Bibliografie tematiche / Pyridine phosphonate

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Letteratura scientifica selezionata sul tema "Pyridine phosphonate"

Autore: Grafiati

Pubblicato: 1 marzo 2025

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Articoli di riviste sul tema "Pyridine phosphonate"

Kolodiazhna, O. O., E. V. Gryshkun, A. O. Kolodiazhna, S. Yu Sheiko e O. I. Kolodiazhnyi. "Catalytic phosphonylation of C=X electrophiles". Reports of the National Academy of Sciences of Ukraine, n. 12 (dicembre 2020): 75–84. http://dx.doi.org/10.15407/dopovidi2020.12.075.

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A method for the catalytic phosphonylation of C = X electrophiles has been developed. Pyridinium perchlorate is an effective catalyst for the phosphonylation reaction of trialkyl phosphites with various electrophiles C = X (X = O, S, N). The reaction leads to the formation of corresponding α-substituted phosphonates in high yields. The reaction leading to the formation of bisphosphonates represents the highest interest. It was found that the nucleo philic attack of triethyl phosphite on the electron-deficient carbon of the C = X group leads to the formation of beta ine, which reacts with pyridinium perchlorate to form alkoxyphosphonium perchlorate and pyridine. Quasiphosphonium salt is unstable and decomposes to form phosphonate, alkene, and perchloric acid, which reacts with pyridine to regenerate pyridinium perchlorate. The intermediate formed from the pyridinium halide decomposes to form alkyl halide. The general strategy of the proposed method for introducing phosphonate groups into a polyprenyl mole cule consisted in the sequential treatment of hydroxyl-containing a compound with the Swern reagent with the con version of the C—OH group into a carbonyl one. Subsequent phosphonylation of the carbonyl-containing interme diate with the reagent (EtO)3P/[PyH] + ClO 4– leads to the formation of hydroxyalkylbisphosphonate. The synthe sized prenyl bisphosphonates have a pronounced biological activity. These include, for example, enolpyruvylshikimate-3- phosphate synthase (EPSP), farnesyl protein transferase (FPTase), as well as HIV protease, which are of interest as potential biologically active substances.

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Fang, Hua, Mei-Juan Fang, Xiao-Xia Liu, Jing-Jing Lin e Yu-Fen Zhao. "Dimethyl [phenyl(pyridine-4-carboxamido)methyl]phosphonate". Acta Crystallographica Section E Structure Reports Online 61, n. 2 (22 gennaio 2005): o408—o409. http://dx.doi.org/10.1107/s1600536805001492.

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Zare, Davood, Alessandro Prescimone, Edwin C. Constable e Catherine E. Housecroft. "Where Are the tpy Embraces in [Zn{4′-(EtO)2OPC6H4tpy}2][CF3SO3]2?" Crystals 8, n. 12 (10 dicembre 2018): 461. http://dx.doi.org/10.3390/cryst8120461.

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In this paper, the bromo- and phosphonate-ester-functionalized complexes [Zn(1)2][CF3SO3]2 and [Zn(2)2][CF3SO3]2 (1 = 4′-(4-bromophenyl)-2,2′:6′,2″-terpyridine, 2 = diethyl (4-([2,2′:6′,2″-terpyridin]-4′-yl)phenyl)phosphonate) are reported. The complexes have been characterized by electrospray mass spectrometry, IR and absorption spectroscopies, and multinuclear NMR spectroscopy. The single-crystal structures of [Zn(1)2][CF3SO3]2.MeCN.1/2Et2O and [Zn(2)2][CF3SO3]2 have been determined and they confirm {Zn(tpy)2}2+ cores (tpy = 2,2′:6′,2″-terpyridine). Ongoing from X = Br to P(O)(OEt)2, the {Zn(4′-XC6H4tpy)2}2+ unit exhibits significant “bowing” of the backbone, which is associated with changes in packing interactions. The [Zn(1)2]2+ cations engage in head-to-tail 4′-Phtpy...4′-Phtpy embraces with efficient pyridine...phenylene π-stacking interactions. The [Zn(2)2]2+ cations pack with one of the two ligands involved in pyridine...pyridine π-stacking; steric hindrance between one C6H4PO(OEt)2 group and an adjacent pair of π-stacked pyridine rings results in distortion of backbone of the ligand. This report is the first crystallographic determination of a salt of a homoleptic [M{4′-(RO)2OPC6H4tpy}2]n+ cation.

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Bakhmutov, Vladimir I., Douglas W. Elliott, Gregory P. Wylie, Abraham Clearfield, Aida Contreras-Ramirez e Hong-Cai Zhou. "Pyridine-d5 as a 2H NMR probe for investigation of macrostructure and pore shapes in a layered Sn(iv) phosphonate–phosphate material". Chemical Communications 56, n. 25 (2020): 3653–56. http://dx.doi.org/10.1039/c9cc09254d.

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Abstract (sommario):

Isotropic and anisotropic motions and molecular states of pyridine-d₅, adsorbed on the surface within the pores of a layered Sn(iv) phosphonate–phosphate material (1) have been characterized thermodynamically and kinetically by solid-state NMR.

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Fard, Z. H., Y. Kalinovskyy, D. M. Spasyuk, B. A. Blight e G. K. H. Shimizu. "Alkaline-earth phosphonate MOFs with reversible hydration-dependent fluorescence". Chemical Communications 52, n. 87 (2016): 12865–68. http://dx.doi.org/10.1039/c6cc06490f.

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A new rigid tritopic phosphonic ligand, 2,4,6-tris(4-phosphonophenyl)pyridine (H6L), was synthesized and used to assemble isostructural barium (1) and strontium (2) phosphonate metal organic frameworks that exhibit fully reversible and selective water-dependent fluorescence red-shift at room temperature.

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Zangana, Karzan H., Eufemio Moreno Pineda e Richard E. P. Winpenny. "Tetrametallic lanthanide(iii) phosphonate cages: synthetic, structural and magnetic studies". Dalton Trans. 43, n. 45 (2014): 17101–7. http://dx.doi.org/10.1039/c4dt02630f.

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Lipinski, Radoslaw, Longin Chruscinski, Piotr Mlynarz, Bogdan Boduszek e Henryk Kozlowski. "Coordination abilities of amino-phosphonate derivatives of pyridine". Inorganica Chimica Acta 322, n. 1-2 (ottobre 2001): 157–61. http://dx.doi.org/10.1016/s0020-1693(01)00580-1.

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Frantz, Richard, Michel Granier, Jean-Olivier Durand e Gérard F. Lanneau. "Phosphonate derivatives of pyridine grafted onto oxide nanoparticles". Tetrahedron Letters 43, n. 50 (dicembre 2002): 9115–17. http://dx.doi.org/10.1016/s0040-4039(02)02240-2.

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Holý, Antonín, e Ivan Rosenberg. "Synthesis of isomeric and enantiomeric O-phosphonylmethyl derivatives of 9-(2,3-dihydroxypropyl)adenine". Collection of Czechoslovak Chemical Communications 52, n. 11 (1987): 2775–91. http://dx.doi.org/10.1135/cccc19872775.

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Abstract (sommario):

Reaction of 9-(S)-(2,3-dihydroxypropyl)adenine (I) with chloromethanephosphonyl chloride (VII) in pyridine or triethyl phosphate, or with chloromethyl(pyridinio)phosphonate (IX) in pyridine, afforded a mixture of 2'-(IV) and 3'-O-chloromethanephosphonate (V) which were separated on anion exchange resin or alkylsilica gel. Treatment of compounds IV and V with aqueous alkaline hydroxide, followed by deionization, gave 9-(S)-(2-hydroxy-3-phosphonylmethoxypropyl)adenine (VI) and 9-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (III) (HPMPA), respectively. The (R)- and (RS)-forms of III and VI were prepared analogously from the respective (R)-enantiomer and racemate of I. 9-(S)-(2,3-Dihydroxypropyl)-N6-benzoyladenine (XIV) was converted into 3'-O-(dimethoxytrityl) derivative XVII and further into 2',N6-dibenzoyl derivative XIX. Reaction of compound XVII with IX, followed by acid hydrolysis and alkaline cyclization, afforded pure isomer VI whereas pure III was prepared from XIX by reaction with VII in triethyl phosphate and subsequent alkaline cyclization.

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Wang, Cheng Jun, Shan Shan Gong e Qi Sun. "An H-Phosphonate Approach for the Preparation of Purine-Nucleoside Monophosphates". Advanced Materials Research 1023 (agosto 2014): 51–54. http://dx.doi.org/10.4028/www.scientific.net/amr.1023.51.

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Two purine-nucleoside monophosphates have been prepared from the corresponding nucleoside 5′-H-phosphonate precursors via sequential silylation, oxidation, and hydrolysis reactions in a one-pot manner. Compared to the reaction performed in the presence of pyridine, the hydrolysis of iodophosphate in the absence of pyridine generated nucleoside 5′-monophosphates as the major product. The experimental results indicated that the reaction between the formed nucleoside 5′-monophosphate with the residual iodophosphate intermediate was relatively slow, making the self-condensed dinucleoside diphosphate a minor product in this reaction.

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Più fonti

Tesi sul tema "Pyridine phosphonate"

Petitpoisson, Lucas. "Dérivés basés sur les bispidines pour la complexation de métaux et une application en médecine nucléaire". Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAF054.

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L'émergence de nouveaux radioisotopes comme le terbium (149Tb, 152Tb, 155Tb, 161Tb) et le scandium (43Sc, 44Sc, 47Sc) suscite un intérêt croissant pour les sondes théranostiques en imagerie TEP et radiothérapie. L’optimisation de la sélectivité des radioconjugués implique l’utilisation d’anticorps et de chélateurs bifonctionnels capables de complexer ces isotopes dans des conditions douces tout en assurant la stabilité in vivo. Cependant, concilier cinétique de complexation et inertie cinétique reste un défi. Ce travail vise à développer de nouveaux ligands dérivés des bispidines, reconnus pour leurs complexes stables. Trois ligands ont été synthétisés : picolinate (L1), pyridine phosphonate (L2) et hydroxamate (L4). Leurs complexes avec le Tb(III) et le Sc(III) ont été étudiés, notamment les propriétés structurales, thermodynamiques et optiques. Des essais de complexation du Sc(III) et de son isotope 44Sc ont aussi été réalisés, ainsi que des recherches sur d'autres ligands potentiels
The emergence of new radioisotopes such as terbium (149Tb, 152Tb, 155Tb, 161Tb) and scandium (43Sc, 44Sc, 47Sc) has sparked growing interest in theranostic probes for PET imaging and radiotherapy. Enhancing radioconjugate selectivity often involves antibody-based targeting, requiring bifunctional chelators capable of complexing these metallic isotopes under mild conditions while ensuring in vivo stability. However, optimizing complexation kinetics can compromise kinetic inertness. This work aims to synthesize new bispidine-derived ligands, known for forming highly stable complexes. Three ligands were developed: picolinate (L1), pyridine phosphonate (L2), and hydroxamate (L4), to study their complexes with Tb(III) and Sc(III). The structural, thermodynamic, kinetic, and optical properties of L1 and L2 complexes with Tb(III) were examined. Similar studies were conducted with L1 for Sc(III) and its isotope 44Sc. Ligand L4 synthesis attempts and complexation trials were also explored

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Sappei, Celia. "Développement de nouveaux agents de contraste pour l'IRM à base de β- et α-cyclodextrines régio-fonctionnalisées par des ligands pyridino-carboxylate et -phosphonate". Thesis, Normandie, 2018. http://www.theses.fr/2018NORMR030/document.

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L’Imagerie par Résonance Magnétique est une technique d’imagerie possédant une des plus hautes résolutions d’images, utilisée pour le diagnostic clinique et en recherche. Cependant cette technique souffre d’une faible sensibilité intrinsèque due au faible contraste naturel entre les différents tissus. Pour pallier à cette limitation, des agents de contraste, principalement des complexes de Gd(III), sont actuellement utilisés et continus d’être développés. Ce projet de thèse s’inscrit dans la volonté de concevoir de nouveaux agents de contrastes plus efficaces et plus stables en utilisant la β- et l’α-cyclodextrines (CD) comme plateforme capables d’intégrer trois ou quatre fonctions pyridine-carboxylates ou pyridine-phosphonates, connues pour leur pouvoir chélatant du Gd(III). La première partie des travaux concerne les aménagements fonctionnels des CDs afin de pouvoir les fonctionnaliser régiosélectivement avec des bras chélatants du Gd(III) de types pyridino-carboxylate et pyridino-phosphonate. La deuxième partie traite de la caractérisation physico-chimique des nouveaux systèmes complexes Gd-ligands synthétisés (Gd-Lα et Gd-Lβ). Les principales propriétés caractérisant les agents de contraste ont été mesurées. Ainsi, de très bonne relaxivités ont été obtenue (25 mM-1s-1 < r1 < 40 mM-1s-1). Cependant, les stabilités des complexes se sont avérées faibles (4,24 < log KGdL < 5,58). En perspectives, il est nécessaire d’obtenir un juste équilibre entre une forte relaxivité et une stabilité élevée pour assurer la non-libération du Gd(III) toxique
Magnetic Resonance Imaging is one of the most important and non-invasive tools for clinical diagnostics and biomedical researches. Nevertheless, this modality suffers from intrinsic low sensitivity. To overcome this limitation, contrast agents, mostly based on polyaminocarboxylate complexes of gadolinium are used. The aim of this project was to design new Gd(III)-based contrast agents using β- and α-cyclodextrins (CD), known to generate high relaxivity, functionalized with pyridine-carboxylate and pyridine-phosphonate ligands, known for their good affinity with the lanthanide cations. Here we first investigated the regio-functionalization of the β-CD on the primary face to access to scaffold called Lβ with four pyridine-carboxylate ligands. To develop an efficient and reproducible synthesis, HPLC analysis was implemented. Then, using these conditions, carboxylate- and phosphonate-ester, precursors to access α-CD ligands Lα and Lα’, were synthesized. The carboxylate-ester deprotection step successfully afforded the ligand noted Lα contrary to the deprotection of phosphonate ester which still have to be explored. Characterizations of these complicated Gd-ligands systems (Gd-Lα et Gd-Lβ) were reported. Their stability and relaxivity were measured and very good relaxivities were obtained (25 mM-1s-1 < r1 < 40 mM-1s-1). These new structures open the way to an improvement in term of stability

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Škoda, Jakub. "2D struktury na bázi fosfonátů kovů; vztahy mezi uspořádáním a vlastnostmi studované metodami molekulárních simulací". Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-406121.

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This work deals with the structural analysis of layered zirconium sulfophenylphosphonates and their intercalates with the use of the classical molecular simulation methods. The inner composition of both fully and partially sulfonated layers was determined in agreement with available experimental data, especially chemical analysis, thermogravimetric measurements and X-ray diffraction. The calculations revealed the positions of the water molecules in the planes of sulfo groups which strongly affect the resultant diffraction pattern. Within the zirconium sulfophenylphosphonate layered structure, the arrangements of intercalated species based on optically active dipyridylamine molecules and cations of sodium, copper and iron were solved with the respect to the agreement with experimental results and values of potential energy. In case of the dipyridylamine molecules and its derivatives, the resultant disordered partially row arrangements of the organic molecules in the interlayer were showed to influence the dipole moment of the intercalate. From this point of view, nitro-derivative has been picked out as the most suitable for potential applications. Regarding the intercalated cations, sodium cations take up the space of water molecules next to the sulfo groups while copper and iron cations are distributed in a...

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Atti di convegni sul tema "Pyridine phosphonate"

Felczak, Krzysztof, e Krzysztof W. Pankiewicz. "Rehab of NAD-dependent enzymes with NAD-based inhibitors; synthesis of methylenebis(phosphonate) analogues of pyridone-3-carboxamide adenine dinucleotides". In XVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112204.

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Rapporti di organizzazioni sul tema "Pyridine phosphonate"

Paine, R. T. Various aspects of the chemistry of new pyridine phosphonates that are of specific interest to separations chemistry issues at Los Alamos National Laboratory. Final report, November 1992--September 1994. Office of Scientific and Technical Information (OSTI), agosto 1998. http://dx.doi.org/10.2172/656546.

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