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Tesi sul tema "Pseudoephedrine"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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1

Berry, Caroline. "Effect of Pseudoephedrine on 800-Meter Run Times of NCAA Division I Women Athletes." DigitalCommons@USU, 2011. https://digitalcommons.usu.edu/etd/1122.

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Abstract (sommario):

Pseudoephedrine is an over-the-counter drug commonly used as a decongestant, but also thought to have ergogenic effects. The World Anti-Doping Agency (WADA) has prohibited large doses (> 150 μg∙ml-1) of pseudoephedrine, while the National College Athletic Association (NCAA) does not include it on the banned substance list. The purpose of this study was to examine the effect of body weight dosing of pseudoephedrine on 800-m run times of NCAA female runners. Fifteen NCAA female track runners volunteered to participate in the randomized, double blind, crossover design. In trials that were a week

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2

Jayaram, Saravana Kumar. "A comprehensive chemical examination of methylamphetamine produced from pseudoephedrine extracted from cold medication." Thesis, University of Strathclyde, 2012. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=18133.

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Abstract (sommario):

This research evaluates the ability of gas chromatography mass spectrometry (GCMS), isotope ratio mass spectrometry (IRMS) and inductively coupled plasma mass spectrometry (ICPMS) to characterize methylamphetamine hydrochloride synthesised from precursors extracted from proprietary cold medication using three different extraction solvents. Two clandestine routes were utilized in the synthetic phase of the research, (i) Moscow route and (ii) Hypophoshorous route (Hypo). Repetitive batches of samples were prepared and analysed by each analytical technique to provide a robust sample set for data

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3

Chen, Hou Myers Andrew G. Myers Andrew G. "Transformation of alkylated pseudoephedrine amides to highly enantiomerically enriched carboxylic acids and ketones /." Diss., Pasadena, Calif. : California Institute of Technology, 1997. http://resolver.caltech.edu/CaltechETD:etd-01082008-105201.

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4

Mellem, Kevin T. "On the Development of Pseudoephenamine and Its Applications in Asymmetric Synthesis." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11227.

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Abstract (sommario):

Pseudoephedrine is well established as a chiral auxiliary in the alkylation of amide enolates to form tertiary and quaternary carbon stereocenters. However, due to its facile transformation into the illegal narcotic methamphetamine, pseudoephedrine is either illegal or highly regulated in many countries, which limits its use in academic and industrial settings. To address this issue, pseudoephenamine has been developed as a replacement for pseudoephedrine in organic synthesis. This new auxiliary suffers no regulatory issues and exhibits several practical advantages over pseudoephedrine, includ

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5

Harvey, Ross. "A Case Study of Policy Transfer: Examining the National Rollout of Project STOP." Thesis, Griffith University, 2013. http://hdl.handle.net/10072/365809.

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This thesis conducts a multi-level policy transfer analysis of a governmental response to the problem of pseudoephedrine diversion. Pseudoephedrine is an active ingredient in over-the counter cold and flu medication available from pharmacists and also acts as a precursor chemical in the illicit production of Amphetamine-Type-Stimulants (ATS). ATS are synthetically produced psychotropic drugs that are subject to international and national controls on their production, supply and use. Throughout the late 1990s and mid 2000s there was a large increase in the rates of use and production of ATS in

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6

Leksawasdi, Noppol Biotechnology &amp Biomolecular Sciences (BABS) UNSW. "Kinetics and modelling of enzymatic process for R-phenylacetylcarbinol (PAC) production." Awarded by:University of New South Wales. Biotechnology and Biomolecular Sciences (BABS), 2004. http://handle.unsw.edu.au/1959.4/20846.

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Abstract (sommario):

R-phenylacetylcarbinol (PAC) is used as a precursor for production of ephedrine and pseudoephedrine, which are anti-asthmatics and nasal decongestants. PAC is produced from benzaldehyde and pyruvate mediated by pyruvate decarboxylase (PDC). A strain of Rhizopus javanicus was evaluated for its production of PDC. The morphology of R. javanicus was influenced by the degree of aeration/agitation. A relatively high specific PDC activity (328 U decarboxylase g-1 mycelium) was achieved when aeration/agitation were reduced significantly in the latter stages of cultivation. The stability of partially

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7

Gillotin, Catherine. "Comparaison de la cinétique d'action de l'association acrivastine-pseudoéphédrine versus cétirizine versus placebo." Paris 5, 1993. http://www.theses.fr/1993PA05P239.

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8

Eckard, Phyllis R. "The Investigation of Primary and Secondary Modifiers in the Extraction and Separation of Neutral and Ionic Pharmaceutical Compounds with Pure and Modified Carbon Dioxide." Diss., Virginia Tech, 1998. http://hdl.handle.net/10919/30500.

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Abstract (sommario):

A successful supercritical fluid extraction method includes removal of the analyte from the matrix into the bulk fluid as well as trapping or concentration of the analyte prior to analysis. In the first phase of this research, the trapping capacities of three solid-phase traps (glass beads, 50/50 (w/w) glass beads/octadecylsilica), 50/50 (w/w) Porapak Q®/glass beads) were determined as a function of trap composition for a mixture of components varying in polarity and volatility. The Porapak Q®/glass beads mixture was found to be the most successful solidphase investigated exhibiting the highes

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9

Delgado, Leila Schreiner. "DESENVOLVIMENTO E VALIDAÇÃO DE METODOLOGIA ANALÍTICA PARA AVALIAÇÃO DE EBASTINA E CLORIDRATO DE PSEUDOEFEDRINA EM CÁPSULAS." Universidade Federal de Santa Maria, 2011. http://repositorio.ufsm.br/handle/1/5920.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Ebastine is a second generation antihistaminic clinically used for the treatment of allergic rhinitis and chronic urticaria. Pseudoephedrine hydrochloride is a direct- and indirectacting sympathomimetic, commonly combined with other drugs for their decongestant effect. In Brazil, this drugs association is available in capsules. In the literature, as well as in the official compendium, there are no methods for simultaneous analysis of ebastine and pseudoephedrine hydrochloride in pharmaceutical formulations. In the present work, l

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10

Betteridge, Scott Sheng-yi. "Pseudoephedrine and its effect on performance : a thesis presented in partial fulfillment of the requirements for the degree of Master of Science in Sport and Exercise Science at Massey University, Palmerston North, New Zealand." Massey University, 2007. http://hdl.handle.net/10179/970.

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Abstract (sommario):

Pseudoephedrine is a mild stimulant which partially mimics the action of noradrenaline and adrenaline. Recently, pseudoephedrine has been removed from the World Anti Doping Agency (WADA) prohibited substances list. This occurred despite limited research in regards to its effects on sporting performance, and no studies on prolonged exercise performance (>2hrs). There is some evidence to suggest pseudoephedrine may have an ergogenic effect at dosages exceeding therapeutic levels, possibly by masking fatigue. This study investigated the possible ergogenic effects of pseudoephedrine on endurance c

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11

Mouatt, Joshua Roger. "The physiological effects of pseudoephedrine on endurance cycling : a thesis submitted in the partial fulfilment of the requirements for the degree of Master of Science in Sport and Exercise Science, Massey University (Palmerston North, New Zealand)." Massey University, 2008. http://hdl.handle.net/10179/1013.

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Abstract (sommario):

Background: Pseudoephedrine (PSE) is a mild central nervous system stimulant that when consumed at a high dosage has the potential to alter physiological and psychophysical responses. PSE is widely accessible as over-the-counter medication and despite limited research into PSE at high dosages or its effects on prolonged exercise (>2 hours) is no-longer on the World Anti-Doping Association’s banned substance list. Currently unrestricted in sport and with no real understanding of the abovementioned responses during endurance exercise there is a high potential for abuse in sport. A recent study p

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12

Sebben, Viviane Cristina. "Análise de efedrinas e anfetamina em urina empregando spe e spme por cg/em/em." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2007. http://hdl.handle.net/10183/12004.

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O Brasil ocupa posição de destaque no consumo mundial de anfetaminas, contrariamente à tendência mundial de retração. Devido aos efeitos colaterais e ao alto potencial de abuso, a produção e comercialização de anfetaminas vêm sendo controladas no mundo inteiro. Com a restrição de uso, houve um retorno a procura pelos equivalentes naturais, especialmente as efedrinas presentes em diversas especialidades farmacêuticas, utilizadas no tratamento de doenças respiratórias. São componentes de vários compostos emagrecedores, suplementos alimentares e dietéticos utilizados para perda de peso e ganho de

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13

Koníčková, Veronika. "Přechod léčiv s obsahem pseudoefedrinu do skupiny OTC s omezením." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-112656.

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Abstract (sommario):

Goals: Prepare a case study on the transition to the new OTC medicines groups with restrictions. To evaluate the positives and negatives, which brought the introduction of the group - with OTC restrictions. Pick up generally applicable principles and specify non-functional parts of the system. Method: For data processing method was applied theoretical research. Literature was searched in the database of the Czech National Library - Klementinum, WHO database, TRIBUNE and interfaces of News portals. The instrumental case study was processed for a detailed insight into the issues. The case study

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14

Kučerová, Kateřina. "Distribuce léčivých přípravků s obsahem pseudoefedrinu." Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-76527.

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The thesis is focused on the distribution of medicinal products containing the active ingredient pseudoephedrine. These medicines are misused because of its active substance to produce an addictive methamphetamine (meth). The aim is to monitor the development restrictions associated with those drugs in the past, concern and characterize the current status of this issue. In the thesis, the theoretical knowledge of economics and drug problems. The practical part deals with the historical development of restrictions and evaluation of the status quo.

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15

Yang, Bryant H. "Use of pseudoephedrine as a practical chiral auxiliary for asymmetric synthesis." Thesis, 1997. https://thesis.library.caltech.edu/8089/1/Yang-bh-1997.pdf.

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<p> The use of pseudoephedrine as a practical chiral auxiliary for asymmetric synthesis is describe. Both enantiomers of pseudoephedrine are inexpensive commodity chemicals and can be N-acylated in high yields to form tertiary amides. In the presence of lithium chloride, the enolates of the corresponding pseudoephedrine amides undergo highly diastereoselective a1kylations with a wide range of alkyl halides to afford α-substituted products in high yields. These products can then be transformed in a single operation into highly enantiomerically enriched carboxylic acids, alcohols, and aldehydes

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16

Chen, Hou. "Transformation of alkylated pseudoephedrine amides to highly enantiomerically enriched carboxylic acids and ketones." Thesis, 1997. https://thesis.library.caltech.edu/69/1/Chen_h_1997.pdf.

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Abstract (sommario):

NOTE: Text or symbols not renderable in plain ASCII are indicated by [...]. Abstract is included in .pdf document. The noncatalyzed aldol addition of [...]-methylsilacyclobutane-[...],[...]-ketene acetals to aldehydes and the transformation of alkylated pseudoephedrine amides to highly enantiomerically enriched carboxylic acids and ketones are described. In Chapter 1, constraining of the silicon atom of an [...]-silyl ketene-[...],[...]-acetal within a four-membered ring is shown to greatly accelerate the rate of its noncatalyzed aldol addition to aldehydes and ketones. This reaction is highl

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17

McKinney, Phillip. "Using solid phase microextraction and gas chromatography/mass spectrometry when analyzing fire debris for pseudoephedrine, a prescursor drug in clandestine methamphetamine production." Thesis, 2016. https://hdl.handle.net/2144/17009.

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Abstract (sommario):

The production of methamphetamine in clandestine laboratories presents a particular hazard due to the environmental hazards it poses. In addition to the dangers associated with using caustic and reactive solvents, these clandestine laboratories also have to potential to cause a fire or explosion. This danger has caused some states to redefine arson to include fires caused by the illicit manufacture of drugs. Arson investigation can be challenging due to the destructive nature of the crime. Much of the evidence that existed prior the fire can be consumed and evidence that does survive can

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18

Lin, Chin-Hong, and 林錦紅. "Qualitative and Quantitative Determination Street Drug of Amphetamine, Methamphetamine, Ephedrine, Pseudoephedrine, Methylenedioxymethamphetamine and Ketamine by Capillary Zone Electrophoresis." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/06998521327750495333.

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碩士<br>高雄醫學大學<br>藥學研究所碩士在職專班<br>92<br>In study, we tried to find a rapid, sensitive method to qualitative and quantitative of A, MA, EPH, PEPH, MDMA and K these six abuse drugs at the same time by using capillary zone electrophoresis The best result was achieved by used 500 mM Boric acid mix with 20 mM Borax（pH 6.88）then 40 mM Borax buffer（pH 7.23）and applied two steps voltage of 10 kV 13.5 mins and 8 kV 6.5 mins. And UV detection was at 214 nm absorbance. The analytical precision was characterized by relative standard deviation values （R. S. D）<10% for migration times intra-day and

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19

Sun, Chin Lan, and 孫嘉蘭. "Qualitative and Quantitative Determination of Amphetamine, Methamphetamine, Ephedrine, Pseudoephedrine, Morphine and Codeine by Capillary Zone Electrophoresis-Electrospray Ion-Trap Mass Spectrometry." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/23823394733202575195.

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碩士<br>高雄醫學大學<br>職業安全衛生研究所<br>89<br>Because of the global overcast economy, domestic high unemployment, low work achievement, recession of life standard and illiteracy of teenagers, more and more people attempt to stupefy themselves by using drugs. Drug abuse impacts our society on direct and indirect cost to the medical and custodial care system. Additionally occupational accident and public danger will be occurred when people are working under the influence of drugs. Therefore screen for drug abuse is very important. Amphetamine (A), methamphetamine (MA), ephedrine (EPH), pseudoeph

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20

Shanati, Tarek. "Enantiokomplementäre Dehydrogenasen aus Arthrobacter sp. TS-15 zur stereoselektiven Oxidation von Ephedrinen und Reduktion aromatischer Ketoverbindungen." 2019. https://tud.qucosa.de/id/qucosa%3A34830.

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Zur stereoselektiven Herstellung von α-Hydroxyketonen aus prochiralen Ketonen stellen die Alkoholdehydrogenasen eine ökologische als auch ökonomische Alternative zu den verfügbaren industriellen Syntheserouten dar. Zurzeit stoßen sowohl die Biokatalyse als auch die organische Katalyse bei der Herstellung von sterisch anspruchsvollen α-Hydroxyketonen an ihre Grenzen. Die Synthese von enantiomerenreinem (R)-Phenylacetylcarbinol [(R)-PAC] und S- Phenylacetylcarbinol [(S)-PAC] aus dem prochiralen α-Diketon Phenylpropan-1,2-dion (PPD) stellt eine anspruchsvolle Synthese sowohl für akademische als a

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21

Kostraby, Margaret Mary. "The yeast mediated synthesis of the l-ephedrine precursor, l-phenylacetylcarbinol, in an organic solvent." Thesis, 1999. https://vuir.vu.edu.au/15623/.

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Abstract (sommario):

l-Ephedrine and d-pseudoephedrine are important pharmaceutical products commonly found in anti-asthmatic formulations, nasal decongestant mixtures and sinus preparations. d-Pseudoephedrine is the active ingredient in "Sudafed". l-Ephedrine is currently synthesised in a three step process. The first step utilises fermenting yeast in water to catalyse the acyloin condensation of benzaldehyde and acetaldehyde to form the l-ephedrine precursor, l-phenylacetylcarbinol (l-PAC). The second step involves the reaction of l-PAC with methylamine to form the corresponding N-methyl imine; the final step em

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