende. "Mediadores envolvidos na resposta febril induzida pela RANTES". Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/60/60138/tde-13022009-160445/.

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Em estudo anterior, observamos que o Met-RANTES, antagonista de receptores CCR1 e CCR5 para quimiocinas, injetado pela via endovenosa (i.v.) reduziu a resposta febril induzida pelo lipopolissacarídeo (LPS) de E. coli, demonstrando o envolvimento da quimiocina RANTES (Regulada sob ativação, expressa e secretada por células T normais) nesta resposta. Além disso, a injeção intrahipotalâmica (i.h.) da RANTES dose-dependentemente aumentou a temperatura corporal de ratos, o qual foi caracterizado como febre, pois foi acompanhada de redução da temperatura da cauda, uma resposta termorregulatória para retenção de calor. Observamos também, que a RANTES aumenta a concentração de prostaglandinas no fluido cerebroespinhal (CSF) e que a febre por ela induzida é sensível aos inibidores não-seletivos para as ciclooxigenases e seletivo para COX-2 (Machado et al., 2007). No presente estudo, aprofundamos a investigação sobre os mediadores, incluindo as prostaglandinas, envolvidos na resposta febril induzida pela RANTES. Verificamos que o paracetamol reduziu, enquanto o diclofenaco de sódio aboliu a resposta febril induzida pela RANTES. Ainda, a injeção i.h. da RANTES promoveu significativa expressão do RNAm para COX-2 no hipotálamo, confirmando ser a COX-2 a enzima responsável pela síntese de prostaglandinas envolvidas no efeito pirogênico desta quimiocina. Através da administração de corante in situ e de cortes histológicos, pode-se averiguar o trajeto da cânula bem como a profundidade alcançada pela agulha durante a injeção na área pré-óptica hipotalâmica anterior (AH/POA). Padronizamos a dose do Met-RANTES (i.h.) que não seria capaz de alterar a temperatura retal dos animais. Posteriormente, avaliou-se o efeito de diferentes doses do Met-RANTES, administrado via intrahipotalâmica, na resposta febril induzida pelo LPS ou pela RANTES. Entretanto, nas doses administradas o pré-tratamento com o antagonista não foi capaz de reduzir a febre induzida por ambos os estímulos. Contudo, o Met-RANTES (i.v.) reduziu a febre induzida pelo TNF-alfa (i.h.), reproduzindo resultados anteriores. O pré-tratamento com Met-RANTES (i.v.) não modificou a febre induzida pela injeção central de interleucina (IL)-6, fator liberador de corticotropina (CRF) e bradicinina (BK). Adicionalmente, a injeção de LPS (i.v.) ou TNF-alfa (i.h.) elevou a concentração da RANTES no tecido hipotalâmico. Antalarmina (antagonista de receptores CRF1) e alfa-helical CRF9-41 (antagonista de receptores CRF1 e CRF2) que reduziram a febre induzida pelo CRF, não alteraram a febre induzida pela administração i.h. da RANTES. O antagonista de receptores B1 (DALBK) que reduziu a segunda fase da resposta febril induzida pela BK, não foi capaz de modificar a febre induzida pela RANTES. Da mesma forma, o antagonista de receptores B2 (Hoe-140) que reduziu a resposta febril induzida pela BK durante todo o período de experimentação, não modificou a febre promovida pela RANTES. Por outro lado, verificamos que o anticorpo anti-IL-6 administrado i.h. reduziu a febre induzida pela IL-6 e pela RANTES. Ainda, a injeção de LPS (i.v.) ou RANTES (i.h.) elevou a concentração de IL-6 no CSF, mas não de IL-1 e TNF-. A RANTES promoveu ativação do fator nuclear-kB (NF-kB) e aumentou a expressão do RNAm para as citocinas IL-1beta, TNF-alfa e IL-6 no hipotálamo dos animais. O pré-tratamento com Met-RANTES reduziu, na 2,5 e 6 h, a neutrofilia induzida pelo LPS. Em síntese, nossos resultados demonstram que durante a resposta febril induzida pelo LPS, este induz a síntese de TNF-alfa o qual promove a síntese da quimiocina RANTES que, ativando os receptores CCR1 e CCR5 promove a transmigração do NF-kB do citoplasma para o núcleo e a subseqüente síntese de IL-6 e de COX-2, esta última, a responsável pela síntese de prostaglandina E2 (PGE2), um dos mediadores finais da resposta febril induzida pelo LPS. Além disso, a RANTES parece ser um mediador da resposta de fase aguda, uma vez que, promove dois sinais importantes desta resposta, febre e neutrofilia.
We showed before that Met-RANTES, CCR1 and CCR5 receptor antagonist, intravenously injected (i.v.) reduced fever induced by lipopolysaccharide (LPS, E. coli), demonstrating the involvement of RANTES (Regulated on activation, normal T cells expressed and secreted) in this response. Also, intrahypothalamic (i.h.) injection of RANTES dose-dependently increased body temperature of rats, this increase was characterized as fever, because it was accompanied of a reduction in the tail skin temperature, a thermoregulatory response for heat retention. We also verified that RANTES increased the concentration of prostaglandin (PG)E2 in the cerebrospinal fluid (CSF), which was sensible to non-selective and selective blockers to cyclooxygenase (COX)-2 (Machado et al., 2007). In the present study, it was investigated which others mediators, including prostaglandins, are involved in the RANTES-induced fever. The effect of paracetamol and sodium diclofenac on fever induced by RANTES was also investigated. Paracetamol reduced, while sodium diclofenac abolished the RANTES-induced fever. The intrahypothalamic (i.h.) RANTES injection promoted a significant COX-2 mRNA expression in the hypothalamus, confirming the role of the COX-2 enzyme in the synthesis of prostaglandin involved in the pyrogenic effect of this chemokine. Through administration of dye in situ and histological analyses, we confirmed that the injection in the preoptic area of the anterior hypothalamus (AH/POA) was correct. Subsequently, we evaluated the effect of different doses of Met-RANTES (i.h.) in the fever induced by both LPS and RANTES. Centrally injected, Met-RANTES did not modify the fever induced by LPS or RANTES. On the other hand, Met-RANTES (i.v.) reduced TNF-alpha-induced fever, but did not modify the fever induced by interleukin (IL)-6, corticotrophin releasing factor (CRF) and bradykinin (BK). Additionally, the injection of LPS (i.v.) or TNF-alpha (i.h.) increased RANTES concentration in the hypothalamus. Antalarmin (a CRF receptor 1 antagonist) and alpha-helical CRF9-41 (CRF 1 and 2 receptor antagonist) that reduced CRF-induced fever did not modify the fever induced by RANTES (i.h.). DALBK (bradykinin B1 receptor antagonist) that reduced the second phase of BK-induced fever did not modify RANTES-induced fever. In the same way, Hoe-140 (bradykinin B2 receptor antagonist) that reduced the fever induced by BK during the whole period of observation, did not modify RANTES-induced fever. On the other hand, we verified that anti-rat IL-6 antibody (i.h.) reduced the fever induced by both IL-6 and RANTES. In addition, the administration of LPS (i.v.) or RANTES (i.h.) increased the CSF IL-6 concentration, but not of IL-1 and TNF-. RANTES promoted nuclear factor-kB (NF-kB) activation and increased IL-1beta, TNF-alpha and IL-6 mRNA expression in the hypothalamus. Pretreatment of the animals with Met-RANTES reduced the LPS-induced neutrophilia. In synthesis, our results suggest that in the fever induced by LPS, RANTES induces TNF- synthesis, which promotes the synthesis of RANTES that, activating CCR1/CCR5 receptors, promotes NF-kB transmigration of cytoplasm to the nucleus and subsequent synthesis of IL-6 and COX-2. The latter, in turn, is responsible by (PGE2) synthesis, one of the final mediators of the febrile response induced by LPS. Moreover, RANTES seem to be a mediator of the acute phase response since it promoted two important signs of this response, fever and neutrophilia.

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5

Campbell, Emma Michelle. "The role of RANTES in guinea pig inflammatory responses". Thesis, University of Bath, 1996. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362252.

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6

Charni, Faten. "Rôles de la chimiokine RANTES/CCL5 dans la carcinogenèse hépatique". Paris 13, 2011. http://www.theses.fr/2011PA132043.

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La liaison de la chimiokine RANTES/CCL5 à son récepteur couplé aux protéines G, CCR1, entraîne des effets pro-tumoraux sur les cellules d’hépatome humain Huh7. Notre étude indique également l’implication de deux protéoglycannes à héparane sulfate, le syndécanne-1 et le syndécanne-4 dans les effets chimiotactiques et l’étalement des cellules d’hépatome humain Huh7, HepG2 et Hep3B induits par RANTES/CCL5. Le ciblage de l’interaction entre chimiokine et syndécanne, aboutissant à la modulation des effets cellulaires médiés par RANTES/CCL5, pourrait représenter une nouvelle approche thérapeutique du carcinome hépatocellulaire (CHC). Nous avons également développé parallèlement un axe de recherche bioclinique consistant en l’étude de l’influence de deux polymorphismes affectant le gène codant pour la chimiokine RANTES/CCL5 (RANTES/CCL5 C-28G et RANTES/CCL5 G-403A) dans l’évolution de maladies hépatiques chroniques d’étiologie alcoolique ou virale C vers le CHC. Nous avons démontré que l’allèle A-403 du dimorphisme RANTES/CCL5 G-403A semble protéger les patients atteints de cirrhose alcoolique du risque de développer un CHC. Au contraire, le dimorphisme RANTES/CCL5 C-28G ne semble pas avoir d’effets chez nos deux cohortes de patients
In addition to their physiologic effects in inflammation and angiogenesis, chemokines are involved in cancer pathology. This study demonstrates that chemokine RANTES/CCL5 induce the migration, invasion and spreading of human hepatoma Huh7, HepG2 and Hep3 cells. This study also indicates that the receptor CCR1 and the two membrane heparan sulfate proteoglycans, syndecan-1 and syndecan -4, may be required for HepG2, Hep3B and Huh7 cells migration, invasion and spreading induced by the chemokine. Targeting the RANTES/CCL5-glycosaminoglycan interaction could be a new therapeutic approach for HCC. We have also developed a parallel line of bio-clinical research consisting of study of the influence of two functional genetic polymorphisms in the RANTES/CCL5 promoter RANTES/CCL5 C-28G and RANTES/CCL5 G-403A on the risk of HCC occurrence in patients with alcoholic or HCV-related cirrhosis. RANTES/CCL5 C-28G and G-403A promoter dimorphisms and RANTES/CCL5 serum levels were assessed in 243 HCV-infected patients and 253 alcoholic patients, included at the time of diagnosis of cirrhosis and prospectively followed-up. This study suggests an influence of the chemokine RANTES/CCL5 G-403A dimorphism on the occurrence of HCC in patients with alcoholic cirrhosis

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Marfaing, Koka Anne. "Role de la chemokine rantes dans la reaction d'hypersensibilite retardee". Paris 11, 1997. http://www.theses.fr/1997PA11T023.

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Frink, Michael. "Zur Funktion des CC-Chemokins CCL5/RANTES bei der Immunkomplex-Glomerulonephritis". Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-17119.

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9

Pattison, James Michael. "Aspects of the function and regulation of the human chemokine RANTES". Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308849.

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Chaffey, Benjamin T. "Investigations into the biological functions of the CC chemokine CCL5/RANTES". Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413418.

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Libri sul tema "RANTES"

1

Ranter. Lenton, Nottingham: Slow Dancer, 1985.

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Rants. Wooster, Ohio: Wooster Book, 2002.

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F, Sheehan Thomas. Mountain ranges. Vero Beach, Fl: Rourke Pub., 2008.

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Morris, Neil. Mountain ranges. Austin, Tex: Raintree Steck-Vaughn, 1997.

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Harvey, Bruce, e Trixie Harvey. Waitakere Ranges: Ranges of inspiration : nature, history, culture. Waitakere City: Waitakere Ranges Protection Society, 2006.

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1953-, Miller Dennis, a cura di. The rants. New York: Doubleday, 1996.

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Idaho mountain ranges. Helena, Mont: American Geographic Pub., 1986.

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Nevada mountain ranges. Helena, MT: American & World Geographic Pub., 1992.

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J, Soldin Steven, Brugnara Carlo e Hicks Jocelyn M, a cura di. Pediatric reference ranges. 3^a ed. Washington, DC: AACC Press, 1999.

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Colorado mountain ranges. Helena and Billings, Mont: Falcon Press, 1986.

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Capitoli di libri sul tema "RANTES"

1

Martemyanov, Kirill A., Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow et al. "RANTES". In Encyclopedia of Signaling Molecules, 1589. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_101145.

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Gewies, Andreas, Jürgen Ruland, Alexey Kotlyarov, Matthias Gaestel, Shiri Procaccia, Rony Seger, Shin Yasuda et al. "MIP-1α/RANTES". In Encyclopedia of Signaling Molecules, 1081. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100807.

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Michie, C. A., K. S. Soo, T. Schall, L. G. Bobrow e P. C. L. Beverley. "In Vivo Studies of Rantes and the Recruitment of Lymphocytes to Inflammatory Sites". In Advances in Experimental Medicine and Biology, 217. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2952-1_67.

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Bedke, J., T. Stojanovic, H. J. Gröne, M. Heuser, L. Scheele, A. E. Proudfoot, H. Becker, P. M. Markus e M. Hecker. "Met-RANTES verbessert die mikrokapilläre Perfusion während der akuten Abstoßung am Dünndarmtransplantat der Ratte". In Chirurgisches Forum 2002, 271–73. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-642-56158-0_70.

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Schmidt, J., H. M. Hu, R. Hatz, B. A. Fox, F. W. Schildberg, N. van den Engel e H. Winter. "Die Chemokine Rantes, KC und MCP-1 spielen eine mögliche Rolle bei T-Zell vermittelter Tumorregression". In Zurück in die Zukunft, 512–13. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-642-55611-1_330.

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Zischek, C., H. Niess, I. Ischenko, M. Eichhorn, K. W. Jauch, P. Nelson e C. J. Bruns. "Targeted stem cell based RANTES/TK suicide gene-therapy in a murine pancreatic cancer tumour model". In Deutsche Gesellschaft für Chirurgie, 3–5. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00625-8_2.

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Schmidt, J., H. M. Hu, R. A. Hatz, B. A. Fox, F. W. Schildberg, N. K. van den Engel e H. Winter. "Die Chemokine RANTES, KC und MCP-1 spielen eine mögliche Rolle bei T-Zell vermittelter Tumorregression". In Deutsche Gesellschaft für Chirurgie, 37–39. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-642-19024-7_11.

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Winter, H., J. Schmidt, C. Pöhlein, N. K. van den Engel, T. Seher, H. M. Hu, B. A. Fox, K. W. Jauch e R. A. Hatz. "Die Chemokine RANTES, MIP-1α und MIP-1ß spielen eine entscheidende Rolle bei T-Zell vermittelter Tumorregression". In Deutsche Gesellschaft für Chirurgie, 45–47. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-642-18547-2_14.

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9

Eckstein, Wolfgang. "Ranges". In Computer Simulation of Ion-Solid Interactions, 121–41. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-73513-4_10.

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Taub, Dennis D., Andrew R. Lloyd, Ji-Ming Wang, Joost J. Oppenheim e David J. Kelvin. "The Effects of Human Recombinant MIP-1α, MIP-1β, and Rantes on the Chemotaxis and Adhesion of T Cell Subsets". In Advances in Experimental Medicine and Biology, 139–46. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2952-1_15.

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Atti di convegni sul tema "RANTES"

1

Zhao, W., RL Toonkel, M. Sole, AC Borczuk e CA Powell. "Lung Adenocarcinoma Invasion by TGFBRII Deficient Cells Requires RANTES/CCR5." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5133.

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Perry, MM, AE Williams, HL Svensson e MA Lindsay. "The Transcriptional Regulation of the Pro-Inflammatory Chemokines; IL-8 and RANTES and the Gene; miR-146a." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1953.

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Mansfield, James, Chuanbo Xu e Rachel Gonzalez. "Abstract 379: Evaluating tissue expression of RANTES with subtype specific breast cancer biomarkers found elevated in plasma." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-379.

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Karakasheva, Tatiana A., Monica Soni, Todd Waldron e Anil K. Rustgi. "Abstract 2383: IL-6 and RANTES mediate the cross-talk between tumor cells and CAFs in the esophageal tumor microenvironment". In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-2383.

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Van Horn, Robert, Tinggui Yin, Xiaoyi Zhang, Chunping Yu, Youyan Zhang, Xue-Qian Gong, Sean Buchanan et al. "Abstract B229: TBKI kinase inhibition blocks RANTES secretion and exhibits minimal tumor growth inhibition in oncogenic Ras-driven tumor models." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Oct 19-23, 2013; Boston, MA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1535-7163.targ-13-b229.

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Gallo, Marianna, Daniela Frezzetti, Nicola Normanno e Antonella De Luca. "Abstract 4343: Effects of the co-expression of RANTES and IL-6 on the transformed phenotype of breast cancer cells". In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-4343.

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Karatayli, E., SN Weber, SC Karatayli, RA Hall, S. Dooley e F. Lammert. "Il-2, Il-22 and Rantes upregulation in a new mouse model of bacterial infection related acute-on-chronic liver injury". In 36. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3402252.

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Venkatesh, Amritha Kalyani, Michelle Pate e Fabian Benencia. "Abstract 1333: Upregulation of chemokines including RANTES/CCL5 upon Toll-like receptor 3 activation in breast cancer: Association with leukocyte infiltration". In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-1333.

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Krynskiy, Sergey, Irina Malashenkova, Nikita Hailov, Daniil Ogurtsov, Ekaterina Chekulaeva, Albina Manyurova, Elena Ponomareva, Svetlana Gavrilova e Nikolay Didkovsky. "LEVELS OF IL-15 CYTOKINE, RANTES AND CXCL-10 CHEMOKINES DEPENDING ON APOE GENOTYPE IN PATIENTS WITH AMNESTIC MILD COGNITIVE IMPAIRMENT". In XVII INTERNATIONAL INTERDISCIPLINARY CONGRESS NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY. LCC MAKS Press, 2021. http://dx.doi.org/10.29003/m2186.sudak.ns2021-17/214-215.

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Karatayli, E., SN Weber, SC Karatayli, RA Hall, S. Dooley e F. Lammert. "Upregulation of Il-22 and Rantes in a new mouse model of bacterial infection related acute-on-chronic liver injury (BI-ACLI)". In Viszeralmedizin 2019. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1695256.

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Rapporti di organizzazioni sul tema "RANTES"

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McDonough, M. R., e P. S. Simony. Geology of the northern Selwyn Range, western Main Ranges, Rocky Mountains, British Columbia: Preliminary Report. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1986. http://dx.doi.org/10.4095/120433.

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Enscore, Susan, Dawn Morrison, Adam Smith e Sunny Adams. Fort Huachuca ranges : a history and analysis. Engineer Research and Development Center (U.S.), dicembre 2021. http://dx.doi.org/10.21079/11681/42720.

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Fort Huachuca Environmental and Natural Resources Division (ENRD) sent funds to ERDC-CERL to develop a historic context that assists Fort Huachuca personnel in identifying the likely history and provenance of numerous historic range features located across Fort Huachuca's training lands. The historic context will be used by cultural resources personnel to evaluate and manage the resources appropriately. Various historic training range features (e.g., structures, fragments, and items left over from previous activities) are located across the ranges of Fort Huachuca, representing its long and storied history. To help identify and catalog these features, ERDC-CERL conducted a field survey of the training ranges in 2016 in or-der to photograph the historic range features. Forty-one historic range features were identified. Researchers conducted archival research, literature reviews, and image analysis of historic and current maps and photographs to identify the 41 historic range features and place them within a chronological context of Fort Huachuca's training ranges. The report concludes with guidance on how to identify and associate sites and features within the overall historic training range chronology and evaluate them appropriately for significance and National Register of Historic Places (NRHP) eligibility.

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Irwin, Jeffrey D., e Heather L. McDonald. Range Riders and Game Wardens: A Brief History of Fort Bragg's Forest Ranger Program. Fort Belvoir, VA: Defense Technical Information Center, luglio 2006. http://dx.doi.org/10.21236/ada463598.

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Hernandez, J., R. Smith, V. Petty e J. Lock. Development of Range Design Elements and Quality Control/Quality Assurance Guidance to Reduce Maintenance Requirements on Training Ranges. Fort Belvoir, VA: Defense Technical Information Center, novembre 2006. http://dx.doi.org/10.21236/ada460751.

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Svendsen, Niels G., Prasanta K. Kalita e Dick L. Gebhart. Evaluation of Soil Loss and Erosion Control Measures on Ranges and Range Structures at Installations in Temperate Climates. Fort Belvoir, VA: Defense Technical Information Center, giugno 2006. http://dx.doi.org/10.21236/ada467835.

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Chapman, Elaine G., James C. Barnard, Frederick C. Rutz, Mikhail S. Pekour, Jeremy P. Rishel e William J. Shaw. Dust Plume Modeling from Ranges and Maneuver Areas on Fort Bliss and the White Sands Missile Range: Final Report. Office of Scientific and Technical Information (OSTI), maggio 2009. http://dx.doi.org/10.2172/957366.

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Drummond, J. Safety Precautions for Test Ranges. Fort Belvoir, VA: Defense Technical Information Center, marzo 1999. http://dx.doi.org/10.21236/ada476729.

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Meade, Roger. Ranger. Office of Scientific and Technical Information (OSTI), settembre 2021. http://dx.doi.org/10.2172/1821340.

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ARMY TRAINING SUPPORT CENTER FORT EUSTIS VA. Training Ranges in the 21st Century. Fort Belvoir, VA: Defense Technical Information Center, aprile 2003. http://dx.doi.org/10.21236/ada413536.

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Covey, C., e S. Klein. Plausible ranges of observed TOA fluxes. Office of Scientific and Technical Information (OSTI), giugno 2010. http://dx.doi.org/10.2172/1049465.

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