Letteratura scientifica selezionata sul tema "Protein interactions (PPI)"
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Articoli di riviste sul tema "Protein interactions (PPI)"
CHUA, HON NIAN, KANG NING, WING-KIN SUNG, HON WAI LEONG e LIMSOON WONG. "USING INDIRECT PROTEIN–PROTEIN INTERACTIONS FOR PROTEIN COMPLEX PREDICTION". Journal of Bioinformatics and Computational Biology 06, n. 03 (giugno 2008): 435–66. http://dx.doi.org/10.1142/s0219720008003497.
Testo completoKusova, Aleksandra M., Aleksandr E. Sitnitsky, Vladimir N. Uversky e Yuriy F. Zuev. "Effect of Protein–Protein Interactions on Translational Diffusion of Spheroidal Proteins". International Journal of Molecular Sciences 23, n. 16 (17 agosto 2022): 9240. http://dx.doi.org/10.3390/ijms23169240.
Testo completoPoot Velez, Albros Hermes, Fernando Fontove e Gabriel Del Rio. "Protein–Protein Interactions Efficiently Modeled by Residue Cluster Classes". International Journal of Molecular Sciences 21, n. 13 (6 luglio 2020): 4787. http://dx.doi.org/10.3390/ijms21134787.
Testo completoVelasco-García, Roberto, e Rocío Vargas-Martínez. "The study of protein–protein interactions in bacteria". Canadian Journal of Microbiology 58, n. 11 (novembre 2012): 1241–57. http://dx.doi.org/10.1139/w2012-104.
Testo completoKaur, Rajpreet, Poonam Khullar e Anita Gupta. "Protein-Protein Interactions Followed by in-Situ Synthesis of Gold Nanoparticles". ECS Transactions 107, n. 1 (24 aprile 2022): 16375–90. http://dx.doi.org/10.1149/10701.16375ecst.
Testo completoYang, Lei, e Xianglong Tang. "Protein-Protein Interactions Prediction Based on Iterative Clique Extension with Gene Ontology Filtering". Scientific World Journal 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/523634.
Testo completoAbdullah, Syahid, Wisnu Ananta Kusuma e Sony Hartono Wijaya. "Sequence-based prediction of protein-protein interaction using autocorrelation features and machine learning". Jurnal Teknologi dan Sistem Komputer 10, n. 1 (4 gennaio 2022): 1–11. http://dx.doi.org/10.14710/jtsiskom.2021.13984.
Testo completoOrasch, Oliver, Noah Weber, Michael Müller, Amir Amanzadi, Chiara Gasbarri e Christopher Trummer. "Protein–Protein Interaction Prediction for Targeted Protein Degradation". International Journal of Molecular Sciences 23, n. 13 (24 giugno 2022): 7033. http://dx.doi.org/10.3390/ijms23137033.
Testo completoKlein, Mark. "Targeting Protein-Protein Interactions to Inhibit Cyclin-Dependent Kinases". Pharmaceuticals 16, n. 4 (31 marzo 2023): 519. http://dx.doi.org/10.3390/ph16040519.
Testo completoZhang, Jinxiong, Cheng Zhong, Hai Xiang Lin e Mian Wang. "Identifying Protein Complexes from Dynamic Temporal Interval Protein-Protein Interaction Networks". BioMed Research International 2019 (21 agosto 2019): 1–17. http://dx.doi.org/10.1155/2019/3726721.
Testo completoTesi sul tema "Protein interactions (PPI)"
Weimann, Mareike. "A proteome-wide screen utilizing second generation sequencing for the identification of lysine and arginine methyltransferase protein interactions". Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16581.
Testo completoProtein methylation on arginine and lysine residues is a largely unexplored posttranslational modification which regulates diverse cellular processes. The development of efficient proteome-wide approaches for detecting protein methylation is limited and technically challenging. We developed a novel workload reduced yeast-two hybrid (Y2H) approach to detect protein-protein interactions utilizing second generation sequencing. The novel Y2H-seq approach was systematically evaluated against our state of the art Y2H-matrix screening approach and used to screen 8 protein arginine methyltransferases, 17 protein lysine methyltransferases and 10 demethylases against a set of 14,268 proteins. Comparison of the two approaches revealed a higher sensitivity of the new Y2H-seq approach. The increased sampling rate of the Y2H-seq approach is advantageous when assaying transient interactions between substrates and methyltransferases. Overall 523 interactions between 22 bait proteins and 324 prey proteins were identified including 11 proteins known to be methylated. Network analysis revealed enrichment of transcription regulator activity, DNA- and RNA-binding function of proteins interacting with protein methyltransferases. The dataset represents the first proteome-wide interaction network of enzymes involved in methylation and provides a comprehensively annotated resource of potential new methylation substrates. An in vitro methylation assay coupled to mass spectrometry revealed amino acid methylation of candidate proteins. Seven of nine proteins tested were methylated including SPIN2B, DNAJA3, QKI, SAMD3, OFCC1, SYNCRIP and WDR42A indicating that the interaction network is likely to contain many putative methyltransferase substrate pairs. The presented protein-protein interaction network demonstrates that protein methylation is involved in diverse cellular processes and can inform hypothesis driven investigation into molecular mechanisms regulated through methylation.
Peri, C. "INVESTIGATING AND PREDICTING THE DETERMINANTS OF PROTEIN-PROTEIN INTERACTIONS THROUGH COMPUTATIONAL-STRUCTURAL BIOLOGY APPROACHES: IMPLICATIONS FOR STRUCTURAL VACCINOLOGY". Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/243392.
Testo completoWorseck, Josephine Maria. "Characterization of phosphorylation-dependent interactions involving neurofibromin 2 (NF2, merlin) isoforms and the Parkinson protein 7 (PARK7, DJ1)". Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16533.
Testo completoAlterations in phosphorylation-dependent signalling pathways, accumulation of aggregated proteins in the brain and neuronal apoptosis are common to neurodegeneration and implicate overlapping molecular mechanism. To gain insight into involved pathways, a modified yeast-two hybrid (Y2H) system was applied to screen 71 proteins associated with neurological disorders in a proteome-wide manner. For 21 of these proteins interactions were identified including 5 phosphorylation-dependent ones. In total, the network connected 79 proteins through 90 protein-protein interactions (PPIs). A fraction of these Y2H PPIs was tested in secondary interaction assays with a validation rate of 66 %. The described network-based approach successfully identified proteins associated with more than one disorder and cellular functions connected to specific disorders. In particular, the network revealed Ser/Thr kinase-dependent PPIs between the Parkinson protein 7 (PARK7, DJ1) and the E3 ligase components ASB3 and RNF31 (HOIP). The function of these proteins further substantiates the established connection between Parkinson’s disease (PD) and ubiquitination-mediated proteasome (dis)functions. Neurofibromin 2 (NF2, merlin) isoforms and PARK7 were identified as PI3K regulatory subunit p55-gamma (PIK3R3) interactors. These PPIs required Tyr kinase coexpression in the modified Y2H system and functional PIK3R3 pTyr-recognition modules (SH2 domains) in co-IP and Venus PCA experiments. This finding implicates the PI3K/AKT survival pathway in PD-associated neuronal apoptosis and Neurofibromatosis type 2-associated tumour formation. Investigation of PIK3R3, AOF2 (KDM1A, LSD1) and EMILIN1 PPIs on NF2 isoform level revealed preferential isoform 7 binding and cytoplasmic or membrane localisation of these PPIs for isoform 7 or 1, respectively. The generated modification-dependent and isoform-specific PPI network triggered many hypotheses on the molecular mechanisms implicated in neurological disorders.
Lima, Leandro de Araujo. "Uma abordagem integrativa usando dados de interação proteína-proteína e estudos genéticos para priorizar genes e funções biológicas em transtorno de déficit de atenção e hiperatividade". Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/95/95131/tde-24082015-160400/.
Testo completoAttention-Deficit/Hyperactivity Disorder (ADHD) is the most common neuro-developmental disorder in children, affecting 5.8% of children and adolescents in the world. Many studies have attempted to investigate the genetic susceptibility of ADHD without much success. The present study aimed to analyze rare and common variants contributing to the genetic architecture of ADHD. We generated exome data from 30 Brazilian trios where the children were diagnosed with sporadic ADHD. We analyzed both single-nucleotide variants (SNVs) and copy-number variants (CNVs) in these trios and across multiple datasets, including a Brazilian sample of 503 children/adolescent controls from the High Risk Cohort Study for the Development of Childhood Psychiatric Disorders, and also previously published results of four CNV studies of ADHD involving children/adolescent Caucasian samples. The results from the Brazilian trios showed 3 major patterns: cases with inherited variations and de novo SNVs or de novo CNVs and cases with only inherited variations. Although the sample size is small, we could see that various comorbidities are more frequent in cases with only inherited variants. After exploring the rare variant composition in our 30 cases we selected genes with variations (SNVs or located in CNV regions) in our trio analysis that are recurrent in the families analyzed or in public data sets. Moreover, using only genes expressed in brain (post-mortem samples from Brain Atlas and The Genotype-Tissue Expression project), we constructed an in silico protein-protein interaction (PPI) network, with physical interactions confirmed by at least two sources. Topological and functional analyses of genes in this network uncovered genes related to synapse, cell adhesion, glutamatergic and serotoninergic pathways, both confirming findings of previous studies and capturing new genes and genetic variants in these pathways.
Alleman, Cécile. "Accès synthétique au châssis [5-8-5] de la fusicoccine-A pour la synthèse d’analogues simplifiés en vue d'étudier les interactions protéine-protéine". Electronic Thesis or Diss., Université de Rennes (2023-....), 2023. http://www.theses.fr/2023URENS090.
Testo completoIn biological media, protein-protein interactions (PPI) are of huge importance, as they allow the regulation of many cellular events. PPI classically involve two partners: an adapter protein and its effector protein(s) regulated either in a positive or a negative manner. Inhibition of PPI has thus been considered as a solid therapeutic approach. On the other hand, stabilization of PPI remains scarcely investigated, but may lead to new promising approaches. This project focuses on the 14-3-3 family adapter protein which interacts with more than 200 protein partners. Among them, p53 protein is subjected to a lot of studies as this tumor suppressor protein regulates multiple biological processes (DNA repair, apoptosis). However, those major functions appear to be silenced in most cancer cases, thus allowing tumor cells proliferation. Some studies have shown that stabilization of the 14-3-3/p53 pair with the help of a molecular glue permitted to restore tumor suppressor activity of p53. Among the examined molecular glues, the fusicoccin-A (FC-A) natural product is shown to lodge in the valley formed by 14-3-3 and increases stabilization of the 14-3-3/p53 interaction. In this context, to enlarge the p53/14-3-3 molecular glue library, this project focuses on the access to simplified FC-A analogs through the synthesis of tricyclic scaffold. [6-8-5] analogs from an aromatic substrate are envisaged, as well as [5-8-5] analogs from a cyclopentane derivative, closer to the target structure. Various strategies have been explored in order to access these analogs
Gilker, Eva Adeline Gilker. "INTERACTIONS AND LOCALIZATION OF PROTEIN PHOSPHATASES, YWHA PROTEINS AND CELL CYCLE CONTROL PROTEINS IN MEIOSIS". Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1532699317257539.
Testo completoRavindranath, Velaga M. "Elucidating the role of mitoferrin (Mfrn), iron regulatory proteins (IRP1 and IRP2) and hephaestin (Heph) in iron metabolism by tagSNP and protein-protein interaction (PPI) analysis". Thesis, London Metropolitan University, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.639414.
Testo completoJohansson-Åkhe, Isak. "PePIP : a Pipeline for Peptide-Protein Interaction-site Prediction". Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-138411.
Testo completoJohansson, Joakim. "Modifying a Protein-Protein Interaction Identifier with a Topology and Sequence-Order Independent Structural Comparison Method". Thesis, Linköpings universitet, Bioinformatik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-147777.
Testo completoSelim, Khaled [Verfasser]. "Structural and Functional Characterization of PII and PII-like Proteins and their Network of Interactions / Khaled Selim". Tübingen : Universitätsbibliothek Tübingen, 2021. http://d-nb.info/1233678507/34.
Testo completoLibri sul tema "Protein interactions (PPI)"
Winter, Sherry Lynn. Genetic and functional characterization of the interaction of BRCA1 with the serine/threonine phosphatase, PP1, and the circadian clock proteins, Per1 and Per2. 2006.
Cerca il testo completoCapitoli di libri sul tema "Protein interactions (PPI)"
Fernholz, Mikayla M., Leonie M. Windeln, Monika Papayova e Ali Tavassoli. "Chapter 6. Genetically Encoded SICLOPPS Libraries for the Identification of PPI Inhibitors". In Inhibitors of Protein–Protein Interactions, 218–31. Cambridge: Royal Society of Chemistry, 2020. http://dx.doi.org/10.1039/9781839160677-00218.
Testo completoTuncbag, Nurcan, Ozlem Keskin, Ruth Nussinov e Attila Gursoy. "Prediction of Protein Interactions by Structural Matching: Prediction of PPI Networks and the Effects of Mutations on PPIs that Combines Sequence and Structural Information". In Protein Bioinformatics, 255–70. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6783-4_12.
Testo completoYang, Xuan, e Andrey A. Ivanov. "CHAPTER 4. Computational Structural Modeling to Discover PPI Modulators". In Protein–Protein Interaction Regulators, 87–108. Cambridge: Royal Society of Chemistry, 2020. http://dx.doi.org/10.1039/9781788016544-00087.
Testo completoDoyle, Sean P., Xiulei Mo, Kun Qian, Danielle N. Cicka, Qiankun Niu e Haian Fu. "CHAPTER 3. High Throughput Screening Methods for PPI Inhibitor Discovery". In Protein–Protein Interaction Regulators, 49–86. Cambridge: Royal Society of Chemistry, 2020. http://dx.doi.org/10.1039/9781788016544-00049.
Testo completoSHI, LEI, XIUJUAN LEI e AIDONG ZHANG. "Protein Functional Module Analysis With Protein-Protein Interaction (PPI) Networks". In Algorithmic and Artificial Intelligence Methods for Protein Bioinformatics, 393–411. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118567869.ch20.
Testo completoHolzinger, Andreas, Anna Saranti, Anne-Christin Hauschild, Jacqueline Beinecke, Dominik Heider, Richard Roettger, Heimo Mueller, Jan Baumbach e Bastian Pfeifer. "Human-in-the-Loop Integration with Domain-Knowledge Graphs for Explainable Federated Deep Learning". In Lecture Notes in Computer Science, 45–64. Cham: Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-40837-3_4.
Testo completoKapadia, Paritosh, Saudamini Khare, Piali Priyadarshini e Bhaskarjyoti Das. "Predicting Protein-Protein Interaction in Multi-layer Blood Cell PPI Networks". In Communications in Computer and Information Science, 240–51. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-15-0111-1_22.
Testo completoGadde, Sai Gopala Swamy, Kudipudi Pravallika e Kudipudi Srinivas. "Evolutionary, Protein–Protein Interaction (PPI), and Domain–Domain Analyses in Huntington’s Disease". In Lecture Notes in Electrical Engineering, 11–23. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-6690-5_2.
Testo completoAhuja, Khushi, Aditi Joshi, Navjyoti Chakraborty, Ram Singh Purty e Sayan Chatterjee. "Comparative Analysis of Computational Methods used in Protein-Protein Interaction (PPI) Studies". In Computational and Analytic Methods in Biological Sciences, 63–100. New York: River Publishers, 2023. http://dx.doi.org/10.1201/9781003393238-4.
Testo completoWang, Wei, e Jinwen Ma. "Density Based Merging Search of Functional Modules in Protein-Protein Interaction (PPI) Networks". In Lecture Notes in Computer Science, 634–41. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-14922-1_79.
Testo completoAtti di convegni sul tema "Protein interactions (PPI)"
Lv, Guofeng, Zhiqiang Hu, Yanguang Bi e Shaoting Zhang. "Learning Unknown from Correlations: Graph Neural Network for Inter-novel-protein Interaction Prediction". In Thirtieth International Joint Conference on Artificial Intelligence {IJCAI-21}. California: International Joint Conferences on Artificial Intelligence Organization, 2021. http://dx.doi.org/10.24963/ijcai.2021/506.
Testo completoGhosh, Supratim, Burcu Guldiken, Maxime Saffon e Michael Nickeson. "Improved emulsification behaviour of pea protein-polysaccharide complexes for beverage application". In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/oniy9265.
Testo completoKralj, Sebastjan, Milan Hodošček, Marko Jukić e Urban Bren. "A comprehensive in silico protocol for fast automated mutagenesis and binding affinity scoring of protein-ligand complexes". In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.674k.
Testo completoZhao, Ziyuan, Peisheng Qian, Xulei Yang, Zeng Zeng, Cuntai Guan, Wai Leong Tam e Xiaoli Li. "SemiGNN-PPI: Self-Ensembling Multi-Graph Neural Network for Efficient and Generalizable Protein–Protein Interaction Prediction". In Thirty-Second International Joint Conference on Artificial Intelligence {IJCAI-23}. California: International Joint Conferences on Artificial Intelligence Organization, 2023. http://dx.doi.org/10.24963/ijcai.2023/554.
Testo completoUmbrin, Hina, e Saba Latif. "A survey on Protein Protein Interactions (PPI) methods, databases, challenges and future directions". In 2018 International Conference on Computing, Mathematics and Engineering Technologies (iCoMET). IEEE, 2018. http://dx.doi.org/10.1109/icomet.2018.8346326.
Testo completoMa, Xiaoke, e Lin Gao. "Detecting protein complexes in PPI networks: The roles of interactions". In 2011 IEEE International Conference on Systems Biology (ISB). IEEE, 2011. http://dx.doi.org/10.1109/isb.2011.6033120.
Testo completoOviya, I. R., Shanmukha Sravya N e Kalpana Raja. "R2V-PPI: Enhancing Prediction of Protein-Protein Interactions Using Word2Vec Embeddings and Deep Neural Networks". In 2024 Fourth International Conference on Advances in Electrical, Computing, Communication and Sustainable Technologies (ICAECT). IEEE, 2024. http://dx.doi.org/10.1109/icaect60202.2024.10469595.
Testo completo"PREDICTION OF PROTEIN INTERACTIONS ON HIV-1–HUMAN PPI DATA USING A NOVEL CLOSURE-BASED INTEGRATED APPROACH". In International Conference on Bioinformatics Models, Methods and Algorithms. SciTePress - Science and and Technology Publications, 2012. http://dx.doi.org/10.5220/0003769001640173.
Testo completoDimitrakopoulos, Georgios Ν., Konstantinos Lazaros, Aristidis G. Vrahatis, Marios Krokidis, Konstantina Skolariki, Panagiotis Vlamos e Themis Exarchos. "A Machine Learning approach combining omics data for Alzheimer’s Disease analysis". In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.342d.
Testo completoSoude, Anne, Martine Barth, Stephanie Bocart, Frederic Thoreau, Philippe Masson, Isabelle Braccini, Christian Montalbetti, Pierre Broqua e Claudia Fromond. "Abstract 894: Discovery of YAP-TEAD protein-protein interaction (PPI) inhibitors for cancer therapy". In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-894.
Testo completoRapporti di organizzazioni sul tema "Protein interactions (PPI)"
Avni, Adi, e Gitta L. Coaker. Proteomic investigation of a tomato receptor like protein recognizing fungal pathogens. United States Department of Agriculture, gennaio 2015. http://dx.doi.org/10.32747/2015.7600030.bard.
Testo completoSessa, Guido, e Gregory Martin. role of FLS3 and BSK830 in pattern-triggered immunity in tomato. United States Department of Agriculture, gennaio 2016. http://dx.doi.org/10.32747/2016.7604270.bard.
Testo completoNelson, Nathan, e Charles F. Yocum. Structure, Function and Utilization of Plant Photosynthetic Reaction Centers. United States Department of Agriculture, settembre 2012. http://dx.doi.org/10.32747/2012.7699846.bard.
Testo completoDickman, Martin B., e Oded Yarden. Modulation of the Redox Climate and Phosphatase Signaling in a Necrotroph: an Axis for Inter- and Intra-cellular Communication that Regulates Development and Pathogenicity. United States Department of Agriculture, agosto 2011. http://dx.doi.org/10.32747/2011.7697112.bard.
Testo completoChristopher, David A., e Avihai Danon. Plant Adaptation to Light Stress: Genetic Regulatory Mechanisms. United States Department of Agriculture, maggio 2004. http://dx.doi.org/10.32747/2004.7586534.bard.
Testo completoMorrison, Mark, Joshuah Miron, Edward A. Bayer e Raphael Lamed. Molecular Analysis of Cellulosome Organization in Ruminococcus Albus and Fibrobacter Intestinalis for Optimization of Fiber Digestibility in Ruminants. United States Department of Agriculture, marzo 2004. http://dx.doi.org/10.32747/2004.7586475.bard.
Testo completoWolf, Shmuel, e William J. Lucas. Involvement of the TMV-MP in the Control of Carbon Metabolism and Partitioning in Transgenic Plants. United States Department of Agriculture, ottobre 1999. http://dx.doi.org/10.32747/1999.7570560.bard.
Testo completoYosef, Carlos M. Production of High Transverse Momentum $\pi^0$ Mesons in Interactions of 530 GeV/c Proton and $\pi^-$ Beams on Beryllium and Copper Targets. Office of Scientific and Technical Information (OSTI), gennaio 1990. http://dx.doi.org/10.2172/1426709.
Testo completoRaghothama, Kashchandra G., Avner Silber e Avraham Levy. Biotechnology approaches to enhance phosphorus acquisition of tomato plants. United States Department of Agriculture, gennaio 2006. http://dx.doi.org/10.32747/2006.7586546.bard.
Testo completoChoudhary, Brajesh Chandra. A Study of High Transverse Momentum Direct Photon Production in Interactions of 500 GeV/c $\pi^{-}$ and Proton Beams on a Beryllium Target. Office of Scientific and Technical Information (OSTI), gennaio 1991. http://dx.doi.org/10.2172/1372873.
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